WO2024077508A1 - 阻隔蓝光的隐形眼镜及其制备方法 - Google Patents

阻隔蓝光的隐形眼镜及其制备方法 Download PDF

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Publication number
WO2024077508A1
WO2024077508A1 PCT/CN2022/124788 CN2022124788W WO2024077508A1 WO 2024077508 A1 WO2024077508 A1 WO 2024077508A1 CN 2022124788 W CN2022124788 W CN 2022124788W WO 2024077508 A1 WO2024077508 A1 WO 2024077508A1
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Prior art keywords
dye
blue light
light blocking
contact lens
yellow
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PCT/CN2022/124788
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English (en)
French (fr)
Inventor
张汉宜
陈君涵
徐从诰
汪暐哲
林昱宏
高婉楹
刘力豪
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晶硕光学股份有限公司
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Priority to PCT/CN2022/124788 priority Critical patent/WO2024077508A1/zh
Publication of WO2024077508A1 publication Critical patent/WO2024077508A1/zh

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/04—Acids; Metal salts or ammonium salts thereof
    • C08F220/06—Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/01—Use of inorganic substances as compounding ingredients characterized by their specific function
    • C08K3/013—Fillers, pigments or reinforcing additives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes

Definitions

  • the present disclosure relates to ophthalmic products and preparation methods thereof, and in particular to contact lenses that block blue light and preparation methods thereof.
  • blue light with a wavelength between 380 nanometers and 500 nanometers has a shorter wavelength and greater energy, it is more likely to cause damage to the eyes, especially the retina, than light with other wavelengths.
  • the retina needs to undergo photochemical reactions at any time to produce vision, and the reaction process consumes oxygen. Under the stimulation of blue light, many free radicals are easily generated, which damage cells.
  • the cell membranes of the photoreceptor cells of the retina contain many fatty acids, which are also easily generated under the stimulation of blue light, causing damage or death of retinal cells.
  • anti-blue light lenses on the market are yellow in color. Although they have anti-blue light function, they are not aesthetically pleasing. When consumers wear anti-blue light lenses, their eyelids (corneoscleral contact area, limbus) will have a jaundice feeling, which reduces consumers' willingness to wear them. In view of this, it is urgent to develop anti-blue light lenses that can block blue light and have aesthetics to enhance their commercial value.
  • the present disclosure provides a blue light blocking contact lens, which is formed by curing a composition.
  • the composition includes: a blue light blocking component formed by mixing or reacting a first hydrophilic monomer and a yellow dye, a first colored dye component formed by mixing or reacting a second hydrophilic monomer and a first colored dye, at least one third hydrophilic monomer, a crosslinking agent, and an initiator.
  • the first colored dye includes a green dye, a cyan dye, a blue dye, an orange dye, a red dye, a black dye, or a combination thereof.
  • the first hydrophilic monomer, the second hydrophilic monomer and the third hydrophilic monomer are independently selected from the group consisting of N-vinylpyrrolidone (NVP), 2-hydroxyethyl methacrylate (HEMA), glycidyl methacrylate (GMA), glycerol monomethacrylate (GMMA), methacrylic acid (methacrylic acid), acrylic acid (acrylic acid), N,N-dimethyl acrylamide (DMA), N,N-diethyl acrylamide (N,N-diethyl acrylamide), N-ethyl-N-methyl acetamide (N-vinyl-N-methyl acetamide), 2-methacryloyloxyethyl phosphorylcholine and 2-hydroxybutyl methacrylate.
  • NRP N-vinylpyrrolidone
  • HEMA 2-hydroxyethyl methacrylate
  • GMMA glycerol monomethacrylate
  • methacrylic acid methacryl
  • the composition further includes a second colored dye component, which is formed by mixing or reacting a fourth hydrophilic monomer with a second colored dye, wherein the second colored dye includes a green dye, a cyan dye, a blue dye, an orange dye, a red dye, a black dye or a combination thereof.
  • a second colored dye component which is formed by mixing or reacting a fourth hydrophilic monomer with a second colored dye, wherein the second colored dye includes a green dye, a cyan dye, a blue dye, an orange dye, a red dye, a black dye or a combination thereof.
  • the fourth hydrophilic monomer is selected from the group consisting of N-vinyl pyrrolidone, 2-hydroxyethyl methacrylate, glycidyl methacrylate, glycerol monomethacrylate, methacrylic acid, acrylic acid, N,N-dimethylacrylamide, N,N-diethylacrylamide, N-ethyl-N-methylacetamide, 2-methacryloyloxyethyl phosphorylcholine and 2-hydroxybutyl methacrylate.
  • the yellow dye is 0.01 wt % to 2 wt %
  • the first colored dye is 0.01 wt % to 2 wt %.
  • the yellow dye is present in an amount of 0.01 to 2 parts by weight, and the first colored dye is present in an amount of greater than 0 parts by weight and less than or equal to 2 parts by weight.
  • the weight ratio of the yellow dye to the first hydrophilic monomer is 1:0.1 to 1:10.
  • the weight ratio of the first colored dye to the second hydrophilic monomer is 1:0.1 to 1:10.
  • the yellow dye is selected from the group consisting of Reactive Yellow 15, Reactive Yellow 86, and Reactive Yellow 83.
  • the first colored dye has an ethylenically-base polymerizable group, a sulfonic group, a sulfonyl group, a sulfonate group, an amide group, or a combination thereof.
  • the first colored dye is selected from the group consisting of Reactive Blue 4, Reactive Blue 19, Reactive Blue 21, Reactive Blue 69, Reactive Blue 163, Reactive Blue 246, Reactive Blue 246, Reactive Blue 247, Reactive Red 11, Reactive Red 180, Reactive Black 5, Reactive Orange 78, and Pigment Green 7.
  • the present disclosure provides a method for preparing a blue light blocking contact lens of any of the aforementioned embodiments, comprising the following operations.
  • the method further comprises: before heating the first mixed solution to 25° C. to 80° C., adding an alkaline substance and an inhibitor to the first mixed solution.
  • the method further comprises: before heating the second mixed solution to 25° C. to 80° C., adding an alkaline substance and an inhibitor to the second mixed solution.
  • the present disclosure provides a blue light blocking contact lens, which is formed by curing a composition.
  • the composition includes: a blue light blocking component, at least one hydrophilic monomer, a crosslinking agent, and an initiator.
  • the blue light blocking component is formed by mixing or reacting glycerol monomethacrylate (GMMA) and a yellow dye.
  • GMMA glycerol monomethacrylate
  • the yellow dye is in an amount of 0.01 wt % to 2 wt %.
  • the yellow dye is selected from the group consisting of Reactive Yellow 15, Reactive Yellow 86, and Reactive Yellow 83.
  • the weight ratio of the yellow dye to glycerol monomethacrylate is 1:0.1 to 1:10.
  • the present disclosure provides a method for preparing a blue light blocking contact lens according to any of the aforementioned embodiments, comprising the following operations: Mixing glycerol monomethacrylate and yellow dye to form a mixed solution; Heating the mixed solution to 25° C. to 80° C. for 0.5 to 24 hours to form a blue light blocking component; Curing the blue light blocking component, at least one hydrophilic monomer, a crosslinking agent, and an initiator.
  • the method further comprises: before heating the mixed solution to 25° C. to 80° C., adding an alkaline substance and an inhibitor to the mixed solution.
  • FIG. 1 is a contact lens obtained by the preparation method according to various embodiments of the present disclosure.
  • 2 to 7 are transmittance spectra of contact lenses according to various embodiments of the present disclosure.
  • blue light shows that high-energy blue light of 460 nanometers to 500 nanometers helps memory and cognitive functions, and makes people feel happy, so blue light is beneficial blue light.
  • Blue light of 380 nanometers to 460 nanometers can easily cause damage to human eyes, so it is harmful blue light.
  • the present disclosure provides contact lenses that block blue light, which have good anti-blue light properties.
  • the contact lenses of the present disclosure have a blocking rate of 5% to 30% for harmful blue light with a wavelength of 380 nanometers to 460 nanometers.
  • the contact lenses of the present disclosure are colored contact lenses, which are, for example, red, orange, yellow, green, blue or gray. This colored contact lens has anti-blue light properties and good aesthetics.
  • the present disclosure also provides a method for preparing contact lenses that block blue light.
  • the dye is pretreated with a hydrophilic monomer, that is, the two are mixed or reacted to increase the solubility of the dye in the composition forming the contact lenses, thereby improving the color rendering and blue light blocking rate of the contact lenses.
  • adding the pretreated dye to the composition can effectively improve the compatibility of the formula, enhance the vividness of the lens color, enhance the uniformity of the lens color, and enhance the blue light blocking rate of the lens, thereby obtaining a contact lens with multiple colors.
  • the contact lens of the present disclosure can be a hydrogel contact lens or a silicone hydrogel contact lens.
  • the present disclosure provides a contact lens that blocks blue light, which is formed by a solidified composition.
  • This composition includes: a blue light blocking component formed by mixing or reacting a first hydrophilic monomer and a yellow dye, a first colored dye component formed by mixing or reacting a second hydrophilic monomer and a first colored dye, at least one third hydrophilic monomer, a crosslinker, and an initiator.
  • This blue light blocking component is formed by pre-treating the yellow dye with a first hydrophilic monomer.
  • the first colored dye component is formed by pre-treating the first colored dye with a second hydrophilic monomer, wherein the first colored dye includes a green dye, a cyan dye, a blue dye, an orange dye, a red dye, a black dye, or a combination thereof. Since both the yellow dye and the first colored dye have been pre-treated, the solubility of both in the composition and the compatibility of both with other components can be greatly improved, so that the contact lens has good color rendering and blue light blocking rate.
  • the composition includes one or more blue light blocking components, and the multiple blue light blocking components include different pre-treated yellow dyes.
  • the composition for preparing contact lenses may include one or more different colored dye components, such as two, three or four.
  • the composition includes the first and second colored dye components, the second colored dye component is formed by mixing or reacting the fourth hydrophilic monomer with the second colored dye, wherein the second colored dye includes a green dye, a cyan dye, a blue dye, an orange dye, a red dye, a black dye or a combination thereof.
  • the colors of the first colored dye component and the second colored dye component may be the same or different.
  • Contact lenses of different colors can be formulated by mixing a variety of colored dye components.
  • the composition includes a blue light blocking component (containing a pretreated yellow dye) and two colored dye components (containing a pretreated blue dye and a red dye), which can be used to form purple contact lenses.
  • the composition further includes a third colored dye component, the color of which may be the same or different from the first colored dye component and/or the second colored dye component, and the implementation of the third colored dye component may refer to the implementation of the second colored dye component, and will not be repeated.
  • the first hydrophilic monomer, the second hydrophilic monomer, the third hydrophilic monomer and the fourth hydrophilic monomer are independently selected from the group consisting of N-vinyl pyrrolidone, 2-hydroxyethyl methacrylate, glycidyl methacrylate, glycerol monomethacrylate, methacrylic acid, acrylic acid, N,N-dimethylacrylamide, N,N-diethylacrylamide, N-ethyl-N-methylacetamide, 2-methacryloyloxyethyl phosphorylcholine and 2-hydroxybutyl methacrylate.
  • the yellow dye is 0.01wt% to 2wt%
  • the first colored dye is 0.01wt% to 2wt%.
  • the yellow dye is, for example, 0.01, 0.05, 0.1, 0.5, 1, 1.5 or 2wt%.
  • the first colored dye is, for example, 0.01, 0.05, 0.1, 0.5, 1, 1.5 or 2wt%.
  • the yellow dye is 0.01wt% to 2wt%
  • the total of the first colored dye and the second colored dye is 0.01wt% to 2wt%.
  • the total is, for example, 0.01, 0.05, 0.1, 0.5, 1, 1.5 or 2wt%.
  • the yellow dye is 0.01 to 2 weight parts, and the first colored dye is greater than 0 weight parts and less than or equal to 2 weight parts.
  • the yellow dye is, for example, 0.01, 0.05, 0.1, 0.5, 1, 1.5 or 2 weight parts.
  • the first colored dye is, for example, 0.01, 0.05, 0.1, 0.5, 1, 1.5 or 2 weight parts.
  • the contact lens can have good color rendering and blue light blocking rate, and the wearer can still maintain good visual experience.
  • the first hydrophilic monomer, the second hydrophilic monomer and the third hydrophilic monomer are 30 to 99 weight parts. In other embodiments, the first hydrophilic monomer, the second hydrophilic monomer, the third hydrophilic monomer and the fourth hydrophilic monomer are 30 to 99 weight parts.
  • the weight ratio of the yellow dye to the first hydrophilic monomer is 1:0.1 to 1:10, and this range enables the two to have the best compatibility.
  • the weight ratio is, for example, 1:0.1, 1:0.5, 1:1, 1:2, 1:5 or 1:10.
  • the weight ratio of the first colored dye to the second hydrophilic monomer is 1:0.1 to 1:10, and this range enables the two to have the best compatibility.
  • the weight ratio is, for example, 1:0.1, 1:0.5, 1:1, 1:2, 1:5 or 1:10.
  • the weight ratio of the second colored dye to the fourth hydrophilic monomer is 1:0.1 to 1:10, and this range enables the two to have the best compatibility.
  • the weight ratio is, for example, 1:0.1, 1:0.5, 1:1, 1:2, 1:5 or 1:10.
  • the yellow dye, the first colored dye and the second colored dye can have good solubility and good compatibility in the composition, so that the contact lens has good color rendering properties.
  • the yellow dye is selected from the group consisting of Reactive Yellow 15, Reactive Yellow 86, and Reactive Yellow 83.
  • the first colored dye and the second colored dye independently have a vinyl polymerizable group, a sulfonic acid group, a sulfonyl group, a sulfonate group, an amide group, or a combination thereof.
  • the first colored dye and the second colored dye are independently selected from the group consisting of reactive blue 4, reactive blue 19, reactive blue 21, reactive blue 69, reactive blue 163, reactive blue 246, reactive blue 247, reactive red 11, reactive red 180, reactive black, reactive orange 78, and pigment green.
  • the crosslinking agent is selected from the group consisting of ethylene glycol dimethacrylate, diethylene glycol dimethacrylate, triethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, allyl methacrylate, ethylene glycol diallyl ether, The group consisting of triethylene glycol diallyl ether, tetraethylene glycol diallyl tetravinylethylene glycol diene, 1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione and 1,1,1-trimethylolpropane trimethacrylate.
  • the initiator is selected from the group consisting of phosphine-oxide-based initiators and titanium metallocene-based initiators.
  • the phosphine-oxide-based initiator is selected from the group consisting of diphenyl(2,4,6-triphenyl)phosphine oxide, bis(2,4,6-trimethylbenzoyl)phenyl phosphine oxide, and bis(2,6-dimethoxylbenzoyl)(2,4,4-trimethylpentyl)phosphine oxide.
  • the metallocene titanium compound initiator includes dicyclopentadienyl bis[2,4-difluoro-3-(1-pyrrolyl)phenyl]titanium.
  • the composition for preparing a contact lens that blocks blue light further includes a UV blocking monomer.
  • the UV blocking monomer is selected from the group consisting of a monomer having benzophenone and a monomer having benzotriazole.
  • the monomer of benzophenone includes, for example, 4-methacryloxy-2-hydroxy benzophenone, 4-(2-acryloxyethoxy)-2-hydroxy benzophenone, or a combination thereof.
  • the present disclosure provides a method for preparing a blue light blocking contact lens of any of the aforementioned embodiments, comprising the following operations.
  • a first hydrophilic monomer and a yellow dye are mixed to form a first mixed solution.
  • the first mixed solution is heated to 25°C to 80°C for 0.5 to 24 hours to form a blue light blocking component.
  • a second hydrophilic monomer and a first colored dye are mixed to form a second mixed solution.
  • the second mixed solution is heated to 25°C to 80°C for 0.5 to 24 hours to form a first colored dye component. If the above heating temperature is higher than 80°C, too many by-products may be generated, resulting in a decrease in the dye bonding rate and a decrease in the blue light blocking rate of the lens.
  • a composition containing a blue light blocking component, a first colored dye component, at least one third hydrophilic monomer, a crosslinking agent and an initiator is cured to form a contact lens.
  • the temperature at which the first mixed solution or the second mixed solution is heated is 25, 35, 45, 55, 65, 75 or 80°C.
  • the heating time of the first mixed solution or the second mixed solution is 0.5, 1, 5, 10, 15, 20 or 24 hours.
  • the contact lens is a hydrogel contact lens or a silicone hydrogel contact lens.
  • the composition further includes a silicon-containing monomer.
  • the above-mentioned curing operation is to inject the composition into the interlayer of the plastic male mold and the female mold, polymerize the composition through ultraviolet light, and solidify to form a solid lens. Subsequently, the solid lens is hydrated and relaxed, placed in a contact lens packaging solution, and then sealed and sterilized at high temperature to obtain a contact lens that blocks blue light.
  • the method further includes: before heating the first mixed solution, adding an alkaline substance and an inhibitor to the first mixed solution, so that the heating operation is to heat the first mixed solution containing the first hydrophilic monomer, the yellow dye, the alkaline substance and the inhibitor. Therefore, after heating, the first hydrophilic monomer and the yellow dye will be bonded together to form a blue light blocking component.
  • the yellow dye is pre-treated by the "synthesis method" to increase the solubility of the blue light blocking component in the composition, thereby improving the color rendering and blue light blocking rate of the contact lens.
  • the pH value of the first mixed solution is 10 to 14. The pH value is, for example, 10, 11, 12, 13 or 14.
  • the inhibitor includes hydroquinone monomethyl ether (Mequinol, MeHQ).
  • the alkaline substance includes sodium hydroxide (NaOH).
  • the first mixed solution does not contain water. Under the experimental conditions of the same dye addition amount, the reaction in an anhydrous environment can make the blue light blocking rate of the lens higher; on the other hand, the reaction in a water environment has a lower blue light blocking rate of the lens.
  • Reactive Yellow 15 will form Reactive Yellow 15 with a vinyl group in the presence of sodium hydroxide (NaOH) and an inhibitor (MeHQ), which will then react with GMMA to form a blue light blocking component.
  • Reactive Yellow 15 pre-treated with GMMA has better solubility and compatibility in the composition of contact lenses, thereby improving its color rendering and blue light blocking rate.
  • the following reaction process is applicable to dyes having an ethylenically-base polymerizable group, a sulfonic group, a sulfonyl group, a sulfonate group, an amide group, or a combination thereof.
  • the first mixed solution does not add alkaline substances and inhibitors, such as sodium hydroxide and MeHQ, so in the heated mixture, the first hydrophilic monomer and the yellow dye do not form a bond, and this mixture is a blue light blocking component.
  • the yellow dye is pre-treated by the "mixing method" to increase the solubility of the subsequent blue light blocking component in the composition, thereby improving the color rendering of the contact lens. It is worth noting that if the untreated yellow dye, hydrophilic monomer, cross-linking agent and initiator are directly mixed when preparing the contact lens composition, the yellow dye will have insufficient compatibility, which will cause insufficient color rendering of the contact lens and poor anti-blue light effect.
  • the first mixed solution does not contain water.
  • the method further includes: before heating the second mixed solution to 25°C to 80°C, adding an alkaline substance and an inhibitor to the second mixed solution, so that the heating operation is to heat the second mixed solution containing the second hydrophilic monomer, the first colored dye, the alkaline substance and the inhibitor. Therefore, after heating, the second hydrophilic monomer and the first colored dye will be bonded together to form a first colored dye component.
  • the first colored dye is pretreated by a "synthesis method" to increase the solubility of the first colored dye component in the composition, thereby improving the color rendering of the contact lens.
  • the pH value of the second mixed solution is 10 to 14. The pH value is, for example, 10, 11, 12, 13 or 14.
  • the inhibitor includes hydroquinone monomethyl ether.
  • the alkaline substance includes sodium hydroxide.
  • the second mixed solution does not contain water. Under the experimental conditions of the same dye addition amount, the reaction in an anhydrous environment can make the blue light blocking rate of the lens higher; on the other hand, the reaction in a water environment has a lower blue light blocking rate of the lens.
  • the second mixed solution does not add alkaline substances and inhibitors, such as sodium hydroxide and MeHQ, so in the heated mixture, the second hydrophilic monomer and the first colored dye component do not form a bond, and this mixture is the first colored dye component.
  • the first colored dye is pre-treated by the "mixing method" to improve the solubility of the subsequent first colored dye component in the composition, thereby improving the color rendering of the contact lens. It is worth noting that if the untreated first colored dye, hydrophilic monomer, cross-linking agent and initiator are directly mixed when preparing the contact lens composition, the first colored dye will have a problem of insufficient compatibility, which will cause insufficient color rendering of the contact lens.
  • the second mixed solution does not contain water.
  • the method further includes mixing a fourth hydrophilic monomer with a second colored dye to form a third mixed solution, heating the third mixed solution to 25°C to 80°C for 0.5 hours to 24 hours to form a second colored dye component.
  • the second colored dye component is added to the composition, and then a curing operation is performed. If the above heating temperature is higher than 80°C, too many by-products may be generated, thereby causing a decrease in the dye bonding rate and a decrease in the blue light blocking rate of the lens.
  • the method further includes: before heating the third mixed solution to 25°C to 80°C, adding an alkaline substance and an inhibitor to the third mixed solution. In some embodiments, no alkaline substance and an inhibitor are added to the third mixed solution.
  • the implementation of the third mixed solution can refer to the implementation of the second mixed solution, and will not be repeated.
  • the silicon-containing monomers include 3-[tris(trimethylsiloxy)silyl]propyl methacrylate (TRIS, 3-[Tris(trimethylsiloxy)silyl]propyl methacrylate), (3-methacryloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methylsilane (SiGMA, (3-Methacryloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methylsilane), 3-methacryloxypropyltris(trimethylsiloxy)silane, 3-acryloxypropyltris(trimethylsiloxy)silane tris(trimethylsiloxy)silane), 3-acrylamide propyltris(trimethylsiloxy)silane, 3-Methacrylamide propyltris(trimethylsiloxy)silane, 3-Vinylacrylamide propyltris(trimethylsiloxy)silane, ⁇ -acrylamidopropyl– ⁇ -butylpoly
  • the present disclosure provides a blue light blocking contact lens, which is formed by curing a composition.
  • the composition includes: a blue light blocking component, at least one hydrophilic monomer, a crosslinking agent, and an initiator.
  • the blue light blocking component is formed by mixing or reacting glycerol monomethacrylate (GMMA) and a yellow dye.
  • GMMA glycerol monomethacrylate
  • the contact lens is a hydrogel contact lens or a silicone hydrogel contact lens.
  • the composition further includes a silicon-containing monomer.
  • the yellow dye is selected from the group consisting of Reactive Yellow 15, Reactive Yellow 86 and Reactive Yellow 83. In some embodiments, based on 100 wt % of the composition, the yellow dye is 0.01 wt % to 2 wt %. The yellow dye is, for example, 0.01, 0.05, 0.1, 0.5, 1, 1.5 or 2 wt %. When the weight percentage falls within the above range, the contact lens can have good color rendering and good blue light blocking rate, and the wearer can still maintain a good visual experience.
  • the weight ratio of the yellow dye to glycerol monomethacrylate is 1:0.1 to 1:10.
  • the weight ratio is, for example, 1:0.1, 1:0.5, 1:1, 1:2, 1:5 or 1:10.
  • the yellow dye can have good solubility and good compatibility in the composition, so that the contact lens has good color rendering and blue light blocking rate.
  • the present disclosure provides a method for preparing a blue light blocking contact lens of any of the aforementioned embodiments, comprising the following operations.
  • Heat the mixed solution to 25°C to 80°C for 0.5 to 24 hours to form a blue light blocking component.
  • Curing a composition containing a blue light blocking component, at least one hydrophilic monomer, a crosslinking agent, and an initiator to form a contact lens.
  • the temperature of heating the mixed solution is 25, 35, 45, 55, 65, 75, or 80°C.
  • the heating time of the mixed solution is 0.5, 1, 5, 10, 15, 20, or 24 hours.
  • For the curing operation please refer to the aforementioned embodiment and will not be repeated.
  • the method further comprises: before heating the mixed solution to 25°C to 80°C, adding an alkaline substance and an inhibitor to the mixed solution.
  • the pH value of the mixed solution is 10 to 14.
  • the pH value is, for example, 10, 11, 12, 13 or 14.
  • the inhibitor comprises hydroquinone monomethyl ether.
  • the alkaline substance comprises sodium hydroxide.
  • no alkaline substance and inhibitor are added to the mixed solution.
  • the mixed solution does not contain water. Under the experimental conditions of the same dye addition amount, reacting in an anhydrous environment can make the blue light blocking rate of the lens higher; on the other hand, reacting in an aqueous environment, the blue light blocking rate of the lens is lower.
  • the contact lens is a hydrogel contact lens or a silicone hydrogel contact lens.
  • the contact lens is a hydrogel contact lens or a silicone hydrogel contact lens.
  • the manufacturing of contact lenses includes the following operations: injecting the hydrogel or silicone hydrogel composition of the blue light blocking contact lens into the interlayer of the plastic male mold and the female mold, polymerizing the composition through ultraviolet light, and solidifying it to form a solid lens. After taking out the solid lens, it is hydrated and expanded, placed in the contact lens packaging liquid, and then sealed and sterilized at high temperature (125°C, 30 minutes), completing the manufacturing of the blue light blocking colorful contact lens.
  • the hydrogel composition of the blue light blocking contact lens comprises one or more hydrophilic monomers, a blue light blocking component, a crosslinker and an initiator.
  • the silicone hydrogel composition of the blue light blocking contact lens comprises one or more hydrophilic monomers, a blue light blocking monomer, a crosslinker, an initiator and a silicon-containing monomer.
  • the hydrophilic monomer comprises GMMA, HEMA or a combination thereof.
  • the crosslinker comprises ethylene glycol dimethacrylate.
  • the initiator comprises bis(2,4,6-trimethylbenzoyl)-phenylphosphine oxide.
  • the hydrogel or silicone hydrogel composition may further comprise one colored component or two colored components.
  • the blue light blocking component comprises a yellow dye pretreated by a "synthesis method” or a "mixing method".
  • the colored component comprises a green dye, a blue dye, an orange dye, a red dye or a black dye pretreated by a "synthesis method” or a “mixing method”.
  • the “synthesis method” is to heat a mixture containing a hydrophilic monomer glycerol monomethacrylate (GMMA), a dye, an alkaline substance sodium hydroxide (NaOH) and an inhibitor MeHQ at 25°C to 80°C for at least 12 hours.
  • the “synthesis method” is to heat a mixture containing a hydrophilic monomer glycerol monomethacrylate (GMMA) and a dye at 25°C to 80°C for at least 12 hours.
  • the weight ratio of the dye to GMMA is 1:10
  • MeHQ is about 0.07wt%
  • sodium hydroxide is about 1wt%.
  • Figure 1 includes dark red lens R1, brown red lens R2, orange red lens O1, orange lens O2, orange yellow lens O3, amber lens Y1, dark yellow lens Y2, yellow lens Y3, yellow green lens G1, green lens G2, bright green lens G3, blue lens B1, gray blue lens B2, indigo lens P1, purple lens P2 and gray lens G.
  • the lenses in Figure 1 correspond to the lenses of Examples 8 to 23 in Tables 1 and 2, respectively.
  • Figures 2 to 7 respectively show the curves r1, r2, o1, o2, o3, y1, y2, y3, g1, g2, g3, b1, b2, p1, p2 and g corresponding to the light absorption rate of the above-mentioned lenses, and the curve BLANK of the light absorption rate of the blank group of lenses without dye.
  • the present disclosure can form colorful contact lenses with various colors, and all of them have bright colors, and can have both anti-blue light effect and wear aesthetics.
  • the light transmittance of the contact lens is measured using an ultraviolet/visible light spectrometer, and the average blue light transmittance (T%) from 380 nanometers to 460 nanometers is calculated and captured through the machine program, that is, the average harmful blue light transmittance, and then the average blue light transmittance (T%) is subtracted from 100%, and the blue light blocking rate in Tables 1 and 2, that is, the harmful blue light blocking rate, can be obtained.
  • blue light blocking rate % 100% - blue light transmittance (T%).
  • the blue light blocking contact lenses of Examples 1 to 25 have a harmful blue light blocking rate ranging from 5.57% to 26.27%. Therefore, the blue light blocking contact lenses of the present disclosure can substantially achieve a harmful blue light blocking rate of 5% to 30%.
  • Examples 1 to 24 can produce hydrogel contact lenses, while Example 25 can produce silicone hydrogel contact lenses.
  • Example 25 adds about 0.100wt% of the dye Reactive Yellow 15 and uses a synthetic method for pretreatment, which can make the lens have a blue light blocking rate of 26.27%. It can be seen that the pretreatment method of the present disclosure can achieve a better blue light blocking effect in the silicone hydrogel composition system.
  • the blocking rate of harmful blue light is mainly affected by the concentration of yellow dye and pretreatment, and other non-yellow dyes have little effect.
  • Table 3 lists the examples prepared using only Reactive Yellow 15.
  • Example 2 pre-treats Active Yellow 15 through the mixing method M1, so that the blue light blocking rate of the lens is 13.05%.
  • Example 7 pre-treats Active Yellow 15 through the synthesis method M2, which can greatly increase the blue light blocking rate of the lens to 25.29%, which is 12.24% higher.
  • the blue light blocking rate of the lens of Example 7 is about twice that of the lens of Example 2. It can be seen that under the same yellow dye ratio, pre-treating the dye through the synthesis method can greatly improve the lens's blocking effect on harmful blue light.
  • Example 8 only adds 0.085wt% of Reactive Yellow 15 and pre-treats it with the synthesis method M2, and the blue light blocking rate of the lens can reach 14.66%.
  • Example 2 adds 0.150wt% of Reactive Yellow 15 and pre-treats it with the mixing method M1, and the blue light blocking rate of the lens is 13.05%. It can be seen that by pre-treating the dye with the synthesis method, the lens can still have a good blue light blocking rate when a small amount of dye is added. Comparing Example 8 with Example 2, the addition amount of Example 8 can be reduced by 0.065wt%, and in the hydration process, the product made by Example 8 can also reduce the amount of dye washed and dissolved, reducing process wastewater.
  • Example 6 Comparing Example 6 and Example 7, if the lens needs to achieve a blue light blocking rate of 25%, Example 6 needs to use 0.301wt% of Reactive Yellow 15, while Example 7 only uses 0.150wt% of Reactive Yellow 15, and the addition amount can be reduced by 0.151wt%. From this, we can see that pre-treating the dye through a synthetic method can greatly enhance the lens's ability to block harmful blue light.
  • the present disclosure provides a contact lens that blocks blue light and a method for preparing the same.
  • a contact lens that blocks blue light
  • a method for preparing the same By pre-treating dyes of various colors with hydrophilic monomers by a “synthesis method” or a “mixing method”, and then mixing them with other materials for preparing contact lenses (such as other hydrophilic monomers, crosslinking agents, initiators or silicon-containing monomers) and then curing them to form lenses, contact lenses with good color rendering and bright colors can be obtained, and the contact lenses also have good anti-blue light effects.
  • the "synthesis method” can more effectively improve the solubility and compatibility of the dye in the composition, and can further reduce process wastewater.
  • the method of the present disclosure can improve the feasibility of colorful lens manufacturing by using a combination of multiple dyes.

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Abstract

提供两种阻隔蓝光的隐形眼镜，其是由固化不同组成物而形成。第一种组成物包括：由第一亲水性单体与黄色染料混合而成或反应而成的阻隔蓝光成分、由第二亲水性单体与第一有色染料混合而成或反应而成的第一有色染料成分、至少一个第三亲水性单体、交联剂及起始剂。第一有色染料包括绿色染料、青色染料、蓝色染料、橘色染料、红色染料、黑色染料或其组合。第二种组成物包括：阻隔蓝光成分、至少一个亲水性单体、交联剂及起始剂。阻隔蓝光成分是由甘油单甲基丙烯酸酯与黄色染料混合而成或反应而成。此外，提供制备上述隐形眼镜的方法。由于提升了染料在组合物中的溶解度和相容性，上述隐形眼镜可具有良好的抗蓝光效果及显色性。

Description

阻隔蓝光的隐形眼镜及其制备方法 技术领域
本揭示内容是关于眼用产品及其制备方法，特别是关于阻隔蓝光的隐形眼镜及其制备方法。
背景技术
近年来由于3C产品蓬勃发展，许多智能型装置，如手机荧幕、平板显示器、电脑荧幕、发光二极管灯(light-emitting diode lamp,LED lamp)灯等已广泛被应用于人们的生活中。然而这些智能型装置的的背景光源含有蓝光，当人眼长时间直视蓝光会对视网膜造成伤害。
由于波长介于380纳米至500纳米的蓝光波长较短，具有较大的能量，比起具有其他波长的光线更容易造成眼睛的伤害，尤其容易损伤视网膜。视网膜随时需要进行光化学反应产生视觉，反应过程需消耗氧气，在蓝光刺激下，容易产生许多自由基而伤害细胞。并且，视网膜的感光细胞的细胞膜内含有许多脂肪酸，在蓝光刺激下，也容易产生自由基，造成视网膜细胞受损或死亡。
目前市面上的抗蓝光镜片大多呈现黄色，虽有抗蓝光功能，但美观性不佳。消费者在配戴抗蓝光镜片时，眼睛轮部(角巩膜接触处、角巩膜缘)有黄疸病态感，因而降低消费者的配戴意愿。有鉴于此，目前亟需开发出能够阻隔蓝光且具有美观性的抗蓝光镜片，以提升其商业价值。
发明内容
本揭示内容提供一种阻隔蓝光的隐形眼镜，其是由固化组成物而形成。组成物包括：由第一亲水性单体与黄色染料混合而成或反应而成的阻隔蓝光成分、由第二亲水性单体与第一有色染料混合而成或反应而成的第一有色染料成分、至少一个第三亲水性单体、交联剂及起始剂。第一有色染料包括绿色染料、青色染料、蓝色染料、橘色染料、红色染料、黑色染料或其组合。
在一些实施方式中，第一亲水性单体、第二亲水性单体及第三亲水性 单体是独立选自于由N-乙烯吡咯烷酮(N-vinylpyrrolidone,NVP)、2-羟基乙基甲基丙烯酸酯(2-hydroxyethyl methacrylate,HEMA)、甲基丙烯酸缩水甘油酯(glycidyl methacrylate,GMA)、甘油单甲基丙烯酸酯(glycerol monomethacrylate,GMMA)、甲基丙烯酸(methacrylic acid)、丙烯酸(acrylic acid)、N,N-二甲基丙烯酰胺(N,N-dimethyl acrylamide,DMA)、N,N-二乙基丙烯酰胺(N,N-diethyl acrylamide)、N-乙基-N-甲基乙酰胺(N-vinyl-N-methyl acetamide)、2-甲基丙烯酰氧乙基磷酰胆碱(2-methacryloyloxyethyl phosphorylcholine)及甲基丙烯酸2-羟基丁酯(2-hydroxybutyl methacrylate)所组成的群组。
在一些实施方式中，组成物更包括第二有色染料成分，第二有色染料成分是由第四亲水性单体与第二有色染料混合而成或反应而成，其中第二有色染料包括绿色染料、青色染料、蓝色染料、橘色染料、红色染料、黑色染料或其组合。
在一些实施方式中，第四亲水性单体是选自于由N-乙烯吡咯烷酮、2-羟基乙基甲基丙烯酸酯、甲基丙烯酸缩水甘油酯、甘油单甲基丙烯酸酯、甲基丙烯酸、丙烯酸、N,N-二甲基丙烯酰胺、N,N-二乙基丙烯酰胺、N-乙基-N-甲基乙酰胺、2-甲基丙烯酰氧乙基磷酰胆碱及甲基丙烯酸2-羟基丁酯所组成的群组。
在一些实施方式中，以组成物为100wt％计，黄色染料为0.01wt％至2wt％，第一有色染料为0.01wt％至2wt％。
在一些实施方式中，黄色染料为0.01重量分至2重量分，第一有色染料为大于0重量分且小于等于2重量分。
在一些实施方式中，黄色染料与第一亲水性单体的重量比为1：0.1至1：10。
在一些实施方式中，第一有色染料与第二亲水性单体的重量比为1：0.1至1：10。
在一些实施方式中，黄色染料是选自于由活性黄15(Reactive Yellow 15)、活性黄86(Reactive Yellow 86)及活性黄83(Reactive Yellow 83)所组成的群组。
在一些实施方式中，第一有色染料具有乙烯基可聚合基团(ethylenically-base polymerizable group)、磺酸基(sulfonic group)、磺酰基 (sulfonyl group)、磺酸盐基(sulfonate group)、酰胺基(amide group)或其组合。
在一些实施方式中，第一有色染料是选自于由活性蓝4(Reactive Blue 4)、活性蓝19(Reactive Blue 19)、活性蓝21(Reactive Blue 21)、活性蓝69(Reactive Blue 69)、活性蓝163(Reactive Blue 163)、活性蓝246(Reactive Blue 246)、活性蓝247(Reactive Blue 247)、活性红11(Reactive Red 11)、活性红180(Reactive Red 180)、活性黑(Reactive Black 5)、活性橙78(Reactive Orange 78)及颜料绿(Pigment Green 7)所组成的群组。
本揭示内容提供一种制备前述任一实施方式的阻隔蓝光的隐形眼镜的方法，包括以下操作。混合第一亲水性单体与黄色染料，形成第一混合液。将第一混合液加热至25℃至80℃，加热时间为0.5小时至24小时，以形成阻隔蓝光成分。混合第二亲水性单体与第一有色染料，形成第二混合液。将第二混合液加热至25℃至80℃，加热时间为0.5小时至24小时，以形成第一有色染料成分。固化阻隔蓝光成分、第一有色染料成分、至少一个第三亲水性单体、交联剂及起始剂。
在一些实施方式中，方法更包括：在将第一混合液加热至25℃至80℃前，将碱性物质及抑制剂加入第一混合液中。
在一些实施方式中，方法更包括：在将第二混合液加热至25℃至80℃前，将碱性物质及抑制剂加入第二混合液中。
本揭示内容提供一种阻隔蓝光的隐形眼镜，其是由固化组成物而形成。组成物包括：阻隔蓝光成分、至少一个亲水性单体、交联剂及起始剂。阻隔蓝光成分是由甘油单甲基丙烯酸酯(glycerol monomethacrylate,GMMA)与黄色染料混合而成或反应而成。
在一些实施方式中，以组成物为100wt％计，黄色染料为0.01wt％至2wt％。
在一些实施方式中，黄色染料是选自于由活性黄15(Reactive Yellow 15)、活性黄86(Reactive Yellow 86)及活性黄83(Reactive Yellow 83)所组成的群组。
在一些实施方式中，黄色染料与甘油单甲基丙烯酸酯的重量比为1：0.1至1：10。
本揭示内容提供一种制备前述任一实施方式的阻隔蓝光的隐形眼镜的方法，包括以下操作。混合甘油单甲基丙烯酸酯与黄色染料，形成混合液。 将混合液加热至25℃至80℃，加热时间为0.5小时至24小时，以形成阻隔蓝光成分。固化阻隔蓝光成分、至少一个亲水性单体、交联剂及起始剂。
在一些实施方式中，方法更包括：在将混合液加热至25℃至80℃前，将碱性物质及抑制剂加入混合液中。
附图的简要说明
参照附加图式，可以通过阅读以下实施方式的详细描述更充分理解本揭示内容。
图1是根据本揭示内容各种实施方式的制备方法得到的隐形眼镜。
图2至图7是根据本揭示内容各种实施方式的隐形眼镜的穿透率光谱图。
【主要元件符号说明】
B1:蓝色镜片
B2:灰蓝色镜片
G:灰色镜片
G1:黄绿色镜片
G2:绿色镜片
G3:亮绿色镜片
O1:橘红色镜片
O2:橘色镜片
O3:橘黄色镜片
P1:靛色镜片
P2:紫色镜片
R1:暗红色镜片
R2:棕红色镜片
Y1:琥珀色镜片
Y2:暗黄色镜片
Y3:黄色镜片
BLANK、b1、b2、g、g1、g2、g3、o1、o2、o3、p1、p2、r1、r2、y1、y2、y3:曲线
实现发明的最佳方式
以下通过特定的具体实施例来说明本揭示内容有关「阻隔蓝光的隐形眼镜」的实施方式，所属技术领域中具有通常知识者可由本揭示内容所公开的内容了解本揭示内容的优点与效果。本揭示内容可通过其他不同的具体实施例加以施行或应用，本揭示内容中的各项细节也可基于不同观点与应用，在不悖离本揭示内容的构思下进行各种修改与变更。以下的实施方式将进一步详细说明本揭示内容的相关技术内容，但所公开的内容并非用以限制本揭示内容的保护范围。
除非另外定义，否则本文中使用的所有技术及科学术语，都具有与所属技术领域中具有通常知识者通常所理解含义相同的含义。当术语以单数形式出现时，涵盖此术语的复数形式。
除非另有指示，否则本文中提到的所有百分比都为重量百分比。当提供一系列上、下限范围时，涵盖所提到的范围的所有组合，如同明确列出各组合。在本文中，由「一数值至另一数值」表示的范围，是一种避免在说明书中一一列举该范围中的所有数值的概要性表示方式。因此，某一特定数值范围的记载，涵盖该数值范围内的任意数值以及由该数值范围内的任意数值界定出的较小数值范围，如同在说明书中明文写出该任意数值和该较小数值范围一样。
虽然下文中利用一系列的操作或步骤来说明在此揭露的方法，但是这些操作或步骤所示的顺序不应被解释为本揭示内容的限制。例如，某些操作或步骤可以按不同顺序进行及/或与其它步骤同时进行。此外，并非必须执行所有绘示的操作、步骤及/或特征才能实现本揭示内容的实施方式。此外，在此所述的每一个操作或步骤可以包含数个子步骤或动作。
关于蓝光的研究结果显示460纳米至500纳米的高能量蓝光有助于记忆和认知功能，让心情愉快，故此蓝光为有益蓝光。而380纳米至460纳米的蓝光容易造成人眼伤害，故为有害蓝光。本揭示内容提供阻隔蓝光的隐形眼镜，其具有良好的抗蓝光特性，在一些实施方式中，本揭示内容的隐形眼镜对于波长为380纳米至460纳米的有害蓝光的阻隔率为5％至30％。并且，本揭示内容的隐形眼镜为彩色隐形眼镜，其例如为红色、橘色、黄色、绿色、蓝色或灰色，此彩色隐形眼镜具有抗蓝光特性且具有良好美观性。本揭示内容亦提供阻隔蓝光的隐形眼镜的制备方法，在固化制备隐形 眼镜的组合物前，先以亲水性单体对于染料进行预处理，亦即混合两者或使两者发生反应，以提升染料在形成隐形眼镜的组成物中的溶解度，从而提升隐形眼镜的显色性及阻隔蓝光率。换言之，经预处理的染料加入组成物中可有效提高配方相容性、提升镜片色彩鲜艳程度、镜片色彩均匀度及提升镜片对于蓝光的阻隔率，从而得到色彩多元的隐形眼镜。此外，本揭示内容的隐形眼镜可为水胶隐形眼镜或硅水胶隐形眼镜。以下将分别描述本揭示内容的各种实施方式。
本揭示内容提供一种阻隔蓝光的隐形眼镜，其是由固化组成物而形成。此组成物包括：由第一亲水性单体与黄色染料混合而成或反应而成的阻隔蓝光成分、由第二亲水性单体与第一有色染料混合而成或反应而成的第一有色染料成分、至少一个第三亲水性单体、交联剂及起始剂。此阻隔蓝光成分是通过第一亲水性单体对黄色染料进行预处理所形成。另一方面，第一有色染料成分是通过第二亲水性单体对第一有色染料进行预处理所形成，其中第一有色染料包括绿色染料、青色染料、蓝色染料、橘色染料、红色染料、黑色染料或其组合。由于黄色染料及第一有色染料皆有经过预处理，故可大幅提升两者在组成物中的溶解度及两者与其他成分的相容性，从而使隐形眼镜具有良好的显色性及阻隔蓝光率。在一些实施方式中，组成物包括一种或多种阻隔蓝光成分，此多种阻隔蓝光成分包括经预处理的不同黄色染料。
用于制备隐形眼镜的组成物可包括一种或是多种不同的有色染料成分，例如两种、三种或四种。在一些实施方式中，组成物包括第一及第二有色染料成分，第二有色染料成分是由第四亲水性单体与第二有色染料混合而成或反应而成，其中第二有色染料包括绿色染料、青色染料、蓝色染料、橘色染料、红色染料、黑色染料或其组合。第一有色染料成分与第二有色染料成分的颜色可为相同或不同。可通过混合多种有色染料成分，调配出不同颜色的隐形眼镜。举例来说，组成物包括阻隔蓝光成分(含有经预处理的黄色染料)及两种有色染料成分(含有经预处理的蓝色染料及红色染料)，可用于形成紫色隐形眼镜。在另一些实施方式中，组成物更包括第三有色染料成分，其颜色可与第一有色染料成分及/或第二有色染料成分相同或不同，第三有色染料成分的实施方式可参照第二有色染料成分的实施方式，不再赘述。
在一些实施方式中，第一亲水性单体、第二亲水性单体、第三亲水性单体及第四亲水性单体是独立选自于由N-乙烯吡咯烷酮、2-羟基乙基甲基丙烯酸酯、甲基丙烯酸缩水甘油酯、甘油单甲基丙烯酸酯、甲基丙烯酸、丙烯酸、N,N-二甲基丙烯酰胺、N,N-二乙基丙烯酰胺、N-乙基-N-甲基乙酰胺、2-甲基丙烯酰氧乙基磷酰胆碱及甲基丙烯酸2-羟基丁酯所组成的群组。
在一些实施方式中，以组成物为100wt％计，黄色染料为0.01wt％至2wt％，第一有色染料为0.01wt％至2wt％。黄色染料例如为0.01、0.05、0.1、0.5、1、1.5或2wt％。第一有色染料例如为0.01、0.05、0.1、0.5、1、1.5或2wt％。在一些实施方式中，以组成物为100wt％计，黄色染料为0.01wt％至2wt％，第一有色染料及第二有色染料的总合为0.01wt％至2wt％。总合例如为0.01、0.05、0.1、0.5、1、1.5或2wt％。当重量百分比落于上述范围内，可使隐形眼镜具有良好显色性及良好的阻隔蓝光率，且配戴者仍可以保持良好视觉感受。
在一些实施方式中，黄色染料为0.01重量分至2重量分，第一有色染料为大于0重量分且小于等于2重量分。黄色染料例如为0.01、0.05、0.1、0.5、1、1.5或2重量分。第一有色染料例如为0.01、0.05、0.1、0.5、1、1.5或2重量分。当重量分落于上述范围内，可使隐形眼镜具有良好显色性及阻隔蓝光率，且配戴者仍可以保持良好视觉感受。在一些实施方式中，第一亲水性单体、第二亲水性单体及第三亲水性单体为30至99重量份。在另一些实施方式中，第一亲水性单体、第二亲水性单体、第三亲水性单体及第四亲水性单体为30至99重量份。
在一些实施方式中，黄色染料与第一亲水性单体的重量比为1：0.1至1：10，此范围能够使二者具有最佳的相容性。重量比例如为1：0.1、1：0.5、1：1、1：2、1：5或1：10。在一些实施方式中，第一有色染料与第二亲水性单体的重量比为1：0.1至1：10，此范围能够使二者具有最佳的相容性。重量比例如为1：0.1、1：0.5、1：1、1：2、1：5或1：10。在一些实施方式中，第二有色染料与第四亲水性单体的重量比为1：0.1至1：10，此范围能够使二者具有最佳的相容性。重量比例如为1：0.1、1：0.5、1：1、1：2、1：5或1：10。当重量分落于上述范围内，可使黄色染料、第一有色染料及第二有色染料在组成物中具有良好溶解度和良好相容性，从而使隐形眼镜具有良好显色性。
在一些实施方式中，黄色染料是选自于由活性黄15、活性黄86及活性黄83所组成的群组。
在一些实施方式中，第一有色染料及第二有色染料独立具有乙烯基可聚合基团、磺酸基、磺酰基、磺酸盐基、酰胺基或其组合。举例来说，第一有色染料及第二有色染料是独立选自于由活性蓝4、活性蓝19、活性蓝21、活性蓝69、活性蓝163、活性蓝246、活性蓝247、活性红11、活性红180、活性黑、活性橙78及颜料绿所组成的群组。
在一些实施方式中，交联剂是选自于由乙二醇二甲基丙烯酸酯(ethylene glycol dimethacrylate)、二乙二醇二甲基丙烯酸酯(diethylene glycol dimethacrylate)、三乙二醇二甲基丙烯酸酯(triethylene glycol dimethacrylate)、四乙二醇二甲基丙烯酸酯(tetraethylene glycol dimethacrylate)、甲基丙烯酸烯丙酯(allyl methacrylate)、乙二醇基二烯丙基醚(ethylene glycol diallyl ether)、三乙二醇基二烯丙基醚(triethylene glycol diallyl ether)、四乙二醇基二烯丙基醚(tetraethylene glycol diallyl tetravinylethylene glycol diene)、1,3,5-三烯丙基-1,3,5-三肼-2,4,6(1H,3H,5H)三酮(1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione)及三羟甲基丙烷三甲基丙烯酸酯(1,1,1-trimethylolpropane trimethacrylate)所组成的群组。
在一些实施方式中，起始剂是选自于由膦氧化物起始剂(phosphine-oxide-based initiator)及茂金属钛化合物起始剂(titanium metallocene-based initiator))所组成的群组。举例来说，膦氧化物起始剂是选自于由苯基双(2,4,6-三甲基苯甲酰基)氧化膦(diphenyl(2,4,6-triphenyl)phosphine oxide)、双(2,4,6-三甲基苯甲酰基)-苯基膦氧化物(bis(2,4,6-trimethylbenzoyl)phenyl phosphine oxide)及双(2,6-二甲氧基苯甲酰基)(2,4,4-三甲基戊基)膦氧化物(bis(2,6-dimethoxylbenzoyl)(2,4,4-trimethylpentyl)phosphine oxide)所组成的群组。举例来说，茂金属钛化合物起始剂包括二茂双[2,4-二氟-3-(1-吡咯)苯基]钛(dicyclopentadienyl bis[2,4-difluoro-3-(1-pyrrolyl)phenyl]titanium)。
在一些实施方式中，用于制备阻隔蓝光的隐形眼镜的组成物更包括阻隔紫外光单体。举例来说，阻隔紫外光单体是选自于由具有二苯基甲酮(benzophenone)的单体及具有苯并三唑(benzotriazole)的单体所组成的群组。二苯基甲酮的单体例如包括4-甲基丙烯酰氧基-2-羟基二苯基甲酮 (4-methacryloxy-2-hydroxy benzophenone)、4-(2-丙烯酰氧基乙氧基)-2-羟基二苯基甲酮(4-(2-acryloxyethoxy-2-hydroxy benzophenone)或其组合。
本揭示内容提供一种制备前述任一实施方式的阻隔蓝光的隐形眼镜的方法，包括以下操作。混合第一亲水性单体与黄色染料，形成第一混合液。将第一混合液加热至25℃至80℃，加热时间为0.5小时至24小时，以形成阻隔蓝光成分。混合第二亲水性单体与第一有色染料，形成第二混合液。将第二混合液加热至25℃至80℃，加热时间为0.5小时至24小时，以形成第一有色染料成分。若上述加热温度高于80℃，可能生成过多的副产物，从而造成染料键结率降低，使镜片的蓝光阻隔率下降。固化含有阻隔蓝光成分、第一有色染料成分、至少一个第三亲水性单体、交联剂及起始剂的组成物，以形成隐形眼镜。在一些实施方式中，加热第一混合液或第二混合液的温度为25、35、45、55、65、75或80℃。在一些实施方式中，第一混合液或第二混合液的加热时间为0.5、1、5、10、15、20或24小时。在一些实施方式中，隐形眼镜为水胶隐形眼镜或硅水胶隐形眼镜。在一些实施方式中，组成物更包括含硅单体。在一些实施方式中，上述的固化操作，是将组成物注入塑胶公模与母模夹层之中，透过紫外光使组成物聚合，固化形成固体镜片。后续对固体镜片予以水化舒张，置于隐形眼镜包装液中再进行密封及高温灭菌处理，制得阻隔蓝光的隐形眼镜。
在一些实施方式中，方法更包括：在加热第一混合液前，将碱性物质及抑制剂加入第一混合液中，因此加热操作是对于含有第一亲水性单体、黄色染料、碱性物质及抑制剂的第一混合液进行加热。因此在加热后，第一亲水性单体与黄色染料会键结在一起，形成阻隔蓝光成分。根据上述操作，黄色染料是经过「合成法」预处理，以提高阻隔蓝光成分在组成物中的溶解度，从而提高隐形眼镜的显色性及阻隔蓝光率。在一些实施方式中，第一混合液的pH值为10～14。pH值例如为10、11、12、13或14。在一些实施方式中，抑制剂包括对苯二酚单甲醚(Mequinol,MeHQ)。在一些实施方式中，碱性物质包括氢氧化钠(NaOH)。在一些实施方式中，第一混合液不含水。在相同染料添加量的实验条件下，在无水环境下进行反应，能够使镜片的蓝光阻隔率较高；另一方面，在有水环境下进行反应，镜片的蓝光阻隔率较低。
以下为以亲水性单体甘油单甲基丙烯酸酯(GMMA)预处理活性黄 15(Reactive Yellow 15)，在碱性环境下形成阻隔蓝光成分的反应流程。首先活性黄15在氢氧化钠(NaOH)及抑制剂(MeHQ)存在下，会形成具有乙烯基的活性黄15，其会再与GMMA反应形成阻隔蓝光成分。相较未经预处理的活性黄15，经GMMA预处理的活性黄15在形成隐形眼镜的组成物中具有更佳的溶解度和相容性，从而能够提升其显色性和阻隔蓝光率。以下的反应流程可适用于具有乙烯基可聚合基团(ethylenically-base polymerizable group)、磺酸基(sulfonic group)、磺酰基(sulfonyl group)、磺酸盐基(sulfonate group)、酰胺基(amide group)或其组合的染料。
Figure PCTCN2022124788-appb-000001
在一些实施方式中，第一混合液不添加碱性物质及抑制剂，例如不添加氢氧化钠及MeHQ，因此在加热后的混合物中，第一亲水性单体与黄色染料不会形成键结，此混合物为阻隔蓝光成分。根据上述操作，黄色染料是经过「混合法」预处理，以提高后续阻隔蓝光成分在组成物中的溶解度， 从而提高隐形眼镜的显色性。值得注意的是，若在配制隐形眼镜组成物时，直接将未经处理的黄色染料、亲水性单体、交联剂及起始剂混合，黄色染料会有相容性不足的问题，会造成隐形眼镜的显色性不足，且抗蓝光效果不佳。在一些实施方式中，第一混合液不含水。
在一些实施方式中，方法更包括：在将第二混合液加热至25℃至80℃前，将碱性物质及抑制剂加入第二混合液中，因此加热操作是对于含有第二亲水性单体、第一有色染料、碱性物质及抑制剂的第二混合液进行加热。因此在加热后，第二亲水性单体与第一有色染料会键结在一起，形成第一有色染料成分。根据上述操作，第一有色染料是经过「合成法」预处理，以提高第一有色染料成分在组成物中的溶解度，从而提高隐形眼镜的显色性。在一些实施方式中，第二混合液的pH值为10～14。pH值例如为10、11、12、13或14。在一些实施方式中，抑制剂包括对苯二酚单甲醚。在一些实施方式中，碱性物质包括氢氧化钠。在一些实施方式中，第二混合液不含水。在相同染料添加量的实验条件下，在无水环境下进行反应，能够使镜片的蓝光阻隔率较高；另一方面，在有水环境下进行反应，镜片的蓝光阻隔率较低。
在一些实施方式中，第二混合液不添加碱性物质及抑制剂，例如不添加氢氧化钠及MeHQ，因此在加热后的混合物中，第二亲水性单体与第一有色染料成分不会形成键结，此混合物为第一有色染料成分。根据上述操作，第一有色染料是经过「混合法」预处理，以提高后续第一有色染料成分在组成物中的溶解度，从而提高隐形眼镜的显色性。值得注意的是，若在配制隐形眼镜组成物时，直接将未经处理的第一有色染料、亲水性单体、交联剂及起始剂混合，第一有色染料会有相容性不足的问题，会造成隐形眼镜的显色性不足。在一些实施方式中，第二混合液不含水。
在一些实施方式中，方法更包括混合第四亲水性单体与第二有色染料，形成第三混合液，将第三混合液加热至25℃至80℃，加热时间为0.5小时至24小时，以形成第二有色染料成分。将第二有色染料成分加入组成物中，再执行固化操作。若上述加热温度高于80℃，可能生成过多的副产物，从而造成染料键结率降低，使镜片的蓝光阻隔率下降。在一些实施方式中，方法更包括：在将第三混合液加热至25℃至80℃前，将碱性物质及抑制剂加入第三混合液中。在一些实施方式中，第三混合液不添加碱性物质及抑 制剂。第三混合液的实施方式可参照第二混合液的实施方式，不再赘述。
在一些实施方式中，含硅单体包括甲基丙烯酸3-[三(三甲基硅氧烷基)甲硅烷基]丙酯(TRIS,3-[Tris(trimethylsiloxy)silyl]propyl methacrylate)、(3-甲基丙烯酰氧基-2-羟基丙氧基)丙基双(三甲基硅氧基)甲基硅烷(SiGMA,(3-Methacryloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methylsilane)、3-甲基丙烯酰氧丙基三(三甲基硅氧基)硅烷(3-Methacryloxy propyltris(trimethylsiloxy)silane)、3-丙烯酰氧丙基三(三甲基硅氧基)硅烷(3-acryloxy propyltris(trimethylsiloxy)silane)、3-丙烯酰胺丙基三(三甲基硅氧基)硅烷(3-acrylamide propyltris(trimethylsiloxy)silane)、3-甲基丙烯酰胺丙基三(三甲基硅氧基)硅烷(3-Methacrylamide propyltris(trimethylsiloxy)silane)、3-乙烯基丙烯酰胺丙基三(三甲基硅氧基)硅烷(3-Vinylacrylamide propyltris(trimethylsiloxy)silane)、α-丙烯酰胺丙基-ω-丁基聚二甲基硅氧烷(α-acrylamidopropyl–ω-butylpolydimethylsiloxane)或其组合。
本揭示内容提供一种阻隔蓝光的隐形眼镜，其是由固化组成物而形成。组成物包括：阻隔蓝光成分、至少一个亲水性单体、交联剂及起始剂。阻隔蓝光成分是由甘油单甲基丙烯酸酯(GMMA)与黄色染料混合而成或反应而成。在一些实施方式中，隐形眼镜为水胶隐形眼镜或硅水胶隐形眼镜。在一些实施方式中，组成物更包括含硅单体。
在一些实施方式中，黄色染料是选自于由活性黄15、活性黄86及活性黄83所组成的群组。在一些实施方式中，以组成物为100wt％计，黄色染料为0.01wt％至2wt％。黄色染料例如为0.01、0.05、0.1、0.5、1、1.5或2wt％。当重量百分比落于上述范围内，可使隐形眼镜具有良好显色性及良好的阻隔蓝光率，且配戴者仍可以保持良好视觉感受。
在一些实施方式中，黄色染料与甘油单甲基丙烯酸酯的重量比为1：0.1至1：10。重量比例如为1：0.1、1：0.5、1：1、1：2、1：5或1：10。当重量分落于上述范围内，可使黄色染料在组成物中具有良好溶解度和良好相容性，从而使隐形眼镜具有良好显色性及阻隔蓝光率。
本揭示内容提供一种制备前述任一实施方式的阻隔蓝光的隐形眼镜的方法，包括以下操作。混合甘油单甲基丙烯酸酯与黄色染料，形成混合液。将混合液加热至25℃至80℃，加热时间为0.5小时至24小时，以形成阻隔蓝光成分。固化含有阻隔蓝光成分、至少一个亲水性单体、交联剂及起始 剂的组成物，以形成隐形眼镜。在一些实施方式中，加热混合液的温度为25、35、45、55、65、75或80℃。在一些实施方式中，混合液的加热时间为0.5、1、5、10、15、20或24小时。固化操作请参前述的实施方式，不再赘述。
在一些实施方式中，方法更包括：在将混合液加热至25℃至80℃前，将碱性物质及抑制剂加入混合液中。在一些实施方式中，混合液的pH值为10～14。pH值例如为10、11、12、13或14。在一些实施方式中，抑制剂包括对苯二酚单甲醚。在一些实施方式中，碱性物质包括氢氧化钠。在一些实施方式中，混合液不添加碱性物质及抑制剂。在一些实施方式中，混合液不含水。在相同染料添加量的实验条件下，在无水环境下进行反应，能够使镜片的蓝光阻隔率较高；另一方面，在有水环境下进行反应，镜片的蓝光阻隔率较低。在一些实施方式中，隐形眼镜为水胶隐形眼镜或硅水胶隐形眼镜。上述以GMMA处理黄色染料的实施方式的优点请参考前述关于第一混合液的实施方式，不再赘述。
下文将参照实验例，更具体地描述本揭示内容的特征。虽然描述了以下实验例，但是在不逾越本揭示内容范畴的情况下，可适当地改变所用材料、其量及比率、处理细节以及处理流程等等。因此，不应由下文所述的实验例对本揭示内容作出限制性地解释。
实验例：制造隐形眼镜
制造隐形眼镜包括以下操作：将阻隔蓝光隐形眼镜的水胶或硅水胶组成物，注入塑胶公模与母模夹层之中，透过紫外光使组成物聚合，固化形成固体镜片。取出固体镜片后予以水化舒张后，置于隐形眼镜包装液中再进行密封及高温灭菌处理(125℃、30分钟)，完成了阻隔蓝光多彩隐形眼镜的制造。
阻隔蓝光隐形眼镜的水胶组成物包含一种或一种以上亲水性单体、阻隔蓝光成分、交联剂及起始剂。阻隔蓝光隐形眼镜的硅水胶组成物包含一种或一种以上亲水性单体、阻隔蓝光单体、交联剂、起始剂及含硅单体。亲水性单体包括GMMA、HEMA或其组合。交联剂包括乙二醇二甲基丙烯酸酯。起始剂包括双(2,4,6-三甲基苯甲酰基)-苯基膦氧化物。水胶或硅水胶组成物可进一步包含一种有色成分或两种有色成分。阻隔蓝光成分包括经过「合成法」或「混合法」预处理的黄色染料。有色成分包括经「合成法」 或「混合法」预处理的绿色染料、蓝色染料、橘色染料、红色染料或黑色染料。「合成法」是在25℃至80℃下加热含有亲水性单体甘油单甲基丙烯酸酯(GMMA)、染料、碱性物质氢氧化钠(NaOH)及抑制剂MeHQ的混合液，加热时间为至少12小时。「合成法」是在25℃至80℃下加热含有亲水性单体甘油单甲基丙烯酸酯(GMMA)及染料的混合液，加热时间为至少12小时。在「合成法」或「混合法」中，染料和GMMA的重量比为1：10，MeHQ为约0.07wt％，氢氧化钠为约1wt％。
请参以下表1及表2，其分别列出实施例1至实施例25中各组成物的成分及配比，以及制备所得的镜片及其颜色和蓝光阻隔率。染料若经「混合法」预处理，标记为M1；染料若经「合成法」预处理，标记为M2。请参图1，图1是根据本揭示内容各种实施方式的制备方法得到的隐形眼镜。对应图1各镜片的穿透率光谱图请参图2至图7。图1包括暗红色镜片R1、棕红色镜片R2、橘红色镜片O1、橘色镜片O2、橘黄色镜片O3、琥珀色镜片Y1、暗黄色镜片Y2、黄色镜片Y3、黄绿色镜片G1、绿色镜片G2、亮绿色镜片G3、蓝色镜片B1、灰蓝色镜片B2、靛色镜片P1、紫色镜片P2及灰色镜片G。图1的镜片分别对应表1及表2中实施例8至实施例23的镜片。图2至图7分别示出对应上述镜片的光吸收率的曲线r1、r2、o1、o2、o3、y1、y2、y3、g1、g2、g3、b1、b2、p1、p2及g，以及未含染料的空白组镜片的光吸收率的曲线BLANK。由图1可知本揭示内容可形成具有多样色彩的多彩隐形眼镜，且皆具有鲜艳的色彩，可兼具有抗蓝光功效及配戴美观性。使用紫外光/可见光分光光谱仪测量隐形眼镜镜片的光穿透率，经由机台程序计算撷取380纳米至460纳米的平均蓝光穿透率(T％)，亦即平均有害蓝光穿透率，再用100％减去平均蓝光穿透率(T％)，即可得出表1及表2的蓝光阻隔率，亦即有害蓝光阻隔率。换言之，蓝光阻隔率％＝100％-蓝光穿透率(T％)。
表1
Figure PCTCN2022124788-appb-000002
表2
Figure PCTCN2022124788-appb-000003
如表1及表2所示，实施例1至实施例25的阻隔蓝光隐形眼镜的有害蓝光阻隔率介于5.57％至26.27％。因此，本揭示内容的阻隔蓝光隐形眼镜实质上可达到5％至30％的有害蓝光阻隔率。实施例1至实施例24可制得水胶隐形眼镜，而实施例25则可制得硅水胶隐形眼镜。实施例25添加染料活性黄15约0.100wt％且采用合成法进行预处理，可使镜片具有蓝光阻隔率26.27％，由此可知，本揭示内容的预处理方法在硅水胶组合物系统中可达更好的蓝光阻隔率效果。
有害蓝光的阻隔率主要受黄色染料浓度和预处理的影响，其他非黄色染料的影响较小。以下表3列出仅使用活性黄15进行制备的实施例。
表3
Figure PCTCN2022124788-appb-000004
比较实施例2和实施例7，两者的镜片呈色都为黄色，活性黄15的含量皆约0.150wt％。实施例2经由混合法M1预处理活性黄15，使镜片的蓝光阻隔率为13.05％，然而，实施例7经由合成法M2预处理活性黄15，可使镜片的蓝光阻隔率大幅提升至25.29％，高出了12.24％。换言之，实施例7的镜片蓝光阻隔率约为实施例2的镜片蓝光阻隔率的两倍。由此可知，在相同黄色染料比例下，通过合成法对染料进行预处理，可以大大提升镜片对于有害蓝光的阻隔效果。
比较实施例2和实施例8，实施例8仅添加0.085wt％的活性黄15，并以合成法M2进行预处理，镜片的蓝光阻隔率可达14.66％，实施例2添加0.150wt％的活性黄15，并以混合法M1进行预处理，镜片的蓝光阻隔率为13.05％。由此可知，以合成法预处理染料，可在添加少量染料的情况下，使镜片依然具有良好的蓝光阻隔率。比较实施例8与实施例2，实施例8的添加量可减少0.065wt％，并且在水化过程，实施例8所做出的产品亦可降低染料水洗溶出量，减少工艺废水。比较实施例6和实施例7，若需使镜片达到蓝光阻隔率25％，实施例6需使用0.301wt％的活性黄15，而实施例7则仅使用0.150wt％的活性黄15，添加量可减少0.151wt％。由此可知，通过合成法对染料进行预处理，可以大大提升镜片对于有害蓝光的阻隔效果。
综上所述，本揭示内容提供阻隔蓝光的隐形眼镜及其制备方法，通过以「合成法」或「混合法」以亲水性单体对各色的染料进行预处理，再将其与其他制备隐形眼镜的材料(例如其他亲水性单体、交联剂、起始剂或含硅单体)混合再固化形成镜片，可制得显色性良好且具有鲜艳色彩的隐形眼镜，隐形眼镜同时具有良好的抗蓝光效果。相较于「混合法」，「合成法」 可更有效提升染料在组合物中的溶解度和相容性，且可进一步减少工艺废水。并且，本揭示内容的方法可通过使用多种染料的组合提升多彩镜片制造的可行性。
尽管已经参考某些实施方式相当详细地描述了本揭示内容，但是亦可能有其他实施方式。因此，所附申请专利范围的精神和范围不应限于此处包含的实施方式的描述。
对于所属技术领域具有通常知识者来说，显而易见的是，在不脱离本揭示内容的范围或精神的情况下，可以对本揭示内容的结构进行各种修改和变化。鉴于前述内容，本揭示内容意图涵盖落入所附申请专利范围内的本揭示内容的修改和变化。

Claims (20)

  1. 一种阻隔蓝光的隐形眼镜，其特征在于，该隐形眼镜是由固化组成物而形成，该组成物包括：
    阻隔蓝光成分，该阻隔蓝光成分是由第一亲水性单体与黄色染料混合而成或反应而成；
    第一有色染料成分，该第一有色染料成分是由第二亲水性单体与第一有色染料混合而成或反应而成，其中该第一有色染料包括绿色染料、青色染料、蓝色染料、橘色染料、红色染料、黑色染料或其组合；
    至少一个第三亲水性单体；
    交联剂；以及
    起始剂。
  2. 根据权利要求1所述的隐形眼镜，其特征在于，该第一亲水性单体、该第二亲水性单体及该第三亲水性单体是独立选自于由N-乙烯吡咯烷酮、2-羟基乙基甲基丙烯酸酯、甲基丙烯酸缩水甘油酯、甘油单甲基丙烯酸酯、甲基丙烯酸、丙烯酸、N,N-二甲基丙烯酰胺、N,N-二乙基丙烯酰胺、N-乙基-N-甲基乙酰胺、2-甲基丙烯酰氧乙基磷酰胆碱及甲基丙烯酸2-羟基丁酯所组成的群组。
  3. 根据权利要求1所述的隐形眼镜，其特征在于，组成物更包括第二有色染料成分，该第二有色染料成分是由第四亲水性单体与第二有色染料混合而成或反应而成，其中该第二有色染料包括绿色染料、青色染料、蓝色染料、橘色染料、红色染料、黑色染料或其组合。
  4. 根据权利要求3所述的隐形眼镜，其特征在于，该第四亲水性单体是选自于由N-乙烯吡咯烷酮、2-羟基乙基甲基丙烯酸酯、甲基丙烯酸缩水甘油酯、甘油单甲基丙烯酸酯、甲基丙烯酸、丙烯酸、N,N-二甲基丙烯酰胺、N,N-二乙基丙烯酰胺、N-乙基-N-甲基乙酰胺、2-甲基丙烯酰氧乙基磷酰胆碱及甲基丙烯酸2-羟基丁酯所组成的群组。
  5. 根据权利要求1所述的隐形眼镜，其特征在于，以该组成物为100wt％ 计，该黄色染料为0.01wt％至2wt％，该第一有色染料为0.01wt％至2wt％。
  6. 根据权利要求1所述的隐形眼镜，其特征在于，该黄色染料为0.01重量分至2重量分，该第一有色染料为大于0重量分且小于等于2重量分。
  7. 根据权利要求1所述的隐形眼镜，其特征在于，该黄色染料与该第一亲水性单体的重量比为1：0.1至1：10。
  8. 根据权利要求1所述的隐形眼镜，其特征在于，该第一有色染料与该第二亲水性单体的重量比为1：0.1至1：10。
  9. 根据权利要求1所述的隐形眼镜，其特征在于，该黄色染料是选自于由活性黄15、活性黄86及活性黄83所组成的群组。
  10. 根据权利要求1所述的隐形眼镜，其特征在于，该第一有色染料具有乙烯基可聚合基团、磺酸基、磺酰基、磺酸盐基、酰胺基或其组合。
  11. 根据权利要求1所述的隐形眼镜，其特征在于，该第一有色染料是选自于由活性蓝4、活性蓝19、活性蓝21、活性蓝69、活性蓝163、活性蓝246、活性蓝247、活性红11、活性红180、活性黑、活性橙78及颜料绿所组成的群组。
  12. 一种制备如权利要求1所述的阻隔蓝光的隐形眼镜的方法，其特征在于，包括：
    混合该第一亲水性单体与该黄色染料，形成第一混合液；
    将该第一混合液加热至25℃至80℃，加热时间为0.5小时至24小时，以形成该阻隔蓝光成分；
    混合该第二亲水性单体与该第一有色染料，形成第二混合液；
    将该第二混合液加热至25℃至80℃，加热时间为0.5小时至24小时，以形成该第一有色染料成分；以及
    固化该阻隔蓝光成分、该第一有色染料成分、至少一个第三亲水性单 体、交联剂及起始剂。
  13. 根据权利要求12所述的方法，其特征在于，更包括：在将该第一混合液加热至25℃至80℃前，将碱性物质及抑制剂加入该第一混合液中。
  14. 根据权利要求12所述的方法，其特征在于，更包括：在将该第二混合液加热至25℃至80℃前，将碱性物质及抑制剂加入该第二混合液中。
  15. 一种阻隔蓝光的隐形眼镜，其特征在于，该隐形眼镜是由固化组成物而形成，该组成物包括：
    阻隔蓝光成分，该阻隔蓝光成分是由甘油单甲基丙烯酸酯与黄色染料混合而成或反应而成；
    至少一个亲水性单体；
    交联剂；以及
    起始剂。
  16. 根据权利要求15所述的隐形眼镜，其特征在于，以该组成物为100wt％计，该黄色染料为0.01wt％至2wt％。
  17. 根据权利要求15所述的隐形眼镜，其特征在于，该黄色染料是选自于由活性黄15、活性黄86及活性黄83所组成的群组。
  18. 根据权利要求15所述的隐形眼镜，其特征在于，该黄色染料与该甘油单甲基丙烯酸酯的重量比为1：0.1至1：10。
  19. 一种制备如权利要求15所述的阻隔蓝光的隐形眼镜的方法，其特征在于，包括：
    混合该甘油单甲基丙烯酸酯与该黄色染料，形成混合液；
    将该混合液加热至25℃至80℃，加热时间为0.5小时至24小时，以形成该阻隔蓝光成分；以及
    固化该阻隔蓝光成分、至少一个亲水性单体、交联剂及起始剂。
  20. 根据权利要求19所述的方法，其特征在于，更包括：在将该混合液加热至25℃至80℃前，将碱性物质及抑制剂加入该混合液中。
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