WO2023135991A1 - 容器、マイクロ流体デバイス、及びダイアフラムポンプ - Google Patents

容器、マイクロ流体デバイス、及びダイアフラムポンプ Download PDF

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Publication number
WO2023135991A1
WO2023135991A1 PCT/JP2022/045153 JP2022045153W WO2023135991A1 WO 2023135991 A1 WO2023135991 A1 WO 2023135991A1 JP 2022045153 W JP2022045153 W JP 2022045153W WO 2023135991 A1 WO2023135991 A1 WO 2023135991A1
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WIPO (PCT)
Prior art keywords
diaphragm
container
guide member
thin film
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2022/045153
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English (en)
French (fr)
Japanese (ja)
Inventor
輝 舩橋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nok Corp
Original Assignee
Nok Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nok Corp filed Critical Nok Corp
Priority to JP2023573904A priority Critical patent/JP7770426B2/ja
Priority to EP22920511.7A priority patent/EP4464894A4/en
Priority to US18/702,746 priority patent/US20250229268A1/en
Priority to CN202280067885.XA priority patent/CN118076809A/zh
Publication of WO2023135991A1 publication Critical patent/WO2023135991A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
    • B01F35/7137—Piercing, perforating or melting membranes or closures which seal the compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04—Pumps having electric drive
    • F04B43/043—Micropumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber

Definitions

  • the present invention relates to containers, microfluidic devices, and diaphragm pumps.
  • the container having the conventional structure only functions as a container for containing fluid.
  • the present invention provides a container, a microfluidic device, and a diaphragm pump that can easily control the flow rate of fluid and that can function as part of the structure of a diaphragm pump.
  • the present invention employs the following means to solve the above problems.
  • the container of the present invention is a case body having a cylindrical portion and having a fluid enclosed therein; a thin film that closes an opening on one end side of the cylindrical portion and is broken through to form a fluid outlet; a diaphragm that closes the opening on the other end side of the tubular portion; characterized by comprising
  • the fluid enclosed inside the case main body can be discharged.
  • the diaphragm since the diaphragm is pressed to cause the fluid to flow out, it is easy to control the flow rate of the fluid.
  • the container can also function as part of a diaphragm pump.
  • a lid portion that blocks the diaphragm from the external space on the opposite side of the thin film through the diaphragm.
  • the diaphragm is not exposed to the outside when storing or transporting the container.
  • the lid portion is provided integrally with the case body, and a boundary between the lid portion and the case body is formed by a thin portion, and the lid portion can be separated from the case body by tearing the thin portion. It should be configured to
  • the lid portion is provided with a handle portion for tearing the thin portion.
  • case main body is preferably made of a material having gas barrier properties.
  • the thin film is preferably made of a material having gas barrier properties.
  • the diaphragm is preferably made of an elastomer material.
  • the container can be attached to a microfluidic chip having an attached portion to which the case body is attached, a protrusion for breaking through the thin film, and a fluid channel.
  • the thin film is sandwiched between a first guide member and a second guide member, each of which has an insertion hole through which the protrusion is inserted, the first guide member is provided on the diaphragm side, and the second guide member is provided. is preferably provided on the side opposite to the first guide member with the thin film interposed therebetween.
  • the insertion hole suppresses the positional displacement of the protrusion, so that the protrusion breaks through the thin film smoothly.
  • a fluid is sealed in a space between the diaphragm and the first guide member, and the diaphragm-side surface of the first guide member is preferably formed of an inclined surface whose diameter decreases toward the insertion hole. .
  • the first guide member is made of hard material and the second guide member is made of elastomer material.
  • the first guide member enhances the function as a guide that suppresses the displacement of the protrusion, while the second guide member enhances the function of suppressing fluid leakage to the outside. can be done.
  • a guide member having an insertion hole through which the protrusion is inserted is provided between the case body and the thin film, and It is also preferable that a space between the diaphragm and the guide member is filled with a fluid, and the diaphragm-side surface of the guide member is formed of an inclined surface whose diameter decreases toward the insertion hole. be.
  • the microfluidic device of the present invention is a microfluidic chip having an attached portion to which the case body is attached, a protrusion for breaking through the thin film, and a fluid channel; the container attached to the microfluidic chip by attaching the case body to the attached portion; characterized by comprising
  • the diaphragm pump of the present invention is a microfluidic device as described above; a pressing member that presses the diaphragm; an actuator that reciprocates the pressing member; characterized by comprising
  • a container As described above, according to the present invention, it is possible to provide a container, a microfluidic device, and a diaphragm pump that can easily control the flow rate of fluid and that can function as part of the structure of a diaphragm pump. can be done.
  • FIG. 1 is a schematic diagram of a container according to Example 1 of the present invention.
  • FIG. 2 is a schematic cross-sectional view of a container according to Example 1 of the present invention.
  • FIG. 3 is a schematic diagram showing the state of the container according to Example 1 of the present invention when it is used.
  • FIG. 4 is a schematic diagram of a microfluidic chip to which the container according to Example 1 of the present invention can be applied.
  • FIG. 5 is a schematic diagram of a microfluidic device and a diaphragm pump to which the container according to Example 1 of the present invention can be applied.
  • FIG. 6 is a schematic diagram of a microfluidic device and a diaphragm pump to which the container according to Example 1 of the present invention can be applied.
  • FIG. 7 is a schematic cross-sectional view of a container according to Example 2 of the present invention.
  • FIG. 8 is a schematic cross-sectional view of a container according to Example 3 of the present invention.
  • FIG. 1 is a schematic diagram of a container according to Example 1 of the present invention.
  • FIG. 1(a) is a plan view of the container according to this embodiment, and
  • FIG. 1(b) is a back view thereof.
  • FIG. 2 is a schematic cross-sectional view of the container according to Example 1 of the present invention, and is a cross-sectional view taken along line AA in FIG. 1(a).
  • FIG. 3 is a schematic diagram showing the state of the container according to Example 1 of the present invention when it is used.
  • FIG. 1 is a schematic diagram of a container according to Example 1 of the present invention.
  • FIG. 3(a) is a plan view showing a state in which the lid portion of the container according to the present embodiment is removed
  • FIG. 3(b) is a cross-sectional view taken along line BB in FIG. 3(a).
  • FIG. 4 is a schematic diagram of a microfluidic chip to which the container according to Example 1 of the present invention can be applied.
  • FIG. 4(a) is a plan view of a microfluidic chip to which the container according to the present embodiment can be applied
  • FIG. 4(b) is a CC cross-sectional view in FIG. 4(a).
  • FIG. 5 is a schematic diagram of a microfluidic device and a diaphragm pump (Application Example 1) to which the container according to Example 1 of the present invention can be applied.
  • FIG. 5(a) is a schematic cross-sectional view of a microfluidic device to which the container according to the present embodiment can be applied.
  • the container corresponds to FIG. Equivalent to.
  • FIG. 5(b) is a schematic diagram of a pump to which the container according to the present embodiment can be applied, in which the container corresponds to FIG. 3(b) and the microfluidic chip corresponds to FIG. 4(b). do.
  • FIG. 6 is a schematic diagram of a microfluidic device and a diaphragm pump (Application Example 2) to which the container according to Example 1 of the present invention can be applied.
  • FIG. 1 Application Example 2
  • FIG. 6A is a schematic cross-sectional view of a microfluidic device to which the container according to this embodiment can be applied, and the container corresponds to FIG. 2 in the figure.
  • FIG. 6(b) is a schematic diagram of a pump to which the container according to the present embodiment can be applied, and in the figure, the container corresponds to FIG. 3(b).
  • the container 10 has a case 100 .
  • the material of this case 100 may be selected according to the fluid R enclosed in the case 100 .
  • the case 100 be made of a resin material having excellent gas barrier properties. Specifically, polyvinylidene chloride, ethylene-vinyl alcohol copolymer resin, and the like can be appropriately used. A multi-layer structure having layers of these resin materials having excellent gas barrier properties may also be used.
  • the case 100 integrally includes a case body 110 having a cylindrical portion, a lid portion 120 and a handle portion 121 . In this embodiment, the cylindrical portion of the case main body 110 is configured by a cylindrical portion.
  • the container 10 includes a thin film 200 that closes the opening on one end side of the cylindrical portion of the case body 110 .
  • the material of this thin film 200 may also be selected according to the fluid R sealed in the case 100 .
  • the fluid R is volatile, it is preferable to use a material with excellent gas barrier properties as the material of the thin film 200 .
  • the thin film 200 can be composed of a single-layer film made of an aluminum film, a plastic film, or the like, or a multi-layer film made of these materials.
  • the container 10 includes a diaphragm 300 that closes the opening of the case main body 110 on the other end side of the cylindrical portion.
  • the diaphragm 300 is desirably made of an elastomer material, particularly silicone rubber, which is excellent in chemical stability and biocompatibility. Target cells can be protected by using silicone rubber.
  • the cylindrical portion of the case body 110, the thin film 200, and the diaphragm 300 form a closed space.
  • a fluid R such as a sample or a reagent is sealed inside this sealed space.
  • the lid portion 120 described above is provided on the other end side of the case body 110 on the opposite side of the thin film 200 via the diaphragm 300 so as to block the diaphragm 300 from the external space. Thereby, volatilization of the fluid R in the closed space can be suppressed even if the diaphragm 300 has gas permeability.
  • the lid portion 120 is provided integrally with the case body 110 .
  • a boundary between the lid portion 120 and the case main body 110 is constituted by a thin portion.
  • grooves 131 and 132 having a circular planar shape are provided on the front and back surfaces, respectively, so that thin portions are provided. Accordingly, when the thin portion is torn, the lid portion 120 is separated from the case main body 110 .
  • the lid portion 120 is configured to be detachable from the case body 110 .
  • the lid portion 120 is provided with a handle portion 121 for tearing the thin portion, and when the user pulls the handle portion 121, the thin portion is torn and the lid portion 120 is removed from the case body 110. be able to. This allows the diaphragm 300 to be exposed during use.
  • FIG. 3 shows a state in which the lid portion 120 is removed from the case main body 110 .
  • FIG. 4 a microfluidic chip 400 to which the container 10 according to the present embodiment can be applied will be described.
  • a see-through portion is indicated by a dotted line.
  • the microfluidic chip 400 is a thin plate member made of acrylic, glass, resin material, or the like. This microfluidic chip 400 is provided with a concave portion 410 as an attached portion to which the case body 110 of the container 10 is attached.
  • the inner wall surface of the concave portion 410 is formed of a cylindrical surface, and is configured so that the outer peripheral surface of the cylindrical portion of the case main body 110 is fitted.
  • a protrusion 420 for breaking through the thin film 200 of the container 10 is provided in the center of the bottom surface of the recess 410 in the microfluidic chip 400 .
  • the microfluidic chip 400 is provided with a channel 430 for the fluid R so as to be connected to the concave portion 410 .
  • the microfluidic chip 400 is provided with a storage tank 440 provided so as to be connected to the channel 430, and an extraction port 450 for the fluid R.
  • FIG. 5(a) shows a microfluidic device 10S according to Application Example 1.
  • FIG. A microfluidic device 10S is composed of a microfluidic chip 400 and a container 10 .
  • the microfluidic chip 400 shown in FIG. 4 is used.
  • the microfluidic device 10S can be obtained.
  • the projection 420 breaks through the thin film 200 of the container 10 to form an outlet for the fluid R.
  • FIG. 5(b) shows a diaphragm pump 10T according to Application Example 1.
  • the diaphragm pump 10T includes a microfluidic device 10S and a pressing mechanism 500.
  • the lid portion 120 is removed from the case main body 110.
  • the pressing mechanism 500 includes a pressing member 510 that presses the diaphragm 300 of the container 10 and an actuator 520 that reciprocates the pressing member 510 .
  • Various known technologies such as a ball screw mechanism, a rack and pinion mechanism, a hydraulic mechanism, and a pneumatic mechanism can be used for the actuator 520 .
  • the solid-line pressing member 510 indicates a state separated from the diaphragm 300
  • the dotted-line pressing member 510 indicates a state in which the diaphragm 300 is pressed.
  • FIG. 6(a) shows a microfluidic device 10SA according to Application Example 2.
  • FIG. A microfluidic device 10SA is composed of a microfluidic chip 400A and a container 10 .
  • a microfluidic chip 400A according to this application example employs a configuration different from that of the microfluidic chip 400 shown in FIG.
  • the microfluidic chip 400A also includes a concave portion 410 as an attached portion, a projection 420, and a channel 430. As shown in FIG.
  • the microfluidic chip 400A according to Application Example 2 is provided with a concave portion 410 and a protrusion 420 on both sides of the channel 430, and is provided with a reservoir 440 and an outlet 450. Not done. However, although not shown, the microfluidic chip 400A is provided with vents used for releasing air from the channel 430, for example.
  • the microfluidic device 10SA can be obtained by fitting the case bodies 110 into the two concave portions 410 of the microfluidic chip 400A, respectively, and attaching the two containers 10.
  • the two containers 10 are attached to the microfluidic chip 400A, the thin film 200 of each container 10 is pierced by the projections 420 to form outlets for the fluids R1 and R2.
  • FIG. 6(b) shows a diaphragm pump 10TA according to Application Example 2.
  • the diaphragm pump 10TA includes a microfluidic device 10SA and a pair of pressing mechanisms 500.
  • the lid portion 120 is removed from the case main body 110.
  • the configuration of the pressing mechanism 500 is as described in the first application example. In this application example, for example, by alternately pressing the diaphragms 300 of the two containers 10 using the two pressing mechanisms 500 , the fluids R1 and R2 can be reciprocated within the flow path 430 .
  • different samples or reagents are used for the fluid R1 and the fluid R2, they can be mixed.
  • the container 10 of the present embodiment by pressing the diaphragm 300 with the outflow port formed in the thin film 200, the fluid sealed inside the case main body 110 can be discharged.
  • the diaphragm 300 is pressed to cause the fluid to flow out, it is easier to control the flow rate of the fluid than in the case of using a plastically deformable container.
  • the container 10 can function as part of the diaphragm pumps 10T and 10TA.
  • the diaphragm 300 Since the case 100 of the container 10 is provided with the lid portion 120 before use, the diaphragm 300 is not exposed to the outside during storage or transportation of the container 10 . Therefore, it is possible to prevent the fluid from leaking due to the diaphragm 300 being damaged or pushed.
  • the lid portion 120 is detachable from the case main body 110, and can be removed from the case main body 110 when the container 10 is used as the diaphragm pumps 10T and 10TA. Further, in this embodiment, the lid portion 120 can be easily separated from the case main body 110 by pulling the handle portion 121 . Furthermore, even if the diaphragm 300 has gas permeability, by forming the case 100 and the thin film 200 from a material having gas barrier properties, volatilization of the fluid R in the sealed space is suppressed before use. be able to.
  • the fluid enclosed in the container 10 can be supplied to the flow channel 430 of the microfluidic chips 400 and 400A. Therefore, it is possible to save space and reduce the number of parts.
  • microfluidic devices 10S and 10SA can be obtained by attaching the container 10 to the microfluidic chips 400 and 400A. Immediately after the container 10 is attached, the fluid R enclosed in the container 10 is ready to be supplied to the flow channel 430 provided in the microfluidic chips 400 and 400A. It can be suppressed.
  • FIG. 7 is a schematic cross-sectional view of a container according to Example 2 of the present invention, and corresponds to a cross-sectional view of the container cut at the same location as the cross-sectional view shown in FIG. 2 in Example 1.
  • FIG. 7 is a schematic cross-sectional view of a container according to Example 2 of the present invention, and corresponds to a cross-sectional view of the container cut at the same location as the cross-sectional view shown in FIG. 2 in Example 1.
  • the container 10A according to this embodiment also includes the case 100, the thin film 200A, and the diaphragm 300.
  • the case 100 and diaphragm 300 are as described in the first embodiment.
  • the structure of the thin film 200A itself is as described in the first embodiment, but the structure for attaching the thin film 200A to the case main body 110 is different from that in the first embodiment.
  • the thin film 200A is sandwiched between the first guide member 600 and the second guide member 700, both of which have insertion holes 610, 710 through which the protrusions 420 of the microfluidic chips 400, 400A are inserted. is configured to
  • the first guide member 600 is provided on the diaphragm 300 side, and the second guide member 700 is provided on the opposite side to the first guide member 600 with the thin film 200A interposed therebetween.
  • a first guide member 600 is fixed to the case main body 110 .
  • the first guide member 600 is made of a hard material (hard resin material or the like), and the second guide member 700 is made of an elastomer material such as rubber. Note that the container 10A according to this embodiment can be used in place of the container 10 in the microfluidic device and diaphragm pump shown in the first embodiment.
  • the container 10A configured as above, the same effect as in the first embodiment can be obtained.
  • the insertion holes 610 and 710 suppress the displacement of the protrusions 420, so that the protrusions 420 break through the thin film 200A smoothly. is performed on Moreover, since the first guide member 600 is made of a hard material, sufficient force can be applied when attaching the container 10A to the microfluidic chip. As a result, it is possible to prevent the container 10A from being insufficiently attached.
  • the second guide member 700 is made of an elastomer material such as rubber, it can be brought into close contact with the bottom surface of the concave portion 410 of the microfluidic chips 400 and 400A. As a result, leakage of the fluid to the outside can be suppressed more reliably.
  • Example 3 A container according to Example 3 of the present invention will be described with reference to FIG. In this embodiment, a configuration is shown in which the shape of the first guide member is different from that in the second embodiment. Since the basic configuration and action are the same as those of the second embodiment, the same components are denoted by the same reference numerals, and the description thereof will be omitted as appropriate.
  • FIG. 8 is a schematic cross-sectional view of a container according to Example 3 of the present invention, and corresponds to a cross-sectional view of the container cut at the same location as the cross-sectional view shown in FIG. 2 in Example 1.
  • FIG. 8 is a schematic cross-sectional view of a container according to Example 3 of the present invention, and corresponds to a cross-sectional view of the container cut at the same location as the cross-sectional view shown in FIG. 2 in Example 1.
  • FIG. 8 is a schematic cross-sectional view of a container according to Example 3 of the present invention, and corresponds to a cross-sectional view of the container cut
  • the container 10B according to this embodiment also includes the case 100, the thin film 200A, and the diaphragm 300.
  • the case 100 and diaphragm 300 are as described in the first embodiment.
  • the structure of the thin film 200A itself is as described in the first embodiment, but the structure for attaching the thin film 200A to the case main body 110 is different from that in the first embodiment.
  • the thin film 200A is sandwiched between the first guide member 600B and the second guide member 700, both of which have insertion holes 610, 710 through which the protrusions 420 of the microfluidic chips 400, 400A are inserted. is configured to
  • the first guide member 600B is provided on the diaphragm 300 side, and the second guide member 700 is provided on the opposite side to the first guide member 600 with the thin film 200A interposed therebetween.
  • the first guide member 600B is fixed to the case main body 110. As shown in FIG.
  • the first guide member 600B is made of a hard material (hard resin material or the like), and the second guide member 700 is made of an elastomer material such as rubber. Note that the container 10B according to this embodiment can be used in place of the container 10 in the microfluidic device and diaphragm pump shown in the first embodiment.
  • the surface 620 on the side of the diaphragm 300 is composed of an inclined surface whose diameter decreases toward the insertion hole 610.
  • the inclined surface is a tapered surface, but the inclined surface may have a configuration other than the tapered surface (for example, a curved surface instead of a straight line in the cross-sectional view). .
  • the same effect as in the first and second embodiments can be obtained.
  • the surface 620 on the side of the diaphragm 300 is formed of an inclined surface, when the fluid R flows out by pressing the diaphragm 300, the fluid remains in the container. can be suppressed.
  • the case 100 has the lid portion 120 .
  • the lid portion 120 may not be necessary.
  • the lid portion 120 in the case 100 is not essential, and the case 100 may be configured without the lid portion 120 .

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Reciprocating Pumps (AREA)
PCT/JP2022/045153 2022-01-11 2022-12-07 容器、マイクロ流体デバイス、及びダイアフラムポンプ Ceased WO2023135991A1 (ja)

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EP22920511.7A EP4464894A4 (en) 2022-01-11 2022-12-07 CONTAINER, MICROFLUIDIC DEVICE, AND MEMBRANE PUMP
US18/702,746 US20250229268A1 (en) 2022-01-11 2022-12-07 Container, microfluidic device, and diaphragm pump
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JPH09175538A (ja) 1995-12-22 1997-07-08 Bussan Dairekuto Maaketeingu Kk 液体・粘体等の使い捨て可能な収納容器
WO2015045134A1 (ja) * 2013-09-30 2015-04-02 株式会社日立製作所 試薬保持容器、送液装置、試薬吐出方法
WO2015186454A1 (ja) * 2014-06-05 2015-12-10 株式会社日立ハイテクノロジーズ 生化学用試薬類保存デバイス、及び生化学用分析装置
JP2017121970A (ja) 2013-03-15 2017-07-13 ジェンマーク ダイアグノスティクス， インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置

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CN113101986B (zh) * 2020-06-17 2022-09-16 京东方科技集团股份有限公司 一种用于试剂存储和释放的装置以及微流控装置

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JPH09175538A (ja) 1995-12-22 1997-07-08 Bussan Dairekuto Maaketeingu Kk 液体・粘体等の使い捨て可能な収納容器
JP2017121970A (ja) 2013-03-15 2017-07-13 ジェンマーク ダイアグノスティクス， インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
WO2015045134A1 (ja) * 2013-09-30 2015-04-02 株式会社日立製作所 試薬保持容器、送液装置、試薬吐出方法
WO2015186454A1 (ja) * 2014-06-05 2015-12-10 株式会社日立ハイテクノロジーズ 生化学用試薬類保存デバイス、及び生化学用分析装置

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See also references of EP4464894A4

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CN118076809A (zh) 2024-05-24
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EP4464894A4 (en) 2025-07-30
JP7770426B2 (ja) 2025-11-14
US20250229268A1 (en) 2025-07-17

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