UY23606A1 - PROCEDURE FOR THE PREPARATION OF HYDROXAMIC ACID DERIVATIVES.- - Google Patents
PROCEDURE FOR THE PREPARATION OF HYDROXAMIC ACID DERIVATIVES.-Info
- Publication number
- UY23606A1 UY23606A1 UY23606A UY23606A UY23606A1 UY 23606 A1 UY23606 A1 UY 23606A1 UY 23606 A UY23606 A UY 23606A UY 23606 A UY23606 A UY 23606A UY 23606 A1 UY23606 A1 UY 23606A1
- Authority
- UY
- Uruguay
- Prior art keywords
- atom
- preparation
- bonding
- procedure
- het
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
- C07C239/08—Hydroxylamino compounds or their ethers or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
- C07C239/08—Hydroxylamino compounds or their ethers or esters
- C07C239/22—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparación de compuestos de fórmula general (I) (figura 1) en donde R2 representa, entre otras posibilidades, un grupo de la fórmula -(CH2)n-Het en donde n tiene un valor de 1-4 y Het representa un anillo N-heterocíclico pentagonal o hexagonal que (a) está unido vía el átomo de N, (b) contiene opcionalmente N, O y/o S como heteroátomo(s) adicional(es) en una posición o posiciones distintas de adyacente(s) al átomo de N de enlace, (c) está sustituido por oxo o uno o ámbos átomos de C adyacentes al átomo de N de enlace y (d) está opcionalmente benzo-fusionado u opcionalmente sustituido en uno o más de otros átomos de carbono por alquilo de 1-6C; y sus sales famraceuticamente aceptables. Como ejemplo no limitante: etilamida de [4-(N-hidroxiamino)-2(R o S)-heptilsuccinil]-L-leucina. El medicamento es útil para el control o prevención de enfermedades de las articulaciones degenerativas o en el tratamiento de tumores invasivos, ateroesclerosis o esclerosis múltiple.The present invention refers to a process for the preparation of compounds of general formula (I) (figure 1) in which R2 represents, among other possibilities, a group of the formula - (CH2) n-Het in which n has a value of 1-4 and Het represents a pentagonal or hexagonal N-heterocyclic ring which (a) is attached via the N atom, (b) optionally contains N, O and / or S as additional heteroatom (s) in a position (s) other than adjacent to the bonding N atom, (c) is substituted by oxo or one or both of the C atoms adjacent to the bonding N atom and (d) is optionally benzo-fused or optionally substituted at one or more other carbon atoms per 1-6C alkyl; and its pharmaceutically acceptable salts. As a non-limiting example: [4- (N-hydroxyamino) -2 (R or S) -heptylsuccinyl] -L-leucine ethylamide. The drug is useful for the control or prevention of degenerative joint diseases or in the treatment of invasive tumors, atherosclerosis or multiple sclerosis.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929213473A GB9213473D0 (en) | 1992-06-25 | 1992-06-25 | Hydroxamic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
UY23606A1 true UY23606A1 (en) | 1993-12-15 |
Family
ID=10717706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY23606A UY23606A1 (en) | 1992-06-25 | 1993-06-24 | PROCEDURE FOR THE PREPARATION OF HYDROXAMIC ACID DERIVATIVES.- |
Country Status (12)
Country | Link |
---|---|
KR (1) | KR100311556B1 (en) |
BR (1) | BR9302642A (en) |
GB (2) | GB9213473D0 (en) |
HR (1) | HRP930980A2 (en) |
MX (1) | MX9303672A (en) |
MY (1) | MY134743A (en) |
PL (1) | PL299465A1 (en) |
SI (1) | SI9300313A (en) |
TW (1) | TW279157B (en) |
UY (1) | UY23606A1 (en) |
YU (1) | YU40293A (en) |
ZA (1) | ZA934398B (en) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8601368D0 (en) * | 1986-01-21 | 1986-02-26 | Ici America Inc | Hydroxamic acids |
US5189178A (en) * | 1990-11-21 | 1993-02-23 | Galardy Richard E | Matrix metalloprotease inhibitors |
-
1992
- 1992-06-25 GB GB929213473A patent/GB9213473D0/en active Pending
-
1993
- 1993-04-05 GB GB939307081A patent/GB9307081D0/en active Pending
- 1993-06-02 TW TW082104397A patent/TW279157B/zh active
- 1993-06-09 YU YU40293A patent/YU40293A/en unknown
- 1993-06-10 SI SI9300313A patent/SI9300313A/en unknown
- 1993-06-16 HR HR9213473.3A patent/HRP930980A2/en not_active Application Discontinuation
- 1993-06-18 ZA ZA934398A patent/ZA934398B/en unknown
- 1993-06-18 MX MX9303672A patent/MX9303672A/en not_active IP Right Cessation
- 1993-06-23 MY MYPI93001217A patent/MY134743A/en unknown
- 1993-06-24 PL PL93299465A patent/PL299465A1/en unknown
- 1993-06-24 KR KR1019930011598A patent/KR100311556B1/en not_active IP Right Cessation
- 1993-06-24 UY UY23606A patent/UY23606A1/en unknown
- 1993-06-24 BR BR9302642A patent/BR9302642A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ZA934398B (en) | 1993-12-27 |
KR940005556A (en) | 1994-03-21 |
YU40293A (en) | 1997-07-31 |
TW279157B (en) | 1996-06-21 |
KR100311556B1 (en) | 2002-02-19 |
MX9303672A (en) | 1994-01-31 |
GB9213473D0 (en) | 1992-08-12 |
GB9307081D0 (en) | 1993-05-26 |
SI9300313A (en) | 1993-12-31 |
MY134743A (en) | 2007-12-31 |
HRP930980A2 (en) | 1997-02-28 |
PL299465A1 (en) | 1994-03-07 |
BR9302642A (en) | 1994-01-11 |
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