YU32197A - Postupak za sintezu analoga paratiroidnog hormona i peptida srodnog paratiroidnom hormonu - Google Patents

Postupak za sintezu analoga paratiroidnog hormona i peptida srodnog paratiroidnom hormonu

Info

Publication number
YU32197A
YU32197A YU32197A YU32197A YU32197A YU 32197 A YU32197 A YU 32197A YU 32197 A YU32197 A YU 32197A YU 32197 A YU32197 A YU 32197A YU 32197 A YU32197 A YU 32197A
Authority
YU
Yugoslavia
Prior art keywords
pthrp
pth
analogs
synthesis
parathyroid hormone
Prior art date
Application number
YU32197A
Other languages
English (en)
Inventor
Humberto Arzeno
Original Assignee
F. Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of YU32197A publication Critical patent/YU32197A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Dat je postupak kondenzacije fragmenata za sintezu analoga paratiroidnog hormona (PTH) i peptida srodnog paratiroldnom hormonu (PTHrP) u kojem aminokiselinski ostaci (22-31) formiraju sintetički amfipatički α-heliks.
YU32197A 1996-07-30 1997-07-25 Postupak za sintezu analoga paratiroidnog hormona i peptida srodnog paratiroidnom hormonu YU32197A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2332296P 1996-07-30 1996-07-30

Publications (1)

Publication Number Publication Date
YU32197A true YU32197A (sh) 1999-07-28

Family

ID=21814418

Family Applications (1)

Application Number Title Priority Date Filing Date
YU32197A YU32197A (sh) 1996-07-30 1997-07-25 Postupak za sintezu analoga paratiroidnog hormona i peptida srodnog paratiroidnom hormonu

Country Status (30)

Country Link
US (1) US6849710B1 (sh)
EP (1) EP0822200B1 (sh)
JP (1) JP4229992B2 (sh)
KR (1) KR100518982B1 (sh)
CN (1) CN1293096C (sh)
AR (2) AR008094A1 (sh)
AT (1) ATE277080T1 (sh)
AU (1) AU731160B2 (sh)
BR (1) BR9704138A (sh)
CA (1) CA2206008C (sh)
CO (1) CO4650046A1 (sh)
CZ (1) CZ239697A3 (sh)
DE (1) DE69730787T2 (sh)
DK (1) DK0822200T3 (sh)
ES (1) ES2227639T3 (sh)
HR (1) HRP970416A2 (sh)
HU (1) HUP9701277A3 (sh)
IL (1) IL121391A0 (sh)
MA (1) MA24353A1 (sh)
MX (1) MX9705719A (sh)
NO (1) NO973482L (sh)
NZ (1) NZ328411A (sh)
PE (1) PE91998A1 (sh)
PL (1) PL321391A1 (sh)
SG (1) SG67408A1 (sh)
TR (1) TR199700714A2 (sh)
TW (1) TW505654B (sh)
UY (1) UY24651A1 (sh)
YU (1) YU32197A (sh)
ZA (1) ZA976555B (sh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2472472A1 (en) * 2002-01-10 2003-07-24 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
US7378495B2 (en) * 2002-10-21 2008-05-27 Pevion Biotech, Ltd. PTH-rP related peptide cancer therapeutics
BRPI0618469A2 (pt) * 2005-11-10 2011-08-30 Univ Michigan Tech hormÈnio paratiróide de urso preto e métodos de uso de hormÈnio paratiróide de urso preto
WO2007082890A1 (en) * 2006-01-17 2007-07-26 N.V. Organon SELECTIVE ENZYMATIC HYDROLYSIS OF C-TERMINAL tert-BUTYL ESTERS OF PEPTIDES
US7803770B2 (en) 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
ES2637283T3 (es) 2006-10-03 2017-10-11 Radius Health, Inc. Una composición estable que comprende PTHrP y usos de la misma
CN102448482A (zh) 2009-03-27 2012-05-09 范安德尔研究所 甲状旁腺素肽和甲状旁腺素相关蛋白肽及使用方法
CA2782640A1 (en) 2009-12-07 2011-06-16 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
CN102731643A (zh) * 2012-06-26 2012-10-17 深圳翰宇药业股份有限公司 一种治疗骨质疏松多肽的制备方法
CN102993293B (zh) * 2012-12-05 2014-05-07 深圳翰宇药业股份有限公司 一种特立帕肽醋酸盐的纯化方法
CA2907454C (en) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
CN105102427B (zh) 2013-03-21 2018-09-07 赛诺菲-安万特德国有限公司 含有环状酰亚胺的肽产物的合成
CN104530198B (zh) * 2014-12-09 2017-09-15 兰州大学 一种片段缩合制备醋酸去氨加压素的方法
CN113288887A (zh) 2015-04-29 2021-08-24 雷迪厄斯制药公司 用于治疗癌症的方法
EP3565542B1 (en) 2017-01-05 2024-04-10 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
EP3765488A1 (en) * 2018-03-12 2021-01-20 Fresenius Kabi iPSUM S.r.l. Process for the manufacture of pthrp analogue
AU2019297421A1 (en) 2018-07-04 2021-01-28 Radius Pharmaceuticals, Inc. Polymorphic forms of RAD 1901-2HCL
CN111057139B (zh) * 2018-10-17 2023-12-22 南京华威医药科技集团有限公司 一种制备特立帕肽的新工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886132A (en) * 1972-12-21 1975-05-27 Us Health Human parathyroid hormone
FR2550204B1 (fr) * 1983-08-05 1987-11-13 Toyo Jozo Kk Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
AU667662B2 (en) * 1990-07-13 1996-04-04 Regents Of The University Of California, The Parathyroid hormone analogues modified at positions 3, 6 or 9
GB9020544D0 (en) * 1990-09-20 1990-10-31 Sandoz Ltd Improvements in or relating to organic compounds
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
CN1070500C (zh) * 1993-07-13 2001-09-05 森德克斯(美国)股份有限公司 甲状旁腺激素类似物和甲状旁腺激素相关肽：合成和治疗骨质疏松症的用途
CO4410206A1 (es) * 1994-07-28 1997-01-09 Sandoz Ag DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN

Also Published As

Publication number Publication date
TR199700714A2 (xx) 1998-02-21
HRP970416A2 (en) 1998-08-31
CN1174845A (zh) 1998-03-04
MX9705719A (es) 1998-02-28
CA2206008A1 (en) 1998-01-30
AR008094A1 (es) 1999-12-09
JPH1077295A (ja) 1998-03-24
NZ328411A (en) 1998-12-23
CN1293096C (zh) 2007-01-03
JP4229992B2 (ja) 2009-02-25
HUP9701277A3 (en) 2001-02-28
HU9701277D0 (en) 1997-09-29
DK0822200T3 (da) 2005-01-31
ZA976555B (en) 1998-01-30
EP0822200B1 (en) 2004-09-22
KR980009282A (ko) 1998-04-30
PE91998A1 (es) 1998-12-31
DE69730787T2 (de) 2005-10-13
BR9704138A (pt) 1998-12-29
SG67408A1 (en) 1999-09-21
PL321391A1 (en) 1998-02-02
AR016981A2 (es) 2001-08-01
DE69730787D1 (de) 2004-10-28
IL121391A0 (en) 1998-01-04
NO973482L (no) 1998-02-02
HUP9701277A2 (hu) 1998-11-30
AU3236297A (en) 1998-02-05
US6849710B1 (en) 2005-02-01
ATE277080T1 (de) 2004-10-15
EP0822200A1 (en) 1998-02-04
TW505654B (en) 2002-10-11
KR100518982B1 (ko) 2006-05-29
NO973482D0 (no) 1997-07-29
AU731160B2 (en) 2001-03-22
CO4650046A1 (es) 1998-09-03
MA24353A1 (fr) 1998-07-01
CZ239697A3 (cs) 1998-04-15
UY24651A1 (es) 2000-12-29
ES2227639T3 (es) 2005-04-01
CA2206008C (en) 2008-09-23

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