WO2023216238A1

WO2023216238A1 - Composition and use thereof, and materials comprising same

Info

Publication number: WO2023216238A1
Application number: PCT/CN2022/092725
Authority: WO
Inventors: 李平; 黄亦成; 卜书红; 杨玲; 孙朝荣; 胡燕锋; 杜毅; 张健
Original assignee: 李平
Priority date: 2022-05-13
Filing date: 2022-05-13
Publication date: 2023-11-16

Abstract

A composition, comprising, on the basis of the total weight of the composition: (A) about 0.1-99 wt% of a bio-adsorbent, and (B) about 0.0001-99 wt% of a hygroscopic agent. The present invention also relates to a substrate, which comprises the composition. The present invention further relates to a multilayer material A and a multilayer material B, which comprise the substrate. The present invention also relates to a mask, which comprises the substrate or the multilayer materials.

Description

Compositions, their uses and materials containing them

Technical field

The present invention relates to the field of material technology, and in particular to a composition that adsorbs and neutralizes volatile gases of disinfectants, its use, and materials containing the same.

Background technique

A large number of highly effective disinfectants will be used in the prevention and control of the novel coronavirus pneumonia (COVID-19). High-efficiency disinfectants refer to disinfectants that can kill various microorganisms (including bacterial spores). Currently widely used disinfectants include chlorine-containing disinfectants (such as chloroisocyanuric acid disinfectant tablets, 84 disinfectant, bleaching powder, sodium hypochlorite, Chloric acid air disinfectant, liquid chlorine, and new chlorine dioxide, etc.), peroxide disinfectants (such as peracetic acid, hydrogen peroxide), aldehyde disinfectants, ethylene oxide, etc. Among them, chlorine-containing disinfectants and peroxide disinfectants are oxidizing disinfectants, also known as high redox potential disinfectants, which have broad-spectrum and efficient killing of microorganisms. However, this type of high-efficiency disinfectant is much more oxidative, corrosive, irritating, and allergenic to mucous membrane tissues such as skin, respiratory tract, and eyes than conventional medical skin and mucous membrane disinfectants such as iodine, benzalkonium bromide, and chlorhexidine. There have been reports of adverse reactions and physical damage to epidemic prevention personnel after being exposed to chlorine-containing disinfectants, reports of occupational asthma caused by peracetic acid, and reports of people accidentally taking peracetic acid disinfectant and chlorine dioxide disinfectant tablets. Reports of poisonings. Therefore, the occupational exposure injuries of high-efficiency disinfectants and the rescue of accidental poisoning are issues involving the safety of global anti-epidemic chemicals.

Under the current technical conditions, conventional disposable medical surgical masks, N95, and three-fold envelope-type activated carbon masks cannot effectively filter out low-concentration volatile chlorine in chlorine-containing disinfectants. Currently, the only personal respiratory protective equipment that can effectively filter out chlorine is professional protective equipment such as rubber gas masks and acid gas canisters (mainly composed of activated carbon, soda lime, and soda lime), as well as a few such as 3M ^TM 8246 that have acid gas protection capabilities. masks, but due to their high price, their popularity is not high.

CN 2109208U discloses an anti-virus and anti-bacteria activated carbon fiber with strong adsorption force, which enables it to have efficient adsorption capacity and anti-toxic effect on harmful gases such as benzene, sulfur dioxide, chlorine, ammonia and bacteria, as well as bacteria. However, in the field of water treatment, activated carbon usually needs to be in contact with tap water for more than 2 minutes to fully adsorb residual chlorine in tap water. In addition to simple physical adsorption, there is also a slow oxidation reduction of 2Cl ₂ + 2H ₂ O + C → 4HCl + CO ₂ reaction. In fact, the time it takes for volatile chlorine to pass through the mask is only a few milliseconds. The thin activated carbon fiber layer does not have time to capture inorganic small molecule gases such as chlorine. Only professional canisters or cartridges can filter them out. Therefore, activated carbon masks are mainly used to adsorb organic vapor and particulate matter with larger molecular volumes.

CN 111394728A discloses a further treatment method for chlorine gas in an acid etching copper recovery system. The chlorine gas and the etching liquid are mixed with gas and liquid, and then sent into the first-stage iron absorption tank to react with metallic iron to produce ferric chloride. This mainly involves using metallic iron as a reducing agent to absorb chlorine. However, this technology is not suitable for use on masks because reduced iron powder is likely to be inhaled into the lungs, causing diseases similar to pulmonary hemosiderosis.

CN 111330419A discloses a method for jointly absorbing chlorine gas using water and sodium hydroxide (liquid alkali). However, this technology is not suitable for use on masks. Alkaline substances may cause serious damage to facial skin and respiratory tract.

The "Technical Specifications for Disinfectants" discloses a technical solution for using sodium thiosulfate to neutralize chlorine-containing disinfectants and peroxide disinfectants. Sodium thiosulfate is a weakly alkaline and strongly reducing substance that is basically not absorbed when taken orally and can neutralize the acidity and oxidation of oxidizing disinfectants. However, the irritation of this substance to the respiratory mucosa is unknown, and there is no safety study on airway inhalation of this strongly reducing inorganic substance. On the other hand, sodium thiosulfate may produce elemental sulfur particles under the action of weak oxidants, such as Cl ₂ +Na ₂ S ₂ O ₃ +H ₂ O→2NaCl+S↓+H ₂ SO ₄ . This kind of new elemental sulfur particles are tiny and are inhalable particles. They may have adverse effects on lung tissue, so they are not suitable for use in masks involving respiratory protection. The "Expert Consensus on Health Emergency Rescue and Clinical Treatment at the Site of Sudden Mass Chlorine Gas Leak Accident (2017)" further pointed out that there is currently no specific antidote for chlorine gas poisoning.

Contents of the invention

In one aspect, the present invention relates to a composition characterized by comprising, based on the total weight of the composition,: (A) about 0.1-99% by weight of biosorbent and (B) about 0.0001-99% % by weight of moisture attractant.

In one embodiment, the biosorbent is selected from one or more of the following: (a) compounds containing enol structures; (b) compounds containing sulfhydryl groups; (c) amino acids; (d) biological enzymes.

In one embodiment, the moisture-absorbing agent is selected from the group consisting of diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, glycerol polyether, xylitol, sorbitol, propylene glycol glucoside, and sodium lactate. and combinations thereof.

In one embodiment, the composition further includes at least one of the following ingredients, based on the total weight of the composition: (e) about 0.00000001-1% by weight of a preservative; (f) about 0.00001-90% by weight of a preservative Acid-base buffer; (g) about 0.000001-5 wt% antioxidant; (h) about 0-1 wt% emulsifier; (i) about 0-20 wt% liquid sealant; (j) about 0 - 20% by weight of protein coagulant; (k) about 0-20% by weight of plant extract; (l) about 0.0001-2% by weight of odor masking agent.

In another aspect, the invention relates to an aqueous solution, characterized in that it contains the composition of the invention.

In one embodiment, the composition is present in an amount of about 30-80% by weight, based on the total weight of the aqueous solution.

In another aspect, the invention relates to a substrate, characterized in that the substrate contains the composition of the invention, and the substrate is selected from the group consisting of non-woven cloth, metal mesh, glass fiber, cotton cloth, and linen cloth. and filter cotton, preferably non-woven fabric.

In yet another aspect, the present invention relates to a multi-layer material A, characterized in that the multi-layer material includes the base material of the present invention as a base material; and an activated carbon layer as the first filter layer. In a preferred embodiment, a second filter layer is further included between the base material and the first filter layer.

In yet another aspect, the present invention relates to a multi-layer material B, characterized in that the multi-layer material includes the base material of the present invention as a first base material; an intermediate isolation layer including a porous breathable material that is not wetted by water. ; The second base material includes biological enzymes, moisture absorbing agents, preservatives and acid-base buffers.

In another aspect, the invention relates to a mask, characterized in that the mask contains the base material or multi-layer material of the invention.

In another aspect, the present invention relates to a method for preparing a mask of the present invention, which includes: (1) providing a composition solution of the present invention; (2) spraying the composition liquid of step (1) onto The inside and/or outside of the mask.

Description of the drawings

Figure 1 shows the structural diagram of the mask A of the present invention;

Figure 2 shows the structural diagram of the mask B of the present invention;

Figure 3 shows the structural diagram of the mask C of the present invention;

Figure 4 shows the structural diagram of the mask D of the present invention;

Figure 5 shows the thermal imaging thermometer when wearing a disposable medical non-woven nursing mask or removing the above mask;

Figure 6 shows the thermal image temperature measurement chart when wearing cotton or removing the above mask;

Figure 7 shows the thermal image thermometry when wearing the mask A of the present invention or taking off the above mask;

Figure 8 shows a spray bottle storing a solution of the composition of the present invention;

Figure 9 shows a schematic diagram of using a spray bottle to prepare the mask of the present invention.

In the figure: 101 represents the base material; 102 represents the ear hanging rope; 201 represents the activated carbon layer; 302 represents the middle isolation layer; 301 represents the second base material; 401 represents the base material; 1001 represents a transparent plastic bottle; 1002 Indicates the spray bottle button; 1003 indicates the nozzle; 1004 indicates the pipette; 1005 indicates the liquid sealant; 1006 indicates the composition solution.

Detailed ways

The present invention will be described in further detail below. Such description is for illustrative purposes and does not limit the invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention may also be implemented or applied through other different specific embodiments. Those skilled in the art can make various modifications and changes without departing from the spirit of the present invention.

General definitions and terminology

If not otherwise indicated, all publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In the event of a conflict, the definitions provided herein shall control.

Unless otherwise stated, all percentages, parts, ratios, etc. are by weight.

When an amount, concentration or other value or parameter is given as a range, preferred range or preferred upper and lower limit or as a specific value, it is to be understood that a specific disclosure is made from any upper range or preferred value to any lower limit. All ranges are formed by pairs of ranges or preferred values, regardless of whether the ranges are individually disclosed. Unless otherwise indicated, when a numerical range is cited herein, the stated range is intended to include the endpoints thereof and all integers and fractions within the range. The scope of the invention is not limited to the specific numerical values cited in defining the range. For example "1-8" encompasses 1, 2, 3, 4, 5, 6, 7, 8 and any sub-range consisting of any two of these values, such as 2-6, 3-5.

The terms "about" and "approximately" when used with numerical variables generally mean that the value of the variable and all values of the variable are within experimental error (for example, within a 95% confidence interval for the mean) or within ±10 of the specified value. %, or within a wider range.

The terms "includes," "includes," "has," "contains," or "involves" and their other variations herein are inclusive or open-ended and do not exclude other unrecited elements or method steps. . Those skilled in the art will understand that the above terms such as "comprising" encompass the meaning of "consisting of." The expression "consisting of" excludes any element, step or ingredient not specified. The expression "consisting essentially of" means that the scope is limited to the specified element, step or ingredient plus the optional presence of such elements, steps or ingredients that do not materially affect the basic and novel characteristics of the claimed subject matter. It will be understood that the expression "comprising" encompasses the expressions "consisting essentially of" and "consisting of".

The term "selected from" refers to one or more elements from the group listed thereafter, selected independently, and may include combinations of two or more elements.

When numerical values or range endpoints are described herein, it is to be understood that the disclosure includes the specific value or endpoint recited.

The term "one or more" or "at least one" as used herein means one, two, three, four, five, six, seven, eight, nine or more.

Unless stated otherwise, the terms "combinations thereof" and "mixtures thereof" mean multi-component mixtures of the respective elements, for example two, three, four and up to the maximum possible multi-component mixtures.

In addition, if the number of parts or components of the present invention is not specified before, it means that there is no limit to the number of occurrence (or existence) of the parts or components. Therefore, it should be read to include one or at least one, and the singular form of part or component also includes the plural unless the value clearly indicates the singular.

As used herein, the terms "optionally" or "optionally" mean that the subsequently described event or circumstance may or may not occur, and that the description includes both the occurrence and absence of the stated event or circumstance.

The term "alkyl" refers to a straight or branched saturated aliphatic hydrocarbon group consisting of carbon atoms and hydrogen atoms connected to the rest of the molecule by a single bond. "Alkyl" may have 1-10 carbon atoms, that is, "C ₁ -C ₁₀ alkyl", such as C ₁ -C ₄ alkyl, C ₁ -C ₃ alkyl, C ₁ -C ₂ alkyl, C ₃ alkyl, C ₄ alkyl, C ₃ -C ₆ alkyl. Non-limiting examples of alkyl groups include, but are not limited to, methyl, ethyl, propyl, butyl, pentyl, hexyl, isopropyl, isobutyl, sec-butyl, tert-butyl, isopentyl, 2- Methylbutyl, 1-methylbutyl, 1-ethylpropyl, 1,2-dimethylpropyl, neopentyl, 1,1-dimethylpropyl, 4-methylpentyl, 3-methylpentyl, 2-methylpentyl, 1-methylpentyl, 2-ethylbutyl, 1-ethylbutyl, 3,3-dimethylbutyl, 2,2-di Methylbutyl, 1,1-dimethylbutyl, 2,3-dimethylbutyl, 1,3-dimethylbutyl or 1,2-dimethylbutyl, or their isomers body.

The term "cycloalkyl", when used herein alone or in combination with other groups, refers to a saturated, non-aromatic monocyclic or polycyclic (such as bicyclic) hydrocarbon ring (e.g., monocyclic, such as cyclopropyl, cyclobutyl , cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl; or bicyclic, including spiro, fused or bridged systems (such as bicyclo[1.1.1]pentyl, bicyclo[2.2.1] Heptyl, bicyclo[3.2.1]octyl or bicyclo[5.2.0]nonyl, decahydronaphthyl, etc.). For example, the term "C _3-10 cycloalkyl" refers to having 3-10 ring carbon atoms ( Such as 3, 4, 5, 6, 7, 8, 9 or 10) cycloalkyl groups.

The term "3-18 membered ring", when used herein alone or in combination with other groups, refers to a ring containing 3-12 atoms. Such rings may be saturated or unsaturated (ie, contain one or more double or triple bonds). "3-12-membered ring" can cover, for example, 3-6-membered, 6-9, 9-12, 12-15-membered and 15-18-membered rings, such as 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 or 18 membered rings. In addition to the carbon atoms, 0, 1 or 2 additional heteroatoms may optionally be included in the carbocyclic ring. Examples of heteroatoms are oxygen, sulfur, and nitrogen. Those skilled in the art should understand that the 3-18 members in "3-18 membered ring" only refer to the number of carbon atoms therein. When additional heteroatoms are included, the number of heteroatoms is not counted in the number of ring atoms. For example, when it contains 1 heteroatom, a "3-18-membered ring" contains 4-19 ring atoms, of which 1 ring atom is a heteroatom and the rest are carbon atoms.

The term "halo" or "halogen" or "halo" is understood to mean a fluorine (F), chlorine (Cl), bromine (Br) or iodine (I) atom, preferably a fluorine, chlorine, bromine atom.

The term "aryl" refers to an all-carbon monocyclic or fused polycyclic (eg, bicyclic) aromatic ring group having a conjugated π electron system. For example, an aryl group may have 6-14 carbon atoms, suitably 6-10, more suitably 6 or 10. Examples of aryl groups include, but are not limited to, phenyl, naphthyl, anthracenyl, and the like.

The term "amino acid" refers to an organic compound or moiety consisting of amino and carboxyl functional groups and attached side chains, such as amino acids and their stereoisomers with the following chemical formula: H ₂ N-(CR ^a R ^b ) _t CO ₂ H; wherein, R ^a and R ^b are each independently hydrogen or any substituent, and t is an integer greater than or equal to 1, such as 1, 2, 3, 4 or 5. Substituents may be linear or branched structures. For example, R ^a and/or R ^b each independently correspond to, but are not limited to, hydrogen or side chains on naturally occurring amino acids, such as methyl, benzyl, hydroxymethyl, thiomethyl, carboxyl, carboxymethyl, Guanidinopropyl, etc. and their derivatives and protective derivatives. Amino acids include naturally occurring amino acids, unnatural amino acids, imino acids such as proline, amino acid analogs, and amino acid mimetics that function in a manner similar to naturally occurring amino acids, and also include their D and L stereoisomers form. Naturally encoded amino acids are protein amino acids known to those skilled in the art, including 20 common amino acids, namely alanine (Ala), arginine (Arg), asparagine (Asn), aspartic acid (Asp) ), cysteine (Cys), glutamine (Gln), glutamic acid (Glu), glycine (Gly), histidine (His), isoleucine (Ile), leucine (Leu) , Lysine (Lys), methionine (Met), phenylalanine (Phe), proline (Pro), serine (Ser), threonine (Thr), tryptophan (Trp), Tyrosine (Tyr) and valine (Val).

The term "moisture attractant" as used herein refers to an agent used to absorb moisture. Exemplary moisture attractants include, but are not limited to, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, glycerol polyethers, xylitol, sorbitol, propylene glycol glucoside, and sodium lactate.

The term "acid-base buffer" used herein refers to a solution used to control the pH of a solution to keep the pH within a certain range. Exemplary acid-base buffers include, but are not limited to, citrate buffer, ammonium buffer, acetate buffer, phosphate buffer, and bicarbonate buffer.

As used herein, the term "porous breathable material" refers to a material that contains internal porosity with interconnected pores to allow airflow through the material. Exemplary porous breathable materials include, but are not limited to, polyester filter wool, glass wool, rock wool, air filter cotton, and foam sponge.

The term "oxidizing disinfectant" used herein refers to a disinfectant containing oxidizing active substances, wherein exemplary oxidizing active substances include but are not limited to chlorine, hydrogen peroxide, aldehydes, peracetic acid, etc.

The term "irritant gas" used herein refers to gases that are irritating to the eyes and respiratory mucosa, and are usually toxic gases commonly encountered in the chemical industry. In this article, the irritating gas refers to the gas contained in the oxidative disinfectant, which includes but is not limited to chlorine, chlorine dioxide, hydrogen peroxide, aldehydes, peracetic acid, etc.

The terms "multilayer material A" and "multilayer material B" used herein are only used to distinguish the above two multilayer materials containing different structures, but not in terms of nature, use or order.

The terms "first base layer material", "second base layer material", "first filter layer" and "second filter layer" used herein are only used to distinguish them from other layers in the multi-layer material, and do not indicate the nature or use of the materials. or order, etc.

combination

In one aspect, the present invention relates to a composition for adsorbing and neutralizing irritating gases in an oxidative disinfectant, the composition comprising: (A) about 0.1-99 based on the total weight of the composition % by weight of biosorbent and (B) about 0.0001 to 99% by weight of moisture attractant.

In one embodiment, the composition includes: (A) about 26-46 wt% biosorbent and (B) about 44-64 wt% moisture attractant, based on the total weight of the composition. In a preferred embodiment, the composition contains: (A) about 36 wt% biosorbent and (B) about 54 wt% moisture attractant, based on the total weight of the composition.

(A)Biosorbent

In this article, a biosorbent is a biological material capable of adsorbing and neutralizing irritating gases. Exemplary biosorbents include, but are not limited to, small molecule compounds, high molecular polymers, amino acids, proteins, enzymes, etc.

In this article, neutralizing irritating gases means that the biosorbent chemically reacts with the irritating gas to form environmentally friendly substances, or the biosorbent decomposes the irritating gas into environmentally friendly substances.

In one embodiment, the biosorbent is selected from one or more of the following:

(a) Compounds containing enol structure;

(b) Compounds containing sulfhydryl groups;

(c)Amino acids;

(d) Biological enzymes.

(a) Compounds containing enol structure

The enol structure refers to a chemical moiety with an alkene, which has a hydroxyl group attached to one end of the alkene double bond, and can be represented by the following chemical formula.

Among them, the substituents R ¹ and R ² are the same or different substituents, or they are connected to form a cyclic compound with an enol structure. Exemplary enol structure-containing compounds include, but are not limited to, vitamin C, vitamin B6, vitamin B9, catechol, vinyl alcohol, acetol, stigmastenol, tocotrienol, euphorbienol, isoenol, Ascorbic acid, ascorbyl palmitate, ascorbic acid glucoside, etc.

In one embodiment, the compound containing an enol structure has reducing properties and can adsorb oxidative and irritating gases in the air and undergo redox reactions with them to form environmentally friendly products. It can remove oxidative and irritating gases in the environment without affecting the environment and human health.

In another embodiment, some enol-containing compounds (eg, vitamin C) will change color, for example, yellow, after being oxidized. Therefore, compounds containing an enol structure can act as indicators. For example, when a compound containing an enol structure turns yellow, it can be known that the content of the active ingredient (the unoxidized compound containing an enol structure) is low. It helps to remind people to timely update the compounds containing enol structure used.

In one embodiment, the compound containing an enol structure is a 3-18 membered cyclic enol compound containing 0, 1 or 2 additional heteroatoms independently selected from oxygen, sulfur, nitrogen and phosphorus and derivatives thereof substance, the ring may be optionally substituted by one or more substituents selected from the following, C _1-10 alkyl, C _3-10 cycloalkyl, aryl, aryl-C _1-4 alkyl, Wherein each alkyl, cycloalkyl, aryl group is unsubstituted or is independently selected from at least one group consisting of hydroxyl, CN, amino, acyl, carboxyl, halogen, C _1-10 alkyl, C _3-10 cycloalkyl , C _1-10 alkoxy substituent substituted. In a preferred embodiment, the compound containing an enol structure is a 3-18 membered cyclic enol compound containing 0, 1 or 2 additional heteroatoms independently selected from oxygen, sulfur and nitrogen, and derivatives thereof substance, the ring may be optionally substituted by one or more substituents selected from the following, C _1-10 alkyl, aryl, wherein each alkyl, aryl is unsubstituted or is independently substituted by at least one Substituted with a substituent selected from hydroxyl, amino, acyl, carboxyl, halogen, C _1-10 alkyl; vinyl alcohol; acetol. In a more preferred embodiment, the compound containing an enol structure is selected from one or more of the following: vitamin C, vitamin B6, vitamin B9, catechol, vinyl alcohol, acetol, stigmasterene Alcohol, tocotrienol, euphorbienol, isoascorbic acid, ascorbyl palmitate, ascorbyl glucoside and its derivatives. In a more preferred embodiment, the compound containing an enol structure is selected from one or more of the following: vitamin C, vitamin B6, and vitamin B9. In a particularly preferred embodiment, the compound containing an enol structure is vitamin C.

In one embodiment, the content of the enol structure-containing compound is about 0.01-95% by weight based on the total weight of the composition. In a preferred embodiment, the content of the enol structure-containing compound is about 1 to 50% by weight based on the total weight of the composition. In a more preferred embodiment, the content of the enol structure-containing compound is about 13.2-14.8% by weight based on the total weight of the composition. For example, about 13.2% by weight, about 13.3% by weight, about 13.4% by weight, about 13.5% by weight, about 13.6% by weight, about 13.7% by weight, about 13.8% by weight, about 14% by weight, about 14.2% by weight, about 14.4% by weight. , about 14.6% by weight, about 14.8% by weight.

If the content of compounds containing enol structures is too high, the composition will produce a large amount of ketones and organic acid compounds after the redox reaction, which will increase the pH value of the composition system and make it easy to precipitate and crystallize at low temperatures. If the content of compounds containing an enol structure is too low, the oxidative irritating gases cannot be completely neutralized, and the discoloration of the mask is not obvious and it cannot function as an indicator.

(b) Compounds containing thiol groups

Thiol refers to the -SH group. The sulfhydryl group is reducing, so compounds containing sulfhydryl groups can be oxidized. Therefore, thiol-containing compounds can be used to adsorb oxidative and irritating gases in the air and undergo redox reactions with them to form environmentally friendly products. It can remove oxidative and irritating gases in the environment without affecting the polluted environment and human health. In addition, mercapto compounds have a strong affinity for heavy metal ions (such as Cu ²⁺ , Pb ²⁺ , Ag ^+, etc.) (its affinity is much higher than that of ethylenediaminetetraacetic acid EDTA), allowing it to combine with the above heavy metal ions to form Metal sulfides precipitate, thereby removing heavy metal ions from the environment. Cu ²⁺ is known to accelerate the oxidation of vitamin C, so compounds containing thiol groups can also remove heavy metal ions in the environment and significantly improve the stability of compounds containing enol structures.

In one embodiment, the thiol-containing compound is selected from the group consisting of cysteine, thioglycolic acid, dimercaprol, sodium dimercaprol, tiopronin, disodium dimercaptosulfate, cysteamine, penicillamine , lipoic acid, captopril, glutathione, alpha-lipoic acid, dithiothreitol and combinations thereof. In a preferred embodiment, the thiol-containing compound is selected from the group consisting of N-acyl-cysteine, N-alkyl-cysteine, dimercaprol, disodium dimercapto, and dithiothreose Alcohols and their combinations. In a more preferred embodiment, the thiol-containing compound is selected from the group consisting of N-acetyl-L-cysteine, N-methyl-L-cysteine, N-ethyl-L-cysteine Acid, dimercaprol, disodium dimercapto, dithiothreitol and combinations thereof. In a particularly preferred embodiment, the thiol-containing compound is N-acetyl-L-cysteine.

In one embodiment, the thiol-containing compound is present in an amount of about 0.0001 to 99% by weight, based on the total weight of the composition. In a preferred embodiment, the thiol-containing compound is present in an amount of about 0.1 to 20% by weight, based on the total weight of the composition. In a more preferred embodiment, the thiol-containing compound is present in an amount of about 3.0 to 3.4% by weight, based on the total weight of the composition. For example, about 3.0% by weight, about 3.02% by weight, about 3.06% by weight, about 3.1% by weight, about 3.12% by weight, about 3.16% by weight, about 3.20% by weight, about 3.23% by weight, about 3.26% by weight, about 3.28% by weight. , about 3.3% by weight, about 3.32% by weight, about 3.34% by weight, about 3.38% by weight, about 3.4% by weight. For example, about 1% by weight, about 1.125% by weight, and about 2.28% by weight.

Since sulfhydryl-containing compounds themselves have a special odor, such as a garlic-like sulfide odor, too high a content of sulfhydryl-containing compounds can easily irritate the eyes and respiratory mucosa and should not be used in production practice, such as in daily necessities. An excessively low content of thiol-containing compounds makes the composition of the present invention insufficiently reducible, unable to adsorb and neutralize sufficient oxidative irritating gases, unable to reduce the activity of proteins, and is also unfavorable to the stability of compounds containing enol structures. .

(c)Amino acids

Under alkaline conditions, the primary amino groups in amino acids can react with aldehydes to obtain Schiff base compounds. Therefore, adding amino acids to the composition of the present invention can effectively adsorb and neutralize aldehyde-based compounds in the air, thereby reducing the damage caused by aldehyde compounds to the human body.

In one embodiment, the amino acid is selected from the group consisting of alanine, valine, leucine, isoleucine, methionine, proline, tryptophan, serine, tyrosine, cysteine Acid, phenylalanine, asparagine, glutamine, threonine, aspartic acid, glutamic acid, lysine, arginine, histidine, glycine and combinations thereof. In a preferred embodiment, the amino acid is selected from the group consisting of glycine, glutamic acid and combinations thereof. In a more preferred embodiment, the amino acid is glycine.

In one embodiment, the amino acid is present in an amount of about 0.0001-95% by weight, based on the total weight of the composition. In a preferred embodiment, the amino acid is present in an amount of about 0.0001 to 85% by weight, based on the total weight of the composition. In a more preferred embodiment, the amino acid is present in an amount of about 20-25% by weight, based on the total weight of the composition. For example, about 20% by weight, about 20.5% by weight, about 21% by weight, about 21.1% by weight, about 21.4% by weight, about 21.8% by weight, about 22% by weight, about 22.3% by weight, about 22.6% by weight, about 23% by weight, About 23.5% by weight, about 24% by weight, about 24.1% by weight, about 24.5% by weight, about 25% by weight.

An amino acid content that is too high will crystallize and precipitate at low temperatures, while an amino acid content that is too low is not enough to neutralize the irritating gases produced by the volatilization of aldehyde disinfectants.

(d) Biological enzymes

Biological enzymes refer to catalytic organic substances produced by living cells, which can specifically catalyze the transformation of substances. Different types of biological enzymes can be selected and used according to actual production or work purposes. For example, in order to absorb and break down hydrogen peroxide, catalase is used in the actual work process.

In one embodiment, the biological enzyme is selected from the group consisting of catalase and horseradish peroxidase. In a preferred embodiment, the biological enzyme is catalase. An exemplary catalase may be food-grade catalase with a specification of 50,000 U/g.

In one embodiment, the biological enzyme is present in an amount of about 0.0000001-20% by weight based on the total weight of the composition. In a preferred embodiment, the biological enzyme is present in an amount of about 0.02-0.2% by weight based on the total weight of the composition.

Too high or too low biological enzyme content will reduce the speed of hydrogen peroxide catalytic decomposition.

(B) Moisture attractant

Hygroscopic agents are agents used to absorb moisture. Exemplary moisture attractants include, but are not limited to, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, glycerol polyether, xylitol, sorbitol, propylene glycol glucoside, sodium lactate, and the like.

In this article, the hygroscopic agent in the composition of the present invention can absorb moisture in the air or additional added moisture, so that the composition becomes a moist or solution state, thereby dissolving the biosorbent in the moisture, thereby increasing the biosorbent The contact area with the adsorbed gas (such as chlorine, hydrogen peroxide, peracetic acid, aldehyde compounds, etc.) improves the efficiency of gas adsorption.

In one embodiment, the moisture attracting agent is selected from the group consisting of diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, glycerol polyether, xylitol, sorbitol, propylene glycol glucoside, and sodium lactate. and combinations thereof. In a preferred embodiment, the moisture attractant is selected from the group consisting of glycerin, propylene glycol and combinations thereof. In a more preferred embodiment, the moisture attracting agent is glycerol.

In one embodiment, the moisture attractant is present in an amount of about 0.0001-99% by weight. In a preferred embodiment, the moisture attractant is present in an amount of about 44 to 64% by weight. In a more preferred embodiment, the content of the moisture attractant is about 50-54% by weight, such as about 51% by weight, about 51.3% by weight, about 51.8% by weight, about 52% by weight, about 52.2% by weight, about 52.6% by weight. % by weight, about 53% by weight, about 53.5% by weight, about 53.8% by weight, about 54% by weight.

Excessively high moisture attractant content will cause the composition to absorb a large amount of water, causing a sudden increase in liquid volume, reducing the breathability of the composition, thereby increasing the breathability resistance of the composition. For example, when a moisture absorbing agent is used in a protective mask, an excessively high moisture absorbing agent content will lead to a reduction in the breathability of the composition, thereby reducing the comfort of the protective mask. In addition, an excessively high moisture-drawing agent content will increase the viscosity of the composition, making it difficult to atomize and spray the composition solution. Too low a moisture attractant content cannot form a sufficient aquifer to effectively absorb water-soluble irritating gases.

(C)Other ingredients

The composition of the present invention also contains other components according to the needs of the actual situation and the optimal working environment required by the biosorbent. For example, to increase the shelf life of the composition, the compositions of the present invention may include a preservative. For another example, in order to make the biosorbent (such as amino acid) more susceptible to adsorbing aldehyde-based compounds, the composition of the present invention can include an acid-base buffer, wherein the acid-base buffer can adjust the working environment of the composition to be alkaline or alkaline. acidic.

In one embodiment, the composition further includes at least one of the following ingredients, based on the total weight of the composition:

(e) about 0.00000001-1% by weight of preservative;

(f) About 0.00001-90% by weight of acid-base buffer;

(g) about 0.000001-5% by weight antioxidant;

(h) about 0-1% by weight of emulsifier;

(i) About 0-20% by weight liquid sealant;

(j) about 0-20% by weight of protein coagulant;

(k) about 0-20% by weight of plant extracts;

(l) About 0.0001-2% by weight of odor masking agent.

(e) Preservatives

Preservatives refer to components that increase the stability of the compositions of the present invention.

In one embodiment, the preservative is selected from the group consisting of parahydroxybenzoic acid preservatives (parabens), benzoic acid preservatives, sorbic acid preservatives, benzalkonium bromide, chlorhexidine acetate, ortho Phenylphenols, hexamethyleneguanidine hydrochloride preservative, dehydroacetic acid, sodium diacetate, polylysine, sodium lactate, natamycin. In a preferred embodiment, the preservative is selected from paraben-based preservatives and sorbic acid-based preservatives. In a more preferred embodiment, the preservative is a paraben catalyst. In a specific embodiment, the preservative is ethylparaben (also known as ethylparaben).

In one embodiment, adding a preservative to the composition of the present invention can improve the stability of the composition and inhibit the growth of microorganisms. Examples of microorganisms that can inhibit growth include bacteria and fungi. The bacteria may be, for example, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, hemolytic Streptococcus, etc.

In one embodiment, the preservative is present in an amount of about 0.00000001-1% by weight, based on the total weight of the composition. In a preferred embodiment, the preservative is present in an amount of about 0.001 to 0.5% by weight, based on the total weight of the composition. In a more preferred embodiment, the preservative is present in an amount of about 0.05 to 0.3% by weight, based on the total weight of the composition. For example, about 0.05% by weight, about 0.1% by weight, about 0.15% by weight, about 0.2% by weight, 0.25% by weight, and about 0.3% by weight.

Excessive preservative content will increase the toxicity of the composition and easily cause harm to the human body, making it difficult for the composition of the present invention to be used in daily necessities. Too low a preservative content cannot significantly improve the stability of the composition, and the composition is susceptible to microbial contamination and is not suitable for long-term storage.

(f)Acid-base buffer

Acid-base buffer refers to a mixed solution composed of weak acid and its salts or weak base and its salts. It can offset and reduce the influence of external strong acid or strong base on the pH of the solution to a certain extent, thereby maintaining the pH value of the solution relatively Stablize.

In the present invention, according to the needs of the biosorbent and other components for the working environment, different acid-base buffers are selected to provide a suitable working environment for the biosorbent and other components, improve the adsorption of the biosorbent and neutralize stimulation. Efficiency of sexual gas.

In one embodiment, the acid-base buffer is selected from the group consisting of sodium bicarbonate buffer, phosphate buffer, sodium acetate, and sodium citrate buffer. In a preferred embodiment, the acid-base buffer is selected from phosphate buffer. In a more preferred embodiment, the acid-base buffer is selected from sodium dihydrogen phosphate-disodium hydrogen phosphate buffer. In another preferred embodiment, the acid-base buffer is sodium bicarbonate buffer.

In one embodiment, the acid-base buffer used in the present invention can adjust the pH of the composition system to about 3-10. In a preferred embodiment, the acid-base buffer used in the present invention can adjust the pH of the composition system to about 5.0-6.2. In a more preferred embodiment, the acid-base buffer used in the present invention can adjust the pH of the composition system to about 5.8 (the average pH of the skin). A pH value that is too low is not conducive to the Schiff base reaction of amino acids and aldehyde compounds, and a pH value that is too high will cause the stability of compounds containing enol structures (such as vitamin C) to decrease.

In one embodiment, the acid-base buffering agent is present in an amount of about 0.00001-90% by weight, based on the total weight of the composition. In a preferred embodiment, the acid-base buffering agent is present in an amount of about 0.01 to 5% by weight, based on the total weight of the composition. In a more preferred embodiment, the acid-base buffering agent is present in an amount of about 1.0-2.5% by weight, based on the total weight of the composition. For example, about 1.0% by weight, about 1.3% by weight, about 1.5% by weight, about 1.8% by weight, about 2.0% by weight, about 2.2% by weight, about 2.5% by weight.

Excessively high acid-base buffer content will increase the osmotic pressure of the composition and enhance the ionic strength, which is not conducive to the enzymatic reaction (such as the enzymatic reaction of catalase). Too low an acid-base buffer content is not conducive to the conditions required for enzymatic reactions (such as catalase) and is not conducive to the stable storage of the composition of the present invention.

(g)Antioxidants

Antioxidants are substances that can delay, reduce, inhibit or prevent the oxidation of oxidizable substances.

In the present invention, the biosorbent may be an enol structure-containing compound or a sulfhydryl group-containing compound with reducing properties. Therefore, in order to extend the storage time of the composition, antioxidants can be added to the composition to improve the durability of the composition.

In one embodiment, the antioxidant is selected from the group consisting of sodium metabisulfite, sodium bisulfite, sodium thiosulfate, vitamin E, L-ascorbyl palmitate, alkyl gallate, butylated hydroxyanisole, and butylated hydroxytoluene. In a preferred embodiment, the antioxidant is sodium metabisulfite.

In one embodiment, the antioxidant is present in an amount of about 0.000001-5% by weight, based on the total weight of the composition. In a preferred embodiment, the antioxidant is present in an amount of about 0.001 to 0.04% by weight, based on the total weight of the composition. In a more preferred embodiment, the acid-base buffering agent is present in an amount of about 0.01 to 0.03% by weight, based on the total weight of the composition. For example, about 0.01% by weight, about 0.013% by weight, about 0.015% by weight, about 0.017% by weight, about 0.02% by weight, about 0.023% by weight, about 0.025% by weight, about 0.027% by weight, about 0.029% by weight, about 0.03% by weight. .

Excessively high antioxidant content will exceed the upper limit of the amount of food additives, which is not conducive to the application of the composition of the present invention in daily necessities. Antioxidant content that is too low is insufficient to prevent enol compounds from being oxidized.

(h) Emulsifier

Emulsifier refers to a class of compounds that can mix two or more mutually immiscible components to form a stable emulsion.

In the present invention, when an organic compound (such as ethyl hydroxyphenyl ester) is selected as the preservative, its solubility in water is poor. Therefore, in order to improve the solubility of the preservative in water so that the composition of the present invention can have a longer shelf life, an emulsifier is added to the composition.

In one embodiment, the emulsifier is selected from polysorbate, triethanolamine, sorbitan oleate (Span), alkylphenol polyoxyethylene ether (OP), glyceryl stearate, lauryl Sodium sulfonate. In a preferred embodiment, the emulsifier is polysorbate. In a specific embodiment, the emulsifier is polysorbate-80 (Tween-80).

In one embodiment, the emulsifier is present in an amount of from about 0 to 1% by weight, based on the total weight of the composition. In a preferred embodiment, the emulsifier is present in an amount of about 0.001 to 0.01% by weight, based on the total weight of the composition. For example, about 0.001% by weight, about 0.002% by weight, about 0.003% by weight, about 0.004% by weight, about 0.005% by weight, about 0.006% by weight, about 0.007% by weight, about 0.008% by weight, about 0.009% by weight, about 0.01% by weight. .

Excessive emulsifier content will affect the preservative effect of the preservative. Too low emulsifier content is not conducive to the dissolution of preservatives. For example, when the composition of the present invention is stored under low temperature conditions, the preservative may precipitate from the composition system, so the preservative cannot effectively play a preservative role.

In one embodiment, when the preservative used is a water-soluble preservative, no emulsifier may be added to the composition.

(i) Liquid sealant

In the present invention, the composition of the present invention is easily in contact with air during storage and retrieval, forming an aqueous solution, and the compounds containing an enol structure and the compounds containing a thiol structure in the composition are easily oxidized by the air above the solution. Therefore, in order to reduce the losses caused by the above reasons to the composition and enhance the stability of the composition of the present invention, a liquid sealing agent is added to the solution of the composition to isolate the composition of the present invention from air.

In one embodiment, the liquid sealing agent is selected from edible oil, mineral oil, silicone oil, dimethicone and liquid paraffin (paraffin oil). In a preferred embodiment, the liquid sealing agent is liquid paraffin.

In one embodiment, the liquid sealant is present in an amount of about 0-20% by weight based on the total weight of the composition. In a preferred embodiment, the liquid sealant is present in an amount of about 1 to 10% by weight based on the total weight of the composition. For example, about 1% by weight, about 2% by weight, about 3% by weight, about 4% by weight, about 5% by weight, about 6% by weight, about 7% by weight, about 8% by weight, about 9% by weight, about 10% by weight. .

The purpose of using a liquid sealant is to prevent the composition from being oxidized by air when it is taken out when the composition is stored in a rigid container (such as a stainless steel barrel). Excessively high liquid sealing agent content will cause low-polarity substances in the composition (such as fat-soluble preservatives) to dissolve in the liquid sealing agent, affecting the performance of the composition. Too low a liquid sealant content will prevent the liquid sealant from completely covering the surface of the composition. When packaging materials with air-isolating functions (such as vacuum bottles and ampoules with a piston AS plastic at the bottom) are used for retail packaging, liquid sealing agent does not need to be added.

(j)Protein coagulant

Usually preservatives are only effective against microorganisms with cellular structures such as bacteria and fungi, but are not effective against microorganisms such as viruses that are composed of nucleic acid and protein shells. Therefore, adding a protein coagulant to the composition of the present invention can destroy the spatial conformation of the protein, prompting the protein shell of the virus to coagulate and lose biological activity, thereby possibly producing an antiviral effect.

In one embodiment, the protein coagulant is selected from sodium sulfate, ammonium sulfate, picric acid, phosphotungstic acid, phosphomolybdic acid, tannic acid, trichloroacetic acid, sulfosalicylic acid, urea, berberine, Tetrandrine, guanidine hydrochloride, gluconic acid and its salts, glucono-delta-lactone and combinations thereof. In a preferred embodiment, the protein coagulant is glucono-delta-lactone.

In one embodiment, the protein coagulant is present in an amount of about 0-20% by weight, based on the total weight of the composition. In a preferred embodiment, the protein coagulant is present in an amount of about 0.0001 to 20% by weight, based on the total weight of the composition. In a more preferred embodiment, the protein coagulant is present in an amount of about 0.1-0.3% by weight, such as about 0.1% by weight, about 0.13% by weight, about 0.15% by weight, about 0.18% by weight, about 0.18% by weight, based on the total weight of the composition. 0.2% by weight, about 0.25% by weight, about 0.3% by weight.

An excessively high content of protein coagulant will increase the skin and mucous membrane irritation of the composition and produce excessive astringency and astringency. Protein coagulant levels that are too low can reduce the bioactive ability of the antiviral protein coat of the composition. In addition, lower-content protein coagulants are less irritating and can be used for respiratory aerosol inhalation.

(k)Plant extracts

Usually food preservatives are only effective against microorganisms with cellular structures such as bacteria and fungi, but not against viruses. The addition of plant extracts with potential antimicrobial (especially antiviral) activity to the compositions of the present invention may enhance the overall antimicrobial effectiveness of the compositions.

In one embodiment, the main component molecules of the plant extract contain at least 4 hydroxyl groups, which are selected from the group consisting of chlorogenic acid, luteolin, luteolin, and luteolin-7-O-β-D- Glucuronide and a plant extract of one of the proanthocyanidin components. The proanthocyanidin component can be selected from, for example, the leaves of Eucommia ulmoides, Lonicera japonica (honeysuckle), Lonicera erythricum, flowers of Honeysuckle or Lonicera tomentosa, Lonicera vine, and English hawthorn. , cauliflower, cauliflower root, cabbage stems, fenugreek, cantaloupe, capsules, sweet potato leaves, small coffee, medium coffee and large coffee seeds, burdock leaves and roots, peanut shells, Mignonette, Lianqiancao, Beiliujinu, Qinglan, Brocade Lantern, Naked Flower Purple Pearl, Kudianzi, Grape Seed. In a preferred embodiment, the plant extract is grape seed extract (the main component of which is proanthocyanidins).

In one embodiment, the plant extract is present in an amount of about 0-20% by weight, based on the total weight of the composition. In a preferred embodiment, the plant extract is present in an amount of about 0.0001 to 20% by weight, based on the total weight of the composition. In a more preferred embodiment, the plant extract is present in an amount of about 0.5-0.9% by weight, based on the total weight of the composition. For example, about 0.5% by weight, about 0.6% by weight, about 0.7% by weight, about 0.8% by weight, and about 0.9% by weight.

Plant extracts are usually brown, ultraviolet-blue-violet light-absorbing substances that can act as sunscreens. Too high a content of plant extracts will make the composition too dark, thus affecting its aesthetics. Too low a content of plant extracts will reduce the light absorption properties of the composition, which is not conducive to the stable storage of compounds containing enol structures that are sensitive to light, and will result in weakened antimicrobial activity. However, reducing the content of plant extracts can reduce irritation, making it suitable for respiratory aerosol inhalation.

(l) Odor masking agent

Compounds containing sulfhydryl groups often have a sulfide odor and may cause an unpleasant smell. Using an odor masking agent with a fresh scent can better cover up the odor.

In one embodiment, the odor masking agent may be a fruity flavor. In one embodiment, the odor masking agent is selected from volatile oils from tangerine peels of the family Rutaceae, such as lemon oil, whose main component is limonene, and its minor components also include pinene, myrcene, terpinene, etc. Among them, lemon oil-containing botanicals (such as tangerine peel, traditional Chinese medicine pieces) and eucalyptus, lemon and pinole enteric-coated soft capsules (National Drug Approval No. H20052401) can improve the ciliary movement of tracheal mucosa, promote the secretion of respiratory glands, reduce phlegm, and promote self-purification of the respiratory tract. Pharmacological effects: It is a classic auxiliary medicine for respiratory diseases.

In one embodiment, the odor masking agent is present in an amount of about 0.0001-2% by weight, based on the total weight of the composition. In a preferred embodiment, the odor masking agent is present in an amount of about 0.01 to 0.9% by weight, based on the total weight of the composition. In a more preferred embodiment, the odor masking agent is present in an amount of about 0.2 to 0.5% by weight, based on the total weight of the composition. For example, about 0.2% by weight, about 0.3% by weight, about 0.4% by weight, and about 0.5% by weight.

Excessive odor masking agent content will affect the stability of other ingredients and may cause irritation and other adverse reactions. Levels that are too low may not be enough to mask the odor of sulfhydryl-containing compounds.

Many studies have shown that tannic acid, chlorogenic acid, luteolin, and persimmon tannin have antiviral effects. However, the stability of the above substances is poor, thus limiting their commercial value. This is mainly because the above-mentioned substances are polyphenols containing polyhydroxyl structures, which are easily oxidized and hydrolyzed by metal ions and air and become ineffective. The composition of the present invention contains a relatively high concentration of compounds containing enol structures and compounds containing sulfhydryl groups, which can have a good protective effect on the above-mentioned polyphenols. Therefore, the combination of the composition of the present invention and the above-mentioned substances It also helps the above-mentioned substances to realize their commercial value.

In addition, it has been reported that the isoelectric point of the S protein of 2019-nCoV is 6.24, the isoelectric point of S1/S2/His is 4.41-5.87, and the isoelectric point of the key binding protein of hACE2/His is 5.19-6.11 through protein models. (average pH 5.60). The pH value of the composition of the present invention is set to 5.6-6.0 (preferably pH is 5.8). During use, the pH will gradually increase (when the composition is exposed to the air, the _CO2 content will gradually decrease) , the pH of the composition will slowly rise to near the isoelectric point of the S protein, thereby precipitating the protein. Therefore, the composition of the present application may have the effect of inhibiting the activity of viral surface proteins.

In addition, it is known that the sulfhydryl structure in sulfhydryl-containing compounds can also act on the disulfide bonds of proteins, thereby destroying the protein conformation and reducing the viscosity of sputum. N-acetylcysteine aerosol inhalation has been regulated by European and Chinese drug regulators. Approved by the bureau for the treatment of phlegm (such as: acetylcysteine solution for inhalation, National Drug Approval H20150548, JX20020133, ZAMBON S.p.A.). Therefore, since the composition of the present invention contains a sulfhydryl compound, it can also achieve a long-lasting protein activity inhibition effect.

aqueous solution

In one embodiment, the composition is present in an amount of about 30-80% by weight, based on the total weight of the aqueous solution. In a preferred embodiment, the composition is present in an amount of about 56-76% by weight, based on the total weight of the aqueous solution. In a more preferred embodiment, the composition is present in an amount of about 66% by weight, based on the total weight of the aqueous solution. For example, about 30% by weight, about 35% by weight, about 40% by weight, about 43% by weight, about 45% by weight, about 50% by weight, about 55% by weight, about 60% by weight, about 63% by weight, about 65% by weight. , about 66% by weight, about 67% by weight, about 70% by weight, about 76% by weight, about 75% by weight.

In the aqueous solution of the present invention, an appropriate water content is conducive to the composition of the present invention achieving its technical effects, such as adsorbing and neutralizing irritating gases in oxidizing disinfectants, purifying the air, inhibiting biological protein activity, etc. Excessively high water content results in a low content of the composition, which is insufficient to achieve the technical effects of the present invention. Too low water content is not conducive to the full dissolution of the components, so that each component of the composition cannot be fully contacted with the adsorbed gas, so it cannot effectively adsorb and neutralize the irritating gases in the oxidizing disinfectant, and is not conducive to other Realization of technical effects.

Compared with the vitamin C aqueous solution, the composition aqueous solution of the present invention can absorb and neutralize irritating gases (such as irritating gases in oxidative disinfectants) more effectively, and the adsorption efficiency can be significantly improved.

base material

In another aspect, the invention relates to a substrate, characterized in that it contains a composition of the invention.

In one embodiment, the substrate is used to adsorb and neutralize irritating gases in oxidative disinfectants.

In one embodiment, the composition of the invention is adsorbed onto the substrate.

The base material of the present invention refers to a material product, such as sheet, metal plate, non-woven fabric, glass fiber, etc. Depending on the needs of the working environment, different materials can be attached to the surface of the substrate. For example, in order to absorb fine particles in the air, such as pollen, dust, etc., activated carbon can be attached to the surface of the substrate. For another example, in order to adsorb acidic gases in the air, a weakly alkaline compound, such as sodium bicarbonate, can be attached to the surface of the substrate. For another example, in order to adsorb oxidizing gases in the air, such as chlorine, reducing compounds, such as compounds containing enol structures or compounds containing thiol groups, may be attached to the surface of the substrate.

In addition, different types of materials can be used as the substrate depending on the purpose of the substrate. For example, if used in an air purifier, the substrate may be a metal mesh. For another example, if used for oral protective equipment, the base material can be a non-woven fabric in a mask or a filter membrane in a gas mask.

In one embodiment, the substrate is selected from the group consisting of non-woven cloth, metal mesh, fiberglass, cotton cloth, linen cloth, and filter cotton. In a preferred embodiment, the substrate is non-woven fabric.

Multi-layer material A

In another aspect, the present invention relates to a multi-layer material A, characterized in that the multi-layer material A includes: the base material of the present invention as the base material; and the activated carbon layer as the first filter layer.

base material

In the present invention, in one embodiment, the base material as the base material is selected from non-woven cloth, metal mesh, glass fiber, cotton cloth, linen cloth, and filter cotton. In a preferred embodiment, the substrate is non-woven fabric. The base material is attached with the composition of the present invention and can be used to adsorb and neutralize irritating gases. The irritating gases can be, for example, volatile gases in oxidizing disinfectants, such as chlorine in chlorine-containing disinfectants, The volatilized hydrogen peroxide in hydrogen peroxide disinfectants or the volatilized peracetic acid in peracetic acid-containing disinfectants. For another example, the irritating gas may be an aldehyde-based compound volatilized in a disinfectant containing an aldehyde-based compound.

activated carbon layer

In the present invention, the multi-layer material A also includes an activated carbon layer as the first filter layer, where the activated carbon layer is used to adsorb peracetic acid, a volatile gas in the air, but does not have the effect of neutralizing peracetic acid.

Second filter layer

In a preferred embodiment, the multi-layer material A of the present invention further includes a second filter layer between the base material and the first filter layer.

According to actual work requirements, in addition to adsorbing and neutralizing irritating gases, in order to simultaneously adsorb dust or fine particles in the air, a second filter is also included between the base material of the multi-layer material A of the present invention and the first filter layer. layer.

Depending on the purpose of the second filter layer, different types of materials can be used as the second filter layer. For example, if used in an air purifier, the substrate may be a metal mesh. For another example, if used for oral protective equipment, the base material can be a non-woven fabric in a mask or a filter membrane in a gas mask.

In a preferred embodiment, the second filter layer is selected from the group consisting of non-woven cloth, metal mesh, glass fiber, cotton cloth, linen cloth, and filter cotton. In a preferred embodiment, the second filter layer is non-woven fabric. In a more preferred embodiment, the second filter layer is melt-blown non-woven fabric.

Multi-layer material B

In another aspect, the present invention relates to a multi-layer material B, characterized in that the multi-layer material B includes: the base material of the present invention as a first base material; an intermediate isolation layer; and a second base material.

first base material

In the present invention, the first base material is the base material of the present invention, wherein the base material is as defined above.

middle isolation layer

In the present invention, the middle isolation layer is composed of a porous breathable material that is not wetted by water, and is used to isolate the first base material and the second base material so that the two base materials can work in different environments.

Due to the existence of the intermediate isolation layer, the first base layer material and the second base layer material have different working environments, for example, the pH of the two is different. For another example, the temperatures of the two are different. For another example, the humidity of the two is different.

In one embodiment, the middle isolation layer includes a porous breathable material that is not wetted by water. The porous breathable material is selected from the group consisting of polyester filter cotton, glass wool, rock wool, air filter cotton, and foam sponge. In a preferred embodiment, the porous breathable material is polyester filter cotton. In a specific embodiment, the porous breathable material is an ethylene vinyl acetate (EVA) breathable sponge.

In one embodiment, the thickness of the intermediate isolation layer is about 0.1-15 mm. In a preferred embodiment, the thickness of the intermediate isolation layer is about 3 mm.

second base material

In the present invention, the second base material includes biological enzymes, moisture absorbing agents, preservatives, and acid-base buffers, wherein the types of biological enzymes, moisture absorbing agents, acid-base buffers, and second base materials are as defined above.

In a preferred embodiment, the biological enzyme is catalase.

In the second base material, catalase is used to adsorb and decompose the volatile gas hydrogen peroxide.

In a preferred embodiment, since the biosorbent in the first base material and the catalase in the second base material need to work under different pH conditions, they can fully exert their respective adsorption and neutralization of irritating gases. Therefore, an intermediate isolation layer is provided between the first base material and the second base material, which can effectively isolate the components in the two materials. Moreover, the middle isolation layer uses a porous breathable material that is not wetted by water. Gas can still pass through the middle isolation layer smoothly and be further adsorbed and neutralized by the active ingredients in the second base material.

Face mask

In yet another aspect, the present invention relates to a mask comprising the base material, multi-layer material A or multi-layer material B of the present invention, wherein the base material, multi-layer material A and multi-layer material B are as defined above.

Preparation

The present invention also relates to a method for preparing the mask of the present invention, which includes the following steps:

(1) Preparing the composition of the present invention;

(2) Evenly infiltrate the composition obtained in step (1) on the surface of the first base material;

(3) Drying the base material obtained in step (2) under a protective gas atmosphere;

Optionally, also include the following steps:

(4) Evenly mix biological enzymes, moisture attractants, preservatives and acid-base indicators to obtain a composition;

(5) Evenly infiltrate the composition obtained in step (4) on the surface of the second base material;

(6) Drying the base material obtained in step (5) under a protective gas atmosphere;

(7) Sewing the first base material to the first filter layer, optionally to the second filter layer; or

(8) Sew the first base layer material, the second base layer material and the middle isolation layer.

The types and contents of the active ingredients or other ingredients in the first base layer material, the second base layer material, the second filter layer, the first filter layer, and the intermediate isolation layer are as defined above.

In one embodiment, the protective gas used in step (3) and step (5) is selected from nitrogen, helium, neon and carbon dioxide. In a preferred embodiment, the protective gas used in step (3) and step (5) is nitrogen. The protective gases used in step (3) and step (6) may be the same or different.

In one embodiment, the drying temperature in step (3) and step (6) is about 50-80°C or room temperature. In a preferred embodiment, the drying temperature in step (3) and step (6) is about 60°C.

On the other hand, the present invention also relates to a method for quickly preparing the mask of the present invention, which includes the following steps:

(1) Provide the composition solution of the present invention;

(2) Spray the composition liquid of step (1) onto the inside and/or outside of the mask by spraying.

In one embodiment, the composition solution of step (1) is stored in a spray bottle as described in Figure 8.

In one embodiment, in step (2), the composition of step (1) is sprayed via a spray bottle as shown in FIG. 8, see FIG. 9 for the spraying process.

In one embodiment, the composition spraying position is about 5-10 cm above the mask. For example, about 5cm, about 6cm, about 7cm, about 8cm, about 9cm, about 10cm.

In one embodiment, the volume of the composition solution sprayed in step (2) is about 3.2 mL.

In a preferred embodiment, spray the inner and outer sides of the mask about 15-20 times to complete the spraying of the composition solution. In a more preferred embodiment, the inner and outer sides of the mask are sprayed about 17-19 times to complete the spraying of the composition solution. For example, about 15 times, about 16 times, about 17 times, about 18 times, about 19 times, and about 20 times.

The stability of the composition of the present invention and its ability to adsorb and neutralize irritating gases in oxidizing disinfectant solutions

The ability of the composition of the present invention to adsorb and neutralize irritating gases in oxidizing disinfectant solutions

The ability of the composition of the present invention to neutralize irritating gases in the oxidizing disinfectant solution is tested by the following method A.

Method A

(1) Prepare disinfectant aqueous solution;

(2) Prepare an aqueous solution of the composition of the present invention;

(3) Titrate the aqueous composition solution of step (2) using the aqueous disinfectant solution of step (1);

(4) Use a titration indicator, determine the end point of the titration based on the color change of the indicator, and determine the neutralizing ability of the composition based on the volume of the disinfectant aqueous solution consumed at the end point of the titration.

In one embodiment, the ability of the composition of the present invention to adsorb and neutralize irritating gases in oxidative disinfectants is determined by the method described above.

In a preferred embodiment, the adsorption of chlorine gas in the disinfectant by the composition of the present invention is determined by titration of the aqueous solution of the composition of the present invention with trichloroisocyanuric acid disinfectant, sodium hypochlorite disinfectant and chlorine dioxide disinfectant aqueous solution. and ability. In another preferred embodiment, the ability of the composition of the present invention to adsorb and neutralize hydrogen peroxide in the disinfectant is determined by titration of an aqueous solution of the composition of the present invention with a hydrogen peroxide wash solution. In yet another preferred embodiment, the adsorption and neutralization ability of the composition of the present invention on the peracetic acid in the disinfectant is determined by titration of the aqueous solution of the composition of the present invention with an oxyacetic acid disinfectant solution.

According to the type of irritating gas to be measured, use the corresponding titration indicator accordingly. For example, when titrating chlorine-containing disinfectants, use chlorine test paper as a titration indicator. For another example, when titrating hydrogen peroxide disinfectant, use hydrogen peroxide test paper as a titration indicator. For another example, when titrating peracetic acid disinfectant, use peracetic acid test paper as a titration indicator.

Optionally, a secondary indicator is used in determining the titration end point. For example, chlorine test paper is used as an auxiliary indicator to help determine the titration endpoint of hydrogen peroxide and peracetic acid disinfectants.

In a specific embodiment, the ability of the composition of the present invention to neutralize irritating gases in the oxidative disinfectant solution is tested by the following method A1.

Method A1

(1) Prepare disinfectant solution with a concentration of 1000ppm (1000mg/L);

(2) Prepare an aqueous composition solution of the present invention, wherein the content of the active ingredient (enol structure-containing compound and/or thiol structure-containing compound and/or amino acid) in the composition aqueous solution is about 2-8% by weight;

(3) Use the disinfectant solution obtained in step (1) to titrate 1 mL of the composition aqueous solution in step (2), and record the volume of disinfectant solution consumed at the end point of the titration.

In one embodiment, the trichloroisocyanuric acid aqueous solution is prepared by the above method to perform a titration experiment. At the end point of the titration, the volume of the trichloroisocyanuric acid aqueous solution consumed by the titration is about 5-50 mL. In a preferred embodiment, the trichloroisocyanuric acid aqueous solution is prepared by the above method to perform a titration experiment. At the titration end point, the volume of the trichloroisocyanuric acid aqueous solution consumed by the titration is about 10-30 mL.

In one embodiment, the sodium hypochlorite disinfectant aqueous solution is prepared by the above method to perform a titration experiment. At the titration end point, the volume of the sodium hypochlorite disinfectant aqueous solution consumed by the titration is about 5-50 mL. In a preferred embodiment, the sodium hypochlorite disinfectant aqueous solution is prepared by the above method for a titration experiment. At the end point of the titration, the volume of the sodium hypochlorite disinfectant aqueous solution consumed by the titration is about 10-30 mL.

In one embodiment, a chlorine dioxide disinfectant aqueous solution is prepared by the above method to perform a titration experiment. At the end point of the titration, the volume of the chlorine dioxide disinfectant aqueous solution consumed by the titration is about 50-150 mL. In a preferred embodiment, the sodium hypochlorite disinfectant aqueous solution is prepared by the above method for a titration experiment. At the end point of the titration, the volume of the sodium hypochlorite disinfectant aqueous solution consumed by the titration is about 70-130 mL.

In one embodiment, the hydrogen peroxide wash solution is prepared by the above method to perform a titration experiment. At the end point of the titration, the volume of hydrogen peroxide wash solution consumed by the titration is about 0.08-1 mL. In a preferred embodiment, the hydrogen peroxide wash solution is prepared by the above method to perform a titration experiment. At the end point of the titration, the volume of hydrogen peroxide wash solution consumed by the titration is about 0.08-0.5 mL.

In one embodiment, the peracetic acid disinfectant solution is prepared by the above method for a titration experiment. At the end point of the titration, the volume of the peracetic acid disinfectant solution consumed by the titration is about 0.4-2.5 mL. In a preferred embodiment, the peracetic acid disinfectant solution is prepared by the above method for a titration experiment. At the end point of the titration, the volume of the peracetic acid disinfectant solution consumed by the titration is about 0.4-2.0 mL.

In one embodiment, the glutaraldehyde disinfectant solution is prepared by the above method to perform a titration experiment. At the end point of the titration, the volume of the glutaraldehyde disinfectant solution consumed by the titration is about 3-5 mL. In a preferred embodiment, the glutaraldehyde disinfectant solution is prepared through the above method for a titration experiment. At the end point of the titration, the volume of peracetic acid disinfectant solution consumed by the titration is about 3.5-4.5 mL.

Stability of the composition of the invention

The stability of the composition of the present invention is tested by the following method.

(1) Prepare disinfectant aqueous solution;

(2) Prepare an aqueous solution of the composition of the present invention;

(3) Use the disinfectant aqueous solution of step (1) to titrate the composition aqueous solution of step (2), and record the volume C ₀ of the disinfectant aqueous solution consumed at the end point of the titration;

(4) Store the aqueous composition solution of step (1) in a closed space at a constant temperature for a period of time;

(5) Use the disinfectant aqueous solution of step (1) to titrate the composition aqueous solution of step (4), and record the volume C of the disinfectant aqueous solution consumed at the end point of the titration;

(6) Use first-order reaction kinetics to estimate the chemical kinetic parameters of the active substance and further obtain the half-life of the compound.

lg C＝-(kt/2.303)+lgC ₀

t _1/2 =0.693/k

Among them, k represents the rate constant (d ^-1 ), C ₀ represents the initial concentration, C represents the concentration at t, t-time is days (d), and t _1/2 represents the half-life.

In a specific embodiment, the stability of the composition of the invention is tested by the following method:

(1) Prepare disinfectant solution with a concentration of 1000ppm (1000mg/L);

(2) Prepare an aqueous composition solution of the present invention, wherein the content of the active ingredient (enol structure-containing compound and/or thiol structure-containing compound and/or amino acid) in the composition aqueous solution is about 2-3% by weight;

(3) Use the disinfectant solution obtained in step (1) to titrate 1 mL of the aqueous composition solution of step (2), and record the volume C ₀ of the disinfectant solution consumed at the end point of the titration;

(4) Store the aqueous composition solution of step (2) in a room temperature space (such as an indoor room with a north-facing window, no direct sunlight, but with natural light and fluorescent indoor lighting) for about 60-365 days.

(5) Use the disinfectant solution obtained in step (1) to titrate 1 mL of the aqueous composition solution of step (4), and record the volume C of the disinfectant solution consumed at the end point of the titration;

In one embodiment, an aqueous solution of trichloroisocyanuric acid is prepared by the above method and subjected to a titration experiment. After calculation, the half-life of the composition of the present invention is approximately 360-3600 days. In a preferred embodiment, an aqueous solution of trichloroisocyanuric acid is prepared by the above method and subjected to a titration experiment. After calculation, the half-life of the composition of the present invention is approximately 361-3300 days. For example, 365 days, 443 days, 443 days, 682 days, 1000 days, 2000 days, 3000 days, 3253 days.

Disinfection effect of the composition of the present invention and its compatibility with alcohol-based disinfectants

The compositions of the present invention are used to adsorb and neutralize irritating gases. Currently, WHO recommends disinfectants containing ethanol or isopropyl alcohol as the main ingredient (i.e., alcohol-based disinfectants) for skin disinfection. In order to confirm that the composition of the present invention will not affect the performance of alcohol-based disinfectants (that is, to confirm that masks using the composition of the present invention will not affect the disinfection effect of alcohol-based disinfectants on the skin), at the same time, in order to determine the Regarding the disinfection effect of the composition, the present invention designs relevant tests to test the compatibility of the composition with alcohol-based disinfectants.

The disinfection effect of the composition of the present invention and its compatibility with alcohol-based disinfectants were tested by the following method.

(1) Take a 50mL Erlenmeyer flask or a 15mL test tube;

(2) Add water and/or sterilizing alcohol and/or propylene glycol and/or composition 1 (water-glycerin solvent, without protein coagulant and plant extract) and/or composition to the container in step (1). 2 (water-propylene glycol solvent, containing protein coagulant and plant extracts);

(3) Add egg white to the mixture in step (3);

(4) Shake the container in step (3) for 5 minutes, and then observe the protein denaturation and precipitation effect.

In one embodiment, the pH of Composition 1 as well as Composition 2 is about 5.5-6.2.

In one embodiment, when composition 2 or the combination of composition 2 and disinfecting alcohol is added in step (2), the effect of protein denaturation and precipitation can be observed.

The ability and stability of the mask of the present invention to adsorb and neutralize irritating gases in oxidizing disinfectant solution

The ability of the mask of the present invention to neutralize irritating gases in oxidizing disinfectant solution

The ability of the mask of the present invention to neutralize irritating gases in the oxidative disinfectant solution is tested through the following two methods, namely qualitative testing and quantitative testing.

Qualitative testing

Method B

(1) Provide the mask of the present invention;

(2) Prepare disinfectant aqueous solution;

(3) Place the disinfectant aqueous solution of step (2) in a closed container, and shake the container to fill the container with volatile irritating gas;

(4) Open the sealed container in step (3), and the tester smells the gas in the container;

(5) Open the sealed container in step (3), and the tester smells the gas in the container before and after wearing the mask of the present invention.

Method C

(1) Provide the mask of the present invention;

(2) Paste test strips on the inner and outer surfaces of the central area of the mask;

(3) Prepare disinfectant aqueous solution;

(4) Heat the disinfectant solution and cover the mask on top of the disinfectant solution;

(5) Observe whether the volatile gases in the disinfectant penetrate the mask.

In one embodiment, the disinfectant aqueous solution configured in step (2) of method B and step (3) of method C is selected from the group consisting of chlorine-containing disinfectant aqueous solution, hydrogen peroxide wash solution, peracetic acid disinfectant solution, and chlorine dioxide disinfection and glutaraldehyde disinfectant. In a further embodiment, the chlorine-containing disinfectant aqueous solution is selected from the group consisting of trichloroisonitrile uric acid disinfectant solution and sodium hypochlorite disinfectant solution.

In one embodiment, the concentration of the disinfectant aqueous solution configured in step (2) of method B and step (3) of method C is selected from the group consisting of 1000ppm, 30000ppm, 5000ppm, 100ppm and 20000ppm.

In a specific embodiment, the disinfectant aqueous solution configured in step (2) of method B and step (3) of method C includes 1000 ppm chlorine-containing disinfectant solution, 30000 ppm hydrogen peroxide wash solution, 5000 ppm peracetic acid disinfectant solution, 100ppm chlorine dioxide disinfectant and 20000ppm glutaraldehyde disinfectant.

In one embodiment, the closed container used in Method B is a 100 ml iodine flask.

In one embodiment, in step (3) of method B, the amount of disinfectant used is about 5-10 mL. For example, about 5 mL, about 6 mL, about 7 mL, about 8 mL, about 9 mL, and about 10 mL.

In one embodiment, the test paper used in Method C is selected from the group consisting of chlorine test paper, chlorine dioxide test paper and glutaraldehyde test paper. In a specific embodiment, for chlorine-containing disinfectant and hydrogen peroxide disinfectant, the test paper used in method B is chlorine test paper; for chlorine dioxide disinfectant, the test paper used in method C is chlorine dioxide test paper; For glutaraldehyde disinfectant, the test paper used in method C is glutaraldehyde test paper.

In one embodiment, in step (2) of method C, the distance between the two pieces of detection test paper is 3-5 mm to facilitate the passage of airflow.

In one embodiment, according to the detection method of method B, before wearing the mask of the present invention, the tester can smell a strong irritating smell in the closed container; after wearing the mask of the present invention, the tester can smell the smell in about 2- No pungent odor can be smelled in the closed container within 5 minutes.

In a preferred embodiment, when using chlorine dioxide disinfectant and glutaraldehyde disinfectant for qualitative testing, the detection is only carried out by method C.

In one embodiment, according to the detection method of Method C, it is observed that the test paper changes color on the outside of the mask of the present invention, but does not change color on the inside of the mask of the present invention.

Quantitative testing

The ability of the mask of the present invention to neutralize irritating gases in the oxidative disinfectant solution is quantitatively tested by the following method D:

Method D

(1) Provide the mask of the present invention;

(2) Dissolve the mask in step (1) in water to obtain a mask extract;

(3) Prepare disinfectant aqueous solution;

(4) Use the disinfectant aqueous solution from step (3) to titrate the mask extract from step (2), and record the disinfectant aqueous solution consumed at the end point of the titration.

In a specific embodiment, the ability of the mask of the present invention to neutralize irritating gases in the oxidative disinfectant solution is quantitatively tested by the following method D1:

(1) Prepare the mask of the present invention according to the method of the present invention;

(2) Dissolve the mask in step (1) in 100 mL of water to obtain the mask extract;

(3) Prepare disinfectant aqueous solutions of different concentrations according to the above method A;

(4) Take 10 mL of the mask extract from step (2), titrate the mask extract with the disinfectant aqueous solution from step (3), and record the disinfectant aqueous solution consumed at the end point of the titration;

(5) Amplify the titration result of step (4) 10 times to obtain the mask's ability to neutralize irritating gases in the oxidizing disinfectant solution.

In one embodiment, the titration indicator is selected as described in Method A.

In one embodiment, the mask of the present invention may contain liquid in an amount of about 3-4 mL. For example, about 3 mL, about 3.2 mL, about 3.4 mL, about 3.6 mL, about 3.8 mL, about 4 mL.

In one embodiment, the mask extract of the present invention is titrated by the above method. At the end point of the titration, the volume of the trichloroisocyanuric acid aqueous solution consumed is about 90-100 mL.

In one embodiment, the mask extract of the present invention is titrated by the above method, and at the end point of the titration, the volume of hydrogen peroxide wash solution consumed is about 1-2 mL.

In one embodiment, the mask extract of the present invention is titrated by the above method, and at the end point of the titration, the volume of peracetic acid disinfectant consumed is about 8-10 mL.

In one embodiment, the mask extract of the present invention is titrated by the above method. At the end point of the titration, the volume of the consumed chlorine dioxide disinfectant aqueous solution is about 350-450 mL.

In one embodiment, the mask extract of the present invention is titrated by the above method, and at the end point of the titration, the volume of glutaraldehyde disinfectant solution consumed is about 10-15 mL.

Stability of the mask of the present invention

The stability of the mask of the present invention is tested through the following three methods, including qualitative testing, quantitative testing and microbial content determination.

Qualitative testing

The stability of the mask of the present invention was qualitatively tested by the following methods E and F.

Method E

(1) Provide the mask of the present invention;

(2) Place the mask in step (1) in an environment with a relative humidity of 70-95% and a temperature of 25-35°C for 14 days;

(3) The tester wears the mask obtained in step (3) for 30 minutes;

(4) Test the stability of the mask of the present invention according to method B.

Method F

(1) Provide the mask of the present invention;

(3) The tester wears the mask obtained in step (3) for 30 minutes;

(4) Test the stability of the mask of the present invention according to method C.

In one embodiment, the disinfectant solution, the concentration of the disinfectant solution, and the amount of the disinfectant solution used in Methods E and F are as described above.

In one embodiment, according to the detection method of method E, before wearing the mask of the present invention, the tester can smell a strong pungent odor in the closed container; after wearing the mask of the present invention, the tester can smell a weak smell The smell of disinfectant is non-irritating.

In one embodiment, according to the detection method of Method F, it is observed that the test paper changes color on the outside of the mask of the present invention, but does not change color on the inside of the mask of the present invention.

Quantitative testing

The stability of the mask of the present invention is tested by the following method G.

Method G

(1) Provide the mask of the present invention;

(3) Test the stability of the mask of the present invention according to method D.

In one embodiment, the mask extract of the present invention is titrated by the above method. At the end point of the titration, the volume of the trichloroisocyanuric acid aqueous solution consumed is about 30-40 mL.

In one embodiment, the mask extract of the present invention is titrated by the above method, and at the end point of the titration, the volume of hydrogen peroxide wash solution consumed is about 0.3-0.4 mL.

In one embodiment, the mask extract of the present invention is titrated by the above method. At the end point of the titration, the volume of peracetic acid disinfectant consumed is about 3-4 mL.

In one embodiment, the mask extract of the present invention is titrated by the above method. At the end point of the titration, the volume of the consumed chlorine dioxide disinfectant aqueous solution is about 170-180 mL.

In one embodiment, the mask extract of the present invention is titrated by the above method. At the end point of the titration, the volume of glutaraldehyde disinfectant solution consumed is about 10-12 mL.

Microbial content determination

The stability of the mask of the present invention was tested with reference to the detection method of "YY/T0969-2013 Disposable Medical Masks".

In a specific embodiment, the stability of the mask of the present invention is tested by the following method H.

Method H

(1) Provide the mask of the present invention;

(2) Obtain the mask extraction solution of step (1);

(3) Detect the number of bacterial colonies in the mask culture solution;

(4) Place the mask culture solution in an environment with a relative humidity of 70-95% and a temperature of 25-35°C for 14 days;

(5) Detect the number of bacteria in the mask culture fluid.

In one embodiment, the detected flora species include bacteria, fungi, and the like. Exemplary bacteria can be, for example, coliforms, Pseudomonas aeruginosa, Staphylococcus aureus, hemolytic Streptococcus, etc.

In one embodiment, the mask extract of the present invention is detected by the above method. After 14 days, the number of coliform bacteria is 0.

In another embodiment, the mask extract of the present invention is detected by the above method. After 14 days, the number of Pseudomonas aeruginosa bacterial colonies is 0.

In another embodiment, the mask extract of the present invention is detected by the above method. After 14 days, the number of Staphylococcus aureus colonies is 0.

In another embodiment, the mask extract of the present invention is detected by the above method. After 14 days, the number of hemolytic streptococci is 0.

In another embodiment, the mask extract of the present invention is detected by the above method. After 14 days, the number of fungal colonies is 0.

In one embodiment, the mask extract of the present invention is tested by the above method. After 14 days, the total number of bacterial colonies is 250 CFU/g, wherein the bacteria are non-pathogenic Paenibacillus urinae.

Color rendering ability of the mask of the present invention

The color development ability of the mask of the present invention is tested by the following method I.

Method I

(1) Provide the mask of the present invention;

(2) Prepare disinfectant aqueous solution;

(3) Heat the disinfectant solution and cover the mask on top of the disinfectant solution;

(4) Observe the color change of the mask.

In one embodiment, the above-mentioned method I is used to simulate the scenario of the mask of the present invention after repeated use.

In one embodiment, the method of heating the mask in Method 1 is fumigation, and the fumigation temperature is about 40-94°C.

In one embodiment, the method of heating the mask in Method 1 is fumigation, and the fumigation time is about 2-6 hours. In a preferred embodiment, after heating and fumigation, it is continued to be placed in a residual heat environment for about 16-18 hours.

In a specific embodiment, the type and concentration of the disinfectant solution are as described in methods B and C above.

In one embodiment, according to the detection method of Method I, the mask of the present invention will turn red after passing through the gas environment of high-concentration chlorine-containing disinfectant (such as hypochlorous acid disinfectant, chlorine dioxide disinfectant).

In one embodiment, according to the detection method of Method I, the mask of the present invention will turn into deep yellow after passing through the gas environment of high-concentration peroxide disinfectant.

In one embodiment, according to the detection method of Method I, after passing through the gas environment of high-concentration glutaraldehyde disinfectant solution, the mask of the present invention will turn into dark brown.

In another embodiment, before heating in step (3) of method 1, the following steps are also included:

(2.5) Paste the test paper on the inner surface of the mask.

In a preferred embodiment, the detection test paper is selected as described in method C above.

In a preferred embodiment, according to the detection method of Method I, after passing through the gas environment of high-concentration trichloroisocyanuric acid disinfectant solution, the test paper on the inside of the mask of the present invention does not change color.

In another preferred embodiment, according to the detection method of Method I, after passing through the gas environment of high-concentration hydrogen peroxide washing solution, the test paper on the inside of the mask of the present invention slightly changes color.

In yet another preferred embodiment, according to the detection method of Method I, after passing through the gas environment of high-concentration peracetic acid disinfectant solution, the test paper on the inner side of the mask of the present invention partially changes color.

In yet another embodiment, according to the detection method of Method I, after passing through the gas environment of high-concentration chlorine dioxide disinfectant, the test paper on the inside of the mask of the present invention does not change color.

In another preferred embodiment, according to the detection method of Method I, after passing through the gas environment of high-concentration glutaraldehyde disinfectant solution, the test paper on the inside of the mask of the present invention does not change color.

The heat dissipation ability of the mask of the present invention

The heat dissipation ability of the mask of the present invention is tested by the following method J.

Method J

(1) Provide the mask of the present invention;

(2) The tester wears the mask in step (1) for 45 minutes;

(3) The tester wears a mask and takes a thermal image temperature measurement;

(4) The tester takes off the mask and takes a thermal image temperature measurement.

In one embodiment, according to the detection method of Method J, the temperature of the area of the mask of the present invention that contacts the skin is about 2-3°C lower than the area below the nostrils that does not contact the skin. For example, about 2°C, about 2.2°C, about 2.4°C, about 2.6°C, about 2.8°C, and about 3°C.

beneficial effects

The composition of the present invention uses a biosorbent and a hygroscopic agent. Through the adsorption effect of the hygroscopic agent on water, the composition becomes a moist or solution state, thereby increasing the contact area between the active ingredient biosorbent and irritating gases. , effectively improve the efficiency of adsorbing and neutralizing irritating gases, and can effectively reduce the concentration of certain irritating gases in the air, such as chlorine, chlorine dioxide, hydrogen peroxide, peracetic acid and aldehyde compounds, etc. In addition, since the composition of the present invention can be changed into a moist or solution state, which increases the contact surface between the active ingredients and irritating gases, the composition of the present invention can absorb and neutralize it more effectively than vitamin C itself. Irritating gas.

In addition, the aqueous composition solution of the present invention can also effectively absorb and neutralize irritating gases, especially irritating gases in oxidative disinfectants. Compared with the aqueous solution of vitamin C, the aqueous solution of the composition of the present invention can significantly improve the absorption capacity of irritating gases.

Furthermore, the base material containing the composition of the present invention can also effectively absorb and neutralize the irritating odor gas generated by the volatilization of high-efficiency disinfectants in the air, and is suitable for disinfection workers such as hospital infection control and epidemic prevention. Especially in occupational exposure environments where harmful microorganisms and the volatile odor of high-efficiency disinfectants coexist, it provides protective effects on the respiratory tract, skin, and mucous membranes; it can also be used as an antagonist for those who accidentally ingest or misuse high-efficiency disinfectants, leading to disinfectant poisoning. The base material containing the composition of the present invention can also be used in many technical fields such as daily cleaning disinfection products and air freshening equipment (such as reducing the concentration of formaldehyde and glutaraldehyde in the environment), and may be used for microbial protection in certain specific fields. or play a role in air purification.

Furthermore, the multilayer material containing the composition of the present invention can adsorb and neutralize a variety of irritating gases, so it can be applied to different occasions and effectively adsorb and neutralize chlorine, hydrogen peroxide, peracetic acid, and aldehydes. Compounds and other gases.

In addition, masks containing the composition of the present invention may reduce the use of activated carbon masks in some specific fields, and the components in the composition are mostly edible or harmless substances to the human body. Moreover, masks containing the composition of the present invention may reduce the risk of activated carbon powder in traditional activated carbon masks being inhaled by the human body or polluting the working environment. This is because activated carbon requires high energy consumption in the production process, and old activated carbon that has adsorbed toxic and hazardous substances is considered hazardous solid waste by current regulations in some countries.

In addition, the active ingredients in the base material, multi-layer material or mask containing the composition of the present invention can be extracted by solvent to obtain an extract of the above-mentioned materials. Therefore, in an emergency, it is also possible to quickly extract the active ingredients from the material of the present invention. The extract of the active ingredient biosorbent can be used for on-site detoxification of those who accidentally ingested or misused the disinfectant through oral administration, skin and mucous membrane rinses, wet compresses, etc.

In addition, due to the use of a hygroscopic agent, the multi-layer material containing the composition of the present invention can achieve a hygroscopic agent-water concentration gradient balance between the center and edge positions of the multi-layer material, which is conducive to the volatilization of moisture and taking it away. heat, thereby lowering the temperature around the multilayer material. Specifically, for example, when wearing a mask containing the composition of the present invention, the wearer's facial temperature will be lower and the wearer will not feel stuffy. In particular, the facial skin temperature is lower than the skin temperature under the nostrils.

Furthermore, the composition of the present invention has the property of color development and indication, and the composition will change color after high-intensity use in the air. Therefore, when the composition of the present invention is used in products such as masks and multi-layer materials, it can provide timely feedback on the status of active ingredients and facilitate replacement of the composition.

Furthermore, the composition of the present invention has excellent stability. First of all, the composition of the present invention contains bioactive ingredients such as enol-containing compounds, sulfhydryl-containing compounds, and amino acids. Even if it is left standing in the air for a long time, the composition can still absorb and neutralize irritating gases in the air. , such as chlorine, chlorine dioxide, hydrogen peroxide, peracetic acid and aldehyde compounds, etc. In addition, adding plant extracts to the composition of the present invention can have a light-shielding effect and greatly increase the shelf life of the active ingredients, allowing them to absorb and neutralize irritating gases in the air after long-term storage. Compared with vitamin C itself, the composition of the present invention has better stability.

Furthermore, the compositions of the present invention do not affect the performance of disinfecting alcohols. Furthermore, the composition also contains protein coagulant and plant extract components. The corresponding composition may have the effect of inhibiting the activity of surface proteins of microorganisms such as viruses, bacteria, fungi, etc., and may enhance and prolong the activity of surface proteins of microorganisms such as viruses, bacteria, and fungi when used in conjunction with disinfectant alcohol. The disinfection effect of alcohol also reduces the irritation of disinfectant alcohol to the skin.

Example

The solution of the present invention will be described in further detail below with reference to specific embodiments.

It should be noted that the following examples are only examples to clearly illustrate the technical solutions of the present invention, and are not intended to limit the present invention. For those of ordinary skill in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to exhaustively enumerate all the implementation methods, and the obvious obvious consequences derived from this Changes or modifications are still within the protection scope of the invention. Unless otherwise specified, the instrumentation and reagent materials used in this article are commercially available.

instrument

Glass instruments: volumetric flask, graduated pipette, iodine flask, beaker, Erlenmeyer flask (Erlenmeyer flask), measuring cup, evaporating dish (ceramic, round bottom, 100ml), vacuum drying dish, glass rod (diameter about 2mm), Sichuan Shubo (Group) Co., Ltd.

Analytical balance: METTLER TOLEDO ME 204 electronic balance. MAX 220g:d＝0.1mg.

Acidometer: Mettler Toledo FiveEasy Plus FE28-S pH resolution 0.01

Electric constant temperature water bath: 1000W, ±0.5℃, Shanghai Yuejin Medical Equipment Co., Ltd.

Material

Oxidizing disinfectants:

Trichloroisocyanuric acid disinfectant tablets: Hangzhou Langso Medical Disinfectant Co., Ltd. Available chlorine content is 500±50mg/tablet.

Sodium hypochlorite disinfectant: Hangzhou Langso Medical Disinfectant Co., Ltd. Concentration 4.5-5.5% by weight.

Chlorine dioxide disinfectant tablets: Beijing Hualong Xingyu Technology Development Co., Ltd. Chlorine dioxide content is 100±10mg/tablet.

Hydrogen peroxide lotion: Shandong Ruitaiqi Washing and Disinfection Technology Co., Ltd. Concentration 2.5-3.5% by weight.

Peracetic acid disinfectant (binary packaging): Shandong Anjie Hi-Tech Disinfection Technology Co., Ltd. Concentration 15-18% by weight.

Glutaraldehyde disinfectant: Shanghai Likang Disinfection High-Tech Co., Ltd. Concentration 2.1-2.6% by weight.

Chlorine test paper: Hangzhou Langso Medical Disinfectant Co., Ltd. The concentration is 0-2000ppm.

Hydrogen peroxide test paper: Hangzhou Luheng Biotechnology Co., Ltd. The concentration is 0-25ppm.

Peracetic acid test paper: Hangzhou Luheng Biotechnology Co., Ltd. The concentration is 0-40ppm.

Glutaraldehyde test paper: Hangzhou Luheng Biotechnology Co., Ltd. The concentration is 0-3% by weight.

Chlorine dioxide test paper: Changsha Shangqing Environmental Protection Technology Co., Ltd. The concentration is 0-20ppm.

Dilute hydrochloric acid: Sinopharm Chemical Reagent Co., Ltd. Analytically pure, diluted to 10% by weight.

Formaldehyde solution: Sinopharm Chemical Reagent Co., Ltd. Analytically pure (contains methanol inhibitor). Content 37-40% by weight.

Sodium hydroxide standard titration solution: National Standard Material GBW(E)081029, Shanghai Chemical Reagent Research Institute Co., Ltd., c(NaOH)=0.1030mol/L.

NaHCO ₃ (sodium bicarbonate): Tianjin Zhiyuan Chemical Reagent Co., Ltd. Analytically pure.

Vitamin C (ascorbic acid): purchased from Fuchen (Tianjin) Chemical Reagent Co., Ltd. Analytically pure.

Acetylcysteine injection (4g: 20ml): for content analysis, Hangzhou Minsheng Pharmaceutical Co., Ltd., national drug approval number H20051788.

N-acetylcysteine: for preparation, Henan Jimei Chemical Products Co., Ltd., food additive.

EDTA Na ₂ (disodium ethylenediaminetetraacetate): Shanghai Chemical Reagent Co., Ltd. Analytically pure.

Sodium metabisulfite: Hunan Erkang Pharmaceutical Co., Ltd. medical supplements.

Sodium hydroxide: Nanjing Chemical Reagent Co., Ltd. Analytically pure.

Glycerin: Hunan Erkang Pharmaceutical Co., Ltd. medical supplements.

Propylene glycol (1,2 propylene glycol): Hunan Erkang Pharmaceutical Co., Ltd. medical supplements.

Sodium hydrogen phosphate-disodium hydrogen phosphate buffer: Nanjing Chemical Reagent Co., Ltd. Analytically pure, self-prepared.

Ethylparaben: Hunan Erkang Pharmaceutical Co., Ltd. medical supplements.

Activated carbon layer fabric (carbon sandwiched non-woven fabric): Kunshan Green Chuang Electronic Technology Co., Ltd.

Polyester filter cotton: primary air filter cotton, thickness 0.3-1mm.

Catalase: Henan Yangshao Biochemical Engineering Co., Ltd. food ingredients.

Glycine: Sinopharm Chemical Reagent Co., Ltd. Analytically pure.

L-Alanine: Henan Jiazhi Chemical Products Co., Ltd. Food grade additives.

L-serine: Henan Jiazhi Chemical Products Co., Ltd. Food grade additives.

Polysorbate-80 (Tween 80): Taicang Pharmaceutical Factory. medical supplements.

Triethanolamine: Sinopharm Chemical Reagent Co., Ltd. Analytically pure.

(Light) liquid paraffin: Hunan Erkang Pharmaceutical Co., Ltd. medical supplements.

Disinfection alcohol: Prepare your own with absolute ethanol and water, or use commercially available finished products directly, with an ethanol content of 70-75% (V/V). Changshu Yangyuan Chemical Co., Ltd. Analytically pure.

Egg white: The egg white part of commercially available raw eggs is rich in a variety of proteins, with the main component being ovalbumin.

Cotton masks:

The weight is about 9.8g/piece, double-layer pure cotton knitted fabric. It is a washable and reusable daily knitted mask mainly used for decoration, cleaning, and warmth. The estimated cotton thread specification is 40S, and the density of each layer of fabric is about 200g/ ^m2 . , filter layer area is about 105.2cm ² , neutral packaging, selling price is about 0.63RMB/piece.

Disposable non-woven masks: robust

Medical nursing masks. ROBUST MEDICAL LIMITED. The price is about 0.8RMB/piece.

Glucono-delta-lactone: Anhui Xingzhou Pharmaceutical Food Co., Ltd., food additive.

Grape seed extract (proanthocyanidins): Xi'an Rongzhen Biotechnology Co., Ltd., proanthocyanidin content 95% OPC (UV), [CAS No]: 84929-27-1.

Edible green apple flavor, pineapple flavor: Henan Tongya Biotechnology Co., Ltd.

Lemon oil: Guangzhou Huixin Biotechnology Co., Ltd., [CAS No]: 8008-56-8, the main component is limonene.

3M ^TM 8246 Occupational Protective Mask: R95 activated carbon anti-particle mask, used for acid gas and oily/non-oily particle protection, Minnesota Mining and Manufacturing. The retail price is about 28RMB/piece.

3M ^TM 8247 Occupational Protective Mask: R95 activated carbon anti-particle mask, used for organic vapor odor and oily/non-oily particle protection, Minnesota Mining and Manufacturing. Retail price is about 28RMB/piece.

Example 1 Preparation of aqueous composition solution

Composition A aqueous solution

Add 27g vitamin C, 13g sodium bicarbonate, 0.027g EDTA Na ₂ and 1.80g sodium metabisulfite to 1000mL purified water to adjust to volume, stir the above solution to evenly mix the above components, and obtain a concentration of 2.7% (W/V) of vitamin C solution.

Composition B aqueous solution

Add 2.4g N-acetylcysteine, 0.4g sodium hydroxide, and 0.06g EDTA Na ₂ to 100 mL purified water to adjust to volume, stir the above solution, and mix the above components evenly to obtain a concentration of 2.4% (W/ V) N-acetylcysteine solution.

Composition C aqueous solution

Add 6 g of glycine to 100 mL of purified water to make it up to volume, stir the above solution, and mix the above components evenly to obtain a glycine solution with a concentration of 6% (W/V).

Composition D aqueous solution

Add 6g glycine, 4.5g L-alanine and 4.5g L-serine to 100mL purified water to adjust to volume, stir the above solution to evenly mix the above components to obtain a complex amino acid solution.

Example 2 Preparation of the mask of the present invention

Mask A

Mix 4.5 mL of composition A aqueous solution, 1.5 mL of composition B aqueous solution, 128 mg of glycine and 1.6 g of glycerin, and then add sodium dihydrogen phosphate-disodium hydrogen phosphate buffer (pH=6.0) and 6 mg of glycerin to the solution. Ethyl hydroxyphenyl ester and stir evenly. After the above solution is evenly infiltrated into the base material of the mask, it is dried in a nitrogen atmosphere to obtain mask A.

As shown in Figure 1, 102 represents the ear strap of the mask, and 101 represents the base material of the mask, which has the above composition adsorbed thereon.

Mask B

Mix 12 mL of composition A aqueous solution, 6 mL of composition B aqueous solution and 1.75 g of glycerin, and then add sodium dihydrogen phosphate-disodium hydrogen phosphate buffer (pH=6.0) and 6 mg of ethyl hydroxyphenyl ester to the solution. Stir evenly. After the above solution is uniformly infiltrated into the base material of the mask, it is dried in a nitrogen atmosphere to obtain the base material 101 of mask B. Then, the activated carbon layer 201 is fixed on the outside of the base material 101 by hot melting to obtain the mask B.

As shown in Figure 2, 102 represents the ear strap of the mask, 101 represents the base material of the mask, and 201 represents the activated carbon layer of the mask. In addition, according to the needs of the working environment, in scenes where fine particles (such as dust, pollen, etc.) need to be filtered, a melt-blown cloth filter layer can also be inserted between the activated carbon layer 201 and the base material 101 to block fine particles. Since peracetic acid is an organic vapor, adding an activated carbon layer to mask B can effectively strengthen the physical adsorption of the mask, thereby achieving a combined filtration effect of physical adsorption and chemical adsorption neutralization.

Mask C

Mix 15 mL of composition A aqueous solution, 3 mL of composition B aqueous solution and 1.75 g of glycerin, and then add sodium dihydrogen phosphate-disodium hydrogen phosphate buffer (pH=6.0) and 6 mg of ethyl hydroxyphenyl ester to the solution. Stir evenly. After the above solution is evenly infiltrated into the base material of the mask, it is dried in a nitrogen atmosphere to obtain the first base material 101 of the mask C. Mix catalase, 1.75 g of glycerin, 6 mg of ethyl hydroxyphenyl ester and sodium dihydrogen phosphate-disodium hydrogen phosphate buffer (pH=7.4) and stir evenly. After the above solution is evenly infiltrated into the base material of the mask, it is dried in a nitrogen atmosphere to obtain the second base material 301 of the mask C. Polyester filter cotton with a thickness of 3 mm is used as the middle isolation layer 302. Arrange the first base material 101, the middle isolation layer 201 and the second base material 301 in order from the outside to the inside, and prepare a multi-layer mask C by hot melting.

As shown in Figure 3, 102 represents the ear strap of the mask, 101 represents the first base material of the mask, 302 represents the second base material, and 301 represents the second base material. Since the active substances in the first base material 101 and the second base material 302 need to work in different pH environments, the active substances in the first base material 101 are relatively stable in a weakly acidic environment of pH 5.0-6.2, while peroxidation Hydrogenase can maximize the catalytic decomposition of hydrogen peroxide in a pH 7.0 environment. Therefore, the middle isolation layer 302 can effectively isolate the active substances of the two base materials, and the use of polyester filter cotton will not affect the air circulation. . In addition, arranging the second base material 301 on the inside close to the person's face can make the second base material 301 have a relatively high temperature, which is more conducive to the decomposition of hydrogen peroxide by catalase.

Mask D

Combine 2.7g vitamin C, 9.6g glycerin, 0.0375g ethyl hydroxyphenyl ester, 0.0006g EDTA-Na ₂ , 0.005g sodium metabisulfite, 0.5625g N-acetylcysteine, 1.8g glycine, 1.35g L-alanine , 1.35g L-serine and 1.3g sodium bicarbonate were added to 25mL pure water to adjust to volume. Place the above composition solution into a spray bottle, and add 0.6 ml of liquid paraffin as a liquid sealing layer. Provide a cotton mask, and spray the above composition solution evenly on the inside and outside of the mask to obtain mask D.

The spraying process of mask D is shown in Figure 9.

Mask E

Combine 210g propylene glycol, 0.6g glucono-delta-lactone, 0.03g EDTA-Na ₂ , 0.1g sodium metabisulfite, 36g glycine, 36g alanine, 18g serine, 54g vitamin C, 13g N-acetylcysteine, 30g sodium bicarbonate, 3.5g grape seed extract (proanthocyanidins), 1.2g lemon oil, 0.6g ethyl hydroxyphenyl ester, and 200g water are prepared into a 500ml composition liquid. The above composition solution was dispensed into 20 ml spray bottles, and 0.6 ml of liquid paraffin was added to each bottle as a liquid sealing layer. Provide a cotton mask, and spray the above composition solution evenly on the inside and outside of the mask according to the method shown in Figure 9 to obtain Mask E.

Example 3 Neutralizing abilities of vitamin C, N-acetylcysteine and glycine against high-efficiency disinfectants

Dissolve 2.7g of vitamin C in 100 mL of purified water to prepare a vitamin C solution with a concentration of 2.7% (W/V).

Dissolve 2.4g N-acetylcysteine in 100mL purified water to prepare an N-acetylcysteine solution with a concentration of 2.4% (W/V).

Dissolve 6.0 g of glycine in 100 mL of purified water to prepare a glycine solution with a concentration of 6% (W/V).

According to Table 1, prepare an aqueous disinfectant solution, and use the disinfectant to titrate 1 mL of vitamin C solution, N-acetylcysteine, and glycine. Use a titration indicator to determine the titration end point. If necessary, use an auxiliary indicator to develop color to help determine the titration end point. At the end point of the titration, the disinfectant solution consumed is recorded.

Table 1

a. The measured pH of 1000ppm sodium hypochlorite disinfectant is 11.32, which is highly alkaline. However, the color sensitivity of chlorine test paper decreases in an alkaline environment. Therefore, traditional hypochlorous acid-based chlorine-containing disinfectants must be titrated under the acidic conditions of dilute hydrochloric acid. Only neutralizer can be added to dilute hydrochloric acid, and chlorine-containing disinfectant cannot be added to avoid reversal of the equation of Cl ₂ +H ₂ O → HCl + HClO.

b. The measured pH of 5000ppm peracetic acid disinfectant is 2.1, which is highly acidic and exceeds the color development conditions of peroxide test paper. It needs to be neutralized by acid and alkali before using test paper to detect the peroxide concentration. The neutralization product of peracetic acid and acetylcysteine can cause the peroxide detection test paper to fade, and the maximum value of the color change at the moment when the test paper is put into the solution is taken as the reading.

c. Peroxide disinfectants are more oxidizing than chlorine-containing disinfectants and can cause the chlorine test paper to turn brown and then further oxidize, causing the brown product to fade. Therefore, the chlorine test paper cannot be directly put into the reaction system.

d. The reaction between glycine and glutaraldehyde can be carried out at room temperature. The reaction condition is pH>5.0. A yellow product is usually generated within 5-10 seconds and gradually becomes darker. However, the detection range of currently commercialized glutaraldehyde test paper is 0 -3%, most are also glycine colorimetric methods. Since the color reaction of the test paper is also yellow-orange, the test paper reading is easily disturbed. Currently, there are no high-sensitivity test strips with a measurement range of less than 100 ppm.

e. Heat glutaraldehyde and excess glycine to fully react, then use an acidometer, sodium hydroxide standard titration solution and formaldehyde solution to measure the changes in amino acid content in the sample to deduce the glycine consumed by glutaraldehyde. For details, see Implementation Example 9.

f. The α-amino group of amino acids combines with hypochlorous acid to form chloramine. Its reaction rate constant K ₂ is 1.0×10 ⁵ M ^-1 s ^-1 , which is much lower than the cysteine side chain K ₂ of 3.0×10 The reaction rate constant is ⁷ M ^-1 s ^-1 , so this slow neutralization effect cannot be observed in titration experiments.

As shown in Table 1, aqueous solutions of vitamin C and N-acetylcysteine can effectively neutralize hypochlorous acid in chlorine-containing disinfectants, while aqueous solutions of glycine can effectively neutralize glutaraldehyde-containing disinfectants. agent. In the composition of the present invention, the moisture absorbing agent has the function of absorbing water and can change the composition into a moist state or a solution state, that is, corresponding to the vitamin C aqueous solution, N-acetylcysteine aqueous solution and Glycine aqueous solution, while the moisture attractant will not participate in the reaction between the above compounds and chlorine, and will not affect the efficiency of the neutralization reaction. Therefore, the above results confirm that the compounds of the present invention can effectively adsorb and neutralize chlorine-containing disinfectants, peroxide-containing disinfectants and glutaraldehyde-containing disinfectants, and can adsorb and neutralize the irritating gases volatilized by the above-mentioned disinfectants. .

Example 4 Qualitative test of the mask's ability to adsorb and neutralize irritating gases in disinfectants

(1) Prepare the disinfectant according to the medical disinfection concentration in Table 1, transfer 5 mL of disinfectant into a 100 mL iodine bottle through a pipette, seal the bottle tightly, and shake vigorously for about 1 minute to remove the volatile irritation from the disinfectant. Sexual gas fills the sealed iodine bottle. Before and after wearing the mask A of the present invention, the tester opens the bottle stopper, smells the smell close to the mouth of the bottle for 2-5 minutes, and records the color development of the test paper.

Among them, due to the strong volatility and irritation of chlorine dioxide disinfectant and the sensitization of glutaraldehyde disinfectant, it is recommended not to conduct the above-mentioned (()) on the two disinfectants due to experimental safety and ethical considerations. 1) A qualitative experiment.

(II) Prepare the disinfectant according to the medical disinfection concentration in Table 1, transfer 5 mL of disinfectant into a 100 mL iodine bottle through a pipette, and slightly add iodine to the bottle to evaporate the disinfectant. The mask A of the invention is placed in the central area of the above-mentioned iodine bottle. The front and back sides of the central area of the mask are respectively pasted with test paper with a length of about 10mm. The two test papers are 3-5mm apart to facilitate the passage of airflow. For chlorine-containing disinfectants (such as trichloroisocyanuric acid disinfectant, sodium hypochlorite disinfectant), hydrogen peroxide and peracetic acid disinfectants, the test paper used is chlorine test paper; for chlorine dioxide disinfectant, the test paper used is chlorine test paper Chlorine oxide test paper; for glutaraldehyde disinfectant, the test paper used is glutaraldehyde test paper. After heating the iodine bottle for 2-5 minutes, you can observe that the test paper on the outside of the mask changes color, but the test paper on the inside of the mask does not change color.

Through the above qualitative experiments, it can be confirmed that the mask of the present invention can effectively absorb and neutralize irritating gases in various disinfectants.

In addition, mask A is adsorbed with the composition of the present invention, which contains bioactive ingredients such as vitamin C, N-acetylcysteine, glycine, etc. Therefore, the above qualitative experiment can also confirm that it is effective against irritating gases (such as those in disinfectant solutions). irritating gases), the composition of the present invention has excellent absorption capacity. In addition, the composition of the present invention can absorb and neutralize irritating gases more effectively than vitamin C itself.

Example 5 Quantitative test of the mask’s ability to adsorb and neutralize irritating gases in disinfectants

Put the mask A of the present invention into a 250 ml conical flask, and add 100 mL of water to the conical flask. Stir the water in the above-mentioned Erlenmeyer flask to fully dissolve the components of mask A in the water to obtain the mask extract. Take out 10mL of mask extract and perform a titration experiment according to the method in Table 1 to determine the content of active substances in the mask. The measurement results are magnified 10 times to obtain the content of active substances in the mask. The test results are shown in Table 2.

Table 2 Test of active substance content in newly prepared masks

The above results can confirm that the mask of the present invention can effectively absorb and neutralize irritating gases in various disinfectants. In addition, mask A adsorbs the composition of the present invention, so the above results can also confirm that the composition of the present invention has excellent absorption capacity for irritating gases (such as irritating gases in disinfectant solutions). In addition, the composition of the present invention can absorb and neutralize irritating gases more effectively than vitamin C itself.

Example 6 Qualitative robustness test of masks

Place mask A in an environment with a relative humidity of 70-95% and a temperature of 25-35°C for 14 days. After 14 days, the tester first wore mask A for about 30 minutes to fully moisten mask A and reach a moisture balance state, and then tested the stability of mask A according to the method of Example 4.

The test results show:

According to the method (1) of Embodiment 4, the mask turns yellow within a few hours after being exposed to the air. After the tester wears the above mask A, the tester can smell a slightly faint disinfectant smell, but the smell is not irritating.

According to the method (2) of Example 4, after heating for 2-5 minutes, it can be observed that the test paper on the outside of the mask changes color, but the test paper on the inside of the mask does not change color.

The above results can confirm that even if it is oxidized and discolored by air, the mask of the present invention still has the ability to absorb disinfectants and neutralize irritating gases, and the mask of the present invention has excellent stability.

In addition, mask A is adsorbed with the composition of the present invention, which contains bioactive ingredients such as vitamin C, N-acetylcysteine, glycine, etc., each of which has different reducing properties or reactivity. Even if it is left standing in the air for a long time, For a long time (such as 14 days), the composition can still absorb and neutralize irritating gases (such as irritating gases in the air or in disinfectants). Therefore, the above results can also confirm that the composition of the present invention has excellent stability. sex. In particular, the combination of the invention has significantly improved stability compared to vitamin C itself.

Example 7 Mask Quantitative Robustness Test

Place mask A in an environment with a relative humidity of 70-95% and a temperature of 25-35°C for 14 days. After 14 days, mask A was oxidized by air and turned yellow, and then the stability of mask A was tested according to the method of Example 5. The test results are shown in Table 3.

Table 3 Contents of residual active substances in mask A that turned yellow and was oxidized by air

The above results can confirm that even if it is oxidized and discolored by air, the mask of the present invention still has the ability to absorb disinfectants and neutralize irritating gases, and the mask of the present invention has excellent stability. In addition, mask A adsorbed the composition of the present invention, so the above results can also confirm that the composition of the present invention has excellent stability. In particular, the combination of the invention has significantly improved stability compared to vitamin C itself.

Example 8 Determination of microbial content of masks

Referring to the testing method of "YY/T0969-2013 Disposable Medical Masks", among the microbial indicators, the microbial limits of non-sterile masks are: bacteria ≤100CFU/g, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, hemolysis Sexual streptococci and fungi shall not be detected. According to the above inspection method, mask A is unpacked in a class 100 ultra-clean bench, extracted with 0.9% sodium chloride injection, and the extract is added to agar culture medium.

In order to observe the use in the real world, mask A was placed in an environment with a relative humidity of 70-95% and a temperature of 25-35°C for two weeks, then soaked in water to dilute the preservative, and then sampled and operated in an open environment to observe The impact of environmental bacteria on masks. The test results are shown in Table 4.

Table 4 Microbial indicator test results of masks

Judging from the microbial index test results, due to the addition of the preservative (ethyl hydroxyphenyl ester), the microbial index of the mask not only meets the requirements of industry standards, but also inhibits environmental microorganisms. As detected by the Bruker Microbial Identification Mass Spectrometry Analysis System, the cultured environmental colony microorganisms are mainly Paenibacillus urinae, which can produce spores and is resistant to harsh environments (such as preservatives), so it grows in low-concentration preservative environments. , this bacterium is a non-pathogenic background microorganism, mostly coming from animal urine.

Example 9 Method for determination of reaction end point between glutaraldehyde and amino acids

In Table 1, the reaction end point of glycine (or other amino acids) neutralizing glutaraldehyde disinfectant is determined by the following method:

(1) Provide amino acid aqueous solution and glutaraldehyde disinfectant;

(2) Mix the amino acid and glutaraldehyde disinfectant in step (1) and dilute to volume;

(3) Heating the constant volume mixture in step (2) and further diluting the volume;

(4) Dilute the mixed solution in step (3) and measure the pH value of the mixed solution;

(5) Use sodium hydroxide aqueous solution to titrate the mixed solution in step (4) until the pH is 8.2;

(6) Add the formaldehyde solution to the mixed solution of step (5);

(7) Cool the mixed liquid in step (6) and measure the pH value of the mixed liquid;

(8) Use sodium hydroxide aqueous solution to titrate the mixed solution in step (7) to pH 9.2, and record the volume V ₁ (mL) of the titrant solution;

(9) Dilute the mixed solution of step (8), and titrate the mixed solution of step (8) using sodium hydroxide aqueous solution to a pH of 8.2;

(10) Add the formaldehyde solution to the mixed solution of step (9);

(11) Use sodium hydroxide aqueous solution to titrate the mixed solution in step (10) to pH 9.2, and record the volume V ₂ (mL) of the titrant;

(12) Obtain the concentration of amino acid substance C _{amino acid} (weight %) in 1ml of glutaraldehyde disinfectant according to the following formula (II):

C _{amino acid} = [(V ₁ -V ₂ ) × C _NaOH × 0.001 × MW _{amino acid} / (5 × 20/100)] * 100% (II)

in,

V ₁ represents the volume of sodium hydroxide standard titration solution consumed after formaldehyde is added to the sample diluent for measurement, in milliliters (mL);

V ₂ represents the volume of sodium hydroxide standard titration solution consumed after adding formaldehyde in the reagent blank test, in milliliters (mL);

C _NaOH represents the concentration of sodium hydroxide standard titration solution, in moles per liter (mol/L);

MW _{amino acid} represents the molar mass (molecular weight) of the amino acid, in grams per mole (g/mol);

In the present invention, 6 wt% glycine is used to react with 2 wt% glutaraldehyde disinfectant, and the reaction end point is determined by the above method. The specific experimental steps are:

(1) Use a pipette to accurately measure 10 ml of 6 wt% glycine aqueous solution and 1 ml of 2 wt% glutaraldehyde disinfectant. Add the above solution into a 25 ml volumetric flask and mix well. After sealing the volumetric flask, place it in a water bath at about 50°C and heat for 20 minutes. After the reaction is completed, cool the mixture to room temperature and measure 5 ml of the dark brown reaction solution. Add the above reaction solution into a 100 ml volumetric flask, add water, mix and dilute to constant volume.

(2) Measure 20ml of the above diluent, add it to a 250ml Erlenmeyer flask, add 60ml of water, and insert the acidimeter electrode to measure the pH value. Shake and adjust to pH 8.2 with a sodium hydroxide standard titration solution of about 0.05-0.1mol/L.

(3) Measure 10 ml of formaldehyde solution (analytically pure, content 35-40% by weight), and add it to the above-mentioned Erlenmeyer flask and shake well. Cover the mouth of the conical flask with a 50 ml beaker, and then place the conical flask in a water bath at about 50°C to heat for 10 minutes. After the reaction is completed, cool to room temperature and then insert the acidimeter electrode to measure the pH value. Continue the shaking titration with the above-mentioned sodium hydroxide standard titration solution to pH 9.2, and record the consumed titrant volume V ₁ (mL).

(4) Add 80ml of water into a 250ml Erlenmeyer flask, adjust to pH 8.2 with the above sodium hydroxide standard titration solution, then add 10ml of formaldehyde solution, and continue shaking and titrating with the above sodium hydroxide standard titration solution to pH 9.2. Note down the consumed titrant volume V ₂ (mL). Pay attention to ventilation during operation to avoid inhaling too much formaldehyde vapor.

Calculate according to the above formula (II) to obtain the concentration of amino acid substance C _{amino acid} (weight %) in 1 ml of glutaraldehyde disinfectant solution.

Among them, the amino acid used in the embodiment of the present invention is glycine, and its molar molecular weight is 75.07g/mol.

Table 5 shows the end-point test results of the reaction between glutaraldehyde disinfectant and glycine.

Table 5 Test results of the reaction ratio between glutaraldehyde disinfectant and glycine

It can be seen from the above specific examples that after titrating the 6% glycine solution, the calculated concentration result is 5.884%, and the titration analysis recovery rate is 98.07%, which meets the analysis requirements of the national standard. The volume of 1ml of 2% glutaraldehyde disinfectant and 10ml of 6% glycine is still 11ml. Therefore, the stoichiometric point of the reaction between 2% glutaraldehyde disinfectant and glycine can be expressed as:

1ml of 2 wt% glutaraldehyde disinfectant consumes 10×5.884%-11×5.212%=0.01508g of glycine.

The analysis method of the present invention can accurately obtain the stoichiometric point of the material consumption ratio of the neutralization reaction between glutaraldehyde and amino acid substances, that is, accurately obtain the end point of the neutralization reaction and obtain the amount of consumed amino acids.

Example 10 Experiment on the protective ultimate performance and color rendering performance of the mask of the present invention

In order to further confirm the practicability of the mask of the present invention, the protective limit performance and color rendering performance of the mask of the present invention were tested by the following methods.

(I) Mask protective limit performance testing experiment

The steps of the mask protective limit performance detection test are similar to the method (II) of Example 4, with the difference being:

(i) Heating the mask through fumigation to simulate the situation after the mask is reused multiple times;

(ii) In a specific embodiment, after the mask is fumigated, it is placed in the residual heat environment after fumigation for a period of time;

(iii) After the mask is fumigated, a titration experiment is performed according to the method of Example 1.

(II) Color rendering performance experiment of masks

The color rendering performance of the mask is similar to the mask protective limit performance experiment. The difference is:

After the mask is fumigated, observe the color change of the mask to obtain the content of the active ingredients in the mask.

In order to confirm the protective ultimate performance and color rendering performance of the mask of the present invention, 3M ^TM occupational exposure protective mask was used as a comparative example.

Glutaraldehyde disinfectant protective limit performance test

Paste a piece of glutaraldehyde test paper on the inner surface of mask D, and wrap the test paper with waterproof and breathable material (such as the blue waterproof layer of a medical mask) to prevent it from being contaminated by the active ingredients of mask D. Set the water bath to about 95°C and place a 100ml evaporating dish on the water bath to fully preheat. Use a pipette to measure 25 ml of 2 wt% glutaraldehyde disinfectant solution and add it to the preheated evaporating dish. Cover the mask D on top of the evaporation dish, with its outer surface facing down, facing the evaporation dish, and then paste the test paper wrapped with waterproof and breathable material on the inner surface of the mask D, with the test paper facing down. Place a 100ml evaporating dish on top of the mask as a lid. The two evaporating dishes are aligned and sealed with a heavy object to allow glutaraldehyde vapor to pass through mask D to observe the protective ability of mask D against glutaraldehyde vapor. After heating and fumigating for about 3 hours, observe the discoloration of the glutaraldehyde test paper and the mask.

The comparative example uses 3M ^TM 8247 organic vapor and particle protective mask, which conducts the above experiments under the same conditions. In order to ensure the adsorption performance of activated carbon, the mask was placed in a drying dish and vacuum dried for more than 24 hours before the test.

Testing of protective limit performance of hypochlorous acid chlorine-containing disinfectants

The experimental method for the protective performance of hypochlorous acid chlorine-containing disinfectant is similar to the protective performance test of glutaraldehyde disinfectant. The difference is that a chlorine-containing disinfectant with an effective chlorine concentration of 30,000 ppm is used, and the test paper used is a chlorine test paper. Set the water bath at about 45°C and heat and fumigate for 4 hours. For the comparison example, 3M ^TM 8246 acid gas and particle protective mask was used.

Testing of protective limit performance of peracetic acid disinfectant

The experimental method for the protective performance of peracetic acid disinfectant is similar to the test for the protective performance of chlorine-containing disinfectant. The difference is that 15000 ppm peracetic acid disinfectant is used, and the test paper is peracetic acid test paper. Set the water bath at about 45°C, heat and fumigate for 6 hours, then close the water bath and use the residual heat to leave it for 17.5 hours. For the comparison example, 3M ^TM 8246 acid gas and particle protective mask was used.

Hydrogen peroxide disinfectant protective limit performance testing

The experimental method for the protective performance of hydrogen peroxide disinfectant is similar to the protective performance test of chlorine-containing disinfectant. The difference is that 30,000 ppm hydrogen peroxide disinfectant is used, and the test paper is a hydrogen peroxide test paper. Set the water bath at about 45°C, heat and fumigate for 6 hours and then close the water bath. For the comparison example, 3M ^TM 8246 acid gas and particle protective mask was used.

Testing of protective limit performance of chlorine dioxide disinfectant

Experimental method for the protective performance of chlorine dioxide disinfectant The test method is similar to the protective performance test of chlorine-containing disinfectant. The difference is that 20,000 ppm chlorine dioxide disinfectant is used, and the test paper is hydrogen peroxide test paper. Set the water bath at about 45°C, heat and fumigate for 6 hours, then close the water bath and use the residual heat to leave it for 18 hours. For the comparison example, 3M ^TM 8246 acid gas and particle protective mask was used.

In the above protective limit performance test, the liquid used for fumigation in the evaporating dish can also be added by gradual titration until the test paper changes color, so as to simulate the situation of mask D after repeated use. Compared with the comparative example Compare.

Table 6 Protection limit performance and color rendering performance of mask D and 3M ^TM occupational protective mask

In this embodiment, 3M ^TM masks are used as a comparative example. The specific masks used include 3M ^TM 8246 type masks and 3M ^TM 8247 type masks.

The above examples can confirm that the mask D of the present invention is significantly better than the comparative example in protecting the volatile gases of trichloroisocyanuric acid, chlorine dioxide, and glutaraldehyde disinfectant. Regarding the protection against peracetic acid, the mask D of the present invention is equivalent to the comparative example. As for the protection against hydrogen peroxide, the mask D of the present invention has a relatively long-lasting effect. For example, the test paper on the mask D did not change color until 6 hours after the experiment was carried out. The above results show that in the environment of the above-mentioned high concentration of irritating gas, the mask of the present invention has strong protective ability.

In addition, the inventor unexpectedly discovered that due to the use of amino acids in the formula of the mask composition, the mask of the present invention will produce a specific discoloration reaction under the irritating gas environment of high concentrations of disinfectants, that is, under the irritating gas environment of different disinfectants, After repeated use in the environment, the floor mask of the present invention will produce different discoloration reactions. For example, for chlorine-containing disinfectants (such as hypochlorous acid disinfectants or chlorine dioxide disinfectants), the mask of the present invention will turn red after repeated use. As another example, for peroxide disinfectants, the mask of the present invention will turn dark yellow after repeated use. For another example, regarding glutaraldehyde disinfectant, the mask of the present invention will turn dark brown after repeated use. In addition, after the mask of the present invention is placed in the air for a period of time, the active ingredients in the mask will oxidize and the mask will turn yellow. The degree of color change mentioned above is related to the concentration of volatile gases in the disinfectant and the use time of the mask. Among them, the degree of color change can also reflect the time that the mask of the present invention can continue to be used. For example, the deeper the color change of the mask, the shorter the time the mask of the present invention can continue to be used.

Therefore, the mask of the present invention can not only efficiently absorb and neutralize irritating gases in various disinfectants, but can also perform a discoloration reaction according to the state of the active ingredients in the mask, and timely reflect how long the mask can continue to be used.

Example 11 Heat dissipation ability of the mask of the present invention

The mask of the present invention can not only effectively absorb and neutralize irritating gases in disinfectants, but also has additional heat dissipation properties. Among them, the heat dissipation performance is specifically achieved through the following methods.

(1) Provide the mask of the present invention;

(2) The tester wears the mask in step (1) for 45 minutes;

(3) The tester wears a mask and takes a thermal image temperature measurement;

Usually when a mask wearer exhales air from the nostrils, the heat is blocked by the mask and transferred to the facial skin, so the facial skin in contact with the mask has higher humidity and temperature. The above steps reflect the impact of different masks on the tester's facial temperature by measuring the temperature of the tester's face when wearing and taking off the mask.

Specifically, the mask A of the present invention is used as an example, and the disposable medical non-woven nursing mask and cotton mask are used as a comparative example to detect the above temperatures respectively. Among them, Figure 5-a shows the thermal image when wearing a disposable medical non-woven nursing mask, Figure 5-b shows the thermal image of the facial skin taken at the moment when the above mask is taken off; Figure 6-a shows the thermal image when wearing a cotton mask. Thermal image, Figure 6-b shows the thermal image of facial skin taken at the moment when the above mask is taken off; Figure 7-a shows the thermal image when wearing the mask A of the present invention, Figure 7-b shows the thermal image taken at the moment when the above mask is taken off Thermal image of facial skin. In particular, it can be seen from Figure 7-a and Figure 7-b that the skin surface temperature of the part of mask A that is in contact with the skin is significantly lower than that of the non-contact part.

Table 7 Comparative test on the cooling effect of mask A according to the embodiment of the present invention and the reference mask

The above examples can confirm that the mask of the present invention not only has the above-mentioned ability to absorb and neutralize irritating gases, but also has obvious heat dissipation performance. For example, when a tester wears the mask A of the present invention, the maximum temperature of the tester's facial skin is 36.6°C. The above-mentioned temperature is close to the body temperature of the human body, so the wearer will not feel stuffy when wearing the mask of the present invention. In addition, when wearing the mask of the present invention for a long time, the temperature of the facial skin will not increase. Therefore, the mask of the present invention has excellent heat dissipation performance.

Example 12 Storage of the composition solution of the present invention

The composition of the present invention can be stored in a vacuum spray bottle with a piston structure at the bottom, or in a traditional spray bottle with a straw as shown in Figure 8. For example, see the spray bottle shown in Figure 8, where 1001 is a transparent plastic bottle with a wall thickness of 0.4-5mm; 1002 is a cock spray button; 1003 is a rotatable nozzle; 1004 is a suction tube; 1005 is a liquid sealing agent, with To isolate the composition solution and air; 1006 is the composition solution of the present invention. Such a packaging structure can reduce the contact area between the composition and air. Preferably, the capacity of the spray bottle is 20 ml, the wall thickness is 1.2 mm, the liquid sealant uses 0.6 ml of liquid paraffin, and the liquid sealant thickness is 1.5 mm. When taking the liquid, just press the cock spray button 1002 to spray the composition. In a preferred embodiment, approximately 0.094ml of liquid can be sprayed out each time the key is pressed. In addition, a vacuum spray bottle with a piston AS at the bottom can also be used to store the composition solution of the present invention.

In this embodiment, the composition solution is a 2.7% (W/V) vitamin C solution and a composition solution of mask E (see Example 2). Store the above composition solution in a light-transmitting plastic bottle and a light-transmitting AS vacuum spray bottle for a period of time. The storage environment is an indoor room with a north-facing window, no direct sunlight, but with natural light and fluorescent indoor lighting. Then take 1ml of each solution and titrate it with 1000ppm chlorine-containing disinfectant prepared from trichloroisocyanuric acid tablets. Use the consumption of the titrant (ml) as the dosage unit of active substance concentration C and obtain it based on relevant data and the following formula The half-life of an active ingredient (such as a vitamin).

lg C＝-(kt/2.303)+lgC ₀

t _1/2 =0.693/k

Table 8 Examples of the effects of liquid sealants, grape seed extracts, and packaging materials on reducing the oxidation of vitamin C solutions by air

In the above storage experiments, the formulas of vitamin C solution or mask E were stored in different ways. For example, plastic bottles can be used to store vitamin C solution. For another example, a plastic bottle can be used to store the vitamin C solution, and a liquid sealing agent can be added to the plastic bottle for further sealing. For another example, an AS vacuum spray bottle can be used to store the formula of mask E; wherein the formula of mask E contains grape seed extract (proanthocyanidins).

The test results of the above examples can confirm that using the container shown in Figure 8 to store the composition solution of the present invention, the composition of the present invention can be stored for a long time without deterioration, with a half-life of 443-3253 days, up to 3253 days. .

Among them, the inventor unexpectedly discovered that because the grape seed extract in the formula of Mask E has a maximum absorbance at 546nm, it can absorb blue-violet light, thus exhibiting the effect of a brown sunscreen. This composition formula also greatly extends the shelf life of light-sensitive vitamin C, with a half-life of up to 3253 days. This makes the composition of the present invention have significant industrial applicability and commercial value.

In addition, according to the half-life of the vitamin C aqueous solution and the aqueous solution of the composition of the present invention (such as the aqueous solution of the mask E formula), it can be seen that compared with vitamin C, the composition of the present invention obviously has significantly better stability.

Preserving the composition of the present invention in the above manner not only extends the storage time of the composition of the present invention, but also allows the composition of the present invention to be accessed at any time. It also provides a method for quickly preparing the mask of the present invention, which includes:

(1) Provide the composition solution of the present invention;

Among them, the mask used in step (2) can be a commercially available disposable mask or a cotton mask, etc.

For example, refer to the process of preparing the mask of the present invention shown in Figure 9, in which the spray bottle body 1001 is tilted, and the rotatable nozzle 1003 is adjusted to a distance of about 5-10cm from the mask D, and the front and back sides of the cotton mask are Spray the composition liquid evenly, press the spray button 17 times each, a total of 34 times, approximately 3.2 ml of the composition liquid can be sprayed, thereby quickly completing the preparation of the occupational exposure protective mask D.

It can be seen that the spray bottle containing the composition solution of the present invention can be stored separately from the ordinary mask. When necessary, the composition of the present invention can be immediately sprayed on the inside and/or outside of the ordinary mask to obtain the mask of the present invention. To absorb irritating gases in disinfectants. Therefore, the mask can be stored in a dry environment and sprayed with the solution only when used. Since the middle layer of existing masks is mostly made of polypropylene melt-blown cloth and electret electrostatic process, such masks must be stored in an extremely dry environment to avoid loss of static charge. The above method can not only quickly obtain the mask of the present invention, but also store the composition and the mask separately under different conditions to further extend the storage time of the composition and the mask.

Example 13 Disinfection effect of the composition of the present invention and its compatibility with alcohol-based disinfectants

In order to verify whether the composition of the present invention will have an impact on the performance of alcohol-based disinfectants, and to determine whether the composition of the present invention has potential inhibitory effect on microbial activity, the present invention designs relevant tests to detect the performance of the composition and alcohol-based disinfectants. compatibility. Among them, the disinfection effect of the composition and its compatibility with alcohol-based disinfectants were tested by the following methods.

(1) Take a 50mL Erlenmeyer flask or a 15mL test tube;

(2) According to the sequence of Table 9 below, add water and/or disinfecting alcohol and/or propylene glycol and/or composition 1 (water-glycerin solvent, without protein coagulant and plant extract) to the container in step (1). ) and/or composition 2 (water-propylene glycol solvent, containing protein coagulant and plant extract); wherein, the added protein coagulant is glucono-delta-lactone, and the added plant extract is grape seed extract ;

(3) Add egg white to the mixture in step (3);

During the experiment, the pH of compositions 1 and 2 was controlled to be about 5.5-6.2.

Table 9 Egg white precipitation method test composition and compatibility of disinfectant alcohol

According to the above-mentioned experiments A and B, it can be seen that after the water-glycerin solvent composition containing no protein coagulant and plant extract is mixed with egg white (experiment A), the container is a clear colloid. It can be seen that composition 1 has good protein protection effect. In addition, when Composition 1 is mixed with disinfectant alcohol (Experiment B), the effect of protein denaturation and precipitation can still be achieved, so Composition 1 will not reduce the effect of disinfectant alcohol.

According to the above experiments C and D, it can be seen that composition 2 (water-propylene glycol solvent, containing protein coagulant and plant extract) is mixed with egg white (experiment C), resulting in a slow precipitation effect of protein. It can be seen from this that composition 2 can be used to slowly inhibit the biological activity of microbial surface proteins. In addition, when composition 2 is mixed with disinfectant alcohol (experiment D), that is, when protein coagulant and plant extract are added to the composition, the protein denaturation and precipitation effect can still be achieved. It can be seen that when Composition 2 is used in combination with disinfectant alcohol, the addition of protein coagulants and plant extracts will not only not affect the effect of disinfectant alcohol, but can also work synergistically with disinfectant alcohol to quickly inhibit protein activity while also sustaining the effect. Inhibit protein activity, thereby achieving stronger disinfection effect and achieving long-term disinfection.

In addition, according to Test E, it can be seen that only adding propylene glycol can achieve the effect of quickly denaturing and precipitating proteins. Therefore, high concentrations of propylene glycol also have strong disinfection effects.

According to the above content, it can be known that in the composition of the present invention, propylene glycol can be used as a moisture absorbing agent, and the moisture absorbing agent can make the composition form a solution state after absorbing moisture in the air. It can be seen from this that the water-propylene glycol system in this embodiment corresponds to the aqueous composition solution system of the present invention. Therefore, by adding protein coagulants and plant extracts, the composition of the present invention will not only not affect the disinfection effect of disinfectant alcohol, but can also perform collaborative disinfection, quickly inhibit protein activity and achieve long-term disinfection, achieving stronger and lasting disinfection. Effect.

In addition, moisture-absorbing agents (such as propylene glycol) and plant extracts (such as grape seed extract) are also commonly used substances in skin care products, and according to the above experiments, it is known that they also have the effect of inhibiting protein activity, so they are added to the composition of the present invention. Adding the above-mentioned plant extracts and moisture attractants can reduce the use of alcohol-based disinfectants, thereby reducing their irritation to the skin.

The above are only specific embodiments of the present invention, and are not intended to limit the patent scope of the present invention. Any equivalent transformations using the present invention, or direct or indirect application in other related technical fields, are equally included in the present invention. within the scope of patent protection.

Finally, I would like to thank my friends and leaders, especially Hu Yanfeng (who taught me how to use graduated pipettes for rapid titration), Sun Chaorong, Du Yi, Huang Yicheng, Li Yiming, Bu Shuhong, Yang Ling, Liu Fang, Yu Ying, Chen Shuyan, Pan Zhihong, Zhang Jian, Zhou Jia, Lu Xiaotong, Liu Haitao, Liu Ying, Chen Feng, Tao Xiaoqin (responsible for the microbial identification part), Xu Yulan, Xu Ming (I'm sorry, my sense of smell is not very good, Xu Ming is our work support staff, she (who has a particularly good sense of smell, so he undertook the work of qualitative testing), Chen Lun (responsible for taking thermal imaging photos), Bu Liping and others provided enthusiastic help.

Claims

A composition characterized in that, based on the total weight of the composition, the composition contains:

(A) about 0.1 to 99% by weight of biosorbent and

(B) About 0.0001-99% by weight of moisture attractant;

Preferably, the composition contains:

(A) about 26-46% by weight of biosorbent and

(B) About 44-64% by weight of moisture attractant;

More preferably, the composition contains:

(A) approximately 36% by weight of biosorbent and

(B) About 54% by weight of moisture attractant.
The composition of claim 1, characterized in that:

The biosorbent is selected from one or more of the following:

(a) Compounds containing enol structure;

(b) Compounds containing sulfhydryl groups;

(c)Amino acids;

(d) Biological enzymes.
The composition of claim 2, characterized in that:

The compound containing an enol structure is a 3-18 membered cyclic enol compound and its derivatives containing 0, 1 or 2 additional heteroatoms independently selected from oxygen, sulfur, nitrogen and phosphorus. The ring can be any Optionally substituted by one or more substituents selected from the group consisting of C 1-10 alkyl, C 3-10 cycloalkyl, aryl, aryl-C 1-4 alkyl, wherein each alkyl, Cycloalkyl and aryl are unsubstituted or at least one independently selected from hydroxyl, CN, amino, acyl, carboxyl, halogen, C 1-10 alkyl, C 3-10 cycloalkyl, C 1-10 alkyl Substituent substitution of oxygen group; vinyl alcohol; acetol;

Preferably, one or more selected from the group consisting of vitamin C, vitamin B6, vitamin B9, catechol, vinyl alcohol, acetol, stigmastenol, tocotrienol, euphorbienol, erythorbic acid, Ascorbyl palmitate, ascorbyl glucoside and their derivatives;

More preferably, one or more selected from the group consisting of vitamin C, vitamin B6, and vitamin B9;

Vitamin C is particularly preferred.
The composition of claim 2 or 3, characterized in that,

The thiol-containing compound is selected from the group consisting of cysteine, thioglycolic acid, dimercaprol, sodium dimercaptopropanesulfonate, tiopronin, disodium dimercapto, cysteamine, penicillamine, lipoic acid, and methcapto propionic acid, glutathione, alpha-lipoic acid, dithiothreitol and combinations thereof;

Preferably selected from N-acyl-cysteine, N-alkyl-cysteine, dimercaprol, disodium dimercaptobutyrate, dithiothreitol and combinations thereof;

More preferably, it is selected from N-acetyl-L-cysteine, N-methyl-L-cysteine, N-ethyl-L-cysteine, dimercaprol, disodium dimercapto, dithiothreitol and combinations thereof;

Particularly preferred is N-acetyl-L-cysteine.
The composition according to any one of claims 2-4, characterized in that,

The amino acid is selected from alanine, valine, leucine, isoleucine, methionine, proline, tryptophan, serine, tyrosine, cysteine, and phenylalanine , asparagine, glutamine, threonine, aspartic acid, glutamic acid, lysine, arginine, histidine, glycine and combinations thereof;

Preferably selected from glycine, glutamic acid and combinations thereof;

More preferred is glycine.
The composition according to any one of claims 2-5, characterized in that,

The biological enzyme is selected from catalase and horseradish peroxidase;

Catalase is preferred.
The composition according to any one of claims 1-6, characterized in that,

The moisture-drawing agent is selected from the group consisting of diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, glycerol polyether, xylitol, sorbitol, propylene glycol glucoside, sodium lactate and combinations thereof;

Preferably selected from glycerol, propylene glycol and combinations thereof;

More preferred is propylene glycol.
The composition according to any one of claims 2-7, characterized in that,

Based on the total weight of the composition,

The content of the compound containing an enol structure is about 0.01-95% by weight, preferably about 1-50% by weight, and more preferably about 13.6% by weight;

The content of the thiol-containing compound is about 0.0001-99% by weight, preferably about 0.1-20% by weight, and more preferably about 3.28% by weight;

The content of the amino acid is about 0.0001-95% by weight, preferably about 0.0001-85% by weight, and more preferably about 20% by weight;

The content of the biological enzyme is about 0.0000001-20% by weight, preferably about 0.02-0.2% by weight;

The content of the moisture attracting agent is about 0.0001-99% by weight, preferably about 44-64% by weight, and more preferably about 54% by weight.
The composition according to any one of claims 1-8, characterized in that,

Based on the total weight of the composition,

The composition further includes at least one of the following ingredients:

(e) about 0.00000001-1% by weight of preservative;

(f) About 0.00001-90% by weight of acid-base buffer;

(g) about 0.000001-5% by weight antioxidant;

(h) about 0-1% by weight of emulsifier;

(i) About 0-20% by weight liquid sealant;

(j) about 0-20% by weight of protein coagulant;

(k) about 0-20% by weight of plant extracts;

(l) About 0.0001-2% by weight of odor masking agent;

Preferably, the composition further comprises at least one of the following ingredients:

(e) about 0.001-0.5% by weight of preservative;

(f) About 0.01-5% by weight of acid-base buffer;

(g) about 0.001-0.04% by weight antioxidant;

(h) about 0.001-0.01% by weight of emulsifier;

(i) About 1% by weight of liquid sealant;

(j) about 0.0001-20% by weight of protein coagulant;

(k) About 0.0001-20% by weight of plant extract;

(l) About 0.01-0.9% by weight of odor masking agent.
An aqueous solution, characterized in that it contains the composition of any one of claims 1-9;

Preferably, based on the total weight of the aqueous solution,

The content of the composition is about 30-80% by weight, more preferably about 56-76% by weight, particularly preferably about 66% by weight.
A base material characterized by:

The substrate contains the composition of any one of claims 1-9,

The substrate is selected from non-woven fabrics, metal mesh, glass fiber, cotton cloth, linen cloth and filter cotton, preferably non-woven fabrics.
A multi-layer material A, characterized in that the multi-layer material contains

The substrate according to claim 11 is used as a base material;

The activated carbon layer serves as the first filter layer;

Preferably, a second filter layer is further included between the base material and the first filter layer.
The multilayer material of claim 12, characterized in that:

The second filter layer is selected from non-woven fabrics, metal mesh, and glass fiber;

Preferably non-woven fabric;

Melt-blown nonwoven fabric is particularly preferred.
A multi-layer material B, characterized in that the multi-layer material contains

The base material according to claim 11 as the first base layer material;

an intermediate isolation layer comprising a porous breathable material that is impervious to water;

The second base material contains biological enzymes, moisture absorbing agents, preservatives and acid-base buffers.
The multilayer material of claim 14, characterized in that:

The porous breathable material is selected from polyester filter cotton, glass wool, rock wool, air filter cotton, and foam sponge;

Polyester filter cotton is preferred;

and / or

The thickness of the middle isolation layer is about 0.1-15mm;

Preferably it is about 3mm.
A mask, characterized in that the mask includes the base material of claim 11 or the multi-layer material of any one of claims 12-15.
The method for preparing the mask of claim 16, comprising:

(1) Provide the composition solution of the present invention;

(2) Spray the composition liquid of step (1) onto the inside and/or outside of the mask by spraying.