WO2023190293A1

WO2023190293A1 - Viscous nutritional composition

Info

Publication number: WO2023190293A1
Application number: PCT/JP2023/012115
Authority: WO
Inventors: 宏樹佐藤; 泰代谷口; 康次郎井樋; 弘西谷
Original assignee: ニュートリー株式会社
Priority date: 2022-03-30
Filing date: 2023-03-27
Publication date: 2023-10-05
Also published as: JPWO2023190293A1

Abstract

Provided is a viscous nutritional composition that can be used without effort two or three times per day by, for example, a patient undergoing rehabilitation or long-term treatment.　This viscous nutritional composition contains nutrients that include proteins, lipids, and carbohydrates. The density (quantity of heat/g) of the viscous nutritional composition is 0.9–1.1 kcal/g, the quantity of heat per unit is 450–550 kcal/unit, and two or three units are to be used per person per day.

Description

Thick nutritional composition

The present invention relates to a thick nutritional composition.

Enteral nutrition is more physiological than parenteral nutrition, maintains the original functions of the gastrointestinal tract, such as digestion and absorption, and the function of the intestinal immune system, and can be safely managed with fewer infectious complications. . It is an important nutritional administration method for patients who have difficulty taking oral intake due to significant decline in masticatory/swallowing function or impaired consciousness.
Enteral feeding methods include nasal tube feeding and gastrostomy tube feeding, depending on the route of administration. Nutrient compositions come in liquid and semi-solid forms, but both methods of administration allow for administration by natural fall, while also suppressing aspiration pneumonia caused by gastroesophageal reflux to some extent. A thick nutritional composition is known as one that can provide this (Patent Document 1).

Patent No. 6347954

Many conventional commercially available thick nutritional compositions have a calorific value of 200 to 400 kcal/piece (Patent Document 1). However, in the case of patients undergoing rehabilitation, depending on their condition, the required amount of energy is about 1.2 to 1.5 times the normal amount, which is 1,300 to 1,700 kcal/day, and conventional commercial products alone cannot There are cases where three meals for breakfast, lunch, and dinner are not enough to meet the required energy, and liquid food is added as needed. This poses a problem in that it increases the effort and time required for administration.
Furthermore, in the case of patients undergoing long-term treatment, nutritional management is usually carried out at 900 to 1100 kcal/day. In this case, in recent years, instead of having three meals a day, one in the morning, one in the afternoon, and one in the evening, nutrition is taken through a tube for two meals in the morning and in the evening. Oral intake training may be performed to transition to oral administration. In this case, conventional commercially available products (approximately 200 to 400 kcal/bottle) require the use of two bottles per meal, either in the morning or in the evening, which increases the effort and time required to administer the drug. .
Therefore, there is a need for a thick nutritional composition that patients undergoing rehabilitation or long-term treatment can use two or three bottles per day without any hassle.

The above problems are solved by the following invention.
(1) A thick nutritional composition containing nutrients including proteins, lipids, and carbohydrates, wherein the concentration of the thick nutritional composition is 0.9 to 1.1 kcal/g, and the concentration of the thick nutritional composition is 0.9 to 1.1 kcal/g. It is a thick nutritional composition with a calorific value of 450 to 550 kcal/piece and is used 2 to 3 bottles per person per day.
(2) The thick nutritional composition according to (1) above, which has a pH of 3.0 to 4.5.
(3) The thick nutritional composition according to (1) or (2) above, which contains slowly digestible dextrin and has a blending amount of 10.0 to 17.2 g/100 kcal.
(4) The thick nutritional composition according to any one of (1) to (3) above, which has a viscosity at 25° C. of 1,000 to 4,000 mPa·s.
(5) The thick nutritional composition according to any one of (1) to (4) above, wherein the blended amount of protein is 2.7 to 5.5 g/100 kcal.
(6) A thick nutritional composition containing nutrients including proteins, lipids, and carbohydrates, wherein the concentration of the thick nutritional composition is 0.9 to 1.1 kcal/g, and the concentration of the thick nutritional composition is 0.9 to 1.1 kcal/g. It is a thick nutritional composition with a calorific value of 450 to 550 kcal/piece.
(7) A nutritional composition containing nutrients including proteins, lipids, and carbohydrates and used 2 to 3 bottles per person per day, wherein the concentration of at least one of the nutritional compositions is 0.9 to 1. This nutritional composition is a thick nutritional composition with a calorific value of .1 kcal/g and a calorific value of 450 to 550 kcal/piece.

The thick nutritional composition of the present invention has an appropriate viscosity while containing nutrients such as protein, lipid, and carbohydrate, and has a calorific value of 2 to 3 bottles per day. In addition, the effort and time required to administer the nutritional composition can be reduced.
Specifically, it is possible to provide a thick nutritional composition that satisfies the necessary energy with three bottles in the morning, afternoon, and evening for patients undergoing rehabilitation. This makes it possible to meet the necessary energy efficiently, which not only reduces labor but also allows more time for rehabilitation and care.
More specifically, it is possible to provide a thick nutritional composition that can meet the energy needs of patients undergoing long-term treatment with two bottles, one in the morning and one in the evening. This makes it possible to efficiently meet the required energy, which not only reduces effort and time, but also allows time for oral intake training.
In addition, the thick nutritional composition of the present invention is a thick nutritional composition that does not require rapid administration even when directly connected to a PEG (gastrostomy) catheter due to natural drop, and does not require water administration. It is a thing. Therefore, the patient receiving the drug can reliably and easily ingest nutrients without causing diarrhea. Furthermore, because it has a certain viscosity, unlike liquids, it takes about 30 minutes to stay in the stomach even when administered using a drop or through a nasal tube using a pressurized pump. Because it is administered in a vacuum, reflux is less likely to occur than with liquid nutritional compositions.
Furthermore, the thick nutritional composition of the present invention can suppress bacterial growth within the PEG catheter after administration of the nutritional agent by setting the pH to an acidic range.
In addition, the thick nutritional composition of the present invention can suppress rapid increases in blood sugar by containing slowly digestible dextrin.
This specification includes the content described in the specification and/or drawings of the Japanese patent application, Japanese Patent Application No. 2022-55016, which is the basis of the priority of this application.

Hereinafter, the thick nutritional composition of the present invention will be explained in detail.
The thick nutritional composition of the present invention has a calorific value of 450 to 550 kcal/bottle or at least one bottle. If the calorific value per bottle is lower than 450 kcal/bottle, it is preferable because patients undergoing rehabilitation are expected to use 4 bottles per day, and patients undergoing long-term treatment are expected to use 2 bottles per meal. do not have. Moreover, if the amount exceeds 550 kcal/piece, it is not preferable because the amount of calories to be taken in one meal is too large.

The thick nutritional composition of the present invention has a concentration (specifically, calorific value/g, calorific value per g) of 0.9 to 1.1 kcal/g, preferably 0.95 to 1.05 kcal/g. It is. If the concentration (calorific value/g) is less than 0.9 kcal/g, it is not preferable because the water content of the thick nutritional composition will increase and the amount of nutrients administered to the patient may decrease, resulting in nutritional deficiency. If the concentration (calorific value/g) exceeds 1.1 kcal/g, the water content of the thick nutritional composition will decrease, and water will be added and administered through the PEG (gastrostomy) catheter, increasing the risk of bacterial infection. Therefore, it is not desirable.
The moisture content of the thick nutritional composition of the present invention is preferably 30 to 95% by mass, preferably 30 to 95% by mass, and more preferably 40 to 90% by mass.

Note that the amount of heat can be adjusted by appropriately setting the amounts of carbohydrates, lipids, proteins, dietary fibers, etc. added. In addition, in this specification, "calorific value" is a value calculated with reference to the energy conversion coefficient of Atwater. Specifically, it is calculated as calorie = (4kcal x carbohydrate content) + (9kcal x lipid content) + (4kcal x protein content) + (2kcal x dietary fiber content). Concentration (calorific value/g) is expressed as kcal per gram of sample.

"Thickened" in the thickened nutritional composition of the present invention means that it has a viscosity of 1,000 to 4,000 mPa·s. In the present specification, viscosity is measured according to the method described in the 8th edition of the Food Additives Official Standards "B. General Test Methods, 28. Viscosity Measurement Method 2nd Method Rotational Viscometer Method". For example, it refers to a value measured using a B-type rotational viscometer DV-II+Pro (Brookfield), RB80L (Toki Sangyo Co., Ltd.), or the like.

The viscosity of the thick nutritional composition of the present invention is preferably 1,000 to 4,000 mPa·s, preferably 1,500 to 3,000 mPa·s. If the viscosity is lower than 1,000 mPa·s, when directly connected to a PEG catheter and administered by natural drop, the thick nutritional composition will be rapidly administered to the stomach, causing symptoms such as diarrhea, which is not preferable. If the viscosity exceeds 4,000 mPa·s, the fluidity of the thick nutritional composition will deteriorate and administration will take too much time, which is not preferable.

The pH of the thick nutritional composition of the present invention is preferably 3.0 to 4.5, preferably 3.5 to 4.0. If the pH is lower than 3.0, the acidity becomes strong and a refreshing feeling cannot be obtained, which is not preferable. If the pH exceeds 4.5, it becomes difficult to suppress the growth of bacteria within the PEG catheter when the nutritional composition is used, which is not preferable.

The pH of the thick nutritional composition of the present invention can be adjusted by appropriately setting the amount of a pH adjuster, acidulant, etc. added. In addition, in this specification, pH is the value measured according to the method described in "B. General test method, 31. pH measurement method" of the 8th edition of the Food Additives Official Standards.

The "slowly digestible dextrin" shown in the thick nutritional composition of the present invention is a dextrin that causes a lower increase in blood sugar level after ingestion than normal maltodextrin. Specifically, highly branched dextrins with many branched structures consisting of z and α-1,6 bonds are preferred. Commercially available products include HBD-20 (Matsuya Chemical Industry Co., Ltd.).

The amount of "slowly digestible dextrin" shown in the thick nutritional composition of the present invention is preferably 10.0 to 17.2 g/100 kcal (0.36 to 0.76 kcal/g). If the blending amount is lower than 10.0 g/100 kcal (0.36 kcal/g), there is a possibility that sufficient amount of heat cannot be obtained. If it exceeds 17.2 g/100 kcal (0.76 kcal/g), the carbohydrate supply becomes excessive and may induce diabetes.

As the carbohydrate used in the thick nutritional composition of the present invention, in addition to slow-digesting dextrin, any of various known carbohydrates that have been conventionally used in nutritional compositions can be used. For example, monosaccharides such as glucose, fructose, and galactose, disaccharides such as sucrose, lactose, maltose, isomaltose, and trehalose, starch (amylose, amylopectin), Polysaccharides such as dextrins, starch syrup, reduced starch syrup, honey, isomerized sugar, invert sugar, oligosaccharides (isomalto-oligosaccharides, reduced xylo-oligosaccharides, reduced gentio-oligosaccharides, xylooligosaccharides, gentio-oligosaccharides, nigerooligosaccharides, theandeo-oligosaccharides, soybean oligosaccharides) ), powdered candy, sugar alcohols (maltitol, erythritol, sorbitol, palatinit, xylitol, lactitol, etc.), sugar-bound starch syrup (coupling sugar), etc. These may be used alone or in combination of two or more.

In addition, sweetening ingredients that are conventionally known or that will become known in the future can also be used in place of sugars. Specifically, sweet ingredients such as aspartame, acesulfame potassium, sucralose, alitame, neotame, licorice extract (glycyrrhizin), saccharin, sodium saccharin, stevia extract, and stevia powder may be used.

The thick nutritional composition of the present invention preferably has a protein content of 2.7 to 5.5 g/100 kcal (0.10 to 0.24 kcal/g), preferably 3.3 to 5.0 g/100 kcal (0.10 to 0.24 kcal/g). It is 100kcal (0.12-0.22kcal/g). If the amount of protein blended is less than 2.7 g/100 kcal (0.10 kcal/g), it is not preferable because the required amount of protein cannot be ingested. If the amount of protein added exceeds 5.5 g/100 kcal (0.24 kcal/g), it is not preferable because it may place a burden on the kidney function of elderly people.

As the protein used in the thick nutritional composition of the present invention, any of various known proteins that have been conventionally used in nutritional compositions can be used. Furthermore, in the present invention, proteins include not only vegetable proteins and animal proteins, but also amino acids and peptides.

Examples of vegetable proteins include proteins contained in grains such as rice, legumes such as soybeans and tofu, and the like. In addition, soybean protein may have health functions such as binding to bile acids and promoting the excretion of cholesterol. Examples of animal protein include proteins contained in eggs, meat, seafood, milk, and the like.

Among these, it is preferable to use whey protein made from milk (whey), casein protein contained in milk, and soybean protein, and it is more preferable to use whey protein. Examples of the whey protein include whey protein concentrate (WPC), whey protein isolate (WPI), hydrolyzed whey peptide (WPH), and the like. WPC, WPI, soybean protein, etc. may be commercially available. Examples of commercially available products include WPI8855 (manufactured by Fonterra), WPI8899 (manufactured by Fonterra), WPI895 (manufactured by Fonterra), WPC392 (manufactured by Fonterra). ), WPC80 (manufactured by Fonterra), WPC7009 (manufactured by Fonterra), WPC164 (manufactured by Fonterra), WPC162 (manufactured by Fonterra), WPC132 (manufactured by Fonterra), WPC472 (manufactured by Fonterra), Prolina 800 (Fuji Oil (manufactured by Fuji Oil Co., Ltd.), New Fuji Pro 3000 (manufactured by Fuji Oil Co., Ltd.), New Fuji Pro 1700N (manufactured by Fuji Oil Co., Ltd.), and the like.

Amino acids include essential amino acids such as valine, leucine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan, histidine, and glycine, alanine, serine, cysteine, asparagine, glutamine, proline, tyrosine, aspartic acid, glutamic acid, arginine, etc. Examples include non-essential amino acids such as carnitine.

As the peptide, one in which two or more of the above amino acids are polymerized via a peptide bond (amide bond) can be used. The peptide may be a dipeptide, tripeptide, oligopeptide (having about 10 amino acids), or polypeptide (having tens to hundreds of amino acids). The polypeptides include proteins such as plant proteins and animal proteins. Note that some oligopeptides, such as lactotripeptide, caseindodecapeptide, and baryltyrosine-containing sardene peptide, may have health functions such as antihypertensive effects.

The above-mentioned proteins, amino acids, or peptides may be used alone or in combination of two or more.

In the thick nutritional composition of the present invention, its viscosity is preferably adjusted by agar having a jelly strength of 10 to 120 g/cm ² and pectin having a degree of esterification of 50 to 75%.

The "jelly strength" shown in the thick nutritional composition of the present invention is determined by leaving a 1.5% agar aqueous solution at 20°C for 15 hours, measuring the hardness of the solidified gel, and measuring the surface area of the agar gel by 1 ^cm2. It is the maximum weight (g) that can be withstood for 20 seconds. The hardness of the gel can be measured using a commonly used rheometer or the like.

The agar that can be used in the thick nutritional composition of the present invention is not particularly limited, and those produced by conventional methods can be used. In general, agar is made by freezing and drying the mucilage of red algae such as Amanita spp. The agarose and agaropectin have a structure in which galactose and 3,6-andehydrogalactose are alternately polymerized. The properties of agar may vary depending on the degree of polymerization and molecular weight of agarose and agaropectin, the amount of sulfate groups and pyruvic acid groups in the agar, etc., but in the thick nutritional composition of the present invention, there are no particular limitations. Either one may be used.

The jelly strength of agar that can be used in the thick nutritional composition of the present invention is preferably 10 to 120 g/cm ² . If the jelly strength of agar is lower than 10 g/ ^cm2 , the molecular weight distribution of the agar is in a small range, and the gelling power is extremely suppressed, so the viscosity of the thick nutritional composition decreases, making it difficult to use the PEG catheter. This is undesirable because it flows rapidly and may cause the nutritional composition to leak from around the PEG catheter or cause diarrhea in the patient. When the jelly strength of agar exceeds 120 g/ ^cm2 , the agar has a large molecular weight distribution and has very strong gelling power, so the viscosity of the thick nutritional composition increases and the natural drop from the PEG catheter increases. When the nutritional composition is administered using the PEG catheter, it takes a long time to pass through the PEG catheter, which is not preferable.

The amount of agar that can be used in the thick nutritional composition of the present invention is preferably 0.04 to 0.20% by mass, preferably 0.06 to 0.20% by mass based on the total amount of the thick nutritional composition. It is 0.10% by mass. If the amount of agar added is less than 0.04% by mass, the solid content of the thick nutritional composition will not be dispersed but will precipitate, which may cause blockage of the PEG catheter, which is not preferable. If the amount of agar exceeds 0.20% by mass, the viscosity of the thick nutritional composition increases, and when administering the thick nutritional composition from a PEG catheter using the natural drop, it becomes difficult to pass through the PEG catheter. It takes a long time for this to occur, which is not desirable.

Specifically, examples of agar that can be used in the thick nutritional composition of the present invention include Ultra Agar UX-30 (Ina Foods Co., Ltd., jelly strength: 30 g/cm ² ), Ultra Agar UX-100 (Ina Shokuhin Kogyo Co., Ltd., Jelly strength: 100g/cm ² ), Ultra Agar AX-30, Ina Foods Kogyo Co., Ltd., Jelly strength: 30g/cm ² ), Ultra Agar AX-100, Ina Foods Kogyo Co., Ltd., Jelly strength: 100g/cm ² ), Ultra Agar BX-30, Ina Foods Co., Ltd., jelly strength: 30g/cm ² ), Ultra Agar BX-100, Ina Foods Co., Ltd., jelly strength: 100g/cm ² ), etc. It will be done.

The raw materials for pectin that can be used in the thick nutritional composition of the present invention are widely found in plant tissues, but are mainly derived from the peel of citrus fruits such as limes, lemons, and oranges, apple pomace, and beet pulp. The extracted material can be used. Moreover, what is normally commercially available can also be used.
The pectin that can be used in the thick nutritional composition of the present invention preferably has a high methoxyl pectin with a degree of esterification of 50 to 75%, preferably 68 to 75%. Low methoxyl pectin with a degree of esterification lower than 50% is not preferred because the thick nutritional composition will gel.

The amount of pectin that can be used in the thick nutritional composition of the present invention is preferably 0.45 to 0.60% by mass, preferably 0.50 to 0.60% by mass based on the total amount of the thick nutritional composition. It is 0.55% by mass. If the amount of pectin is less than 0.45% by mass, the solid content of the thick nutritional composition will not be dispersed but will precipitate, which may cause occlusion of the PEG catheter, which is not preferable. When the amount of pectin added exceeds 0.60% by mass, the viscosity of the thick nutritional composition increases, and when administering the thick nutritional composition from a PEG catheter using the natural fall, it is difficult to pass through the PEG catheter. It takes a long time for this to occur, which is not desirable.

Specifically, as a specific pectin that can be used in the thick nutrition composition of the present invention, specifically, GENU PECTIN TYPE YM -150 -LJ, GENU PECTIN TYPE YM -115 -LJ, GENU PECTIN TYPE JM -115- H-J, GENU pectin type JM-150-J, GENU pectin type JMJ-J (Taiyo Kagaku Co., Ltd.), UNIPECTINE AYD 30T, UNIPECTINE AYD 358, UNIPE CTINEAYD 380B (Unitech Foods Co., Ltd.) is mentioned.

Note that, within the scope of the gist of the thick nutritional composition of the present invention, there are no particular restrictions on the use of known dietary fibers other than agar and pectin that have been conventionally utilized in nutritional compositions. Specifically, cellulose, hemicellulose, lignin, chitin, chitosan, indigestible dextrin, polydextrose, guar gum decomposition product, psyllium seed coat, insoluble dietary fiber such as low molecular weight sodium alginate, guar gum, konjac mannan, glucomannan, alginic acid, Water-soluble dietary fibers such as chemically modified polysaccharides, polydextrose, indigestible oligosaccharides, maltitol, inulin, carrageenan, wheat bran, and indigestible dextrins (e.g., Pine Fiber C (Matsuya Kagaku Kogyo Co., Ltd.)), etc. It will be done. These dietary fibers may be used alone or in combination of two or more. These dietary fibers may be used alone or in combination of two or more.

The amount of dietary fiber that can be used in the thick nutritional composition of the present invention can be adjusted as appropriate depending on the subject to whom it is applied.
As the lipid to be added to the thick nutritional composition of the present invention, any of various known lipids that have been conventionally used in nutritional compositions can be used. Linseed oil, perilla oil, olive oil, sesame oil, rice bran oil, safflower oil, perilla oil, soybean oil, corn oil, rapeseed oil, germ oil, perilla oil, palm kernel oil, sunflower oil, cottonseed oil, coconut oil, peanut oil Examples include vegetable oils and fats such as fish oil, animal oils and fats such as milk fat, medium chain fatty acids, and highly unsaturated fatty acids. These may be used alone or in combination of two or more. In addition, processing agents such as DHA, EPA, and diacylglycerol can also be added.

The amount of lipid in the thick nutritional composition can be adjusted as appropriate depending on the subject, but it should be 1.0 to 8.0 g/100 kcal (0.08 to 0.79 kcal) based on the total amount of the thick nutritional composition. /g) is preferable.

Vitamins may be added to the thick nutritional composition of the present invention. Examples of vitamins include vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, pantothenic acid, folic acid, biotin, vitamin C, vitamin A, vitamin D, vitamin E, and vitamin K, and multiple of these should be combined as much as possible. It is preferable to mix it. As vitamins, vitamin derivatives may be used.

The pH of the thick nutritional composition of the present invention can be adjusted with a pH adjuster. The pH adjuster has the function of adjusting the pH of the thick nutritional composition.
Examples of the pH adjuster include, but are not limited to, citric acid, gluconic acid, succinic acid, potassium carbonate, sodium hydrogen carbonate, carbon dioxide, lactic acid, sodium lactate, sodium citrate, adipic acid, and the like. These pH adjusters may be used alone or in combination of two or more.

The thick nutritional composition of the present invention may contain an acidulant. Acidulants have functions such as imparting sourness to nutritional compositions, preventing oxidation of foods, and adjusting pH.
As the acidulant, there are no particular limitations, but acetic acid, citric acid, succinic acid, lactic acid, malic acid, tartaric acid, gluconic acid, phosphoric acid, etc. can be used. These acidulants may be used alone or in combination of two or more.
Flavoring agents and fruit juices may also be added to the thick nutritional composition of the present invention.

The amount of the above-mentioned food additives in the thick nutritional composition can be adjusted as appropriate depending on the subject to whom it is applied.
The ingredients that may be added to the thick nutritional composition of the present invention other than the essential ingredients are not particularly limited, and may be determined as appropriate depending on the administration method, the condition of the elderly or patient to whom the thick nutritional composition is applied, etc. sell. Furthermore, for patients who require whole-body care, it is preferable to include vitamins and minerals necessary to maintain their nutritional status. It is preferable to add dietary fiber to elderly people with impaired digestive function in order to improve constipation caused by administration of the thick nutritional composition.
The thick nutritional composition of the present invention is adjusted to an appropriate viscosity using agar and pectin, and contains necessary nutritional sources in a well-balanced manner. For treatment of gastrointestinal tract function in patients with reduced swallowing and chewing ability due to myopathy, etc., patients who have difficulty taking oral intake due to consciousness disorder, postoperative patients, etc., treatment of malnutrition, prevention of reflux esophagitis. - It can be suitable for treatment and prevention and treatment of aspiration pneumonia. Administration requires long-term administration due to the risk of diarrhea and gastroesophageal reflux; however, by using the thick nutritional composition of the present invention, tasks such as hydration and additional administration of salt can be reduced, improving hygiene. It is expected that it will be extremely useful in improving the quality of life of patients and increasing work efficiency in nursing care and nursing care settings. .
Examples of raw materials and their blending amounts that may be incorporated into the thick nutritional composition of the present invention are shown in the table below. In addition to the ingredients in the table below, soy protein, carnitine, DHA, EPA, vitamins, sweeteners, flavorings, etc. may also be blended.

The thick nutritional composition of the present invention can be produced by a known method. For example, it can be produced by adding nutrients, agar, pectin, and other necessary ingredients to heated water and stirring. Alternatively, prepare a solution of agar dissolved in warmed water and a solution of pectin dissolved in water, add nutrients and other desired ingredients to either, and mix and stir the two solutions. It can be manufactured in

The obtained thick nutritional composition can be manufactured into a product by, for example, being continuously sterilized and then filled into a container. The continuous sterilization method includes, but is not limited to, ultra-high temperature short-time (UHT) sterilization, hot water sterilization, batch sterilization, and combinations thereof. The sterilization is preferably carried out in a short period of time. By performing sterilization in a short period of time, deterioration of the components contained in the thick nutritional composition can be suppressed.

The container to be filled with the thick nutritional composition is not particularly limited, and any known container may be used. Examples of such containers include Tetra Pak (registered trademark), cart cans, glass containers, metal cans, aluminum pouches, plastic containers, and the like. Among these, it is preferable to use a plastic container.

The raw materials for the plastic container include polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polyvinyl acetate (PVAc), polycarbonate (PC), polybutylene terephthalate (PBT), polyethylene terephthalate (PET), It is preferable to use polyethylene naphthalate (PEN), ethylene-vinyl acetate copolymer (EVA), ethylene-α-olefin copolymer, polyfluorocarbon, polyimide, and the like.

The plastic container further includes polyethylene terephthalate (PET), polyethylene naphthalate (PEN), ethylene-vinyl alcohol copolymer (EVOH), polyvinylidene chloride (PVDC), polyacrylonitrile, polyvinyl alcohol, polyamide, polyester, etc. Gas barrier resin layer: Gas barrier inorganic layers such as aluminum foil, aluminum vapor deposited film, silicon oxide film, and aluminum oxide film may be used in appropriate combination. By providing the gas barrier layer, deterioration of the thick nutritional composition due to oxygen, water vapor, etc. can be prevented.

Furthermore, the container may be further shielded from light. By blocking light, for example, deterioration of vitamin A, vitamin B2, vitamin C, vitamin K, etc. that may be included in the thick nutritional composition due to light can be suppressed.

The containers mentioned above may be commercially available, such as soft pouches (Fuji Seal Co., Ltd.), bottled pouches (Toppan Printing Co., Ltd.), spouches (Dainippon Printing Co., Ltd.), and cheer packs (Hosokawa Yoko Co., Ltd.). etc. can be used.

The present invention will be specifically described below with reference to Examples, but the present invention is not limited thereto. In the examples, "parts" or "%" are used, but unless otherwise specified, "parts by mass" or "% by mass" are expressed.

(Example 1)
The preparation method for preparing 4000g is described below. The blending amount of each raw material is as shown in Table 1. 1500 g of blended water was weighed into a 5 L stainless steel beaker and heated to 80° C. or higher in a hot water bath. Next, agar with a jelly strength of 30 g/cm ² (Ultra Agar UX-30, Ina Food Industry Co., Ltd.) and pectin with an esterification degree of 70 (GENU Pectin JM-150-J, Sansho Co., Ltd.) were added and dissolved thoroughly. After cooling, whey protein (WPC392, Fonterra) and slowly digestible dextrin (HBD-20, Matsutani Chemical Industry Co., Ltd.), which is a carbohydrate, were added. A dispersion in which vegetable oil as a lipid and glycerin fatty acid ester as an emulsifier were mixed at 70° C. was mixed into the solution.

In addition, as minerals, purified salt, sodium dihydrogen phosphate (crystal), calcium gluconate, magnesium chloride, tripotassium citrate, potassium chloride, soybean dietary fiber as dietary fiber, citric acid, malic acid, lactic acid ( 50% liquid) and sodium lactate (50% liquid) were added as appropriate and stirred. Water was added until the total amount was 4000 g, and the mixture was dissolved and dispersed until a uniform state was obtained. The obtained solution was homogenized and continuously sterilized, and after filling into aluminum pouches with spouts so that each pouch weighed 500 g, the containers were sterilized at 90° C. for 10 minutes. After the container sterilization treatment, the container was cooled to produce a thick nutritional composition containing 0.06% by mass of agar and 0.5% by mass of pectin.

The properties of the obtained thick nutritional composition were observed, and the values of various components were calculated and the physical properties were evaluated. The method is as follows.
(1) Calories were calculated as (4kcal×carbohydrate content)+(9kcal×lipid content)+(4kcal×protein content)+(2kcal×dietary fiber content) and expressed as kcal.
(2) pH: After the thick nutritional composition was allowed to stand at 25° C. for 24 hours, the pH was measured using a pH meter METTLER TOLEDO MP220 (METTLER TOLEDO).
(3) Viscosity: After leaving the thick nutritional composition at 25°C for 24 hours, measure using a B-type rotational viscometer (manufacturer: BROOKFIELD, model: DV-II+Pro, measurement conditions: rotation speed 6 rpm, measurement time 1 minute, rotor No. .63).
(4) Calorific value when using 2 to 3 bottles per day: Calculated from the amount of heat per bottle.
○: Within the appropriate range (900 to 1100 kcal/day) when using 2 bottles per day, or within the appropriate range (1300 to 1700 kcal/day) when using 3 bottles per day.
×: Outside the appropriate range (900-1100 kcal/day) when using 2 bottles a day, or outside the appropriate range (1300-1700 kcal/day) when using 3 bottles a day.

The calorific value per bottle of the obtained thick nutritional composition was 499 kcal, the concentration (calorific value/g) was 1.0 kcal/g, the pH was 3.88, and the viscosity was 2,200 mPa・s. there were. The calorific value per two bottles is 998 kcal, and the calorific value per three bottles is 1,497 kcal, which is within the appropriate range when using two bottles per day and within the appropriate range when using three bottles per day. Ta. The results are shown in Table 2.

(Example 2)
Example 1 except that the amount of slowly digestible dextrin, which is a carbohydrate, was changed to 9.0% by mass, and the amount of fat (vegetable oil), which is a lipid, was changed to 3.5% by mass. Exactly the same preparation method was repeated to obtain a thick nutritional composition. The calorific value per bottle of the obtained thick nutritional composition was 451 kcal, the concentration was 0.9 kcal/g, the pH was 3.95, and the viscosity was 1,800 mPa·s. The calorific value per two bottles is 902 kcal, and the calorific value per three bottles is 1,353 kcal, which is within the appropriate range when using two bottles per day and within the appropriate range when using three bottles per day. Ta. The results are shown in Table 2.

(Example 3)
A thick nutritional composition was obtained by repeating the same preparation method as in Example 1, except that the amount of slowly digestible dextrin, which is a carbohydrate, was changed to 17.3% by mass. The calorific value per bottle of the obtained thick nutritional composition was 549 kcal, the concentration was 1.1 kcal/g, the pH was 3.80, and the viscosity was 3,800 mPa·s. The calorific value per two bottles is 1,098 kcal, and the calorific value per three bottles is 1,647 kcal, which is within the appropriate range when using two bottles per day and within the appropriate range when using three bottles per day. Met. The results are shown in Table 2.

(Example 4)
Example 1 was exactly the same as Example 1, except that the amount of slowly digestible dextrin, which is a carbohydrate, was changed to 17.4% by mass, and the amount of whey protein (WPC392), which was a protein, was changed to 2.7% by mass. The preparation method was repeated to obtain a thick nutritional composition. The calorific value per bottle of the obtained thick nutritional composition was 505 kcal, the concentration was 1.0 kcal/g, the pH was 3.99, and the viscosity was 1,100 mPa·s. The calorific value per two bottles is 1,010 kcal, and the calorific value per three bottles is 1,515 kcal, which is within the appropriate range when using two bottles per day and within the appropriate range when using three bottles per day. Met. The results are shown in Table 2.

(Comparative example 1)
A thick nutritional composition was obtained by repeating the same preparation method as in Example 1, except that the amount of slowly digestible dextrin, which is a carbohydrate, was changed to 10.0% by mass. The calorific value per bottle of the obtained thick nutritional composition was 403 kcal, the concentration was 0.8 kcal/g, the pH was 4.01, and the viscosity was 1,700 mPa·s. The calorific value per two bottles is 806 kcal, and the calorific value per three bottles is 1,209 kcal, which is outside the appropriate range when using two bottles per day and outside the appropriate range when using three bottles per day. Ta. The results are shown in Table 2.
In addition, one bottle of the thick nutritional composition of Example 1 or 3 can be added to achieve the appropriate range, although it requires effort and time for management.

(Comparative example 2)
A thick nutritional composition was obtained by repeating the same preparation method as in Example 1, except that the amount of slowly digestible dextrin, which is a carbohydrate, was changed to 20.0% by mass. The calorific value per bottle of the obtained thick nutritional composition was 604 kcal, the concentration was 1.2 kcal/g, the pH was 3.77, and the viscosity was 4,200 mPa·s. The calorific value per two bottles is 1,208 kcal, and the calorific value per three bottles is 1,812 kcal, which is outside the appropriate range when using two bottles per day and outside the appropriate range when using three bottles per day. Met. The results are shown in Table 2.
In addition, one bottle can be used to replace the thick nutritional composition of Example 1 or 2, although it takes time and effort to manage in order to maintain the appropriate range.

(Comparative example 3)
A thick nutritional composition was obtained by repeating the same preparation method as in Example 1, except that the amount of filling into the aluminum pouch with a spout was changed to 300 g per pouch. The calorific value per one bottle of the obtained thick nutritional composition is 299 kcal, the calorific value per two bottles is 599 kcal, and the calorific value per three bottles is 898 kcal, which is an appropriate range when using two bottles per day. It was also outside the appropriate range when using 3 bottles per day. The results are shown in Table 2.
In addition, one bottle can be used to replace the thick nutritional composition of Examples 1, 2, or 3, although it takes time and effort to manage it in order to keep it in an appropriate range.

All publications, patents, and patent applications cited herein are incorporated by reference in their entirety.

In a thick nutritional composition containing nutrients including proteins, lipids, and carbohydrates, the concentration of the thick nutritional composition is 0.9 to 1.1 kcal/g, and the calorific value per bottle is 450 to 550 kcal/g. By making it into a book, patients undergoing rehabilitation or long-term treatment can easily use two or three bottles of the thick nutritional composition per day.

Claims

A thick nutritional composition containing nutrients including proteins, lipids, and carbohydrates, the concentration of the thick nutritional composition is 0.9 to 1.1 kcal/g, and the calorific value per bottle is 450. A thick nutritional composition containing ~550 kcal/piece and used 2 to 3 bottles per person per day.
The thick nutritional composition according to claim 1, which has a pH of 3.0 to 4.5.
The thick nutritional composition according to claim 1 or 2, which contains slowly digestible dextrin in an amount of 10.0 to 17.2 g/100 kcal.
The thick nutritional composition according to any one of claims 1 to 3, which has a viscosity of 1,000 to 4,000 mPa·s at 25°C.
The thick nutritional composition according to any one of claims 1 to 4, wherein the amount of protein blended is 2.7 to 5.5 g/100 kcal.
A thick nutritional composition containing nutrients including proteins, lipids, and carbohydrates, the concentration of the thick nutritional composition is 0.9 to 1.1 kcal/g, and the calorific value per bottle is 450. A thick nutritional composition with ~550kcal/piece.
A nutritional composition containing nutrients including proteins, lipids, and carbohydrates and used 2 to 3 bottles per person per day, the concentration of at least one of the nutritional compositions being 0.9 to 1.1 kcal/ g, and the calorific value per bottle is 450 to 550 kcal/piece.