WO2024047195A1 - Composition comprising coral mucus and use thereof - Google Patents

Composition comprising coral mucus and use thereof Download PDF

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Publication number
WO2024047195A1
WO2024047195A1 PCT/EP2023/073961 EP2023073961W WO2024047195A1 WO 2024047195 A1 WO2024047195 A1 WO 2024047195A1 EP 2023073961 W EP2023073961 W EP 2023073961W WO 2024047195 A1 WO2024047195 A1 WO 2024047195A1
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WO
WIPO (PCT)
Prior art keywords
mucus
coral
composition
skin
composition according
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PCT/EP2023/073961
Other languages
French (fr)
Inventor
Inès GALTIER D’AURIAC
Original Assignee
Galtier D’Auriac Ines
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Publication date
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Publication of WO2024047195A1 publication Critical patent/WO2024047195A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings

Definitions

  • composition comprising coral mucus, and its use
  • the present invention relates to the field of natural products for the cosmetic and well-being industry sector.
  • the field of the invention relates more particularly to the use of coral mucus in these areas and more specifically for the formulation of therapeutic or cosmetic compositions or natural food supplements.
  • Corals are organisms whose cellular and molecular physiology is still relatively little known and which live individually for up to several decades. They survive over long periods, although constantly exposed to bacterial, viral, fungal attacks, but also to environmental hazards such as climate or pollution; many opportunistic or specialized parasitic organisms or predators also constitute a nuisance. The resistance of corals to all of these harmful effects therefore foreshadows a potential source of new natural molecules with interesting effects in the field of cosmetics, dermatology, well-being or pharmaceuticals.
  • Mucus is an often viscous substance created by living organisms. This surface layer that covers the skin of many marine animals is a protective barrier against external threats.
  • Coral produces mucus in particular. It is the ectoderm of corals that secretes mucus. Mucus is defined as a mixture of proteins and carbohydrates. This constitutes a mesh very thin and can be used in the same way as a "fishing net". It will, in fact, be able to trap food particles and zooplankton elements. Once stuck in this net, these elements will be brought to the mouth by ciliary movements or by the tentacles. Corals are currently closely monitored in view of climate change which is leading to their bleaching and the reduction of their population.
  • the publication XP35127195 “Antibacterial activity of pseudoalterominas in the Coral Holobiont” focuses on the antibacterial effect of a family of Pseudoalterominas bacteria identified in the mucus of corals Platygyra sp, Porites sp, Stylophora sp. And Pocillopora sp and concludes that this family of bacteria should play a role in protecting corals against gram-positive bacteria pathogenic to corals.
  • the aim of the present invention is to propose a composition comprising coral mucus and its use.
  • the invention relates, according to one embodiment, to a composition
  • a composition comprising, advantageously all or part, mucus from at least one coral, and advantageously an excipient or vehicle suitable for subcutaneous application or for oral administration or topical administration.
  • the invention relates to a food supplement comprising mucus from at least one coral or comprising the composition comprising mucus from at least one coral.
  • the invention relates to a cosmetic composition comprising mucus from at least one coral.
  • the invention relates to the cosmetic use of coral mucus, advantageously all or part of the coral mucus.
  • the invention relates to the use of the cosmetic composition or the food supplement.
  • the invention relates to a composition comprising mucus from at least one coral intended for a therapeutic application. According to another aspect, the invention relates to a process for obtaining mucus from at least one coral.
  • the composition comprises mucus from at least one coral.
  • the at least one coral is chosen from soft mucus-producing corals or hard mucus-producing corals.
  • the mucus is in the viscous state or in the dry state.
  • the invention relates to a cosmetic and non-therapeutic composition comprising mucus from at least one coral.
  • the cosmetic and non-therapeutic composition is configured to be in the form of a shampoo, a mask, a soap, a gel, a cream, a lotion, a balm, spray, toothpaste.
  • the cosmetic use of coral mucus is suitable for topical application to the skin, mucous membranes or integuments.
  • the cosmetic use of coral mucus is suitable in the form of a shampoo, for example liquid or solid, of a soap, of a gel, a cream, a lotion, a balm, a spray, a mask, a toothpaste, for example with a soft or hard paste.
  • the invention relates to a personal hygiene product or a cosmetic care product comprising coral mucus, advantageously all or part of the coral mucus.
  • the invention relates to a shampoo, a soap, a gel, a cream, a lotion, a balm, a spray, a mask, a toothpaste comprising coral mucus, advantageously all or part of the coral mucus.
  • the invention relates to the use of the cosmetic and non-therapeutic composition for:
  • thermoprotective effect - fight against color changes or irregularities in pigmentation, abnormal and/or excessive keratinization of the skin, - a thermoprotective effect
  • the invention relates to the use by topical application to the skin, mucous membranes or appendages of the cosmetic and non-therapeutic composition.
  • the invention relates to a food supplement comprising the composition.
  • the food supplement is configured to be in the form of a dose, a capsule, a lozenge, a tablet, a pill, a sachet of powder, an ampoule of liquid , bottle fitted with a dropper.
  • the invention relates to the use of the food supplement for
  • the invention relates to the use of the food supplement by oral application of the food supplement.
  • the invention relates to a composition intended for therapeutic application for:
  • the invention relates to a method for obtaining mucus from at least one coral comprising a step of recovering the mucus by suction or by gravity.
  • a parameter “substantially equal/greater/less than” or “of the order of” a given value is meant that this parameter is equal/greater/less than the given value, to within plus or minus 10%, or even to plus or minus 5% of this value.
  • “Mucus” means a gelatinous, aqueous or viscous liquid.
  • Coral mucus is a complex mixture of organic matter composed mainly of carbohydrates (mainly polysaccharides) and proteins, but also of lipids which is produced by the mucocytes of the coral epidermal layer of the ectoderm on the surface of the coral.
  • coral we mean a living organism of the class Anthozoa (within the phylum Cnidaria), characterized by a calcareous (hard) or proteinaceous (soft) exoskeleton.
  • Anthozoa within the phylum Cnidaria
  • calcareous hard
  • proteinaceous soft
  • “Coral mucus” or “mucus from at least one coral” means mucus or a mixture of mucus.
  • the coral mucus according to the invention is either in the raw state, that is to say unmodified following its collection, with the exception of a sterilization treatment, in this case the mucus is in a more or less liquid state commonly called viscous state, either in the dried or freeze-dried state, that is to say unmodified except for its dehydration, the mucus is then preferentially in a powder state.
  • Coral mucus is also understood to be in a solid form below its solidification temperature. For example, the invention applies to frozen coral mucus.
  • anti-aging means an effect intended to combat superficial aging of the skin such as, for example, flaccidity, sagging, wrinkles and fine lines, dryness, dehydration, loss of elasticity of the skin. skin, loss of shine, luminosity and radiance of the skin, dilation of pores, thickening of the superficial layer, changes in color or irregularities in pigmentation, abnormal and/or excessive keratinization of the skin .
  • moistureturizer we mean a product that hydrates the skin and the surface layer of the epidermis and prevents its dehydration by reconstituting the hydrolipidic film, the natural protection of the skin and all the properties that result from it.
  • UV protection or “photoprotection” we mean the various means capable of opposing skin damage induced by solar radiation.
  • solar radiation we mean the radiation emitted by the sun and arriving at the surface of the Earth, in particular UV-A and UV-B rays but also infrared rays causing heating of the skin.
  • probiotic effect we mean the protection of the skin or digestive microbiota (or flora) from external aggressions.
  • probiotics which are living microscopic organisms (yeasts, viruses, bacteria, etc.), produce toxic substances to destroy them.
  • thermoprotective effect for hair cosmetics, we mean protection against heat caused for example by a hairdryer or curling iron.
  • cosmetically acceptable or “suitable for “cosmetic use” is meant compatible with the skin and/or mucous membranes and/or skin appendages, which has a pleasant color, odor and feel and which does not generate unacceptable discomfort (tingling, tightness, redness), likely to dissuade the consumer from using this composition.
  • Food supplement means a product as defined in Directive 2002/46/EC of the European Parliament and of the Council, dated June 10, 2002, relating to the approximation of the laws of the Member States relating to food supplements.
  • the term “food supplement” means a food whose purpose is to supplement the normal diet and which constitutes a concentrated source of nutrients or other substances having a nutritional or physiological effect alone or in combination.
  • the invention relates to a composition comprising mucus from at least one coral.
  • Mucus is mucus from a single coral or a mixture of mucus from several corals.
  • the mucus is either in a viscous state or in a dry state, for example in powder form.
  • the mucus is advantageously raw mucus, that is to say unmodified still called native, with the exception of a sterilization and/or freeze-drying or dehydration treatment.
  • mucus is understood as all or part of the mucus.
  • the mucus having been enriched or not.
  • the mucus includes adapted concentrations of the different components.
  • the at least one coral is chosen from the hard corals of the Acropora family Acropora yongei, Porites, Hermatypic, Porites astreoides, Diploria strigosa, Montastrea annularis, Colpophyllia natans, Acropora palmata, Lobophyllia hemprichii, Fungia scutaria, Fungia repanda, Acropora danai, Pocillopora eydouxi, Pocillopora meandrian, Fungia fungites, Fungia repanda, Diaseris distorta, Fungia scutaria, Cycloseris costulata, Cycloseris doederleini, Cycloseris marginata, Fungia actiniformis, Fungia danai, Fungia echinata, Fungia fungites, Fungia gran
  • the at least one coral is chosen from soft corals chosen from Sarcophyton sp., Lemnalia sp., Cespitularia sp., Rumphella aggregata, coelenterates from the Red Sea, Lobophyton sp, Rhytisma fulvum fulvum and Xenia sp.
  • the composition consists solely of mucus from at least one coral.
  • the composition comprises at least one excipient or a vehicle suitable for subcutaneous application.
  • the composition comprises at least one excipient or vehicle suitable for topical application. According to one embodiment, the composition comprises at least one excipient or vehicle suitable for oral administration.
  • the composition comprises at least one cosmetically acceptable excipient or vehicle.
  • the composition is a cosmetic, non-therapeutic composition, that is to say that the cosmetic composition is a composition suitable for cosmetic application.
  • the cosmetic composition is advantageously intended for topical application.
  • the cosmetic composition preferably has a form suitable for topical or subcutaneous application.
  • the cosmetic composition is intended and advantageously adapted for application to the skin including the lips, hair, eyelashes, eyebrows and/or nails.
  • the cosmetic composition is for example in the form of a shampoo, a soap, a gel, a cream, a lotion, a balm, a spray.
  • the cosmetic composition is advantageously intended to be used for hydrating the skin, mucous membranes or appendages, combating skin aging, reducing wrinkles and fine lines, combating the loss of elasticity of the skin, combating loss of shine, luminosity or radiance of the skin, reduce the dilation of pores, reduce thickening of the superficial layer of the skin, combat color changes or irregularities in pigmentation, abnormal keratinization and/ or excess of the skin, protection of the skin barrier, improvement, maintenance and protection of the skin microbiota, thermoprotection of the hair, promote cell renewal, particularly in the skin, improve the firmness of the skin.
  • the composition comprises at least one excipient or vehicle configured to be used as a food supplement.
  • the invention relates to a food supplement comprising mucus from at least one coral or a composition comprising mucus from at least one coral as described above.
  • the food supplement is advantageously intended for oral administration.
  • the food supplement preferably presents a form suitable for oral administration such as for example a liquid or pseudo-liquid such as viscous, that is to say in the form of syrup, gel, spray, ampoule, capsule, bottle fitted with a dropper or such as for example in the form of a solid dose such as a capsule, a capsule, a lozenge, a tablet, a pill, a cachet, a sachet of powder.
  • a form suitable for oral administration such as for example a liquid or pseudo-liquid such as viscous, that is to say in the form of syrup, gel, spray, ampoule, capsule, bottle fitted with a dropper or such as for example in the form of a solid dose such as a capsule, a capsule, a lozenge, a tablet, a pill, a cachet, a sachet of powder.
  • Other similar forms of liquid or powder preparations intended to be taken in measured units may be used.
  • the food supplement is intended to be used in dose form.
  • the food supplement is intended to be used daily in the form of a dose, 1 to 3 times per day, for example in the morning, midday and/or evening.
  • the food supplement is advantageously intended to be used for hydration of the skin, mucous membranes or appendages, combating skin aging, reducing wrinkles and fine lines, combating the loss of elasticity of the skin, combating loss of shine, luminosity or radiance of the skin, reduce the dilation of pores, reduce the thickening of the superficial layer of the skin, combat color changes or irregularities in pigmentation, abnormal and/or excessive keratinization of the skin , protection of the skin barrier, improvement of firmness, improvement, maintenance and protection of the digestive or skin microbiota, improve intestinal and digestive comfort, promote weight loss or reduce soreness, burning, heaviness , constipation or bloating.
  • the composition comprises at least one pharmaceutically acceptable excipient or vehicle.
  • the composition is a therapeutic composition, that is to say the composition is a composition suitable for therapeutic application.
  • the invention relates to a composition comprising mucus from at least one coral intended for a therapeutic application.
  • the therapeutic composition is advantageously intended for topical or subcutaneous application or by oral administration.
  • the therapeutic composition preferably has a form suitable for topical or subcutaneous or oral application.
  • the therapeutic composition is intended and advantageously adapted for application to the skin including the lips, hair, eyelashes, eyebrows and/or nails.
  • the therapeutic composition is for example in the form of a shampoo, a soap, a gel, a cream, a lotion, a balm, a spray.
  • the therapeutic composition is also suitable for oral administration by being for example in the form of a syrup, gel, spray, ampoule, capsule, bottle fitted with a dropper or such as for example in the form of solid dose such as a capsule, a capsule, a lozenge, a tablet, a pill, a cachet, a sachet of powder.
  • the cosmetic composition is also suitable for subcutaneous administration, for example by injection.
  • the composition is advantageously intended to be used for a therapeutic application for an anti-inflammatory effect, an antibacterial effect, an antiviral effect, treatment of acne, treatment of eczema, skin photoprotection, an antioxidant effect, cellular repair.
  • the quantity of mucus in cosmetic applications is between 0.5% and 50% by weight of the total weight of the final composition.
  • the quantity of mucus in therapeutic applications is between 50.5% and 100% by weight of the total weight of the final composition.
  • the quantity of mucus in food supplement applications is between 0.5% and 100% by weight of the total weight of the final composition.
  • the invention relates to a process for obtaining mucus from at least one coral.
  • the method according to the invention comprises a step of recovering the mucus advantageously without damaging the coral.
  • the coral is not destroyed, is not cut.
  • the coral remains intact.
  • the method according to the invention is non-invasive.
  • the recovery step is carried out by suction of the mucus or by gravity. More precisely, the coral is turned over to collect the mucus by gravity or the mucus can also be collected with a syringe by aspiration.
  • the process comprises a step preliminary to the recovery step which is a step of removing the coral from the water.
  • the process comprises a step subsequent to the step of removing the coral from the water which is a step of eliminating excess water, more precisely the coral is sponged.
  • the method comprises a step of stimulating the production of mucus before the recovery step and preferably after the step of removing the coral from the water and preferentially after the step of eliminating the excess water.
  • the step of stimulating mucus production is carried out by contact with air and/or by agitation with a glass rod.
  • the method according to the invention comprises a step of sterilizing the mucus.
  • the sterilization step is carried out by exposing the mucus for a predefined time to UV radiation, for example a UV lamp.
  • UV radiation for example a UV lamp.
  • This step makes it possible to remove microorganisms, preferably viruses and parasites, from the mucus without degrading the primary structure of the mucus.
  • sterilization is carried out by exposing the mucus under a UV lamp for a predefined time, for example of the order of two hours in an Eppendorf® type tube, or by irradiation with gamma photons for a predefined time.
  • the tube is then closed and placed in a paper cryobox.
  • the entire box is then treated with gamma photons at a dose of 25 to 50 kGy using a standard commercial process.
  • the method according to the invention comprises a step of antibiotic treatment of the mucus.
  • the mucus is subjected to at least one antibiotic or several antibiotics selected to destroy certain bacteria and preserve others. This step is particularly useful when used as a probiotic.
  • the cosmetic composition and/or the food supplement are formulated from natural ingredients.
  • the invention relates to a process comprising the cosmetic application of coral mucus, advantageously all or part of the coral mucus.
  • the cosmetic application comprises a topical application.
  • the cosmetic application includes application to the skin including the lips, hair, eyelashes, eyebrows and/or nails.
  • the method comprises the cosmetic application of a composition comprising coral mucus.
  • Example 1 cosmetic composition for a cream, lotion or gel:
  • Example 3 food supplement in the form of a daily dose:
  • the coral chosen is Acropora yongei.
  • the coral is out of the aquarium.
  • the coral is advantageously turned over and preferably exposed to the air for a predefined time, for example 10 seconds advantageously to reduce the stress of the corals.
  • the mucus is then collected directly into a glass or Falcon® tube.
  • the coral chosen is Acropora yongei.
  • the coral is out of the aquarium.
  • the coral is advantageously turned over and preferably exposed to the air and mechanically stimulated for a predefined time, for example 5 seconds advantageously to reduce stress on the corals.
  • Mechanical stimulation is carried out by a rod, preferably made of glass, which is slid along the coral. The mucus is then collected directly into a glass or Falcon® tube.
  • the coral chosen is Acropora yongei.
  • the coral is maintained in the aquarium.
  • the coral is mechanically stimulated for a predefined time, for example 5 seconds advantageously to reduce stress on the corals.
  • Mechanical stimulation is carried out by a rod, preferably made of glass, which is slid along the coral or by jets of water.
  • the mucus is then collected by a pipette.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention relates to a composition comprising mucus from at least one coral and to the use thereof in a cosmetic composition or dietary supplement, to a composition comprising coral mucus for therapeutic applications, and to a method for obtaining mucus from at least one coral, which method comprises a step of collecting the mucus by gravity and suction collection methods. The present invention relates to the field of natural products for the cosmetic industry sector, the dietary supplement sector or the pharmaceutical sector. More specifically, the invention relates to the use of coral mucus in these sectors and more specifically to the formulation of cosmetic compositions or natural dietary supplements.

Description

« Composition comprenant du mucus de corail, et son utilisation » “Composition comprising coral mucus, and its use”
DOMAINE TECHNIQUE TECHNICAL AREA
La présente invention concerne le domaine des produits naturels pour le secteur de l’industrie cosmétique, du bien-être. The present invention relates to the field of natural products for the cosmetic and well-being industry sector.
Le domaine de l’invention concerne plus particulièrement l’utilisation de mucus de corail dans ces domaines-là et plus spécifiquement pour la formulation de compositions thérapeutiques ou cosmétiques ou de compléments alimentaires naturels. The field of the invention relates more particularly to the use of coral mucus in these areas and more specifically for the formulation of therapeutic or cosmetic compositions or natural food supplements.
ETAT DE LA TECHNIQUE STATE OF THE ART
Les coraux sont des organismes dont la physiologie cellulaire et moléculaire est encore assez peu connue et qui vivent individuellement jusqu'à plusieurs décennies. Ils survivent sur de longues périodes, bien que constamment exposés aux attaques bactériennes, virales, fongiques, mais également aux aléas environnementaux de types climatiques ou liés à la pollution ; de nombreux organismes parasites ou prédateurs opportunistes ou spécialisés constituent également une nuisance. La résistance des coraux à l’encontre de l’ensemble de ces effets nocifs préfigure donc une source potentielle de nouvelles molécules naturelles ayant des effets intéressants dans le domaine de la cosmétique, de la dermatologie, du bien-être ou de la pharmaceutique. Corals are organisms whose cellular and molecular physiology is still relatively little known and which live individually for up to several decades. They survive over long periods, although constantly exposed to bacterial, viral, fungal attacks, but also to environmental hazards such as climate or pollution; many opportunistic or specialized parasitic organisms or predators also constitute a nuisance. The resistance of corals to all of these harmful effects therefore foreshadows a potential source of new natural molecules with interesting effects in the field of cosmetics, dermatology, well-being or pharmaceuticals.
Le mucus est une substance souvent visqueuse créée par les organismes vivants. Cette couche superficielle qui recouvre la peau de nombreux animaux marins est une barrière protectrice contre les menaces extérieures. Mucus is an often viscous substance created by living organisms. This surface layer that covers the skin of many marine animals is a protective barrier against external threats.
Le corail produit notamment du mucus. C’est l’ectoderme des coraux qui sécrète le mucus. Le mucus est défini comme un mélange de protéines et de glucides. Celui-ci constitue un maillage très fin et va pouvoir être utilisé de la même manière qu’un "filet de pêche". Il va, en effet, pouvoir piéger des particules alimentaires et des éléments du zooplancton. Une fois englués dans ce filet, ces éléments vont être apportés à la bouche par des mouvements ciliaires ou par les tentacules. Les coraux sont actuellement très surveillés au regard des changements climatiques qui entrainement leur blanchiment et la réduction de leur population. Coral produces mucus in particular. It is the ectoderm of corals that secretes mucus. Mucus is defined as a mixture of proteins and carbohydrates. This constitutes a mesh very thin and can be used in the same way as a "fishing net". It will, in fact, be able to trap food particles and zooplankton elements. Once stuck in this net, these elements will be brought to the mouth by ciliary movements or by the tentacles. Corals are currently closely monitored in view of climate change which is leading to their bleaching and the reduction of their population.
On connait le document KR 20140066521 qui concerne les poissons et l’utilisation de leur mucus. Les poissons sont des animaux vertébrés aquatiques qui se distinguent fortement des coraux qui sont des animaux invertébrés. We know the document KR 20140066521 which concerns fish and the use of their mucus. Fish are aquatic vertebrate animals that are strongly distinguished from corals which are invertebrate animals.
La publication XP35127195 « Antibacterial activity of pseudoalterominas in the Coral Holobiont » s’intéresse à l’effet antibactérien d’une famille de bactéries Pseudoalterominas identifiées dans le mucus des coraux Platygyra sp, Porites sp, Stylophora sp. Et Pocillopora sp et conclut que cette famille de bactéries devrait jouer un rôle de protection des coraux contre des bactéries gram-positive pathogènes pour les coraux. The publication XP35127195 “Antibacterial activity of pseudoalterominas in the Coral Holobiont” focuses on the antibacterial effect of a family of Pseudoalterominas bacteria identified in the mucus of corals Platygyra sp, Porites sp, Stylophora sp. And Pocillopora sp and concludes that this family of bacteria should play a role in protecting corals against gram-positive bacteria pathogenic to corals.
La publication XP93038660 « Coral Mucus is a hot spot for viral infection » concerne l’évaluation de la diffusion de virus pathogène chez les coraux et conclut que le mucus de corail représente un habitat hautement favorable pour la prolifération virale. The publication XP93038660 “Coral Mucus is a hot spot for viral infection” concerns the evaluation of the diffusion of pathogenic viruses in corals and concludes that coral mucus represents a highly favorable habitat for viral proliferation.
Le document US2018/318205 décrit quant à lui l’utilisation d’algues rouges dans des cosmétiques. Les algues rouges malgré leur dénomination anglaise « slender beaded coral weed » sont des végétaux et ne sont pas des coraux. Document US2018/318205 describes the use of red algae in cosmetics. Red algae, despite their English name “slender beaded coral weed”, are plants and are not corals.
La présente invention a pour but de proposer une composition comprenant du mucus des coraux et son utilisation. The aim of the present invention is to propose a composition comprising coral mucus and its use.
Les autres objets, caractéristiques et avantages de la présente invention apparaîtront à l'examen de la description suivante et des dessins d'accompagnement. Il est entendu que d'autres avantages peuvent être incorporés. The other objects, characteristics and advantages of the present invention will appear on examination of the following description and the accompanying drawings. It is understood that other benefits may be incorporated.
RESUME SUMMARY
Pour atteindre cet objectif, l’invention concerne selon un mode de réalisation, une composition comprenant, avantageusement tout ou partie, du mucus issu d’au moins un corail, et avantageusement un excipient ou véhicule adapté pour une application sous-cutanée ou pour une administration orale ou administration topique. To achieve this objective, the invention relates, according to one embodiment, to a composition comprising, advantageously all or part, mucus from at least one coral, and advantageously an excipient or vehicle suitable for subcutaneous application or for oral administration or topical administration.
Selon un autre aspect, l’invention concerne un complément alimentaire comprenant du mucus issu d’au moins un corail ou comprenant la composition comprenant du mucus issu d’au moins un corail. According to another aspect, the invention relates to a food supplement comprising mucus from at least one coral or comprising the composition comprising mucus from at least one coral.
Selon un autre aspect, l’invention concerne une composition cosmétique comprenant du mucus issu d’au moins un corail. According to another aspect, the invention relates to a cosmetic composition comprising mucus from at least one coral.
Selon un autre aspect, l’invention concerne l’utilisation cosmétique du mucus de corail, avantageusement de tout ou partie du mucus corail. According to another aspect, the invention relates to the cosmetic use of coral mucus, advantageously all or part of the coral mucus.
Selon un autre aspect, l’invention concerne l’utilisation de la composition cosmétique ou du complément alimentaire. According to another aspect, the invention relates to the use of the cosmetic composition or the food supplement.
Selon un autre aspect, l’invention concerne une composition comprenant du mucus issu d’au moins un corail destiné à une application thérapeutique. Selon un autre aspect, l’invention concerne un procédé d’obtention de mucus issu d’au moins un corail. According to another aspect, the invention relates to a composition comprising mucus from at least one coral intended for a therapeutic application. According to another aspect, the invention relates to a process for obtaining mucus from at least one coral.
DESCRIPTION DÉTAILLÉE DETAILED DESCRIPTION
Avant d’entamer une revue détaillée de modes de réalisation de l’invention, sont énoncées ci- après des caractéristiques optionnelles qui peuvent éventuellement être utilisées en association ou alternativement : Before beginning a detailed review of embodiments of the invention, the following are set out as optional characteristics which may possibly be used in combination or alternatively:
Selon un exemple, la composition comprend du mucus issu d’au moins un corail. According to one example, the composition comprises mucus from at least one coral.
Selon un exemple, le au moins un corail est choisi parmi les coraux producteurs de mucus mous ou les coraux producteurs de mucus durs. According to one example, the at least one coral is chosen from soft mucus-producing corals or hard mucus-producing corals.
Selon un exemple, le mucus, avantageusement tout ou partie, est à l’état visqueux ou à l’état sec. Selon un aspect, l’invention concerne une composition cosmétique et non thérapeutique comprenant du mucus issu d’au moins un corail. According to one example, the mucus, advantageously all or part, is in the viscous state or in the dry state. According to one aspect, the invention relates to a cosmetic and non-therapeutic composition comprising mucus from at least one coral.
Selon un exemple, la composition cosmétique et non thérapeutique est configurée pour être sous la forme d’un shampoing, d’un masque, d’un savon, d’un gel, d’une crème, d’une lotion, d’un baume, d’un spray, d’un dentifrice. According to one example, the cosmetic and non-therapeutic composition is configured to be in the form of a shampoo, a mask, a soap, a gel, a cream, a lotion, a balm, spray, toothpaste.
Selon un exemple, l’utilisation cosmétique du mucus de corail, avantageusement de tout ou partie du mucus corail, sous forme, est adaptée à une application topique sur la peau, les muqueuses ou les phanères. According to one example, the cosmetic use of coral mucus, advantageously all or part of the coral mucus, in form, is suitable for topical application to the skin, mucous membranes or integuments.
Selon un exemple, l’utilisation cosmétique du mucus de corail, avantageusement de tout ou partie du mucus corail sous forme, est adaptée sous la forme d’un shampoing, par exemple liquide ou solide, d’un savon, d’un gel, d’une crème, d’une lotion, d’un baume, d’un spray, d’un masque, d’un dentifrice par exemple à pâte mole ou dure. According to one example, the cosmetic use of coral mucus, advantageously all or part of the coral mucus in form, is suitable in the form of a shampoo, for example liquid or solid, of a soap, of a gel, a cream, a lotion, a balm, a spray, a mask, a toothpaste, for example with a soft or hard paste.
Selon un aspect, l’invention concerne un produit d’hygiène corporel ou un produit de soin cosmétique comprenant du mucus de corail, avantageusement de tout ou partie du mucus corail. Selon un aspect, l’invention concerne un shampoing, un savon, un gel, une crème, une lotion, un baume, un spray, un masque, un dentifrice comprenant du mucus de corail, avantageusement de tout ou partie du mucus corail. According to one aspect, the invention relates to a personal hygiene product or a cosmetic care product comprising coral mucus, advantageously all or part of the coral mucus. According to one aspect, the invention relates to a shampoo, a soap, a gel, a cream, a lotion, a balm, a spray, a mask, a toothpaste comprising coral mucus, advantageously all or part of the coral mucus.
Selon un aspect, l’invention concerne l’utilisation de la composition cosmétique et non thérapeutique pour : According to one aspect, the invention relates to the use of the cosmetic and non-therapeutic composition for:
- l’hydratation de la peau ou des muqueuses ou des phanères, - hydration of the skin or mucous membranes or appendages,
- lutter contre le vieillissement cutané, - fight against skin aging,
- lutter contre les imperfections cutanées, par exemple de types boutons et excès de sébum, par exemple de type acné, - fight against skin imperfections, for example pimples and excess sebum, for example acne,
- la réduction des rides et ridules, - reduction of fine lines and wrinkles,
- lutter contre la perte d’élasticité de la peau, - fight against the loss of elasticity of the skin,
- lutter contre la perte de brillance, de luminosité ou d’éclat de la peau, - fight against the loss of shine, luminosity or radiance of the skin,
- réduire la dilatation des pores, - reduce the dilation of pores,
- réduire l’épaississement de la couche superficielle de la peau, - reduce the thickening of the superficial layer of the skin,
- lutter contre des changements de couleur ou des irrégularités dans la pigmentation, une kératinisation anormale et/ou excessive de la peau, - un effet thermoprotecteur, - fight against color changes or irregularities in pigmentation, abnormal and/or excessive keratinization of the skin, - a thermoprotective effect,
- une protection de la barrière cutanée, - protection of the skin barrier,
- un maintien et une protection du microbiote cutané, - maintenance and protection of the skin microbiota,
- le renouvellement cellulaire, - cellular renewal,
- la fermeté de la peau. - the firmness of the skin.
Selon un aspect, l’invention concerne l’utilisation par application topique sur la peau, les muqueuses ou les phanères de la composition cosmétique et non thérapeutique. According to one aspect, the invention relates to the use by topical application to the skin, mucous membranes or appendages of the cosmetic and non-therapeutic composition.
Selon un aspect, l’invention concerne un complément alimentaire comprenant la composition.According to one aspect, the invention relates to a food supplement comprising the composition.
Selon un exemple, le complément alimentaire est configuré pour être sous la forme d’une dose, d’une gélule, d’une pastille, d’un comprimé, d’une pilule d’un sachet de poudre, d’ampoule de liquide, de flacon muni d'un compte-gouttes. According to an example, the food supplement is configured to be in the form of a dose, a capsule, a lozenge, a tablet, a pill, a sachet of powder, an ampoule of liquid , bottle fitted with a dropper.
Selon un aspect, l’invention concerne l’utilisation du complément alimentaire pour According to one aspect, the invention relates to the use of the food supplement for
- l’hydratation de la peau ou des muqueuses ou des phanères, - hydration of the skin or mucous membranes or appendages,
- lutter contre le vieillissement cutané, - fight against skin aging,
- la réduction des rides et ridules, - reduction of fine lines and wrinkles,
- lutter contre la perte d’élasticité de la peau, - fight against the loss of elasticity of the skin,
- lutter contre la perte de brillance, de luminosité ou d’éclat de la peau, - fight against the loss of shine, luminosity or radiance of the skin,
- réduire la dilatation des pores, - reduce the dilation of pores,
- réduire l’épaississement de la couche superficielle de la peau, - reduce the thickening of the superficial layer of the skin,
- lutter contre des changements de couleur ou des irrégularités dans la pigmentation, une kératinisation anormale et/ou excessive de la peau, - fight against color changes or irregularities in pigmentation, abnormal and/or excessive keratinization of the skin,
- une protection de la barrière cutanée, - protection of the skin barrier,
- un maintien et une protection du microbiote digestif ou cutané - maintenance and protection of the digestive or skin microbiota
- Améliorer le confort intestinal et digestif, - Improve intestinal and digestive comfort,
- Favoriser la perte de poids, - Promote weight loss,
- Réduire les aigreurs, les brûlures, les lourdeurs, les constipations ou les ballonnements,- Reduce soreness, burning, heaviness, constipation or bloating,
- Améliorer, maintenir et protéger le microbiote digestif, - Improve, maintain and protect the digestive microbiota,
- Favoriser le renouvellement cellulaire, - Promote cell renewal,
- La fermeté de la peau. - Firmness of the skin.
Selon un aspect, l’invention concerne l’utilisation du complément alimentaire par application orale du complément alimentaire. According to one aspect, the invention relates to the use of the food supplement by oral application of the food supplement.
Selon un aspect, l’invention concerne une composition destinée à une application thérapeutique pour : According to one aspect, the invention relates to a composition intended for therapeutic application for:
- Un effet anti-inflammatoire - An anti-inflammatory effect
- Un effet antibactérien - An antibacterial effect
- Un effet antiviral - An antiviral effect
- Un effet antioxydant, - An antioxidant effect,
- Le traitement de l’acné, - Treatment of acne,
- Le traitement de l’eczéma, - Treatment of eczema,
- La photoprotection cutanée, Selon un aspect, l’invention concerne un procédé d’obtention de mucus issu d’au moins un corail comprenant une étape de récupération du mucus par aspiration ou par gravité. - Skin photoprotection, According to one aspect, the invention relates to a method for obtaining mucus from at least one coral comprising a step of recovering the mucus by suction or by gravity.
On entend par un paramètre "sensiblement égal/supérieur/inférieur à" ou "de l'ordre de" une valeur donnée, que ce paramètre est égal/supérieur/inférieur à la valeur donnée, à plus ou moins 10 % près, voire à plus ou moins 5 % près, de cette valeur. By a parameter "substantially equal/greater/less than" or "of the order of" a given value is meant that this parameter is equal/greater/less than the given value, to within plus or minus 10%, or even to plus or minus 5% of this value.
On entend par « mucus », un liquide gélatineux, aqueux ou visqueux. Le mucus corallien est un mélange complexe de matière organique composé principalement de glucides (principalement des polysaccharides) et protéines, mais aussi de lipides qui est produit par les mucocytes de la couche épidermique corallienne de l’ectoderme à la surface du corail. “Mucus” means a gelatinous, aqueous or viscous liquid. Coral mucus is a complex mixture of organic matter composed mainly of carbohydrates (mainly polysaccharides) and proteins, but also of lipids which is produced by the mucocytes of the coral epidermal layer of the ectoderm on the surface of the coral.
On entend par « corail », un organisme vivant de la classe des Anthozoaires (au sein de l'embranchement des Cnidaires), caractérisé par un exosquelette calcaire (dur) ou protéinique (mou). Les coraux sont des animaux invertébrés. By “coral” we mean a living organism of the class Anthozoa (within the phylum Cnidaria), characterized by a calcareous (hard) or proteinaceous (soft) exoskeleton. Corals are invertebrate animals.
On entend par « mucus de corail » ou « mucus issu d’au moins un corail » du mucus ou un mélange de mucus. Préférentiellement, le mucus de corail selon l’invention est soit à l’état brut, c’est-à-dire non modifié suite à son prélèvement, à l’exception d’un traitement de stérilisation, dans ce cas le mucus est dans un état plus ou moins liquide couramment dénommé état visqueux, soit à l’état séché ou lyophilisé, c’est-à-dire non modifié à l’exception de sa déshydratation, le mucus est alors préférentiellement dans un état de poudre. Le mucus de corail s’entend également sous une forme solide sous sa température de solidification. A titre d’exemple, l’invention s’applique au mucus de corail congelé. “Coral mucus” or “mucus from at least one coral” means mucus or a mixture of mucus. Preferably, the coral mucus according to the invention is either in the raw state, that is to say unmodified following its collection, with the exception of a sterilization treatment, in this case the mucus is in a more or less liquid state commonly called viscous state, either in the dried or freeze-dried state, that is to say unmodified except for its dehydration, the mucus is then preferentially in a powder state. Coral mucus is also understood to be in a solid form below its solidification temperature. For example, the invention applies to frozen coral mucus.
On entend par « anti-âge », un effet destiné à lutter contre le vieillissement superficiel de la peau tel que par exemple la flaccidité, l'affaissement, les rides et ridules, la sécheresse, la déshydratation, la perte d’élasticité de la peau, la perte de brillance, de luminosité et d’éclat de la peau, la dilatation des pores, l’épaississement de la couche superficielle des changements de couleur ou des irrégularités dans la pigmentation, une kératinisation anormale et/ou excessive de la peau. The term “anti-aging” means an effect intended to combat superficial aging of the skin such as, for example, flaccidity, sagging, wrinkles and fine lines, dryness, dehydration, loss of elasticity of the skin. skin, loss of shine, luminosity and radiance of the skin, dilation of pores, thickening of the superficial layer, changes in color or irregularities in pigmentation, abnormal and/or excessive keratinization of the skin .
On entend par « hydratant » un produit qui hydrate la peau et la couche superficielle de l’épiderme et empêche sa déshydratation en reconstituant le film hydrolipidique, protection naturelle de la peau et toutes les propriétés qui en découlent. By “moisturizer” we mean a product that hydrates the skin and the surface layer of the epidermis and prevents its dehydration by reconstituting the hydrolipidic film, the natural protection of the skin and all the properties that result from it.
On entend par « protection aux UV » ou « photoprotection » les divers moyens capables de s’opposer aux dommages cutanés induits par les radiations solaires. By “UV protection” or “photoprotection” we mean the various means capable of opposing skin damage induced by solar radiation.
On entend par « radiations solaires » les rayonnements émis par le soleil et arrivant à la surface de la Terre en particulier les rayons UV-A et UV-B mais également les rayons infrarouges provoquant un échauffement de la peau. By “solar radiation” we mean the radiation emitted by the sun and arriving at the surface of the Earth, in particular UV-A and UV-B rays but also infrared rays causing heating of the skin.
On entend par un effet « probiotique », la protection du microbiote (ou flore) cutané(e) ou digestive des agressions extérieures. Lorsque des bactéries pathogènes tentent de s'installer, les probiotiques, qui sont des organismes microscopiques vivants (levures, virus, bactéries...), produisent des substances toxiques pour les détruire. By a “probiotic” effect we mean the protection of the skin or digestive microbiota (or flora) from external aggressions. When pathogenic bacteria try to establish themselves, probiotics, which are living microscopic organisms (yeasts, viruses, bacteria, etc.), produce toxic substances to destroy them.
On entend par un effet « thermoprotecteur », pour les cosmétiques capillaires, une protection contre la chaleur causée par exemple par un sèche-cheveux ou fer à friser. Par "cosmétiquement acceptable", ou « adapté à un « usage cosmétique » on entend compatible avec la peau et/ou les muqueuses et/ou les phanères, qui présente une couleur, une odeur et un toucher agréables et qui ne génère pas d'inconforts inacceptables (picotements, tiraillements, rougeurs), susceptibles de détourner le consommateur d'utiliser cette composition. By a “thermoprotective” effect, for hair cosmetics, we mean protection against heat caused for example by a hairdryer or curling iron. By "cosmetically acceptable", or "suitable for "cosmetic use" is meant compatible with the skin and/or mucous membranes and/or skin appendages, which has a pleasant color, odor and feel and which does not generate unacceptable discomfort (tingling, tightness, redness), likely to dissuade the consumer from using this composition.
On entend par « complément alimentaire » un produit tel que défini dans la Directive 2002/46/CE du Parlement européen et du Conseil, en date du 10 juin 2002, relative au rapprochement des législations des Etats membres concernant les compléments alimentaires. On entend par «complément alimentaire», une denrée alimentaire dont le but est de compléter le régime normal et qui constitue une source concentrée de nutriments ou d'autres substances ayant un effet nutritionnel ou physiologique seul ou combiné. “Food supplement” means a product as defined in Directive 2002/46/EC of the European Parliament and of the Council, dated June 10, 2002, relating to the approximation of the laws of the Member States relating to food supplements. The term “food supplement” means a food whose purpose is to supplement the normal diet and which constitutes a concentrated source of nutrients or other substances having a nutritional or physiological effect alone or in combination.
L’invention concerne une composition comprenant du mucus issu d’au moins un corail. The invention relates to a composition comprising mucus from at least one coral.
Le mucus est du mucus issu d’un seul corail ou un mélange de mucus issu de plusieurs coraux. Selon l’invention, le mucus est soit à l’état visqueux, soit à l’état sec par exemple sous forme de poudre. Le mucus est avantageusement du mucus brut, c’est-à-dire non modifié encore dénommé natif, à l’exception d’un traitement de stérilisation et/ou de lyophilisation ou déshydratation. Mucus is mucus from a single coral or a mixture of mucus from several corals. According to the invention, the mucus is either in a viscous state or in a dry state, for example in powder form. The mucus is advantageously raw mucus, that is to say unmodified still called native, with the exception of a sterilization and/or freeze-drying or dehydration treatment.
Selon une possibilité, le mucus s’entend comme tout ou partie du mucus. Le mucus ayant été ou non enrichi. Selon une possibilité, le mucus comprend des concentrations adaptées des différents composants. According to one possibility, mucus is understood as all or part of the mucus. The mucus having been enriched or not. According to one possibility, the mucus includes adapted concentrations of the different components.
Selon une possibilité de l’invention, le au moins un corail est choisi parmi les coraux durs de la famille des Acropora Acropora yongei, Porites, Hermatypic, Porites astreoides, Diploria strigosa, Montastrea annularis, Colpophyllia natans, Acropora palmata, Lobophyllia hemprichii, Fungia scutaria, Fungia repanda, Acropora danai, Pocillopora eydouxi, Pocillopora meandrian, Fungia fungites, Fungia repanda, Diaseris distorta, Fungia scutaria, Cycloseris costulata, Cycloseris doederleini, Cycloseris marginata, Fungia actiniformis, Fungia danai, Fungia echinata, Fungia fungites, Fungia granulosa, Fungia horridae, Fungia Klunzingeri, Fungia scruposa, Fungia sommmervillei, Platigyra sp., M. annularis, P. astreoides, F. scutaria, Palythoa sp., F. scutaria, Acropora spp., Montipora digitata, Euphyllia sp., Porites porites, Porites compressa, Acropora sp., Siderastrea siderea, Agaricia agaricites, Madracis mirabilis, Montastrea cavernosa, P. porites, Eusmilia fastigiata, Mussa angulosa, Favia fragum, Colpophyllia natans, D. strigosa, Cladocoral cespitosa, Mycetophyllia reesi. According to one possibility of the invention, the at least one coral is chosen from the hard corals of the Acropora family Acropora yongei, Porites, Hermatypic, Porites astreoides, Diploria strigosa, Montastrea annularis, Colpophyllia natans, Acropora palmata, Lobophyllia hemprichii, Fungia scutaria, Fungia repanda, Acropora danai, Pocillopora eydouxi, Pocillopora meandrian, Fungia fungites, Fungia repanda, Diaseris distorta, Fungia scutaria, Cycloseris costulata, Cycloseris doederleini, Cycloseris marginata, Fungia actiniformis, Fungia danai, Fungia echinata, Fungia fungites, Fungia granulosa, Fungia horridae, Fungia Klunzingeri, Fungia scruposa, Fungia sommervillei, Platigyra sp., M. annularis, P. astreoides, F. scutaria, Palythoa sp., F. scutaria, Acropora spp., Montipora digitata, Euphyllia sp., Porites porites, Porites compressa, Acropora sp., Siderastrea siderea, Agaricia agaricites, Madracis mirabilis, Montastrea cavernosa, P. porites, Eusmilia fastigiata, Mussa angulosa, Favia fragum, Colpophyllia natans, D. strigosa, Cladocoral cespitosa, Mycetophyllia reesi.
Selon une autre possibilité de l’invention, le au moins un corail est choisi parmi les coraux mous choisis parmi Sarcophyton sp., Lemnalia sp., Cespitularia sp., Rumphella aggregata, coelentérés de la mer Rouge, Lobophyton sp, Rhytisma fulvum fulvum et Xenia sp. According to another possibility of the invention, the at least one coral is chosen from soft corals chosen from Sarcophyton sp., Lemnalia sp., Cespitularia sp., Rumphella aggregata, coelenterates from the Red Sea, Lobophyton sp, Rhytisma fulvum fulvum and Xenia sp.
Selon une possibilité, la composition est constituée uniquement de mucus issu d’au moins un corail. According to one possibility, the composition consists solely of mucus from at least one coral.
Selon un mode de réalisation, la composition comprend au moins un excipient ou un véhicule adapté pour une application sous-cutanée. According to one embodiment, the composition comprises at least one excipient or a vehicle suitable for subcutaneous application.
Selon un mode de réalisation, la composition comprend au moins un excipient ou véhicule adapté pour une application topique. Selon un mode de réalisation, la composition comprend au moins un excipient ou véhicule adapté pour une administration orale. According to one embodiment, the composition comprises at least one excipient or vehicle suitable for topical application. According to one embodiment, the composition comprises at least one excipient or vehicle suitable for oral administration.
Selon une possibilité, la composition comprend au moins un excipient ou véhicule cosmétiquement acceptable. La composition est une composition cosmétique, non thérapeutique, c’est-à-dire que la composition cosmétique est une composition adaptée à une application cosmétique. According to one possibility, the composition comprises at least one cosmetically acceptable excipient or vehicle. The composition is a cosmetic, non-therapeutic composition, that is to say that the cosmetic composition is a composition suitable for cosmetic application.
La composition cosmétique est avantageusement destinée à une application topique. La composition cosmétique présente préférentiellement une forme adaptée à une application topique ou sous-cutanée. Préférentiellement, la composition cosmétique est destinée et avantageusement adaptée à une application sur la peau y compris les lèvres, les cheveux, les cils, les sourcils et/ou les ongles. La composition cosmétique est par exemple sous la forme d’un shampoing, d’un savon, d’un gel, d’une crème, d’une lotion, d’un baume, d’un spray. The cosmetic composition is advantageously intended for topical application. The cosmetic composition preferably has a form suitable for topical or subcutaneous application. Preferably, the cosmetic composition is intended and advantageously adapted for application to the skin including the lips, hair, eyelashes, eyebrows and/or nails. The cosmetic composition is for example in the form of a shampoo, a soap, a gel, a cream, a lotion, a balm, a spray.
La composition cosmétique est avantageusement destinée à être utilisée pour l’hydratation de la peau, des muqueuses ou des phanères, lutter contre le vieillissement cutané, la réduction des rides et ridules, lutter contre la perte d’élasticité de la peau, lutter contre la perte de brillance, de luminosité ou d’éclat de la peau, réduire la dilatation des pores, réduire l’épaississement de la couche superficielle de la peau, lutter contre des changements de couleur ou des irrégularités dans la pigmentation, une kératinisation anormale et/ou excessive de la peau, une protection de la barrière cutanée, une amélioration, un maintien et une protection du microbiote cutané, la thermoprotection des cheveux, favoriser le renouvellement cellulaire notamment cutané, améliorer la fermeté de la peau. The cosmetic composition is advantageously intended to be used for hydrating the skin, mucous membranes or appendages, combating skin aging, reducing wrinkles and fine lines, combating the loss of elasticity of the skin, combating loss of shine, luminosity or radiance of the skin, reduce the dilation of pores, reduce thickening of the superficial layer of the skin, combat color changes or irregularities in pigmentation, abnormal keratinization and/ or excess of the skin, protection of the skin barrier, improvement, maintenance and protection of the skin microbiota, thermoprotection of the hair, promote cell renewal, particularly in the skin, improve the firmness of the skin.
Selon une possibilité, la composition comprend un au moins un excipient ou véhicule configuré pour être utilisé comme complément alimentaire. L’invention concerne suivant un aspect, un complément alimentaire comprenant du mucus issu d’au moins un corail ou une composition comprenant du mucus issu d’au moins un corail telle que décrite ci-dessus. According to one possibility, the composition comprises at least one excipient or vehicle configured to be used as a food supplement. According to one aspect, the invention relates to a food supplement comprising mucus from at least one coral or a composition comprising mucus from at least one coral as described above.
Le complément alimentaire est avantageusement destiné à une administration orale. Le complément alimentaire présente préférentiellement une forme adaptée à une administration orale telle que par exemple un liquide ou pseudo-liquide tel que visqueux, c'est-à-dire sous une forme de sirop, de gel, de spray, d’ampoule, de gélule, de flacon muni d'un compte-gouttes ou tel que par exemple sous forme de dose solide telle qu’une capsule, une gélule, une pastille, un comprimé, une pilule, d’un cachet, un sachet de poudre. D’autres formes analogues de préparations liquides ou en poudre destinées à être prises en unités mesurées peuvent être utilisées. The food supplement is advantageously intended for oral administration. The food supplement preferably presents a form suitable for oral administration such as for example a liquid or pseudo-liquid such as viscous, that is to say in the form of syrup, gel, spray, ampoule, capsule, bottle fitted with a dropper or such as for example in the form of a solid dose such as a capsule, a capsule, a lozenge, a tablet, a pill, a cachet, a sachet of powder. Other similar forms of liquid or powder preparations intended to be taken in measured units may be used.
Avantageusement, le complément alimentaire est destiné à être utilisé sous forme de dose.Advantageously, the food supplement is intended to be used in dose form.
Selon un mode de réalisation, le complément alimentaire est destiné à être utilisé de manière journalière sous forme d'une dose, de 1 à 3 fois par jour, par exemple le matin, le midi et/ou le soir. According to one embodiment, the food supplement is intended to be used daily in the form of a dose, 1 to 3 times per day, for example in the morning, midday and/or evening.
Le complément alimentaire est avantageusement destiné à être utilisé pour l’hydratation de la peau, des muqueuses ou des phanères, lutter contre le vieillissement cutané, la réduction des rides et ridules, lutter contre la perte d’élasticité de la peau, lutter contre la perte de brillance, de luminosité ou d’éclat de la peau, réduire la dilatation des pores, réduire l’épaississement de la couche superficielle de la peau, lutter contre des changements de couleur ou des irrégularités dans la pigmentation, une kératinisation anormale et/ou excessive de la peau, une protection de la barrière cutanée, une amélioration de la fermeté, une amélioration, un maintien et une protection du microbiote digestif ou cutané, améliorer le confort intestinal et digestif, favoriser la perte de poids ou réduire les aigreurs, les brûlures, les lourdeurs, les constipations ou les ballonnements. The food supplement is advantageously intended to be used for hydration of the skin, mucous membranes or appendages, combating skin aging, reducing wrinkles and fine lines, combating the loss of elasticity of the skin, combating loss of shine, luminosity or radiance of the skin, reduce the dilation of pores, reduce the thickening of the superficial layer of the skin, combat color changes or irregularities in pigmentation, abnormal and/or excessive keratinization of the skin , protection of the skin barrier, improvement of firmness, improvement, maintenance and protection of the digestive or skin microbiota, improve intestinal and digestive comfort, promote weight loss or reduce soreness, burning, heaviness , constipation or bloating.
Selon une possibilité, la composition comprend au moins un excipient ou véhicule pharmaceutiquement acceptable. La composition est une composition thérapeutique, c’est-à-dire que la composition est une composition adaptée à une application thérapeutique. According to one possibility, the composition comprises at least one pharmaceutically acceptable excipient or vehicle. The composition is a therapeutic composition, that is to say the composition is a composition suitable for therapeutic application.
L’invention concerne à cet effet une composition comprenant du mucus issu d’au moins un corail destinée à une application thérapeutique. La composition thérapeutique est avantageusement destinée à une application topique ou sous-cutanée ou par administration orale. La composition thérapeutique présente préférentiellement une forme adaptée à une application topique ou sous- cutanée ou orale. Préférentiellement, la composition thérapeutique est destinée et avantageusement adaptée à une application sur la peau y compris les lèvres, les cheveux, les cils, les sourcils et/ou les ongles. La composition thérapeutique est par exemple sous la forme d’un shampoing, d’un savon, d’un gel, d’une crème, d’une lotion, d’un baume, d’un spray. La composition thérapeutique est également adaptée à une administration orale en étant par exemple sous une forme de sirop, de gel, de spray, d’ampoule, de gélule, de flacon muni d'un compte-gouttes ou tel que par exemple sous forme de dose solide telle qu’une capsule, une gélule, une pastille, un comprimé, une pilule, d’un cachet, un sachet de poudre. La composition cosmétique est également adaptée à une administration sous-cutanée par exemple par injection. La composition est avantageusement destinée à être utilisée pour une application thérapeutique pour un effet anti-inflammatoire, un effet antibactérien, un effet antiviral, un traitement de l’acné, un traitement de l’eczéma, la photoprotection cutanée, un effet antioxydant, une réparation cellulaire. To this end, the invention relates to a composition comprising mucus from at least one coral intended for a therapeutic application. The therapeutic composition is advantageously intended for topical or subcutaneous application or by oral administration. The therapeutic composition preferably has a form suitable for topical or subcutaneous or oral application. Preferably, the therapeutic composition is intended and advantageously adapted for application to the skin including the lips, hair, eyelashes, eyebrows and/or nails. The therapeutic composition is for example in the form of a shampoo, a soap, a gel, a cream, a lotion, a balm, a spray. The therapeutic composition is also suitable for oral administration by being for example in the form of a syrup, gel, spray, ampoule, capsule, bottle fitted with a dropper or such as for example in the form of solid dose such as a capsule, a capsule, a lozenge, a tablet, a pill, a cachet, a sachet of powder. The cosmetic composition is also suitable for subcutaneous administration, for example by injection. The composition is advantageously intended to be used for a therapeutic application for an anti-inflammatory effect, an antibacterial effect, an antiviral effect, treatment of acne, treatment of eczema, skin photoprotection, an antioxidant effect, cellular repair.
A titre d’exemple, la quantité de mucus dans les applications cosmétiques est comprise entre 0,5% et 50% en poids du poids total de la composition finale. For example, the quantity of mucus in cosmetic applications is between 0.5% and 50% by weight of the total weight of the final composition.
A titre d’exemple, la quantité de mucus dans les applications thérapeutique est comprise entre 50,5% et 100% en poids du poids total de la composition finale. For example, the quantity of mucus in therapeutic applications is between 50.5% and 100% by weight of the total weight of the final composition.
A titre d’exemple, la quantité de mucus dans les applications de complément alimentaire est comprise entre 0,5% et 100% en poids du poids total de la composition finale. For example, the quantity of mucus in food supplement applications is between 0.5% and 100% by weight of the total weight of the final composition.
Selon un autre aspect, l’invention concerne un procédé d’obtention de mucus issu d’au moins un corail. Le procédé selon l’invention comprend une étape de récupération du mucus avantageusement sans endommager le corail. Le corail n’est pas détruit, n’est pas coupé. Le corail reste intact. Le procédé selon l’invention est non-invasif. According to another aspect, the invention relates to a process for obtaining mucus from at least one coral. The method according to the invention comprises a step of recovering the mucus advantageously without damaging the coral. The coral is not destroyed, is not cut. The coral remains intact. The method according to the invention is non-invasive.
Selon une possibilité préférée, l’étape de récupération est réalisée par aspiration du mucus ou par gravité. Plus précisément, le corail est retourné pour prélever le mucus par gravité ou le mucus peut être également collecté avec une seringue par aspiration. According to a preferred possibility, the recovery step is carried out by suction of the mucus or by gravity. More precisely, the coral is turned over to collect the mucus by gravity or the mucus can also be collected with a syringe by aspiration.
Selon une possibilité, le procédé comprend une étape préliminaire à l’étape de récupération qui est une étape de retrait du corail de l’eau. According to one possibility, the process comprises a step preliminary to the recovery step which is a step of removing the coral from the water.
Selon une possibilité, le procédé comprend une étape postérieure à l’étape de retrait du corail de l’eau qui est une étape d’élimination d’excès d’eau, plus précisément le corail est épongé. According to one possibility, the process comprises a step subsequent to the step of removing the coral from the water which is a step of eliminating excess water, more precisely the coral is sponged.
Selon une possibilité, le procédé comprend une étape de stimulation de la production de mucus avant l’étape de récupération et préférentiellement postérieure à l’étape de retrait du corail de l’eau et préférentiellement postérieure à l’étape d’élimination de l’excès d’eau. À titre d’exemple, l’étape de stimulation de la production de mucus est réalisée par contact avec l’air et/ou par agitation avec une tige de verre. According to one possibility, the method comprises a step of stimulating the production of mucus before the recovery step and preferably after the step of removing the coral from the water and preferentially after the step of eliminating the excess water. For example, the step of stimulating mucus production is carried out by contact with air and/or by agitation with a glass rod.
Avantageusement, le procédé selon l’invention comprend une étape de stérilisation du mucus. Préférentiellement, l’étape de stérilisation est réalisée en exposant le mucus un temps prédéfini à des radiations UV par exemple une lampe UV. Cette étape permet de supprimer les microorganismes, préférentiellement les virus et parasites, du mucus sans dégrader la structure primaire du mucus. Advantageously, the method according to the invention comprises a step of sterilizing the mucus. Preferably, the sterilization step is carried out by exposing the mucus for a predefined time to UV radiation, for example a UV lamp. This step makes it possible to remove microorganisms, preferably viruses and parasites, from the mucus without degrading the primary structure of the mucus.
À titre d’exemple, la stérilisation est réalisée en exposant le mucus sous une lampe à UV pendant un temps prédéfini par exemple de l’ordre de deux heures dans un tube de type Eppendorf®, ou par irradiation aux photons gamma pendant un temps prédéfini. Selon une possibilité, le tube est ensuite fermé et placé dans une cryoboîte en papier. La boîte entière est ensuite traitée aux photons gamma à une dose de 25 à 50 kGy en appliquant un procédé standard commercial.For example, sterilization is carried out by exposing the mucus under a UV lamp for a predefined time, for example of the order of two hours in an Eppendorf® type tube, or by irradiation with gamma photons for a predefined time. . According to one possibility, the tube is then closed and placed in a paper cryobox. The entire box is then treated with gamma photons at a dose of 25 to 50 kGy using a standard commercial process.
Avantageusement, le procédé selon l’invention comprend une étape de traitement antibiotique du mucus. Le mucus est soumis à au moins un antibiotique ou un plusieurs antibiotiques sélectionnés pour détruire certaines bactéries et en conserver d’autres. Cette étape est particulièrement utile dans le cas d’un usage comme probiotique. Advantageously, the method according to the invention comprises a step of antibiotic treatment of the mucus. The mucus is subjected to at least one antibiotic or several antibiotics selected to destroy certain bacteria and preserve others. This step is particularly useful when used as a probiotic.
Préférentiellement, la composition cosmétique et/ou le complément alimentaire sont formulés à partir d’ingrédients naturels. Preferably, the cosmetic composition and/or the food supplement are formulated from natural ingredients.
Selon une possibilité, l’invention concerne un procédé comprenant l’application cosmétique de mucus de corail, avantageusement de tout ou partie du mucus de corail. Préférentiellement, l’application cosmétique comprend une application topique. Préférentiellement, l’application cosmétique comprend l’application sur la peau y compris les lèvres, les cheveux, les cils, les sourcils et/ou les ongles. Selon une possibilité, le procédé comprend l’application cosmétique d’une composition comprenant du mucus de corail. According to one possibility, the invention relates to a process comprising the cosmetic application of coral mucus, advantageously all or part of the coral mucus. Preferably, the cosmetic application comprises a topical application. Preferably, the cosmetic application includes application to the skin including the lips, hair, eyelashes, eyebrows and/or nails. According to one possibility, the method comprises the cosmetic application of a composition comprising coral mucus.
Exemple 1 - composition cosmétique pour une crème, une lotion ou un gel : Example 1 - cosmetic composition for a cream, lotion or gel:
Mucus de corail, eau, glycérine biologique, Butyrospermum Parkii biologique (beurre de karité), huile de Coco Nucifera (noix de coco) biologique, huile de graines de Sim-mondsia Chinensis (Jojoba) biologique, olivate de cétéaryle, oli-vate de sorbitan, polysaccharide de graines de Cassia Angustifolia , extrait de ferment d'Alteromonas, esters de jojoba, cire de graines, polyglycérine-3, bêta-glucane, algine, gomme de xanthane, huile essentielle biologique d'écorce de Cedrus Atlantica (bois de cèdre) et huile de salvia officinalis (sauge), vitamine E. 2 - une crème, une lotion ou un qel : Coral Mucus, Water, Organic Glycerin, Organic Butyrospermum Parkii (Shea Butter), Organic Coco Nucifera (Coconut) Oil, Organic Sim-mondsia Chinensis (Jojoba) Seed Oil, Cetearyl Olivate, Olivate sorbitan, Cassia Angustifolia seed polysaccharide, Alteromonas ferment extract, jojoba esters, seed wax, polyglycerin-3, beta-glucan, algin, xanthan gum, organic essential oil from Cedrus Atlantica bark (wood of cedar) and salvia officinalis (sage) oil, vitamin E. 2 - a cream, lotion or qel:
Mucus de corail, eau, triglycéride caprylique/caprique, squalane (olive), dipalmitoyl hydroxyproline, glycérine, alcool cétéarylique, cétéaryl glucoside, huile d'Helianthus Annuus (graines de tournesol), alkyl glucoside, stéarate de glycéryle, acide stéarique,Coral Mucus, Water, Caprylic/Capric Triglyceride, Squalane (Olive), Dipalmitoyl Hydroxyproline, Glycerin, Cetearyl Alcohol, Cetearyl Glucoside, Helianthus Annuus (Sunflower Seed) Oil, Alkyl Glucoside, Glyceryl Stearate, Stearic Acid,
Leuconostoc/Radish Root Ferment Fil-trate, Hydroxyethylcellulose, huile de Persea Gratissima (Avocat), Huile de graines de Sim-mondsia Chinensis (Jojoba), Capryloyl Glycine, Undecy-lenoyl Glycine, Glycine, Extrait de fleur de Calendula Officinalis. Leuconostoc/Radish Root Ferment Fil-trate, Hydroxyethylcellulose, Persea Gratissima (Avocado) Oil, Sim-mondsia Chinensis (Jojoba) Seed Oil, Capryloyl Glycine, Undecy-lenoyl Glycine, Wisteria, Calendula Officinalis Flower Extract.
Exemple 3 - complément alimentaire sous forme de qélule à prise journalière : Example 3 - food supplement in the form of a daily dose:
- Mucus de Corail (280 mg pour 1 gélule) - Anti-agglomérant : stéarate de magnésium végétal- Coral Mucus (280 mg for 1 capsule) - Anti-caking agent: vegetable magnesium stearate
- Enveloppe gélatine : chlorophylle nature Exemple 4- procédé de récupération de mucus - Gelatin envelope: natural chlorophyll Example 4- mucus recovery process
Le corail choisi est Acropora yongei. Le corail est sorti de l’aquarium. Le corail est avantageusement retourné et préférentiellement exposer à l'air pendant un temps prédéfini, par exemple 10 secondes avantageusement pour réduire le stress des coraux. Le mucus est ensuite collecté directement dans un tube en verre ou Falcon®. The coral chosen is Acropora yongei. The coral is out of the aquarium. The coral is advantageously turned over and preferably exposed to the air for a predefined time, for example 10 seconds advantageously to reduce the stress of the corals. The mucus is then collected directly into a glass or Falcon® tube.
5 - procédé de récupération de mucus 5 - mucus recovery process
Le corail choisi est Acropora yongei. Le corail est sorti de l’aquarium. Le corail est avantageusement retourné et préférentiellement exposer à l'air et stimuler mécaniquement pendant un temps prédéfini, par exemple 5 secondes avantageusement pour réduire le stress des coraux. La stimulation mécanique est réalisée par une tige de préférence en verre que l’on fait coulisser le long du corail. Le mucus est ensuite collecté directement dans un tube en verre ou Falcon®. The coral chosen is Acropora yongei. The coral is out of the aquarium. The coral is advantageously turned over and preferably exposed to the air and mechanically stimulated for a predefined time, for example 5 seconds advantageously to reduce stress on the corals. Mechanical stimulation is carried out by a rod, preferably made of glass, which is slid along the coral. The mucus is then collected directly into a glass or Falcon® tube.
Exemple 6- procédé de récupération de mucus Example 6- mucus recovery process
Le corail choisi est Acropora yongei. Le corail est maintenu dans l’aquarium. Le corail est stimulé mécaniquement pendant un temps prédéfini, par exemple 5 secondes avantageusement pour réduire le stress des coraux. La stimulation mécanique est réalisée par une tige de préférence en verre que l’on fait coulisser le long du corail ou par des jets d’eau. Le mucus est ensuite collecté par une pipette. The coral chosen is Acropora yongei. The coral is maintained in the aquarium. The coral is mechanically stimulated for a predefined time, for example 5 seconds advantageously to reduce stress on the corals. Mechanical stimulation is carried out by a rod, preferably made of glass, which is slid along the coral or by jets of water. The mucus is then collected by a pipette.
L’invention n’est pas limitée aux modes de réalisations précédemment décrits et s’étend à tous les modes de réalisation couverts par l’invention. The invention is not limited to the embodiments previously described and extends to all the embodiments covered by the invention.

Claims

Revendications Claims
1 . Composition comprenant du mucus issu d’au moins un corail. 1. Composition comprising mucus from at least one coral.
Composition selon la revendication 1 comprenant au moins un excipient ou véhicule adapté pour une application topique. Composition according to claim 1 comprising at least one excipient or vehicle suitable for topical application.
Composition selon la revendication 1 comprenant au moins un excipient ou véhicule adapté pour une application sous-cutanée. Composition according to claim 1 comprising at least one excipient or vehicle suitable for subcutaneous application.
Composition selon la revendication 1 comprenant au moins un excipient ou véhicule adapté pour une administration orale. Composition according to claim 1 comprising at least one excipient or vehicle suitable for oral administration.
5. Composition selon l’une quelconque des revendications précédentes dans laquelle le au moins un corail est choisi parmi les coraux producteurs de mucus mous ou les coraux producteurs de mucus durs. 5. Composition according to any one of the preceding claims in which the at least one coral is chosen from soft mucus-producing corals or hard mucus-producing corals.
6. Composition selon l’une quelconque des revendications précédentes dans laquelle le mucus est à l’état visqueux ou à l’état sec. 6. Composition according to any one of the preceding claims in which the mucus is in the viscous state or in the dry state.
7. Utilisation cosmétique et non thérapeutique du mucus issu d’au moins un corail. 7. Cosmetic and non-therapeutic use of mucus from at least one coral.
8. Utilisation selon la revendication précédente sous la forme d’un shampoing, d’un savon, d’un gel, d’une crème, d’une lotion, d’un baume, d’un spray, d’un dentifrice. 8. Use according to the preceding claim in the form of a shampoo, a soap, a gel, a cream, a lotion, a balm, a spray, a toothpaste.
9. Utilisation selon l’une quelconque des deux revendications précédentes sous forme adaptée à une application topique sur la peau, les muqueuses ou les phanères. 9. Use according to any one of the two preceding claims in form suitable for topical application to the skin, mucous membranes or integuments.
10. Complément alimentaire comprenant la composition selon l’une quelconque des revendications 1 , 4 ou, 5 ou 6 en combinaison de la revendication 4. 10. Food supplement comprising the composition according to any one of claims 1, 4 or 5 or 6 in combination with claim 4.
11 . Complément alimentaire selon la revendication précédente configuré pour être sous la forme d’une dose, d’une gélule, d’une pastille, d’un comprimé, d’une pilule d’un sachet de poudre, d’ampoule de liquide, de flacon muni d'un compte-gouttes. 11. Food supplement according to the preceding claim configured to be in the form of a dose, a capsule, a lozenge, a tablet, a pill, a sachet of powder, an ampoule of liquid, bottle fitted with a dropper.
12. Complément alimentaire selon l’une quelconque des deux revendications précédentes sous forme adaptée à une application orale du complément alimentaire. 12. Food supplement according to any one of the two preceding claims in form suitable for oral application of the food supplement.
13. Composition selon l’une quelconque des revendications 1 à 6 destinée à une application thérapeutique pour : 13. Composition according to any one of claims 1 to 6 intended for therapeutic application for:
- un effet anti-inflammatoire, - an anti-inflammatory effect,
- un effet antiviral, - an antiviral effect,
- un effet antioxydant, - an antioxidant effect,
- le traitement de l’acné, - acne treatment,
- le traitement de l’eczéma, - the treatment of eczema,
- la photoprotection cutanée. - skin photoprotection.
PCT/EP2023/073961 2022-09-01 2023-08-31 Composition comprising coral mucus and use thereof WO2024047195A1 (en)

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