TWI544876B - Gastro-intubation with semi-solid nutrition - Google Patents

Description

Semi-solidified nutrient for gastric stoma

The present invention relates to a semi-solidified nutritional supplement for gastrostomy.

The enteral nutrition method is based on the physiological nutrient feeding route of the digestive tract. Because it can solve the problem of the high calorie infusion method, it is difficult for the patient who has difficulty in taking food by oral intake or chewing/swallowing function. For important nutritional investment methods.

In the enteral nutrition method, there are nasal nasal administration nutrition method and gastric ostomy oral administration nutrition injection method. The transnasal nutrition system is administered by the nasal cavity into the elongate tube in the stomach to deliver the enteral nutrient, so a liquid enteral nutrient is required. Therefore, the result takes a few hours or so in administration, and the burden on the patient or its caregiver is extremely large.

Further, in the long-term administration of enteral nutrition by the nasal administration of the nutrient method, there are many cases in which the complications of the inhalation pneumonia caused by the liquid nutrient in the gastrointestinal tract are caused.

In addition, the gastrostomy oral administration method refers to percutaneous endoscopic gastrostomy (PEG), which directly supplies (administers) nutrients from the outside of the body to the stomach by connecting the stomach tube. Management law. Compared with the conventional nasal tube nutrition method, the management is easy, the patient suffers less, and the feeding/swallowing is easy to rehabilitate. Therefore, in recent years, it has attracted attention as one of the useful management methods.

In PEG, the evaluation of enteral nutrition is reviewed by points (1) to (3) below. Pre-viscosity (viscosity) and conformality. (1) Prevention of aspiration pneumonia occurs by administering a liquid enteral nutrient to the stomach rapidly and then generating a gastroesophageal reflux. (2) By rapidly administering the liquid enteral nutrient to the stomach, the enteral nutrient is dumped from the stomach and rapidly absorbs the saccharide to make the blood sugar level unstable and cause squatting symptoms. prevent. (3) The liquid enteral nutrient is required to be administered to the patient in the same body for a long period of time in order to prevent the symptoms described in (1), but when the viscosity and shape retention are imparted to the enteral nutrient, In a short period of time. The result is a acne prevention that reduces the burden on the patient and contributes to an improvement in the quality of life (QOL) of the patient.

Various methods have been studied for the method of imparting viscosity to enteral nutrients. For example, in Patent Document 1, a method of adding a seaweed to an enteral nutrient is disclosed. Further, a colloidal liquid food containing acacia, sinosaur, carrageenan or the like (Patent Document 2) and a colloidal body which discloses a colloid of a protein and a colloidal agent colloid such as pectin and santillac gum are disclosed. A colloidal composition suitable for people with dysphagia (Patent Document 3) and the like.

[Previous Technical Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open Publication No. 2003-201230

[Patent Document 2] Japanese Patent Laid-Open Publication No. 2008-237186

[Patent Document 3] International Publication No. 99/34690

However, the semi-solidified nutrient prepared by using the seaweed has the property of being difficult to re-bond once it is pulverized. Therefore, when the container or the syringe is injected into the gastrostomy tube, the gel is colloidal (the colloid is broken and the small colloid-like pieces are gathered), and the colloidal sheet remains in the injection tube. Further, in the nutrient in which other compounds are blended in the amaranth, it is not sufficient in terms of viscosity, conformality, adhesion to the tube, and the like. In particular, when a nutrient is adhered to the tube, not only is it impossible to perform a reliable nutrient supply, but it is also required to be cleaned for a long period of time, and there is a problem that the work efficiency of the caregiver or the like is low.

Further, when a nutrient is administered to a patient, in the conventional semi-solidified nutrient, since the discharge resistance is high when the nutrient is extruded from the tube, the force at the time of extruding the nutrient must be large, and there is a large To increase the physical burden of the caregiver, etc.

Therefore, a semi-solidified nutrient is required which has a moderate viscosity, conformality, low adhesion to a tube, and a burden on the designer when administering a nutrient.

SUMMARY OF THE INVENTION An object of the present invention is to provide a semi-solidified nutrient which has high conformality even when extruded by a syringe or the like, has low adhesion to a tube, and has little resistance when extruded from a tube.

The inventors of the present invention have been concentrating on the results of repeated studies in view of the above problems, and found that the above problems can be solved by using a combination of agar and processed starch and further combining the use of seaweeds having different gel strengths as a seaweed. The present invention has been completed.

That is, the present invention relates to a semi-solidified nutritional supplement for gastrostomy as follows.

(1) A semi-solidified nutrient for gastric stoma, comprising: nutrients, acacia having a gel strength of 10 kPa or less (including 10 kPa), and agar having a gel strength of 30 kPa or more (including 30 kPa) and processing a starch having a gel strength of 10 kPa or less (including 10 kPa) and a total amount of the semi-solidified nutrient for the gastrostomy of 0.1 to 1% by mass; and the gel strength of 30 kPa or more. The content of the acacia (containing 30 kPa) is 0.01 to 0.2% by mass relative to the total amount of the semi-solidified nutrient for the above-mentioned gastrostomy; the content of the processed starch is relative to the semi-solidified nutrient for the above-mentioned gastrostomy The total amount is from 0.5 to 3% by mass.

(2) The semi-solidified nutrient for gastric stoma according to (1), which has a viscosity of 10,000 to 50,000 mPa at 25 ° C. s.

(3) A semi-solidified nutrient for a gastric stoma according to (1) or (2), which has a pH of from 3.0 to 4.5.

(4) The semi-solidified nutrient for gastric ostomy according to any one of (1) to (3), wherein the discharge pressure when discharged by a syringe at a speed of 60 mm/min is 15 kPa or less (including 15 kPa) ).

The semi-solidified nutrient for gastric ostomy of the present invention has high conformality when extruded by a syringe or the like, has low adhesion to a tube, and has little resistance when extruded from a tube. Therefore, the administered patient does not cause gastroesophageal reflux, and can surely take nutrients safely and easily.

[To implement the type of invention]

A semi-solidified nutrient suitable for a gastrostomy patient of the present invention is characterized in that it contains acacia and processed starch in the nutrient, and further uses a seaweed having different gel strengths.

In the case of this feature, unlike the nutrient which is the main body of the conventional amaranth or colloidal agent, it has a paste-like shape with high conformality. In this way, adhesion or stickiness accompanying an increase in the colloidalizing agent which has been a problem of the conventional nutrient can be suppressed, and therefore, when the stomach is administered into the stomach, the gastroesophage of the nutrient can be prevented from flowing backward. Further, it is possible to solve the problem of solving the problem of a work load or the like which causes cleaning by adhesion to the inside of the tube. Further, the caregiver or the like can easily squeeze out the nutrient from the tube, and has an effect of reducing the burden on the body.

Hereinafter, the semi-solidified nutrient for gastric ostomy of the present invention (hereinafter may also be referred to simply as a semi-solidified nutrient) will be described in detail.

[semi-solidified nutrient]

According to one embodiment of the present invention, the semi-solidified nutrient for gastric stoma comprises two or more kinds of vegetables and processed starch having different nutrient and gel strength.

[agar]

The polysaccharides of the red algae such as the genus Cauliflower and the genus Gracilaria vermiculophylla are frozen and dried, and are mainly composed of polysaccharides such as acacia powder or agaropectin. The above-mentioned acacia powder or gelatin sulfur has a structure in which galactose and 3,6-anhydrogalactose are mutually polymerized. Western cuisine with yam powder or glue The degree of polymerization or the molecular weight of the sulphur, the content of the sulphate group and the pyruvate group in the sauerkraut, etc., but the traits are different, but there is no particular limitation in the semi-solidified nutrient of the present type, either be usable. Moreover, when a highly elastic amaranth is used, the semi-solidified nutrient tends to be a nearly solid gel. On the other hand, when a soft-skinned amaranth is used, the semi-solidified nutrient tends to become a nearly liquid paste.

Western cuisine uses acacia with a gel strength of 10 kPa or less (including 10 kPa) (hereinafter also referred to as low gel strength weed) and acacia with a gel strength of 30 kPa or more (including 30 kPa) (hereinafter also referred to as For high gel strength weeds). Thus, by combining acacia having different gel strengths, the detailed mechanism is unknown, but it has an effect of suppressing the adhesion to the tube compared to the acacia having different gel strengths. Further, by combining low-gel strength agar vegetables, in addition to suppressing the discharge resistance when a nutrient is injected into a tube by a syringe or the like (hereinafter, such resistance is also referred to as injection resistance), suppressing the burden on the operator, and reducing the presence of nutrition Agglomerates in the agent.

The lower limit of the gel strength of the low gel strength amaranth is not particularly limited, and is generally 0.1 kPa or more (including 0.1 kPa). Further, the gel strength of the low gel strength amaranth is preferably from 0.1 to 10 kPa from the viewpoint of the combined effect of the above high gel strength. Further, the upper limit of the gel strength of the high gel strength amaranth is not particularly limited, and is generally 300 kPa or less (including 300 kPa). Further, the gel strength of the high gel strength of the seaweed is preferably from 30 to 200 kPa from the viewpoint of suppressing the injection resistance.

Commercially available products of high gel strength, such as: INA agar Karikorikan (manufactured by Ina Food Industry Co., Ltd., gel strength: 155 kPa), INA agar UM-11S (manufactured by Ina Food Industry Co., Ltd., gel strength: 66 kPa), INA agar UP-37 (manufactured by Ina Food Industry Co., Ltd., gel strength: 50 kPa), INA agar M-9 (manufactured by Ina Food Industry Co., Ltd.) Gel strength: 60 kPa) and the like. Commercial products of low gel strength can be enumerated, for example, ULTRA agar INA (manufactured by Ina Food Industry Co., Ltd., gel strength: 0.2 kPa), ULTRA agar UX-30 (manufactured by Ina Food Industry Co., Ltd., gel strength: 0.6 kPa) ), ULTRA agar AX-30 (manufactured by Ina Food Industry Co., Ltd., gel strength: 0.7 kPa), ULTRA agar BX-30 (manufactured by Ina Food Industry Co., Ltd., gel strength: 0.6 kPa), ULTRA agar UX-100 (Ina Food) Manufactured by an industrial company, gel strength: 3 kPa), ULTRA agar AX-100 (manufactured by Ina Food Industry Co., Ltd., gel strength: 3.5 kPa), ULTRA agar BX-100 (manufactured by Ina Food Industry Co., Ltd., gel strength: 3 kPa), ULTRA agar UX-200 (manufactured by Ina Food Industry Co., Ltd., gel strength: 5 kPa), ULTRA agar AX-200 (manufactured by Ina Food Industry Co., Ltd., gel strength: 5 kPa), ULTRA agar BX-200 (manufactured by Ina Food Industry Co., Ltd.) Gel strength: 5 kPa) and the like.

The high gel strength and the low gel strength can be used alone or in combination of two or more.

The ratio of the low gel strength of the seaweed to the high gel strength of the seaweed is based on the low gel strength of the seaweed: the high gel strength of the seaweed = 1:0.05 to 0.5, preferably from 1:0.05 to 0.2. good. In such a range, it is preferable to suppress the injection resistance.

In the present invention, the gel strength is a value measured by the following method. Dissolve the amaranth in hot water at 90 ° C to prepare a 1.0% by mass solution, at 4 After cooling for 24 hours at ° C, it was allowed to stand at 25 ° C for 2 hours, and then a rheometer CR-500DX manufactured by Sunkagaku Co., Ltd. was used. The measurement conditions were obtained by using a resinous plunger having a diameter of 15 mm and dividing the maximum load value at the compression rate of 60 mm/min by the plunger area to determine the gel strength. Three times were measured under the above conditions, and the gel strength was averaged.

The content of the amaranth having a gel strength of 10 kPa or less (including 10 kPa) is 0.1 to 1% by mass, preferably 0.2 to 1% by mass based on the total amount of the semi-solidified nutrient for the gastric ostomy. The content of the amaranth having a gel strength of 30 kPa or more (including 30 kPa) is 0.01 to 0.2% by mass, preferably 0.02 to 0.1% by mass based on the total amount of the semi-solidified nutrient for the gastric ostomy. When the blending amount of the low gel strength amaranth is less than 0.1% by mass, the above-mentioned effects may not be exhibited when the high gel strength of the seaweed is used in combination. In addition, when the blending amount of the low gel strength amaranth exceeds 1% by mass, the injection resistance when the nutrient is administered by the tube becomes high, which is not preferable. In addition, when the blending amount of the high gel strength of the amaranth is less than 0.01% by mass, the above effect may not be exhibited when the low gel strength of the seaweed is used in combination, and the gastroesophageal reflux may be caused by the low viscosity. The situation of the problem. In addition, when the blending of the high gel strength amaranth exceeds 0.2% by mass, the nutrient agent causes colloidalization, and uneven aggregation occurs in the nutrient, which may increase the adhesion of the nutrient to the tube, and thus is not preferable.

[Processed Starch]

By the use of the processed starch, when the agarwood is combined, the shape is maintained in addition to extrusion by a syringe or the like, and the injection resistance from the tube or the like can be suppressed. Moreover, the adhesion of the nutrient to the tube is inhibited.

Processed starch is a physical, enzymatic or chemical treatment of starch. By performing this treatment, for example, physical properties such as solubility in water, gelatinization temperature, stability of viscosity at the time of heat dissolution, and physical stability may vary.

Examples of the physical treatment include wet heat treatment, high frequency treatment, radiation treatment, bleaching treatment, acid treatment, and alkali treatment. Examples of the enzyme treatment include enzyme treatments such as α-amylase, β-amylase, glucoamylase 7, isoamylase, and pullulanase. Examples of the above chemical treatment include oxidation treatment, esterification treatment, acetonitrile treatment, etherification treatment, and crosslinking treatment.

The processed starch obtained by the above treatment is not particularly limited, and examples thereof include calcined dextrin, acid-treated starch, alkali-treated starch, bleached starch, enzyme-treated starch, sodium starch glycolate (Sodium Starch Glycolate), and sodium starch phosphate ( Sodium starch phosphate), acetylated adipic acid crosslinked starch, acetylated oxidized starch, acetylated phosphate crosslinked starch, sodium octenyl succinate starch, starch acetate, oxidized starch, hydroxypropylated phosphate Starch starch, hydroxypropyl starch, phosphoric acid crosslinked starch, phosphorylated starch, phosphoric acid monoesterified phosphoric acid crosslinked starch, and the like. Among these, it is preferred to use acetophosphoric acid crosslinked starch, hydroxypropylated phosphoric acid crosslinked starch, hydroxypropyl starch, and phosphoric acid crosslinked starch to use acetalized phosphoric acid crosslinked starch and hydroxypropylation. Phosphate crosslinked starch and hydroxypropyl starch are more preferred.

Processed starch can be prepared by itself or commercially available. When self-modulating, a conventional starch system can be prepared by performing at least one of the above physical treatment, enzyme treatment, and chemical treatment in the above starch. starch. Commercially available products can be, for example, WMS (Ethyl acetate cross-linked starch: manufactured by Matsutani Chemical Industry Co., Ltd.), Matsutani Suisen (Ethyl phosphate cross-linked starch: manufactured by Matsutani Chemical Industry Co., Ltd.), Farinex VA70WM ( Hydroxypropylated phosphate crosslinked starch: manufactured by Matsutani Chemical Industry Co., Ltd., Farinex VA70X (hydroxypropylated phosphate crosslinked starch: manufactured by Matsutani Chemical Industry Co., Ltd.), Farinex VA70C (hydroxypropylated phosphate crosslinked starch) : manufactured by Matsutani Chemical Industry Co., Ltd., Selectamile XF (hydroxypropylated phosphate crosslinked starch: manufactured by Matsutani Chemical Industry Co., Ltd.), Food Starch HR-7 (hydroxypropylated phosphate crosslinked starch: Matsutani Chemical Industry ( (manufactured by the company), Pine Ace # 1 (hydroxypropylated phosphate crosslinked starch: manufactured by Matsutani Chemical Industry Co., Ltd.), Matsutani Yugao (hydroxypropylated phosphate crosslinked starch: manufactured by Matsutani Chemical Industry Co., Ltd.), Matsutani Asagao (hydroxypropylated phosphate crosslinked starch: manufactured by Matsutani Chemical Industry Co., Ltd.), Farinex AG100 (hydroxypropyl starch: manufactured by Matsutani Chemical Industry Co., Ltd.), Matsutani Yuri (hydroxypropyl starch: Matsutani Chemical Industry Co., Ltd. ) Manufacturing) and so on.

The content of the processed starch is 0.5 to 3% by mass, preferably 0.7 to 2% by mass, based on the total amount of the semi-solidified nutrient for the gastric ostomy. When the blending amount of the processed starch is less than 0.5% by mass, the effect of maintaining the shape retaining property of the nutrient may be reduced when the container is extruded. Further, when the blended amount of the processed starch exceeds 3% by mass, it may become a cause of sticking, and this will increase the adhesion to the tube.

The processed starch may be used singly or in combination of two or more.

The semi-solidified nutrient for gastric stoma contains nutrients for the purpose of nutritional supplementation.

[nutrition]

Nutrients suitably contain saccharides as well as protein sources. Any one of the above nutrients may further contain at least one selected from the group consisting of a lipid, a vitamin, a mineral, and a dietary fiber.

The total amount of nutrients in the semi-solidified nutrient is preferably from 8 to 65 mass%, more preferably from 15 to 40 mass%.

(glycogen)

Glycogen, also known as carbohydrate, is the source of energy.

The saccharide to be used may be an energy source as long as it is absorbed by a living body, and is not particularly limited, and examples thereof include a monosaccharide, a disaccharide, and a polysaccharide. Specific examples of the monosaccharide include glucose, fructose, and galactose. Specific examples of the disaccharide include sucrose, lactose, maltose, isomaltose, and trehalose. Specific examples of the polysaccharide include starch (amylose, amylopectin), dextrin, and the like. Among these, it is better to use dextrin.

The dextrin coefficient is a general term for a substance in which α-glucose is polymerized by a glycosidic bond, and can be obtained by hydrolyzing starch. In the dextrins, the decomposition rate in the small intestine is slowed down and the absorption is slow, so that the blood sugar can be prevented from rising sharply. Further, by using dextrin, the osmotic pressure of the semi-solidified nutrient can be reduced, and the osmotic pressure can be prevented. The dextrin can be any one of a polymer dextrin having a high degree of polymerization of α-glucose and a low molecular weight dextrin dextrin having a low degree of polymerization of α-glucose, and a polymer dextrin which can lower the osmotic pressure is preferably used. In addition, low molecular ablextatin, also known as maltodextrin, is generally a polymer of 3 to 5 alpha-glucose.

The dextrin can be prepared by itself or by a commercially available person. In the preparation of dextrin, the conventional starch system, for example: corn, waxy corn, wheat, rice, waxy The starch contained in the waxy rice, waxy milo, beans (broad bean, mung bean, small red bean, etc.), potato, sweet potato, cassava, etc. can be prepared by hydrolysis by a conventional method. In addition, commercially available dextrin can be applied, for example, to TK-16 (manufactured by Matsutani Chemical Industry Co., Ltd.).

These saccharides may be used singly or in combination of two or more.

The saccharide content in the semi-solidified nutrient can be appropriately adjusted depending on the object to be adapted, but it is preferably 5 to 30% by mass based on the total amount of the semi-solidified nutrient. Moreover, the above processed starch is also a saccharide, wherein the so-called saccharide content comprises the amount of processed starch.

(protein source)

The protein source is not particularly limited, and a known person can be used.

The amino acid may, for example, be valine, leucine, isoleucine, lysine, methionine, phenylalanine, Essential amino acids such as threonine, tryptophan, histidine, etc.; and glycine, alanine, serine, cysteine Cysteine, asparagine, glutamine, proline, tyrosine, aspartic acid, glutamic acid Glutamic acid), a non-essential amino acid such as arginine. In addition to this, it also contains 4-hydroxyproline, 5-hydroxy-amino acid, γ -carboxy glutamic acid, O-Phosphoserine, O-Phosphotyrosine. Modified amines such as O-acetylserine, N ^ω -methyl arginine, Pyroglutamic acid, MN-N-formylmethionine Base acid; ornithine, citrulline, gamma -aminobutyric acid (GABA), thyroxine, s-Adenosylmethionine, etc. Amino acid. Further, the above amino acids may be stereoisomers (enantiomers, differeromers), may be positional isomers (Regioisomer), or may be such mixture. Further, the amino acid may be in the form of a mineral acid salt (hydrochloride or the like), an organic acid salt (acetate or the like), or an ester body (methyl ester or the like) which can be hydrolyzed in a living body.

The peptide can be obtained by polymerizing two or more of the above amino acids via a peptide bond (melamine bond). The peptide may be a dipeptide, a tripeptide, an oligopeptide (about 10 amino acids), or a polypeptide (approximately tens to hundreds of amino acids). The polypeptide includes a protein such as a plant protein or an animal protein. Further, some oligopeptides, for example, lactopeptide, casein dodecapeptide, and sardine peptide containing valyryl tyrosine, have health functions such as antihypertensive action.

Examples of the plant protein include proteins contained in rice such as rice, beans such as soybeans and tofu, and the like. Further, the soybean protein binds to bile acid and has a health function of promoting cholesterol excretion and the like.

Examples of the animal protein include proteins contained in eggs, meat, fish and shellfish, milk, and the like.

Among these, it is preferable to use whey protein containing milk (whey) as a raw material, casein protein contained in milk, or soybean protein, and it is preferable to use whey protein. The whey protein may, for example, be a concentrated whey protein (WPC: whey protein concentrate) or a whey protein isolate. (WPI: whey protein isolate), hydrolyzed whey peptide (WPH: Whey Peptide Hydrolysate) and the like. For example, WPI18855 (manufactured by Fonterra Co., Ltd.), WPI1822 (manufactured by Fonterra Co., Ltd.), WPI1895 (manufactured by Fonterra Co., Ltd.), WPC392 (manufactured by Fonterra Co., Ltd.), WPC, WPI, and soy protein, etc., may be used. WPC80 (manufactured by Fonterra), WPC7009 (manufactured by Fonterra), WPC164 (manufactured by Fonterra), WPC162 (manufactured by Fonterra), WPC132 (manufactured by Fonterra), WPC472 (manufactured by Fonterra), Proleena 900 ( Fuji Oil Co., Ltd.) ) Manufacturing), New fuji-pro 3000 (manufactured by Fuji Oil Co., Ltd.), New fuji-pro 1700 (manufactured by Fuji Oil Co., Ltd.), etc.

The above-mentioned protein, amino acid or peptide may be used singly or in combination of two or more.

The content of the protein source in the semi-solidified nutrient may be appropriately adjusted depending on the intended subject, and is preferably from 2 to 18% by mass based on the total amount of the semi-solidified nutrient.

(lipid)

Lipids can be used as a raw material for energy sources, biofilm constituents, steroid hormones and bile acids.

The lipid to be used is not particularly limited, and examples thereof include saturated fatty acids, unsaturated fatty acids, vegetable oils, animal fats, and fish oils.

Examples of the saturated fatty acid include caprylic acid, capric acid, lauric acid, palmitic acid, and stearic acid.

Examples of the unsaturated fatty acid include oleic acid, palmitoleic acid, and linoleic acid. Peanut oleic acid, a-linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA: Docosahexaenoic acid), and the like. In addition, EPA and DHA have health care functions such as an effect of suppressing an increase in blood cholesterol and an action of suppressing an increase in neutral fat.

The vegetable oil may, for example, be coconut oil, corn oil, cottonseed oil, olive oil, palm oil, palm kernel oil, peanut oil, rapeseed oil, safflower oil (safflower oil), sesame oil, soybean oil, sunflower oil, almond oil, Cashew nut oil, hazelnut oil, Australian walnut oil, mongongo oil, pecan oil, pine nut oil, pistachio oil, walnut oil, cucurbit seed oil, and Cucurbita foetidissima oil , pumpkin seed oil, watermelon seed oil, Amaranthus oil, apricot oil, apple oil, Argan oil, avocado oil, Babassu oil, moringa seed Oil), Borneo Tallow, Capesize Nut Oil, Cocoa Butter, Carob Oil, Cohune Palm, Quail Seed Oil, Wild Mango (Irvingia gabonensis) Oil, Linseed Oil, grape seed oil, hemp oil, kapok oil, Lallemantia iberica, Marula Oil, white mango seed oil (Meadowfoam Seed Oil), mustard oil, nutmeg (nutmeg butter), okra oil, papaya oil, perilla oil, brazil nut oil, pine nut oil, Poppy oil, western plum oil, quinoa oil, nigar seed oil Rice bran oil, royle oil, sacha inchi oil, camellia oil, Cirsium oil, tomato-seed oil, wheat oil, oyster sauce, Sunflower oil, germ oil, coconut oil, peanut oil, etc.

Examples of the animal fats and oils include lard, tallow, and milk fat.

The fish oil may be exemplified by fish oil such as squid, squid, squid, sardine, and saury.

Among these, it is preferred to use linoleic acid which is not synthesized in the human body, and a-linolenic acid or a lipid containing the same.

These lipids may be used singly or in combination of two or more.

The lipid content in the semi-solidified nutrient can be appropriately adjusted depending on the intended subject, but it is preferably from 1 to 8 mass% based on the total amount of the semi-solidified nutrient.

(vitamin)

Vitamins are a general term for saccharides, amino acids or peptides, and organic compounds other than lipids required to maintain the nutritional state of the organism.

Examples of vitamins include vitamin A (retinol), vitamin D (Ergocalciferol, Cholecalciferol), vitamin E (Tocopherol, Tocotrienol). ), fat-soluble vitamins such as vitamin K (phylloquinone, menaquinone); vitamin B1 (Thiamine), vitamin B2 (Riboflavin), vitamin B3 ( Niacin, Vitamin B5 (Pantothenic acid), Vitamin B6 (Pyridoxal Pyridoxamine, Pyridoxine), Vitamin B7 (Biotin) ), water-soluble vitamins such as vitamin B9 (folic acid), vitamin B12 (Cyanocobalamin, Hydroxocobalamin), Vitamin C (ascorbic acid). These vitamins may be used singly or in combination of two or more.

The vitamin content in the semi-solidified nutrient can be appropriately adjusted depending on the intended subject. Generally, for fat-soluble vitamins, an amount which does not cause an Excess symptom is added, and there is no limitation on the amount of addition of the water-soluble vitamin. The preferred content of each of the vitamins per 100 g of the semi-solidified nutrient is as follows.

[fat-soluble vitamins]

Vitamin A: preferably 0 to 3000 μg, more preferably 20 to 200 μg; vitamin D: preferably 0.1 to 50 μg, more preferably 0.1 to 5.0 μg; vitamin E: preferably 0.2 to 800 mg, more preferably 1 to 10 mg; vitamin K: preferably from 0.5 to 1000 μg, more preferably from 2 to 50 μg;

[water soluble vitamins]

Vitamin B1: preferably 0.01 to 40 mg, more preferably 0.1 to 10 mg; vitamin B2: preferably 0.01 to 20 mg, more preferably 0.05 to 10 mg; nicotinic acid (equivalent): preferably 0.1 to 300 mg NE, more preferably It is 0.5 to 60 mg of NE; pantothenic acid: preferably 0.1 to 55 mg, more preferably 0.2 to 30 mg; vitamin B6: preferably 0.01 to 60 mg, more preferably 0.1 to 30 mg; biotin: preferably 0.1 to 1000 μg, more preferably 1 to 100 μg; folic acid: preferably 1 to 1000 μg, more preferably 10 to 200 μg; vitamin B12: preferably 0.01 to 100 μg, more preferably 0.2 to 60 μg; vitamin C: preferably 1 to 2000 mg, more preferably It is 5 to 1000 mg.

(mineral)

Minerals are elements other than organic compounds required to maintain the nutritional status of the organism.

Examples of the minerals include macro-elements such as sodium, potassium, calcium, phosphorus, and magnesium; and essential trace elements such as iron, zinc, copper, iodine, manganese, selenium, chromium, and molybdenum. These minerals may be used singly or in combination of two or more.

The mineral content in the semi-solidified nutrient can be appropriately adjusted depending on the intended subject. The preferred content of each mineral per 100 g of semi-solidified nutrient is as follows.

[mass elements]

Sodium: preferably 5 to 6000 mg, more preferably 10 to 3500 mg; potassium: preferably 1 to 3500 mg, more preferably 25 to 1800 mg; calcium: preferably 10 to 2300 mg, more preferably 30 to 300 mg; It is preferably 1 to 3500 mg, more preferably 25 to 1500 mg; magnesium: preferably 1 to 740 mg, more preferably 10 to 150 mg;

[Required trace elements]

Iron: preferably from 0.1 to 55 mg, more preferably from 1 to 10 mg; zinc: preferably from 0.1 to 30 mg, more preferably from 1 to 15 mg; copper: preferably from 0.01 to 10 mg, more preferably from 0.06 to 6 mg; It is preferably 0.1 to 3000 μg, more preferably 1 to 150 μg; manganese: preferably 0.01 to 11 mg, more preferably 0.1 to 4 mg; selenium: preferably 0.1 to 450 μg, more preferably 1 to 35 μg; 0.1 to 40 μg, more preferably 1 to 35 μg; molybdenum: preferably 0.1 to 320 μg, more preferably 1 to 25 μg;

(food fiber)

Food fiber line has prevention: reduced nutrient availability, plasma cholesterol The function of alcohol reduction, improvement of blood glucose response, improvement of colorectal function, and prevention of colorectal cancer. Further, the dietary fiber is also fermented by intestinal bacteria and converted into a short-chain fatty acid, a carbonic acid gas, a hydrogen gas, a methane gas or the like. Among them, in terms of short-chain fatty acids, dietary fibers may become an energy source because they are absorbed by the large intestine.

The dietary fiber is not particularly limited, and examples thereof include cellulose, hemicellulose, lignin, insoluble pectose, chitin, chitosan, and Psyllium seed husk. Insoluble dietary fiber such as low molecular weight sodium alginate; water soluble pectin, guar gum, konjac mannan, glucomannan, alginic acid, acacia, chemically modified polysaccharides ( Chemically Modified Polysaccharides), polydextrose, indigestible fructooligosaccharides, maltitol, inulin, carrageenan, wheat bran, indigestible dextrin (eg: Pine) A water-soluble dietary fiber such as Fiber-C (manufactured by Matsutani Chemical Industry Co., Ltd.), polydextrose, guar gum decomposition product, or the like. These dietary fibers may be used alone or in combination of two or more.

The dietary fiber content in the semi-solidified nutrient can be appropriately adjusted depending on the intended subject.

[moisture]

The semi-solidified nutrient of the present invention suitably contains moisture

The moisture content of the semi-solidified nutrient can be appropriately adjusted depending on the intended subject or the desired viscosity, etc., but it is preferably 30 to 90% by mass based on the total amount of the semi-solidified nutrient, from the viewpoint of water management. On, to 50 More preferably 90% by mass.

[Other ingredients]

The semi-solidified nutrient of this type may further contain other conventional ingredients such as functional additives, food additives, tackifiers and the like.

(health function)

The health function component is a component that exerts a certain function on the living body by ingestion. For example, indigestible fructooligosaccharides, sugar alcohols, calcium citrate malate (CCM), and casein phosphopeptide (CPP), chitosan, L-arabinose, guava leaf polyphenols , wheat bran, soybean meal extract, diacylglycerol, dimercaptoglycerol plant sterol, soy isoflavone, milk basic protein (MBP: Milk Basic Protein) and the like.

[Indigestible Fructooligosaccharide]

The indigestible fructooligosaccharide refers to a sugar having a molecular weight of a polysaccharide (about 300 to 3,000 or so) which is a bond of a monosaccharide by a Glycosidic bond. The above-mentioned indigestible fructooligosaccharide cannot be decomposed by the digestive enzymes of the human body, and is contained in the above-mentioned saccharide for the decomposing enzymes which can be decomposed by the human body. The intestine effect can be obtained by ingesting indigestible fructooligosaccharides.

The indigestible fructooligosaccharide is not particularly limited, and examples thereof include xylo oligosaccharide, fructo-oligosaccharide, soybean oligosaccharide, isomaltto-oligosaccharide, and milk. Lacto-sucrose, lactulose, galactooligosaccharide, and the like. These indigestible fructooligosaccharides may be used singly or in combination of two or more. use.

The indigestible fructooligosaccharide content in the semi-solidified nutrient can be appropriately adjusted depending on the intended subject.

[sugar alcohol]

A sugar alcohol is a kind of sugar which is produced by reduction of a carboxyl group of an aldose or a ketose, and is poorly absorbed from the small intestine to the body and is difficult to be a calorie. Sugar alcohol is not easily metabolized by the acid produced by the bacteria in the mouth, and prevents the formation of tartar. This sugar alcohol can be used as a low-calorie sweetener.

The sugar alcohol may, for example, be erythritol, maltitol, palatinose or the like. These sugar alcohols may be used singly or in combination of two or more.

The content of the sugar alcohol in the semi-solidified nutrient can be appropriately adjusted depending on the intended subject.

Calcium citrate malate (CCM) and casein phosphopeptide (CCP) CCM and CPP promote calcium absorption and promote bone formation. The CCM and CPP can be used singly or in combination. Also, CCM and CPP are preferred for the combined use of calcium.

The content of CCM and CPP in the semi-solidified nutrient can be appropriately adjusted depending on the intended subject.

[Food Additives]

The food additive is used by adding, mixing, wetting or other methods to the food for the purpose of processing or preserving the food. The food additive may be, for example, a purpose of enhancing nutrition, such as zinc gluconate, copper gluconate, ascorbic acid diglucoside, cyclodextrin, preservative, antifungal agent, Antioxidants, colorants, sweeteners, pH adjusters, acidulants, emulsifiers and perfumes.

[Zinc Gluconate and Copper Gluconate]

Zinc gluconate and copper gluconate utilize gluconate, which is a high chelation energy with heavy metal ions of gluconic acid. When it is in the form of gluconate, it is easily absorbed, so it can effectively absorb zinc and copper. The zinc gluconate and copper gluconate may be used singly or in combination.

The content of zinc gluconate and copper gluconate in the semi-solidified nutrient can be appropriately adjusted depending on the intended subject.

[ascorbic acid diglucoside]

Ascorbic acid diglucoside is a compound in which glucose is a-coordinally bonded to the hydroxyl group at the 2-position of vitamin C (ascorbic acid), and is not attacked by oxygen, so it is a vitamin C derivative having higher stability than general vitamin C. . Vitamin C can be effectively absorbed by ascorbyl diglucoside.

The content of ascorbic acid diglucoside in the semi-solidified nutrient can be appropriately adjusted depending on the intended subject.

[cyclodextrin]

The cyclodextrin-based glucose is bonded via a glucosidic bond to form a cyclic oligosaccharide having a cyclic structure. The one formed by six glucoses is called a-cyclodextrin, the one made up of seven glucoses is called ß-cyclodextrin, and the one made up of eight glucoses is called γ-cyclodextrin. The cyclodextrin has a function of suppressing allergy, suppressing an increase in blood sugar level, and emulsification. The cyclodextrin may be used singly or in combination of two or more.

The content of cyclodextrin in the semi-solidified nutrient can be adapted to the applicable target. Local adjustment.

[Antioxidants]

The antioxidant has a function of preventing deterioration due to oxidation of the semi-solidified nutrient.

The antioxidant is not particularly limited, and for example, ascorbic acid and its sodium salt, erythorbic acid and its sodium salt can be used. These ascorbic acids may be used singly or in combination of two or more.

[Colorant]

The colorant has the function of beautifying the semi-solidified nutrient.

There are no special restrictions on coloring agents, but edible tar pigments (Food Color Red No. 2, No. 3, No. 40, No. 102, No. 104, No. 105 and No. 106; Food Color Blue No. 1 and No. 2; edible) can be used. Pigment yellow No. 4, No. 5; food coloring green No. 3, etc.), ß-carotene (ß-carotene), water-soluble fruit red (annatto), chlorophyll derivatives (chlorophyll a, chlorophyll b, chlorophyll copper, chlorophyll copper sodium , chlorophyll iron sodium), riboflavin, iron oxide, titanium dioxide, safflower yellow pigment, magenta, gardenia yellow, curcumin, red cabbage pigment, beet red pigment, grape skin Pigments, capsicum pigments, caramel, etc. These coloring agents may be used singly or in combination of two or more.

[sweetener]

The sweetener has a function of imparting sweetness to the semi-solidified nutrient.

There are no special restrictions on sweeteners, but saccharin and its salts, xylitol, aspartame, sucralose, oxaflufene, sweetener, cyclamate (cyclohexylaminosulfonic acid), neotame (neotame), trehalose, erythritol, maltose, Bara Glucose, Sorbitol, Licorice Extract, Stevia Sweet Processing Sweetener, Soma Sweet, Curculin, Disodium Glycyrrhizinate, and the like. These sweeteners may be used singly or in combination of two or more.

[pH adjuster]

The pH adjuster has the function of adjusting the pH of the semi-solidified nutrient.

The pH adjuster is not particularly limited, and citric acid, gluconic acid, succinic acid, potassium carbonate, sodium hydrogencarbonate, carbon dioxide, lactic acid, sodium lactate, sodium citrate, adipic acid, or the like can be used. These pH adjusters may be used singly or in combination of two or more.

[acidifier]

The acidifying agent has a function of imparting a sour taste to the nutrient, preventing oxidation of the food, and adjusting the pH and the like.

The acidifying agent is not particularly limited, and acetic acid, citric acid, succinic acid, lactic acid, malic acid, tartaric acid, gluconic acid, and phosphoric acid may be used. These acidifying agents may be used singly or in combination of two or more.

[emulsifier]

The emulsifier has a function of improving the solubility of oil-soluble components such as lipids in water and the like.

The emulsifier is not particularly limited, but a natural emulsifier such as lecithin, saponin or casein sodium; synthetic emulsification of glycerin fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, sucrose fatty acid ester or the like can be used. Agents, etc. These emulsifiers may be used singly or in combination of two or more.

[spices]

The fragrance has a function of scenting/smelling the semi-solidified nutrient.

There are no special restrictions on the fragrance, but acetophenone, a-pentanal aldehyde, anisaldehyde, benzaldehyde, benzyl acetate, benzyl alcohol, cinnamaldehyde, cinnamic acid, citral, citronellal, citronellol can be used. , furfural, decyl alcohol, ethyl acetate, ethyl cinnamate, ethyl decanoate, ethyl vanillin, eugenol, geranyl alcohol, isoamyl acetate, isoamyl butyrate, isoamyl phenylacetate Ester, DL-menthol, 1-menthol, methyl salicylate, piperonal, propionic acid, terpineol, vanillin, d-Borneol, and the like. These perfumes may be used singly or in combination of two or more.

[other]

Other enzymes such as a-amylase, ß-amylase, glucoamylase, glucose isomerase, trehalose-producing enzyme, trehalose-free enzyme, and glutamylase may be used.

The content of the above food additive in the semi-solidified nutrient can be appropriately adjusted depending on the intended subject.

[tackifier]

The tackifier has the function of imparting viscosity to the semi-solidified nutrient.

Adhesives other than agar and processed starch may also be appropriately combined and formulated. There are no special restrictions on tackifiers, but gelatin, pectin, guar gum, locust bean gum, glutinous mannose, celestial gum, tamarind gum, carrageenan, propylene glycol, carboxymethyl cellulose, and knots can be used. Blue gum, Tara gum, tamarind gum, psyllium gum, gum arabic, carterulgo polysaccharide, polytriglucose, sodium alginate, tragacanth gum, karaya gum, magnesium aluminum silicate (Veegum )Wait. These tackifiers may be used singly or in combination of two or more.

The content of the tackifier in the semi-solidified nutrient can be determined by considering the viscosity and the like. Ground adjustment.

Moreover, the viscosity of the semi-solidified nutrient of the present type is 10,000 to 50,000 mPa at 25 ° C. The s is better, with 14,000 to 30,000 mPa. s is better. The viscosity of the semi-solidified nutrient is 10,000 mPa. When it is s or more, it is preferable because gastroesophageal reflux or aspiration pneumonia is less likely to occur. On the other hand, the viscosity of the semi-solidified nutrient is 50,000 mPa. When it is s or less, it is preferable because it is easy to digest. The viscosity can be adjusted by appropriately setting the content of the agar and processed starch in the semi-solidified nutrient. Meanwhile, in the present specification, the "viscosity" is a value measured by the method described in the examples.

The heat of the semi-solidified nutrient of this type varies depending on the use of the semi-solidified nutrient, but preferably 0.5 to 2.5 kcal/g, and from the viewpoint of safety of water management, 0.5 to 1.0 kcal/ g is more preferable, but it is preferably 1.0 to 2.5 kcal/g when administered to a patient who restricts water or a burned patient. This heat can be adjusted by appropriately setting the addition amount of the saccharide, lipid, amino acid or peptide, and dietary fiber. Meanwhile, in the present specification, "heat" is a value measured by the method described in the examples.

The pH of the semi-solidified nutrient of this type is preferably from 3.0 to 4.5, more preferably from 3.5 to 4.0. When the pH is in the above range, it is preferable to suppress the growth of bacteria and to obtain a refreshing feeling. This pH can be adjusted under appropriate setting of the amount of addition of the pH adjuster, the oxidizing agent, and the like. Meanwhile, in the present specification, "pH" is a value measured by the method described in the examples.

The semi-solidified enteral nutrient system of this type has a discharge pressure of 15 kPa or less (including 15 kPa) when discharged from a syringe at a speed of 60 mm/min. Preferably, it is preferably 10 kPa or less (including 10 kPa). Thus, under the suppression of the injection resistance, the operator can greatly reduce the burden on the body. Here, the discharge pressure is a value measured by the method of the following examples.

[use]

The semi-solidified nutritional supplement of the present invention is for use in a gastrostomy. The gastrostomy nutrient refers to a nutrient which is administered through a gastric stoma in a managed nutrition administration method. The administration using a gastrostomy is for elderly or sick patients who have difficulty in oral intake and have normal functions of the intestines.

The semi-solidified nutrient of the present invention preferably comprises nutrients (ideal for saccharide and protein sources), moisture, a predetermined amount of amaranth, and a predetermined amount of processed starch. The content of the above nutrients is not particularly limited, and it is preferable to contain the amount of calories and nitrogen sources necessary for the organism which can satisfy the purpose of the enteral nutrition method. Further, the water content of the semi-solidified nutrient should be set in consideration of the state of the elderly person or patient to be administered, water management, and the like.

In addition, the component to be added is not particularly limited, and may be appropriately set depending on the administration method, the state in which the semi-solidified enteral nutrition agent is used, or the state of the patient. Also, in patients requiring systemic care, it is desirable to have the vitamins and minerals needed to maintain a nutritional status. In elderly people with low digestive function, food fibers are preferably added to improve constipation caused by administration of semi-solidified enteral nutrient.

The semi-solidified nutrient of this type adjusts the processed starch and the amaranth to a moderate viscosity, and balances the necessary nutrient sources, so it is suitable for elderly people with cerebrovascular disease with age reduction and cerebrovascular disease. , patients with neuromuscular disease (neuromyopathy), such as swallowing and chewing ability, due to consciousness The treatment of gastrointestinal tract function, the treatment of low-nutrition state, the prevention/treatment of reflux esophagitis, and the prevention of aspiration pneumonia in patients who are difficult to take orally, such as a disorder of consciousness, and postoperative patients / for treatment. In the case of administration, it is feared that there will be a squat and gastroesophageal reflux, and it is inevitable that it needs to be administered for a long time. However, the use of the semi-solidified nutrient of this embodiment can suppress the above-mentioned undesirable phenomenon, and It can be injected in a short time and easily, and it is expected to be extremely helpful in improving the quality of life (QOL) of patients and improving the efficiency of work in the care/care field.

[Manufacturing method of semi-solidified nutrient]

The semi-solidified nutrient of this type can be produced by a known method. For example, it can be produced by adding nutrients, acacia, processed starch and other desired ingredients to the heated water and stirring them. Further, any one of the solution in which the aqueous solution is dissolved in the heated water, the solution in which the processed starch is dissolved in the water, the nutrient and other desired components are added, and the two solutions are mixed and stirred to be produced.

The resulting semi-solidified nutrient can be made into a product, for example, by filling it into a container after continuous sterilization. The method of the continuous sterilization is not particularly limited, and examples thereof include ultra-high temperature short-time (UHT) sterilization (also called instantaneous sterilization), hot water sterilization, intermittent sterilization, and the like. The above sterilization should be carried out in a short time. By performing sterilization in a short period of time, deterioration of components contained in the semi-solidified nutrient can be suppressed.

The container for filling the semi-solidified nutrient is not particularly limited, and a conventional container can be used. The container can be exemplified by: Tetra Pak, paper cantocan, glass container, metal can, aluminum foil bag (aluminum) Pouch), plastic containers, etc. Among these, it is better to use a plastic container.

The raw materials of the above plastic containers are preferably polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polyvinyl acetate (PVAc), polycarbonate (PC), polybutylene terephthalate ( PBT), polyethylene naphthalate (PEN), ethylene-vinyl acetate copolymer (EVA), ethylene-a-olefin copolymer, polyfluorocarbon, and polyimine.

In the above plastic container, the following may be further suitably used in combination: polyethylene terephthalate (PET), polyethylene naphthalate (PEN), ethylene-vinyl alcohol copolymer (EVOH). , gas barrier resin such as polyvinylidene chloride (PVDC), polyacrylonitrile, polyvinyl alcohol, polyamide, polyester, etc.; gas barrier of aluminum foil, aluminum vapor deposition film, cerium oxide film, aluminum oxide film, etc. Inorganic layer. By installing the gas barrier layer, deterioration of the semi-solidified nutrient due to oxygen, water vapor, or the like can be prevented.

The above container may also be shielded from light. By this light shielding, for example, deterioration of light such as vitamin A, vitamin B2, vitamin C, and vitamin K contained in the semi-solidified nutrient can be suppressed.

The above-mentioned container can be used, for example, a soft bag (made by Fuji Seal International), a kettle bag (made by letterpress printing), and a jointed water bottle bag (Spouch; manufactured by Dainippon Printing Co., Ltd.). ; aluminum foil packaging (Cheer pack; manufactured by Hosokawa Electric Co., Ltd.).

[Examples]

Hereinafter, the present invention will be specifically described by way of examples, but the present invention is not limited thereto. In the meantime, the "parts" or "%" used in the examples means "parts by mass" or "% by mass" unless otherwise specified.

(Examples 1 to 10)

The following is a description of the blending method when feeding 4000 g. The blending amount of each raw material is shown in Table 1. Weigh 1200g of blended water in a 5L stainless steel bucket and heat it to 80 °C or more in a water bath. Then, the ARA Agar Karikorikan (manufactured by Ina Food Industries Co., Ltd.) and ULTRA agar INA (manufactured by Ina Food Industries Co., Ltd.) with a low gel strength of the seaweed are added, and the mixture is fully dissolved and then cooled to 50%. Protein added at 60 ° C (WPI; WPI 1895 (whey protein isolate: manufactured by Fonterra), WPC; WPC 392 (concentrated whey protein: manufactured by Fonterra), soy protein (Proleena (registered trademark) 900: Fuji Oil (manufactured by the company) and dextran (TK-16 (manufactured by Matsutani Chemical Industry Co., Ltd.)). In this solution, a lipid, a glycerin fatty acid ester as an emulsifier, and a processing are mixed at 50 to 55 °C. Mixing the dispersion of starch (WMS (Ethyl acetate cross-linked starch: manufactured by Matsutani Chemical Industry Co., Ltd.)). Further, a water-soluble multivitamin and a fat-soluble multivitamin as a vitamin are appropriately added; as a mineral Calcium gluconate, magnesium chloride, potassium chloride, sodium chloride, sodium dihydrogen phosphate and tripotassium citrate; guar hydrolysate as a dietary fiber (Sunfiber HG; solar chemistry (share)); indigestible dextrin ( Pine Fib er-C (manufactured by Matsutani Chemical Industry Co., Ltd.); integrated yeast; citric acid, malic acid, and lactic acid as an acidifying agent; ascorbic acid diglucoside; zinc gluconate; copper gluconate and spices, etc., and stirred. The mixed solution was made into 4000 parts, and then dissolved and dispersed to be in a uniform state.

The obtained solution was filled into the aluminum foil bag with the plug opening in a manner of 200 parts per bag after continuous sterilization, and the container was killed at 90 ° C for 10 minutes. Bacterial treatment. After the container is sterilized, the bagged semi-solidified nutrient is produced under cooling.

The total energy was calculated as (4 Kcal × saccharide content) + (9 Kcal × lipid content) + (4 Kcal × amino acid or peptide content) + (2 Kcal × dietary fiber content), and heat was expressed as Kcal per 1 g of the sample.

The pH was measured using a pH meter (METTLER TOLEDO MP220; METTLER TOLEDO) to determine the pH of the semi-solidified nutrient.

(Comparative Examples 1 to 6)

The following is a description of the blending method when feeding 4000 g. The blending amount of each raw material is shown in Table 2. 1200 g of blending water was weighed in a 5 L stainless steel drum, and heated to 80 ° C or higher (including 80 ° C) in a water bath. Next, the adhesion-promoting agent described in Table 2 was added, and after sufficiently dissolved, it was cooled to 50 to 60 ° C, and protein (WPI; WPI 1895 (whey protein isolate: manufactured by Fonterra)) and dextrin as a saccharide were added. (TK-16 (manufactured by Matsutani Chemical Industry Co., Ltd.)). In this solution, 50 to 55 ° C is mixed with a lipid, a glycerin fatty acid ester as an emulsifier, and a processed starch (WMS (acetylated phosphate crosslinked starch: The dispersion of the Matsutake Chemical Industry Co., Ltd. is mixed. Further, a water-soluble multivitamin, a fat-soluble multivitamin, which is a vitamin, is added as appropriate; calcium gluconate, magnesium chloride, potassium chloride, sodium chloride as a mineral , sodium dihydrogen phosphate and tripotassium citrate; guar hydrolysate as dietary fiber; integrated yeast; citric acid, malic acid and lactic acid as acidifying agents; ascorbic acid diglucoside; zinc gluconate; copper gluconate and spices The mixture was stirred, and water was added to make the resulting mixture 4,000 parts, which was dissolved and dispersed to a uniform state.

The resulting solution was continuously sterilized, and each bag was filled in an aluminum foil pouch having a plug opening so as to be 200 parts, and the container was sterilized at 90 ° C for 10 minutes. After the container is sterilized, the bagged semi-solidified nutrient is produced under cooling.

The obtained semi-solidified nutrient (Examples 1 to 10 and Comparative Examples 1 to 6) were observed for traits and various physical properties were evaluated. The evaluation method is as follows.

(1) Viscosity: After the semi-solidified nutrient was allowed to stand at 25 ° C for 24 hours, a B-type viscometer was used (label: Brookfield, style: DV-II + Pro, measurement conditions: rotation speed 6 rpm, measurement time 1 The measurement was performed in minutes, rotor No. 64, and measurement temperature at 25 ° C (room temperature).

(2) Injection resistance (kPa) (discharge pressure when discharged by a syringe at a speed of 60 mm/min): About 50 g of the sample was filled in a 50 mL catheter type syringe (Catheter tip syringe; manufactured by Terumo). A BARD gastrostomy tube (CRBard) having a diameter of 20 Fr and an inner diameter of 4 mm was placed in a syringe, and was discharged from the syringe at a speed of 60 mm/min using a universal testing machine (AGS-J: manufactured by Shimadzu Corporation). At the time, the pressure to be extruded (measurement temperature: room temperature 25 ° C) was measured.

(3) Shape retention: a 50 mL catheter-type syringe filled with a semi-solidified nutrient was connected to a tube having an inner diameter of 4 mm, and after extruding the semi-solidified nutrient from the syringe, the shape was visually confirmed and the conformal shape was judged. Sex. Moreover, conformality is judged based on the following criteria.

◎: The semi-solidified nutrient discharged from the syringe is not deformed by its own weight within about 10 minutes of discharge.

○: The semi-solidified nutrient discharged from the syringe is not deformed by its own weight within about 5 minutes of discharge.

△: The semi-solidified nutrient discharged from the syringe was slightly deformed after the discharge.

×: The semi-solidified nutrient that is spit out from the syringe changes greatly after being spit out. shape.

(4) Adhesion: Approximately 50 g of the sample was filled into a 50 mL catheter-type spun syringe (manufactured by Terumo), and a Bard gastrostomy tube (CRBard) having an outer diameter of 20 Fr and an inner diameter of 4 mm was placed in the syringe. Fill the tube with the sample and let it stand for 3 minutes. Then, 10 mL of water was passed through 1, 2, 3, 4, and 5 times, and after passing through water, the adhesion state of the sample in the tube was visually confirmed, and the evaluation was performed according to the following evaluation criteria.

◎: The inside of the tube was cleaned with 10 mL of water.

○: The inside of the tube was cleaned with 20 mL of water.

△: The inside of the tube was cleaned with 40 mL of water.

×: Even if it was washed with 40 mL of water, there was a residual of the semi-solidified nutrient in the tube.

(5) traits: The properties of the semi-solidified nutrient are judged by the naked eye.

(6) Uneven aggregation: For the semi-solidified nutrient, the uneven aggregation was evaluated by the naked eye according to the following evaluation criteria.

◎: The surface of the linear nutrient which was discharged from the container of about 20 cm had a smooth appearance.

X: The linear nutrient of about 20 cm was discharged from the container to have a rough surface appearance and partially agglomerated.

The results are presented in Table 3 below.

The nutrients of Examples 1 to 10, even if they have the same degree of viscosity as the nutritional agents of Comparative Examples 3 to 6, have low injection resistance from the syringe and excellent shape retention. It can be understood from this that the control of the injection resistance is not only a nutrient The viscosity factor is important for the combination of high gel strength of seaweed, low gel strength of seaweed and processed starch. Further, it was found that the adhesion of the nutrient in the tube can be suppressed as compared with the nutrient (Comparative Examples 3 to 6) using other colloidizing agents.

From the above results, it was found that the injection resistance of the nutrient solutions of Examples 1 to 10 from the injection tube was low. Further, these are nutrients which are excellent in shape retention, have less aggregation unevenness, and have less adhesion to a tube.

Claims (5)

A semi-solidified nutrient for gastric stoma, comprising: a nutrient, a gelatin having a gel strength of 10 kPa or less (including 10 kPa), an amaranth having a gel strength of 30 kPa or more (including 30 kPa), and processed starch, wherein the coagulation The content of the acacia having a rubber strength of 10 kPa or less (including 10 kPa) is 0.1 to 1% by mass based on the total amount of the semi-solidified nutrient for the above-mentioned gastrostomy; and the content of the above-mentioned gel strength of 30 kPa or more (including 30 kPa) is relative to The total amount of the semi-solidified nutrient for the gastrostomy is 0.01 to 0.2% by mass; and the content of the processed starch is 0.5 to 3% by mass based on the total amount of the semi-solidified nutrient for the gastrostomy. The semi-solidified nutrient for gastrostomy according to the first aspect of the patent application, which has a viscosity at 25 ° C of 10,000 to 50,000 mPa ‧ s. A semi-solidified nutrient for gastrostomy according to claim 1 or 2, which has a pH of 3.0 to 4.5. The semi-solidified nutrient for gastric ostomy according to the first or second aspect of the invention, wherein the discharge pressure when the syringe is discharged at a speed of 60 mm/min is 15 kPa or less (including 15 kPa). A semi-solidified nutrient for gastrostomy according to item 3 of the patent application, wherein the discharge pressure when discharged by a syringe at a speed of 60 mm/min The force is 15 kPa or less (including 15 kPa).