Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
  • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
  • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
  • A01N25/06—Aerosols
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
  • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
  • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
  • A01N43/12—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings condensed with a carbocyclic ring
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
  • A01P7/00—Arthropodicides
  • A01P7/02—Acaricides
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
  • A01P7/00—Arthropodicides
  • A01P7/04—Insecticides

Definitions

• the present invention relates to an aerosol for controlling pests and mites, which is prepared by filling an aerosol concentrate containing a pest and mite control ingredient and a synergist, and a propellant, in an aerosol container equipped with a metered-dose injection valve, and to a method for controlling pests and mites using the same.
• Patent Document 1 reduces the number of pests by using the repellent effect of the aerosol product, but the repellent effect is not sufficiently high, and the lethal effect against crawling pests is also not sufficient.
• the present invention was made in consideration of the above circumstances, and aims to provide an aerosol for controlling pests and mites that is highly effective in controlling various pests and mites, and a method for controlling pests and mites.
• An aerosol for controlling pests and mites comprising an aerosol concentrate containing (A) a pest and mite control component and (B) a synergist, and a propellant, filled in an aerosol container equipped with a metered-dose injection valve,
• the synergist (B) is N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide.
• the aerosol for controlling pests and mites of this configuration is prepared by filling an aerosol concentrate containing (A) a pest and mite control component and (B) a synergist, together with a propellant, in an aerosol container equipped with a metered-dose injection valve.
• an aerosol concentrate containing (A) a pest and mite control component and (B) a synergist, together with a propellant, in an aerosol container equipped with a metered-dose injection valve.
• N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide as the synergist (B)
• the aerosol for controlling pests and mites exhibits excellent control effects against various pests and mites.
• N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide is preferably a mixture of Endo and Exo isomers in a molar ratio (Endo/Exo) of 30/70 to 70/30.
• the pest and mite control aerosol of this composition can enhance the control effect against various pests and mites by using a mixture of N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide with an isomer ratio (Endo/Exo) in the appropriate range described above.
• the pest and mite control component (A) preferably contains a hardly volatile pyrethroid compound having a vapor pressure at 30° C. of less than 1 ⁇ 10 ⁇ 4 mmHg (1.33 ⁇ 10 ⁇ 5 kPa).
• the pest and mite control aerosol of this composition by using a hardly volatile pyrethroid compound having a vapor pressure of less than 1 x 10-4 mmHg at 30°C as the pest and mite control component (A), it is possible to enhance the control effect against various pests and mites.
• the hardly volatile pyrethroid compound preferably contains fenothrin and/or permethrin.
• the aerosol for controlling pests and mites of this configuration uses fenothrin and/or permethrin as the non-volatile pyrethroid compound, which can further enhance the control effect against various pests and mites.
• the composition is configured so that 30% or more by mass of the (A) pest and mite control component adheres to the floor surface of the treatment space within one hour after spraying.
• the pest and mite control component adheres to the floor surface of the treatment space within one hour of spraying, so that not only is the control effect rapid against various pests and mites that wander around the floor surface, but it also exerts a control effect against pests and mites that hide behind furniture, electrical appliances, etc.
• the amount of the pest and mite control component (A) released into the air is set to 0.1 to 50 mg/ m3 .
• the control effect against various pests and mites can be further improved regardless of the volume of the treatment space.
• the volume of the metered injection valve per injection is preferably set to 0.1 to 3.0 mL.
• the volume of each injection from the metered injection valve is set to 0.1 to 3.0 mL, so by spraying the pest and mite control aerosol once or several times, the control effect against various pests and mites can be further improved regardless of the volume of the treatment space.
• the spray force at a spray distance of 5 cm is preferably set to 0.029 to 0.49 N at 25°C.
• the pest and mite control aerosol of this composition has a spray force of 0.029 to 0.49 N at a spray distance of 5 cm at 25°C, so most of the sprayed pest and mite control component (A) quickly settles and adheres to the floor surface of the treatment space, further enhancing the control effect against various pests and mites.
• the volume ratio (a/b) of the aerosol concentrate (a) to the propellant (b) is set to 15/85 to 60/40.
• the aerosol for controlling pests and mites of this configuration has a volume ratio (a/b) of the aerosol concentrate (a) and the propellant (b) set to 15/85 to 60/40, which can further enhance the control effect against various pests and mites.
• the aerosol for controlling pests and mites of this configuration can provide a constant-dose spray type aerosol for controlling crawling pests and/or indoor dust mites.
• the agent is capable of killing the crawling pests and/or house dust mites.
• the pest and mite control aerosol of this configuration is capable of killing crawling pests and/or indoor dust mites, so that crawling pests and/or indoor dust mites that attempt to escape from the treatment space can also be reliably controlled.
• a method for controlling pests and mites using an aerosol for controlling pests and mites comprising filling an aerosol concentrate containing (A) a pest and mite control component and (B) a synergist, and a propellant into an aerosol container equipped with a metered injection valve, the method comprising:
• the (B) synergist is N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide,
• the aerosol for controlling insects and mites is sprayed into the treatment space.
• an aerosol for controlling pests and mites which is prepared by filling an aerosol concentrate containing (A) a pest and mite control component and (B) a synergist, and a propellant into an aerosol container equipped with a metered dose injection valve, and when the aerosol for controlling pests and mites is sprayed into a treatment space, by selecting N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide as the synergist (B), excellent control effects against various pests and mites are achieved.
• the unit of content "w/v%” is synonymous with "g/100 ml", and when there is a notation " ⁇ " indicating a range in this specification, it is assumed that the upper and lower limits are included.
• the pest and mite control aerosol of this embodiment is prepared by filling an aerosol concentrate containing a pest and mite control component and a synergist, and a propellant, in an aerosol container equipped with a metered-dose injection valve.
• a known metered-dose injection valve can be used as the metered-dose injection valve.
• Control of pests and mites means control including repellency in addition to extermination based on knockdown effect or lethal effect on pests and mites
• the aerosol for controlling pests and mites of this embodiment is preferably one that kills crawling pests and/or indoor dust mites. By killing crawling pests and/or indoor dust mites, it is possible to reliably control crawling pests and/or indoor dust mites that try to escape from the treatment space.
• the aerosol concentrate is prepared as a composition containing the pest and mite control ingredient and a synergist in a solvent, and is then sealed in a pressure-resistant container together with a propellant.
• the pest and mite control component is a component having control activity against pests and mites.
• the pest and mite control component include pyrethroid compounds such as fenothrin, cyphenothrin, permethrin, cypermethrin, cyfluthrin, bifenthrin, fenpropathrin, tralomethrin, etofenprox, imiprothrin, resmethrin, transfluthrin, metofluthrin, profluthrin, telallethrin, furamethrin, momfluorothrin, dimefluthrin, mepafluthrin, heptafluthrin, deltamethrin, tralomethrin, allethrin, phthalthrin, prallethrin, and natural pyrethrins, silicon compounds such as silafluofen, and dichlorvos.
• organophosphorus compounds such as fenitrothion, carbamate compounds such as propoxur, neonicotinoid compounds such as dinotefuran, imidacloprid, and clothianidin, fipronil, indoxacarb, brofuranilide, methoxadiazone, amidoflumet, benzyl benzoate, phenyl salicylate, benzyl salicylate, dibutyl sebacate, dipropyl sebacate, dibutyl adipate, diethyl phthalate, dipropyl phthalate, dibutyl phthalate, p-menthane-3,8-diol, 3-iodo-2-propynyl butylcarbamate, and DEET.
• organophosphorus compounds such as fenitrothion
• carbamate compounds such as propoxur
• neonicotinoid compounds such as dinotefuran, imidacloprid, and clothianidin
• fipronil in
• the pest and mite control component is preferably a pyrethroid compound, and more preferably a pyrethroid compound having a vapor pressure of less than 1 ⁇ 10 ⁇ 4 mmHg (1.33 ⁇ 10 ⁇ 5 kPa) at 30° C.
• the pyrethroid compound having a vapor pressure of less than 1 ⁇ 10 ⁇ 4 mmHg (1.33 ⁇ 10 ⁇ 5 kPa) at 30° C. is preferably a pyrethroid compound having a vapor pressure of less than 1 ⁇ 10 ⁇ 4 mmHg (1.33 ⁇ 10 ⁇ 5 kPa).
• Examples of the pyrethroid compound having a vapor pressure of less than 1 ⁇ 10 ⁇ 4 mmHg (1.33 ⁇ 10 ⁇ 5 kPa) at 30° C. include fenothrin, cyphenothrin, permethrin, cypermethrin, cyfluthrin, bifenthrin, fenpropathrin, tralomethrin, etofenprox, imiprothrin, resmethrin, and the like, and fenothrin and/or permethrin are preferred. This can further enhance the control effect against various pests and mites.
• the pest and mite control component can be used alone or as a mixture of two or more kinds.
• optical isomers or geometric isomers based on asymmetric carbons exist in the acid component, alcohol portion, etc. of the pyrethroid compound, each of them and any mixture thereof are also included in the present invention.
• the content of the pest and mite control ingredient in the aerosol concentrate is preferably 1.0 to 80.0 w/v%, more preferably 5.0 to 75.0 w/v%, and even more preferably 10.0 to 70.0 w/v%.
• a synergist is a drug that does not have a control effect against pests and mites by itself, but enhances the control effect of a pest and mite control component by combining (mixing) it with a pest and mite control component.
• N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide is used as the synergist. This allows it to exert an excellent control effect against various pests and mites.
• N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide has two stereochemical structures (isomers): Endo and Exo.
• N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide can be used either as the Endo or Exo form alone, but it is useful to use a mixture in which the isomer ratio (Endo/Exo) between the Endo and Exo forms is adjusted to a molar ratio of 30/70 to 70/30, preferably 40/60 to 60/40.
• the isomer ratio between the Endo type and the Exo type was determined by the method described in “Chiral high-performance liquid chromatography of N-octyl bicycloheptene dicarboximide and confirming the isomer ratio" in Journal of Chromatography A (Vol. 864, 1999, pp. 271-281). It can be measured by the liquid chromatography analysis method described in “Liquid Chromatography-Tandem Mass Spectrometry and Two-Dimensional Nuclear Magnetic Resonance Spectroscopy” ("Matritory Studies using Liquid Chromatography-Tandem Mass Spectrometry and Two-Dimensional Nuclear Magnetic Resonance Spectroscopy”).
• Endo-type himic anhydride (5-norbornene-2,3-dicarboxylic anhydride) and carrying out the steps (1) to (3) below, a mixture of N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide in which the Endo-type and Exo-type are mixed in a specific isomer ratio (Endo/Exo) can be obtained.
• Endo-type himic anhydride (5-norbornene-2,3-dicarboxylic anhydride) is relatively inexpensive and is suitable as a raw material.
• Step (1) Endo-type anhydrous himic acid is isomerized (isomerization reaction).
• the anhydrous himic acid becomes a mixture of Endo-type and Exo-type.
• the isomer ratio (Endo/Exo) can be adjusted in the isomerization reaction.
• Step (2) The isomerization reaction product obtained in step (1) is condensed with 2-ethylhexylamine (condensation reaction), resulting in a mixture of Endo type N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide and Exo type N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide.
• Step (3) N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide is distilled from the condensation reaction solution containing the condensation reaction product obtained in step (2).
• N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide is separated from the condensation reaction solution containing unreacted materials, by-products, etc. in a mixed state of Endo type and Exo type.
• the isomer ratio (Endo/Exo) can also be further adjusted.
• step (1) Endo-type anhydrous himic acid is added to a reaction vessel without adding an organic solvent or with an organic solvent having a boiling point of 190 to 300°C, and heated at 190°C or higher for 30 minutes or more.
• a part of the Endo-type anhydrous himic acid is isomerized to produce Exo-type anhydrous himic acid.
• the ratio of Exo-type tends to increase as the reaction time is increased. Therefore, the isomer ratio (Endo/Exo) can be adjusted by adjusting the reaction time, and for example, the isomer ratio (Endo/Exo) between Endo-type and Exo-type can be adjusted to a range of 30/70 to 70/30.
• the organic solvent used in step (1) may be an aliphatic hydrocarbon solvent, an aromatic hydrocarbon solvent, an ester solvent, an ether solvent, or the like, and kerosene is particularly preferred. Kerosene is suitable as a solvent for the reactions in steps (1) and (2) and is easy to handle.
• step (2) the isomerization reaction liquid containing the isomerization reaction product obtained in step (1) is allowed to cool to room temperature. After cooling, 2-ethylhexylamine is added to the isomerization reaction liquid. If an organic solvent is added in step (1), 2-ethylhexylamine is added alone to the isomerization reaction liquid. If an organic solvent is not added in step (1), 2-ethylhexylamine is added to the isomerization reaction liquid together with water or an organic solvent having a boiling point of 110 to 150°C (toluene, xylene, etc.).
• the isomerization reaction product obtained in step (1) is subjected to a condensation reaction with 2-ethylhexylamine by heating at 90 to 160°C for 30 minutes or more.
• the isomerization reaction ratio between the Endo type and the Exo type (Endo/Exo) does not change significantly. Therefore, the isomer ratio (Endo/Exo) is basically determined by the isomerization reaction in step (1).
• step (2) if water or an organic solvent (kerosene, toluene, xylene, etc.) is used, the anhydrous himic acid adhering to the top of the reaction vessel is washed out and can be used for the condensation reaction, thereby increasing the yield of the reaction product. If water is added, safety in production can be increased.
• the pH of the condensation reaction liquid is adjusted to 5.5 to 7.0 using soda ash (sodium carbonate) as necessary, and then used in the next step (3).
• step (3) the condensation reaction liquid containing the condensation reaction product obtained in step (2) is put into a distillation apparatus, and the condensation reaction product, N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide, is distilled.
• the distillation temperature can be set to 160-170°C/3 mmHg (160-170°C/0.399 kPa).
• a normal distillation apparatus can be used as the distillation apparatus.
• the synergist content in the aerosol concentrate is preferably 0.01 to 30.0 w/v%, more preferably 0.1 to 20.0 w/v%, and even more preferably 0.5 to 10.0 w/v%.
• the mixing ratio (A/B) of the pest and mite control component (A) and the synergist (B) in the aerosol concentrate is preferably 1/5 to 100/1 by mass, more preferably 1/4 to 100/1, even more preferably 1/3 to 50/1, and particularly preferably 1/1 to 30/1.
• the aerosol concentrate is usually used in a state where a pest and mite control component and a synergist are dissolved or dispersed in an organic solvent or water as a solvent.
• organic solvent include hydrocarbon solvents such as lower alcohols having 2 to 3 carbon atoms, normal paraffins (e.g., product names: Neothiosol, DA-1, etc.), and isoparaffins (e.g., product names: Isopar M, Isopar G, Isopar H, Isopar L, IP Solvent 1620, IP Solvent 2028, IP Solvent 2835, IP Clean LX, Idemitsu Supersol FP25, Idemitsu Supersol LA25, Isozole, etc.), ester solvents such as higher fatty acid esters having 16 to 20 carbon atoms, such as isopropyl myristate (IPM) and hexyl laurate, glycol ether solvents having 3 to 10 carbon atoms, and ketone solvents.
• ethanol isopropanol
• the solvent may be used alone or as a mixture of two or more kinds.
• the pest and mite control aerosol of this embodiment is sprayed in small amounts, so there is no major problem with fire, but a water-based formulation can also be used.
• the amount of water contained in the aerosol concentrate is appropriately about 10 to 70 v/v%.
• a small amount of nonionic surfactant may be added as a solubilizing aid, as long as it does not affect the spray pattern of the spray particles.
• nonionic surfactants include ethers such as polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, and polyoxyethylene alkyl amino ethers, fatty acid esters such as polyethylene glycol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene glycerin fatty acid esters, polyoxyethylene styrenated phenol, and polyalkanolamides of fatty acids, and among these, ethers are preferred.
• ethers such as polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, and polyoxyethylene alkyl amino ethers
• fatty acid esters such as polyethylene glycol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene glycerin fatty acid esters, polyoxyethylene sty
• the aerosol concentrate may also be appropriately blended with antifungal agents, antibacterial agents, bactericides, fragrances, deodorants, stabilizers, antistatic agents, antifoaming agents, excipients, etc.
• antifungal agents, antibacterial agents, and bactericides include hinokitiol, 2-mercaptobenzothiazole, 2-(4-thiazolyl)benzimidazole, 5-chloro-2-methyl-4-isothiazolin-3-one, triforine, 3-methyl-4-isopropylphenol, and ortho-phenylphenol.
• fragrances include orange oil, lemon oil, lavender oil, peppermint oil, eucalyptus oil, citronella oil, lime oil, yuzu oil, jasmine oil, cypress oil, green tea essential oil, limonene, ⁇ -pinene, linalool, geraniol, phenylethyl alcohol, amylcinnamic aldehyde, cumin aldehyde, benzyl acetate, green leaf alcohol and green leaf aldehyde, which are known as the "green scent.”
• propellants examples include liquefied petroleum gases (LPG) such as propane, normal butane, and isobutane, liquefied gases such as normal pentane, isopentane, dimethyl ether (DME), and HFO1234ze, and compressed gases such as nitrogen gas, carbon dioxide gas, nitrous oxide, and compressed air.
• LPG liquefied petroleum gases
• DME dimethyl ether
• HFO1234ze liquefied gases
• compressed gases such as nitrogen gas, carbon dioxide gas, nitrous oxide, and compressed air.
• the above propellants can be used alone or in a mixed state, but those containing LPG as the main component are easy to use. It is preferable to use the propellant by adjusting the gauge pressure (20°C) to 0.10 to 0.70 MPa.
• the volume ratio (a/b) of the aerosol concentrate (a) to the propellant (b) is preferably 10/90 to 70/30, more preferably 15/85 to 60/40, even more preferably 20/80 to 55/45, and most preferably 20/80 to 50/50.
• the internal pressure of the aerosol container is not particularly limited, but is preferably set to 0.60 MPa or less at 25° C., more preferably 0.15 to 0.60 MPa, even more preferably 0.20 to 0.55 MPa, and particularly preferably 0.30 to 0.55 MPa.
• the internal pressure of the aerosol container of the pest and mite control aerosol is measured by the following procedure. (1) The insect and mite control aerosol is immersed in a thermostatic water tank at 25 ⁇ 0.5° C. for 30 minutes. (2) Next, the insect and mite control aerosol is held upright, the stem of the aerosol container is airtightly inserted into the insertion port of the pressure gauge, and the measured pressure is read to two decimal places. (3) The above measurement should be performed once, and the measured value should be the internal pressure value without rounding it off.
• the spray volume of the metered dose spray valve is set to 0.1 to 3.0 mL, preferably 0.2 to 1.0 mL, and more preferably 0.2 to 0.9 mL. If the spray volume is within the above range, the amount of pest and mite control component released will be appropriate, for example, about 0.1 to 50 mg/ m3 , by spraying the pest and mite control aerosol once or several times, and the control effect against various pests and mites can be improved.
• the spray force of the pest and mite control aerosol of this embodiment is set to 3 to 50 gf (0.029 to 0.49 N) at 25°C and 5 cm away from the nozzle, preferably 5 to 40 gf (0.049 to 0.39 N), more preferably 10 to 35 gf (0.098 to 0.34 N), and particularly preferably 12 to 30 gf (0.118 to 0.29 N). If the spray force is within the above range, most of the pest and mite control component will quickly settle and adhere to the floor surface of the treatment space, enhancing the control effect against various pests and mites. Such spray force can be appropriately adjusted depending on the composition of the aerosol concentrate, the internal pressure of the aerosol container, the shape of the nozzle, etc. In this embodiment, the spray force of the pest and mite control aerosol is measured using a digital force gauge (FGC-0.5, manufactured by Nidec-Shimpo Corporation).
• FGC-0.5 digital force gauge
• the shape of the nozzle, the container, the operation button, etc. can be selected as appropriate.
• it can be designed as a tabletop type with a button that is pressed from above to spray and a nozzle that faces diagonally upwards, or it can be designed as a small, portable container.
• the number, shape, and size of the nozzle of the pest and mite control aerosol of this embodiment are not particularly limited.
• the number of nozzles may be one or more than two, but from the viewpoint of simple and low-cost manufacturing, the number of nozzles is preferably one.
• the shape (cross-sectional shape) of the nozzle may be circular, elliptical, polygonal, or indefinite.
• the opening area of the nozzle is preferably 0.05 to 8.0 mm 2 , more preferably 0.1 to 4.0 mm 2 , and even more preferably 0.2 to 3.0 mm 2.
• the size of the nozzle is preferably 0.3 mm or more, more preferably 0.4 mm or more, and even more preferably 0.6 mm or more.
• the nozzle diameter is preferably 3.0 mm or less, more preferably 2.0 mm or less, and even more preferably 1.8 mm or less.
• the nozzle of the pest and mite control aerosol of this embodiment is preferably a nozzle that faces diagonally upwards.
• the container of the pest and mite control aerosol of this embodiment may be made of metal such as aluminum or tinplate, synthetic resin such as polyethylene terephthalate, or pressure-resistant glass. When the container is made of synthetic resin or pressure-resistant glass, it may be translucent or transparent.
• the shape of the container may be a normal cylinder or a deformed shape.
• the operation button of the pest and mite control aerosol of this embodiment may be a push-down type button or a trigger type button.
• the pest and mite control aerosol of this embodiment is sprayed into the air in a treatment space, so that the amount of pest and mite control components released into the air is preferably set to 0.1 to 50 mg/m 3 , more preferably set to 0.5 to 50 mg/m 3 , even more preferably set to 1.0 to 40 mg/m 3 , and particularly preferably set to 5.0 to 30 mg/m 3.
• the aerosol concentrate is sprayed into the air of the treatment space so that the amount of pest and mite control components released is 0.1 to 50 mg/m 3 , 30% or more of the pest and mite control components will diffuse and adhere to the floor surface of the treatment space by mass within 1 hour after spraying.
• the pest and mite control components "diffuse and adhere to the floor surface of the treatment space" means that the floor surface is in a state where the pest and mite control components attached thereto can exert a pest and mite control effect, and it is not necessary that the pest and mite control components are physically attached to the floor surface.
• 30% or more of the pest and mite control component is dispersed and attached to the floor surface of the treatment space, so that the pest and mite control aerosol of this embodiment can enhance the control effect against various pests and mites.
• the control effect is quickly exerted against various pests and mites wandering on the floor surface, but the control effect is also exerted against pests and mites hiding in the shadows of furniture, electrical appliances, etc.
• the number of sprays, the spray volume, etc. are appropriately set so that the amount of pest and mite control component released into the air is 0.1 to 50 mg/m 3 , and the same control effect can be obtained regardless of the volume of the treatment space.
• the frequency of use of the pest and mite control aerosol of this embodiment it is preferable to apply it at an appropriate time according to the occurrence frequency and situation of pests and mites so that the amount of pest and mite control component released is within the above range.
• pests and mites examples include crawling pests (for example, cockroaches such as American cockroaches, Smoky cockroaches, and German cockroaches, bedbugs such as bedbugs (cimex), Taiwanese bedbugs (Nettite cimex), stink bugs such as brown stink bugs, ants such as black mountain ants, red-legged ants, brown ants, house ants, red fire ants, and fire ants, spiders such as huntsman spiders, spotted house spiders, and redback spiders, millipedes, centipedes such as the Japanese bush warbler, pillbugs, woodlouse, termites, and Japanese white ants, Examples of pests include termites such as ants, caterpillars, house mites, ticks, and fleas), flying pests (e.g., mosquitoes such as Culex
• the aerosol for controlling pests and mites of the present embodiment is particularly effective against ants such as black mountain ants, red-spotted ants, brown ants, house ants, red fire ants, and fire ants, spiders such as huntsman spiders, spotted house spiders, and redback spiders, cockroaches such as American cockroaches, Smoky cockroaches, and German cockroaches, bedbugs such as bedbugs (bedbugs) and Taiwanese bedbugs (Nettite bedbugs), and house mites.
• the pest and mite control method of this embodiment is carried out using the above-mentioned pest and mite control aerosol, and involves performing a spray treatment in which the pest and mite control aerosol is sprayed into a treatment space. According to the pest and mite control method of this embodiment, by using the pest and mite control aerosol of this embodiment, excellent control effects can be achieved against various pests and mites.
• the treatment space is preferably an indoor space, but may be an outdoor space as long as there is almost no air movement.
• the volume of the treatment space is not particularly limited, but examples thereof include a narrow space of less than 2.0 m 3 , a narrow space of 2.0 to 18.8 m 3 , an indoor space with a volume of 18.8 to 33.3 m 3 (area 7.5 to 13.3 m 2 , height 2.2 to 3.0 m ) equivalent to a room of 4.5 to 8 tatami mats, and a wide indoor space with a volume of 33.3 to 66.6 m 3 (area 13.3 to 26.6 m 2 , height 2.2 to 3.0 m ) equivalent to a room of 8 to 16 tatami mats .
• the indoor space is a large one having a volume of 18.8 to 33.3 m 3 (area 7.5 to 13.3 m 2 , height 2.2 to 3.0 m), which corresponds to a room of 4.5 to 8 tatami mats, and more preferably an indoor space having a volume of 18.8 to 33.3 m 3 (area 7.5 to 13.3 m 2 , height 2.2 to 3.0 m).
• the amount of pest and mite control ingredient released into the air will be 0.1 to 50 mg/m 3 .
• the number of sprays, spray volume, etc. can be appropriately set so that the amount of pest and mite control components released into the air of the indoor space is 0.1 to 50 mg/ m3 according to the volume of the indoor space, thereby obtaining a similar control effect regardless of the volume of the indoor space.
• the frequency of implementation of the pest and mite control method of this embodiment is preferably applied at an appropriate time depending on the frequency and situation of occurrence of pests and mites so that the amount of pest and mite control components released is within the above range.
• indoor spaces include closets, storage rooms, chests of drawers, cupboards, toilets, bathrooms, storage rooms, living rooms, dining rooms, warehouses, inside cars, furniture, and furniture gaps.
• the spray direction (elevation angle) of the pest and mite control aerosol is preferably diagonally upward, i.e., 0 to 60° relative to the horizontal plane, and more preferably 30 to 60°.
• the spray particles are widely dispersed throughout the air in the treatment space, and the pest and mite control component (A) contained in the spray particles can be allowed to settle and adhere to the floor surface of the treatment space.
• an excellent control effect is achieved against various pests and mites.
• N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide is referred to as "Compound S”.
• 6 mL of the obtained aerosol concentrate and 24 mL of liquefied petroleum gas (LPG) were pressurized and filled (product internal pressure: 0.37 MPa/25°C) into an aerosol container equipped with a metered dose injection valve (0.4 mL per injection) to obtain the aerosol for controlling pests and mites of Example 1.
• LPG liquefied petroleum gas
• Compound S was obtained by carrying out an isomerization reaction, a condensation reaction, and a distillation according to the manufacturing method shown in steps (1) to (3) above, so that the isomer ratio between the Endo type and the Exo type (Endo/Exo) was the value shown in Table 1.
• the molar ratio of the Endo type and the molar ratio of the Exo type shown in Table 1 are calculated as the ratio (percentage) of the number of moles of the Endo type and the Exo type to the total number of moles of the Endo type and the Exo type, respectively.
• the total volume (a+b) of the aerosol concentrate (a) and the propellant (b) is 30 mL, and the volume ratio (a/b) of the aerosol concentrate (a) and the propellant (b) is 20/80.
• the number of nozzles is set to 1, the shape (cross-sectional shape) of the nozzle is circular, the opening area is 0.38 mm 2 , and the nozzle size (nozzle diameter) is 0.7 mm.
• the pest and mite control aerosol has a spray force of 14 gf (0.14 N) at 25°C and a distance of 5 cm from the nozzle, and the amount of pest and mite control components released into the air is 7.68 mg/m 3 .
• Aerosols for controlling insects and mites of Examples 2 to 15 and aerosols of Comparative Examples 1 to 4 were prepared according to the formulations shown in Table 1, following the procedure of Example 1.
• Compound S was obtained by carrying out an isomerization reaction, a condensation reaction, and a distillation according to the production method shown in the above-mentioned steps (1) to (3) so that the isomer ratio between Endo type and Exo type (Endo/Exo) was the value shown in Table 1.
• PBO represents piperonyl butoxide
• IPA represents isopropanol
• IPM represents isopropyl myristate.
• Neothiosol is normal paraffin
• Isopar M is isoparaffin.
• the total volume (a+b) of the aerosol concentrate (a) and the propellant (b) was set to 30 mL, and the volume ratio (a/b) of the aerosol concentrate (a) and the propellant (b) was set to the value shown in Table 1.
• the same fixed-dose injection valve as in Example 1 was used, and the number of nozzles, nozzle shape (cross-sectional shape), opening area, and nozzle size (nozzle diameter) were set to the same as in Example 1.
• the aerosol of Comparative Example 2 which does not contain any pest or mite control ingredients and uses an aerosol concentrate containing only the synergist N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide, showed almost no lethal effect against the house dust mites Dermatophagoides farinae and Tyrophagus putrescentiae, which are house dust mites, or the crawling pest German cockroach.
• the aerosol of Comparative Example 3 which used piperonyl butoxide in combination with the pest and mite control ingredient, had a higher lethality rate of 50-60% against house dust mites, Dermatophagoides farinae and Tyrophagus putrescentiae, than the aerosol of Comparative Example 1, which did not use a synergist, but the lethality was insufficient compared to the aerosols for pest and mite control of Examples 1-15, which used N-(2-ethylhexyl)-bicyclo[2,2,1]-hept-5-ene-2,3-dicarboximide in combination with the synergist.
• the pest and mite control aerosol and pest and mite control method of the present invention are highly effective against various pests and mites, and can therefore be used for the purpose of pest and mite control in a wide range of applications, not just indoors.

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