JP5329280B2 - Acid type liquid enteral nutrient - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an acidic liquid enteral nutrient which secures good emulsification stability even when being rendered acidic, has few insoluble matters, has low viscosity to excel in tube flowability, and can be ingested in supplementing nutrition to the old people and patients who require nutritional support. <P>SOLUTION: The acidic liquid enteral nutrient, comprising a protein, a lipid, a carbohydrate, a vitamin, a mineral, and a dietary fiber blended therein, and having pH of the range of 3-4, is obtained by: keeping the condition of containing the protein, the lipid, 200-5,000 unit of a protease per 1 g of the protein, 0.2-1 wt.% of an organic acid monoglyceride, and 0.1-0.7 wt.% of a pectin for 10-60 minutes so that the viscosity may be 5-40 mPa s, the weight of insoluble matters may be 0.5 g or less per 50 g of the nutrient when centrifuging for 60 minutes by 2,610&times;g; stopping the reaction of the protease in a range of pH 3-4 by acid addition; and homogenizing by a pressure of 50 MPa or more with a high pressure homogeneous machine; and thereafter sterilizing by heat. <P>COPYRIGHT: (C)2011,JPO&amp;INPIT

Description

The present invention is an acidic liquid type that can efficiently supply proteins, lipids, carbohydrates, vitamins, minerals, and dietary fiber to elderly people and patients who need nutritional supplementation by tube administration or oral intake. The present invention relates to an enteric nutrient and a method for producing the same.
More specifically, in an acidic liquid enteral nutrient that contains proteins, lipids, carbohydrates, vitamins, minerals, and dietary fiber and has a pH in the range of 3-4, the emulsion stability is good even after heat sterilization. Thus, the present invention relates to an acidic liquid enteral nutrient that is low in insoluble matter, low in viscosity, excellent in tube fluidity, and less likely to block the tube.

Enteral nutrition is more physiological than parenteral nutrition and is the first choice for nutritional supplementation when the digestive tract is functioning. In addition, it is highly useful because it can prevent bacterial translocation and prevent complications and shorten the length of hospital stay.
Liquid enteral nutrients used for enteral nutrition include a sufficient amount of protein, lipids, carbohydrates, vitamins, minerals, and dietary fiber necessary for the body in a well-balanced manner, and can be consumed in a normal diet. It is indispensable for providing nutrition to patients before and after surgery that cannot be performed, elderly people, etc., and promoting recovery and healing of their physical strength.
As a complication involving enteral nutrients used in enteral nutrition, there is tube obstruction during administration (Non-patent Document 1). The main causes are (1) aggregation of protein by acid, (2) insoluble matter, and (3) viscosity. Most enteral nutrients currently on the market are neutral at a pH of about 6.0 to 7.5, and when administered with the tube tip placed in the stomach, duodenum, or jejunum, the protein component is removed from the gastric juice or the intestine. It is said that, when contacted with an acid produced by bacteria, protein aggregates are generated at the tip of the tube and the tube is blocked (Non-patent Documents 2 and 3). Enteral nutrient insolubles, when the protein concentration is high, the dispersion stability of the protein is significantly reduced, and the protein aggregates and precipitates or gels due to heating during heat sterilization and becomes insoluble. Therefore, it is said that the tube is likely to be blocked at the portion where the tube diameter is further narrowed by the clamp that adjusts the flow rate. In general, the higher the protein concentration of the enteral nutrient, the higher the viscosity tends to be, and the flow rate decreases during administration, and tube obstruction is likely to occur (Non-patent Document 4). On the other hand, in the case of enteral nutrients using protein hydrolysates, the tube blockage is solved, but the emulsified state becomes unstable. Therefore, it is necessary to divide into powder type or two liquids and mix them at the time of use.

Therefore, if the pH of the enteral nutrient is prepared in the acidic range in advance and the protein can be hydrolyzed and stably dispersed, the protein will aggregate, precipitate, or gel, and enter the enteral nutrient. It is not insoluble, and even if the protein component comes into contact with the acid produced by gastric juice or intestinal bacteria, the protein component is less likely to aggregate, and the viscosity is lowered, making it possible to suppress tube blockage. .
Thus, conventional enteral nutrients have the above-mentioned problems, and in the market, proteins, lipids, carbohydrates, vitamins, minerals, and dietary fiber are contained in sufficient amounts in a well-balanced manner. Furthermore, a liquid enteral nutrient that has good emulsification stability after heat sterilization, little insoluble matter, low viscosity, excellent tube fluidity, and less tube clogging has been desired.
For the above problems, for example, an acidic type beverage composition containing a protein has already been described in the literature, that is, a polyglycerin fatty acid ester of HLB9 or higher, and 0.1 to 5.0 w / W% protein containing pH 3.0-4.2 acidic beverage (see Patent Document 1), whey protein concentrate, sugar alcohol and high intensity sweetener, whey protein content is 0 There is a low calorie acidic protein beverage having a pH of 3.2 to 3.8 (see Patent Document 2). However, when the protein concentration is adjusted to 3.5 w / v% or more, the dispersion stability of the protein is remarkably lowered, and the protein tends to aggregate / precipitate or gel due to heating during heat sterilization. The storage stability and fluidity were inferior. Moreover, there exists a composition characterized by including the component and honey which removed whey from fermented milk (refer patent document 3). However, it is known that when fermented milk is used, casein in the milk component aggregates and precipitates, the viscosity becomes high, and the tube fluidity is inferior. Thus, an acidic liquid enteral nutrient such as an acidic beverage composition having a high protein concentration and excellent storage stability and fluidity has not been known so far.

In addition, as a method using a stabilizer, for example, protein particles may be prevented from agglomeration, precipitation, phase separation, etc. under acidic conditions in which fruit juice, organic acid or the like is added to protein food such as fermented milk. There is an acidic protein stabilizer (see Patent Document 4) characterized in that it contains a sulfated polysaccharide extracted from red algae. However, since this acidic protein food uses sulfated polysaccharide extracted from red algae as a protein stabilizer, it has a problem of poor versatility and high viscosity. Furthermore, an acid milk gel composition characterized by containing gellan gum, agar, or soybean polysaccharide as an acid milk gel composition that is excellent in protein stability and can be prepared even at a low pH (see Patent Document 5). is there. However, this technology stabilizes milk protein components using soy dietary fiber and pectin, which are widely used as protein stabilizers, but it is suitable for acidic foods and drinks with a high content of protein and protein hydrolysates. If necessarily unsuitable there is, also, there is a problem that the viscosity increases.
Therefore, milk protein is used as a high-quality protein with high nutritional value, a sufficient amount of nutrients are blended in a well-balanced state, good emulsification stability after heat sterilization, little insoluble matter, low viscosity, and tube fluidity. There has been a long-awaited need for an acidic liquid enteral nutrient that is superior and less likely to cause tube obstruction.

Medical Safety Information, Pharmaceuticals and Medical Devices Agency, No. 1. November 2007 Maruyama Maruyama, et al., Examination of enteral feeding catheter occlusion mechanism using acidic enteral nutrient, intravenous enteral feeding, 23, 315-320 (2008) Satoshi Koyama, Katsuyoshi Hatakeyama, Complications and measures against enteral nutrition, nutrition evaluation and treatment, 24, 241-245 (2007) Edited by Katsuyoshi Hatakeyama, Parenteral Enteral Nutrition Handbook, P.I. 124 (2003)

JP-A-5-184341 JP 11-123069 A JP-A-6-98717 Japanese Patent Laid-Open No. 2002-125587 JP 2002-153219 A

  The object of the present invention has been made in view of the above circumstances, and is an acidic type liquid enteral in which protein, lipid, carbohydrate, vitamin, mineral, and dietary fiber are blended and the pH is in the range of 3-4. In the nutrient solution, the protein, the lipid, the lipid, so that the viscosity is 5 to 40 mPa · s and the weight of the insoluble matter is not more than 0.5 g per 50 g of the nutrient solution when centrifuged at 2610 × g for 60 minutes. A state containing 200 to 5000 units of protease, 0.2 to 1% by weight of organic acid monoglyceride and 0.1 to 0.7% by weight of pectin per 1 g of the protein is maintained for 10 to 60 minutes, After addition, the reaction of protease is stopped in the range of pH 3 to 4, homogenized at a pressure of 50 MPa or more with a high-pressure homogenizer, and then heat-killed as an acidic type liquid enteral nutrient. The emulsification stability is good, the insoluble matter is low, the viscosity is low, the tube fluidity is excellent, the tube does not clog easily, and it can be ingested when feeding elderly people or patients who need nutrition. An acidic type liquid enteral nutrient prepared as described above is provided.

As a result of intensive studies to achieve the above object, the inventors of the present invention blended proteins, lipids, carbohydrates, vitamins, minerals, and dietary fiber, and are acidic type liquids having a pH in the range of 3-4. In the enteral nutrient, the protein, the protein, and the like, so that the viscosity becomes 5 g or less per 50 g of the nutrient when the viscosity is 5 to 40 mPa · s and the weight of the insoluble matter is centrifuged at 2610 × g for 60 minutes. A lipid, 200 to 5000 units of protease per gram of the protein, 0.2 to 1 % by weight of an emulsifier which is at least one organic acid monoglyceride selected from monoglyceride , succinic acid monoglyceride, diacetyltartaric acid monoglyceride , and a degree of esterification a state which contains 0.1 to 0.7 wt% 50% or more of the high methoxyl pectin held in the range of 10 to 60 minutes The acid type liquid enteral nutrient that has been heat-sterilized after stopping the reaction of protease in the range of pH 3 to 4 by acid addition, homogenizing at a pressure of 50 MPa or more with a high-pressure homogenizer, protein, lipid, A sufficient amount of sugar, vitamins, minerals, and dietary fiber are blended in a well-balanced manner.Emulsification stability is good even after heat sterilization, there are few insolubles, viscosity is low, tube fluidity is excellent, and tube blockage occurs. It was found that a difficult acidic type liquid enteral nutrient can be obtained, and the present invention has been completed based on this finding.

That is, this invention is shown to the following (1)-(6).
(1) In an acidic liquid enteral nutrient containing a protein, lipid, carbohydrate, vitamin, mineral, and dietary fiber and having a pH in the range of 3 to 4, the viscosity is 5 to 40 mPa · s and 2610 At least the protein, the lipid, and 200 to 5000 units of protease per gram of protein, so that the weight of insoluble matter when centrifuged at xg for 60 minutes is 0.5 g or less per 50 g of the nutrient; .2 to 1% by weight of organic acid monoglyceride and 0.1 to 0.7% by weight of pectin are maintained in the range of 10 to 60 minutes, and protease reaction is carried out in the range of pH 3 to 4 by addition of acid. An acidic liquid enteral nutrient that is stopped and homogenized at a pressure of 50 MPa or higher with a high-pressure homogenizer and then sterilized by heating.
(2) The acidic type liquid enteral nutrient according to (1), wherein the protein is milk protein.
(3) The acidic type liquid enteral nutrient according to (1) or (2), wherein the protease is a microorganism-derived endoprotease.
(4) The acidic type liquid enteral nutrient according to any one of (1) to (3), wherein the organic acid monoglyceride is at least one emulsifier selected from succinic acid monoglyceride, citric acid monoglyceride, and diacetyltartaric acid monoglyceride. .
(5) The acidic type liquid enteral nutrient according to any one of (1) to (4), wherein the pectin is a high methoxyl pectin having an esterification degree of 50% or more.
(6) In the production of an acidic liquid enteral nutrient having a pH in the range of 3 to 4, comprising protein, lipid, carbohydrate, vitamin, mineral, and dietary fiber, at least the protein, the lipid, A state containing 200 to 5000 units of protease, 0.2 to 1% by weight of organic acid monoglyceride and 0.1 to 0.7% by weight of pectin per 1 g of the protein is maintained for 10 to 60 minutes, A method for producing an acidic liquid enteral nutrient that is sterilized by heating after the protease reaction is stopped in the range of pH 3 to 4 by addition and homogenized at a pressure of 50 MPa or more with a high-pressure homogenizer.

  As described above, the acidic type liquid enteral nutrient of the present invention contains protein, lipid, carbohydrate, vitamins, minerals, and dietary fiber, and has an acidic type liquid enteral liquid having a pH in the range of 3-4. In the enteral nutrient, the protein, the lipid, and the like so that the viscosity is 5 to 40 mPa · s, the weight of insoluble matter is 2610 × g, and the concentration is less than 0.5 g per 50 g of the nutrient. Maintaining a state containing 200 to 5000 units of protease, 0.2 to 1% by weight of organic acid monoglyceride and 0.1 to 0.7% by weight of pectin per gram of the protein for 10 to 60 minutes, An acidic type liquid enteral nutrient that has been sterilized by heating after stopping the reaction of protease in the range of pH 3 to 4 by acid addition, homogenizing at a pressure of 50 MPa or more with a high-pressure homogenizer, A sufficient amount of white matter, lipids, sugars, vitamins, minerals, and dietary fiber are blended in a well-balanced manner.Emulsion stability is good even after heat sterilization, there are few insolubles, viscosity is low, and tube fluidity is excellent. It is possible to provide an acidic type liquid enteral nutrient that is less likely to be obstructed and can be taken when feeding elderly people or patients who need nutrition.

Hereinafter, the acidic type liquid enteral nutrient of the present invention will be described in detail.
The acidic type liquid enteral nutrient of the present invention has a pH of 3 to 4, preferably 3.4 to 3.8. If the pH of the acidic type liquid enteral nutrient is lower than 3, the acidic type liquid enteral nutrient becomes strongly acidic and the flavor becomes poor. On the other hand, if it is higher than 4, heat sterilization becomes insufficient when bacteria are mixed during production.
The viscosity of the acidic liquid enteral nutrient of the present invention is 5 to 40 mPa · s, preferably 10 to 30 mPa · s, and more preferably 10 to 20 mPa · s. If the viscosity of the acidic liquid enteral nutrient is higher than 40 mPa · s, the tube fluidity is inferior when tube feeding is performed, and the administration of the acidic liquid enteral nutrient becomes difficult. On the other hand, if it is 5 mPa · s or more, it is close to the viscosity of water, has excellent tube fluidity, and does not easily block the tube.
Viscosity is measured according to the 7th edition Food Additives Official Document. General test method 28. Viscosity measurement method Method 2 Rotational viscometer method For example, it refers to a value measured using an RB80L viscometer (Toki Sangyo Co., Ltd.).
As for the weight of the insoluble matter of the acidic type liquid enteral nutrient of the present invention, 50 g of acidic type liquid enteral nutrient is centrifuged at 2610 × g for 60 minutes, and the precipitate obtained after removing the supernatant is used. It is wet weight. The operation of the centrifugation is not particularly specified, but the centrifugation condition is set to 2610 × g and 60 minutes in consideration of the performance of a general desktop centrifuge. Examples of the centrifuge include a table top centrifuge 2410 (Kubota Manufacturing Co., Ltd.).
The weight of the insoluble matter of the acidic type liquid enteral nutrient of the present invention is 0.5 g or less per 50 g, preferably 0.4 g or less per nutrient. When the weight of the insoluble matter of the acidic liquid enteral nutrient is greater than 0.5 g, tube fluidity is inferior when tube feeding is performed, and it becomes difficult to administer the acidic liquid enteral nutrient.

The protein used in the acidic liquid enteral nutrient of the present invention is not particularly limited as long as it is a protein that can be used as a food, but is preferably milk protein, more preferably casein or caseinate. Casein or caseinate may be a commercially available product, acid casein such as lactic casein or casein hydrochloride separated by a conventional method, caseinate such as sodium caseinate or potassium caseinate, or a mixture thereof. The casein used as a raw material is preferably as pure as possible. Specifically, the casein content of fat and lactose is 2% by weight or less and the casein purity is 80% by weight or more. When the purity of the raw material is low and contains a lot of impurities, the emulsion stability after heat sterilization cannot be obtained, or the flavor deterioration is recognized by heat sterilization.
The lipid used in the acidic type liquid enteral nutrient of the present invention is not particularly limited as long as it is a lipid that can be used as a food. For example, linseed oil, sesame oil, olive oil, sesame oil, rice bran oil, Animal oils such as vegetable oils such as safflower oil, perilla oil, soybean oil, corn oil, rapeseed oil, germ oil, palm oil, palm kernel oil, sunflower oil, cottonseed oil, palm oil, peanut oil, fish oil, milk fat, etc. Examples include fats and oils, medium chain fatty acids, and highly unsaturated fatty acids. These may be used alone or in combination of two or more. In addition, processed preparations such as DHA, EPA, and diacylglycerol can be added.

The protease used in the acidic type liquid enteral nutrient of the present invention is not particularly limited as long as it is a protease that can be used as a food, and various proteases derived from microorganisms, animals, or plants can be used. However, it is particularly preferable to use an endoprotease. For example, microorganism-derived endoproteases include microorganisms belonging to the genus Bacillus, Aspergillus, Lactococcus, Lactobacillus, Streptococcus, and Bifidobacterium, and animal-derived endoproteases include, for example, pancreatin. , Trypsin, chymotrypsin, and the like. Examples of plant-derived endoproteases include papain and bromelain, and microorganism-derived endoproteases are preferred. In animal-derived or plant-derived endoproteases, the acidic unit liquid enteral nutrient of the present invention cannot be obtained because the enzyme unit per enzyme protein is low.
In the present invention, the endoprotease includes any protease as long as it has endoprotease activity, but is preferably a protease that has low exoprotease activity or almost no exoprotease activity compared to endoprotease activity.
As the endoprotease used in the acidic liquid enteral nutrient of the present invention, only one kind of protease may be used alone, or two or more kinds of proteases may be used in combination. In addition to isolated and purified proteases, plant cells, animal cells, fungal bodies or disrupted products thereof having protease activity can also be used. In this specification, the term protease refers to fungal bodies having protease activity, It is used in the meaning including animal cells, plant cells, or crushed materials thereof.

The amount of protease used in the acidic type liquid enteral nutrient of the present invention is not particularly limited as long as the protein can be enzymatically treated. For example, the blending amount of protease can be appropriately adjusted within a predetermined range together with the treatment time and treatment temperature. When using endoprotease, the total amount of endoprotease per gram of protein is 200 to 5000 units, preferably 500 to 4000 units. If it is less than 200 units, the viscosity of the acidic type liquid enteral nutrient of the present invention will be high and the tube fluidity will be poor. If it exceeds 5000 units, the flavor of the acidic liquid enteral nutrient of the present invention may be reduced by heat sterilization. In addition, when these crushed materials are used for bacterial cells, animal cells, or plant cells having protease activity, the addition amount as a solid content is preferably 1% by weight or less based on the total weight. By setting the amount of protease in such a range, the emulsification stabilization effect of enteral nutrients is reduced, the thermal stability of enteral nutrients is reduced and precipitation occurs, and the proteolytic products of enteral nutrients are degraded. Odor generation can be prevented.
In the present specification, the unit of protease is applied as it is with conventional techniques and knowledge in the art as it is or with appropriate modifications. For example, dairy casein (Hermarsten Casein manufactured by Merck) is used at 37 ° C. When a reaction is performed for 60 minutes, the time when an amino acid corresponding to 100 μg of tyrosine is generated is defined as “1 unit”.

  The reaction conditions of the protease used in the acidic type liquid enteral nutrient of the present invention are not particularly limited as long as the protein can be treated with protease, and the reaction time and reaction temperature of the protease are appropriately adjusted within a predetermined range. be able to. For example, a predetermined amount of endoprotease is added, and the reaction time is 10 to 60 minutes, preferably 15 to 45 minutes, and the reaction temperature is maintained at 50 to 70 ° C., preferably 55 to 65 ° C. Let When reaction time is shorter than 10 minutes, the efficiency in manufacture of the acidic type liquid enteral nutrient of this invention will fall. When reaction time is longer than 60 minutes, the flavor of the acidic type liquid enteral nutrient of this invention may fall by heat sterilization. When reaction temperature is lower than 50 degreeC, the efficiency in manufacture of the acidic type liquid enteral nutrient of this invention will fall. When the reaction temperature is higher than 70 ° C., protease is deactivated, making it difficult to produce the acidic type liquid enteral nutrient of the present invention. After the protease treatment, acid addition is performed to deactivate the enzyme, but heating may be performed. The heating temperature is preferably in the range of 80 to 140 ° C.

The acidic type liquid enteral nutrient of the present invention may contain a protein or protein hydrolyzate conventionally used in foods without departing from the gist of the present invention. The origin of protein or protein hydrolyzate is animal protein such as whey, milk protein such as total milk protein (TMP), milk protein concentrate (MPC), egg white, collagen, protamine, etc. in addition to casein. Examples thereof include those produced from vegetable proteins such as protein, soybean, wheat and corn.
Examples of the organic acid monoglyceride used in the acidic type liquid enteral nutrient of the present invention include succinic acid monoglyceride, citric acid monoglyceride, diacetyltartaric acid monoglyceride, acetic acid monoglyceride, and lactic acid monoglyceride. Among these, succinic acid monoglyceride, citric acid monoglyceride, and diacetyltartaric acid monoglyceride are preferable.
Specific organic acid monoglycerides that can be used for the acidic type liquid enteral nutrient of the present invention are Poem K-30, Poem B-10, Poem W-60 (RIKEN Vitamin Co., Ltd.), Sunsoft No. 621B, Sunsoft No. 681NU, Sunsoft No. 641D (Taiyo Chemical Co., Ltd.).
The compounding quantity of the organic acid monoglyceride used for the acidic type liquid enteral nutrient of this invention is 0.2 to 1 weight%, Preferably it is the range of 0.3 to 0.5 weight%. If the blending amount of the organic acid monoglyceride is less than 0.2% by weight, the effect of the organic acid monoglyceride cannot be sufficiently exhibited, and the emulsified state cannot be maintained during storage, which is not preferable. On the other hand, if it exceeds 1% by weight, the flavor of the emulsifier becomes strong and is not suitable for oral intake, which is not preferable.
In addition, within the scope not departing from the gist of the present invention, a general-purpose emulsifier other than the organic acid monoglyceride, for example, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester and the like are added. Can be used.

As pectin used in the acidic type liquid enteral nutrient of the present invention, raw materials are widely present in plant tissues, but mainly from citrus peels such as lime, lemon and orange, apple pomace, beet pulp. Extracts can be used. Moreover, what is marketed normally can also be used.
The esterification degree of pectin used for the acidic type liquid enteral nutrient of the present invention is a high methoxyl pectin of 50% or more. At low methoxyl pectin with a degree of esterification lower than 50%, enteral nutrients gel.
Specific pectin that can be used for the acidic type liquid enteral nutrient of the present invention is GENU lectin type YM-150-LJ, GENU pectin type YM-115-LJ, GENU pectin type JM-115-H-J. , GENU pectin type JM-150-J, GENU pectin type JMJ-J (Taiyo Chemical Co., Ltd.), UNIPECTINE AYD 30T, UNIPECTINE AYD 358, and UNIPECTINE AYD 380B (Unitech Foods, Inc.).
The amount of pectin used in the acidic type liquid enteral nutrient of the present invention is 0.1 to 0.7% by weight, preferably 0.3 to 0.5% by weight. When the amount of pectin is less than 0.1% by weight, physiological functions such as defecation promoting action as dietary fiber cannot be sufficiently exhibited, which is not preferable. On the other hand, when it exceeds 0.7% by weight, the viscosity of the enteral nutrient becomes high and the tube fluidity is inferior.
In addition, within the range not departing from the gist of the present invention, general-purpose dietary fibers other than pectin, for example, guar gum enzyme degradation product, glucomannan, cellulose, hemicellulose, lignin, polydextrose, resistant polysaccharides may be mentioned. These may be used alone or in combination of two or more.

In the acidic type liquid enteral nutrient of the present invention, protein, lipid, 200 to 5000 units of protease, 0.2 to 1% by weight of organic acid monoglyceride and 0.1 to 0.7% by weight of pectin per gram of protein. The contained state is maintained for 10 to 60 minutes, preferably 15 to 45 minutes. When holding | maintenance is shorter than 10 minutes, the efficiency in manufacture of the acidic type liquid enteral nutrient of this invention will fall. When holding | maintenance is longer than 60 minutes, the flavor of the acidic type liquid enteral nutrient of this invention may fall by heat sterilization. Although the temperature to hold | maintain is not prescribed | regulated in particular, For example, it hold | maintains in the range of 50-70 degreeC, Preferably it is 55-65 degreeC. When temperature is lower than 50 degreeC, the efficiency in manufacture of the acidic type liquid enteral nutrient of this invention will fall. When the temperature is higher than 70 ° C., protease is deactivated, and it is difficult to produce the acidic type liquid enteral nutrient of the present invention.
In the acidic type liquid enteral nutrient of the present invention, the acid used for stopping the reaction of the protease by acid addition is not particularly limited, and examples thereof include citric acid, malic acid, lactic acid, hydrochloric acid and the like. Organic acids such as citric acid, malic acid and lactic acid are preferred. In addition, heating may be used as a method for stopping the reaction of the protease by addition of acid. In this case, the heating temperature is preferably in the range of 80 to 140 ° C.

In the acidic type liquid enteral nutrient of the present invention, homogenization is to make a mixed liquid containing water and oil into an emulsion, and further to atomize droplets of the emulsion. As one method of homogenization, for example, a stirrer having a rotating blade, a colloid mill having a disk rotating at high speed or a rotor and a fixed disk, an ultrasonic emulsifier, a homogenizer which is a kind of high-pressure pump (homogenizer), etc. A high-pressure homogenizer that can be homogenized at a pressure of 50 MPa or more is preferable.
In the acidic type liquid enteral nutrient of the present invention, the pressure by the high-pressure homogenizer is 50 MPa or more. When the pressure is lower than 50 MPa, there is a problem in emulsion stability such as oil layer separation occurring immediately after preparation or during storage.

The carbohydrates used in the acidic type liquid enteral nutrient of the present invention may be those conventionally used in foods, for example, starch, dextrin, glucose and fructose and other monosaccharides, maltose and lactose and the like. Sugar, sugar, granulated sugar, starch syrup, reduced starch syrup, honey, isomerized sugar, inverted sugar, oligosaccharide Sugar, etc.), flour koji, trehalose, sugar alcohol (maltitol, erythritol, sorbitol, palatinit, xylitol, lactitol, etc.), sugar-bound starch syrup (coupling sugar), and the like. These may be used alone or in combination of two or more.
In addition, conventionally known or future sweet ingredients can also be used in place of carbohydrates. Specifically, sweet ingredients such as aspartame, acesulfame potassium, sucralose, aritem, neotame, licorice extract (glycyrrhizin), saccharin, saccharin sodium, stevia extract, stevia powder and the like may be used.
When producing the acidic type liquid enteral nutrient of the present invention, components such as appropriate vitamins and minerals which are usually used can be blended depending on the kind of the product.

As vitamins used in the acidic type liquid enteral nutrient of the present invention, vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, pantothenic acid, folic acid, biotin, vitamin C, vitamin A, vitamin D, vitamin E, vitamin K etc. are mentioned, It is preferable to mix | blend these plurality in combination as much as possible. A vitamin derivative may be used as the vitamin.
The following range is suitable for the compounding quantity of a vitamin per 100 mL of acidic type liquid enteral nutrients.
Vitamin B1 0.1-40 mg, preferably 0.3-25 mg
Vitamin B2 0.1-20 mg, preferably 0.33-12 mg
Vitamin B6 0.1-60 mg, preferably 0.3-10 mg
Vitamin B12 0.1-100 μg, preferably 0.60-60 μg
Niacin 1-300 mg, preferably 3.3-60 mg
Pantothenic acid 0.1-55 mg, preferably 1.65-30 mg
Folic acid 10-1000 μg, preferably 60-200 μg
Biotin 1-1000 μg, preferably 14-500 μg
Vitamin C 10-2000 mg, preferably 24-1000 mg
Vitamin A 0-3000 μg, preferably 135-600 μg
Vitamin D 0.1-50 μg, preferably 1.5-5.0 μg
Vitamin E 1-800 mg, preferably 2.4-150 mg
Vitamin K 0.5-1000 μg, preferably 2-700 μg

  Examples of minerals used in the acidic type liquid enteral nutrient of the present invention include sodium, potassium, calcium, magnesium, phosphorus, iron, copper, zinc, manganese, selenium, iodine, chromium and molybdenum, and more than one of these is possible. It is preferable to combine them. These may be mix | blended as an inorganic electrolyte component, and may be mix | blended as an organic electrolyte component. Examples of the inorganic electrolyte component include alkali metal or alkaline earth metal salts such as chlorides, sulfates, carbonates, and phosphorus oxides. The organic electrolyte component includes an organic acid such as citric acid, lactic acid, amino acid (such as glutamic acid and aspartic acid), alginic acid, malic acid or gluconic acid and an inorganic base such as an alkali metal or alkaline earth metal. Examples include salts. For example, calcium chloride, calcium citrate, calcium glycerophosphate, calcium gluconate, calcium hydroxide, calcium stearate, calcium stearoyl lactate, calcium carbonate, calcium lactate, dihydrogen pyrophosphate, calcium sulfate, tricalcium phosphate, monophosphate Calcium hydrogen, calcium dihydrogen phosphate, uncalcined calcium, magnesium chloride, magnesium stearate, magnesium carbonate, magnesium sulfate, trimagnesium phosphate, ferric chloride, sodium ferrous citrate, iron citrate, iron citrate Examples include ammonium, ferrous gluconate, iron lactate, ferric pyrophosphate, ferrous sulfate, zinc gluconate, zinc sulfate, copper gluconate, and copper sulfate. In addition, iodine, selenium, chromium, molybdenum, manganese, etc. can be used even if trace element-containing microbial cells derived from microorganisms having trace element accumulation obtained by culturing in a medium containing a high concentration of trace element compounds. good.

As for the compounding quantity of a mineral, the following range is suitable per 100 mL of acidic type liquid enteral nutrients.
Sodium 5-6000mg, preferably 10-3500mg
Potassium 1-3500 mg, preferably 25-1800 mg
Magnesium 1-740 mg, preferably 25-300 mg
Calcium 10-2300 mg, preferably 250-600 mg
Phosphorus 1-3500 mg, preferably 25-1500 mg
Iron 0.1-55 mg, preferably 1-10 mg
Copper 0.01-10 mg, preferably 0.1-6 mg
Zinc 0.1-30mg, preferably 1-15mg
Manganese 0.01-11 mg, preferably 0.1-4 mg
Selenium 0.1-450 μg, preferably 1-35 μg
Chromium 0.1-40 μg, preferably 1-35 μg
Iodine 0.1-3000 μg, preferably 1-150 μg
Molybdenum 0.1-320 μg, preferably 1-25 μg

Although the calorie | heat amount per mL of the acidic type liquid enteral nutrient of this invention is not specifically limited, It is 0.5-2.0 kcal, Preferably it is 0.75-1.5 kcal. If the amount of heat per mL of the acidic liquid enteral nutrient is lower than 0.5 kcal, a nutritionally sufficient amount of heat cannot be obtained. If the amount of heat per mL of the acidic type liquid enteral nutrient is higher than 2.0 kcal, the viscosity of the acidic type liquid enteral nutrient after heat sterilization becomes high.
As mentioned above, although the acidic type liquid enteral nutrient of this invention was demonstrated, this invention is not limited to these, You may add another component, an additive, etc. as needed. For example, additives such as citric acid, tartaric acid, malic acid, succinic acid, lactic acid, glycerin, propylene glycol, gum arabic, pigments, fragrances, preservatives and the like used as usual food ingredients may be added as appropriate. .

In the production of the present invention, based on the composition range described above, if a method conventionally known as a production method of Examples and nutritional compositions described later, or a method newly provided in the future is used, The acidic type liquid enteral nutrient of the invention can be produced.
The acidic type liquid enteral nutrient in the present invention includes those in a state of being filled in a container or the like. In this case, a method of filling the container aseptically after preliminarily heat-sterilizing the preparation (for example, UHT sterilization method) A method using the aseptic filling method) or a method of heating and sterilizing the container together with the container (retort sterilization method, boil sterilization method) can be employed. In addition, in the UHT sterilization method, a direct injection method such as a steam injection method in which water vapor is directly blown into the beverage or a steam infusion method in which the beverage is heated by being injected into the water vapor, an indirect heating method using a surface heat exchange device such as a plate or tube It can carry out by well-known methods, such as. In any sterilization method, heat treatment at 130 to 150 ° C. for about 2 to 120 seconds is preferable. In the case of retort sterilization, heat treatment at 110 to 125 ° C. for about 4 to 30 minutes is preferable. In the case of boiled (high temperature and normal pressure) sterilization, the heat treatment is preferably performed at 70 to 95 ° C. for about 5 to 20 minutes when the pH of the liquid enteral nutrient is 4.6 or less.

Although it does not specifically limit as a container which accommodates the acidic type liquid enteral nutrient obtained by this invention, It is preferable that it is a form which a patient can ingest easily. For example, a plastic container, a plastic bottle, a cart can, a paper container such as Tetra Pak, an aluminum pouch, or a metal can.
As a container to be used, soft synthetic resin (for example, plasticized vinyl chloride resin, polyurethane resin, polyethylene (PE) resin, polypropylene (PP) resin, ethylene-vinyl acetate copolymer (EVA), ethylene-α- A flexible container that is a sealed type formed of various polyolefin resins such as an olefin copolymer, polyfluorocarbon, polyimide, and the like and can be heat sterilized is preferable. Moreover, a container formed of a material obtained by laminating a paper and an aluminum foil and a synthetic resin (for example, polyethylene) on the inner surface side of the container can also be used. This laminated container is suitable for the aseptic packaging method.
In addition, resins used in medical containers and the like can be used as appropriate. Gas barrier resin layers such as polyethylene terephthalate (PET), polyethylene naphthalate (PEN), ethylene-vinyl alcohol copolymer (EVOH), polyvinylidene chloride (PVDC), polyacrylonitrile, polyvinyl alcohol, polyamide, polyester, and aluminum foil , Layer with gas barrier properties such as aluminum vapor deposition film, silicon oxide film, aluminum oxide film, etc. If the container is required to be transparent, choose a transparent one of these, and it is necessary for the above soft synthetic resin It is preferable to use as a layer component of a film combining suitably.

The production method of the acidic type liquid enteral nutrient of the present invention includes protein, lipid, 200 to 5000 units of protease per 1 g of the protein, 0.2 to 1% by weight of organic acid monoglyceride and 0.1 to 0.7. The state containing 10% by weight of pectin is maintained in the range of 10 to 60 minutes, the reaction of the protease is stopped in the range of pH 3 to 4 by acid addition, homogenized at a pressure of 50 MPa or more with a high-pressure homogenizer, and then heated. It is characterized by being sterilized. 10 to 10 states that do not contain any of the protein, the lipid, 200 to 5000 units of protease per gram of the protein, 0.2 to 1% by weight of organic acid monoglyceride, and 0.1 to 0.7% by weight of pectin If the product is held for 60 minutes, the reaction of protease is stopped in the range of pH 3 to 4 by acid addition, homogenized at a pressure of 50 MPa or more with a high-pressure homogenizer, and then heat sterilized, the weight of insoluble matter Is more than 0.5 g per 50 g of the nutrient when it is centrifuged at 2610 × g for 60 minutes.
In addition, carbohydrates, vitamins, minerals, and dietary fibers other than pectin in the amount required for the reaction of the protease can be blended in a timely manner.
The acidic type liquid enteral nutrient obtained in this way contains a sufficient amount of proteins, lipids, carbohydrates, vitamins, minerals, and dietary fiber in a well-balanced manner, and has good emulsification stability even after heat sterilization. Insoluble matter is low, viscosity is low, tube fluidity is excellent, tube blockage is unlikely to occur, and it can be ingested when feeding nutrition to elderly people or patients who need nutrition.

  EXAMPLES Next, although an Example is given and this invention is demonstrated further in detail, this invention is not limited to these.

Example 1
Based on the formulation shown in Table 1, it was prepared by the method of Preparation Method 1 described later to obtain the acidic type liquid enteral nutrient of the present invention. In Table 1, the compositions of mineral mix, fat-soluble vitamin mix, and water-soluble vitamin mix are shown in Table 2, Table 3, and Table 4, respectively. The obtained acidic type liquid enteral nutrient contains no agglomerates even when mixed with the first solution of the dissolution test, the amount of insoluble matter is 0.434 g, the viscosity is 28 mPa · s, and stored at 40 ° C. for 30 days. Even after this, the emulsion stability was good.

(Preparation method 1)
While stirring 6 kg of warm water at 65 ° C., pectin (high methoxyl pectin, GENU pectin type YM-150-LJ, Taiyo Kagaku Co., Ltd.), sodium dihydrogen phosphate, tripotassium citrate, sodium caseinate (casein sodium S, Japan Shinyaku Co., Ltd.) was added little by little, and stirred well to obtain an aqueous phase. Succinic acid monoglyceride (Sunsoft No. 681NU, Taiyo Kagaku Co., Ltd.) was added to the heated soybean oil as an emulsifier and dissolved to obtain an oil phase. After mixing the oil phase with the water phase and pre-emulsifying for 5 minutes with a propeller stirrer, endoprotease (Protease N “Amano” G, 192000 units / g, Amano Enzyme Inc.) was added and allowed to react for 30 minutes. . Thereafter, citric acid is added so that the pH becomes 3.8, and dextrin (Sandek # 150, Sanwa Starch Co., Ltd.), guar gum hydrolyzate (Sun Faber R, Taiyo Kagaku Co., Ltd.), sodium chloride, potassium chloride, Magnesium sulfate, calcium lactate, ferrous sodium citrate, zinc gluconate, copper gluconate, mineral mix, fat-soluble vitamin mix, water-soluble vitamin mix, and ascorbic acid were added and sufficiently stirred. Thereafter, water was added to make a total amount of 10 kg to obtain a raw material solution. The raw material solution is homogenized with a high-pressure homogenizer at a pressure of 50 MPa, and 200 mL of Cheerpack ST (registered trademark, Yoko Hosokawa) is filled in 200 mL portions, sealed, and boiled at 90 ° C. for 10 minutes. The sterilization process was implemented and the acidic type liquid enteral nutrient was obtained.

(Evaluation method 1)
Fifteenth revision Japan in which 20 mL of liquid enteral nutrient and 2.0 g of sodium chloride of Example 1 described above, Examples 2 to 6 and Comparative Examples 1 to 11 described later were dissolved in 7.0 mL of hydrochloric acid and water to 1000 mL After mixing 25 mL of the pharmacopoeia dissolution test first solution, the presence or absence of aggregates remaining on the sieve when passing through a No. 100 sieve was visually observed. The results are shown in Table 5.
In addition, the absence of aggregates is indicated by ○, and the presence of aggregates is indicated by ×.

(Evaluation method 2)
The viscosities of the liquid enteral nutrients of Example 1 described above and Examples 2 to 6 and Comparative Examples 1 to 11 described later were measured using an RB80L viscometer (Toki Sangyo Co., Ltd.). The results are shown in Table 5.

(Evaluation method 3)
After centrifuging the liquid enteral nutrient 50 g of Example 1 described above, Examples 2 to 6 and Comparative Examples 1 to 11 described later at 2610 × g for 60 minutes, the supernatant was removed, and the resulting insoluble matter was removed. The weight was measured. The results are shown in Table 5.

(Evaluation method 4)
The state immediately after the preparation of the liquid enteral nutrients of Example 1 described above, Examples 2 to 6 and Comparative Examples 1 to 11 described later, and after storage at 40 ° C. for 30 days was visually observed. The results are shown in Table 5.
○: Emulsification stability was good both immediately after preparation and after storage at 40 ° C. for 30 days.
Δ: The emulsified state immediately after preparation was good, but oil phase separation occurred after storage at 40 ° C. for 30 days.
X: Oil phase separation occurred immediately after preparation.

(Comparative Example 1)
In Example 1, the same preparation method as in Example 1 was repeated except that the endoprotease (Protease N “Amano” G, 192000 units / g, Amano Enzyme Inc.) was changed from 5 g to 0.2 g. I got a nutrient. The obtained acidic type liquid enteral nutrient contained no aggregates even when mixed with the first solution of dissolution test, but the amount of insoluble matter was 2.477 g and the viscosity was 48 mPa · s.

(Comparative Example 2)
In Example 1, the same preparation as in Example 1 except that high methoxyl pectin (GENU pectin type YM-150-LJ) was changed to low methoxyl pectin (GENU pectin type LM-101AS-J, Taiyo Kagaku Co., Ltd.). The method was repeated to obtain enteral nutrients. The obtained acidic type liquid enteral nutrient was gelled.

(Example 2)
In Example 1, except that 5 g of endoprotease (Protease N “Amano” G, 192000 units / g, Amano Enzyme Inc.) was changed to 0.5 g of Samoaze C160 (1830000 units / g, Daiwa Kasei Co., Ltd.) The same preparation method as in Example 1 was repeated to obtain an enteral nutrient. The obtained acidic type liquid enteral nutrient contains no agglomerates even when mixed with the first solution of the dissolution test, the amount of insoluble matter is 0.345 g, the viscosity is 28 mPa · s, and stored at 40 ° C. for 30 days. Even after this, the emulsion stability was good.

(Comparative Example 3)
In Example 2, the same preparation method as Example 1 was repeated except that pectin was changed to sodium carboxymethylcellulose (Serogen F-610BC, Daiichi Kogyo Seiyaku Co., Ltd.) to obtain an enteral nutrient. The obtained acidic type liquid enteral nutrient had an amount of insoluble matter of 0.492 g, but was mixed with the first solution of dissolution test to find aggregates, and the viscosity was 44 mPa · s.

(Comparative Example 4)
In Example 2, the same preparation method as Example 1 was repeated except that pectin was changed to carrageenan (GENULACTA type P-100-J, Taiyo Kagaku Co., Ltd.) to obtain an enteral nutrient. In the obtained acidic type liquid enteral nutrient, oil phase separation occurred immediately after preparation.

(Comparative Example 5)
In Example 2, an enteral nutrient was obtained by repeating exactly the same preparation method as in Example 1 except that pectin was changed to alginic acid ester (Chimiloid NLS-K, Kimika Co., Ltd.). In the obtained acidic type liquid enteral nutrient, oil phase separation occurred immediately after preparation.

(Comparative Example 6)
In Example 2, an enteral nutrient was obtained by repeating exactly the same preparation method as in Example 1 except that the pectin was changed to a microcrystalline cellulose preparation (Theolas RC-N81, Asahi Kasei Corporation). In the obtained acidic type liquid enteral nutrient, oil phase separation occurred immediately after preparation.

(Example 3)
In Example 2, the same preparation method as in Example 1 was repeated except that the amount of pectin was changed from 50 g to 30 g to obtain an acidic liquid enteral nutrient. The obtained acidic type liquid enteral nutrient contains no agglomerates even when mixed with the first solution of dissolution test, the amount of insoluble matter is 0.289 g, the viscosity is 20 mPa · s, and stored at 40 ° C. for 30 days. Even after this, the emulsion stability was good.

Example 4
In Example 2, the same preparation method as in Example 1 was repeated except that pectin was changed to GENU pectin type JM-150-J (Taiyo Chemical Co., Ltd.), which is a high methoxyl pectin. Got. The obtained acidic type liquid enteral nutrient contains no agglomerates even when mixed with the first solution of dissolution test, the amount of insoluble matter is 0.419 g, the viscosity is 20 mPa · s, and stored at 40 ° C. for 30 days. Even after this, the emulsion stability was good.

(Example 5)
In Example 2, the same preparation method as Example 2 was repeated except that succinic acid monoglyceride was changed to citric acid monoglyceride (Sunsoft No. 621G, Taiyo Kagaku Co., Ltd.) to obtain an enteral nutrient. The obtained acidic type liquid enteral nutrient contained no aggregates even when mixed with the first solution of the dissolution test, but the amount of insoluble matter was 0.444 g, the viscosity was 30 mPa · s, and 30 ° C. at 40 ° C. Even after storage for days, the emulsion stability was good.

(Example 6)
In Example 2, the same preparation method as in Example 2 was repeated except that the succinic acid monoglyceride was changed to diacetyltartaric acid monoglyceride (Poem W-60, Riken Vitamin Co., Ltd.) to obtain an enteral nutrient. The obtained acidic type liquid enteral nutrient contained no agglomerates even when mixed with the first solution of the dissolution test, but the amount of insoluble matter was 0.462 g, the viscosity was 34 mPa · s, and 30 ° C. at 40 ° C. Even after storage for days, the emulsion stability was good.

(Comparative Example 7)
In Example 2, the same preparation method as in Example 2 was repeated except that the amount of pectin was changed to 5 g to obtain an enteral nutrient. In the obtained acidic type liquid enteral nutrient, oil phase separation occurred immediately after preparation.

(Comparative Example 8)
In Example 2, the same preparation method as Example 2 was repeated except that the amount of pectin was changed to 100 g to obtain an enteral nutrient. The obtained acidic type liquid enteral nutrient contained no agglomerates even when mixed with the first solution of dissolution test, and the amount of insoluble matter was 0.498 g, but the viscosity was 80 mPa · s.

(Comparative Example 9)
In Example 2, succinic acid monoglyceride was changed to higher fatty acid monoglyceride (Sunsoft No. 8000V, Taiyo Kagaku Co., Ltd.) to prepare a liquid enteral nutrient by the method of Preparation Method 2 to obtain a liquid enteral nutrient . In the obtained acidic type liquid enteral nutrient, oil phase separation occurred immediately after preparation.

(Comparative Example 10)
In Example 2, succinic acid monoglyceride is changed to polyglycerin fatty acid ester (Sunsoft Q-17S, Taiyo Kagaku Co., Ltd.), liquid enteral nutrient is prepared by the method of Preparation Method 2, and liquid enteral nutrient is obtained. It was. In the obtained acidic type liquid enteral nutrient, oil phase separation occurred immediately after preparation.

(Comparative Example 11)
In Example 2, 40 g of succinic acid monoglyceride was changed to 10 g, and a liquid enteral nutrient was prepared by the method of Preparation Method 2 to obtain a liquid enteral nutrient. The obtained acidic type liquid enteral nutrient contained no agglomerates even when mixed with the first solution of dissolution test, and the viscosity was 28 mPa · s, but the amount of insoluble matter was 1.172 g, 40 ° C. Oil phase separation occurred after storage for 30 days.

(Preparation method 2)
While stirring 6 kg of warm water at 80 ° C., pectin, sodium dihydrogen phosphate, and tripotassium citrate were added little by little and stirred sufficiently. After cooling to 65 ° C., sodium caseinate was added little by little, and the mixture was sufficiently stirred to obtain an aqueous phase. Succinic monoglyceride was added to heated soybean oil and dissolved to obtain an oil phase. The oil phase was mixed with the aqueous phase, pre-emulsified with a propeller stirrer for 5 minutes, then endoprotease was added and reacted for 30 minutes. Then add citric acid to pH 3.8, further dextrin, guar gum hydrolysate, sodium chloride, potassium chloride, magnesium sulfate, calcium lactate, ferrous sodium citrate, zinc gluconate, copper gluconate, mineral Mix, fat-soluble vitamin mix, water-soluble vitamin mix and ascorbic acid were added and stirred thoroughly. Thereafter, water was added to make a total amount of 10 kg to obtain a raw material solution. The raw material solution is homogenized at a pressure of 50 MPa with a high-pressure homogenizer, and 200 mL of Cheerpack ST (Yoyuki Hosokawa) is filled 200 ml each, sealed, and boil sterilized at 90 ° C. for 10 minutes. The acid type liquid enteral nutrient was obtained.

(Preparation method 3)
While stirring 6 kg of warm water at 80 ° C., pectin, dextrin, guar gum hydrolyzate, sodium dihydrogen phosphate and tripotassium citrate were added little by little and stirred sufficiently. After cooling to 65 ° C., sodium caseinate was added little by little, and the mixture was sufficiently stirred to obtain an aqueous phase. Succinic monoglyceride was added to heated soybean oil and dissolved to obtain an oil phase. The oil phase was mixed with the aqueous phase, pre-emulsified with a propeller stirrer for 5 minutes, then endoprotease was added and reacted for 30 minutes. Then add citric acid to pH 3.8, further sodium chloride, potassium chloride, magnesium sulfate, calcium lactate, ferrous sodium citrate, zinc gluconate, copper gluconate, mineral mix, fat-soluble vitamin mix, Water-soluble vitamin mix and ascorbic acid were added and stirred thoroughly. Thereafter, water was added to make a total amount of 10 kg to obtain a raw material solution. The raw material solution is homogenized at a pressure of 50 MPa with a high-pressure homogenizer, and 200 mL of Cheerpack ST (Yoyuki Hosokawa) is filled 200 ml each, sealed, and boil sterilized at 90 ° C. for 10 minutes. The acid type liquid enteral nutrient was obtained.

  The present invention is an acidic type liquid enteral nutrient containing a protein, lipid, carbohydrate, vitamin, mineral, and dietary fiber, and having a pH in the range of 3 to 4, with a viscosity of 5 to 40 mPa · s and insoluble. The protein, the lipid, and 200 to 5000 units of protease per gram of protein, such that when the weight of the product is centrifuged at 2610 × g for 60 minutes, 0.5 g or less per 50 g of the nutrient, The state containing 2-1% by weight of organic acid monoglyceride and 0.1-0.7% by weight of pectin is maintained in the range of 10-60 minutes, and the reaction of protease is stopped in the range of pH 3-4 by addition of acid. It is an acidic type liquid enteral nutrient that is heat-sterilized after being homogenized at a pressure of 50 MPa or more with a high-pressure homogenizer, and has good emulsification stability and low insoluble matter after heat-sterilization. This is an acidic type liquid enteral nutrient that is low in viscosity, excellent in tube fluidity, less prone to tube clogging, and can be ingested when providing nutrition to the elderly or patients who need nutrition. Therefore, it can be used industrially.

Claims (3)

In an acidic liquid enteral nutrient containing a protein, lipid, carbohydrate, vitamin, mineral, and dietary fiber and having a pH in the range of 3 to 4, the viscosity is 5 to 40 mPa · s and 2610 × g. At least the protein, the lipid, 200 to 5000 units of protease per gram of protein, 0.2 to 0.2 so that the weight of insoluble matter after centrifugation for 60 minutes is 0.5 g or less per 50 g of the nutrient. Maintaining a state containing 1% by weight of organic acid monoglyceride and 0.1 to 0.7% by weight of pectin in the range of 10 to 60 minutes, and stopping the protease reaction in the range of pH 3 to 4 by addition of acid, after homogenization at a pressure greater than or equal to 50MPa by the high pressure homogenizer, a heat sterilization acidic type liquid enteral nutrient, the organic monoglyceride, Monogu succinate Celite, monoglyceride citrate, at least one emulsifier selected from diacetyl tartaric acid monoglyceride, wherein the pectin is a liquid enteral nutrient esterification degree is high methoxyl pectin more than 50%. The acidic type liquid enteral nutrient according to claim 1, wherein the protein is milk protein.   The acidic type liquid enteral nutrient according to claim 1 or 2, wherein the protease is a microorganism-derived endoprotease.