MY134743A - Derivatives of hydroxyamino-succinic acid - Google Patents

Derivatives of hydroxyamino-succinic acid

Info

Publication number
MY134743A
MY134743A MYPI93001217A MYPI9301217A MY134743A MY 134743 A MY134743 A MY 134743A MY PI93001217 A MYPI93001217 A MY PI93001217A MY PI9301217 A MYPI9301217 A MY PI9301217A MY 134743 A MY134743 A MY 134743A
Authority
MY
Malaysia
Prior art keywords
alkyl
atom
amino acid
carbamoyl
oxo
Prior art date
Application number
MYPI93001217A
Inventor
Michael John Broadhurst
Paul Anthony Brown
William Henry Johnson
Geoffrey Lawton
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MY134743A publication Critical patent/MY134743A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/22—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic

Abstract

THE INVENTION PROVIDES HYDROXAMIC ACID DERIVATIVES OF THE FORMULA WHEREIN RL REPRESENTS 1-7C ALKYL; R2 REPRESENTS HYDROGEN, 1-6C ALKYL OR A GROUP OF THE FORMULA -(CH2)N-ARYL OR -(CH2)N-HET IN WHICH N STANDS FOR 1-4 AND HET REPRESENTS A 5- OR 6-MEMBERED N-HETEROCYCLIC RING WHICH (A) IS ATTACHED VIA THE N ATOM, (B) OPTIONALLY CONTAINS N, 0 AND/OR S AS ADDITIONAL HETERO ATOM(S) IN A POSITION OR POSITIONS OTHER THAN ADJACENT TO THE LINKING N ATOM, (C) IS SUBSTITUTED BY OXO ON ONE OR BOTH C ATOMS ADJACENT TO THE LINKING N ATOM AND (D) IS OPTIONALLY BENZ-FUSED OR OPTIONALLY SUBSTITUTED ON ONE OR MORE OTHER CARBON ATOMS BY 1-6C ALKYL OR OXO AND/OR ON ANY ADDITIONAL N ATOM(S) BY 1-6C ALKYL; R3 REPRESENTS THE CHARACTERIZING GROUP OF A NATURAL OR NON-NATURAL a-AMINO ACID IN WHICH ANY FUNCTIONAL GROUP PRESENT MAY BE PROTECTED, WITH THE PROVISO THAT R3 DOES NOT REPRESENT HYDROGEN; R4 REPRESENTS CARBOXYL, (L-6C ALKOXY)CARBONYL, CARBAMOYL OR (1-6C ALKYL)CARBAMOYL; R5 REPRESENTS THE CHARACTERIZING GROUP OF A NATURALLY OCCURRING A-AMINO ACID IN WHICH ANY FUNCTIONAL GROUP PRESENT MAY BE PROTECTED; AND R6 REPRESENTS HYDROGEN; OR R4, R5 AND R6 EACH INDIVIDUALLY REPRESENT HYDROGEN OR 1-6C ALKYL, AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, WHICH ARE MATRIX METALLOPROTEINASE INHIBITORS USEFUL FOR THE CONTROL OR PREVENTION OF DEGENERATIVE JOINT DISEASES SUCH AS RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS OR FOR THE TREATMENT OF INVASIVE TUMOURS, ATHEROSCLEROSIS OR MULTIPLE SCLEROSIS. THEY CAN BE MANUFACTURED ACCORDING TO GENERALLY KNOWN METHODS BY DEPROTECTING A CORRESPONDING NOVEL BENZYLOXYAMINO COMPOUND OR HYDROXAMIDATING A CORRESPONDING NOVEL AMINO ACID OR ACTIVATED DERIVATIVE THEREOF.
MYPI93001217A 1992-06-25 1993-06-23 Derivatives of hydroxyamino-succinic acid MY134743A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929213473A GB9213473D0 (en) 1992-06-25 1992-06-25 Hydroxamic acid derivatives
GB939307081A GB9307081D0 (en) 1992-06-25 1993-04-05 Hydroxamic acid derivatives

Publications (1)

Publication Number Publication Date
MY134743A true MY134743A (en) 2007-12-31

Family

ID=10717706

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI93001217A MY134743A (en) 1992-06-25 1993-06-23 Derivatives of hydroxyamino-succinic acid

Country Status (12)

Country Link
KR (1) KR100311556B1 (en)
BR (1) BR9302642A (en)
GB (2) GB9213473D0 (en)
HR (1) HRP930980A2 (en)
MX (1) MX9303672A (en)
MY (1) MY134743A (en)
PL (1) PL299465A1 (en)
SI (1) SI9300313A (en)
TW (1) TW279157B (en)
UY (1) UY23606A1 (en)
YU (1) YU40293A (en)
ZA (1) ZA934398B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601368D0 (en) * 1986-01-21 1986-02-26 Ici America Inc Hydroxamic acids
US5189178A (en) * 1990-11-21 1993-02-23 Galardy Richard E Matrix metalloprotease inhibitors

Also Published As

Publication number Publication date
UY23606A1 (en) 1993-12-15
PL299465A1 (en) 1994-03-07
KR100311556B1 (en) 2002-02-19
SI9300313A (en) 1993-12-31
ZA934398B (en) 1993-12-27
GB9213473D0 (en) 1992-08-12
TW279157B (en) 1996-06-21
GB9307081D0 (en) 1993-05-26
HRP930980A2 (en) 1997-02-28
KR940005556A (en) 1994-03-21
BR9302642A (en) 1994-01-11
YU40293A (en) 1997-07-31
MX9303672A (en) 1994-01-31

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