TWI565418B - Semi - solid nutrition for gastric stoma - Google Patents

Description

Semi-solid nutrient for gastric stoma

The present invention relates to a semi-solid nutrient for a gastrostomy.

Since the esophagus is in contact with the trachea, the laryngeal cap blocks the throat of the entrance of the trachea through swallowing to prevent swallowing. When a normal person is swallowing, the coughing or coughing causes the accidental food to be discharged from the trachea. Even if the bacteria in the food enter the trachea or the lungs due to a swallowing, the bacteria can be expelled due to immunity. There is almost no impact on general social life.

However, those who have reduced the swallowing function due to the influence of diseases such as the brain and the like, and cannot swallow the food smoothly, and because the activity of the laryngeal cap is lowered, the coughing or coughing action is slow and easy to swallow. Further, the bacteria in the food enter the trachea or the lungs due to a swallowing, and thus, the bacteria cannot be expelled due to a decrease in immunity, and thus there is a problem that bacterial pneumonia is easily infected. This problem is applied to a patient who has difficulty in oral intake of food, and a percutaneous endoscope that is injected into the stomach of the patient through a nutrient tube inserted through the abdominal wall of the patient and the stomach opening of the stomach wall. In the Percutaneous Endoscopic Gastrostomy, the bacteria in the food enter the trachea or the lungs due to the reflux of the gastroesophageal tract.

Usually, the gastroesophageal reflux refers to the function of the sphincter which prevents the reflux of gastric juice, the decrease of the sphincter of the esophagus and the stomach, the increase of the abdominal pressure, the increase of the secretion of the gastric juice, and the intake of excessive food. The current situation, there is no fundamental treatment for gastroesophageal reflux The law is based on symptomatic therapy. Furthermore, if the elderly are unable to get oral intake due to the effects of cerebrovascular disorders, etc., the immunity is also significantly reduced. If the contents of the stomach reach the lungs due to the reflux of the gastroesophageal tract, severe pneumonia will occur, the most serious. The situation may be caused by respiratory failure. For example, it has been reported in Non-Patent Document 1 that 10% to 20% of patients with gastrostomy are high risk group patients with gastroesophageal reflux.

Therefore, the so-called semi-solid nutrient for gastric ostomy used in the PEG method is not only a function as a nutrient, but also a decrease in gastroesophageal reflux is one of important subjects from the viewpoint of improving the safety of gastrostomy nutrition. As a technique for solving this problem, Patent Document 1 and Patent Document 2 can be cited.

Patent Document 1 discloses a semi-solid enteric nutrient having a form-retaining property, specifically, adding a seaweed to a liquid nutrient for semi-solidification, or imparting form retention by solidifying an egg. Sexual enteral nutrition can be used to prevent gastroesophageal reflux. In the process of injecting the semi-solidified nutrient into the stomach through the gastrostomy tube, the nutrient is broken, but the broken nutrient also has a form retention in the stomach, thereby stimulating the peristalsis of the stomach, and the result can be It is considered to prevent the reflux of the gastroesophage.

In the production stage of the nutritional composition, the manufacturing technique of the semi-solidified colloidal nutrient is disclosed in Patent Document 2, and is similar to Patent Document 1, and provides a semi-solid shape which imparts form retention to a seaweed. Nutritional composition.

On the other hand, in the study shown in Non-Patent Document 2, it is shown that the nutrient composition which can be used for preventing the reflux of the gastroesophage is not necessarily limited to a substance having a form retention property like a solid. That is, the system records 10000mPa. s The above-mentioned (containing 10000 mPa·s) high-viscosity semi-solid composition is injected from the gastrostomy tube in a short time of about 10 minutes or more in an amount of about 200 g or more (including 200 g), thereby giving the stomach wall The flaccid effect is caused, and as a result, a strong gastric peristalsis is caused from the esophageal side toward the small intestine side through the stretching sensor existing in the stomach wall, thereby suppressing the backflow of the stomach contents.

[Previous Technical Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open Publication No. 2007-211032

[Patent Document 2] Japanese Patent Laid-Open Publication No. 2006-182767

[Non-patent literature]

[Non-Patent Document 1] Coben RM: Gastroenterogy 1994

[Non-Patent Document 2] "Manipulation of the semi-solid short-time injection method from the stomach stoma and its shape" Hiroshi Hiroshi prepares a semi-solid short-time ingestion method from the stomach stoma - the goal is to improve the QOL dental medicine for patients with gastrostomy Published on pages 19-26 (2006)

In recent years, the semi-solid shape nutrient composition can inhibit the gastroesophageal reflux of patients with gastrostomy. It is obvious that the nutrient composition will be digested and absorbed according to the properties of the semi-solid shape composition. Brought adverse effects. That is, the nutrient composition injected into the stomach as a bolus remains in the stomach and mixed with gastric acid, derived from a colloidal semi-solid composition. The food group is directly delivered to the small intestine in this form. In order to make the commercially available semi-solidifying agent semi-solidified, the colloidizing agent is originally a substance that is difficult to digest. Therefore, the bolus is directly excreted due to insufficient digestion, and the utilization of nutrients in the body is lowered and there is a cause of the patient. The state leads to malnutrition. Therefore, the enteral nutrient which imparts form retention in Patent Document 1 and the colloidal nutrient which is patent document 2 have a problem of causing malnutrition even if the reflux of the stomach contents can be suppressed. Therefore, in addition to preventing gastroesophageal reflux, it also seeks digestion. A good semi-solid liquid food with good absorption.

The second point is that in addition to nutrients, safety in moisture management is also an important issue. The semi-solid shape composition for the purpose of replenishing water is commercially available, but the individual purchase of the nutrient composition has an economic burden, so in most cases, it will be called a thickening agent. The powder tackifier is dissolved in tea or the like and injected from the gastrostomy tube, but it takes a lot of effort to dissolve the thickener cleanly. The third point is that most of the side effects recognized by patients with gastrostomy are problems such as diarrhea and constipation. In recent years, it has been clarified that the maintenance of the large intestine function is important for dietary fiber, and an appropriate prescription for dietary fiber is also sought in the semi-solid nutritional composition.

Here, in one aspect of the present invention, there is provided a nutrient which can suppress and prevent reflux of the gastroesophage, and is excellent in decomposability of a bolus in the intestine. In another aspect of the present invention, there is provided a semi-solid composition which maintains the physical properties of a semi-solid composition and increases the moisture content, thereby providing a nutrient which can suppress and prevent reflux of the gastroesophage during water replenishment. In other forms of the invention, a nutrient is provided which has suitable types and amounts of dietary fiber and is therefore useful for the maintenance of large intestine functions.

The present inventors have intensively studied in view of the problems of the above-mentioned prior art, and found that a semi-solid nutrient for gastric ostomy containing 7 to 17% by mass of saccharide and 1.5 to 6.5% by mass of protein, which is at 37 ° C The artificial intestinal juice was stirred at 65 rpm for 60 minutes, and the residual ratio indicated by the residue ratio calculated by the shape change evaluation test of the weight of the residue by a sieve having a pore size of 300 μm was 20% or less (including 20%). And solve the above problems.

According to the present invention, it is possible to suppress and prevent frequent gastroesophageal reflux in patients with gastrostomy.

According to the present invention, a semi-solid nutrient for a stomach ostomy can be provided, which is a state in which a sufficient amount of nutrients, moisture, and dietary fiber can be easily digested even in elderly patients who are entangled in the gastrointestinal tract. Safely replenish.

[To implement the type of invention]

The first form of the present invention is a semi-solid nutrient for gastrostomy, comprising 7 to 17% by mass of saccharide and 1.5 to 6.5% by mass of protein, which is rotated at 65 rpm in artificial intestinal juice at 37 °C. After stirring for 60 minutes, the residual ratio of the bolus represented by the above-mentioned residue ratio calculated by the shape change evaluation test of the weight of the residue by a mesh sieve having a pore size of 300 μm was 20% or less. (including 20%).

Thereby, it is possible to provide a nutrient which is excellent in the decomposition of the stomach and esophagus and which is excellent in the decomposition of the bolus in the intestine.

In the present specification, "the residue ratio is calculated by a shape change evaluation test for measuring the weight of the residue by a mesh sieve having a diameter of 300 μm after being stirred at 65 ° C for 60 minutes in an artificial intestinal juice at 37 ° C. The residual rate of the bolus is determined by adding a semi-solid nutrient for gastrostomy and stirring at 65 ° C for 60 minutes in an artificial intestinal juice at 37 ° C, and then passing through a mesh sieve to evaluate the shape change of the weight of the residue. In the test, the ratio (%) of the above-mentioned residue weight of the above-mentioned semi-solid nutrient for gastric stoma in the artificial intestinal juice is specifically 500 ml of artificial intestinal juice (pH 6.8; manufactured by Kanto Chemical Co., Ltd.). The mixture was fed into a beaker of a paddle dissolving tester (manufactured by Toyama Industries Co., Ltd.), and heated at 37 ° C for 30 minutes. In this solution, 100 g of a semi-solid nutrient for the gastrostomy as a sample was injected as a syringe, and then, After the sample was contacted with the paddle of the dissolution tester, the rotation tester was stopped at a speed of 65 rpm for 60 minutes, and the solution together with the sample dispersed in the liquid was passed through a sieve of 60 meshes ( Aperture 300μm The JIS standard is TEST-SIEVE), and the solid content remaining on the mesh is used as a residue, and the weight is measured. The weight of the residual weight (g) is calculated as the weight of the first semi-solid nutrient for the gastric stoma. Residual rate of the group (%).

In the following examples, 500 ml of artificial gastric juice (pH 1.2; manufactured by Kanto Chemical Co., Ltd.) was fed to a beaker of a dissolution tester (manufactured by Toyama Industrial Co., Ltd.) in the case of measuring the residual rate (%) of the eggplant relative to the artificial gastric juice. Medium and added at 37 ° C At a temperature of 30 minutes, 100 g of the sample was injected into the solution as a syringe. The paddle of the dissolution tester was rotated at a speed of 3 revolutions per minute for 5 minutes without contacting the sample, and the dissolution tester was stopped, and the solution together with the sample dispersed in the liquid was passed through a sieve of 60 meshes. The solid fraction on the mesh was used as a residue and its weight was measured. The residue percentage (%) of the bolus is the ratio (%) of the residue weight (g) calculated from the injection amount of 100 g.

Moreover, the mesh screen refers to the number of standard mesh screens specified by JIS, and the 60 mesh holes refer to mesh screens having a pore size of 300 μm.

The semi-solid nutrient for gastric stoma of the present invention has a residual rate of 20% or less (including 20%) in the artificial intestinal juice, preferably 10% or less (including 10%), but in the artificial gastric juice, the oar is used. The residual rate of the bolus after stirring at a low speed of 3 rpm for 5 minutes is preferably 80% or more (including 80%), more preferably 85% or more (including 85%).

In the present invention, after the semi-solid nutrient for the gastrostomy is injected, it is confirmed that 80% or more (including 80%) of the stomach remains as required for the stomach to start squirming. However, the residual rate of the group of the artificial gastric juice after 60 minutes was the same as that of the artificial intestinal juice, and it was confirmed that it was reduced to 10% or less (including 10%).

The reason for this is that the semi-solid nutrient for gastric stoma of the present invention is a paste, but after the gastrostomy tube is injected, the shape of the bolus is maintained in the stomach to bring relaxation to the stomach wall, and the stimulation is stretched. The sensor, and injected in about 5 minutes, triggers strong gastric peristalsis. The viscosity in the B-type rotary viscometer is 10000 mPa. When s or more (including 10000 mPa.s), the residual rate of the group after stirring at 3 rpm for 5 minutes is 80% or more (including 80%), and a sufficient shape of the pellet is maintained at the start of peristalsis.

The semi-solid nutrient for gastric ostomy of the present invention is preferably a water- and/or dietary fiber other than saccharide and protein, and the semi-solid nutrient for gastric ostomy of the present invention is saccharide, protein, and moisture. And a thickening component as an essential component, and it is more preferable to further contain a dietary fiber in the semi-solid nutrient for the gastrostomy as needed.

Further, the semi-solid nutrient for gastricostomy may further contain, as an optional component, a selected from the group consisting of lipids, minerals, vitamins, amino acids, peptides, dietary fibers, acidulants, emulsifiers, additives, and perfumes. At least one of the groups.

The moisture content of the semi-solid nutrient for gastrostomy of the present invention is preferably from 91 to 177 ml of water/100 Kcal, and the amount of water is more preferably from 112 to 144 ml of water per 100 Kcal.

As described above, from the viewpoint of improving the safety of the stomach ostomy nutrition, it is required from the clinical site to suppress/prevent the gastroesophageal reflux during the water replenishment. For the current patient's water replenishment system, the following methods are carried out: (a) injecting a replenishing liquid with a gastrostomy at a time when the chance of reflux of the gastroesophageal tract is considered to be less; (b) adding a thickener to the hospital to A semi-solid shaped thick paste is added to replenish moisture; (c) a tackifier or a colloidizing agent is added in advance to form a semi-solid shape to replenish moisture. However, in patients with frequent epigastric reflux, it is impossible to avoid the chance of seizure during the inter-day period. It is more troublesome to use thickeners in the in-hospital adjustment, and there is a medical economical purchase of commercially available semi-solid water replenishment foods. problem. However, in the semi-solid nutrient for gastricostomy of the present invention, since the gastrostomy patient can contain the required amount of water, the gastroesophageal reflux in the water supply can be suppressed/prevented. Due to the low concentration of calories as a nutrient for the composition As the solid concentration is low, the viscosity is also lowered. Therefore, by adjusting the amount of the viscosity-increasing component, a suitable viscosity and a semi-solid nutritional composition having a residual rate of the bolus can be prepared. The amount of water required for admission to a patient is, for example, according to the guidelines for feeding management. The weight of a person over 25 years old (including 25 years old) and under 55 years old is 35ml per kilogram, 55 years old or older (including 55 years old) and not The weight of a person over 65 years old needs 30ml per kilogram, and the weight of a person over 65 years old (including 55 years old) needs 25ml per kilogram. When taking a semi-solid nutrient for gastrostomy, it can also be used together. Take the amount of water needed for a day.

Further, the moisture content of 91 to 177 ml of water/100 Kcal means that the amount of heat of the semi-solid nutrient for the gastrostomy of the present invention is 91 to 177 ml per 100 Kcal, which is contained in the semi-solid nutrient for gastrostomy.

The semi-solid nutrient for gastrostomy of the present invention is preferably from 0.5 to 0.9 Kcal/g per 1 g of heat, more preferably from 112 to 144 Kcal/g.

Usually, a nutritionally managed bedridden patient with a daily dose of about 1000 Kcal, if the caloric concentration of the nutrient composition is set to about 0.5 to 0.9 Kcal/g, can supply the necessary energy and the necessary amount of water at the same time.

The semi-solid nutrient for gastric stoma of the present invention has a viscosity of 10,000 to 40,000 mPa. s is better, from 15000 to 305000 mPa. s is better, with 20,000 to 25,000 mPa. s is even better. Meanwhile, the viscosity range refers to a viscosity range measured when the article temperature is 25 ° C, and the viscosity is measured at a rotation speed of 6 rpm (No. 64 rotor) using a B-type viscometer used in the examples described later.

As described above, in order to induce the receptive relaxation of the stomach as one of the factors of gastroesophageal reflux, it is not necessary to form a shape retention of solidification, such as injection of 10000 mPa. Highly viscous above s (including 10000mPa.s) The semi-solid shape composition produces flaccidity, which causes intense gastric peristalsis within a few minutes after injection. Therefore, the viscosity is between 10,000 and 40,000 mPa. In the range of s, strong gastric peristalsis is triggered within a few minutes after injection.

The pH of the semi-solid nutrient for gastric mucosa of the present invention is preferably 3.0 or more (including 3.0) 4.0 or less (including 4.0).

When the pH is pH 3.0 or more (including 3.0) 4.0 or less (including 4.0), it has a moderate acidity, and is preferable from the viewpoint of flavor, and can prevent gastric tube obstruction caused by coagulation of protein due to contact with gastric acid. The problem. Moreover, since it is an acidic pH, the growth of the bacteria in the tube can be prevented.

The semi-solid nutrient for gastric stoma of the present invention is preferably one containing dietary fiber. This can be used to maintain the function of the large intestine. Dietary fiber has been formulated in liquid foods for the purpose of preventing diarrhea in the past. However, in the short-time injection method of semi-solid nutrient composition, in order to promote the movement of the digestive tract, the squat caused by the administration of the tube can be reliably suppressed. This view does not necessarily require the blending of dietary fiber. However, the use of short-chain fatty acids produced by the anabolism of intestinal bacteria by fermented dietary fiber has been confirmed to be useful for the maintenance of the function of the large intestine, so that the proper function of the dietary fiber can maintain the function of the large intestine.

Therefore, the content of the dietary fiber in the semi-solid nutrient for gastrostomy of the present invention can be appropriately adjusted depending on the subject, but the total amount of the semi-solid nutrient for the gastrostomy is 0.2 to 1.4. The mass% is preferably, and the ratio is preferably 0.5 to 1.1% by mass.

Further, the dietary fiber is roughly classified into a fermented dietary fiber fermented by anaerobic bacteria existing in a human large intestine, a non-fermentable dietary fiber which is not fermented, and a non-fermentable food of the present invention. Examples of the fiber include low molecular weight sodium alginate, polydextrose, amaranth, three scented gum, psyllium seed coat, weaving vitamins, and gellan gum. Further, the fermented dietary fiber of the present invention may, for example, be pectin, low molecular weight pectin, guar gum, guar gum decomposition product, guar gum hydrolyzate, low molecular weight guar gum, sugar beet fiber, and indigestible. Desserts, gum arabic, pullulan, tamarind gum, water-soluble soy dietary fiber (WSSF), etc., preferably guar gum decomposition products.

The dietary fiber used in the semi-solid nutrient for gastrostomy of the present invention may be a fermented dietary fiber or a non-fermentable dietary fiber alone, or a mixture of two dietary fibers may be used.

In addition, the classification of fermentability and non-fermentability is based on the energy conversion factor of Food Newborn No. 021702, and the energy conversion factor (kcal/g) is 0 kcal/g. Non-fermentable, 1 or 2 The kcal/g is fermentative.

Moreover, the fermented dietary fiber and the non-fermentable dietary fiber are preferably in a ratio of a mass ratio of 1:1.5 to 1:0.67, and the fermented dietary fiber and the non-fermentable dietary fiber are 1:1.2 to A ratio of 1:0.8 mass ratio is better.

When the fermented dietary fiber and the non-fermentable dietary fiber are in a ratio of 1:1.5 to 1:0.67, it is preferable from the viewpoint of the safety of the stomach ostomy nutrition.

As described above, the semi-solid nutrient for gastric ostomy of the present invention comprises: a nutrient essential to the saccharides and proteins of the above components, and a dietary fiber as needed.

The saccharide of the present invention is an energy source that is absorbed by a living body, that is, However, it is not particularly limited, and examples thereof include monosaccharides, disaccharides, and polysaccharides. Specific examples of the monosaccharide include glucose, fructose, and galactose. Specific examples of the disaccharide include sucrose, lactose, maltose, isomaltose, and trehalose. Specific examples of the polysaccharide include starch (amylose, amylopectin), processed starch (modified Starch), white granulated sugar, tri- warm sugar, fine granulated sugar, dextrin, and the like. Among these, it is preferred to use dextrin, processed starch, and white granulated sugar.

The dextrin coefficient is a general term for a substance in which α-glucose is polymerized by a glycosidic bond, and can be obtained by hydrolyzing starch. In the dextrins, the decomposition rate in the small intestine is slowed down and the absorption is slow, so that the blood sugar can be prevented from rising sharply. Further, by using dextrin, the osmotic pressure of the semi-solid nutrient for the gastrostomy can be reduced, and the osmotic pressure can be prevented. The dextrin may be any one of high-polymerity polymer dextrin of α-glucose and low molecular weight dextrin dextrin of α-glucose, but it is preferable to use a polymer dextrin which can lower the osmotic pressure. . In addition, low molecular ablextatin, also known as maltodextrin, is generally a polymer of 3 to 5 alpha-glucose.

The dextrin can be prepared by itself or by a commercially available person. In the preparation of dextrin, conventional starch, for example: corn, waxy corn, wheat, rice, waxy rice, waxy milo, beans (broad beans, mung beans, small red beans) The starch contained in the potato, sweet potato, cassava, etc. can be prepared by hydrolysis in a conventional manner. In addition, commercially available dextrin can be applied, for example, to TK-16 (manufactured by Matsutani Chemical Industry Co., Ltd.). These saccharides may be used singly or in combination of two or more.

The white sugar refers to a sugar containing a main component of 97.8 to 98.00%, and There is a crystallized polysaccharide of about 1% of water and invert sugar (mixture of glucose and fructose).

The processed starch is subjected to physical, enzymatic or chemical treatment in starch. In the case of performing this treatment, physical properties such as solubility in water, gelatinization temperature, viscosity stability upon heating and dissolution, physical stability, and the like may vary.

The physical treatment may be, for example, a wet heat treatment, a high-frequency treatment, a radiation treatment, a bleaching treatment, an acid treatment, an alkali treatment, or the like. Examples of the enzyme treatment include enzyme treatments such as α-amylase, β-amylase, glucoamylase 7, isoamylase, and pullulanase. Examples of the above chemical treatment include oxidation treatment, esterification treatment, acetonitrile treatment, etherification treatment, and crosslinking treatment.

The processed starch obtained by the above treatment is not particularly limited, and examples thereof include calcined dextrin, acid-treated starch, alkali-treated starch, bleached starch, enzyme-treated starch, sodium starch glycolate (Sodium Starch Glycolate), and sodium starch phosphate ( Sodium starch phosphate), acetylated adipic acid crosslinked starch, acetylated oxidized starch, acetylated phosphate crosslinked starch, sodium octenyl succinate starch, starch acetate, oxidized starch, hydroxypropylated phosphate Starch starch, hydroxypropyl starch, phosphoric acid crosslinked starch, phosphorylated starch, phosphoric acid monoesterified phosphoric acid crosslinked starch, and the like. Among these, it is preferred to use acetalized phosphoric acid crosslinked starch or hydroxypropylated phosphoric acid crosslinked starch.

Processed starch can be prepared by itself or commercially available. When the self-modulation is carried out, the conventional starch may be adjusted, for example, by performing at least one of the above physical treatment, enzyme treatment, and chemical treatment in the above starch. system. Commercially available products can be, for example, WMS (Ethyl acetate cross-linked starch: manufactured by Matsutani Chemical Industry Co., Ltd.), Matsutani Suisen (Ethyl phosphate cross-linked starch: manufactured by Matsutani Chemical Industry Co., Ltd.), Farinex VA70WM ( Hydroxypropylated phosphate crosslinked starch: manufactured by Matsutani Chemical Industry Co., Ltd., Farinex VA70X (hydroxypropylated phosphate crosslinked starch: manufactured by Matsutani Chemical Industry Co., Ltd.), Farinex VA70C (hydroxypropylated phosphate crosslinked starch) : manufactured by Matsutani Chemical Industry Co., Ltd.).

The processed starch may be used singly or in combination of two or more.

The saccharide content in the semi-solid nutrient for gastrostomy of the present invention can be appropriately adjusted depending on the subject to be adapted, but is 7 to 17% by mass based on the total amount of the semi-solid nutrient for the gastrostomy. Good, preferably 9 to 13% by mass.

The protein of the present invention is not particularly limited, and examples thereof include amino acids, peptides, plant proteins, and animal proteins.

The amino acid may, for example, be valine, leucine, isoleucine, lysine, methionine, phenylalanine, Essential amino acids such as threonine, tryptophan, histidine, etc.; and glycine, alanine, serine, cysteine Cysteine, asparagine, glutamine, proline, tyrosine, aspartic acid, glutamic acid Glutamic acid), a non-essential amino acid such as arginine. In addition to this, it also contains 4-hydroxyproline, 5-hydroxy lysine, γ-carboxy glutamic acid, O-Phosphoserine, O-Phosphotyrosine. Modified amines such as O-acetylserine, N ^ω -methyl arginine, Pyroglutamic acid, MN-N-formylmethionine Base acid; ornithine, citrulline, GABA, thyroxine, S-Adenosylmethionine Amino acid. Further, the above amino acids may be stereoisomers (enantiomers, differeromers), may be positional isomers (Regioisomer), or may be a mixture thereof. . Further, the amino acid may be in the form of a mineral acid salt (hydrochloride or the like), an organic acid salt (acetate or the like), or an ester body (methyl ester or the like) which can be hydrolyzed in a living body.

The peptide can be obtained by polymerizing two or more (including two) of the above amino acids by a peptide bond (melamine bond). The peptide may be a dipeptide, a tripeptide, an oligopeptide (about 10 amino acids), or a polypeptide (approximately tens to hundreds of amino acids). Further, some oligopeptides, for example, lactopeptide, casein dodecapeptide, and sardine peptide containing valyryl tyrosine, have health functions such as antihypertensive action.

Examples of the plant protein include proteins contained in rice such as rice, beans such as soybeans and tofu, and the like. Further, examples of the animal protein include proteins contained in eggs, meat, fish and shellfish, milk, and the like. Further, the soybean protein binds to bile acid and has a health function of promoting cholesterol excretion and the like.

Among these, it is preferable to use whey protein containing milk (whey) as a raw material, casein protein contained in milk, or soybean protein, and it is preferable to use whey protein. The whey protein may, for example, be a concentrated whey protein (WPC: whey protein concentrate) or a whey protein isolate. (WPI: whey protein isolate), hydrolyzed whey peptide (WPH: Whey Peptide Hydrolysate) and the like. For example, WPI18855 (manufactured by Fonterra), WPI18822 (manufactured by Fonterra), WPI1895 (manufactured by Fonterra), WPC392 (manufactured by Fonterra), WPC80 (Fonterra) can be used as examples of the commercially available ones. Made by the company), WPC7009 (manufactured by Fonterra). These proteins may be used singly or in combination of two or more.

The protein content in the semi-solid nutrient for gastrostomy of the present invention can be appropriately adjusted depending on the intended subject, but it is preferably 1.5 to 6.5% by mass, and 1.5 to 5.6% by mass based on the total amount of the nutrient. Better.

The thickening component of the essential component of the semi-solid nutrient for gastrostomy of the present invention may, for example, be agar, gelatin, pectin, guar gum, locust bean gum, glutinous polymannose, santilla gum, tamarind gum. Carrageenan, propylene glycol, carboxymethyl cellulose, gellan gum, Tara gum tamarind gum, psyllium seed gum, gum arabic, curdlan, polytriglucose (pullulan), sodium alginate, tragacanth gum, karaya gum, veegum, and the like. The semi-solid nutrient for gastrostomy of the present invention may contain a tackifying component, but it is necessary to control the viscosity in view of the following points. In other words, the above-mentioned subject "(1) the possibility of affecting the digestion/absorption of nutrients depending on the properties of the semi-solid composition) is mainly found in elderly patients with low function of the digestive organs, especially It is a case in which a liquid food solidified by a thickening component such as a seaweed is injected into a gastrostomy, and a part of the liquid food is directly excreted as a solid substance, further suggesting digestion/absorption of nutrients such as minerals. The possibility of low sexuality. Further, depending on the type of the viscosity-increasing component, the blending amount, and the liquid temperature, the properties of the semi-solid nutrient for the gastrostomy of the composition vary, and generally, a smaller amount of the tackifying component imparts only a viscosity-increasing effect. In addition, a larger amount of the tackifying component, for example, when a large amount of acacia is added, encloses the nutrient inside the solidified gel. Further, as described above, since the thickening component itself is an indigestible polysaccharide, the digestive enzyme of the human body cannot be decomposed, and even if the lower digestive tract enterobacteria are difficult to decompose, the nutrient ingested is ingested. In the case where the colloid is not sufficiently damaged, the nutrients taken from the inside of the colloid cannot be absorbed, so that the utilization efficiency of nutrients in the living body becomes low. However, when the viscosity is adjusted to a low viscosity which does not reach the amount of curing, the damage is improved and the digestion/absorption of nutrients is improved, and the gastric pacing cannot be induced, so that gastric peristalsis cannot be induced and gastroesophageal reflux is caused. The inhibition/prevention effect is impaired. In the present invention, it is achieved by adjusting the type and amount of the viscosity-increasing component of the semi-solid nutrient for gastric ostomy which is excellent in the decomposition of the granules while maintaining the high viscosity of the gastroesophageal reflux.

Therefore, the content of the viscosity-increasing component in the semi-solid nutrient for gastrostomy is preferably 0.05 to 1.5% by mass, more preferably 0.2 to 1.0% by mass, based on the total amount of the semi-solid nutrient for the gastrostomy. .

Further, the amaranth of the present invention may be a polymer having a reversing unit containing agarose and agaropectin, and most of them are derived from Gracilaria verrucosa and Asparagus ( Gracilaria gigas), Gelidium amansii, Pterocladia capillacea, Ahnfeltia plicata, etc. derived from red algae The material is not limited to the source of the raw material of the amaranth, and the form of the amaranth is in the form of a stick, a powder, a granule or the like, but is not particularly limited in the present invention.

The lipid of any component of the semi-solid nutrient for gastrostomy of the present invention is not particularly limited, and examples thereof include saturated fatty acids, unsaturated fatty acids, vegetable oils, animal fats and oils, and fish oils.

Examples of the saturated fatty acid include caprylic acid, capric acid, lauric acid, palmitic acid, and stearic acid.

Examples of the unsaturated fatty acid include oleic acid, palmitoleic acid, linoleic acid, peanut oleic acid, α-linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA: Docosahexaenoic acid). )Wait. In addition, EPA and DHA have health care functions such as an effect of suppressing an increase in blood cholesterol and an action of suppressing an increase in neutral fat.

The vegetable oil may, for example, be coconut oil, corn oil, cottonseed oil, olive oil, palm oil, palm kernel oil, peanut oil, rapeseed oil, safflower oil (safflower oil), sesame oil, soybean oil, sunflower oil, almond oil, Cashew nut oil, hazelnut oil, Australian walnut oil, mongongo oil, pecan oil, pine nut oil, pistachio oil, walnut oil, cucurbit seed oil, and Cucurbita foetidissima oil , pumpkin seed oil, watermelon seed oil, Amaranthus oil, apricot oil, apple oil, Argan oil, avocado oil, Babassu oil, moringa seed Oil), Borneo Tallow, Capesize Nut Oil, Cocoa Butter, Caroline Oil, Cohune Palm, Coriander Seed Oil, Wild Mango (Irvingia gabonensis) Oil, Flax Kernel oil, grape seed oil, hemp oil, kapok oil, Lallemantia iberica, Marula Oil, white mango seeds Oil (Meadowfoam Seed Oil), mustard oil, nutmeg butter, okra oil, papaya oil, perilla oil, brazil nut oil, pine nut oil, poppy oil (Poppy Oil), western plum Oil, quinoa oil, nigar seed oil, rice bran oil, royle oil, sacha inchi oil, camellia oil, chop oil ), tomato-seed oil, wheat oil, eucalyptus oil, sunflower oil, germ oil, coconut oil, peanut oil, and the like.

Examples of the animal fats and oils include lard, tallow, and milk fat.

The fish oil may be exemplified by fish oil such as squid, squid, squid, sardine, and saury.

Among these, it is preferred to use linoleic acid which is not synthesized in the human body, and α-linolenic acid or a lipid containing the same. These lipids may be used singly or in combination of two or more.

The lipid content in the semi-solid nutrient for gastric stoma can be appropriately adjusted according to the applicable subject, but it is preferably 0.8 to 3.5% by mass, based on the total amount of the semi-solid nutrient for the gastrostomy. It is better to 3.1% by mass.

Further, the amino acid and the oxime system of the optional components of the semi-solid nutrient for gastrostomy of the present invention are the same as those described above, and therefore will not be described here.

The mineral of any component of the semi-solid nutrient for gastrostomy of the present invention is a necessary mineral for nutrients, and examples thereof include sodium, potassium, calcium, magnesium, phosphorus, chlorine, iron, zinc, copper, and manganese. Wait. Examples of the divalent cation include calcium, magnesium, iron, zinc, copper, manganese, and the like as nutrients. The ion may be contained in the nutrient as an inorganic salt or an organic acid salt. In this case, the form to be contained may be calcium gluconate, magnesium chloride, potassium chloride, sodium chloride, sodium dihydrogen phosphate, or potassium citrate. These minerals may be used singly or in combination of two or more.

The mineral content in the semi-solid nutrient for gastrostomy can be appropriately adjusted depending on the intended subject. The preferred content of each mineral per 100 g of the semi-solid nutrient for the gastrostomy is as follows.

[mass elements]

Sodium: preferably 5 to 6000 mg, more preferably 10 to 3500 mg; potassium: preferably 1 to 3500 mg, more preferably 25 to 1800 mg; calcium: preferably 10 to 2300 mg, more preferably 30 to 300 mg; It is preferably 1 to 3500 mg, more preferably 25 to 1500 mg; magnesium: preferably 1 to 740 mg, more preferably 10 to 150 mg;

[Required trace elements]

Iron: preferably from 0.1 to 55 mg, more preferably from 1 to 10 mg; zinc: preferably from 0.1 to 30 mg, more preferably from 1 to 15 mg; copper: preferably from 0.01 to 10 mg, more preferably from 0.06 to 6 mg; It is preferably 0.1 to 3000 μg, more preferably 1 to 150 μg; manganese: preferably 0.01 to 11 mg, more preferably 0.1 to 4 mg; selenium: preferably 0.1 to 450 μg, more preferably 1 to 35 μg; 0.1 to 40 μg, more preferably 1 to 35 μg; molybdenum: preferably 0.1 to 320 μg, more preferably 1 to 25 μg; the vitamin of any component of the nutrient of the present invention may be either a water-soluble vitamin or a fat-soluble vitamin For example, the fat-soluble vitamin can be listed For example: vitamin A (retinol), vitamin D (Ergocalciferol, Cholecalciferol), vitamin E (Tocopherol, Tocotrienol), Vitamin K (phylloquinone, menaquinone), etc., such as water-soluble vitamins, such as vitamin B1 (Thiamine), vitamin B2 (Riboflavin), vitamins B3 (Niacin), Vitamin B5 (Pantothenic acid), Vitamin B6 (Pyridoxal Pyridoxamine, Pyridoxine), Vitamin B7 (Biotin ( Biotin)), vitamin B9 (folic acid), vitamin B12 (Cyanocobalamin, Hydroxocobalamin), Vitamin C (ascorbic acid), and the like. These vitamins are not limited to water-soluble vitamins or fat-soluble vitamins, and may be used singly or in combination of two or more.

The vitamin content in the semi-solid nutrient for gastrostomy can be appropriately adjusted depending on the intended subject. Generally, for fat-soluble vitamins, an amount which does not cause an Excess symptom is added, and there is no limitation on the amount of addition of the water-soluble vitamin. The preferred content of each of the vitamins per 100 g of the semi-solid nutrient for gastrostomy is as follows.

[fat-soluble vitamins]

Vitamin A: preferably 0 to 3000 μg, more preferably 20 to 200 μg; vitamin D: preferably 0.1 to 50 μg, more preferably 0.1 to 5.0 μg; vitamin E: preferably 0.2 to 800 mg, more preferably 1 to 10 mg; vitamin K: preferably from 0.5 to 1000 μg, more preferably from 2 to 50 μg;

[water soluble vitamins] Vitamin B1: preferably 0.01 to 40 mg, more preferably 0.1 to 5 mg; vitamin B2: preferably 0.01 to 20 mg, more preferably 0.05 to 5 mg; nicotinic acid (equivalent): preferably 0.1 to 300 mg NE, more preferably It is 0.5 to 30 mg of NE; pantothenic acid: preferably 0.1 to 55 mg, more preferably 0.2 to 10 mg; vitamin B6: preferably 0.01 to 60 mg, more preferably 0.1 to 10 mg; biotin: preferably 0.1 to 1000 μg, more preferably 1 to 100 μg; folic acid: preferably 1 to 1000 μg, more preferably 10 to 200 μg; vitamin B12: preferably 0.01 to 100 μg, more preferably 0.2 to 60 μg; vitamin C: preferably 1 to 2000 mg, more preferably It is 5 to 1000 mg.

The acidifying agent of any component of the semi-solid nutrient for gastrostomy of the present invention is not particularly limited, and acetic acid, citric acid, succinic acid, lactic acid, malic acid, tartaric acid, gluconic acid, phosphoric acid or the like can be used. These acidifying agents may be used singly or in combination of two or more.

The emulsifier of any component of the semi-solid nutrient for gastrostomy of the present invention is not particularly limited, and examples thereof include natural emulsifiers such as lecithin, saponin, and casein sodium; fatty acid glycerides and fatty acid sorbitan esters. , synthetic emulsifiers such as propylene glycol fatty acid esters and sucrose fatty acid esters. These emulsifiers may be used singly or in combination of two or more.

The additive of the optional component of the semi-solid nutrient for the gastrostomy of the present invention may, for example, be a pH adjusting component, a sweetener, a flavor or the like, and the content of the additive in the semi-solid nutrient for gastrostomy is appropriately adjusted.

The pH adjusting component can use citric acid, gluconic acid, succinic acid, Potassium carbonate, sodium hydrogencarbonate, carbon dioxide, lactic acid, sodium lactate, sodium citrate, and the like.

The sweetener is not particularly limited, and phenylalanine, xylitol, aspartame, sucralose, potassium sulfamate, disodium glycyrrhizinate or the like can be used.

Examples of the additive include conventional food additives such as copper gluconate, zinc gluconate, ascorbic acid 2-Glucoside, and cyclodextrin.

These pH adjusting components, sweeteners, and additives may be used singly or in combination of two or more.

The fragrance of the optional component of the semi-solid nutrient for gastrostomy of the present invention is not particularly limited, and examples thereof include acetophenone, α-amylcinnamaldehyde, anisaldehyde, and benzaldehyde. Benzyl acetate, benzyl alcohol, cinnamaldehyde, cinnamic acid, citral, citronellal, citronellol, furfural, decyl alcohol, ethyl acetate, ethyl cinnamate, Ethyl citrate, ethyl vanillin, eugenol, vanillyl alcohol, isoamyl acetate, isoamyl butyrate, isoamyl phenylacetate, dl-menthol, 1-menthol, methyl salicylate, piperonal, Propionic acid, terpineol, vanillin, d-Borneol, and the like. These fragrances may be used singly or in combination of two or more.

The semi-solid nutrient for gastricostomy of the present invention can be applied to fields such as medical treatment and food.

In the medical field, a semi-solid nutrient for gastrostomy can be used as an enteral nutrient and can be applied to enteral nutrition. Use of gastric stoma It is difficult for an elderly person or a patient who is ingested by the mouth and whose function of the intestine is normal.

The semi-solid nutrient for gastric stoma in this form contains nutrients, necessary moisture, dietary fiber, and other optional ingredients. The content of the above nutrients preferably contains an amount which satisfies the calorie, nitrogen source and the like required for the organism for the purpose of enteral nutrition. Further, the water content of the semi-solid nutrient for the gastric stoma should be set in consideration of the state of the elderly person or patient to be administered, water management, and the like.

There is no particular limitation on the addition of the components other than the essential components to the semi-solid nutrient for the gastrostomy of the present invention, and the administration method, the state of the elderly or the patient of the semi-solid nutrient for gastrostomy may be applied. And set it appropriately. For example, in the case of administration of a gastrostomy, it is preferred to add a sweetener, an acidulant, a flavor, etc. from the viewpoint of preventing discomfort during snoring. Moreover, in patients requiring systemic management, it is desirable to contain the required vitamins and minerals in order to maintain a nutritional state. In elderly people with low digestive function, etc., in order to improve constipation caused by the administration of semi-solid nutrient for gastric stoma, it is preferred to add dietary fiber.

If the semi-solid nutrient for gastrostomy of the present invention is used, it is difficult to cause gastroesophageal reflux or aspiration pneumonia. Further, the preservability and the operability of the gastrostomy tube during the administration using the gastrostomy can be improved.

Moreover, since the semi-solid nutrient for gastric stoma of this type can inhibit the occurrence of gastroesophageal reflux and can simultaneously take in water and energy, for example, by adjusting the viscosity, the use of the stomach stoma can be improved. Gastrostomy The adhesion of the tube and the digestibility of the semi-solid nutrient for the gastrostomy. Moreover, by the adjustment of the heat, the nutrition management of the elderly or the patient who is suitable for the semi-solid nutrient for the gastrostomy can be simplified. Moreover, by adjusting the pH, the preservation property and the cooling feeling can be improved. The viscosity, heat, pH, and the like can be controlled by appropriately adjusting the components in the semi-solid nutrient for gastrostomy and the content.

The semi-solid nutrient for gastrostomy of the present invention can be applied to foods. The content of the above nutrients should be appropriately selected depending on the target consumer.

There is no particular limitation on the addition of a component other than the essential component to the semi-solid nutrient for gastric stoma in this form, and it can be suitably selected according to the food to be manufactured. For example, when imparting a cooling sensation to a semi-solid nutrient for a gastric ostomy, it is preferred to add a pH adjusting component to make the pH acidic. Further, in order to obtain a specific health food, it is necessary to contain, for example, the above-mentioned dietary fiber, indigestible fructooligosaccharide, sugar alcohol, calcium citrate malate (CCM), and casein phosphopeptide (CPP: Casein phosphopeptide) and the like (health function components). Furthermore, in order to present the label of the nutritious functional food, it is necessary to make the content of the prescribed (nutritional) content of the above-mentioned vitamins, minerals, etc. within the range of the specification standard.

For example, the semi-solid nutrient for gastric stoma according to the present type can suppress the occurrence of gastroesophageal reflux, so that it can replenish suitable energy and the like, and can be a food having excellent taste.

Moreover, since the semi-solid nutrient for the gastric stoma of this type can simultaneously replenish water and nutrients, various products can be developed according to the purpose of use. For example, a semi-solid nutrient for gastrostomy having different food sensations can be produced by adjusting the amount of water. Moreover, by adjusting the heat, a semi-solid nutrient for gastric stoma can be produced in response to the need. Further, by adjusting the pH, a semi-solid nutrient for gastric stoma which imparts a desired cooling feeling can be produced.

The following is an example of a preferred method for producing a semi-solid nutrient for a gastrostomy according to the present invention.

The semi-solid nutrient for gastrostomy of this type can be produced by a conventional method, for example, by adding nutrients, acacia, and other desired ingredients in a heated water and stirring them. In addition, a solution in which warm vegetables are dissolved in water, a solution in which protein, saccharide or processed starch is dissolved in warm water, and any other desired components are added, and the two solutions are mixed and stirred. Can be manufactured.

The resulting semi-solid nutrient for gastrostomy can be completed, for example, by filling in a continuously sterilized container. The method of continuous sterilization is not particularly limited, and examples thereof include ultra-high temperature short-time (UHT) sterilization (also called instantaneous sterilization), hot water sterilization, intermittent sterilization, and the like. The above sterilization should be carried out in a short time. By sterilizing in a short period of time, deterioration of components contained in the semi-solid nutrient for gastrostomy can be suppressed.

The second form of the present invention is a semi-solid nutrient for a stomach-filling which is filled with a container-filled semi-solid nutrient for a gastrostomy of the present invention which is equivalent to 300 to 400 Kcal.

The container for filling the semi-solid nutrient for the gastrostomy is not particularly limited, and a conventional container can be used. The container can be exemplified by: Tetra Pak, paper cantocan, glass container, metal can, aluminum foil bag (aluminum) Pouch), plastic containers, etc. Among these, it is better to use a plastic container.

The raw materials of the above plastic containers are preferably polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polyvinyl acetate (PVAc), polycarbonate (PC), polybutylene terephthalate ( PBT), polyethylene naphthalate (PEN), ethylene-vinyl acetate copolymer (EVA), ethylene-α-olefin copolymer, polyfluorocarbon, and polyimine.

In the above plastic container, the following may be further used in combination: comprising polyethylene terephthalate (PET), polyethylene naphthalate (PEN), ethylene-vinyl alcohol copolymer (EVOH), poly Gas barrier resin of vinylidene chloride (PVDC), polyacrylonitrile, polyvinyl alcohol, polyamide, polyester, etc.; gas barrier inorganic of aluminum foil, aluminum vapor deposition film, cerium oxide film, aluminum oxide film, etc. Floor. By providing the gas barrier layer, deterioration of the semi-solid nutrient for gastrostomy caused by oxygen or water vapor can be prevented.

The above container may also be shielded from light. By this light shielding, for example, deterioration of light such as vitamin A, vitamin B2, vitamin C, and vitamin K contained in the semi-solid nutrient for gastrostomy can be suppressed.

The above-mentioned container can be used, for example, a soft bag (made by Fuji Seal International), a kettle bag (made by letterpress printing), and a jointed water bottle bag (Spouch; manufactured by Dainippon Printing Co., Ltd.). ; aluminum foil packaging (Cheer pack; manufactured by Hosokawa Electric Co., Ltd.).

[Examples]

Hereinafter, the present invention will be specifically described by way of examples, but the present invention is not limited thereto. In the meantime, the "parts" or "%" used in the examples means "parts by mass" or "% by mass" unless otherwise specified.

"Manufacture of semi-solid nutrient for gastric stoma"

(Example 1)

1200 parts of blended water was placed in a 5L stainless steel bucket and heated to 80 ° C or higher (including 80 ° C) in a water bath. Next, 20 parts of Ultra Agar UX30 (manufactured by Ina Food Industries Co., Ltd.) of the seaweed was added and dissolved. The obtained solution was cooled to 50 to 60 ° C, and WPI895 (Whey Protein Isolate: manufactured by Fonterra Co., Ltd.) was added with 140 parts of protein and TK-16 (dextrin: manufactured by Matsutani Chemical Industry Co., Ltd.) 400. Share. 60 parts of the vegetable oil of the lipid, 10 parts of the glycerin fatty acid ester of the emulsifier, and 35 parts of WMS (modified ethylene phosphate crosslinked starch: manufactured by Matsutani Chemical Industry Co., Ltd.) of the processed starch were mixed into the solution at 50 ° C. Mix into a dispersion. Furthermore, 0.3 parts of a water-soluble multivitamin as a vitamin, 1.5 parts of a fat-soluble multivitamin, and 20 parts of calcium gluconate, 10 parts of magnesium chloride, 3.2 parts of potassium chloride, 0.2 parts of sodium chloride, and phosphoric acid are added as a mineral. 10 parts of sodium dihydrogen and 6 parts of tripotassium citrate; 25 parts of guar hydrolysate as dietary fiber; 0.5 parts of synthetic yeast; 25 parts of citric acid as acidifier, 8 parts of malic acid and 27.3 parts of lactic acid; 0.6 parts of glucoside, 0.294 parts of zinc gluconate; 0.029 parts of copper gluconate and 1.5 parts of perfume were stirred. Water was added to make the resulting mixture 4,000 parts, which was dissolved and dispersed to a uniform state.

After the obtained solution was continuously sterilized, the bag was filled in an aluminum foil pouch with a stopper of 200 parts, and the container was sterilized at 90 ° C for 10 minutes. After the container is sterilized, a semi-solidified stomach-solid semi-solid nutrient for bagging is prepared under cooling.

(Example 2)

A semi-solidified semi-solid nutrient for gastrostomy was produced by the same method as in Example 1 except that the protein was changed to 150 parts of WPC392 (concentrated whey protein: manufactured by Fonterra Co., Ltd.).

(Example 3)

A semi-solidified semi-solid nutrient for gastrostomy was produced by the same method as in Example 1 except that the protein was changed to 140 parts of soy protein (Proleena 900; manufactured by Fuji Oil Co., Ltd.).

Table 1 below shows the composition, heat and pH of the semi-solid nutrient for gastrostomy of Examples 1 to 3.

(Comparative Example 1)

2000 parts of TM-Mini (Terumeal Mini coffee taste: manufactured by Terumo) was heated in water at 40 ° C for 30 minutes, and then 2000 parts of water was dispersed in 20 parts of seaweed, and boiled to confirm the dissolution of the amaranth. After heating, 2000 parts of TM-Mini was added to 2020 parts of the solution containing the dispersed amaranth, and after stirring for 30 seconds, 4020 parts of the mixed solution was obtained. Then, the mixed solution was pipetted by a catheter-type joint syringe (manufactured by Terumo Co., Ltd.), and allowed to stand at 4 ° C for 12 hours, and the cured person was used as a comparative sample.

"Assessment of semi-solid nutrient for gastric stoma"

(heat determination)

The general energy conversion factor, that is, the heat of the semi-solidified nutrient is calculated by the following formula, based on the saccharide 4 kcal/g, the protein 44 kcal/g, the lipid 9 kcal/g, and the dietary fiber 24 kcal/g.

[Number]

Calorie (kcal/g) = saccharide (g/g) × 4 (kcal / g) + protein (g / g) × 4 (kcal / g) + lipid (g / g) × 9 (kcal / g) + Food fiber (g/g) × 2 (kcal / g) (pH)

The pH of the semi-solidified nutrient was measured using a pH meter (METTLER TOLEDO MP220; METTLER TOLEDO). The results are presented in Table 1 above.

(trait)

The semi-solid nutrient for gastrostomy of Examples 1 to 3 and the properties of the comparative samples were visually judged. The results are presented in Table 1 above.

(viscosity measurement)

For the above-mentioned Examples 1 to 3, the semi-solid nutrient for gastric stoma and the comparative sample produced in the comparative example were subjected to viscosity measurement. This viscosity measurement was carried out using the following measurement equipment and conditions.

Meanwhile, the results of the viscosity measurement are shown in Table 2 which will be described later.

Measuring machine: B type viscometer

Manufacturer: BROOKFIELD

Type: DV-II+Pro

Measurement conditions: rotation speed 6 rpm

Measurement time 1min

Rotor number 64

Measuring temperature at room temperature (25 ° C)

(Measurement of residual rate in shape change evaluation test)

With respect to the semi-solid nutrient for gastric stoma of the above Examples 1 to 3 and the comparative sample produced in the comparative example, the residual rate of the shape change evaluation test in the artificial gastric juice and the artificial intestinal juice was measured. The residual rate measurement of the shape change evaluation test was carried out using the following measuring apparatus and conditions.

(1) Shape change evaluation test in artificial gastric juice

500 mL of artificial gastric juice (pH 1.2, manufactured by Kanto Chemical Co., Ltd.) was added to a beaker of a dissolution tester (Toyama Industries), and after heating at 37 ° C for 30 minutes, 100 g of the sample was separately prepared in the solution (the above Example 1 to The semi-solid nutrient for the gastrostomy of 3 and the comparative sample prepared by the comparative example were injected with a syringe. After the stirrer of the dissolution tester was not in contact with the sample, and rotated at a speed of 3 revolutions per minute for 5 minutes, the dissolution tester was stopped, and the solution was poured into the 60 mesh together with the sample separately dispersed in the liquid. On the mesh screen, the solid fraction on the mesh was used as a residue and its weight was measured. The bolus residual ratio (%) was calculated from the ratio (%) of the weight (g) of the residue in an amount of 100 g injected into the beaker. The results are presented in Table 2, Table 3-1 and Table 3-2 below.

(2) Shape change evaluation test in artificial intestinal juice

500 mL of artificial intestinal juice (pH 6.8, Kanto Chemical Co., Ltd.) was added to a beaker of a dissolution tester (Toyama Industries), and after heating at 37 ° C for 30 minutes, 100 g of the sample was placed in the solution (the above Example 1 to The semi-solid nutrient for the gastrostomy of 3 and the comparative sample prepared by the comparative example were injected with a syringe. After the stirrer of the dissolution tester was not in contact with the sample, after rotating at a speed of 65 rpm for 60 minutes, the dissolution test machine was stopped, and the solution was poured into a mesh of 60 mesh together with the sample separately dispersed in the liquid. Above, the solid fraction on the mesh was used as a residue, and the weight was measured. The bolus residual ratio (%) was calculated from the ratio (%) of the weight (g) of the residue in an amount of 100 g injected into the beaker. The results are presented in Table 2, Table 3-1 and Table 3-2 below.

The semi-solid nutrient solution of the gastrostomy of Example 1 was injected into the artificial intestinal juice, and after rotating at a speed of 65 rpm for 60 minutes, the shape change evaluation test was shown in the photograph of Fig. 1. In the first drawing, the photograph on the left side shows the state in which the beaker of the dissolution tester is viewed from the side, and the photograph on the right side shows the state in which the beaker of the dissolution tester is observed from above.

Further, after the comparative sample of Comparative Example 1 was injected into the artificial intestinal juice and rotated at a speed of 65 rpm for 60 minutes, the shape change evaluation test was as shown in the photograph of Fig. 2. In the second picture, the photo on the left is The state of the beaker of the dissolution tester was observed from the side, and the photograph on the right side shows the state of the beaker of the dissolution tester as viewed from above.

Tables 3-1 and 3-2 below are graphs showing the residual ratios of the semi-solid nutrient for gastric stoma of Examples 1 to 3 in Table 2 and the comparative samples produced in the comparative examples.

From the above-mentioned 1st, 2nd, 1st, 3rd, and 3rd, it can be confirmed that the semi-solid nutrient for stomach and stomach of the present invention is excellent in decomposability in the intestine.

[Fig. 1] A photograph showing a state of a shape change evaluation test for a semi-solid nutrient for a gastrostomy according to an embodiment of the present invention.

[Fig. 2] A photograph showing the state of the evaluation test of the shape change of the semi-solid nutrient for gastrostomy of the comparative example.

Claims (6)

A semi-solid nutrient for gastric stoma comprising 7 to 17% by mass of saccharide and 1.5 to 6.5% by mass of protein, which is stirred at 65 rpm for 60 minutes in an artificial intestinal juice at 37 ° C, and then passed through a pore size of 300 μm. The boll rate of the net sieve calculated by the shape change evaluation test for measuring the weight of the residue is 20% or less (including 20%), and the viscosity at 25 ° C is 10,000 to 40,000 mPa. s, and its pH is 4.0 or less (including pH 4.0). The semi-solid nutrient for gastrostomy according to the first aspect of the patent application, wherein the calorific value per g is 0.5 to 0.9 kcal. The semi-solid nutrient for gastrostomy according to the first aspect of the patent application, wherein the moisture content is 91 to 177 ml of water/100 Kcal. A semi-solid nutrient for gastrostomy according to claim 1, which comprises fermented dietary fiber and non-fermentable dietary fiber in a ratio of 1:1.5 to 1:0.67. For example, the semi-solid nutrient for gastrostomy according to the first aspect of the patent application is rotated in a artificial gastric juice at 37 ° C for 3 minutes at 3 revolutions per minute, and then the shape change of the weight of the residue is measured through a mesh sieve having a pore size of 300 μm. Comment The ratio of the above-mentioned residue calculated by the price test was 80% or more (including 80%). For example, the semi-solid nutrient for gastrostomy according to the fifth aspect of the patent application is rotated in a manual gastric juice at 37 ° C for 3 minutes at a rotation of 3 revolutions per minute, and then the shape change of the weight of the residue is measured through a mesh sieve having a pore size of 300 μm. The bolus ratio indicated by the above-mentioned residue ratio calculated by the evaluation test was 20% or less (including 20%).