WO2024012087A1 - 一种生物样本蜂巢式存储罐 - Google Patents

一种生物样本蜂巢式存储罐 Download PDF

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Publication number
WO2024012087A1
WO2024012087A1 PCT/CN2023/098015 CN2023098015W WO2024012087A1 WO 2024012087 A1 WO2024012087 A1 WO 2024012087A1 CN 2023098015 W CN2023098015 W CN 2023098015W WO 2024012087 A1 WO2024012087 A1 WO 2024012087A1
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WO
WIPO (PCT)
Prior art keywords
storage tank
honeycomb
storage
plate
biological sample
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Application number
PCT/CN2023/098015
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English (en)
French (fr)
Inventor
瞿建国
尹灶发
薛运锋
Original Assignee
上海原能细胞生物低温设备有限公司
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Application filed by 上海原能细胞生物低温设备有限公司 filed Critical 上海原能细胞生物低温设备有限公司
Publication of WO2024012087A1 publication Critical patent/WO2024012087A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02—Internal fittings
    • B65D25/10—Devices to locate articles in containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient

Definitions

  • the utility model relates to a biological sample honeycomb storage tank, which belongs to the technical field of biological sample storage.
  • the deep cryogenic biological sample bank is an important basic equipment for current research in the medical and biological fields. Through cryogenic preservation in liquid nitrogen, biological tissues such as blood, stem cells, and immune cells can maintain their activity for a long time.
  • biological tissues such as blood, stem cells, and immune cells can maintain their activity for a long time.
  • the extracted biological samples are stored in cryogenic tubes, and then the cryogenic tubes are stored in aluminum tubes; and then the aluminum tubes are placed in a liquid nitrogen sample storage tank for storage.
  • cryovials stored at deep-low temperatures from typical sample storage tanks
  • the cryovials need to be extracted out of the tank first, and then the tubes are picked and transferred.
  • the cryovial will enter normal temperature or the temperature will return to normal temperature, which will bring the risk of sample damage.
  • application number CN201821964119.0 there is a known biological sample transfer and storage mechanism, application number CN201821964119.0.
  • the extraction rack or cryopreservation tube of this solution needs to be transferred to the operation cabin, which is easily exposed to normal temperature and affects the survival of the biological sample.
  • This utility model is to provide a biological sample honeycomb storage tank, which can solve the problem of the entire cold chain during the extraction process of cryopreservation tubes, and at the same time can solve the problem of enhancing the continuous cold preservation function of liquid nitrogen in the tank.
  • a biological sample honeycomb storage tank including a storage tank body composed of a storage tank body and a storage tank cover.
  • the storage tank body is provided with a fixed operating mechanism, a rotating storage mechanism and liquid nitrogen from top to bottom. Cooling mechanism;
  • the fixed operating mechanism is provided below the operating window opened on the storage tank cover, and is used for extracting and/or picking up frozen tubes inside the storage tank;
  • the rotary storage mechanism is used to place aluminum tubes containing cryopreservation tubes and can drive the aluminum tubes to be extracted and or picked up under the fixed operating mechanism;
  • the liquid nitrogen cooling mechanism is used to store liquid nitrogen and continuously keep the fixed operating mechanism and rotating storage mechanism cold from the bottom of the storage tank.
  • the side walls and bottom walls of the storage tank are provided with vacuum chambers, and a vacuum sandwich shell is also provided on the outside of the storage tank.
  • the operation window is provided with a removable cover.
  • the operation window and the cover are elongated and overlap with the rotary unit of the rotary storage mechanism.
  • the upper part of the blocking cover is provided with an extraction part, which can be coupled with a mechanical arm outside the storage tank body to open and close the blocking cover.
  • the area between the storage tank cover and the rotating storage mechanism that is away from the fixed operating mechanism is also filled with a thermal insulation structure.
  • the rotating storage mechanism includes an upper honeycomb storage plate, a lower honeycomb storage plate and a central rotating shaft.
  • the upper honeycomb storage plate and the lower honeycomb storage plate are spaced up and down on the central rotating shaft to form a honeycomb type for storing aluminum tubes. structure, the intermediate positions of both are rotationally connected to the central rotating shaft.
  • the circumferential edges of the upper honeycomb storage plate and the lower honeycomb storage plate are fixedly connected through a plurality of evenly distributed supports;
  • the upper peripheral portion of the upper honeycomb storage plate is provided with a rotating internal ring gear, which is connected to the rotating driving member outside the storage tank body through gear meshing.
  • the support member is a support rod with a hollow structure, with cooling air inlets and cooling air outlets respectively provided at both ends.
  • the outer periphery of the upper honeycomb storage plate is slidably connected to the storage tank body through a guide structure.
  • the guide structure includes an annular guide rail fixedly connected to the outer periphery of the upper honeycomb storage plate and several guide movable blocks fixedly connected around the inner wall of the storage tank.
  • the guide movable blocks are slidably installed on the on the circular guide rail.
  • the fixed operating mechanism includes a guide plate and a plate rack arranged side by side in the rotation direction of the rotary storage mechanism.
  • the guide plate is provided with a tube picking hole for extracting the frozen storage tube.
  • the plate rack Used for picking frozen vials.
  • the plate rack is also provided with a temperature sensor for detecting the temperature of the plate rack stored on the guide plate.
  • the fixed operating mechanism is connected to the radial position of the cross-section of the storage tank through a fixed plate, and is arranged close to the top of the rotating storage mechanism, and a through nitrogen discharge port is opened on the fixed plate.
  • the liquid nitrogen cooling mechanism includes a central inner cylinder, the central rotating shaft is rotatably arranged on the upper part of the central inner cylinder, and the upper and lower ends of the central inner cylinder are respectively provided with a nitrogen spray port and an inlet. liquid tube.
  • a fixed operating mechanism is used to directly extract cryogenic tubes and pick tubes inside the storage tank in the deep-low temperature environment area, thereby avoiding the risk of damage to the cryogenic tubes caused by exposure to normal temperature;
  • the liquid nitrogen cooling mechanism at the bottom is used to store a certain amount of liquid nitrogen, achieving the purpose of continuously providing a cooling effect for the storage tank, and ensuring the storage area and operation of the fixed operating mechanism and rotating storage mechanism.
  • the area is always in a deep low temperature environment.
  • Figure 1 is a half-sectional view of the biological sample honeycomb storage tank of the present invention
  • FIG. 2 is a schematic diagram of the internal structure of the biological sample honeycomb storage tank of the present invention, with the fixing plate and other accessories removed;
  • Figure 3 is a partial enlarged view of position A in Figure 2;
  • Figure 4 is a schematic diagram of the internal structure of the biological sample honeycomb storage tank of the present invention, which includes a fixing plate and some accessories.
  • the marks in the figure indicate: 1-Storage tank body; 11-Storage tank body; 111-Vacuum chamber; 12-Storage tank cover; 121-Operation window; 122-Block cover; 1221-Extraction part; 13-Shell; 131-Vacuum interlayer; 2-Fixed operating mechanism; 21-Guide plate; 211-Pipe picking hole; 22-Plate frame; 221-Temperature sensor; 23- Fixed plate; 231-through nitrogen discharge port; 3-rotating storage mechanism; 31-upper honeycomb storage plate; 32-lower honeycomb storage plate; 33-center rotating shaft; 34- Support member; 351-rotating internal ring gear; 352-gear; 36-rotating drive member; 37-guide structure; 371-annular guide rail; 372-guide movable block; 4-liquid nitrogen cooling mechanism; 41-center inner cylinder; 411-nitrogen spray port; 412-liquid inlet pipe; 5-Thermal insulation structure.
  • This embodiment provides a biological sample honeycomb storage tank, which includes a storage tank body 1 composed of a storage tank body 11 and a storage tank cover 12.
  • the storage tank body 11 is provided with fixed fixings in sequence from top to bottom.
  • the fixed operating mechanism 2 is provided below the operating window 121 opened on the storage tank cover 12, and is used to extract and/or pick up frozen tubes inside the storage tank body 11;
  • the rotating storage mechanism 3 is used to place aluminum tubes containing cryopreservation tubes and can drive the aluminum tubes to be extracted and or picked up to the bottom of the fixed operating mechanism 2;
  • the liquid nitrogen cooling mechanism 4 is used to store liquid nitrogen and continuously keep the fixed operating mechanism 2 and the rotating storage mechanism 3 cold from the bottom of the storage tank 11 .
  • the fixed operating mechanism 2 By disposing the fixed operating mechanism 2 below the operating window 121 opened on the storage tank cover 12 and above the rotating storage mechanism 3, it is possible to directly access the interior of the storage tank 11 in the deep and low temperature environment area. Perform operations such as extracting cryovials and picking tubes to avoid the risk of damage to cryovials caused by exposure to normal temperature.
  • the liquid nitrogen cooling mechanism 4 provided below the fixed operating mechanism 2 and the rotating storage mechanism 3, a certain amount of liquid nitrogen can be stored, and the entire storage and operation process of the cryogenic tubes can be continuously provided from the bottom of the storage tank 11. Cold chain environment.
  • the side walls and bottom walls of the storage tank body 11 are provided with vacuum chambers 111 , and the outer shell 13 of the storage tank body 11 is also provided with a vacuum interlayer 131 .
  • the outer shell 13 is used to further protect and install the storage tank body 11, and its vacuum sandwich layer 131 is used to further keep the temperature of the storage tank body 11 cold.
  • the side walls and bottom walls of the storage tank 11 of the vacuum chamber 111 are used to maintain the deep low temperature inside.
  • a removable cover 122 is provided at the operation window 121 .
  • the cover 122 is used to open when it is necessary to operate the freezing tube through the fixed operating mechanism 2, and to close it in time after use to reduce the amount of liquid nitrogen used.
  • the operation window 121 and the cover 122 are both elongated and overlap with the rotation unit of the rotation storage mechanism 3 .
  • the elongated design that overlaps the rotary unit of the rotary storage mechanism 3 means that all the aluminum tubes on the rotary storage mechanism 3 can appear in the operation window 121 in sequence through the rotary unit, so that they will not be missed.
  • the best effect is to reduce the window size as much as possible under the premise.
  • the upper part of the blocking cover 122 is provided with an extraction part 1221, which can be coupled with a mechanical arm outside the storage tank body 1 to open and close the blocking cover 122.
  • an extraction part 1221 is provided.
  • the specific structure of the extraction part 1221 can be a hook part or a magnetic suction part, which is connected to the mechanical arm in a hanging or adsorbing manner, and can then be taken out or put back.
  • the area between the storage tank cover 12 and the rotating storage mechanism 3 that is away from the fixed operating mechanism 2 is also filled with a thermal insulation structure 5 .
  • the thermal insulation structure 5 mainly provides cold insulation from the storage tank cover 12 above, and together with the vacuum chamber 111 at the bottom and side and the shell 13 of the vacuum sandwich 131, a comprehensive thermal insulation system of the storage tank is constructed. At the same time, the thermal insulation structure 5 also focuses on ensuring the continuous low temperature of the fixed operating mechanism 2 and the rotating storage mechanism 3, saving nitrogen consumption.
  • the rotating storage mechanism 3 includes an upper honeycomb storage plate 31, a lower honeycomb storage plate 32 and a central rotating shaft 33.
  • the upper honeycomb storage plate 31 and the lower honeycomb storage plate 32 are arranged at intervals up and down on the A honeycomb structure for storing aluminum tubes is formed on the central rotating shaft 33 , and the intermediate positions of both are rotatably connected to the central rotating shaft 33 .
  • the structures of the upper honeycomb storage plate 31 and the lower honeycomb storage plate 32 are filled with holes that penetrate up and down for placing aluminum tubes. After they are spaced apart, they form a honeycomb structure as a whole on the central rotating shaft 33 . The entire honeycomb structure rotates with the central rotating shaft 33 and appears in the operation window 121 in order to prepare for operation needs.
  • the circumferential edges of the upper honeycomb storage plate 31 and the lower honeycomb storage plate 32 are fixedly connected through a plurality of evenly distributed supports 34;
  • the upper peripheral portion of the upper honeycomb storage plate 31 is provided with a rotating internal ring gear 351, which is meshed with the rotating driving member 36 outside the storage tank body 11 through a gear 352.
  • the supports 34 enhance the overall stability of the honeycomb structure.
  • the rotary driving member 36 may be a driving motor, and the gear 352 coaxially connected with the driving motor is meshed and connected with the rotating inner ring gear 351 of the upper honeycomb storage plate 31, thereby achieving the purpose of the driving motor directly driving the honeycomb structure to rotate. This is This transmission method improves the rotation accuracy and enables more precise rotation to select the required cryopreservation tubes.
  • the support member 34 is a support rod with a hollow structure, and its two ends are respectively provided with a cooling air inlet and a cooling air outlet.
  • the support rod of the hollow structure while connecting the upper honeycomb storage plate 31 and the lower honeycomb storage plate 32, also uses the cooling air inlet and cooling air outlet on it to conduct liquid nitrogen transmission, thereby enhancing the rotation storage
  • the continuous cold preservation function inside the mechanism 3 is also conducive to the upward transmission of liquid nitrogen.
  • the outer periphery of the upper honeycomb storage plate 31 is slidably connected to the storage tank body 11 through a guide structure 37 .
  • the arrangement of the guide structure 37 further improves the stability and reliability of the transmission process of realizing the rotation of the rotation storage mechanism 3 .
  • the guide structure 37 includes an annular guide rail 371 fixedly connected to the outer periphery of the upper honeycomb storage plate 31 and several guide movable blocks 372 fixedly connected to the inner wall of the storage tank 11, so The guide movable block 372 is slidably installed on the annular guide rail 371 .
  • the storage tank body 11 and the rotating storage mechanism 3 achieve relative circumferential sliding through a sliding structure composed of a guide movable block 372 and an annular guide rail 371 .
  • the fixed operating mechanism 2 includes a guide plate 21 and a plate rack 22 arranged side by side in the rotation direction of the rotary storage mechanism 3.
  • the guide plate 21 is provided with a device for extracting frozen storage tubes.
  • the tube picking hole 211, the plate rack 22 is used for picking the frozen tubes.
  • the guide plate 21 and the plate rack 22 are jointly located at the operating window 121. In order to provide full coverage, the guide plate 21 also needs to overlap with the rotary unit of the rotary storage mechanism 3.
  • the guide plate 21 is mainly used to place the frozen tube pick-up tubes in the aluminum tube into the plate rack. 22, and then adjust the required cryovials in the rack 22.
  • the plate rack 22 is also provided with a temperature sensor 221 for detecting the temperature of the plate rack 22 stored on the guide plate 21 . Convenient for further intelligent control and association use.
  • the fixed operating mechanism 2 is connected to the radial position of the cross-section of the storage tank body 11 through a fixed plate 23 and is arranged close to the top of the rotating storage mechanism 3.
  • the fixed plate 23 23 is provided with a through nitrogen discharge port 231.
  • the fixed plate 23 realizes the installation requirements of the fixed operating mechanism 2 and at the same time ensures the effective flow of liquid nitrogen by using the through nitrogen discharge port 231.
  • the through nitrogen discharge port 231 may be provided between the installation parts.
  • the fan-shaped notch can also be a strip-shaped through hole provided on the installation site, or both can be used at the same time.
  • the liquid nitrogen cooling mechanism 4 includes a central inner cylinder 41 , the central rotating shaft 33 is rotatably arranged on the upper part of the central inner cylinder 41 , and the upper and lower parts of the central inner cylinder 41 The ends are respectively provided with nitrogen injection ports 411 and liquid inlet pipes.
  • liquid nitrogen enters the central inner cylinder 41 from the outside through the liquid inlet pipe 412. A certain amount of liquid nitrogen is stored in the central inner cylinder 41, and at the same time, it continues to enter the storage tank 11 from the nitrogen spray port 411. Remove nitrogen to achieve the purpose of continuous cold preservation.

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Abstract

一种生物样本蜂巢式存储罐，包括由存储罐罐体（11）和存储罐盖体（12）组成的存储罐本体（1），存储罐罐体内部由上到下依次设有固定操作机构（2）、旋转存储机构（3）及液氮保冷机构（4）；固定操作机构设置在存储罐盖体上开设的操作窗口（121）下方，用于在存储罐罐体内部进行冻存管的提取和或挑管操作；旋转存储机构用于放置存放有冻存管的铝管并可将待提取和或挑管操作的铝管带动至固定操作机构下方；液氮保冷机构用于存储液氮并从存储罐罐体底部持续对固定操作机构、旋转存储机构进行保冷。该存储罐能够直接在深低温环境区域进行提取冻存管及挑管等操作，避免冻存管暴露在常温下造成损伤的风险，并能够实现持续为存储罐提供保冷的功能。

Description

一种生物样本蜂巢式存储罐 技术领域
本实用新型涉及一种生物样本蜂巢式存储罐，属于生物样本存储技术领域。
背景技术
深低温生物样本库是目前医药领域和生物领域研究工作重要的基础设备，通过液氮的低温保存可以让血液、干细胞和免疫细胞等生物组织长期保持活性。现有技术中均是将提取的生物样本存放在冻存管中，然后将冻存管存放在铝管内；再将铝管放入到液氮的样本存储罐中存放。
目前，通常的样本存储罐在提取处于深低温存储的冻存管时，都需要先将冻存管提取出到罐体外，然后再进行挑管及转运操作。但是这样冻存管就会进入常温或者温度回温都会带来样本损伤的风险。例如已知的一种生物样本转运储存机构，申请号CN201821964119.0，此方案的提取板架或冻存管需要转入操作舱，这样易暴露于常温下影响生物样本的存活。
实用新型内容
本实用新型目的是提供一种生物样本蜂巢式存储罐，可解决冻存管提取过程中的全程冷链的问题，同时可解决罐体内增强液氮持续保冷功能的问题。
本实用新型解决技术问题采用如下一种技术方案：
一种生物样本蜂巢式存储罐，包括由存储罐罐体和存储罐盖体组成的存储罐本体，所述存储罐罐体内部由上到下依次设有固定操作机构、旋转存储机构及液氮保冷机构；
所述固定操作机构设置在所述存储罐盖体上开设的操作窗口下方，用于在所述存储罐罐体内部进行冻存管的提取和或挑管操作；
所述旋转存储机构用于放置存放有冻存管的铝管并可将待提取和或挑管操作的铝管带动至所述固定操作机构下方；
所述液氮保冷机构用于存储液氮并从存储罐罐体底部持续对所述固定操作机构、旋转存储机构进行保冷。
可选的，所述存储罐罐体的侧壁及底壁均设有真空腔室，所述存储罐罐体的外部还设置有真空夹层的外壳。
可选的，所述操作窗口处设有可拆卸的挡盖。
可选的，所述操作窗口及挡盖均呈长条型，与所述旋转存储机构的回转单元重叠。
可选的，所述挡盖的上部设有提取部，可与存储罐本体外部的机械臂配合连接以开合挡盖。
可选的，所述存储罐盖体与所述旋转存储机构之间避开所述固定操作机构的区域还填充有保温结构。
可选的，所述旋转存储机构包括上蜂巢存储板、下蜂巢存储板及中心转轴，所述上蜂巢存储板和下蜂巢存储板上下间隔布置于所述中心转轴上形成存储铝管的蜂巢式结构，二者的中间位置均与所述中心转轴转动连接。
可选的，所述上蜂巢存储板与所述下蜂巢存储板的周向边缘通过均匀分布的多个支撑件固定连接；
所述上蜂巢存储板的上周边部设有转动内齿圈，与所述存储罐罐体外部的旋转驱动件通过齿轮啮合连接。
可选的，所述支撑件为中空结构的支撑杆，其两端分别开设有导冷进气口和导冷出气口。
可选的，所述上蜂巢存储板的外周通过导向结构与所述存储罐罐体可滑动连接。
可选的，所述导向结构包括固定连接在所述上蜂巢存储板外周的环形导轨以及固定连接所述存储罐罐体内壁四周的若干个导向活动块，所述导向活动块滑动安装在所述环形导轨上。
可选的，所述固定操作机构包括在所述旋转存储机构的转动方向上依次并列布置的导板和板架，所述导板上设有用于提取出冻存管的挑管孔，所述板架用于进行冻存管挑管。
可选的，所述板架上还设有温度传感器，用于检测板架存放在导板上的温度。
可选的，所述固定操作机构通过固定板连接在所述存储罐罐体的横截面径向位置，并靠近所述旋转存储机构的顶部布置，所述固定板上开设有贯通排氮口。
可选的，所述液氮保冷机构包括中心内筒体，所述中心转轴可转动的设置在所述中心内筒体上部，所述中心内筒体的上下端分别设有喷氮口和进液管。
本实用新型的上述技术方案具有如下有益效果：
通过在存储罐罐体内部由上到下依次设置固定操作机构、旋转存储机构及液氮保冷机构；
1)一方面利用固定操作机构直接在深低温环境区域的存储罐罐体内部进行提取冻存管及挑管等操作，避免了冻存管暴露在常温下造成损伤的风险；
2)另一方面，利用底部的液氮保冷机构，存储一定量的液氮，实现了持续为存储罐罐体提供保冷效果的目的，保障了固定操作机构、旋转存储机构所在的存储区域及操作区域始终处于深低温环境。
附图说明
图1为本实用新型生物样本蜂巢式存储罐的半剖视图；
图2为本实用新型生物样本蜂巢式存储罐的内结构示意图，其中去掉了固定板及其他附件；
图3为图2中A处的局部放大图；
图4为本实用新型生物样本蜂巢式存储罐的内结构示意图，其中包含了固定板和部分附件。
图中标记示意为：
1-存储罐本体；11-存储罐罐体；111-真空腔室；12-存储罐盖体；121-操
作窗口；122-挡盖；1221-提取部；13-外壳；131-真空夹层；
2-固定操作机构；21-导板；211-挑管孔；22-板架；221-温度传感器；23-
固定板；231-贯通排氮口；
3-旋转存储机构；31-上蜂巢存储板；32-下蜂巢存储板；33-中心转轴；34-
支撑件；351-转动内齿圈；352-齿轮；36-旋转驱动件；37-导向结构；371-环形导轨；372-导向活动块；
4-液氮保冷机构；41-中心内筒体；411-喷氮口；412-进液管；
5-保温结构。
具体实施方式
下面结合实施例及附图对本实用新型的技术方案作进一步阐述。
本实施例提供了一种生物样本蜂巢式存储罐，包括由存储罐罐体11和存储罐盖体12组成的存储罐本体1，所述存储罐罐体11内部由上到下依次设有固定操作机构2、旋转存储机构3及液氮保冷机构4；
所述固定操作机构2设置在所述存储罐盖体12上开设的操作窗口121下方，用于在所述存储罐罐体11内部进行冻存管的提取和或挑管操作；
所述旋转存储机构3用于放置存放有冻存管的铝管并可将待提取和或挑管操作的铝管带动至所述固定操作机构2下方；
所述液氮保冷机构4用于存储液氮并从存储罐罐体11底部持续对所述固定操作机构2、旋转存储机构3进行保冷。
通过设置在所述存储罐盖体12上开设的操作窗口121下方，同时位于所述旋转存储机构3上方的固定操作机构2，实现了直接在深低温环境区域的所述存储罐罐体11内部进行提取冻存管及挑管等操作，避免了冻存管暴露在常温下造成损伤的风险。通过设置在所述固定操作机构2和旋转存储机构3下方的液氮保冷机构4，能够存储一定量的液氮，持续从所述存储罐罐体11底部为冻存管的存储、操作提供全程冷链环境。
本实用新型进一步的实施方式，所述存储罐罐体11的侧壁及底壁均设有真空腔室111，所述存储罐罐体11的外部还设置有真空夹层131的外壳13。
外壳13用于进一步防护和安装所述存储罐罐体11，其真空夹层131用于进一步保冷存储罐罐体11温度。真空腔室111的所述存储罐罐体11的侧壁及底壁用于维持内部的深低温。
本实用新型进一步的实施方式，所述操作窗口121处设有可拆卸的挡盖122。挡盖122用来在需要通过所述固定操作机构2进行冻存管操作时打开，使用完及时关闭，以减少液氮使用量。
本实用新型进一步的实施方式，所述操作窗口121及挡盖122均呈长条型，与所述旋转存储机构3的回转单元重叠。
与所述旋转存储机构3的回转单元重叠的长条型设计，是指旋转存储机构3上的所有铝管都能够通过回转单元的形式依次出现在所述操作窗口121处，达到了不会遗漏的前提下尽量减少窗口尺寸的较佳效果。
本实用新型进一步的实施方式，所述挡盖122的上部设有提取部1221，可与存储罐本体1外部的机械臂配合连接以开合挡盖122。
为了更方便操作，设置了提取部1221，该提取部1221的具体结构可以为挂钩部或磁吸部，以悬挂或吸附的方式与机械臂连接，进而被取出或放回。
本实用新型进一步的实施方式，所述存储罐盖体12与所述旋转存储机构3之间避开所述固定操作机构2的区域还填充有保温结构5。
保温结构5主要从上方的所述存储罐盖体12进行保冷，与底部及侧部的真空腔室111、真空夹层131的外壳13一起构建起了存储罐全面的保温体系。同时，保温结构5也着重为固定操作机构2和旋转存储机构3的持续低温做了保障，节省了用氮量。
本实用新型进一步的实施方式，所述旋转存储机构3包括上蜂巢存储板31、下蜂巢存储板32及中心转轴33，所述上蜂巢存储板31和下蜂巢存储板32上下间隔布置于所述中心转轴33上形成存储铝管的蜂巢式结构，二者的中间位置均与所述中心转轴33转动连接。
上蜂巢存储板31和下蜂巢存储板32的构造，顾名思义，都是布满了上下贯通的用来放置铝管的孔位。二者间隔后按照在中心转轴33上整体呈蜂巢式结构。整个蜂巢式结构随着所述中心转轴33旋转，从而依次出现在操作窗口121位置，以备操作需要。
本实用新型进一步的实施方式，所述上蜂巢存储板31与所述下蜂巢存储板32的周向边缘通过均匀分布的多个支撑件34固定连接；
所述上蜂巢存储板31的上周边部设有转动内齿圈351，与所述存储罐罐体11外部的旋转驱动件36通过齿轮352啮合连接。
支撑件34加强了蜂巢式结构的整体稳固性。所述旋转驱动件36可以是驱动电机，通过与驱动电机同轴连接的齿轮352与上蜂巢存储板31的转动内齿圈351啮合连接，实现了驱动电机直接驱动蜂巢式结构转动的目的，这种传动方式提高了转动精度，实现了更加精准的转动挑选需要的冻存管。
本实用新型进一步的实施方式，所述支撑件34为中空结构的支撑杆，其两端分别开设有导冷进气口和导冷出气口。
中空结构的支撑杆，在连接所述上蜂巢存储板31与所述下蜂巢存储板32的同时，还利用其上的导冷进气口和导冷出气口进行液氮传导，增强了旋转存储机构3内部的持续保冷功能，也利于液氮的向上传输。
本实用新型进一步的实施方式，所述上蜂巢存储板31的外周通过导向结构37与所述存储罐罐体11可滑动连接。
导向结构37的设置，进一步提高了实现所述旋转存储机构3转动的传动过程稳定、可靠。
本实用新型进一步的实施方式，所述导向结构37包括固定连接在所述上蜂巢存储板31外周的环形导轨371以及固定连接所述存储罐罐体11内壁四周的若干个导向活动块372，所述导向活动块372滑动安装在所述环形导轨371上。
所述存储罐罐体11与所述旋转存储机构3具体通过导向活动块372和环形导轨371组成的滑动结构，实现了相对环向滑动。
本实用新型进一步的实施方式，所述固定操作机构2包括在所述旋转存储机构3的转动方向上依次并列布置的导板21和板架22，所述导板21上设有用于提取出冻存管的挑管孔211，所述板架22用于进行冻存管挑管。
导板21和板架22共同位于操作窗口121位置，为了全覆盖，导板21也需与所述旋转存储机构3的回转单元重叠，导板21主要用于将铝管内冻存管挑管放入板架22内，然后在板架22中进行调整到需要的冻存管。
本实用新型进一步的实施方式，所述板架22上还设有温度传感器221，用于检测板架22存放在导板21上的温度。便于进一步智能调控关联用。
本实用新型进一步的实施方式，所述固定操作机构2通过固定板23连接在所述存储罐罐体11的横截面径向位置，并靠近所述旋转存储机构3的顶部布置，所述固定板23上开设有贯通排氮口231。
固定板23在实现所述固定操作机构2的安装需要，同时利用贯通排氮口231保证液氮的有效流动，这里贯通排氮口231可以是设置在安装部位之间的 扇形缺口，也可以是设置在安装部位上的条形贯通孔，又或者同时采用。
本实用新型进一步的实施方式，所述液氮保冷机构4包括中心内筒体41，所述中心转轴33可转动的设置在所述中心内筒体41上部，所述中心内筒体41的上下端分别设有喷氮口411和进液管。
首先液氮由外部通过进液管412进入到中心内筒体41内，在中心内筒体41内存储一定量的液氮，并同时从喷氮口411持续向所述存储罐罐体11内排氮，达到持续保冷的目的。
最后应说明的是：以上实施例仅用以说明本实用新型的技术方案，而非对其限制；尽管参照前述实施例对本实用新型进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本实用新型各实施例技术方案的精神和范围。

Claims (15)

  1. 一种生物样本蜂巢式存储罐，包括由存储罐罐体和存储罐盖体组成的存储罐本体，其特征在于，所述存储罐罐体内部由上到下依次设有固定操作机构、旋转存储机构及液氮保冷机构；
    所述固定操作机构设置在所述存储罐盖体上开设的操作窗口下方，用于在所述存储罐罐体内部进行冻存管的提取和或挑管操作；
    所述旋转存储机构用于放置存放有冻存管的铝管并可将待提取和或挑管操作的铝管带动至所述固定操作机构下方；
    所述液氮保冷机构用于存储液氮并从存储罐罐体底部持续对所述固定操作机构、旋转存储机构进行保冷。
  2. 根据权利要求1所述的一种生物样本蜂巢式存储罐，其特征在于，所述存储罐罐体的侧壁及底壁均设有真空腔室，所述存储罐罐体的外部还设置有真空夹层的外壳。
  3. 根据权利要求2所述的一种生物样本蜂巢式存储罐，其特征在于，所述操作窗口处设有可拆卸的挡盖。
  4. 根据权利要求3所述的一种生物样本蜂巢式存储罐，其特征在于，所述操作窗口及挡盖均呈长条型，与所述旋转存储机构的回转单元重叠。
  5. 根据权利要求4所述的一种生物样本蜂巢式存储罐，其特征在于，所述挡盖的上部设有提取部，可与存储罐本体外部的机械臂配合连接以开合挡盖。
  6. 根据权利要求1或2或3或4或5所述的一种生物样本蜂巢式存储罐，其特征在于，所述存储罐盖体与所述旋转存储机构之间避开所述固定操作机构的区域还填充有保温结构。
  7. 根据权利要求1所述的一种生物样本蜂巢式存储罐，其特征在于，所述旋转存储机构包括上蜂巢存储板、下蜂巢存储板及中心转轴，所述上蜂巢存储板和下蜂巢存储板上下间隔布置于所述中心转轴上形成存储铝管的蜂巢式结构，二者的中间位置均与所述中心转轴转动连接。
  8. 根据权利要求7所述的一种生物样本蜂巢式存储罐，其特征在于，所述上蜂巢存储板与所述下蜂巢存储板的周向边缘通过均匀分布的多个支撑件固定连接；
    所述上蜂巢存储板的上周边部设有转动内齿圈，与所述存储罐罐体外部的旋转驱动件通过齿轮啮合连接。
  9. 根据权利要求8所述的一种生物样本蜂巢式存储罐，其特征在于，所述支撑件为中空结构的支撑杆，其两端分别开设有导冷进气口和导冷出气口。
  10. 根据权利要求7所述的一种生物样本蜂巢式存储罐，其特征在于，所述上蜂巢存储板的外周通过导向结构与所述存储罐罐体可滑动连接。
  11. 根据权利要求10所述的一种生物样本蜂巢式存储罐，其特征在于，所述导向结构包括固定连接在所述上蜂巢存储板外周的环形导轨以及固定连接所述存储罐罐体内壁四周的若干个导向活动块，所述导向活动块滑动安装在所述环形导轨上。
  12. 根据权利要求1或2或3或4或5或7或8或9或10或11所述的一种生物样本蜂巢式存储罐，其特征在于，所述固定操作机构包括在所述旋转存储机构的转动方向上依次并列布置的导板和板架，所述导板上设有用于提取出冻存管的挑管孔，所述板架用于进行冻存管挑管。
  13. 根据权利要求12所述的一种生物样本蜂巢式存储罐，其特征在于，所述板架上还设有温度传感器，用于检测板架存放在导板上的温度。
  14. 根据权利要求12所述的一种生物样本蜂巢式存储罐，其特征在于，所述固定操作机构通过固定板连接在所述存储罐罐体的横截面径向位置，并靠近所述旋转存储机构的顶部布置，所述固定板上开设有贯通排氮口。
  15. 根据权利要求7或8或9或10或11所述的一种生物样本蜂巢式存储罐，其特征在于，所述液氮保冷机构包括中心内筒体，所述中心转轴可转动的设置在所述中心内筒体上部，所述中心内筒体的上下端分别设有喷氮口和进液管。
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CN213801097U (zh) * 2020-09-30 2021-07-27 上海原能细胞生物低温设备有限公司 一种罐体转动开盖存储装置
CN215862857U (zh) * 2020-10-09 2022-02-18 南阳杜尔气体装备有限公司 一种改进型液氮储存罐
CN214877250U (zh) * 2021-05-11 2021-11-26 上海原能细胞生物低温设备有限公司 一种样本储存罐
CN113501247A (zh) * 2021-08-26 2021-10-15 义乌市铂玥信息技术咨询有限公司 转笼式超低温生物样本自动化存取系统
CN114394325A (zh) * 2022-02-17 2022-04-26 华威特（江苏）生物制药有限公司 一种疫苗存放设备
CN217893669U (zh) * 2022-07-13 2022-11-25 上海原能细胞生物低温设备有限公司 一种生物样本蜂巢式存储罐

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