WO2025033342A1 - 電子線照射装置、及び電子線の照射方法 - Google Patents

電子線照射装置、及び電子線の照射方法 Download PDF

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Publication number
WO2025033342A1
WO2025033342A1 PCT/JP2024/027706 JP2024027706W WO2025033342A1 WO 2025033342 A1 WO2025033342 A1 WO 2025033342A1 JP 2024027706 W JP2024027706 W JP 2024027706W WO 2025033342 A1 WO2025033342 A1 WO 2025033342A1
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WO
WIPO (PCT)
Prior art keywords
electron beam
beam irradiation
elongated member
medical elongated
partition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/JP2024/027706
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English (en)
French (fr)
Japanese (ja)
Inventor
暁雄 有坂
岳 松橋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to CN202480047503.6A priority Critical patent/CN121532838A/zh
Priority to JP2025539474A priority patent/JPWO2025033342A1/ja
Publication of WO2025033342A1 publication Critical patent/WO2025033342A1/ja
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/08—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation
    • B29C35/0866—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using particle radiation
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21K—HANDLING OF PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
    • G21K5/00—Irradiation devices
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21K—HANDLING OF PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
    • G21K5/00—Irradiation devices
    • G21K5/04—Irradiation devices with beam-forming means
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21K—HANDLING OF PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
    • G21K5/00—Irradiation devices
    • G21K5/10—Irradiation devices with provision for relative movement of beam source and object to be irradiated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/08—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation
    • B29C35/0866—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using particle radiation
    • B29C2035/0877—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using particle radiation using electron radiation, e.g. beta-rays

Definitions

  • the present invention relates to an electron beam irradiation device and an electron beam irradiation method.
  • a coating liquid e.g., a coating liquid containing a hydrophilic polymer that forms a lubricating coating layer
  • a coating liquid may be applied to the surface of the elongated medical component to form a coating layer on the surface of the elongated medical component.
  • a coating liquid is applied to the long medical component, a coating layer (a coating layer made from the coating liquid or a coating layer made by drying the coating liquid) is formed on the surface of the long medical component, and then the coating layer is hardened.
  • a coating layer a coating layer made from the coating liquid or a coating layer made by drying the coating liquid
  • the coating layer is hardened.
  • a method using ultraviolet light is often used for reasons such as simplifying the energy irradiating device and reducing manufacturing costs.
  • Patent Document 1 discloses an ultraviolet curing system that irradiates ultraviolet light onto a medical elongated member coated with a coating layer.
  • the ultraviolet curing system of Patent Document 1 includes multiple ultraviolet light bulbs extending in the longitudinal direction and a housing that holds the multiple ultraviolet light bulbs.
  • multiple medical elongated components coated with a coating layer are arranged at equal intervals inside a housing, and ultraviolet light is irradiated onto each of the multiple medical elongated components from multiple ultraviolet light bulbs, so that the ultraviolet light is evenly irradiated onto each part of the multiple medical elongated components.
  • ultraviolet rays Compared to electron beams, ultraviolet rays have a large amount of energy that is absorbed by the irradiated object and converted into heat. Therefore, when using ultraviolet rays to harden the coating layer, the ultraviolet rays can be absorbed by the irradiated object, causing a heat generation effect. Therefore, depending on the type of material that constitutes the long medical component, the heat generated during ultraviolet irradiation can cause damage such as deformation to the material that constitutes the long medical component, which can lead to a decrease in product quality. Furthermore, when using ultraviolet rays to harden the coating layer, it generally takes several seconds to several minutes for the coating layer to harden, depending on the material that forms the coating layer. Therefore, when using ultraviolet rays to harden the coating layer, it is difficult to improve the production efficiency of long medical components.
  • the device for hardening the coating layer must incorporate a chamber capable of being filled with inert gas and a transport mechanism for moving the long medical component to the position where the electron beam is irradiated.
  • the distance between the electron beam irradiation source and the long medical component must be kept relatively constant and precise, compared to the case of using ultraviolet radiation, in order to prevent uneven hardening of the coating layer, due to the characteristics of the hardening reaction. Therefore, when electron beams are used to harden the coating layer, it is necessary to devise a way to maintain the positional relationship between the electron beam irradiation source and the long medical component so that the distance between them does not change during the hardening process.
  • the distance between the gripping position of the medical elongated member and the electron beam irradiation position becomes long.
  • the object to be hardened by the electron beam is a coating layer applied to the surface of the medical elongated member, it is difficult to grip the part of the medical elongated member where the coating layer is located, and it is difficult to grip both ends of the medical elongated member and fix the medical elongated member to the electron beam irradiation device.
  • the object to be hardened by the electron beam is a coating layer applied to the surface of the medical elongated member
  • the medical elongated member is moved to the position where the electron beam is irradiated (for example, when the medical elongated member is moved into a chamber filled with an inert gas)
  • the medical elongated member is likely to be inadvertently deformed or displaced, which may cause a change in the distance between the electron beam irradiation source and the medical elongated member. Therefore, there is a concern that uneven hardening may occur in the coating layer applied to the medical elongated member.
  • the present invention has been made in consideration of the above problems, and aims to provide an electron beam irradiation device and an electron beam irradiation method that can maintain a constant distance between the emission surface of the electron beam irradiation unit and the object to be irradiated when irradiating an electron beam onto a coating layer applied to the object to be irradiated, thereby preventing uneven curing of the coating layer applied to the object to be irradiated.
  • the present invention can be achieved by any one of the following means (1) to (8).
  • An electron beam irradiation device comprising: an electron beam irradiation unit having an exit surface for emitting electron beams; an inactivation gas supply unit having an injection port for injecting inactivation gas; a chamber unit accommodating the exit surface and the injection port; a partition unit located within the chamber unit and facing the exit surface; and a transport mechanism configured to be able to place a part of an irradiated object in a space located between the exit surface and the partition unit, the injection port being located on the exit surface side within the chamber unit and inclined from the exit surface side toward the partition unit side, and the inactivation gas supply unit being configured to inject inactivation gas through the injection port toward a position on the partition unit facing the exit surface when a part of the irradiated object is placed in the space located between the exit surface and the partition unit.
  • the chamber portion has a hole portion that allows a portion of the irradiated object transported by the transport mechanism to be introduced into the chamber, and the transport mechanism is configured to place a portion of the irradiated object in the space located between the exit surface and the partition portion through the hole portion of the chamber portion.
  • the transport mechanism includes a rail portion extending toward the chamber portion and a gripping portion movable along the rail portion and configured to fix a portion of the irradiated object, and the transport mechanism is configured to move the gripping portion along the rail portion while the irradiated object is suspended by the gripping portion in the direction of gravity.
  • the irradiated object is a medical elongated member having a long body extending in the longitudinal direction and a hub portion disposed at one end of the body portion, the body portion having a first region coated with a lubricating coating layer that is to be irradiated with electron beams, and a second region disposed closer to the one end side than the first region and not coated with the lubricating coating layer, and the transport mechanism is configured to position the first region in the space located between the emission surface and the partition by moving the gripping portion while only the hub portion is fixed by the gripping portion.
  • An electron beam irradiation device for irradiating an irradiated object with an electron beam, the electron beam irradiation device comprising an electron beam irradiation section having an exit surface for emitting electron beams, an inactivation gas supply section having an injection port for injecting inactivation gas, a partition section facing the exit surface, and a transport mechanism configured to be able to place a part of the irradiated object in the space located between the exit surface and the partition section, and an electron beam irradiation method in which, with a part of the irradiated object being placed in the space located between the exit surface and the partition section, the inactivation gas is injected from the injection port located on the exit surface side onto the irradiated object, and, with the irradiated object in contact with the partition section with the inactivation gas, the electron beam is irradiated onto the irradiated object from the exit surface.
  • the transport mechanism includes a rail section and a gripping section that is movable along the rail section and is configured to be able to fix a part of the irradiated object
  • the irradiated object is a long medical member that includes a long body section extending in the longitudinal direction and a hub section disposed at one end of the body section, and the body section has a first region that is coated with a lubricating coating layer and is to be irradiated with electron beams, and a second region that is disposed on the base end side of the first region and is not coated with the lubricating coating layer
  • the transport mechanism moves the gripping section while fixing only the hub section with the gripping section, and irradiates the first region with electron beams while spraying an inert gas toward the irradiated object in a state where the first region is disposed in the space located between the exit surface and the partition section.
  • the nozzle of the inactivation gas supply unit that supplies the inactivation gas is located on the side of the emission surface of the electron beam irradiation unit that emits the electron beam in the chamber unit, and is inclined from the emission surface side of the electron beam irradiation unit toward the partition unit side.
  • the inactivation gas supply unit injects the inactivation gas through the nozzle toward a position on the partition unit that faces the emission surface of the electron beam irradiation unit, with a part of the irradiated object being placed in the space in the chamber unit located between the emission surface of the electron beam irradiation unit and the partition unit.
  • the electron beam irradiation method of (7) above can place a part of the irradiated object in the space between the exit surface of the electron beam irradiation unit that emits the electron beam and the partition, and then inject inactivating gas from the nozzle of the inactivating gas supply unit located on the exit surface side of the electron beam irradiation unit onto the irradiated object, thereby bringing the irradiated object into contact with the partition.
  • the electron beam irradiation method can maintain a constant distance between the exit surface of the electron beam irradiation unit and the irradiated object by bringing the irradiated object into contact with the partition.
  • the electron beam irradiation method can prevent uneven curing of the coating layer applied to the irradiated object by emitting electron beams from the exit surface of the electron beam irradiation unit onto the irradiated object while keeping the distance between the exit surface of the electron beam irradiation unit and the irradiated object constant.
  • FIG. 1 is a plan view showing an electron beam irradiation device according to a first embodiment of the present invention.
  • 2 is a side view showing the electron beam irradiation apparatus according to the first embodiment of the present invention, as seen from the direction of the arrow 2A in FIG. 1.
  • 3A is a cross-sectional view showing a work guide provided in the electron beam irradiation apparatus according to the first embodiment, taken along line 3A-3A of FIG. 1.
  • 5A to 5C are diagrams for explaining the operation of a work guide provided in the electron beam irradiation apparatus according to the first embodiment.
  • FIG. 1 is a diagram for explaining an electron beam irradiation method using an electron beam irradiation apparatus according to a first embodiment, showing a state before an electron beam is emitted from an electron beam irradiation unit and a state before an inactivation gas is sprayed from an inactivation gas supply unit.
  • FIG. 1 is a diagram for explaining an electron beam irradiation method using an electron beam irradiation apparatus according to a first embodiment, showing a state in which an electron beam is emitted from an electron beam irradiation unit and a state in which an inactivation gas is sprayed from an inactivation gas supply unit.
  • FIG. 2 is a cross-sectional view illustrating the vicinity of a partition, illustrating an electron beam irradiation method using the electron beam irradiation device according to the first embodiment.
  • FIG. 2 is a cross-sectional view illustrating the vicinity of a partition, illustrating an electron beam irradiation method using the electron beam irradiation device according to the first embodiment.
  • FIG. 4 is an enlarged cross-sectional view of a recess of a partition for explaining an electron beam irradiation method using the electron beam irradiation device according to the first embodiment.
  • FIG. 4 is an enlarged cross-sectional view of a recess of a partition for explaining an electron beam irradiation method using the electron beam irradiation device according to the first embodiment.
  • FIG. 13 is a diagram for explaining an electron beam irradiation method according to a comparative example.
  • FIG. 13 is a diagram for explaining an electron beam irradiation method according to a comparative example.
  • FIG. 13 is a diagram for explaining an electron beam irradiation method according to a comparative example.
  • FIG. 11 is a cross-sectional view showing a partition part according to the first modified example.
  • FIG. 11 is a cross-sectional view showing a partition part according to a second modified example.
  • FIG. 11 is a plan view showing an electron beam irradiation apparatus according to a second embodiment of the present invention.
  • FIG. 17 is a side view showing an electron beam irradiation apparatus according to a second embodiment of the present invention, as seen from the direction of an arrow 17A in FIG. 16.
  • 13A to 13C are diagrams for explaining an electron beam irradiation method using an electron beam irradiation apparatus according to a second embodiment.
  • First Embodiment 1 and 2 are simplified views showing the overall configuration of the electron beam irradiation device 10 according to the present embodiment.
  • Figs. 1 and 2 are partial cross-sectional views showing the chamber section 130 in cross section so that the inside of the chamber section 130 can be seen.
  • Figs. 3 and 4 are views showing a work guide 160 provided in the electron beam irradiation device 10.
  • Figs. 5 to 10 are views for explaining an electron beam irradiation method using the electron beam irradiation device 10.
  • Figs. 11 to 13 are views for explaining problems that arise in comparative examples.
  • the electron beam irradiation device 10 has an electron beam irradiation section 110 having an exit surface 111 for emitting electron beams, an inactivating gas supply section 120 having an injection port 121 for injecting inactivating gas, a chamber section 130 accommodating the exit surface 111 and the injection port 121, a partition section 140 located within the chamber section 130 and facing the exit surface 111, and a transport mechanism 150 configured to be able to position a portion of the irradiated object 300 in the space 130a located between the exit surface 111 and the partition section 140.
  • the direction in which the transport mechanism 150 transports the irradiated object 300 toward the chamber section 130 is referred to as the "first transport direction d1," and the direction in which the transport mechanism 150 transports the irradiated object 300 toward the side away from the chamber section 130 is referred to as the "second transport direction d2.”
  • the longitudinal direction of the electron beam irradiation device 10 (the direction in which the rail section 151 described later extends) is indicated by arrows X1-X2
  • the width direction of the electron beam irradiation device 10 that is perpendicular to the longitudinal direction in a plan view is indicated by arrows Y1-Y2
  • the height direction of the electron beam irradiation device 10 that is perpendicular to each of the longitudinal direction and the width direction is indicated by arrows Z1-Z2.
  • each direction of the electron beam irradiation device 10 is also simply referred to as the "longitudinal direction,” the "width
  • the irradiated object 300 is exemplified by a medical elongated member 300A having a long main body 310 extending in the longitudinal direction.
  • the electron beam irradiation device 10 is configured to simultaneously irradiate electron beams onto 15 medical elongated members 300A arranged at a predetermined interval in the width direction.
  • each of the 15 medical elongated members 300A has the same configuration. Therefore, only one medical elongated member 300A will be described, and descriptions of the other medical elongated members will be omitted. Similarly, for the identical configurations constructed in the electron beam irradiation device 10 corresponding to the 15 medical elongated members 300A, only one of the configurations will be described, and descriptions of the other configurations will be omitted as appropriate.
  • the chamber 130 includes an internal space 130A in which the electron beam irradiation unit 110 and the inert gas supply unit 120 are housed.
  • the chamber section 130 has a hole 135 that allows a portion of the irradiated object 300 transported by the transport mechanism 150 to be introduced into the chamber section 130.
  • the holes 135 are provided in a part of the wall of the chamber 130 located on the second transport direction d2 side.
  • the chamber 130 has 15 holes 135 corresponding to the number of irradiated objects 300.
  • the hole 135 can be configured to have a shape corresponding to the cross-sectional shape of the medical elongated member 300A.
  • the medical elongated member 300A has a substantially circular cross-sectional shape (see Figures 9 and 10). Therefore, the hole 135 is configured to have a circular shape that allows the medical elongated member 300A to be inserted therethrough.
  • the shape of the hole 135 there are no particular limitations on the shape of the hole 135 as long as the irradiated object 300 can be inserted therethrough.
  • the chamber 130 may be provided with an opening/closing mechanism (shutter section) (not shown) for opening and closing the hole 135.
  • an opening/closing mechanism shutter section
  • the electron beam irradiation device 10 operates the opening/closing mechanism to close the hole 135.
  • the electron beam irradiation device 10 operates the opening/closing mechanism to open the hole 135.
  • the device body 20 is disposed at the lower part of the chamber section 130 in the height direction.
  • the device body 20 is provided with a control section for controlling the emission and stop of the electron beam from the emission surface 111 of the electron beam irradiation section 110, and the emission and stop of the inactivation gas from the nozzle 121 of the inactivation gas supply section 120, as well as a drive source (motor) required to drive the operation of each section of the device.
  • the electron beam emitted from the emission surface 111 of the electron beam irradiation section 110 is illustrated by arrow e
  • the inactivation gas injected from the nozzle 121 of the inactivation gas supply section 120 is illustrated by arrow a.
  • the chamber section 130 has a predetermined length along the longitudinal direction.
  • the longitudinal length of the chamber section 130 (the longitudinal length of the internal space 130A) is set arbitrarily according to the longitudinal length of the part of the irradiated object 300 to be irradiated with the electron beam.
  • the longitudinal length of the chamber section 130 can be configured to accommodate the entire longitudinal range of the first region 311.
  • Transfer mechanism 150 As shown in FIGS. 1 and 2, the transfer mechanism 150 is located outside the chamber section 130.
  • the transport mechanism 150 is configured to place a portion (first region 311) of the medical elongated member 300A in the space 130a located between the emission surface 111 and the partition 140 through the hole 135 of the chamber 130.
  • the "space 130a located between the exit surface 111 and the partition section 140" is formed by a part of the internal space 130A of the chamber section 130. Specifically, the area in the internal space 130A located between the exit surface 111 of the electron beam irradiation section 110 and the partition section 140 corresponds to the "space 130a.”
  • the transport mechanism 150 includes a rail portion 151 that extends toward the chamber portion 130, and a gripping portion 153 that is movable along the rail portion 151 and is configured to be able to fix a portion of the medical elongated member 300A.
  • the rail portion 151 extends in a substantially straight line along the longitudinal direction of the electron beam irradiation device 10.
  • the direction in which the rail portion 151 extends is substantially the same as the longitudinal direction of the medical elongated member 300A.
  • the gripping portion 153 is configured to fix the hub portion 320 disposed at one end of the medical elongated member 300A.
  • the "one end of the medical elongated member 300A" is the portion that corresponds to the base end of the medical elongated member 300A, and is the end that is gripped or operated by a medical professional such as a doctor with his or her fingers during a procedure using the medical elongated member 300A.
  • the gripping portion 153 can be configured to be connectable and detachable to the rail portion 151.
  • the operator in the preparation stage for starting irradiation of the electron beam to the medical elongated member 300A by the electron beam irradiation device 10, the operator can fix the medical elongated member 300A to the gripping portion 153 in a state in which the gripping portion 153 is separated from the rail portion 151.
  • the operator can connect the gripping portion 153 to the rail portion 151 in a state in which the medical elongated member 300A is fixed to the gripping portion 153.
  • the gripping portion 153 may have a configuration in which it cannot be connected or detached to the rail portion 151.
  • the gripping portion 153 can be connected to the rail portion 151 via the slide portion 154.
  • the rail portion 151 is configured to be able to move linearly along the slide portion 154.
  • the gripping portion 153 moves along the rail portion 151 in conjunction with the movement of the slide portion 154.
  • the gripping portion 153 can be configured to have a chuck portion that mechanically and removably fixes the hub portion 320 by, for example, fitting the hub portion 320 to the gripping portion 153.
  • a chuck portion that mechanically and removably fixes the hub portion 320 by, for example, fitting the hub portion 320 to the gripping portion 153.
  • the gripping portion 153 there are no particular limitations on the specific configuration of the gripping portion 153, so long as it is capable of fixing and releasing at least a portion of the medical elongated member 300A.
  • the location where the medical elongated member 300A is fixed to the gripping portion 153 may be a portion other than the hub portion 320.
  • the transport mechanism 150 has a rotational operation part 155 that can drive the rotational operation of the gripping part 153 when the medical elongated member 300A is fixed to the gripping part 153.
  • the rotating action unit 155 is configured integrally with the gripping portion 153.
  • the hub portion 320 rotates in conjunction with the operation of the rotating action unit 155 while maintaining its fixed state by the gripping portion 153.
  • the rotating action unit 155 can rotate the medical elongated member 300A around the central axis 310c of the main body portion 310 of the medical elongated member 300A (see Figures 9 and 10).
  • the electron beam irradiation device 10 has a work guide 160 arranged at a predetermined position on the rail portion 151.
  • Figure 3 is a cross-sectional view taken along the arrow 3A-3A shown in Figure 1.
  • the work guide 160 serves to guide the movement of the medical elongated member 300A outside the chamber portion 130.
  • the work guide 160 has a first guide portion 161 and a second guide portion 162 that are configured to be able to move toward and away from each other.
  • a support hole 163 is formed between the first guide portion 161 and the second guide portion 162, through which the medical elongated member 300A is inserted and supported.
  • the electron beam irradiation device 10 supports a portion of the medical elongated member 300A in the support hole 163, thereby allowing the medical elongated member 300A to move smoothly along each transport direction d1, d2.
  • the size of the support hole 163 formed between the first guide part 161 and the second guide part 162 can be adjusted by changing the distance between the first guide part 161 and the second guide part 162. For example, as shown in FIG. 4, the size of the support hole 163 can be reduced by reducing the distance between the first guide part 161 and the second guide part 162. Therefore, by adjusting the size of the support hole 163 according to the size and cross-sectional shape of the irradiated object 300 (medical elongated member 300A) to be transported by the transport mechanism 150, the work guide 160 can guide the movement of various types of irradiated object 300.
  • each guide part 161, 162 can be attached to the rail part 151 via a support part 165 in which a slide groove that slidably holds each guide part 161, 162 is formed.
  • the electron beam irradiation device 10 of this embodiment is configured to be able to irradiate electron beams to a maximum of 15 medical elongated members 300A simultaneously. For this reason, the electron beam irradiation device 10 is provided with 15 gripping parts 153, rotating parts 155, and work guides 160.
  • the transport mechanism 150 When transporting the medical elongated member 300A, the transport mechanism 150, with the hub portion 320 fixed to the gripping portion 153, hangs the medical elongated member 300A so that the other end (corresponding to the "tip" of the medical elongated member 300A) located opposite the one end where the hub portion 320 is located is positioned below in the direction of gravity (a state in which the main body 310 of the medical elongated member 300A is stretched in its natural state with no external force being applied).
  • the transport mechanism 150 can move the medical elongated member 300A linearly along the first transport direction d1 and the second transport direction d2 while maintaining the medical elongated member 300A in the above-mentioned hanging state.
  • the inactivation gas supply unit 120 has not yet sprayed the medical elongated member 300A from the inactivation gas supply unit 120 in the chamber unit 130.
  • the medical elongated member 300A is not in contact with the partition unit 140. Therefore, the transport mechanism 150 can move the medical elongated member 300A with a predetermined gap g between the partition unit 140 and the medical elongated member 300A before the inactivation gas supply unit 120 sprays the inactivation gas onto the medical elongated member 300A.
  • the electron beam irradiation unit 110 includes an emission surface 111 arranged to face in the direction in which the electron beam is emitted.
  • the electron beam irradiation unit 110 is disposed on the same side of the internal space 130A of the chamber unit 130 as the inactivation gas supply unit 120.
  • the electron beam irradiation unit 110 and the inactivation gas supply unit 120 are disposed on the side facing the partition unit 140 in the height direction (arrow Z1-Z2 direction) of the chamber unit 130.
  • the emission surface 111 is positioned so that the electron beam is emitted in a direction approximately perpendicular to the partition 140, which is positioned opposite the electron beam irradiation unit 110 in the internal space 130A of the chamber 130.
  • the energy of the electron beam emitted from the emission surface 111 of the electron beam irradiation unit 110 can be set arbitrarily depending on the material to be hardened by the electron beam.
  • the energy of the electron beam can be set to, for example, 10 keV to 500 keV.
  • the inert gas supply unit 120 has an injection port 121 and a nozzle body 123.
  • the injection port 121 is disposed at one end of the nozzle body 123.
  • the nozzle 121 of the inactivating gas supply unit 120 is located on the side of the emission surface 111 of the electron beam irradiation unit 110 within the chamber unit 130, and is inclined from the emission surface 111 toward the partition unit 140. Therefore, as shown in FIG. 6, the inactivating gas injected from the nozzle 121 is injected diagonally forward toward the partition unit 140 along the inclination direction of the nozzle 121.
  • the inactivating gas supply unit 120 injects inactivating gas from the nozzle 121 with a portion of the medical elongated member 300A (a portion of the first region 311) disposed in the space 130a located between the exit surface 111 of the electron beam irradiation unit 110 and the partition 140.
  • the inactivating gas injected from the nozzle 121 is injected toward a position on the partition 140 facing the exit surface 111 of the electron beam irradiation unit 110.
  • the inactivated gas sprayed from the nozzle 121 of the inactivated gas supply unit 120 toward the space 130a moves a portion of the medical elongated member 300A arranged in the space 130a toward the partition 140.
  • the inactivated gas supply unit 120 sprays the inactivated gas from the nozzle 121, and brings a portion of the medical elongated member 300A into contact with the partition 140 at a position opposite the exit surface 111 of the electron beam irradiation unit 110 across the space 130a.
  • the electron beam irradiation device 10 can press each longitudinal portion of the medical elongated member 300A, which is moved sequentially into the space 130a by the transport mechanism 150, against the partition 140 while gas continues to be sprayed from the nozzle 121 of the inactivation gas supply unit 120.
  • the electron beam irradiation device 10 can keep the distance (straight-line distance LA shown in FIG. 6) between the exit surface 111 of the electron beam irradiation unit 110 and a portion of the medical elongated member 300A constant by pressing a portion of the medical elongated member 300A against the partition 140 with the inactivation gas sprayed from the nozzle 121 of the inactivation gas supply unit 120.
  • the electron beam irradiation device 10 can emit electron beams from the emission surface 111 of the electron beam irradiation unit 110 while keeping the distance between the emission surface 111 of the electron beam irradiation unit 110 and a part of the medical elongated member 300A constant, and can move the medical elongated member 300A along the first transport direction d1 by the transport mechanism 150. Therefore, the electron beam irradiation device 10 can continuously emit electron beams to each part in the longitudinal direction of the medical elongated member 300A while keeping the distance between the emission surface 111 of the electron beam irradiation unit 110 and each part in the longitudinal direction of the medical elongated member 300A constant. As a result, the electron beam irradiation device 10 can prevent uneven curing from occurring in each part in the longitudinal direction of the first region 311 of the medical elongated member 300A.
  • the inert gas used in the electron beam irradiation device 10 may be, for example, helium gas, neon gas, argon gas, xenon gas, nitrogen gas, etc.
  • the injection pressure XMPa of the inactivated gas injected from the injection port 121 of the inactivated gas supply unit 120 can be set, for example, in the range of 0.01 MPa ⁇ XMPa ⁇ 1 MPa.
  • the injection angle ⁇ 1 (see FIG. 6) of the inactivation gas injected from one injection port 121 can be set, for example, in the range of 10° ⁇ 1 ⁇ 90° (preferably, 30° ⁇ 1 ⁇ 90°).
  • the distance from the nozzle 121 of the inactivated gas supply unit 120 to the bottom 144 of the partition unit 140 can be set, for example, in the range of 0 mm ⁇ L mm ⁇ 500 mm.
  • the electron beam irradiation device 10 may have multiple inactivation gas supply units. For example, when the electron beam irradiation device 10 presses a part of the medical elongated member 300A against the partition 140 by the inactivation gas injected from the nozzle 121 of the inactivation gas supply unit 120, the electron beam irradiation device 10 may press another part of the medical elongated member against the partition 140 by the inactivation gas injected from the nozzle of another inactivation gas supply unit, thereby further reducing the positional deviation of the medical elongated member.
  • the other inactivation gas supply units other than the inactivation gas supply unit 120 can be disposed in a position between the inactivation gas supply unit 120 and the electron beam irradiation unit 110 in FIG. 5, or on the opposite side of the inactivation gas supply unit 120 and the electron beam irradiation unit 110 on the exit surface 111 side of the electron beam irradiation unit 110.
  • the spray angle of the inert gas sprayed from the nozzle of the inert gas supply unit can be set, for example, in the range of 10° ⁇ 170°.
  • Partition portion 140 As shown in FIGS. 7 and 8 , the partition section 140 has a plurality of walls 141 and a plurality of recesses 143 defined between a pair of the walls 141 .
  • FIG. 7 shows a cross-sectional view of the partition 140 at a location where the inactivation gas is not sprayed, as indicated by the arrow 7A in FIG. 6, and
  • FIG. 8 shows a cross-sectional view of the partition 140 at a location where the inactivation gas is sprayed, as indicated by the arrow 8A in FIG. 6.
  • Each wall 141 has a shape that protrudes approximately vertically toward the side where the electron beam irradiation unit 110 and the inactivation gas supply unit 120 are arranged within the chamber 130.
  • the recess 143 has a cross-sectional shape that is recessed on the side away from the emission surface 111 of the electron beam irradiation unit 110 and the injection port 121 of the inactivation gas supply unit 120 (the side of the arrow Z1 in this embodiment).
  • the partition 140 has a bottom 144 with a substantially linear cross-sectional shape at a position furthest from the exit surface 111 and the injection port 121. As shown in Figures 6 and 8, when the inactivated gas is injected into the medical elongated member 300A, at least a portion of the first region 311 of the medical elongated member 300A comes into contact with the bottom 144.
  • the first region 311 of the main body 310 of the medical elongated member 300A is not pressed against the partition 140 by the inactivating gas. Therefore, the first region 311 of the main body 310 of the medical elongated member 300A is positioned with a gap g between it and the bottom 144.
  • the electron beam is emitted from the exit surface 111 of the electron beam irradiation unit 110 toward the space 130a with the first region 311 of the main body 310 of the medical elongated member 300A in contact with the partition 140 (the bottom 144 of the partition 140) (see FIG. 6).
  • the medical elongated member 300A includes an elongated main body portion 310 extending in the longitudinal direction, and a hub portion 320 disposed at one end of the main body portion 310.
  • the main body 310 of the medical elongated member 300A can be configured to have a first region 311 coated with a lubricating coating layer 311a that is to be irradiated with electron beams, and a second region 312 that is disposed on one end side (base end side) of the first region 311 and is not coated with the lubricating coating layer 311a.
  • the area of the medical elongated member 300A that is to be irradiated with the electron beam is the first area 311 to which the lubricating coating layer 311a is applied. Therefore, when performing the operation of irradiating the electron beam, the transport mechanism 150 moves the medical elongated member 300A along each of the transport directions d1 and d2 at least within the range in which the first area 311 is positioned in the space 130a in the chamber section 130.
  • the transport mechanism 150 is configured to position the first region 311 of the medical elongated member 300A in the space 130a within the chamber 130 by moving the gripping portion 153 while only the hub portion 320 of the medical elongated member 300A is fixed by the gripping portion 153. Therefore, while the lubricating coating layer 311a is being hardened by irradiation with the electron beam, in the medical elongated member 300A, it is only the hub portion 320 that is gripped by the transport mechanism 150 and thus directly subjected to a gripping force (external force).
  • the main body 310 of the medical long member 300A can be made of, for example, a resin tubular member having a lumen 315 (see Figures 9 and 10) therein.
  • the material constituting the main body 310 can be, for example, a polyamide resin, a polyolefin resin such as a polyethylene resin or a polypropylene resin, a modified polyolefin resin, a cyclic polyolefin resin, an epoxy resin, a urethane resin, a diallyl phthalate resin (allyl resin), a polycarbonate resin, a fluororesin, an amino resin (urea resin, melamine resin, benzoguanamine resin), a polyester resin, a styrene resin, an acrylic resin, a polyacetal resin, a vinyl acetate resin, a phenolic resin, a vinyl chloride resin, a silicone resin (silicon resin), a polyether
  • the main body 310 of the medical long member 300A may contain a linear metal material as a reinforcing member inside the resin material.
  • metal materials include nickel-titanium alloys, cobalt-chromium alloys, magnesium alloys, stainless steel, platinum, and tungsten.
  • the medical elongated member 300A is, for example, a catheter having a long body portion 310 and a hub portion 320.
  • the catheter may be an angiography catheter, a support catheter, a microcatheter, a balloon catheter, or the like.
  • the medical elongated member 300A may also be configured, for example, from a guidewire known in the medical field. When the medical elongated member 300A is configured from a guidewire, it is not necessary to attach a hub portion 320 to one end of the medical elongated member 300A.
  • examples of the constituent materials include superelastic alloys such as nickel-titanium alloys and copper-zinc alloys, and metal materials such as stainless steel.
  • the material constituting the lubricating coating layer 311a applied to the medical elongated member 300A may be any material that absorbs water and exhibits lubricity.
  • hydrophilic materials may be mentioned. Specific examples are shown below.
  • the term “(meth)acrylic” includes both acrylic and methacrylic.
  • the term “(meth)acrylic acid” includes both acrylic acid and methacrylic acid.
  • the term “(meth)acryloyl” includes both acryloyl and methacryloyl.
  • the term “(meth)acryloyl group” includes both acryloyl and methacryloyl groups.
  • Hydrophilic materials constituting the lubricating coating layer 311a include, for example, hydrophilic polymers such as polyvinylpyrrolidone, polyvinyl alcohol, polyethylene oxide-based polymeric substances, cellulose-based polymeric substances such as carboxymethylcellulose, acrylamide-based polymeric substances such as polyacrylamide and polydimethylacrylamide, hyaluronic acid, polyacrylic acid, maleic anhydride-methyl vinyl ether copolymer-based polymeric substances, water-soluble nylon (registered trademark), and derivatives thereof.
  • hydrophilic polymers such as polyvinylpyrrolidone, polyvinyl alcohol, polyethylene oxide-based polymeric substances, cellulose-based polymeric substances such as carboxymethylcellulose, acrylamide-based polymeric substances such as polyacrylamide and polydimethylacrylamide, hyaluronic acid, polyacrylic acid, maleic anhydride-methyl vinyl ether copolymer-based polymeric substances, water-soluble nylon (registered trademark), and derivatives thereof.
  • the hydrophilic material constituting the lubricating coating layer 311a may be a hydrophilic copolymer containing a monomer having a reactive functional group (hereinafter also referred to as a "reactive monomer”) and a hydrophilic monomer in order to firmly fix the hydrophilic polymer to the medical elongated member 300A.
  • reactive functional group refers to a functional group that can undergo a cross-linking reaction with other monomers or react (bond) with the surface of the medical elongated member 300A by electron beam irradiation or the like.
  • the reactive functional group is not particularly limited, but may be an epoxy group, an acid halide group, an aldehyde group, an isocyanate group, an acid anhydride group, a vinyl group, a (meth)acryloyl group, or other functional group. These reactive functional groups may be present alone or in combination in the reactive monomer.
  • the reactive monomer used in the present invention preferably has a reactive functional group and exhibits hydrophobicity in body fluids or aqueous solvents, at least more hydrophobicity than the hydrophilic monomer used in the production of the copolymer.
  • reactive monomers include monomers having an epoxy group in the molecule, such as glycidyl acrylate, glycidyl methacrylate (GMA), methyl glycidyl methacrylate, and allyl glycidyl ether; monomers having an acid halide group in the molecule, such as (meth)acrylic acid chloride, (meth)acrylic acid bromide, and (meth)acrylic acid iodide; monomers having an aldehyde group in the molecule, such as (meth)acrylic aldehyde, crotonaldehyde, acrolein, and methacrolein; (meth)acryloyloxymethyl isocyanate, (meth)acryl
  • the reactive monomers include monomers having an isocyanate group in the molecule, such as (meth)acryloyloxyethyl isocyanate, (meth)acryloyloxypropyl isocyanate, and (meth)acryloyl isocyanate; monomers having an acid anhydride group in the molecule, such as maleic anhydride, itaconic anhydride, and citraconic anhydride; and monomers having a vinyl group in the molecule, such as vinyl chloride.
  • monomers having an isocyanate group in the molecule such as (meth)acryloyloxyethyl isocyanate, (meth)acryloyloxypropyl isocyanate, and (meth)acryloyl isocyanate
  • monomers having an acid anhydride group in the molecule such as maleic anhydride, itaconic anhydride, and citraconic anhydride
  • monomers having a vinyl group in the molecule such as vinyl chloride.
  • monomers having an epoxy group in the molecule such as glycidyl acrylate, glycidyl methacrylate (GMA), methyl glycidyl methacrylate, and allyl glycidyl ether.
  • GMA glycidyl methacrylate
  • methyl glycidyl methacrylate methyl glycidyl methacrylate
  • allyl glycidyl ether e.glycidyl acrylate, glycidyl methacrylate (GMA), methyl glycidyl methacrylate, and allyl glycidyl ether.
  • the hydrophilic monomer is not particularly limited, but examples thereof include acrylic acid, methacrylic acid, N-methylacrylamide, N,N-dimethylacrylamide (DMAA), acrylamide, acryloylmorpholine, N,N-dimethylaminoethyl acrylate, vinylpyrrolidone, 2-methacryloyloxyethyl phosphorylcholine, 2-methacryloyloxyethyl-D-glycoside, 2-methacryloyloxyethyl-D-mannoside, vinyl methyl ether, 2-hydroxyethyl (meth)acrylate, 4-hydroxybutyl (meth)acrylate, 2-hydroxypropyl (meth)acrylate, 2-hydroxybutyl (meth)acrylate, 6-hydroxyhexyl (meth)acrylate, 1,4-cyclohexanedimethanol mono(meth)acrylate, 1-chloro-2-hydroxypropyl (meth)acrylate, diethylene glycol mono(meth)acrylate
  • N,N-dimethylacrylamide acrylamide
  • acrylic acid methacrylic acid
  • N,N-dimethylaminoethyl acrylate 2-hydroxyethyl acrylate
  • vinylpyrrolidone a hydrophilic monomer
  • the hydrophilic material constituting the lubricating coating layer 311a may be a material containing only hydrophilic monomers in order to easily and firmly fix the hydrophilic polymer to the medical elongated member 300A.
  • the hydrophilic monomer contains a (meth)acryloyl group that can crosslink with other hydrophilic monomers or react (bond) with the surface of the medical elongated member 300A by electron beam irradiation.
  • such a hydrophilic monomer is a hydrophilic monomer containing a (meth)acryloyl group among the hydrophilic monomers described above.
  • a material containing only hydrophilic monomers is a material containing a single hydrophilic monomer containing a (meth)acryloyl group among the hydrophilic monomers described above, or a combination of two or more of them.
  • the hub portion 320 can be made of a material harder than the main body portion 310.
  • materials that can be used to make the hub portion 320 include polyethylene, polypropylene, polyamide, polycarbonate, and polystyrene.
  • the electron beam irradiation method is an electron beam irradiation device 10 that irradiates an electron beam onto a medical long-length member 300A.
  • the electron beam irradiation device 10 includes an electron beam irradiation unit 110 having an exit surface 111 for emitting electron beams, an inactivation gas supply unit 120 having an injection port 121 for injecting inactivation gas, a partition section 140 facing the exit surface 111, and a space 130a located between the exit surface 111 and the partition section 140, and a space 130a between the exit surface 111 and the partition section 140. and a transport mechanism 150 configured to be able to place a portion of the medical elongated member 300A.
  • an inactivated gas is sprayed onto the medical elongated member 300A from the spray nozzle 121 located on the emission surface 111 side, and with the medical elongated member 300A in contact with the partition 140 by the inactivated gas, an electron beam is irradiated onto the medical elongated member 300A from the emission surface 111.
  • the operator fixes the medical elongated members 300A to the gripping portion 153.
  • 15 medical elongated members 300A are set in the width direction (horizontal arrangement direction) of the electron beam irradiation device 10.
  • the operator fixes only the hub portion 320 of the medical elongated member 300A to the gripping portion 153.
  • the operator fixes the medical elongated member 300A to the gripping portion 153 with the gripping portion 153 separated from the rail portion 151.
  • the hub portion 320 is made of a harder material than the main body portion 310. Therefore, by fixing only the hub portion 320 of the medical elongated member 300A to the gripping portion 153, the electron beam irradiation device 10 can prevent inadvertent deformation or crushing of other portions of the main body portion 310 other than the hub portion 320.
  • the operator sends an instruction to the electron beam irradiation device 10 to start the electron beam irradiation operation by the electron beam irradiation device 10.
  • the electron beam irradiation device 10 is equipped with a work start button, the operator can start the operation by pressing the work start button.
  • the operator can also send a command to start the operation to the electron beam irradiation device 10 by operating an information terminal device, an external controller, etc.
  • the electron beam irradiation device 10 sprays an inactivated gas (e.g., nitrogen gas) from the inactivated gas supply unit 120 and starts the inactivated gas purge.
  • an inactivated gas e.g., nitrogen gas
  • the electron beam irradiation device 10 sends nitrogen gas from the inactivated gas supply unit 120 into the chamber unit 130, and removes the gas in the chamber unit 130 by replacing the gas in the chamber unit 130 with the inactivated gas.
  • the electron beam irradiation device 10 may be equipped with an exhaust mechanism (such as a duct or exhaust pump) (not shown) for exhausting the gas in the chamber unit 130 to the outside of the chamber unit 130. Note that while the inactivated gas purge is being performed, the hole 135 is kept closed by an opening and closing mechanism (not shown).
  • the electron beam irradiation device 10 After the inside of the chamber section 130 reaches a predetermined oxygen concentration, the electron beam irradiation device 10 emits electron beams from the emission surface 111 of the electron beam irradiation section 110.
  • the electron beam irradiation device 10 opens the hole 135, which is in a closed state, by an opening/closing mechanism (not shown).
  • the electron beam irradiation device 10 operates the transport mechanism 150 to move the gripper 153, to which the hub portion 320 of the medical elongated member 300A is fixed, along the rail portion 151 in the first transport direction d1. At this time, the transport mechanism 150 moves the gripper 153 along the direction of gravity in which the medical elongated member 300A is suspended, thereby moving the medical elongated member 300A into the chamber portion 130. With only the hub portion 320 fixed by the gripper 153, the medical elongated member 300A is introduced into the chamber portion 130 from the other end side of the medical elongated member 300A through the hole portion 135.
  • the electron beam irradiation device 10 can move the medical elongated member 300A in the direction of gravity while it is suspended by the transport mechanism 150, and therefore can achieve the following effects.
  • the application of the lubricating coating layer 311a to the medical elongated member 300A is often performed by dipping coating, which is performed by moving the medical elongated member 300A in the same direction as the direction of gravity using the transport mechanism 150. Therefore, when considering a series of manufacturing processes in which dipping coating is performed on the medical elongated member 300A and then the process of hardening the lubricating coating layer 311a is performed, the work efficiency of the manufacturing process can be improved by moving the medical elongated member 300A in a suspended state in the direction of gravity while hardening the lubricating coating layer 311a.
  • the electron beam irradiation device 10 can prevent the medical elongated member 300A from accidentally coming into contact with each part of the electron beam irradiation device 10 by moving the medical elongated member 300A along the direction of gravity while suspended by the transport mechanism 150.
  • a gap g (see FIG. 7) can be formed between the partition 140 and the part of the medical elongated member 300A to which the inactivating gas is not sprayed, so that the medical elongated member 300A can be prevented from coming into contact with the partition 140 at an unintended part. This can prevent the lubricating coating layer 311a applied to the main body 310 of the medical elongated member 300A from peeling off or falling off.
  • the electron beam irradiation device 10 can maintain the outer shape of the medical elongated member 300A so that the entire longitudinal direction of the medical elongated member 300A is substantially linear due to its own weight by moving the medical elongated member 300A along the direction of gravity while suspended by the transport mechanism 150. Therefore, the electron beam irradiation device 10 can more appropriately maintain the distance between the medical elongated member 300A and the emission surface 111 of the electron beam irradiation unit 110 when irradiating the lubricating coating layer 311a applied to the medical elongated member 300A with electron beams.
  • the electron beam irradiation device 10 When the electron beam irradiation device 10 moves the medical elongated member 300A using the transport mechanism 150, the electron beam irradiation device 10 can support a portion of the medical elongated member 300A using the work guide 160 disposed between the chamber portion 130 and the gripping portion 153. Therefore, when the electron beam irradiation device 10 moves the medical elongated member 300A using the transport mechanism 150, the electron beam irradiation device 10 can smoothly move the medical elongated member 300A along a linear path along the rail portion 151.
  • the electron beam irradiation device 10 moves the medical elongated member 300A by the transport mechanism 150 so that it passes through the space 130a in the chamber section 130.
  • the electron beam irradiation device 10 sprays the inactivated gas from the nozzle 121 of the inactivated gas supply unit 120 in an oblique direction toward the partition section 140.
  • the inactivated gas supply unit 120 can spray the inactivated gas at a spray angle ⁇ 1 of 45° and a spray pressure of 0.05 MPa.
  • the nozzle 121 of the inactivated gas supply unit 120 is inclined obliquely toward the first transport direction d1. Therefore, the inactivated gas sprayed from the nozzle 121 flows toward the first transport direction d1 while being sprayed onto the medical elongated member 300A. Therefore, the inactivated gas supply unit 120 can bring the medical elongated member 300A into contact with the partition 140 over a predetermined range along the first transport direction d1 from near the exit surface 111 of the electron beam irradiation unit 110 by the inactivated gas sprayed from the nozzle 121. This allows the electron beam irradiation device 10 to effectively prevent the medical elongated member 300A from shaking or bending within the chamber 130.
  • the electron beam irradiation device 10 does not directly spray the inactivating gas onto the portion of the medical elongated member 300A that is not located in the space 130a in the chamber portion 130. Therefore, while the transport mechanism 150 is transporting the medical elongated member 300A, the electron beam irradiation device 10 forms a gap g between the portion of the medical elongated member 300A that is not located in the space 130a and the partition portion 140. This prevents the lubricating coating layer 311a applied to the first region 311 from peeling off or falling off due to the portion not located in the space 130a accidentally coming into contact with the partition portion 140 while the medical elongated member 300A is being moved by the transport mechanism 150.
  • the electron beam irradiation device 10 presses the first region 311 of the medical elongated member 300A against the partition 140 by injecting the inactivating gas from the nozzle 121 of the inactivating gas supply unit 120. By pressing the first region 311 of the medical elongated member 300A against the partition 140, the electron beam irradiation device 10 can maintain a constant distance between the emission surface 111 of the electron beam irradiation unit 110 and the first region 311 of the medical elongated member 300A at a position corresponding to the space 130a.
  • the electron beam irradiation device 10 can maintain each part of the medical elongated member 300A in continuous contact with the partition 140 as each part of the medical elongated member 300A passes through the space 130a by continuously injecting the inactivation gas from the inactivation gas supply unit 120's injection port 121.
  • the electron beam irradiation device 10 can irradiate each part of the medical elongated member 300A in the longitudinal direction with the partition 140 at an equal distance from the emission surface 111 to each part of the first region 311 of the medical elongated member 300A arranged sequentially in the space 130a, while maintaining a constant distance between the emission surface 111 of the electron beam irradiation unit 110 and the main body 310 of the medical elongated member 300A.
  • the partition 140 has a recess 143 in which the medical elongated member 300A is placed when the inactivated gas is sprayed from the inactivated gas supply unit 120 onto the first region 311 of the medical elongated member 300A.
  • the recess 143 is recessed toward the side away from the emission surface 111 and the injection port 121.
  • the first region 311 of the medical elongated member 300A onto which the inactivated gas is sprayed moves away from the injection port 121 and is accommodated within the recess 143. Therefore, the electron beam irradiation device 10 can prevent the first region 311 of the medical elongated member 300A from being significantly misaligned in the width direction (arrow Y1-Y2 direction).
  • the electron beam irradiation device 10 when the electron beam irradiation device 10 irradiates the first region 311 of the medical elongated member 300A with an electron beam, the electron beam irradiation device 10 can more reliably maintain a constant distance between the emission surface 111 of the electron beam irradiation unit 110 and the first region 311 of the medical elongated member 300A.
  • the partition unit 140 can also prevent inadvertent contact between adjacent medical elongated members 300A in the width direction (arrow Y1-Y2 direction) by the inactivated gas injected from the injection port 121 due to the recess 143.
  • the electron beam irradiation device 10 After the entire longitudinal range of the first region 311 of the medical elongated member 300A to be irradiated with the electron beam has passed through the space 130a, the electron beam irradiation device 10 operates the rotation operation unit 155 to rotate the medical elongated member 300A by 180° around the central axis 310c of the main body 310, as shown in Figures 9 and 10.
  • the electron beam irradiation device 10 stops the spray of the inactivated gas from the inactivated gas supply unit 120.
  • the electron beam irradiation device 10 stops the spray of the inactivated gas from the inactivated gas supply unit 120, thereby preventing the lubricating coating layer 311a from rubbing against the partition 140 as the medical elongated member 300A rotates, causing the lubricating coating layer 311a to fall off, etc.
  • the reference symbol 311b illustrates an example of a portion of the lubricating coating layer 311a that has been hardened by the electron beam irradiated to the first region 311 of the main body 310 when the medical elongated member 300A is moved in the first transport direction d1.
  • the electron beam irradiation device 10 After rotating the medical elongated member 300A by 180° as described above, the electron beam irradiation device 10 operates the transport mechanism 150 to move the medical elongated member 300A along the second transport direction d2. The electron beam irradiation device 10 passes the first region 311 of the medical elongated member 300A through the space 130a by moving the medical elongated member 300A along the second transport direction d2 using the transport mechanism 150.
  • the electron beam irradiation device 10 When passing the first region 311 of the medical elongated member 300A through the space 130a along the second transport direction d2, the electron beam irradiation device 10 performs the injection of the inactivation gas from the inactivation gas supply unit 120 and the irradiation of the electron beam from the electron beam irradiation unit 110, in the same manner as when moving the medical elongated member 300A along the first transport direction d1.
  • the electron beam irradiation device 10 rotates the medical elongated member 300A by 180°, and then moves the medical elongated member 300A along the second transport direction d2 to pass through the space 130a, thereby irradiating the electron beam to the other side of the medical elongated member 300A opposite to the side of the medical elongated member 300A irradiated with the electron beam when the medical elongated member 300A is moved along the first transport direction d1.
  • the electron beam irradiation device 10 can prevent the longitudinal length of the chamber section 130 from becoming large.
  • the electron beam irradiation device 10 moves the gripper 153 to a predetermined position (the initial position on one end side of the rail portion 151). The operator removes the gripper 153 to which the medical elongated member 300A is fixed from the rail portion 151.
  • one end (base end) of the medical elongated member 600 is suspended in the weight direction by the gripping portion, and while the medical elongated member 600 is moved along the first transport direction d1 and the second transport direction d2, an electron beam is irradiated from the electron beam irradiation unit 500 to the medical elongated member 600.
  • FIG. 12 and 13 show an example in which the transport directions d1 and d2 of the medical elongated member 600 are set to the horizontal direction (perpendicular to the direction of gravity).
  • the transport directions d1 and d2 are set to the horizontal direction, there is a concern that the medical elongated member 600 may "float" in a direction intersecting the transport directions d1 and d2 as shown in FIG. 12, or that the other end of the medical elongated member 600 may "warp" in a direction intersecting the transport directions d1 and d2 as shown in FIG. 13.
  • the medical elongated member 600 When the medical elongated member 600 floats or warps, it becomes difficult to maintain a constant distance between the emission surface 511 of the electron beam irradiation unit 500 and the medical elongated member 600, as in the case where the medical elongated member 600 vibrates. As a result, the lubricating coating layer of the medical elongated member 600 may harden unevenly in each portion of the longitudinal direction of the medical elongated member 600.
  • a core bar into the elongated medical member 600, imparting rigidity and linearity to the elongated medical member 600 before transporting it. Even if such a measure is adopted, it is considered difficult to impart sufficient rigidity and linearity to the elongated medical member 600 if the elongated medical member 600 has a relatively small diameter (e.g., an outer diameter of 0.3 mm to 5.0 mm). Furthermore, not only does it require an additional process of attaching (inserting) the core bar to the elongated medical member 600, but it also requires management of the core bar (control of bending and cleanliness), which leads to reduced productivity.
  • the other end of the medical elongated member 600 may be crushed or deformed due to the load applied by the grasping to the other end of the medical elongated member 600.
  • the other end of the medical elongated member 600 is crushed or deformed, an additional process of removing the crushed or deformed portion is required.
  • the other end (tip) of the medical elongated member 600 may be given a tip shape such as an R shape depending on the product specifications.
  • the measure of grasping both ends of the medical elongated member 600 cannot be applied to the medical elongated member 600 to which a tip shape has been added. Furthermore, when a mechanism for gripping both ends of the medical elongated member 600 is provided in the electron beam irradiation device, it becomes necessary to configure the chamber section to a size large enough to accommodate the entire medical elongated member 600, including both ends. This leads to an increase in the size of the device configuration and a significant decrease in the efficiency of gas replacement when replacing the inside of the chamber section with an inert gas.
  • an inactivated gas is locally sprayed onto the medical elongated member 300A disposed in the space 130a in the chamber 130, so that a part of the medical elongated member 300A is brought into contact with the partition 140, thereby maintaining a constant distance between the medical elongated member 300A and the emission surface 111 of the electron beam irradiation unit 110.
  • This makes it possible to prevent uneven hardening of the lubricating coating layer 311a caused by the "vibration,” “floating,” “warping,” and the like of the medical elongated member 300A described in each comparison.
  • the electron beam irradiation device according to this embodiment can be suitably used for long medical components with a length of 10 cm or more and/or an outer diameter of 5.0 mm or less.
  • the electron beam irradiation device 10 according to this embodiment can be particularly suitably used for long medical components (especially catheters and guidewires) with a length of 100 cm or more and an outer diameter of 5.0 mm or less.
  • the electron beam irradiation device 10 includes an electron beam irradiation section 110 having an exit surface 111 for emitting electron beams, an inactivation gas supply section 120 having an injection port 121 for injecting inactivation gas, a chamber section 130 that houses the exit surface 111 and the injection port 121, a partition section 140 that is located within the chamber section 130 and faces the exit surface 111, and a space 130a that is located between the exit surface 111 and the partition section 140, into which a portion of the medical elongated member 300A can be placed.
  • the ejection port 121 is located on the side of the exit surface 111 in the chamber section 130 and is inclined from the exit surface 111 toward the partition section 140.
  • the inactivated gas supply section 120 is configured to eject the inactivated gas through the ejection port 121 toward a position on the partition section 140 facing the exit surface 111 with a part of the medical elongated member 300A disposed in the space 130a between the exit surface 111 and the partition section 140.
  • the nozzle 121 of the inactivation gas supply unit 120 that supplies the inactivation gas is located on the side of the exit surface 111 of the electron beam irradiation unit 110 that emits electron beams in the chamber unit 130, and is inclined from the exit surface 111 of the electron beam irradiation unit 110 toward the partition unit 140.
  • the inactivation gas supply unit 120 injects the inactivation gas through the nozzle 121 toward a position on the partition unit 140 facing the exit surface 111 of the electron beam irradiation unit 110.
  • the part of the medical elongated member 300A onto which the inactivation gas is sprayed comes into contact with the partition unit 140.
  • the electron beam irradiation device 10 can maintain a constant distance between the exit surface 111 of the electron beam irradiation unit 110 and the medical elongated member 300A by contacting a part of the medical elongated member 300A with the partition 140 using an inactivated gas.
  • the electron beam irradiation device 10 can prevent uneven hardening of the lubricating coating layer 311a applied to the medical elongated member 300A by emitting electron beams from the exit surface 111 of the electron beam irradiation unit 110 to the medical elongated member 300A while maintaining a constant distance between the exit surface 111 of the electron beam irradiation unit 110 and the medical elongated member 300A.
  • the transport mechanism 150 is located outside the chamber section 130, and the chamber section 130 has a hole section 135 that allows a portion of the medical elongated member 300A transported by the transport mechanism 150 to be introduced into the chamber section 130, and the transport mechanism 150 is configured to place a portion of the medical elongated member 300A in the space 130a located between the emission surface 111 and the partition section 140 through the hole section 135 of the chamber section 130.
  • the transport mechanism 150 is located outside the chamber section 130, so there is no need to enlarge the chamber section 130 to accommodate the transport mechanism 150.
  • the electron beam irradiation device 10 can introduce the medical elongated member 300A transported by the transport mechanism 150 into the chamber section 130 through the hole 135 of the chamber section 130, so that a portion of the medical elongated member 300A can be smoothly positioned in the space 130a within the chamber section 130.
  • the transport mechanism 150 includes a rail portion 151 extending toward the chamber portion 130, and a gripping portion 153 that is movable along the rail portion 151 and configured to be able to fix a portion of the medical elongated member 300A, and the transport mechanism 150 is configured to move the gripping portion 153 along the rail portion 151 while the medical elongated member 300A is suspended in the direction of gravity by the gripping portion 153.
  • the electron beam irradiation device 10 configured as described above can prevent the medical elongated member 300A from accidentally coming into contact with each part of the electron beam irradiation device 10 by moving the medical elongated member 300A along the direction of gravity while suspended by the transport mechanism 150.
  • a gap g can be formed between the part of the medical elongated member 300A to which the inactivation gas is not sprayed and the partition 140, so that the medical elongated member 300A can be prevented from coming into contact with the partition 140 at an unintended location.
  • the electron beam irradiation device 10 can maintain the external shape of the medical elongated member 300A so that the entire longitudinal direction of the medical elongated member 300A is approximately linear due to its own weight by moving the medical elongated member 300A along the direction of gravity while suspended by the transport mechanism 150. Therefore, when irradiating the lubricating coating layer 311a applied to the medical elongated member 300A with an electron beam, the electron beam irradiation device 10 can more appropriately maintain the distance formed between the medical elongated member 300A and the emission surface 111 of the electron beam irradiation unit 110.
  • the irradiated object 300 is a medical elongated member 300A having a long body portion 310 extending in the longitudinal direction and a hub portion 320 arranged at one end of the body portion 310.
  • the body portion 310 has a first region 311 coated with a lubricating coating layer 311a that is the target of electron beam irradiation, and a second region 312 that is arranged closer to the one end side of the body portion 310 than the first region 311 and is not coated with the lubricating coating layer 311a.
  • the transport mechanism 150 is configured to move the gripping portion 153 while only the hub portion 320 is fixed by the gripping portion 153, thereby placing the first region 311 in the space 130a located between the emission surface 111 and the partition portion 140.
  • the electron beam irradiation device 10 configured as described above moves the medical elongated member 300A and irradiates the first region 311 of the main body 310 to which the lubricating coating layer 311a is applied with electron beams while only the hub portion 320 of the medical elongated member 300A is fixed to the gripping portion 153. Therefore, the electron beam irradiation device 10 can prevent the main body 310 of the medical elongated member 300A from being inadvertently deformed or crushed while each task using the device 10 is being performed.
  • the electron beam irradiation device 10 moves the medical elongated member 300A while only the hub portion 320 of the medical elongated member 300A is fixed to the gripping portion 153, the other end (tip) side of the medical elongated member 300A can be moved without being restrained by other members. Therefore, the electron beam irradiation device 10 can smoothly move the other end side of the medical elongated member 300A inside and outside the chamber portion 130.
  • the transport mechanism 150 has a rotation operation unit 155 that can drive the rotation operation of the gripper 153 when the gripper 153 is in a state in which the medical elongated member 300A is fixed.
  • the electron beam irradiation device 10 configured as described above can rotate the medical elongated member 300A by 180° based on the central axis 310c of the main body 310 by operating the rotation operation unit 155 after the entire longitudinal range of the first region 311 of the medical elongated member 300A to be irradiated with the electron beam has passed through the space 130a once.
  • the electron beam irradiation device 10 can irradiate the medical elongated member 300A with the electron beam by moving the medical elongated member 300A again to pass through the space 130a while irradiating the medical elongated member 300A with the electron beam, thereby irradiating both the surface on one side of the main body 310 in the circumferential direction and the surface on the opposite side.
  • the electron beam irradiation device 10 can irradiate the electron beam evenly to the entire circumferential range of the medical elongated member 300A.
  • the partition 140 has a recess 143 recessed on the side away from the emission surface 111 and the injection port 121.
  • the electron beam irradiation device 10 configured as described above can be positioned so that the first region 311 of the main body 310 is contained within the recess 143 when inactivating gas is sprayed onto the medical elongated member 300A placed in the space 130a. Therefore, the electron beam irradiation device 10 can prevent the first region 311 of the medical elongated member 300A from being significantly misaligned in the width direction (arrow Y1-Y2 direction).
  • the electron beam irradiation device 10 can more reliably maintain a constant distance between the exit surface 111 of the electron beam irradiation unit 110 and the first region 311 of the medical elongated member 300A when irradiating the first region 311 of the medical elongated member 300A with an electron beam.
  • the partition 140 can also prevent inadvertent contact between adjacent medical elongated members 300A in the width direction (arrow Y1-Y2 direction) by the inactivated gas injected from the injection port 121, due to the recess 143.
  • the electron beam irradiation device 10 that irradiates the medical long-length member 300A with the electron beam includes an electron beam irradiation unit 110 having an exit surface 111 that emits the electron beam, an inactivation gas supply unit 120 having an injection port 121 that injects the inactivation gas, a partition section 140 that faces the exit surface 111, and a space 130a that is located between the exit surface 111 and the partition section 140, and a portion of the medical long-length member 300A is disposed in the space 130a.
  • the method includes a transport mechanism 150 that can be placed on the medical elongated member 300A, and a step of spraying an inactivated gas onto the medical elongated member 300A from an injection port 121 located on the side of the emission surface 111 while a part of the medical elongated member 300A is placed in the space 130a located between the emission surface 111 and the partition 140, and irradiating the medical elongated member 300A with an electron beam from the emission surface 111 while the medical elongated member 300A is in contact with the partition 140 with the inactivated gas.
  • the electron beam irradiation method can place a part of the medical elongated member 300A in the space 130a located between the exit surface 111 of the electron beam irradiation unit 110 that emits electron beams and the partition 140, and then spray inactivation gas onto the medical elongated member 300A from the nozzle 121 of the inactivation gas supply unit 120 located on the exit surface 111 side of the electron beam irradiation unit 110, thereby bringing the medical elongated member 300A into contact with the partition 140.
  • the electron beam irradiation method can maintain a constant distance between the exit surface 111 of the electron beam irradiation unit 110 and the medical elongated member 300A by bringing the medical elongated member 300A into contact with the partition 140.
  • the electron beam irradiation method irradiates electron beams from the emission surface 111 of the electron beam irradiation unit 110 to the medical elongated member 300A while maintaining a constant distance between the emission surface 111 of the electron beam irradiation unit 110 and the medical elongated member 300A, thereby preventing uneven curing of the lubricating coating layer 311a applied to the medical elongated member 300A.
  • the transport mechanism 150 includes a rail portion 151 and a gripping portion 153 that is movable along the rail portion 151 and is configured to be able to fix a part of the medical elongated member 300A
  • the irradiated object 300 is a medical elongated member 300A that includes a long main body portion 310 extending in the longitudinal direction and a hub portion 320 arranged at one end of the main body portion 310, and the main body portion 310 has a first region 311 that is coated with a lubricating coating layer 311a that is to be irradiated with the electron beam, and a second region 312 that is arranged closer to the one end side than the first region 311 and is not coated with the lubricating coating layer 311a, and includes irradiating the first region 311 with an electron beam while spraying an inactivated gas toward the medical elongated member 300A with the first region 311 being placed in the space 130a located between the
  • the electron beam irradiation method can prevent the main body 310 of the medical elongated member 300A from being inadvertently deformed or crushed while each operation is being performed by the electron beam irradiation device 10.
  • the electron beam irradiation method moves the medical elongated member 300A with only the hub portion 320 of the medical elongated member 300A fixed to the gripping portion 153, so the other end (tip) side of the medical elongated member 300A can be moved without being restrained by other members. Therefore, the electron beam irradiation method can smoothly move the other end side of the medical elongated member 300A inside and outside the chamber portion 130.
  • Fig. 14 shows a partition section 140A according to the first modified example
  • Fig. 15 shows a partition section 140B according to the second modified example.
  • the recess 143 of the partition 140 is formed between the wall 141 extending substantially perpendicularly from the bottom 144 (see Figures 7 and 8).
  • the structure or shape of the recess in the partition there are no particular limitations on the structure or shape of the recess in the partition.
  • the recess 143a can be formed between a pair of V-shaped walls 141a extending in a substantially straight line so as to widen toward the exit surface 111 of the electron beam irradiation unit 110 and the nozzle 121 of the inactivation gas supply unit 120 (arrow Z2 side).
  • the recess 143b can be formed between a pair of walls 141b extending in a curved line so as to widen toward the exit surface 111 of the electron beam irradiation unit 110 and the nozzle 121 of the inactivation gas supply unit 120.
  • the partitions 140A, 140B are configured to have recesses 143a, 143b formed in the cross-sectional shapes according to the modified examples shown in Figures 14 and 15, the medical elongated member 300A can be held in contact with the narrower bottom 144. Therefore, by configuring the partitions 140A, 140B to have recesses in the shapes shown in the modified examples, it is possible to effectively prevent the medical elongated member 300A from being displaced in the width direction (the direction of the arrows Y1-Y2 in the figure) when the medical elongated member 300A is brought into contact with the partition 140.
  • the partition 140 described in the above embodiment can set the depth of the recess 143 to be greater than the partitions 140A, 140B of the modified examples. Therefore, compared to the partitions 140A and 140B of each modification, the partition 140 can effectively prevent the medical elongated member 300A from slipping out of the recess 143 when a higher pressure inert gas is sprayed onto the medical elongated member 300A placed in the recess 143. From this perspective, it is more preferable that the electron beam irradiation device 10 is provided with the partition 140.
  • Second Embodiment 16 and 17 show an electron beam irradiation apparatus 10A according to the second embodiment.
  • FIG. 16 is a plan view of the electron beam irradiation device 10A
  • FIG. 17 is a side view of the electron beam irradiation device 10A as viewed from the direction of the arrow 17A shown in FIG. 16.
  • FIGS. 16 and 17 are partial cross-sectional views of the chamber section 130 so that the inside of the chamber section 130 can be seen.
  • the transport mechanism 150 of the electron beam irradiation device 10A was configured to transport the medical elongated member 300A while it was suspended in the direction of gravity.
  • the electron beam irradiation device 10 was configured such that the rail portion 151 extended in the up-down direction (vertical direction) and the entire device was laid out vertically.
  • the transport mechanism 150 provided in the electron beam irradiation device 10A according to this embodiment is configured to transport the medical elongated member 300A in the lateral direction (horizontal direction) that intersects with the direction of gravity.
  • the rail section 151 is installed on a predetermined stand 30.
  • the device body 20 is installed on the upper side (arrow Z1 side) of the chamber section 130.
  • FIG. 18 shows the state when electron beam irradiation is being performed by the electron beam irradiation device 10A.
  • the electron beam irradiation section 110 and the inactivation gas supply section 120 are disposed on the upper side (arrow Z1 side) of the chamber section 130.
  • the partition section 140 is disposed on the lower side (the side indicated by the arrow Z2) of the chamber section 130 so as to face the electron beam irradiation section 110 and the inactivation gas supply section 120.
  • the inactivation gas supply section 120 is disposed at a position closer to the hole section 135 side in the chamber section 130 than the electron beam irradiation section 110.
  • the inactivated gas supply unit 120 sprays inactivated gas toward the portion of the medical elongated member 300A that is located in the space 130a.
  • the portion of the medical elongated member 300A that is located in the space 130a comes into contact with the partition 140 as the inactivated gas is sprayed toward it.
  • the inactivated gas supply unit 120 sprays inactivated gas in an oblique direction from the upper side of the chamber portion 130 toward the lower side of the chamber portion 130. Therefore, the electron beam irradiation device 10A can efficiently press the medical elongated member 300A against the partition 140 that is located on the lower side of the chamber portion 130.
  • the electron beam irradiation device 10A can maintain a constant distance between the exit surface 111 of the electron beam irradiation unit 110 and the medical elongated member 300A at a position corresponding to the space 130a by contacting a part of the medical elongated member 300A with the partition portion 140.
  • the electron beam irradiation device 10 can prevent uneven curing at each part in the longitudinal direction of the medical elongated member 300A by emitting electron beams from the exit surface 111 of the electron beam irradiation unit 110 while maintaining a constant distance between the exit surface 111 of the electron beam irradiation unit 110 and the medical elongated member 300A.
  • a medical elongated member coated with a lubricating coating layer has been described as an example of an irradiated object.
  • the irradiated object to which the present invention is applied can be various members for which it is desired to maintain a constant distance between the emission surface of the electron beam irradiation unit and the irradiated object.
  • the irradiated object may be a medical device such as a stent or an injection puncture needle, or a member other than a medical device such as a string, rope, or hose.
  • the object to be hardened by irradiation with electron beams is not limited to only the lubricating coating layer, and may be, for example, an antibacterial coating layer, an antithrombotic coating layer, or a drug coating layer containing a material that hardens by irradiation with electron beams.
  • the intermediate coating layer may be the object to be hardened by irradiation with electron beams.
  • the object to be irradiated with the electron beam may be the surface of an object that does not have a coating layer, for the purpose of modifying the surface (e.g., making the surface hydrophilic, improving adhesion) or modifying the physical properties (e.g., improving heat resistance, improving mechanical strength).
  • the electron beam irradiation device of the present invention is not particularly limited in its specific configuration, as long as the irradiated object can be brought into contact with the partition by the inactivation gas injected from the inactivation gas supply unit, and the electron beam can be irradiated from the emission surface of the electron beam irradiation unit toward the irradiated object while the irradiated object is in contact with the partition.
  • the injection port 121 of the inactivation gas supply unit 120 is preferably inclined obliquely toward the first conveying direction d1 as in the first and second embodiments, but may be inclined obliquely toward the second conveying direction d2.
  • the inactivation gas supply unit 120 is disposed at a position on the arrow X2 side (the arrow d1 side where the conveying mechanism 150 moves the irradiated object 300) of the electron beam irradiation unit 110. Therefore, the structure and arrangement of each part of the electron beam irradiation device are not limited to the contents described in the specification.

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  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
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  • Apparatus For Disinfection Or Sterilisation (AREA)
PCT/JP2024/027706 2023-08-04 2024-08-02 電子線照射装置、及び電子線の照射方法 Pending WO2025033342A1 (ja)

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0560899A (ja) * 1991-09-02 1993-03-12 Nissin High Voltage Co Ltd 電子線照射装置
WO2005110507A1 (ja) * 2004-05-14 2005-11-24 Japan Stent Technology Co., Ltd. ガイドワイヤ
JP2010008387A (ja) * 2008-06-30 2010-01-14 Iwasaki Electric Co Ltd 電子線照射装置
JP2010520317A (ja) * 2007-02-28 2010-06-10 ディーエスエム アイピー アセッツ ビー．ブイ． 親水性コーティング
US20120319012A1 (en) 2011-06-20 2012-12-20 Harland Medical Systems, Inc. High throughput uv curing systems and methods of curing a plurality of articles
JP2020165941A (ja) * 2019-03-28 2020-10-08 トヨタ自動車株式会社 塗料硬化装置および塗料硬化方法
JP2023127578A (ja) 2022-03-01 2023-09-13 宏達國際電子股▲ふん▼有限公司 医療用画像検出システム、トレーニング方法及び医療解析方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0560899A (ja) * 1991-09-02 1993-03-12 Nissin High Voltage Co Ltd 電子線照射装置
WO2005110507A1 (ja) * 2004-05-14 2005-11-24 Japan Stent Technology Co., Ltd. ガイドワイヤ
JP2010520317A (ja) * 2007-02-28 2010-06-10 ディーエスエム アイピー アセッツ ビー．ブイ． 親水性コーティング
JP2010008387A (ja) * 2008-06-30 2010-01-14 Iwasaki Electric Co Ltd 電子線照射装置
US20120319012A1 (en) 2011-06-20 2012-12-20 Harland Medical Systems, Inc. High throughput uv curing systems and methods of curing a plurality of articles
JP2020165941A (ja) * 2019-03-28 2020-10-08 トヨタ自動車株式会社 塗料硬化装置および塗料硬化方法
JP2023127578A (ja) 2022-03-01 2023-09-13 宏達國際電子股▲ふん▼有限公司 医療用画像検出システム、トレーニング方法及び医療解析方法

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