WO2023216238A1 - Composition et son utilisation, et matériaux la comprenant - Google Patents

Composition et son utilisation, et matériaux la comprenant Download PDF

Info

Publication number
WO2023216238A1
WO2023216238A1 PCT/CN2022/092725 CN2022092725W WO2023216238A1 WO 2023216238 A1 WO2023216238 A1 WO 2023216238A1 CN 2022092725 W CN2022092725 W CN 2022092725W WO 2023216238 A1 WO2023216238 A1 WO 2023216238A1
Authority
WO
WIPO (PCT)
Prior art keywords
weight
composition
mask
present
disinfectant
Prior art date
Application number
PCT/CN2022/092725
Other languages
English (en)
Chinese (zh)
Inventor
李平
黄亦成
卜书红
杨玲
孙朝荣
胡燕锋
杜毅
张健
Original Assignee
李平
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 李平 filed Critical 李平
Priority to PCT/CN2022/092725 priority Critical patent/WO2023216238A1/fr
Publication of WO2023216238A1 publication Critical patent/WO2023216238A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/02—Layered materials
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/04—Materials specially adapted for outerwear characterised by special function or use
    • A41D31/12—Hygroscopic; Water retaining
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/04—Materials specially adapted for outerwear characterised by special function or use
    • A41D31/14—Air permeable, i.e. capable of being penetrated by gases
    • A—HUMAN NECESSITIES
    • A62—LIFE-SAVING; FIRE-FIGHTING
    • A62D—CHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING OR PROTECTING AGAINST HARMFUL CHEMICAL AGENTS; CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS
    • A62D3/00—Processes for making harmful chemical substances harmless or less harmful, by effecting a chemical change in the substances
    • A62D3/02—Processes for making harmful chemical substances harmless or less harmful, by effecting a chemical change in the substances by biological methods, i.e. processes using enzymes or microorganisms
    • A—HUMAN NECESSITIES
    • A62—LIFE-SAVING; FIRE-FIGHTING
    • A62D—CHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING OR PROTECTING AGAINST HARMFUL CHEMICAL AGENTS; CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS
    • A62D9/00—Composition of chemical substances for use in breathing apparatus

Definitions

  • the present invention relates to the field of material technology, and in particular to a composition that adsorbs and neutralizes volatile gases of disinfectants, its use, and materials containing the same.
  • High-efficiency disinfectants refer to disinfectants that can kill various microorganisms (including bacterial spores).
  • Currently widely used disinfectants include chlorine-containing disinfectants (such as chloroisocyanuric acid disinfectant tablets, 84 disinfectant, bleaching powder, sodium hypochlorite, Chloric acid air disinfectant, liquid chlorine, and new chlorine dioxide, etc.), peroxide disinfectants (such as peracetic acid, hydrogen peroxide), aldehyde disinfectants, ethylene oxide, etc.
  • chlorine-containing disinfectants and peroxide disinfectants are oxidizing disinfectants, also known as high redox potential disinfectants, which have broad-spectrum and efficient killing of microorganisms.
  • this type of high-efficiency disinfectant is much more oxidative, corrosive, irritating, and allergenic to mucous membrane tissues such as skin, respiratory tract, and eyes than conventional medical skin and mucous membrane disinfectants such as iodine, benzalkonium bromide, and chlorhexidine.
  • There have been reports of adverse reactions and physical damage to epidemic prevention personnel after being exposed to chlorine-containing disinfectants reports of occupational asthma caused by peracetic acid, and reports of people accidentally taking peracetic acid disinfectant and chlorine dioxide disinfectant tablets. Reports of poisonings. Therefore, the occupational exposure injuries of high-efficiency disinfectants and the rescue of accidental poisoning are issues involving the safety of global anti-epidemic chemicals.
  • CN 2109208U discloses an anti-virus and anti-bacteria activated carbon fiber with strong adsorption force, which enables it to have efficient adsorption capacity and anti-toxic effect on harmful gases such as benzene, sulfur dioxide, chlorine, ammonia and bacteria, as well as bacteria.
  • activated carbon usually needs to be in contact with tap water for more than 2 minutes to fully adsorb residual chlorine in tap water.
  • the time it takes for volatile chlorine to pass through the mask is only a few milliseconds.
  • the thin activated carbon fiber layer does not have time to capture inorganic small molecule gases such as chlorine. Only professional canisters or cartridges can filter them out. Therefore, activated carbon masks are mainly used to adsorb organic vapor and particulate matter with larger molecular volumes.
  • CN 111394728A discloses a further treatment method for chlorine gas in an acid etching copper recovery system.
  • the chlorine gas and the etching liquid are mixed with gas and liquid, and then sent into the first-stage iron absorption tank to react with metallic iron to produce ferric chloride.
  • this technology is not suitable for use on masks because reduced iron powder is likely to be inhaled into the lungs, causing diseases similar to pulmonary hemosiderosis.
  • CN 111330419A discloses a method for jointly absorbing chlorine gas using water and sodium hydroxide (liquid alkali).
  • this technology is not suitable for use on masks. Alkaline substances may cause serious damage to facial skin and respiratory tract.
  • the "Technical Specifications for Disinfectants” discloses a technical solution for using sodium thiosulfate to neutralize chlorine-containing disinfectants and peroxide disinfectants.
  • Sodium thiosulfate is a weakly alkaline and strongly reducing substance that is basically not absorbed when taken orally and can neutralize the acidity and oxidation of oxidizing disinfectants.
  • the irritation of this substance to the respiratory mucosa is unknown, and there is no safety study on airway inhalation of this strongly reducing inorganic substance.
  • sodium thiosulfate may produce elemental sulfur particles under the action of weak oxidants, such as Cl 2 +Na 2 S 2 O 3 +H 2 O ⁇ 2NaCl+S ⁇ +H 2 SO 4 .
  • This kind of new elemental sulfur particles are tiny and are inhalable particles. They may have adverse effects on lung tissue, so they are not suitable for use in masks involving respiratory protection.
  • the "Expert Consensus on Health Emergency Rescue and Clinical Treatment at the Site of Sudden Mass Chlorine Gas Leak Accident (2017)" further pointed out that there is currently no specific antidote for chlorine gas poisoning.
  • the present invention relates to a composition characterized by comprising, based on the total weight of the composition,: (A) about 0.1-99% by weight of biosorbent and (B) about 0.0001-99% % by weight of moisture attractant.
  • the biosorbent is selected from one or more of the following: (a) compounds containing enol structures; (b) compounds containing sulfhydryl groups; (c) amino acids; (d) biological enzymes.
  • the moisture-absorbing agent is selected from the group consisting of diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, glycerol polyether, xylitol, sorbitol, propylene glycol glucoside, and sodium lactate. and combinations thereof.
  • the composition further includes at least one of the following ingredients, based on the total weight of the composition: (e) about 0.00000001-1% by weight of a preservative; (f) about 0.00001-90% by weight of a preservative Acid-base buffer; (g) about 0.000001-5 wt% antioxidant; (h) about 0-1 wt% emulsifier; (i) about 0-20 wt% liquid sealant; (j) about 0 - 20% by weight of protein coagulant; (k) about 0-20% by weight of plant extract; (l) about 0.0001-2% by weight of odor masking agent.
  • the invention relates to an aqueous solution, characterized in that it contains the composition of the invention.
  • the composition is present in an amount of about 30-80% by weight, based on the total weight of the aqueous solution.
  • the invention in another aspect, relates to a substrate, characterized in that the substrate contains the composition of the invention, and the substrate is selected from the group consisting of non-woven cloth, metal mesh, glass fiber, cotton cloth, and linen cloth. and filter cotton, preferably non-woven fabric.
  • the present invention relates to a multi-layer material A, characterized in that the multi-layer material includes the base material of the present invention as a base material; and an activated carbon layer as the first filter layer.
  • a second filter layer is further included between the base material and the first filter layer.
  • the present invention relates to a multi-layer material B, characterized in that the multi-layer material includes the base material of the present invention as a first base material; an intermediate isolation layer including a porous breathable material that is not wetted by water. ;
  • the second base material includes biological enzymes, moisture absorbing agents, preservatives and acid-base buffers.
  • the invention relates to a mask, characterized in that the mask contains the base material or multi-layer material of the invention.
  • the present invention relates to a method for preparing a mask of the present invention, which includes: (1) providing a composition solution of the present invention; (2) spraying the composition liquid of step (1) onto The inside and/or outside of the mask.
  • Figure 1 shows the structural diagram of the mask A of the present invention
  • Figure 2 shows the structural diagram of the mask B of the present invention
  • Figure 3 shows the structural diagram of the mask C of the present invention
  • Figure 4 shows the structural diagram of the mask D of the present invention
  • Figure 5 shows the thermal imaging thermometer when wearing a disposable medical non-woven nursing mask or removing the above mask
  • Figure 6 shows the thermal image temperature measurement chart when wearing cotton or removing the above mask
  • Figure 7 shows the thermal image thermometry when wearing the mask A of the present invention or taking off the above mask
  • Figure 8 shows a spray bottle storing a solution of the composition of the present invention
  • Figure 9 shows a schematic diagram of using a spray bottle to prepare the mask of the present invention.
  • 101 represents the base material
  • 102 represents the ear hanging rope
  • 201 represents the activated carbon layer
  • 302 represents the middle isolation layer
  • 301 represents the second base material
  • 401 represents the base material
  • 1001 represents a transparent plastic bottle
  • 1002 Indicates the spray bottle button
  • 1003 indicates the nozzle
  • 1004 indicates the pipette
  • 1005 indicates the liquid sealant
  • 1006 indicates the composition solution.
  • selected from refers to one or more elements from the group listed thereafter, selected independently, and may include combinations of two or more elements.
  • one or more or “at least one” as used herein means one, two, three, four, five, six, seven, eight, nine or more.
  • the terms “optionally” or “optionally” mean that the subsequently described event or circumstance may or may not occur, and that the description includes both the occurrence and absence of the stated event or circumstance.
  • alkyl refers to a straight or branched saturated aliphatic hydrocarbon group consisting of carbon atoms and hydrogen atoms connected to the rest of the molecule by a single bond.
  • Alkyl may have 1-10 carbon atoms, that is, "C 1 -C 10 alkyl", such as C 1 -C 4 alkyl, C 1 -C 3 alkyl, C 1 -C 2 alkyl, C 3 alkyl, C 4 alkyl, C 3 -C 6 alkyl.
  • alkyl groups include, but are not limited to, methyl, ethyl, propyl, butyl, pentyl, hexyl, isopropyl, isobutyl, sec-butyl, tert-butyl, isopentyl, 2- Methylbutyl, 1-methylbutyl, 1-ethylpropyl, 1,2-dimethylpropyl, neopentyl, 1,1-dimethylpropyl, 4-methylpentyl, 3-methylpentyl, 2-methylpentyl, 1-methylpentyl, 2-ethylbutyl, 1-ethylbutyl, 3,3-dimethylbutyl, 2,2-di Methylbutyl, 1,1-dimethylbutyl, 2,3-dimethylbutyl, 1,3-dimethylbutyl or 1,2-dimethylbutyl, or their isomers body.
  • cycloalkyl when used herein alone or in combination with other groups, refers to a saturated, non-aromatic monocyclic or polycyclic (such as bicyclic) hydrocarbon ring (e.g., monocyclic, such as cyclopropyl, cyclobutyl , cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl; or bicyclic, including spiro, fused or bridged systems (such as bicyclo[1.1.1]pentyl, bicyclo[2.2.1] Heptyl, bicyclo[3.2.1]octyl or bicyclo[5.2.0]nonyl, decahydronaphthyl, etc.).
  • C 3-10 cycloalkyl refers to having 3-10 ring carbon atoms (such as 3, 4, 5, 6, 7, 8, 9 or 10) cycloalkyl groups.
  • 3-18 membered ring when used herein alone or in combination with other groups, refers to a ring containing 3-12 atoms. Such rings may be saturated or unsaturated (ie, contain one or more double or triple bonds).
  • “3-12-membered ring” can cover, for example, 3-6-membered, 6-9, 9-12, 12-15-membered and 15-18-membered rings, such as 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 or 18 membered rings.
  • 0, 1 or 2 additional heteroatoms may optionally be included in the carbocyclic ring. Examples of heteroatoms are oxygen, sulfur, and nitrogen.
  • 3-18 members in “3-18 membered ring” only refer to the number of carbon atoms therein. When additional heteroatoms are included, the number of heteroatoms is not counted in the number of ring atoms. For example, when it contains 1 heteroatom, a "3-18-membered ring" contains 4-19 ring atoms, of which 1 ring atom is a heteroatom and the rest are carbon atoms.
  • halo or "halogen” or “halo” is understood to mean a fluorine (F), chlorine (Cl), bromine (Br) or iodine (I) atom, preferably a fluorine, chlorine, bromine atom.
  • aryl refers to an all-carbon monocyclic or fused polycyclic (eg, bicyclic) aromatic ring group having a conjugated ⁇ electron system.
  • an aryl group may have 6-14 carbon atoms, suitably 6-10, more suitably 6 or 10.
  • Examples of aryl groups include, but are not limited to, phenyl, naphthyl, anthracenyl, and the like.
  • amino acid refers to an organic compound or moiety consisting of amino and carboxyl functional groups and attached side chains, such as amino acids and their stereoisomers with the following chemical formula: H 2 N-(CR a R b ) t CO 2 H; wherein, R a and R b are each independently hydrogen or any substituent, and t is an integer greater than or equal to 1, such as 1, 2, 3, 4 or 5. Substituents may be linear or branched structures.
  • R a and/or R b each independently correspond to, but are not limited to, hydrogen or side chains on naturally occurring amino acids, such as methyl, benzyl, hydroxymethyl, thiomethyl, carboxyl, carboxymethyl, Guanidinopropyl, etc.
  • Amino acids include naturally occurring amino acids, unnatural amino acids, imino acids such as proline, amino acid analogs, and amino acid mimetics that function in a manner similar to naturally occurring amino acids, and also include their D and L stereoisomers form.
  • Naturally encoded amino acids are protein amino acids known to those skilled in the art, including 20 common amino acids, namely alanine (Ala), arginine (Arg), asparagine (Asn), aspartic acid (Asp) ), cysteine (Cys), glutamine (Gln), glutamic acid (Glu), glycine (Gly), histidine (His), isoleucine (Ile), leucine (Leu) , Lysine (Lys), methionine (Met), phenylalanine (Phe), proline (Pro), serine (Ser), threonine (Thr), tryptophan (Trp), Tyrosine (Tyr) and valine (Val).
  • moisture attractant refers to an agent used to absorb moisture.
  • exemplary moisture attractants include, but are not limited to, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, glycerol polyethers, xylitol, sorbitol, propylene glycol glucoside, and sodium lactate.
  • acid-base buffer refers to a solution used to control the pH of a solution to keep the pH within a certain range.
  • exemplary acid-base buffers include, but are not limited to, citrate buffer, ammonium buffer, acetate buffer, phosphate buffer, and bicarbonate buffer.
  • porous breathable material refers to a material that contains internal porosity with interconnected pores to allow airflow through the material.
  • exemplary porous breathable materials include, but are not limited to, polyester filter wool, glass wool, rock wool, air filter cotton, and foam sponge.
  • oxidizing disinfectant refers to a disinfectant containing oxidizing active substances, wherein exemplary oxidizing active substances include but are not limited to chlorine, hydrogen peroxide, aldehydes, peracetic acid, etc.
  • the term "irritant gas” used herein refers to gases that are irritating to the eyes and respiratory mucosa, and are usually toxic gases commonly encountered in the chemical industry.
  • the irritating gas refers to the gas contained in the oxidative disinfectant, which includes but is not limited to chlorine, chlorine dioxide, hydrogen peroxide, aldehydes, peracetic acid, etc.
  • multilayer material A and multilayer material B used herein are only used to distinguish the above two multilayer materials containing different structures, but not in terms of nature, use or order.
  • first base layer material “second base layer material”, “first filter layer” and “second filter layer” used herein are only used to distinguish them from other layers in the multi-layer material, and do not indicate the nature or use of the materials. or order, etc.
  • the present invention relates to a composition for adsorbing and neutralizing irritating gases in an oxidative disinfectant, the composition comprising: (A) about 0.1-99 based on the total weight of the composition % by weight of biosorbent and (B) about 0.0001 to 99% by weight of moisture attractant.
  • the composition includes: (A) about 26-46 wt% biosorbent and (B) about 44-64 wt% moisture attractant, based on the total weight of the composition. In a preferred embodiment, the composition contains: (A) about 36 wt% biosorbent and (B) about 54 wt% moisture attractant, based on the total weight of the composition.
  • a biosorbent is a biological material capable of adsorbing and neutralizing irritating gases.
  • exemplary biosorbents include, but are not limited to, small molecule compounds, high molecular polymers, amino acids, proteins, enzymes, etc.
  • neutralizing irritating gases means that the biosorbent chemically reacts with the irritating gas to form environmentally friendly substances, or the biosorbent decomposes the irritating gas into environmentally friendly substances.
  • the biosorbent is selected from one or more of the following:
  • the enol structure refers to a chemical moiety with an alkene, which has a hydroxyl group attached to one end of the alkene double bond, and can be represented by the following chemical formula.
  • the substituents R 1 and R 2 are the same or different substituents, or they are connected to form a cyclic compound with an enol structure.
  • exemplary enol structure-containing compounds include, but are not limited to, vitamin C, vitamin B6, vitamin B9, catechol, vinyl alcohol, acetol, stigmastenol, tocotrienol, euphorbienol, isoenol, Ascorbic acid, ascorbyl palmitate, ascorbic acid glucoside, etc.
  • the compound containing an enol structure has reducing properties and can adsorb oxidative and irritating gases in the air and undergo redox reactions with them to form environmentally friendly products. It can remove oxidative and irritating gases in the environment without affecting the environment and human health.
  • some enol-containing compounds eg, vitamin C
  • vitamin C will change color, for example, yellow, after being oxidized. Therefore, compounds containing an enol structure can act as indicators. For example, when a compound containing an enol structure turns yellow, it can be known that the content of the active ingredient (the unoxidized compound containing an enol structure) is low. It helps to remind people to timely update the compounds containing enol structure used.
  • the compound containing an enol structure is a 3-18 membered cyclic enol compound containing 0, 1 or 2 additional heteroatoms independently selected from oxygen, sulfur, nitrogen and phosphorus and derivatives thereof substance, the ring may be optionally substituted by one or more substituents selected from the following, C 1-10 alkyl, C 3-10 cycloalkyl, aryl, aryl-C 1-4 alkyl, Wherein each alkyl, cycloalkyl, aryl group is unsubstituted or is independently selected from at least one group consisting of hydroxyl, CN, amino, acyl, carboxyl, halogen, C 1-10 alkyl, C 3-10 cycloalkyl , C 1-10 alkoxy substituent substituted.
  • the compound containing an enol structure is a 3-18 membered cyclic enol compound containing 0, 1 or 2 additional heteroatoms independently selected from oxygen, sulfur and nitrogen, and derivatives thereof substance, the ring may be optionally substituted by one or more substituents selected from the following, C 1-10 alkyl, aryl, wherein each alkyl, aryl is unsubstituted or is independently substituted by at least one Substituted with a substituent selected from hydroxyl, amino, acyl, carboxyl, halogen, C 1-10 alkyl; vinyl alcohol; acetol.
  • the compound containing an enol structure is selected from one or more of the following: vitamin C, vitamin B6, vitamin B9, catechol, vinyl alcohol, acetol, stigmasterene Alcohol, tocotrienol, euphorbienol, isoascorbic acid, ascorbyl palmitate, ascorbyl glucoside and its derivatives.
  • the compound containing an enol structure is selected from one or more of the following: vitamin C, vitamin B6, and vitamin B9.
  • the compound containing an enol structure is vitamin C.
  • the content of the enol structure-containing compound is about 0.01-95% by weight based on the total weight of the composition. In a preferred embodiment, the content of the enol structure-containing compound is about 1 to 50% by weight based on the total weight of the composition. In a more preferred embodiment, the content of the enol structure-containing compound is about 13.2-14.8% by weight based on the total weight of the composition. For example, about 13.2% by weight, about 13.3% by weight, about 13.4% by weight, about 13.5% by weight, about 13.6% by weight, about 13.7% by weight, about 13.8% by weight, about 14% by weight, about 14.2% by weight, about 14.4% by weight. , about 14.6% by weight, about 14.8% by weight.
  • the composition will produce a large amount of ketones and organic acid compounds after the redox reaction, which will increase the pH value of the composition system and make it easy to precipitate and crystallize at low temperatures. If the content of compounds containing an enol structure is too low, the oxidative irritating gases cannot be completely neutralized, and the discoloration of the mask is not obvious and it cannot function as an indicator.
  • Thiol refers to the -SH group.
  • the sulfhydryl group is reducing, so compounds containing sulfhydryl groups can be oxidized. Therefore, thiol-containing compounds can be used to adsorb oxidative and irritating gases in the air and undergo redox reactions with them to form environmentally friendly products. It can remove oxidative and irritating gases in the environment without affecting the polluted environment and human health.
  • mercapto compounds have a strong affinity for heavy metal ions (such as Cu 2+ , Pb 2+ , Ag +, etc.) (its affinity is much higher than that of ethylenediaminetetraacetic acid EDTA), allowing it to combine with the above heavy metal ions to form Metal sulfides precipitate, thereby removing heavy metal ions from the environment.
  • heavy metal ions such as Cu 2+ , Pb 2+ , Ag +, etc.
  • EDTA ethylenediaminetetraacetic acid
  • the thiol-containing compound is selected from the group consisting of cysteine, thioglycolic acid, dimercaprol, sodium dimercaprol, tiopronin, disodium dimercaptosulfate, cysteamine, penicillamine , lipoic acid, captopril, glutathione, alpha-lipoic acid, dithiothreitol and combinations thereof.
  • the thiol-containing compound is selected from the group consisting of N-acyl-cysteine, N-alkyl-cysteine, dimercaprol, disodium dimercapto, and dithiothreose Alcohols and their combinations.
  • the thiol-containing compound is selected from the group consisting of N-acetyl-L-cysteine, N-methyl-L-cysteine, N-ethyl-L-cysteine Acid, dimercaprol, disodium dimercapto, dithiothreitol and combinations thereof.
  • the thiol-containing compound is N-acetyl-L-cysteine.
  • the thiol-containing compound is present in an amount of about 0.0001 to 99% by weight, based on the total weight of the composition. In a preferred embodiment, the thiol-containing compound is present in an amount of about 0.1 to 20% by weight, based on the total weight of the composition. In a more preferred embodiment, the thiol-containing compound is present in an amount of about 3.0 to 3.4% by weight, based on the total weight of the composition. For example, about 3.0% by weight, about 3.02% by weight, about 3.06% by weight, about 3.1% by weight, about 3.12% by weight, about 3.16% by weight, about 3.20% by weight, about 3.23% by weight, about 3.26% by weight, about 3.28% by weight. , about 3.3% by weight, about 3.32% by weight, about 3.34% by weight, about 3.38% by weight, about 3.4% by weight. For example, about 1% by weight, about 1.125% by weight, and about 2.28% by weight.
  • sulfhydryl-containing compounds themselves have a special odor, such as a garlic-like sulfide odor, too high a content of sulfhydryl-containing compounds can easily irritate the eyes and respiratory mucosa and should not be used in production practice, such as in daily necessities.
  • An excessively low content of thiol-containing compounds makes the composition of the present invention insufficiently reducible, unable to adsorb and neutralize sufficient oxidative irritating gases, unable to reduce the activity of proteins, and is also unfavorable to the stability of compounds containing enol structures. .
  • the primary amino groups in amino acids can react with aldehydes to obtain Schiff base compounds. Therefore, adding amino acids to the composition of the present invention can effectively adsorb and neutralize aldehyde-based compounds in the air, thereby reducing the damage caused by aldehyde compounds to the human body.
  • the amino acid is selected from the group consisting of alanine, valine, leucine, isoleucine, methionine, proline, tryptophan, serine, tyrosine, cysteine Acid, phenylalanine, asparagine, glutamine, threonine, aspartic acid, glutamic acid, lysine, arginine, histidine, glycine and combinations thereof.
  • the amino acid is selected from the group consisting of glycine, glutamic acid and combinations thereof.
  • the amino acid is glycine.
  • the amino acid is present in an amount of about 0.0001-95% by weight, based on the total weight of the composition. In a preferred embodiment, the amino acid is present in an amount of about 0.0001 to 85% by weight, based on the total weight of the composition. In a more preferred embodiment, the amino acid is present in an amount of about 20-25% by weight, based on the total weight of the composition.
  • Bio enzymes refer to catalytic organic substances produced by living cells, which can specifically catalyze the transformation of substances. Different types of biological enzymes can be selected and used according to actual production or work purposes. For example, in order to absorb and break down hydrogen peroxide, catalase is used in the actual work process.
  • the biological enzyme is selected from the group consisting of catalase and horseradish peroxidase.
  • the biological enzyme is catalase.
  • An exemplary catalase may be food-grade catalase with a specification of 50,000 U/g.
  • the biological enzyme is present in an amount of about 0.0000001-20% by weight based on the total weight of the composition. In a preferred embodiment, the biological enzyme is present in an amount of about 0.02-0.2% by weight based on the total weight of the composition.
  • Too high or too low biological enzyme content will reduce the speed of hydrogen peroxide catalytic decomposition.
  • Hygroscopic agents are agents used to absorb moisture.
  • Exemplary moisture attractants include, but are not limited to, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, glycerol polyether, xylitol, sorbitol, propylene glycol glucoside, sodium lactate, and the like.
  • the hygroscopic agent in the composition of the present invention can absorb moisture in the air or additional added moisture, so that the composition becomes a moist or solution state, thereby dissolving the biosorbent in the moisture, thereby increasing the biosorbent
  • the contact area with the adsorbed gas (such as chlorine, hydrogen peroxide, peracetic acid, aldehyde compounds, etc.) improves the efficiency of gas adsorption.
  • the moisture attracting agent is selected from the group consisting of diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, glycerol polyether, xylitol, sorbitol, propylene glycol glucoside, and sodium lactate. and combinations thereof.
  • the moisture attractant is selected from the group consisting of glycerin, propylene glycol and combinations thereof.
  • the moisture attracting agent is glycerol.
  • the moisture attractant is present in an amount of about 0.0001-99% by weight. In a preferred embodiment, the moisture attractant is present in an amount of about 44 to 64% by weight. In a more preferred embodiment, the content of the moisture attractant is about 50-54% by weight, such as about 51% by weight, about 51.3% by weight, about 51.8% by weight, about 52% by weight, about 52.2% by weight, about 52.6% by weight. % by weight, about 53% by weight, about 53.5% by weight, about 53.8% by weight, about 54% by weight.
  • Excessively high moisture attractant content will cause the composition to absorb a large amount of water, causing a sudden increase in liquid volume, reducing the breathability of the composition, thereby increasing the breathability resistance of the composition.
  • a moisture absorbing agent when used in a protective mask, an excessively high moisture absorbing agent content will lead to a reduction in the breathability of the composition, thereby reducing the comfort of the protective mask.
  • an excessively high moisture-drawing agent content will increase the viscosity of the composition, making it difficult to atomize and spray the composition solution. Too low a moisture attractant content cannot form a sufficient aquifer to effectively absorb water-soluble irritating gases.
  • composition of the present invention also contains other components according to the needs of the actual situation and the optimal working environment required by the biosorbent.
  • the compositions of the present invention may include a preservative.
  • the composition of the present invention in order to make the biosorbent (such as amino acid) more susceptible to adsorbing aldehyde-based compounds, can include an acid-base buffer, wherein the acid-base buffer can adjust the working environment of the composition to be alkaline or alkaline. acidic.
  • the composition further includes at least one of the following ingredients, based on the total weight of the composition:
  • Preservatives refer to components that increase the stability of the compositions of the present invention.
  • the preservative is selected from the group consisting of parahydroxybenzoic acid preservatives (parabens), benzoic acid preservatives, sorbic acid preservatives, benzalkonium bromide, chlorhexidine acetate, ortho Phenylphenols, hexamethyleneguanidine hydrochloride preservative, dehydroacetic acid, sodium diacetate, polylysine, sodium lactate, natamycin.
  • the preservative is selected from paraben-based preservatives and sorbic acid-based preservatives.
  • the preservative is a paraben catalyst.
  • the preservative is ethylparaben (also known as ethylparaben).
  • adding a preservative to the composition of the present invention can improve the stability of the composition and inhibit the growth of microorganisms.
  • microorganisms that can inhibit growth include bacteria and fungi.
  • the bacteria may be, for example, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, hemolytic Streptococcus, etc.
  • the preservative is present in an amount of about 0.00000001-1% by weight, based on the total weight of the composition. In a preferred embodiment, the preservative is present in an amount of about 0.001 to 0.5% by weight, based on the total weight of the composition. In a more preferred embodiment, the preservative is present in an amount of about 0.05 to 0.3% by weight, based on the total weight of the composition. For example, about 0.05% by weight, about 0.1% by weight, about 0.15% by weight, about 0.2% by weight, 0.25% by weight, and about 0.3% by weight.
  • Acid-base buffer refers to a mixed solution composed of weak acid and its salts or weak base and its salts. It can offset and reduce the influence of external strong acid or strong base on the pH of the solution to a certain extent, thereby maintaining the pH value of the solution relatively Stablize.
  • different acid-base buffers are selected to provide a suitable working environment for the biosorbent and other components, improve the adsorption of the biosorbent and neutralize stimulation. Efficiency of sexual gas.
  • the acid-base buffer is selected from the group consisting of sodium bicarbonate buffer, phosphate buffer, sodium acetate, and sodium citrate buffer.
  • the acid-base buffer is selected from phosphate buffer.
  • the acid-base buffer is selected from sodium dihydrogen phosphate-disodium hydrogen phosphate buffer.
  • the acid-base buffer is sodium bicarbonate buffer.
  • the acid-base buffer used in the present invention can adjust the pH of the composition system to about 3-10. In a preferred embodiment, the acid-base buffer used in the present invention can adjust the pH of the composition system to about 5.0-6.2. In a more preferred embodiment, the acid-base buffer used in the present invention can adjust the pH of the composition system to about 5.8 (the average pH of the skin). A pH value that is too low is not conducive to the Schiff base reaction of amino acids and aldehyde compounds, and a pH value that is too high will cause the stability of compounds containing enol structures (such as vitamin C) to decrease.
  • enol structures such as vitamin C
  • the acid-base buffering agent is present in an amount of about 0.00001-90% by weight, based on the total weight of the composition. In a preferred embodiment, the acid-base buffering agent is present in an amount of about 0.01 to 5% by weight, based on the total weight of the composition. In a more preferred embodiment, the acid-base buffering agent is present in an amount of about 1.0-2.5% by weight, based on the total weight of the composition. For example, about 1.0% by weight, about 1.3% by weight, about 1.5% by weight, about 1.8% by weight, about 2.0% by weight, about 2.2% by weight, about 2.5% by weight.
  • Antioxidants are substances that can delay, reduce, inhibit or prevent the oxidation of oxidizable substances.
  • the biosorbent may be an enol structure-containing compound or a sulfhydryl group-containing compound with reducing properties. Therefore, in order to extend the storage time of the composition, antioxidants can be added to the composition to improve the durability of the composition.
  • the antioxidant is selected from the group consisting of sodium metabisulfite, sodium bisulfite, sodium thiosulfate, vitamin E, L-ascorbyl palmitate, alkyl gallate, butylated hydroxyanisole, and butylated hydroxytoluene.
  • the antioxidant is sodium metabisulfite.
  • the antioxidant is present in an amount of about 0.000001-5% by weight, based on the total weight of the composition. In a preferred embodiment, the antioxidant is present in an amount of about 0.001 to 0.04% by weight, based on the total weight of the composition. In a more preferred embodiment, the acid-base buffering agent is present in an amount of about 0.01 to 0.03% by weight, based on the total weight of the composition. For example, about 0.01% by weight, about 0.013% by weight, about 0.015% by weight, about 0.017% by weight, about 0.02% by weight, about 0.023% by weight, about 0.025% by weight, about 0.027% by weight, about 0.029% by weight, about 0.03% by weight. .
  • antioxidant content will exceed the upper limit of the amount of food additives, which is not conducive to the application of the composition of the present invention in daily necessities.
  • Antioxidant content that is too low is insufficient to prevent enol compounds from being oxidized.
  • Emulsifier refers to a class of compounds that can mix two or more mutually immiscible components to form a stable emulsion.
  • an organic compound such as ethyl hydroxyphenyl ester
  • its solubility in water is poor. Therefore, in order to improve the solubility of the preservative in water so that the composition of the present invention can have a longer shelf life, an emulsifier is added to the composition.
  • the emulsifier is selected from polysorbate, triethanolamine, sorbitan oleate (Span), alkylphenol polyoxyethylene ether (OP), glyceryl stearate, lauryl Sodium sulfonate.
  • the emulsifier is polysorbate.
  • the emulsifier is polysorbate-80 (Tween-80).
  • the emulsifier is present in an amount of from about 0 to 1% by weight, based on the total weight of the composition. In a preferred embodiment, the emulsifier is present in an amount of about 0.001 to 0.01% by weight, based on the total weight of the composition. For example, about 0.001% by weight, about 0.002% by weight, about 0.003% by weight, about 0.004% by weight, about 0.005% by weight, about 0.006% by weight, about 0.007% by weight, about 0.008% by weight, about 0.009% by weight, about 0.01% by weight. .
  • Excessive emulsifier content will affect the preservative effect of the preservative. Too low emulsifier content is not conducive to the dissolution of preservatives. For example, when the composition of the present invention is stored under low temperature conditions, the preservative may precipitate from the composition system, so the preservative cannot effectively play a preservative role.
  • the preservative used is a water-soluble preservative
  • no emulsifier may be added to the composition.
  • the composition of the present invention is easily in contact with air during storage and retrieval, forming an aqueous solution, and the compounds containing an enol structure and the compounds containing a thiol structure in the composition are easily oxidized by the air above the solution. Therefore, in order to reduce the losses caused by the above reasons to the composition and enhance the stability of the composition of the present invention, a liquid sealing agent is added to the solution of the composition to isolate the composition of the present invention from air.
  • the liquid sealing agent is selected from edible oil, mineral oil, silicone oil, dimethicone and liquid paraffin (paraffin oil). In a preferred embodiment, the liquid sealing agent is liquid paraffin.
  • the liquid sealant is present in an amount of about 0-20% by weight based on the total weight of the composition. In a preferred embodiment, the liquid sealant is present in an amount of about 1 to 10% by weight based on the total weight of the composition. For example, about 1% by weight, about 2% by weight, about 3% by weight, about 4% by weight, about 5% by weight, about 6% by weight, about 7% by weight, about 8% by weight, about 9% by weight, about 10% by weight. .
  • liquid sealant The purpose of using a liquid sealant is to prevent the composition from being oxidized by air when it is taken out when the composition is stored in a rigid container (such as a stainless steel barrel). Excessively high liquid sealing agent content will cause low-polarity substances in the composition (such as fat-soluble preservatives) to dissolve in the liquid sealing agent, affecting the performance of the composition. Too low a liquid sealant content will prevent the liquid sealant from completely covering the surface of the composition. When packaging materials with air-isolating functions (such as vacuum bottles and ampoules with a piston AS plastic at the bottom) are used for retail packaging, liquid sealing agent does not need to be added.
  • preservatives are only effective against microorganisms with cellular structures such as bacteria and fungi, but are not effective against microorganisms such as viruses that are composed of nucleic acid and protein shells. Therefore, adding a protein coagulant to the composition of the present invention can destroy the spatial conformation of the protein, prompting the protein shell of the virus to coagulate and lose biological activity, thereby possibly producing an antiviral effect.
  • the protein coagulant is selected from sodium sulfate, ammonium sulfate, picric acid, phosphotungstic acid, phosphomolybdic acid, tannic acid, trichloroacetic acid, sulfosalicylic acid, urea, berberine, Tetrandrine, guanidine hydrochloride, gluconic acid and its salts, glucono-delta-lactone and combinations thereof.
  • the protein coagulant is glucono-delta-lactone.
  • the protein coagulant is present in an amount of about 0-20% by weight, based on the total weight of the composition. In a preferred embodiment, the protein coagulant is present in an amount of about 0.0001 to 20% by weight, based on the total weight of the composition. In a more preferred embodiment, the protein coagulant is present in an amount of about 0.1-0.3% by weight, such as about 0.1% by weight, about 0.13% by weight, about 0.15% by weight, about 0.18% by weight, about 0.18% by weight, based on the total weight of the composition. 0.2% by weight, about 0.25% by weight, about 0.3% by weight.
  • Protein coagulant levels that are too low can reduce the bioactive ability of the antiviral protein coat of the composition.
  • lower-content protein coagulants are less irritating and can be used for respiratory aerosol inhalation.
  • compositions of the present invention may enhance the overall antimicrobial effectiveness of the compositions.
  • the main component molecules of the plant extract contain at least 4 hydroxyl groups, which are selected from the group consisting of chlorogenic acid, luteolin, luteolin, and luteolin-7-O- ⁇ -D- Glucuronide and a plant extract of one of the proanthocyanidin components.
  • the proanthocyanidin component can be selected from, for example, the leaves of Eucommia ulmoides, Lonicera japonica (honeysuckle), Lonicera erythricum, flowers of Honeysuckle or Lonicera tomentosa, Lonicera vine, and English hawthorn.
  • the plant extract is grape seed extract (the main component of which is proanthocyanidins).
  • the plant extract is present in an amount of about 0-20% by weight, based on the total weight of the composition. In a preferred embodiment, the plant extract is present in an amount of about 0.0001 to 20% by weight, based on the total weight of the composition. In a more preferred embodiment, the plant extract is present in an amount of about 0.5-0.9% by weight, based on the total weight of the composition. For example, about 0.5% by weight, about 0.6% by weight, about 0.7% by weight, about 0.8% by weight, and about 0.9% by weight.
  • Plant extracts are usually brown, ultraviolet-blue-violet light-absorbing substances that can act as sunscreens. Too high a content of plant extracts will make the composition too dark, thus affecting its aesthetics. Too low a content of plant extracts will reduce the light absorption properties of the composition, which is not conducive to the stable storage of compounds containing enol structures that are sensitive to light, and will result in weakened antimicrobial activity. However, reducing the content of plant extracts can reduce irritation, making it suitable for respiratory aerosol inhalation.
  • the odor masking agent may be a fruity flavor.
  • the odor masking agent is selected from volatile oils from tangerine peels of the family Rutaceae, such as lemon oil, whose main component is limonene, and its minor components also include pinene, myrcene, terpinene, etc.
  • lemon oil-containing botanicals such as tangerine peel, traditional Chinese medicine pieces
  • eucalyptus lemon and pinole enteric-coated soft capsules (National Drug Approval No. H20052401) can improve the ciliary movement of tracheal mucosa, promote the secretion of respiratory glands, reduce phlegm, and promote self-purification of the respiratory tract.
  • Pharmacological effects It is a classic auxiliary medicine for respiratory diseases.
  • the odor masking agent is present in an amount of about 0.0001-2% by weight, based on the total weight of the composition. In a preferred embodiment, the odor masking agent is present in an amount of about 0.01 to 0.9% by weight, based on the total weight of the composition. In a more preferred embodiment, the odor masking agent is present in an amount of about 0.2 to 0.5% by weight, based on the total weight of the composition. For example, about 0.2% by weight, about 0.3% by weight, about 0.4% by weight, and about 0.5% by weight.
  • composition of the present invention contains a relatively high concentration of compounds containing enol structures and compounds containing sulfhydryl groups, which can have a good protective effect on the above-mentioned polyphenols. Therefore, the combination of the composition of the present invention and the above-mentioned substances It also helps the above-mentioned substances to realize their commercial value.
  • the isoelectric point of the S protein of 2019-nCoV is 6.24
  • the isoelectric point of S1/S2/His is 4.41-5.87
  • the isoelectric point of the key binding protein of hACE2/His is 5.19-6.11 through protein models. (average pH 5.60).
  • the pH value of the composition of the present invention is set to 5.6-6.0 (preferably pH is 5.8). During use, the pH will gradually increase (when the composition is exposed to the air, the CO2 content will gradually decrease) , the pH of the composition will slowly rise to near the isoelectric point of the S protein, thereby precipitating the protein. Therefore, the composition of the present application may have the effect of inhibiting the activity of viral surface proteins.
  • sulfhydryl structure in sulfhydryl-containing compounds can also act on the disulfide bonds of proteins, thereby destroying the protein conformation and reducing the viscosity of sputum.
  • N-acetylcysteine aerosol inhalation has been regulated by European and Chinese drug regulators. Approved by the bureau for the treatment of phlegm (such as: acetylcysteine solution for inhalation, National Drug Approval H20150548, JX20020133, ZAMBON S.p.A.). Therefore, since the composition of the present invention contains a sulfhydryl compound, it can also achieve a long-lasting protein activity inhibition effect.
  • the invention relates to an aqueous solution, characterized in that it contains the composition of the invention.
  • the composition is present in an amount of about 30-80% by weight, based on the total weight of the aqueous solution. In a preferred embodiment, the composition is present in an amount of about 56-76% by weight, based on the total weight of the aqueous solution. In a more preferred embodiment, the composition is present in an amount of about 66% by weight, based on the total weight of the aqueous solution. For example, about 30% by weight, about 35% by weight, about 40% by weight, about 43% by weight, about 45% by weight, about 50% by weight, about 55% by weight, about 60% by weight, about 63% by weight, about 65% by weight. , about 66% by weight, about 67% by weight, about 70% by weight, about 76% by weight, about 75% by weight.
  • an appropriate water content is conducive to the composition of the present invention achieving its technical effects, such as adsorbing and neutralizing irritating gases in oxidizing disinfectants, purifying the air, inhibiting biological protein activity, etc.
  • Excessively high water content results in a low content of the composition, which is insufficient to achieve the technical effects of the present invention.
  • Too low water content is not conducive to the full dissolution of the components, so that each component of the composition cannot be fully contacted with the adsorbed gas, so it cannot effectively adsorb and neutralize the irritating gases in the oxidizing disinfectant, and is not conducive to other Realization of technical effects.
  • the composition aqueous solution of the present invention can absorb and neutralize irritating gases (such as irritating gases in oxidative disinfectants) more effectively, and the adsorption efficiency can be significantly improved.
  • the invention relates to a substrate, characterized in that it contains a composition of the invention.
  • the substrate is used to adsorb and neutralize irritating gases in oxidative disinfectants.
  • composition of the invention is adsorbed onto the substrate.
  • the base material of the present invention refers to a material product, such as sheet, metal plate, non-woven fabric, glass fiber, etc.
  • a material product such as sheet, metal plate, non-woven fabric, glass fiber, etc.
  • different materials can be attached to the surface of the substrate.
  • activated carbon can be attached to the surface of the substrate.
  • a weakly alkaline compound such as sodium bicarbonate
  • reducing compounds such as compounds containing enol structures or compounds containing thiol groups, may be attached to the surface of the substrate.
  • the substrate may be a metal mesh.
  • the base material can be a non-woven fabric in a mask or a filter membrane in a gas mask.
  • the substrate is selected from the group consisting of non-woven cloth, metal mesh, fiberglass, cotton cloth, linen cloth, and filter cotton.
  • the substrate is non-woven fabric.
  • the present invention relates to a multi-layer material A, characterized in that the multi-layer material A includes: the base material of the present invention as the base material; and the activated carbon layer as the first filter layer.
  • the base material as the base material is selected from non-woven cloth, metal mesh, glass fiber, cotton cloth, linen cloth, and filter cotton.
  • the substrate is non-woven fabric.
  • the base material is attached with the composition of the present invention and can be used to adsorb and neutralize irritating gases.
  • the irritating gases can be, for example, volatile gases in oxidizing disinfectants, such as chlorine in chlorine-containing disinfectants, The volatilized hydrogen peroxide in hydrogen peroxide disinfectants or the volatilized peracetic acid in peracetic acid-containing disinfectants.
  • the irritating gas may be an aldehyde-based compound volatilized in a disinfectant containing an aldehyde-based compound.
  • the multi-layer material A also includes an activated carbon layer as the first filter layer, where the activated carbon layer is used to adsorb peracetic acid, a volatile gas in the air, but does not have the effect of neutralizing peracetic acid.
  • the multi-layer material A of the present invention further includes a second filter layer between the base material and the first filter layer.
  • a second filter is also included between the base material of the multi-layer material A of the present invention and the first filter layer. layer.
  • the substrate may be a metal mesh.
  • the base material can be a non-woven fabric in a mask or a filter membrane in a gas mask.
  • the second filter layer is selected from the group consisting of non-woven cloth, metal mesh, glass fiber, cotton cloth, linen cloth, and filter cotton.
  • the second filter layer is non-woven fabric.
  • the second filter layer is melt-blown non-woven fabric.
  • the present invention relates to a multi-layer material B, characterized in that the multi-layer material B includes: the base material of the present invention as a first base material; an intermediate isolation layer; and a second base material.
  • the first base material is the base material of the present invention, wherein the base material is as defined above.
  • the middle isolation layer is composed of a porous breathable material that is not wetted by water, and is used to isolate the first base material and the second base material so that the two base materials can work in different environments.
  • the first base layer material and the second base layer material have different working environments, for example, the pH of the two is different.
  • the temperatures of the two are different.
  • the humidity of the two is different.
  • the middle isolation layer includes a porous breathable material that is not wetted by water.
  • the porous breathable material is selected from the group consisting of polyester filter cotton, glass wool, rock wool, air filter cotton, and foam sponge.
  • the porous breathable material is polyester filter cotton.
  • the porous breathable material is an ethylene vinyl acetate (EVA) breathable sponge.
  • the thickness of the intermediate isolation layer is about 0.1-15 mm. In a preferred embodiment, the thickness of the intermediate isolation layer is about 3 mm.
  • the second base material includes biological enzymes, moisture absorbing agents, preservatives, and acid-base buffers, wherein the types of biological enzymes, moisture absorbing agents, acid-base buffers, and second base materials are as defined above.
  • the biological enzyme is catalase.
  • catalase is used to adsorb and decompose the volatile gas hydrogen peroxide.
  • the biosorbent in the first base material and the catalase in the second base material need to work under different pH conditions, they can fully exert their respective adsorption and neutralization of irritating gases. Therefore, an intermediate isolation layer is provided between the first base material and the second base material, which can effectively isolate the components in the two materials.
  • the middle isolation layer uses a porous breathable material that is not wetted by water. Gas can still pass through the middle isolation layer smoothly and be further adsorbed and neutralized by the active ingredients in the second base material.
  • the present invention relates to a mask comprising the base material, multi-layer material A or multi-layer material B of the present invention, wherein the base material, multi-layer material A and multi-layer material B are as defined above.
  • the present invention also relates to a method for preparing the mask of the present invention, which includes the following steps:
  • step (3) Drying the base material obtained in step (2) under a protective gas atmosphere;
  • the types and contents of the active ingredients or other ingredients in the first base layer material, the second base layer material, the second filter layer, the first filter layer, and the intermediate isolation layer are as defined above.
  • the protective gas used in step (3) and step (5) is selected from nitrogen, helium, neon and carbon dioxide. In a preferred embodiment, the protective gas used in step (3) and step (5) is nitrogen.
  • the protective gases used in step (3) and step (6) may be the same or different.
  • the drying temperature in step (3) and step (6) is about 50-80°C or room temperature. In a preferred embodiment, the drying temperature in step (3) and step (6) is about 60°C.
  • the present invention also relates to a method for quickly preparing the mask of the present invention, which includes the following steps:
  • step (2) Spray the composition liquid of step (1) onto the inside and/or outside of the mask by spraying.
  • composition solution of step (1) is stored in a spray bottle as described in Figure 8.
  • step (2) the composition of step (1) is sprayed via a spray bottle as shown in FIG. 8, see FIG. 9 for the spraying process.
  • the composition spraying position is about 5-10 cm above the mask.
  • the volume of the composition solution sprayed in step (2) is about 3.2 mL.
  • spray the inner and outer sides of the mask about 15-20 times to complete the spraying of the composition solution.
  • the inner and outer sides of the mask are sprayed about 17-19 times to complete the spraying of the composition solution. For example, about 15 times, about 16 times, about 17 times, about 18 times, about 19 times, and about 20 times.
  • composition of the present invention The stability of the composition of the present invention and its ability to adsorb and neutralize irritating gases in oxidizing disinfectant solutions
  • composition of the present invention to adsorb and neutralize irritating gases in oxidizing disinfectant solutions
  • composition of the present invention to neutralize irritating gases in the oxidizing disinfectant solution is tested by the following method A.
  • the ability of the composition of the present invention to adsorb and neutralize irritating gases in oxidative disinfectants is determined by the method described above.
  • the adsorption of chlorine gas in the disinfectant by the composition of the present invention is determined by titration of the aqueous solution of the composition of the present invention with trichloroisocyanuric acid disinfectant, sodium hypochlorite disinfectant and chlorine dioxide disinfectant aqueous solution. and ability.
  • the ability of the composition of the present invention to adsorb and neutralize hydrogen peroxide in the disinfectant is determined by titration of an aqueous solution of the composition of the present invention with a hydrogen peroxide wash solution.
  • the adsorption and neutralization ability of the composition of the present invention on the peracetic acid in the disinfectant is determined by titration of the aqueous solution of the composition of the present invention with an oxyacetic acid disinfectant solution.
  • titration indicator when titrating chlorine-containing disinfectants, use chlorine test paper as a titration indicator.
  • chlorine test paper For another example, when titrating hydrogen peroxide disinfectant, use hydrogen peroxide test paper as a titration indicator.
  • hydrogen peroxide test paper For another example, when titrating peracetic acid disinfectant, use peracetic acid test paper as a titration indicator.
  • a secondary indicator is used in determining the titration end point.
  • chlorine test paper is used as an auxiliary indicator to help determine the titration endpoint of hydrogen peroxide and peracetic acid disinfectants.
  • the ability of the composition of the present invention to neutralize irritating gases in the oxidative disinfectant solution is tested by the following method A1.
  • composition aqueous solution of the present invention wherein the content of the active ingredient (enol structure-containing compound and/or thiol structure-containing compound and/or amino acid) in the composition aqueous solution is about 2-8% by weight;
  • step (3) Use the disinfectant solution obtained in step (1) to titrate 1 mL of the composition aqueous solution in step (2), and record the volume of disinfectant solution consumed at the end point of the titration.
  • the trichloroisocyanuric acid aqueous solution is prepared by the above method to perform a titration experiment. At the end point of the titration, the volume of the trichloroisocyanuric acid aqueous solution consumed by the titration is about 5-50 mL. In a preferred embodiment, the trichloroisocyanuric acid aqueous solution is prepared by the above method to perform a titration experiment. At the titration end point, the volume of the trichloroisocyanuric acid aqueous solution consumed by the titration is about 10-30 mL.
  • the sodium hypochlorite disinfectant aqueous solution is prepared by the above method to perform a titration experiment. At the titration end point, the volume of the sodium hypochlorite disinfectant aqueous solution consumed by the titration is about 5-50 mL. In a preferred embodiment, the sodium hypochlorite disinfectant aqueous solution is prepared by the above method for a titration experiment. At the end point of the titration, the volume of the sodium hypochlorite disinfectant aqueous solution consumed by the titration is about 10-30 mL.
  • a chlorine dioxide disinfectant aqueous solution is prepared by the above method to perform a titration experiment. At the end point of the titration, the volume of the chlorine dioxide disinfectant aqueous solution consumed by the titration is about 50-150 mL.
  • the sodium hypochlorite disinfectant aqueous solution is prepared by the above method for a titration experiment. At the end point of the titration, the volume of the sodium hypochlorite disinfectant aqueous solution consumed by the titration is about 70-130 mL.
  • the hydrogen peroxide wash solution is prepared by the above method to perform a titration experiment. At the end point of the titration, the volume of hydrogen peroxide wash solution consumed by the titration is about 0.08-1 mL. In a preferred embodiment, the hydrogen peroxide wash solution is prepared by the above method to perform a titration experiment. At the end point of the titration, the volume of hydrogen peroxide wash solution consumed by the titration is about 0.08-0.5 mL.
  • the peracetic acid disinfectant solution is prepared by the above method for a titration experiment. At the end point of the titration, the volume of the peracetic acid disinfectant solution consumed by the titration is about 0.4-2.5 mL. In a preferred embodiment, the peracetic acid disinfectant solution is prepared by the above method for a titration experiment. At the end point of the titration, the volume of the peracetic acid disinfectant solution consumed by the titration is about 0.4-2.0 mL.
  • the glutaraldehyde disinfectant solution is prepared by the above method to perform a titration experiment. At the end point of the titration, the volume of the glutaraldehyde disinfectant solution consumed by the titration is about 3-5 mL. In a preferred embodiment, the glutaraldehyde disinfectant solution is prepared through the above method for a titration experiment. At the end point of the titration, the volume of peracetic acid disinfectant solution consumed by the titration is about 3.5-4.5 mL.
  • composition of the present invention is tested by the following method.
  • step (3) Use the disinfectant aqueous solution of step (1) to titrate the composition aqueous solution of step (2), and record the volume C 0 of the disinfectant aqueous solution consumed at the end point of the titration;
  • step (1) Store the aqueous composition solution of step (1) in a closed space at a constant temperature for a period of time;
  • step (1) Use the disinfectant aqueous solution of step (1) to titrate the composition aqueous solution of step (4), and record the volume C of the disinfectant aqueous solution consumed at the end point of the titration;
  • k represents the rate constant (d -1 )
  • C 0 represents the initial concentration
  • C represents the concentration at t
  • t-time is days (d)
  • t 1/2 represents the half-life.
  • composition of the invention is tested by the following method:
  • composition aqueous solution of the present invention wherein the content of the active ingredient (enol structure-containing compound and/or thiol structure-containing compound and/or amino acid) in the composition aqueous solution is about 2-3% by weight;
  • step (3) Use the disinfectant solution obtained in step (1) to titrate 1 mL of the aqueous composition solution of step (2), and record the volume C 0 of the disinfectant solution consumed at the end point of the titration;
  • step (2) Store the aqueous composition solution of step (2) in a room temperature space (such as an indoor room with a north-facing window, no direct sunlight, but with natural light and fluorescent indoor lighting) for about 60-365 days.
  • a room temperature space such as an indoor room with a north-facing window, no direct sunlight, but with natural light and fluorescent indoor lighting
  • step (1) Use the disinfectant solution obtained in step (1) to titrate 1 mL of the aqueous composition solution of step (4), and record the volume C of the disinfectant solution consumed at the end point of the titration;
  • an aqueous solution of trichloroisocyanuric acid is prepared by the above method and subjected to a titration experiment. After calculation, the half-life of the composition of the present invention is approximately 360-3600 days. In a preferred embodiment, an aqueous solution of trichloroisocyanuric acid is prepared by the above method and subjected to a titration experiment. After calculation, the half-life of the composition of the present invention is approximately 361-3300 days. For example, 365 days, 443 days, 443 days, 682 days, 1000 days, 2000 days, 3000 days, 3253 days.
  • compositions of the present invention are used to adsorb and neutralize irritating gases.
  • WHO recommends disinfectants containing ethanol or isopropyl alcohol as the main ingredient (i.e., alcohol-based disinfectants) for skin disinfection.
  • alcohol-based disinfectants i.e., ethanol or isopropyl alcohol as the main ingredient
  • the present invention designs relevant tests to test the compatibility of the composition with alcohol-based disinfectants.
  • the disinfection effect of the composition of the present invention and its compatibility with alcohol-based disinfectants were tested by the following method.
  • step (3) Shake the container in step (3) for 5 minutes, and then observe the protein denaturation and precipitation effect.
  • the pH of Composition 1 as well as Composition 2 is about 5.5-6.2.
  • composition 2 or the combination of composition 2 and disinfecting alcohol when added in step (2), the effect of protein denaturation and precipitation can be observed.
  • the ability of the mask of the present invention to neutralize irritating gases in the oxidative disinfectant solution is tested through the following two methods, namely qualitative testing and quantitative testing.
  • step (3) Place the disinfectant aqueous solution of step (2) in a closed container, and shake the container to fill the container with volatile irritating gas;
  • the disinfectant aqueous solution configured in step (2) of method B and step (3) of method C is selected from the group consisting of chlorine-containing disinfectant aqueous solution, hydrogen peroxide wash solution, peracetic acid disinfectant solution, and chlorine dioxide disinfection and glutaraldehyde disinfectant.
  • the chlorine-containing disinfectant aqueous solution is selected from the group consisting of trichloroisonitrile uric acid disinfectant solution and sodium hypochlorite disinfectant solution.
  • the concentration of the disinfectant aqueous solution configured in step (2) of method B and step (3) of method C is selected from the group consisting of 1000ppm, 30000ppm, 5000ppm, 100ppm and 20000ppm.
  • the disinfectant aqueous solution configured in step (2) of method B and step (3) of method C includes 1000 ppm chlorine-containing disinfectant solution, 30000 ppm hydrogen peroxide wash solution, 5000 ppm peracetic acid disinfectant solution, 100ppm chlorine dioxide disinfectant and 20000ppm glutaraldehyde disinfectant.
  • the closed container used in Method B is a 100 ml iodine flask.
  • the amount of disinfectant used is about 5-10 mL.
  • the amount of disinfectant used is about 5-10 mL.
  • the test paper used in Method C is selected from the group consisting of chlorine test paper, chlorine dioxide test paper and glutaraldehyde test paper.
  • the test paper used in method B is chlorine test paper
  • the test paper used in method C is chlorine dioxide test paper
  • glutaraldehyde disinfectant the test paper used in method C is glutaraldehyde test paper.
  • the distance between the two pieces of detection test paper is 3-5 mm to facilitate the passage of airflow.
  • the tester before wearing the mask of the present invention, can smell a strong irritating smell in the closed container; after wearing the mask of the present invention, the tester can smell the smell in about 2- No pungent odor can be smelled in the closed container within 5 minutes.
  • the detection is only carried out by method C.
  • test paper changes color on the outside of the mask of the present invention, but does not change color on the inside of the mask of the present invention.
  • step (2) Dissolve the mask in step (1) in water to obtain a mask extract
  • step (3) Use the disinfectant aqueous solution from step (3) to titrate the mask extract from step (2), and record the disinfectant aqueous solution consumed at the end point of the titration.
  • the ability of the mask of the present invention to neutralize irritating gases in the oxidative disinfectant solution is quantitatively tested by the following method D1:
  • step (2) Dissolve the mask in step (1) in 100 mL of water to obtain the mask extract;
  • step (2) Take 10 mL of the mask extract from step (2), titrate the mask extract with the disinfectant aqueous solution from step (3), and record the disinfectant aqueous solution consumed at the end point of the titration;
  • step (4) Amplify the titration result of step (4) 10 times to obtain the mask's ability to neutralize irritating gases in the oxidizing disinfectant solution.
  • the titration indicator is selected as described in Method A.
  • the mask of the present invention may contain liquid in an amount of about 3-4 mL.
  • liquid in an amount of about 3-4 mL.
  • the mask extract of the present invention is titrated by the above method. At the end point of the titration, the volume of the trichloroisocyanuric acid aqueous solution consumed is about 90-100 mL.
  • the mask extract of the present invention is titrated by the above method, and at the end point of the titration, the volume of hydrogen peroxide wash solution consumed is about 1-2 mL.
  • the mask extract of the present invention is titrated by the above method, and at the end point of the titration, the volume of peracetic acid disinfectant consumed is about 8-10 mL.
  • the mask extract of the present invention is titrated by the above method.
  • the volume of the consumed chlorine dioxide disinfectant aqueous solution is about 350-450 mL.
  • the mask extract of the present invention is titrated by the above method, and at the end point of the titration, the volume of glutaraldehyde disinfectant solution consumed is about 10-15 mL.
  • the stability of the mask of the present invention is tested through the following three methods, including qualitative testing, quantitative testing and microbial content determination.
  • the stability of the mask of the present invention was qualitatively tested by the following methods E and F.
  • step (1) Place the mask in step (1) in an environment with a relative humidity of 70-95% and a temperature of 25-35°C for 14 days;
  • step (3) The tester wears the mask obtained in step (3) for 30 minutes;
  • step (1) Place the mask in step (1) in an environment with a relative humidity of 70-95% and a temperature of 25-35°C for 14 days;
  • step (3) The tester wears the mask obtained in step (3) for 30 minutes;
  • the disinfectant solution, the concentration of the disinfectant solution, and the amount of the disinfectant solution used in Methods E and F are as described above.
  • the tester before wearing the mask of the present invention, can smell a strong pungent odor in the closed container; after wearing the mask of the present invention, the tester can smell a weak smell The smell of disinfectant is non-irritating.
  • test paper changes color on the outside of the mask of the present invention, but does not change color on the inside of the mask of the present invention.
  • the stability of the mask of the present invention is tested by the following method G.
  • step (1) Place the mask in step (1) in an environment with a relative humidity of 70-95% and a temperature of 25-35°C for 14 days;
  • the titration indicator is selected as described in Method A.
  • the mask extract of the present invention is titrated by the above method. At the end point of the titration, the volume of the trichloroisocyanuric acid aqueous solution consumed is about 30-40 mL.
  • the mask extract of the present invention is titrated by the above method, and at the end point of the titration, the volume of hydrogen peroxide wash solution consumed is about 0.3-0.4 mL.
  • the mask extract of the present invention is titrated by the above method. At the end point of the titration, the volume of peracetic acid disinfectant consumed is about 3-4 mL.
  • the mask extract of the present invention is titrated by the above method.
  • the volume of the consumed chlorine dioxide disinfectant aqueous solution is about 170-180 mL.
  • the mask extract of the present invention is titrated by the above method. At the end point of the titration, the volume of glutaraldehyde disinfectant solution consumed is about 10-12 mL.
  • the stability of the mask of the present invention is tested by the following method H.
  • the detected flora species include bacteria, fungi, and the like.
  • Exemplary bacteria can be, for example, coliforms, Pseudomonas aeruginosa, Staphylococcus aureus, hemolytic Streptococcus, etc.
  • the mask extract of the present invention is detected by the above method. After 14 days, the number of coliform bacteria is 0.
  • the mask extract of the present invention is detected by the above method. After 14 days, the number of Pseudomonas aeruginosa bacterial colonies is 0.
  • the mask extract of the present invention is detected by the above method. After 14 days, the number of Staphylococcus aureus colonies is 0.
  • the mask extract of the present invention is detected by the above method. After 14 days, the number of hemolytic streptococci is 0.
  • the mask extract of the present invention is detected by the above method. After 14 days, the number of fungal colonies is 0.
  • the mask extract of the present invention is tested by the above method. After 14 days, the total number of bacterial colonies is 250 CFU/g, wherein the bacteria are non-pathogenic Paenibacillus urinae.
  • the color development ability of the mask of the present invention is tested by the following method I.
  • the above-mentioned method I is used to simulate the scenario of the mask of the present invention after repeated use.
  • the method of heating the mask in Method 1 is fumigation, and the fumigation temperature is about 40-94°C.
  • the method of heating the mask in Method 1 is fumigation, and the fumigation time is about 2-6 hours. In a preferred embodiment, after heating and fumigation, it is continued to be placed in a residual heat environment for about 16-18 hours.
  • the type and concentration of the disinfectant solution are as described in methods B and C above.
  • the mask of the present invention will turn red after passing through the gas environment of high-concentration chlorine-containing disinfectant (such as hypochlorous acid disinfectant, chlorine dioxide disinfectant).
  • high-concentration chlorine-containing disinfectant such as hypochlorous acid disinfectant, chlorine dioxide disinfectant.
  • the mask of the present invention will turn into deep yellow after passing through the gas environment of high-concentration peroxide disinfectant.
  • the mask of the present invention after passing through the gas environment of high-concentration glutaraldehyde disinfectant solution, the mask of the present invention will turn into dark brown.
  • step (3) of method 1 before heating in step (3) of method 1, the following steps are also included:
  • the detection test paper is selected as described in method C above.
  • test paper on the inside of the mask of the present invention does not change color.
  • test paper on the inside of the mask of the present invention slightly changes color.
  • test paper on the inner side of the mask of the present invention after passing through the gas environment of high-concentration peracetic acid disinfectant solution, partially changes color.
  • test paper on the inside of the mask of the present invention does not change color.
  • test paper on the inside of the mask of the present invention does not change color.
  • the heat dissipation ability of the mask of the present invention is tested by the following method J.
  • the tester wears a mask and takes a thermal image temperature measurement
  • the tester takes off the mask and takes a thermal image temperature measurement.
  • the temperature of the area of the mask of the present invention that contacts the skin is about 2-3°C lower than the area below the nostrils that does not contact the skin. For example, about 2°C, about 2.2°C, about 2.4°C, about 2.6°C, about 2.8°C, and about 3°C.
  • the composition of the present invention uses a biosorbent and a hygroscopic agent. Through the adsorption effect of the hygroscopic agent on water, the composition becomes a moist or solution state, thereby increasing the contact area between the active ingredient biosorbent and irritating gases. , effectively improve the efficiency of adsorbing and neutralizing irritating gases, and can effectively reduce the concentration of certain irritating gases in the air, such as chlorine, chlorine dioxide, hydrogen peroxide, peracetic acid and aldehyde compounds, etc. In addition, since the composition of the present invention can be changed into a moist or solution state, which increases the contact surface between the active ingredients and irritating gases, the composition of the present invention can absorb and neutralize it more effectively than vitamin C itself. Irritating gas.
  • the aqueous composition solution of the present invention can also effectively absorb and neutralize irritating gases, especially irritating gases in oxidative disinfectants. Compared with the aqueous solution of vitamin C, the aqueous solution of the composition of the present invention can significantly improve the absorption capacity of irritating gases.
  • the base material containing the composition of the present invention can also effectively absorb and neutralize the irritating odor gas generated by the volatilization of high-efficiency disinfectants in the air, and is suitable for disinfection workers such as hospital infection control and epidemic prevention.
  • the base material containing the composition of the present invention can also effectively absorb and neutralize the irritating odor gas generated by the volatilization of high-efficiency disinfectants in the air, and is suitable for disinfection workers such as hospital infection control and epidemic prevention.
  • it provides protective effects on the respiratory tract, skin, and mucous membranes; it can also be used as an antagonist for those who accidentally ingest or misuse high-efficiency disinfectants, leading to disinfectant poisoning.
  • the base material containing the composition of the present invention can also be used in many technical fields such as daily cleaning disinfection products and air freshening equipment (such as reducing the concentration of formaldehyde and glutaraldehyde in the environment), and may be used for microbial protection in certain specific fields. or play a role in air purification.
  • the multilayer material containing the composition of the present invention can adsorb and neutralize a variety of irritating gases, so it can be applied to different occasions and effectively adsorb and neutralize chlorine, hydrogen peroxide, peracetic acid, and aldehydes. Compounds and other gases.
  • masks containing the composition of the present invention may reduce the use of activated carbon masks in some specific fields, and the components in the composition are mostly edible or harmless substances to the human body.
  • masks containing the composition of the present invention may reduce the risk of activated carbon powder in traditional activated carbon masks being inhaled by the human body or polluting the working environment. This is because activated carbon requires high energy consumption in the production process, and old activated carbon that has adsorbed toxic and hazardous substances is considered hazardous solid waste by current regulations in some countries.
  • the active ingredients in the base material, multi-layer material or mask containing the composition of the present invention can be extracted by solvent to obtain an extract of the above-mentioned materials. Therefore, in an emergency, it is also possible to quickly extract the active ingredients from the material of the present invention.
  • the extract of the active ingredient biosorbent can be used for on-site detoxification of those who accidentally ingested or misused the disinfectant through oral administration, skin and mucous membrane rinses, wet compresses, etc.
  • the multi-layer material containing the composition of the present invention can achieve a hygroscopic agent-water concentration gradient balance between the center and edge positions of the multi-layer material, which is conducive to the volatilization of moisture and taking it away. heat, thereby lowering the temperature around the multilayer material.
  • the wearer's facial temperature will be lower and the wearer will not feel stuffy.
  • the facial skin temperature is lower than the skin temperature under the nostrils.
  • composition of the present invention has the property of color development and indication, and the composition will change color after high-intensity use in the air. Therefore, when the composition of the present invention is used in products such as masks and multi-layer materials, it can provide timely feedback on the status of active ingredients and facilitate replacement of the composition.
  • the composition of the present invention has excellent stability.
  • the composition of the present invention contains bioactive ingredients such as enol-containing compounds, sulfhydryl-containing compounds, and amino acids. Even if it is left standing in the air for a long time, the composition can still absorb and neutralize irritating gases in the air. , such as chlorine, chlorine dioxide, hydrogen peroxide, peracetic acid and aldehyde compounds, etc.
  • adding plant extracts to the composition of the present invention can have a light-shielding effect and greatly increase the shelf life of the active ingredients, allowing them to absorb and neutralize irritating gases in the air after long-term storage.
  • the composition of the present invention has better stability.
  • compositions of the present invention do not affect the performance of disinfecting alcohols.
  • the composition also contains protein coagulant and plant extract components.
  • the corresponding composition may have the effect of inhibiting the activity of surface proteins of microorganisms such as viruses, bacteria, fungi, etc., and may enhance and prolong the activity of surface proteins of microorganisms such as viruses, bacteria, and fungi when used in conjunction with disinfectant alcohol.
  • the disinfection effect of alcohol also reduces the irritation of disinfectant alcohol to the skin.
  • Trichloroisocyanuric acid disinfectant tablets Hangzhou Langso Medical Disinfectant Co., Ltd. Available chlorine content is 500 ⁇ 50mg/tablet.
  • Sodium hypochlorite disinfectant Hangzhou Langso Medical Disinfectant Co., Ltd. Concentration 4.5-5.5% by weight.
  • Chlorine dioxide disinfectant tablets Beijing Hualong Xingyu Technology Development Co., Ltd. Chlorine dioxide content is 100 ⁇ 10mg/tablet.
  • Hydrogen peroxide lotion Shandong Ruitaiqi Washing and Disinfection Technology Co., Ltd. Concentration 2.5-3.5% by weight.
  • Peracetic acid disinfectant (binary packaging): Shandong Anjie Hi-Tech Disinfection Technology Co., Ltd. Concentration 15-18% by weight.
  • Glutaraldehyde disinfectant Shanghai Likang Disinfection High-Tech Co., Ltd. Concentration 2.1-2.6% by weight.
  • Chlorine test paper Hangzhou Langso Medical Disinfectant Co., Ltd. The concentration is 0-2000ppm.
  • Hydrogen peroxide test paper Hangzhou Luheng Biotechnology Co., Ltd. The concentration is 0-25ppm.
  • Peracetic acid test paper Hangzhou Luheng Biotechnology Co., Ltd. The concentration is 0-40ppm.
  • Glutaraldehyde test paper Hangzhou Luheng Biotechnology Co., Ltd. The concentration is 0-3% by weight.
  • Chlorine dioxide test paper Changsha Shangqing Environmental Protection Technology Co., Ltd. The concentration is 0-20ppm.
  • Formaldehyde solution Sinopharm Chemical Reagent Co., Ltd. Analytically pure (contains methanol inhibitor). Content 37-40% by weight.
  • NaHCO 3 sodium bicarbonate: Tianjin Zhiyuan Chemical Reagent Co., Ltd. Analytically pure.
  • Vitamin C (ascorbic acid): purchased from Fuchen (Tianjin) Chemical Reagent Co., Ltd. Analytically pure.
  • Acetylcysteine injection (4g: 20ml): for content analysis, Hangzhou Minsheng Pharmaceutical Co., Ltd., national drug approval number H20051788.
  • N-acetylcysteine for preparation, Henan Jimei Chemical Products Co., Ltd., food additive.
  • EDTA Na 2 (disodium ethylenediaminetetraacetate): Shanghai Chemical Reagent Co., Ltd. Analytically pure.
  • Glycerin Hunan Erkang Pharmaceutical Co., Ltd. medical supplements.
  • Propylene glycol (1,2 propylene glycol): Hunan Erkang Pharmaceutical Co., Ltd. medical supplements.
  • Sodium hydrogen phosphate-disodium hydrogen phosphate buffer Nanjing Chemical Reagent Co., Ltd. Analytically pure, self-prepared.
  • Ethylparaben Hunan Erkang Pharmaceutical Co., Ltd. medical supplements.
  • Activated carbon layer fabric (carbon sandwiched non-woven fabric): Kunshan Green Chuang Electronic Technology Co., Ltd.
  • Polyester filter cotton primary air filter cotton, thickness 0.3-1mm.
  • Catalase Henan Yangshao Biochemical Engineering Co., Ltd. food ingredients.
  • L-Alanine Henan Jiazhi Chemical Products Co., Ltd. Food grade additives.
  • L-serine Henan Jiazhi Chemical Products Co., Ltd. Food grade additives.
  • Polysorbate-80 Taicang Pharmaceutical Factory. medical supplements.
  • Triethanolamine Sinopharm Chemical Reagent Co., Ltd. Analytically pure.
  • Disinfection alcohol Prepare your own with absolute ethanol and water, or use commercially available finished products directly, with an ethanol content of 70-75% (V/V). Changshu Yangyuan Chemical Co., Ltd. Analytically pure.
  • Egg white The egg white part of commercially available raw eggs is rich in a variety of proteins, with the main component being ovalbumin.
  • Cotton masks The weight is about 9.8g/piece, double-layer pure cotton knitted fabric. It is a washable and reusable daily knitted mask mainly used for decoration, cleaning, and warmth.
  • the estimated cotton thread specification is 40S, and the density of each layer of fabric is about 200g/ m2 . , filter layer area is about 105.2cm 2 , neutral packaging, selling price is about 0.63RMB/piece.
  • Disposable non-woven masks robust Medical nursing masks. ROBUST MEDICAL LIMITED. The price is about 0.8RMB/piece.
  • Glucono-delta-lactone Anhui Xingzhou Pharmaceutical Food Co., Ltd., food additive.
  • Grape seed extract proanthocyanidins: Xi'an Rongzhen Biotechnology Co., Ltd., proanthocyanidin content 95% OPC (UV), [CAS No]: 84929-27-1.
  • Lemon oil Guangzhou Huixin Biotechnology Co., Ltd., [CAS No]: 8008-56-8, the main component is limonene.
  • 3M TM 8246 Occupational Protective Mask R95 activated carbon anti-particle mask, used for acid gas and oily/non-oily particle protection, Minnesota Mining and Manufacturing.
  • the retail price is about 28RMB/piece.
  • 3M TM 8247 Occupational Protective Mask R95 activated carbon anti-particle mask, used for organic vapor odor and oily/non-oily particle protection, Minnesota Mining and Manufacturing. Retail price is about 28RMB/piece.
  • composition A aqueous solution
  • Composition B aqueous solution
  • composition C aqueous solution
  • composition D aqueous solution
  • composition A aqueous solution
  • composition B aqueous solution
  • 6 mg of glycerin aqueous solution
  • 6 mg of glycerin aqueous solution
  • Ethyl hydroxyphenyl ester stir evenly. After the above solution is evenly infiltrated into the base material of the mask, it is dried in a nitrogen atmosphere to obtain mask A.
  • 102 represents the ear strap of the mask
  • 101 represents the base material of the mask, which has the above composition adsorbed thereon.
  • composition A aqueous solution
  • composition B aqueous solution
  • glycerin aqueous solution
  • 6 mg of ethyl hydroxyphenyl ester 6 mg
  • the above solution is uniformly infiltrated into the base material of the mask, it is dried in a nitrogen atmosphere to obtain the base material 101 of mask B.
  • the activated carbon layer 201 is fixed on the outside of the base material 101 by hot melting to obtain the mask B.
  • 102 represents the ear strap of the mask
  • 101 represents the base material of the mask
  • 201 represents the activated carbon layer of the mask.
  • a melt-blown cloth filter layer can also be inserted between the activated carbon layer 201 and the base material 101 to block fine particles. Since peracetic acid is an organic vapor, adding an activated carbon layer to mask B can effectively strengthen the physical adsorption of the mask, thereby achieving a combined filtration effect of physical adsorption and chemical adsorption neutralization.
  • the above solution is evenly infiltrated into the base material of the mask, it is dried in a nitrogen atmosphere to obtain the second base material 301 of the mask C.
  • Polyester filter cotton with a thickness of 3 mm is used as the middle isolation layer 302. Arrange the first base material 101, the middle isolation layer 201 and the second base material 301 in order from the outside to the inside, and prepare a multi-layer mask C by hot melting.
  • 102 represents the ear strap of the mask
  • 101 represents the first base material of the mask
  • 302 represents the second base material
  • 301 represents the second base material. Since the active substances in the first base material 101 and the second base material 302 need to work in different pH environments, the active substances in the first base material 101 are relatively stable in a weakly acidic environment of pH 5.0-6.2, while peroxidation Hydrogenase can maximize the catalytic decomposition of hydrogen peroxide in a pH 7.0 environment. Therefore, the middle isolation layer 302 can effectively isolate the active substances of the two base materials, and the use of polyester filter cotton will not affect the air circulation. . In addition, arranging the second base material 301 on the inside close to the person's face can make the second base material 301 have a relatively high temperature, which is more conducive to the decomposition of hydrogen peroxide by catalase.
  • the measured pH of 5000ppm peracetic acid disinfectant is 2.1, which is highly acidic and exceeds the color development conditions of peroxide test paper. It needs to be neutralized by acid and alkali before using test paper to detect the peroxide concentration.
  • the neutralization product of peracetic acid and acetylcysteine can cause the peroxide detection test paper to fade, and the maximum value of the color change at the moment when the test paper is put into the solution is taken as the reading.
  • Peroxide disinfectants are more oxidizing than chlorine-containing disinfectants and can cause the chlorine test paper to turn brown and then further oxidize, causing the brown product to fade. Therefore, the chlorine test paper cannot be directly put into the reaction system.
  • the reaction between glycine and glutaraldehyde can be carried out at room temperature.
  • the reaction condition is pH>5.0.
  • a yellow product is usually generated within 5-10 seconds and gradually becomes darker.
  • the detection range of currently commercialized glutaraldehyde test paper is 0 -3%, most are also glycine colorimetric methods. Since the color reaction of the test paper is also yellow-orange, the test paper reading is easily disturbed.
  • reaction rate constant K 2 is 1.0 ⁇ 10 5 M -1 s -1 , which is much lower than the cysteine side chain K 2 of 3.0 ⁇ 10
  • the reaction rate constant is 7 M -1 s -1 , so this slow neutralization effect cannot be observed in titration experiments.
  • aqueous solutions of vitamin C and N-acetylcysteine can effectively neutralize hypochlorous acid in chlorine-containing disinfectants, while aqueous solutions of glycine can effectively neutralize glutaraldehyde-containing disinfectants. agent.
  • the moisture absorbing agent has the function of absorbing water and can change the composition into a moist state or a solution state, that is, corresponding to the vitamin C aqueous solution, N-acetylcysteine aqueous solution and Glycine aqueous solution, while the moisture attractant will not participate in the reaction between the above compounds and chlorine, and will not affect the efficiency of the neutralization reaction.
  • the above results confirm that the compounds of the present invention can effectively adsorb and neutralize chlorine-containing disinfectants, peroxide-containing disinfectants and glutaraldehyde-containing disinfectants, and can adsorb and neutralize the irritating gases volatilized by the above-mentioned disinfectants. .
  • (II) Prepare the disinfectant according to the medical disinfection concentration in Table 1, transfer 5 mL of disinfectant into a 100 mL iodine bottle through a pipette, and slightly add iodine to the bottle to evaporate the disinfectant.
  • the mask A of the invention is placed in the central area of the above-mentioned iodine bottle.
  • the front and back sides of the central area of the mask are respectively pasted with test paper with a length of about 10mm.
  • the two test papers are 3-5mm apart to facilitate the passage of airflow.
  • the test paper used is chlorine test paper; for chlorine dioxide disinfectant, the test paper used is chlorine test paper Chlorine oxide test paper; for glutaraldehyde disinfectant, the test paper used is glutaraldehyde test paper.
  • the mask of the present invention can effectively absorb and neutralize irritating gases in various disinfectants.
  • mask A is adsorbed with the composition of the present invention, which contains bioactive ingredients such as vitamin C, N-acetylcysteine, glycine, etc. Therefore, the above qualitative experiment can also confirm that it is effective against irritating gases (such as those in disinfectant solutions). irritating gases), the composition of the present invention has excellent absorption capacity. In addition, the composition of the present invention can absorb and neutralize irritating gases more effectively than vitamin C itself.
  • bioactive ingredients such as vitamin C, N-acetylcysteine, glycine, etc. Therefore, the above qualitative experiment can also confirm that it is effective against irritating gases (such as those in disinfectant solutions). irritating gases), the composition of the present invention has excellent absorption capacity. In addition, the composition of the present invention can absorb and neutralize irritating gases more effectively than vitamin C itself.
  • the mask A of the present invention into a 250 ml conical flask, and add 100 mL of water to the conical flask. Stir the water in the above-mentioned Erlenmeyer flask to fully dissolve the components of mask A in the water to obtain the mask extract. Take out 10mL of mask extract and perform a titration experiment according to the method in Table 1 to determine the content of active substances in the mask. The measurement results are magnified 10 times to obtain the content of active substances in the mask. The test results are shown in Table 2.
  • the above results can confirm that the mask of the present invention can effectively absorb and neutralize irritating gases in various disinfectants.
  • mask A adsorbs the composition of the present invention, so the above results can also confirm that the composition of the present invention has excellent absorption capacity for irritating gases (such as irritating gases in disinfectant solutions).
  • the composition of the present invention can absorb and neutralize irritating gases more effectively than vitamin C itself.
  • the mask turns yellow within a few hours after being exposed to the air. After the tester wears the above mask A, the tester can smell a slightly faint disinfectant smell, but the smell is not irritating.
  • test paper on the outside of the mask changes color, but the test paper on the inside of the mask does not change color.
  • the mask of the present invention still has the ability to absorb disinfectants and neutralize irritating gases, and the mask of the present invention has excellent stability.
  • mask A is adsorbed with the composition of the present invention, which contains bioactive ingredients such as vitamin C, N-acetylcysteine, glycine, etc., each of which has different reducing properties or reactivity. Even if it is left standing in the air for a long time, For a long time (such as 14 days), the composition can still absorb and neutralize irritating gases (such as irritating gases in the air or in disinfectants). Therefore, the above results can also confirm that the composition of the present invention has excellent stability. sex. In particular, the combination of the invention has significantly improved stability compared to vitamin C itself.
  • the above results can confirm that even if it is oxidized and discolored by air, the mask of the present invention still has the ability to absorb disinfectants and neutralize irritating gases, and the mask of the present invention has excellent stability.
  • mask A adsorbed the composition of the present invention, so the above results can also confirm that the composition of the present invention has excellent stability.
  • the combination of the invention has significantly improved stability compared to vitamin C itself.
  • the microbial limits of non-sterile masks are: bacteria ⁇ 100CFU/g, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, hemolysis Sexual streptococci and fungi shall not be detected.
  • mask A is unpacked in a class 100 ultra-clean bench, extracted with 0.9% sodium chloride injection, and the extract is added to agar culture medium.
  • mask A was placed in an environment with a relative humidity of 70-95% and a temperature of 25-35°C for two weeks, then soaked in water to dilute the preservative, and then sampled and operated in an open environment to observe The impact of environmental bacteria on masks.
  • the test results are shown in Table 4.
  • the microbial index of the mask not only meets the requirements of industry standards, but also inhibits environmental microorganisms.
  • the cultured environmental colony microorganisms are mainly Paenibacillus urinae, which can produce spores and is resistant to harsh environments (such as preservatives), so it grows in low-concentration preservative environments.
  • this bacterium is a non-pathogenic background microorganism, mostly coming from animal urine.
  • reaction end point of glycine (or other amino acids) neutralizing glutaraldehyde disinfectant is determined by the following method:
  • step (4) Use sodium hydroxide aqueous solution to titrate the mixed solution in step (4) until the pH is 8.2;
  • step (7) Cool the mixed liquid in step (6) and measure the pH value of the mixed liquid;
  • step (9) Dilute the mixed solution of step (8), and titrate the mixed solution of step (8) using sodium hydroxide aqueous solution to a pH of 8.2;
  • step (10) Use sodium hydroxide aqueous solution to titrate the mixed solution in step (10) to pH 9.2, and record the volume V 2 (mL) of the titrant;
  • V 1 represents the volume of sodium hydroxide standard titration solution consumed after formaldehyde is added to the sample diluent for measurement, in milliliters (mL);
  • V 2 represents the volume of sodium hydroxide standard titration solution consumed after adding formaldehyde in the reagent blank test, in milliliters (mL);
  • C NaOH represents the concentration of sodium hydroxide standard titration solution, in moles per liter (mol/L);
  • MW amino acid represents the molar mass (molecular weight) of the amino acid, in grams per mole (g/mol);
  • the amino acid used in the embodiment of the present invention is glycine, and its molar molecular weight is 75.07g/mol.
  • Table 5 shows the end-point test results of the reaction between glutaraldehyde disinfectant and glycine.
  • the analysis method of the present invention can accurately obtain the stoichiometric point of the material consumption ratio of the neutralization reaction between glutaraldehyde and amino acid substances, that is, accurately obtain the end point of the neutralization reaction and obtain the amount of consumed amino acids.
  • the protective limit performance and color rendering performance of the mask of the present invention were tested by the following methods.
  • the color rendering performance of the mask is similar to the mask protective limit performance experiment. The difference is:
  • 3M TM occupational exposure protective mask was used as a comparative example.
  • Paste a piece of glutaraldehyde test paper on the inner surface of mask D, and wrap the test paper with waterproof and breathable material (such as the blue waterproof layer of a medical mask) to prevent it from being contaminated by the active ingredients of mask D.
  • Set the water bath to about 95°C and place a 100ml evaporating dish on the water bath to fully preheat.
  • Use a pipette to measure 25 ml of 2 wt% glutaraldehyde disinfectant solution and add it to the preheated evaporating dish.
  • the comparative example uses 3M TM 8247 organic vapor and particle protective mask, which conducts the above experiments under the same conditions.
  • the mask was placed in a drying dish and vacuum dried for more than 24 hours before the test.
  • the experimental method for the protective performance of hypochlorous acid chlorine-containing disinfectant is similar to the protective performance test of glutaraldehyde disinfectant. The difference is that a chlorine-containing disinfectant with an effective chlorine concentration of 30,000 ppm is used, and the test paper used is a chlorine test paper. Set the water bath at about 45°C and heat and fumigate for 4 hours. For the comparison example, 3M TM 8246 acid gas and particle protective mask was used.
  • the experimental method for the protective performance of peracetic acid disinfectant is similar to the test for the protective performance of chlorine-containing disinfectant. The difference is that 15000 ppm peracetic acid disinfectant is used, and the test paper is peracetic acid test paper. Set the water bath at about 45°C, heat and fumigate for 6 hours, then close the water bath and use the residual heat to leave it for 17.5 hours. For the comparison example, 3M TM 8246 acid gas and particle protective mask was used.
  • the experimental method for the protective performance of hydrogen peroxide disinfectant is similar to the protective performance test of chlorine-containing disinfectant. The difference is that 30,000 ppm hydrogen peroxide disinfectant is used, and the test paper is a hydrogen peroxide test paper. Set the water bath at about 45°C, heat and fumigate for 6 hours and then close the water bath. For the comparison example, 3M TM 8246 acid gas and particle protective mask was used.
  • test method for the protective performance of chlorine dioxide disinfectant
  • the test method is similar to the protective performance test of chlorine-containing disinfectant. The difference is that 20,000 ppm chlorine dioxide disinfectant is used, and the test paper is hydrogen peroxide test paper. Set the water bath at about 45°C, heat and fumigate for 6 hours, then close the water bath and use the residual heat to leave it for 18 hours.
  • 3M TM 8246 acid gas and particle protective mask was used.
  • the liquid used for fumigation in the evaporating dish can also be added by gradual titration until the test paper changes color, so as to simulate the situation of mask D after repeated use. Compared with the comparative example Compare.
  • 3M TM masks are used as a comparative example.
  • the specific masks used include 3M TM 8246 type masks and 3M TM 8247 type masks.
  • the above examples can confirm that the mask D of the present invention is significantly better than the comparative example in protecting the volatile gases of trichloroisocyanuric acid, chlorine dioxide, and glutaraldehyde disinfectant.
  • the mask D of the present invention is equivalent to the comparative example.
  • the protection against hydrogen peroxide the mask D of the present invention has a relatively long-lasting effect.
  • the test paper on the mask D did not change color until 6 hours after the experiment was carried out.
  • the above results show that in the environment of the above-mentioned high concentration of irritating gas, the mask of the present invention has strong protective ability.
  • the inventor unexpectedly discovered that due to the use of amino acids in the formula of the mask composition, the mask of the present invention will produce a specific discoloration reaction under the irritating gas environment of high concentrations of disinfectants, that is, under the irritating gas environment of different disinfectants, After repeated use in the environment, the floor mask of the present invention will produce different discoloration reactions.
  • the mask of the present invention will turn red after repeated use.
  • the mask of the present invention will turn dark yellow after repeated use.
  • glutaraldehyde disinfectant the mask of the present invention will turn dark brown after repeated use.
  • the active ingredients in the mask will oxidize and the mask will turn yellow.
  • the degree of color change mentioned above is related to the concentration of volatile gases in the disinfectant and the use time of the mask. Among them, the degree of color change can also reflect the time that the mask of the present invention can continue to be used. For example, the deeper the color change of the mask, the shorter the time the mask of the present invention can continue to be used.
  • the mask of the present invention can not only efficiently absorb and neutralize irritating gases in various disinfectants, but can also perform a discoloration reaction according to the state of the active ingredients in the mask, and timely reflect how long the mask can continue to be used.
  • the mask of the present invention can not only effectively absorb and neutralize irritating gases in disinfectants, but also has additional heat dissipation properties. Among them, the heat dissipation performance is specifically achieved through the following methods.
  • the tester wears a mask and takes a thermal image temperature measurement
  • the tester takes off the mask and takes a thermal image temperature measurement.
  • the heat is blocked by the mask and transferred to the facial skin, so the facial skin in contact with the mask has higher humidity and temperature.
  • the above steps reflect the impact of different masks on the tester's facial temperature by measuring the temperature of the tester's face when wearing and taking off the mask.
  • the mask A of the present invention is used as an example, and the disposable medical non-woven nursing mask and cotton mask are used as a comparative example to detect the above temperatures respectively.
  • Figure 5-a shows the thermal image when wearing a disposable medical non-woven nursing mask
  • Figure 5-b shows the thermal image of the facial skin taken at the moment when the above mask is taken off
  • Figure 6-a shows the thermal image when wearing a cotton mask.
  • Thermal image Figure 6-b shows the thermal image of facial skin taken at the moment when the above mask is taken off
  • Figure 7-a shows the thermal image when wearing the mask A of the present invention
  • Figure 7-b shows the thermal image taken at the moment when the above mask is taken off Thermal image of facial skin.
  • the skin surface temperature of the part of mask A that is in contact with the skin is significantly lower than that of the non-contact part.
  • the mask of the present invention not only has the above-mentioned ability to absorb and neutralize irritating gases, but also has obvious heat dissipation performance.
  • the maximum temperature of the tester's facial skin is 36.6°C.
  • the above-mentioned temperature is close to the body temperature of the human body, so the wearer will not feel stuffy when wearing the mask of the present invention.
  • the temperature of the facial skin will not increase. Therefore, the mask of the present invention has excellent heat dissipation performance.
  • the composition of the present invention can be stored in a vacuum spray bottle with a piston structure at the bottom, or in a traditional spray bottle with a straw as shown in Figure 8.
  • 1001 is a transparent plastic bottle with a wall thickness of 0.4-5mm
  • 1002 is a cock spray button
  • 1003 is a rotatable nozzle
  • 1004 is a suction tube
  • 1005 is a liquid sealing agent, with To isolate the composition solution and air
  • 1006 is the composition solution of the present invention.
  • Such a packaging structure can reduce the contact area between the composition and air.
  • the capacity of the spray bottle is 20 ml
  • the wall thickness is 1.2 mm
  • the liquid sealant uses 0.6 ml of liquid paraffin
  • the liquid sealant thickness is 1.5 mm.
  • approximately 0.094ml of liquid can be sprayed out each time the key is pressed.
  • a vacuum spray bottle with a piston AS at the bottom can also be used to store the composition solution of the present invention.
  • the composition solution is a 2.7% (W/V) vitamin C solution and a composition solution of mask E (see Example 2).
  • the storage environment is an indoor room with a north-facing window, no direct sunlight, but with natural light and fluorescent indoor lighting.
  • the half-life of an active ingredient such as a vitamin).
  • k represents the rate constant (d -1 )
  • C 0 represents the initial concentration
  • C represents the concentration at t
  • t-time is days (d)
  • t 1/2 represents the half-life.
  • the formulas of vitamin C solution or mask E were stored in different ways.
  • plastic bottles can be used to store vitamin C solution.
  • a plastic bottle can be used to store the vitamin C solution, and a liquid sealing agent can be added to the plastic bottle for further sealing.
  • an AS vacuum spray bottle can be used to store the formula of mask E; wherein the formula of mask E contains grape seed extract (proanthocyanidins).
  • test results of the above examples can confirm that using the container shown in Figure 8 to store the composition solution of the present invention, the composition of the present invention can be stored for a long time without deterioration, with a half-life of 443-3253 days, up to 3253 days. .
  • the inventor unexpectedly discovered that because the grape seed extract in the formula of Mask E has a maximum absorbance at 546nm, it can absorb blue-violet light, thus exhibiting the effect of a brown sunscreen.
  • This composition formula also greatly extends the shelf life of light-sensitive vitamin C, with a half-life of up to 3253 days. This makes the composition of the present invention have significant industrial applicability and commercial value.
  • the composition of the present invention obviously has significantly better stability.
  • Preserving the composition of the present invention in the above manner not only extends the storage time of the composition of the present invention, but also allows the composition of the present invention to be accessed at any time. It also provides a method for quickly preparing the mask of the present invention, which includes:
  • step (2) Spray the composition liquid of step (1) onto the inside and/or outside of the mask by spraying.
  • the mask used in step (2) can be a commercially available disposable mask or a cotton mask, etc.
  • the spray bottle body 1001 is tilted, and the rotatable nozzle 1003 is adjusted to a distance of about 5-10cm from the mask D, and the front and back sides of the cotton mask are Spray the composition liquid evenly, press the spray button 17 times each, a total of 34 times, approximately 3.2 ml of the composition liquid can be sprayed, thereby quickly completing the preparation of the occupational exposure protective mask D.
  • the spray bottle containing the composition solution of the present invention can be stored separately from the ordinary mask.
  • the composition of the present invention can be immediately sprayed on the inside and/or outside of the ordinary mask to obtain the mask of the present invention.
  • the mask can be stored in a dry environment and sprayed with the solution only when used. Since the middle layer of existing masks is mostly made of polypropylene melt-blown cloth and electret electrostatic process, such masks must be stored in an extremely dry environment to avoid loss of static charge.
  • the above method can not only quickly obtain the mask of the present invention, but also store the composition and the mask separately under different conditions to further extend the storage time of the composition and the mask.
  • Example 13 Disinfection effect of the composition of the present invention and its compatibility with alcohol-based disinfectants
  • the present invention designs relevant tests to detect the performance of the composition and alcohol-based disinfectants. compatibility. Among them, the disinfection effect of the composition and its compatibility with alcohol-based disinfectants were tested by the following methods.
  • step (3) Shake the container in step (3) for 5 minutes, and then observe the protein denaturation and precipitation effect.
  • compositions 1 and 2 were controlled to be about 5.5-6.2.
  • composition 1 has good protein protection effect.
  • Composition 1 is mixed with disinfectant alcohol (Experiment B)
  • the effect of protein denaturation and precipitation can still be achieved, so Composition 1 will not reduce the effect of disinfectant alcohol.
  • composition 2 water-propylene glycol solvent, containing protein coagulant and plant extract
  • egg white egg white
  • composition 2 can be used to slowly inhibit the biological activity of microbial surface proteins.
  • disinfectant alcohol experiment D
  • protein coagulant and plant extract are added to the composition, the protein denaturation and precipitation effect can still be achieved.
  • composition 2 when Composition 2 is used in combination with disinfectant alcohol, the addition of protein coagulants and plant extracts will not only not affect the effect of disinfectant alcohol, but can also work synergistically with disinfectant alcohol to quickly inhibit protein activity while also sustaining the effect. Inhibit protein activity, thereby achieving stronger disinfection effect and achieving long-term disinfection.
  • the composition of the present invention propylene glycol can be used as a moisture absorbing agent, and the moisture absorbing agent can make the composition form a solution state after absorbing moisture in the air.
  • the water-propylene glycol system in this embodiment corresponds to the aqueous composition solution system of the present invention. Therefore, by adding protein coagulants and plant extracts, the composition of the present invention will not only not affect the disinfection effect of disinfectant alcohol, but can also perform collaborative disinfection, quickly inhibit protein activity and achieve long-term disinfection, achieving stronger and lasting disinfection. Effect.
  • moisture-absorbing agents such as propylene glycol
  • plant extracts such as grape seed extract
  • Adding the above-mentioned plant extracts and moisture attractants can reduce the use of alcohol-based disinfectants, thereby reducing their irritation to the skin.

Abstract

La présente invention concerne une composition, comprenant, sur la base du poids total de la composition : (A) environ 0,1 à 99 % en poids d'un bio-adsorbant, et (B) environ 0,0001 à 99 % en poids d'un agent hygroscopique. La présente invention concerne également un substrat, qui comprend la composition. La présente invention concerne en outre un matériau multicouche A et un matériau multicouche B, qui comprennent le substrat. La présente invention concerne également un masque, qui comprend le substrat ou les matériaux multicouches.
PCT/CN2022/092725 2022-05-13 2022-05-13 Composition et son utilisation, et matériaux la comprenant WO2023216238A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2022/092725 WO2023216238A1 (fr) 2022-05-13 2022-05-13 Composition et son utilisation, et matériaux la comprenant

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2022/092725 WO2023216238A1 (fr) 2022-05-13 2022-05-13 Composition et son utilisation, et matériaux la comprenant

Publications (1)

Publication Number Publication Date
WO2023216238A1 true WO2023216238A1 (fr) 2023-11-16

Family

ID=88729512

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2022/092725 WO2023216238A1 (fr) 2022-05-13 2022-05-13 Composition et son utilisation, et matériaux la comprenant

Country Status (1)

Country Link
WO (1) WO2023216238A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012826A1 (fr) * 1990-02-27 1991-09-05 Allergan, Inc. Compositions detruisant le peroxyde d'hydrogene et procedes d'utilisation de cette composition
US5312588A (en) * 1990-02-27 1994-05-17 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of making and using same
US6022732A (en) * 1997-04-09 2000-02-08 Allergan Hydrogen peroxide destroying compositions and methods of using same
US20110305736A1 (en) * 2010-06-10 2011-12-15 Dr. Suwelack Skin & Health Care Ag Stratiform Perforated Biomatrices
CN107126643A (zh) * 2017-06-16 2017-09-05 王宇 一种复合材料层及含有该复合材料层的鼻孔即时贴
CN112493575A (zh) * 2020-09-18 2021-03-16 安徽云飞芳植生物科技有限公司 新型口罩制作方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012826A1 (fr) * 1990-02-27 1991-09-05 Allergan, Inc. Compositions detruisant le peroxyde d'hydrogene et procedes d'utilisation de cette composition
US5312588A (en) * 1990-02-27 1994-05-17 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of making and using same
US6022732A (en) * 1997-04-09 2000-02-08 Allergan Hydrogen peroxide destroying compositions and methods of using same
US20110305736A1 (en) * 2010-06-10 2011-12-15 Dr. Suwelack Skin & Health Care Ag Stratiform Perforated Biomatrices
CN107126643A (zh) * 2017-06-16 2017-09-05 王宇 一种复合材料层及含有该复合材料层的鼻孔即时贴
CN112493575A (zh) * 2020-09-18 2021-03-16 安徽云飞芳植生物科技有限公司 新型口罩制作方法

Similar Documents

Publication Publication Date Title
US7858124B2 (en) Anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use
US7976876B2 (en) Anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use
JP2012072134A (ja) 抗菌用銀イオン生成液、その液から生成された銀イオン抗菌液及びその抗菌液を生成する生成方法
US20210178106A1 (en) Nitric oxide generating systems for inhalation
CN108743702A (zh) 一种抗霾毒喷剂及其制备方法
Gottardi Iodine as disinfectant
CN109846113A (zh) 一种可自提供一氧化氮的口鼻卫生用品
WO2023216238A1 (fr) Composition et son utilisation, et matériaux la comprenant
JP2024052763A (ja) 一酸化窒素発生システム
JP2005218613A (ja) マスク
CN105381454B (zh) 一种含海藻糖的鼻腔润湿剂
RU2644316C1 (ru) Профилактическая лицевая маска для противомикробной защиты при заболеваниях верхних дыхательных путей, передающихся воздушно-капельным путем
CN116471936A (zh) 产生稳定地包含游离的有效氯物质和过氧化物的组合物的方法和用途
JPH02116302A (ja) 防臭殺菌性靴中敷
CN102283450A (zh) 银离子灭菌消毒口罩及其制造方法
Lachenmeier Antiseptic drugs and disinfectants with experience of the second year of COVID-19 pandemic-related side effects
CN110272023A (zh) 一种全天候室内除醛装置及其使用方法
Chooi et al. COVID 19: The safety profile of common disinfectants used for sanitization
EP1576880A1 (fr) Composition antibactérienne, antivirale et antifongique, sa préparation et utilisation
JPH0639367B2 (ja) 脱臭及び殺菌用組成物
Shambhavi et al. BT100, a three-in-one, multipurpose disinfecting, deodorizing, and air-cleaning solution with an effective, gradual, and continuous gaseous chlorine dioxide-releasing substance
US20230110299A1 (en) Hygiene Base Composition, and Production Method and Application Method Thereof
CN106472560A (zh) 一种氧气湿化液抑菌剂
TW202333755A (zh) 用於預防及治療細菌及病毒感染之呼吸道病症的水溶液醫藥組合物及其行動防護給藥裝置
CN110583690A (zh) 一种室内空气净化凝胶及其使用方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 22941192

Country of ref document: EP

Kind code of ref document: A1