YU33972B - Process for preparing 3,17beta-dihydroxy-11 beta-ethoxy-17 delta-ethynyl-estra-1,3,5(10)-triene - Google Patents

Process for preparing 3,17beta-dihydroxy-11 beta-ethoxy-17 delta-ethynyl-estra-1,3,5(10)-triene

Info

Publication number
YU33972B
YU33972B YU545/68A YU54568A YU33972B YU 33972 B YU33972 B YU 33972B YU 545/68 A YU545/68 A YU 545/68A YU 54568 A YU54568 A YU 54568A YU 33972 B YU33972 B YU 33972B
Authority
YU
Yugoslavia
Prior art keywords
17beta
estra
triene
ethynyl
dihydroxy
Prior art date
Application number
YU545/68A
Other languages
English (en)
Other versions
YU54568A (en
Inventor
Daniel Bertin
Bertin Daniel
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of YU54568A publication Critical patent/YU54568A/xx
Publication of YU33972B publication Critical patent/YU33972B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
YU545/68A 1966-06-07 1968-03-08 Process for preparing 3,17beta-dihydroxy-11 beta-ethoxy-17 delta-ethynyl-estra-1,3,5(10)-triene YU33972B (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR64481A FR5519M (xx) 1966-06-07 1966-06-07
FR75528A FR1514122A (fr) 1966-06-07 1966-09-07 Dérivés stéroïdes substitués en position 11 à noyau a aromatique et procédé de préparation
FR86879A FR6021M (xx) 1966-06-07 1966-12-09
FR91611A FR6030M (xx) 1966-06-07 1967-01-18
FR96848A FR6182M (xx) 1966-06-07 1967-02-28
FR98154A FR1540942A (fr) 1966-06-07 1967-03-09 Dérivés stéroïdes substitués en positions 11 et 17 à noyau a aromatique et procédé de préparation

Publications (2)

Publication Number Publication Date
YU54568A YU54568A (en) 1978-02-28
YU33972B true YU33972B (en) 1978-09-08

Family

ID=27546052

Family Applications (6)

Application Number Title Priority Date Filing Date
YU1125/67A YU33880B (en) 1966-06-07 1967-06-03 Process for preparing estra-1,3,5-(10)-triens oxidized in positions 3 and 17
YU1758/67A YU33882B (en) 1966-06-07 1967-09-07 Process for preparing estradiol derivatives
YU2408/67A YU33725B (en) 1966-06-07 1967-12-08 Process for preparing 3,17 oxidized esters of1,3,5(10)-trienes
YU109/68A YU34050B (en) 1966-06-07 1968-01-17 Process for preparing 3817beta-dihydroxy-11beta-ethoxy-estra-1,2,3(10)-trienes
YU455/68A YU33883B (en) 1966-06-07 1968-02-27 Process for preparing 3,17-dihydro-11beta-methoxy-17delta-ethinyl-estra-1,3,5-(10)-trienes
YU545/68A YU33972B (en) 1966-06-07 1968-03-08 Process for preparing 3,17beta-dihydroxy-11 beta-ethoxy-17 delta-ethynyl-estra-1,3,5(10)-triene

Family Applications Before (5)

Application Number Title Priority Date Filing Date
YU1125/67A YU33880B (en) 1966-06-07 1967-06-03 Process for preparing estra-1,3,5-(10)-triens oxidized in positions 3 and 17
YU1758/67A YU33882B (en) 1966-06-07 1967-09-07 Process for preparing estradiol derivatives
YU2408/67A YU33725B (en) 1966-06-07 1967-12-08 Process for preparing 3,17 oxidized esters of1,3,5(10)-trienes
YU109/68A YU34050B (en) 1966-06-07 1968-01-17 Process for preparing 3817beta-dihydroxy-11beta-ethoxy-estra-1,2,3(10)-trienes
YU455/68A YU33883B (en) 1966-06-07 1968-02-27 Process for preparing 3,17-dihydro-11beta-methoxy-17delta-ethinyl-estra-1,3,5-(10)-trienes

Country Status (14)

Country Link
US (2) US3526648A (xx)
AT (3) AT290023B (xx)
BE (2) BE699394A (xx)
CH (3) CH474495A (xx)
DE (1) DE1618830C3 (xx)
DK (2) DK121857B (xx)
ES (5) ES341435A1 (xx)
FR (6) FR5519M (xx)
GB (2) GB1152226A (xx)
IL (2) IL28113A (xx)
NL (2) NL6707903A (xx)
SE (2) SE335980B (xx)
SU (2) SU483828A3 (xx)
YU (6) YU33880B (xx)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2140258B1 (xx) * 1971-06-07 1974-08-23 Roussel Uclaf
US3906096A (en) * 1971-11-23 1975-09-16 Roussel Uclaf Novel 11{62 -alkoxy steroids
FR2183555B1 (xx) * 1972-05-10 1975-06-20 Roussel Uclaf
NL7613248A (nl) * 1976-11-26 1978-05-30 Akzo Nv Werkwijze voor het bereiden van nieuwe steroid- esters.
FR2401173A1 (fr) * 1977-06-27 1979-03-23 Roussel Uclaf Nouveaux steroides, leur procede de preparation et leur application dans la synthese de steroides marques au tritium
US4568673A (en) * 1984-03-20 1986-02-04 Wayne State University Compositions inhibiting murine MXT ductal carcinoma
US4636496A (en) * 1984-03-20 1987-01-13 Wayne State University Compositions inhibiting murine MXT ductal carcinoma
US4668668A (en) * 1984-03-20 1987-05-26 Wayne State University Compositions inhibiting murine MXT ductal carcinoma
US4705783A (en) * 1985-06-25 1987-11-10 Sri International 9α, 11β-substituted and 11β-substituted estranes
WO2002022645A2 (en) * 2000-09-14 2002-03-21 Accelerated Pharmaceuticals, Inc. Method of making 7alpha-methyl-11beta-methoxy estradiol and related compounds with estrogenic activity
CA2856520C (en) 2011-11-23 2021-04-06 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
MX2016014281A (es) 2014-05-22 2017-02-22 Therapeuticsmd Inc Formulaciones y terapias de reemplazo de combinación de hormonas naturales.
CA3006267C (en) 2014-11-26 2023-08-29 The Regents Of The University Of California Estrogen receptor modulators
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

Also Published As

Publication number Publication date
ES348057A1 (es) 1969-03-01
FR5519M (xx) 1967-11-06
SU432714A3 (xx) 1974-06-15
YU33725B (en) 1978-02-28
DK121857B (da) 1971-12-13
NL6707906A (xx) 1968-03-08
IL28113A (en) 1973-08-29
FR1514122A (fr) 1968-02-23
ES344805A1 (es) 1968-11-01
DK119925B (da) 1971-03-15
SE335980B (xx) 1971-06-21
DE1793738A1 (de) 1973-01-11
AT279815B (de) 1970-03-25
YU33883B (en) 1978-06-30
YU45568A (en) 1977-12-31
FR6182M (xx) 1968-07-15
DE1618830A1 (de) 1972-04-13
AT290023B (de) 1971-05-10
FR1540942A (fr) 1968-10-04
YU112567A (en) 1977-12-31
YU34050B (en) 1978-10-31
CH490361A (fr) 1970-05-15
FR6021M (xx) 1968-05-13
DE1618830B2 (de) 1974-07-04
GB1151404A (en) 1969-05-07
NL6707903A (xx) 1967-12-08
YU240867A (en) 1977-08-31
YU33880B (en) 1978-06-30
YU175867A (en) 1977-12-31
BE699394A (xx) 1967-12-04
IL28112A (en) 1973-08-29
ES341435A1 (es) 1968-07-01
CH474495A (fr) 1969-06-30
ES350987A1 (es) 1969-05-16
DE1618829A1 (de) 1971-01-14
CH475965A (fr) 1969-07-31
FR6030M (xx) 1968-05-13
YU54568A (en) 1978-02-28
YU33882B (en) 1978-06-30
US3579545A (en) 1971-05-18
GB1152226A (en) 1969-05-14
DE1618830C3 (de) 1975-02-20
AT301037B (de) 1972-08-25
SU483828A3 (ru) 1975-09-05
DE1793738B2 (de) 1975-11-27
US3526648A (en) 1970-09-01
SE335979B (xx) 1971-06-21
BE699393A (xx) 1967-12-04
ES351368A1 (es) 1969-06-01
YU10968A (en) 1978-05-15

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