Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
  • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
  • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
  • A01N37/22—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
  • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
  • A01N37/46—N-acyl derivatives
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
  • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
  • A01P7/00—Arthropodicides
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
  • A01P7/00—Arthropodicides
  • A01P7/04—Insecticides

Definitions

• the present invention relates to a method for controlling drug-resistant arthropod pests.
• Non-Patent Document 1 Various drugs have been used to control harmful arthropods, but it has been pointed out that the development of drug resistance can be a barrier to control.
• the present invention provides an effective control method for harmful arthropods that have acquired drug resistance.
• the present invention includes, but is not limited to, the following aspects.
• [1] Applying at least one compound selected from Group A to a harmful arthropod exhibiting resistance to at least one insecticide selected from Group B, or to its habitat or to a place where its appearance is expected
• a method for controlling arthropod pests exhibiting resistance characterized by: Group A: the group consisting of brofuranilide, nicofurprole, isocycloseram, and ciprofuranilide;
• Group B A group consisting of fluxametamide, pyrethroid compounds, oxadiazine compounds, and phenylpyrazole compounds.
• the pyrethroid compound of group B is at least one compound selected from the group consisting of permethrin, deltamethrin, cyhalothrin, cyfluthrin, cypermethrin, etofenprox, bifenthrin, and esfenvalerate.
• Control method [3] The control method according to [1], wherein the pyrethroid compound of Group B is at least one compound selected from the group consisting of permethrin and deltamethrin.
• Group A compounds (hereinafter sometimes abbreviated as compound A) and group B insecticides (hereinafter sometimes abbreviated as compound B) are both known compounds.
• Manual 18th -Edition (published by BCPC) ISBN 978-1-9998966-1-4", Recent Highlights in the Discovery and Optimization of Crop Protection Products (published by Academic Press) p . 170-171; ISBN 978-0-12-821035-2, WO2015/067646, or WO2020/030092.
• Compound A and compound B may have stereoisomers such as enantiomers and diastereomers, and in this specification, compound A and compound B refer to any of the above stereoisomers. or mixtures thereof in any proportion.
• Compounds selected from Group A include, for example, the following aspects.
• An embodiment wherein the compound selected from Group A is brofuranilide, nicofurprole, isocycloseram, or ciprofuranilide.
• An embodiment wherein the compound selected from Group A is brofuranilide.
• An embodiment wherein the compound selected from Group A is nicofluprole.
• An embodiment wherein the compound selected from Group A is isocycloceram.
• An embodiment wherein the compound selected from Group A is ciprofuranilide.
• An embodiment wherein the compound selected from Group A is brofuranilide or nicofurprole.
• An embodiment wherein the compound selected from Group A is isocycloseram or ciprofuranilide.
• An embodiment wherein the compound selected from Group A is brofuranilide, nicofurprole, or ciprofuranilide.
• An embodiment wherein the compound selected from Group A is brofuranilide, isocycloseram, or ciprofuranilide.
• Compound A is typically used as a control agent after being formulated by mixing with formulation auxiliaries.
• compound A which is an active ingredient, is mixed with an inert carrier and used as a composition (hereinafter referred to as composition X).
• composition X is typically prepared by mixing compound A with a suitable formulation adjuvant selected from the group consisting of solid carriers, liquid carriers, surfactants and the like, and if necessary, a binder.
• composition X usually contains 0.01 to 99.9% by weight, preferably 0.01 to 50% by weight, and more preferably 0.01 to 20% by weight of Compound A.
• Composition X includes, for example, aerosols (aerosols, pump sprays, ultrasonic vibration formulations, electrostatic spray formulations, etc.), poison bait agents, combustible agents (incense sticks, etc.), heat transpiration agents (electric mosquito repellent mats, liquid Mosquito repellent preparations, etc.), air-blowing transpiration agents (fan-type mosquito repellent preparations, etc.), fumigants (self-combustion fumigants, chemically reactive fumigants, porous ceramic plate fumigants, etc.), fumigants, fogging agents, ULV agents, mist agents, foam agents, paste formulations, paints, wood protection paints, sealants, carbon dioxide gas formulations, sheet formulations, tape formulations, paper formulations, non-woven fabric formulations, animal collars, animal ear tags, shampoos, Used after being processed into spot-on agents, pour-on agents, suppositories, injections, oral agents (capsules, tablets, chewable agents, feed, etc.), sublim
• the inert carrier may be an inert solid carrier or an inert liquid carrier.
• solid carriers include the following.
• Inorganics minerals (natural silicates, marble, pumice, limestone, rare earth minerals, cryolite, activated clay, lime, activated carbon, talc, attapulgite, sodium montmorillonite, calcium montmorillonite, kaolinite, calcite, dolomite, diatomite, bentonite, zeolite, sepiolite, pyrophyllite, vermiculite, crystalline silica, amorphous silica, etc.), silicon dioxide, calcium sulfate, magnesium sulfate, barium sulfate, magnesium oxide, aluminum oxide, ammonium sulfate, ammonium phosphate, ammonium nitrate, calcium phosphate , sulfur, calcium carbonate, sodium hydrogen carbonate, sodium carbonate, synthetic silicates, and pulverized products thereof;
• Organic matter Grain powders (rice bran, rice flour, corn powder, wheat flour, etc.), sugars (cellulose, starch
• Liquid carriers include, for example, water, aliphatic hydrocarbons (hexane, 1-hexene, cyclohexane, octane, isooctane, 1-heptene, d-limonene, pinene, hexadecane, etc.), aromatic hydrocarbons (alkylbenzenes (toluene, xylene , isopropylbenzene, p-diethylbenzene, etc.), alkylbenzene derivatives, alkylnaphthalene, alkylnaphthalene derivatives, tetrahydronaphthalene, etc.), chlorinated hydrocarbons (monochloroethylene, dichloroethylene, trichlorethylene, tetrachloroethylene, dichloromethane, 1,1,1-trichloroethane , 1,1,2-trichloroethane, 1,2-dichloropropane, etc.), ketones (cyclo
• solid carriers and liquid carriers may be used alone or in combination of two or more.
• surfactants examples include anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants.
• anionic surfactants include carboxylic acids, sulfonic acids, sulfate esters, and phosphoric esters, and specific examples are given below.
• Carboxylic acids fatty acid salts (octanoate, decanoate, laurate, myristate, palmitate, stearate, behenate, oleate, etc.), polyoxyethylene alkyl ether carboxylate (laureth -3-carboxylates, ⁇ -(carboxymethyl)- ⁇ -(dodecyloxy)poly(oxyethylene) salts, etc.), N-acylsarcosine salts (N-lauroylsarcosine salts, etc.), N-acylglutamates (N - lauroyl glutamate, etc.), polycarboxylates (polyacrylates, polyvinyl acetates, comb-shaped polymers of polyacid salts, etc.), derivatives thereof, etc.; Sulfonic acids: alky
• cationic surfactants include amine salts and quaternary ammonium salts, and specific examples are given below.
• Amine salts alkylamine salts (monomethylamine salt, dimethylamine salt, trimethylamine salt, etc.), fatty acid amidoamine salts (stearamidopropyldimethylamine, behenamidopropyldimethylamine, etc.), polyamine salts (polyvinylamine, polyethyleneimine, etc.), and derivatives thereof;
• Quaternary ammonium salts lauryltrimethylammonium salt, cetyltrimethylammonium salt, dodecyltrimethylammonium salt, stearyltrimethylammonium salt, benzalkonium chloride, benzethonium chloride, benzylbis(2-chloroethyl)ethylammonium bromide.
• amphoteric surfactants include betaine, alkylbetaine, alkyldimethylbetaine, imidazoline, taurine, alkyltaurine, dodecyldimethylammonioacetate, 4-carboxy-N,N,N-trimethyl-1-butanaminium, 1-carboxy-N,N,N-2-tetramethyl-1-propanaminium, N-alkyl (or alkenyl) (C12-18) glycine and its salts, N-dodecylglycine and its salts, and derivatives thereof is exemplified.
• nonionic surfactants include alcohols, amides, amines, esters, ethers, ether esters, and carboxylic acids, and specific examples include the following.
• Alcohols Aromatic alcohols (alkylphenols (allylphenol, octylphenol, nonylphenol, octylcresol, etc.), acylphenols, etc.), aliphatic alcohols (isotridecyl alcohol, oleyl alcohol, cetyl alcohol, etc.), polyhydric alcohols (polysaccharides, starch, starch derivatives, sucrose, alkyl polyglucosides, sorbitan, ethoxylated sorbitan, cellulose derivatives, gum arabic, etc.), synthetic polymers (polyvinyl alcohol, polyethylene glycol, etc.); Amides: alkanolamide (fatty acid alkanolamide (lauric acid diethanolamide, etc.), fatty acid glucamide (alkoxylated propylene oxide fatty acid
• these surfactants are not particularly limited, it is usually desirable to be in the range of 0.05 to 20 parts by weight per 100 parts by weight of the formulation. These surfactants may be used alone or in combination of two or more.
• control agents further include thickeners, protective colloid agents, antifreeze agents, antifoaming agents, antifungal agents, preservatives/bactericides, antioxidants, light stabilizers, pH adjusters, binders, and fixatives.
• the following formulation adjuvants arbitrarily selected from agents/spreading agents, lubricants/lubricating agents, anti-caking agents, fragrances, coating agents and inclusion agents may be used.
• thickeners examples include polysaccharides (xanthan gum, cellulose ester, cellulose ether, carboxymethylcellulose and its salts, dextrin, starch, guar gum, gum arabic, hydroxypropyl guar gum, tylose, carrageenan, etc.), clays (organic clay, organically modified clays, inorganic clays, inorganic modified clays, etc.), minerals (bentonite, attapulgite, silica, silicates, etc.), and synthetic polymers (polycarboxylates, polyacrylic acid derivatives, polyvinylpyrrolidone, polyvinyl alcohol, etc.). be done. These thickeners may be used alone or in combination of two or more.
• protective colloid agents examples include water-soluble celluloses such as methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose and carboxymethylcellulose, polyalkylene glycols such as polyethylene glycol and polypropylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, guar gum, and gum arabic. , gelatin, polyacrylate, alginate and the like. These protective colloid agents may be used alone or in combination of two or more.
• antifreezing agents examples include alcohols (ethylene glycol, propylene glycol, dipropylene glycol, triethylene glycol, ethylene glycol methyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, ethylene glycol butyl ether, glycerin, polyethylene glycol, etc.). , esters (dipropylene glycol dibenzoate, glycerol acetate, glycerol diacetate, glycerol triacetate, gamma-butyrolactone, etc.), ethers (1,4-dioxane, etc.), urea and the like. These antifreeze agents may be used alone or in combination of two or more.
• antifoaming agents examples include silicones (polysiloxane, diblock ethoxysiloxane, triblock ethoxysiloxane, etc.), alkylsulfosuccinates, higher alcohols, higher alcohol derivatives, fatty acid salts, fatty acid derivatives, and the like. . These antifoaming agents may be used alone or in combination of two or more.
• antifungal agents examples include benzothiazole derivatives, sorbic acid, potassium sorbate, and butyl p-hydroxybenzoate. These antifungal agents may be used alone or in combination of two or more.
• antiseptics/bactericides examples include phenols (orthophenylphenol, thymol, 3,5-dimethyl-4-chlorophenol, 2-isopropyl-5-methylphenol, 3-methyl-4-isopropylphenol, etc.), isothiazolinone derivatives (alkylisothiazolinone (5-chloro-2-methylisothiazolinone, 2-methylisothiazolinone, N-octylisothiazolinone, 4,5-dichloro-2-octyl-4-isothiazolin-3-one ), benzisothiazolinone (1,2-benzisothiazolinone, Nn-butylbenzisothiazolinone, etc.), bronopol derivatives (bronopol (2-bromo-2-nitropropane-1,3-diol), etc.) ), benzyl alcohol hemiformal, parabens (methylparaben, ethylparab
• antioxidants examples include phenols (2,6-di-t-butyl-p-cresol, 2,2′-methylenebis(4-methyl-6-t-butylphenol), etc.), amines (p, p'-dioctyldiphenylamine, N,N'-diphenyl-p-phenylenediamine, etc.), dibutylhydroxytoluene, butylhydroxyanisole, sodium erythorbate, sodium sulfite, potassium sulfite, potassium pyrosulfite, catechin, propyl gallate, sulfurs (didodecyl thiodipropionate, etc.), phosphoric acids (trisnonylphenyl phosphite, etc.), vitamins (alpha tocopherol, L-ascorbic acid, sodium ascorbate, ascorbyl palmitate, etc.) and the like. These antioxidants may be used alone or in combination of two or more.
• Light stabilizers include, for example, titanium oxide, zinc oxide, activated carbon, carbon black, ethylhexyl methoxycinnamate, tert-butylmethoxydibenzoylmethane, hindered amines, ferulic acid, phenyl hydroxybenzoate, ethyl para-aminobenzoate, salicylic acid.
• pH adjusters examples include sulfuric acid, nitric acid, hydrochloric acid, acetic acid, carbonic acid, oxalic acid, lactic acid, succinic acid, gluconic acid, citric acid, phosphoric acid, sorbic acid, salts thereof, sodium bicarbonate, and sodium hydroxide. , potassium hydroxide, calcium hydroxide, aluminum hydroxide, copper hydroxide, magnesium hydroxide and the like. These pH adjusters may be used alone or in combination of two or more.
• Binders include, for example, polysaccharides (xanthan gum, cellulose ester, cellulose ether, carboxymethylcellulose, hydroxypropyl guar gum, guar gum, natural gum arabic, synthetic gum arabic, dextrin, starch, carrageenan, etc.), clays (organic clay, organic modified clay, inorganic clay, inorganic modified clay, etc.), minerals (bentonite, etc.), synthetic polymers (polycarboxylic acid or its salts, polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol, polyacrylic acid or its salts, etc.), wax (plant fats, animal fats and their derivatives, paraffins, olefins, etc.). These binders may be used alone or in combination of two or more.
• the adhesive/spreading agent examples include the aforementioned surfactants, liquid carriers (esters (alkyl fatty acid ester, sorbitan fatty acid ester, ethoxylated fatty acid ester, ethoxysorbitan fatty acid, etc.), alcohols (ethoxylated fatty alcohol , ethoxylated sorbitan fatty alcohols, etc.), waxes (vegetable oils and fats, animal fats and their derivatives, paraffins, olefins, etc.), vegetable oils (alkylated vegetable oils, etc.), mineral oils (naphtha, etc.), silicone emulsions, synthetic Polymer (styrene-butadiene copolymer, methyl methacrylate-butadiene copolymer, polyacrylic acid or its salt, polyvinyl acetate, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol, polypropylene glycol, etc.), natural polymer (xant
• lubricants/lubricants examples include alcohols, fatty acid esters, sucrose fatty acid esters, glycerin fatty acid esters, hydrocarbons, paraffin, ethylene wax, and aliphatic Amides, erucamide, stearamide, oleamide, methylene bis stearamide, ethylene bis stearamide, metallic soaps, lead stearate, zinc stearate, calcium stearate, magnesium stearate, mineral oil, vegetable oil , kerosene, diesel oil, and the like. These lubricants and lubricants may be used alone or in combination of two or more.
• Anti-caking agents include, for example, the above solid carriers and liquid carriers, calcium phosphate, sodium phosphate, sodium carbonate, sodium silicate, calcium silicate, magnesium silicate, potassium aluminum silicate, silicon dioxide, talc, and aluminosilicate. Examples include sodium, calcium aluminosilicate, bentonite, stearic acid, dimethylpolysiloxane, and powdered cellulose. These anti-caking agents may be used alone or in combination of two or more.
• perfumes examples include hydrocarbons, ⁇ -limonene, ⁇ -caryophyllene, alcohols, cis-3-hexenol, linalool, farnesol, ⁇ -phenylethyl alcohol, aldehydes, 2,6-nonagenal, citral, ⁇ - hexyl cinnamic aldehyde, ketones, ⁇ -ionone, L-carvone, cyclopentadecanone, esters, linalyl acetate, benzyl benzoate, lactones, ⁇ -undecalactone, phenols, eugenol, oxides, rose oxide, Acetals, phenylacetaldehyde dimethylacetal, ⁇ -pinene, ⁇ -pinene and the like are exemplified. These perfumes may be used alone or in combination of two or more.
• Coating agents include, for example, natural rubber, synthetic rubber, resin (styrene-butadiene copolymer, polyacrylonitrile, polyester, polyamide, polyurethane, polyurea, polyether, rosin, melamine, etc.), wax (vegetable oil, animal oil, and these derivatives, paraffin, olefins, etc.), polysaccharides (xanthan gum, cellulose ester, cellulose ether, carboxymethyl cellulose or its salts, dextrin, starch, guar gum, gum arabic, hydroxypropyl guar gum, tylose, starch xanthate, carrageenan, etc.), proteins ( gelatin, etc.). These coating agents may be used alone or in combination of two or more.
• inclusion agents include cyclodextrins, ⁇ -cyclodextrin, ⁇ -cyclodextrin, ⁇ -cyclodextrin and the like. These clathrates may be used alone or in combination of two or more.
• Formulations containing compound A may further contain at least one of other commonly known insecticidally active compounds and synergists, said other insecticidally active compounds and synergists each comprising one It may be a species or two or more species.
• other commonly known insecticidally active compounds and synergists said other insecticidally active compounds and synergists each comprising one It may be a species or two or more species.
• alanycarb + SX means the combination of alanycarb and SX.
• the abbreviation SX means any one compound selected from compound A.
• all of the other insecticidally active compounds and synergists described below are known ingredients and can be obtained from commercial formulations or prepared by known methods.
• the numbers in parentheses represent CAS RN (registered trademark).
• the weight ratio of compound A to the sum of other insecticidal compounds and/or synergists is usually 0.01 to 100 parts by weight of other insecticidal compounds and synergists, preferably 1 part by weight of compound A. 0.02 to 50 parts by weight.
• the content of compound A in the control agent used in this control method is not limited, but is usually 0.01 to 99.9% by weight, preferably 0.01 to 50% by weight, more preferably 0.01 to 20% by weight.
• the control agent may be used as it is, or may be used after being diluted or suspended in water as appropriate.
• the amount used is preferably 0.0001 to 5000 ppm of the active ingredient, more preferably 0.01 to 1000 ppm.
• the control agent may be used by mixing with other insecticidal compounds, fungicides, synergists, etc. at the time of treatment, if necessary.
• Places where the aforementioned resistant arthropods are expected to appear and which can be controlled by the present control method include places where arthropod pests can pass through and places where arthropod pests can live.
• Specific examples of habitats of the arthropods exhibiting resistance or places where their appearance is predicted include houses, restaurants, commercial facilities, hospitals, stations, airports, factories, offices, schools, Examples include lodging facilities, waste disposal facilities, barns, warehouses, tents, vehicles, airplanes, ships, various products, the ground, forests, pastures, gutters, and the like. More specifically, wall surfaces, ceilings, floors, underfloors, pillars, transoms, windows, doors, pillars, transoms, windows, doors, etc. of places where the above-mentioned resistant harmful arthropods live or are expected to appear.
• cellulose component-containing materials thereof (wood products) and the like are exemplified.
• the treatment of the habitat of the above-mentioned resistant harmful arthropods or the place where the appearance thereof is expected is by spraying, coating, or transpiration of the control agent on the above-mentioned place, or by combining these. done in a way.
• Examples of materials for habitats of arthropods exhibiting resistance or where they are expected to appear include concrete (cement), bricks, bamboo, wood, tiles, ceramics, mud, metal, plastic, and thatch. , galvanized steel, etc., but are not limited to these.
• the active ingredient can be carried on the surface.
• the amount of the active ingredient to be carried may be appropriately adjusted according to the time of application, the place of application, the treatment method, etc.
• the amount of the active ingredient per 1 m 2 is usually 0.1 to 1000 mg, preferably 1 to 500 mg. , more preferably 5 to 300 mg.
• the term "harmful arthropods resistant to at least one insecticide selected from group B” means selected from the group consisting of fluxametamide, pyrethroid compounds, oxadiazine compounds, and phenylpyrazole compounds.
• "exhibiting resistance” means “decreasing susceptibility”. That is, arthropod pests that are resistant to at least one insecticide selected from the group consisting of fluxametamide, pyrethroid compounds, oxadiazine compounds, and phenylpyrazole compounds include fluxametamide, pyrethroid compounds, and oxadiazine.
• pyrethroid compounds are cypermethrin, alpha-cypermethrin, bifenthrin, cyfluthrin, beta-cyfluthrin, lambda cyhalothrin, deltamethrin, esfenvalerate, etofenprox, prallethrin, permethrin, and pyrethrin, and more preferably permethrin and deltamethrin. preferable.
• Indoxacarb is exemplified as the oxadiazine-based compound.
• phenylpyrazole compounds include ethiprole and fipronil, with fipronil being preferred.
• insecticides selected from Group B include the following aspects.
• An embodiment wherein the insecticide selected from Group B is fluxametamide, a pyrethroid compound, an oxadiazine compound, or a phenylpyrazole compound.
• An embodiment wherein the pyrethroid compound of Group B is at least one compound selected from the group consisting of permethrin, deltamethrin, cyhalothrin, cyfluthrin, cypermethrin, etofenprox, bifenthrin, and esfenvalerate.
• An embodiment wherein the oxadiazine-based compound of Group B is indoxacarb.
• phenylpyrazole-based compound of Group B is fipronil.
• insecticide selected from group B is fluxametamide.
• insecticide selected from Group B is a pyrethroid compound.
• insecticide selected from group B is permethrin.
• insecticide selected from group B is deltamethrin.
• insecticide selected from group B is permethrin or deltamethrin.
• pesticides selected from group B are permethrin and deltamethrin.
• insecticide selected from Group B is an oxadiazine compound.
• insecticide selected from Group B is indoxacarb.
• insecticide selected from Group B is a phenylpyrazole compound.
• insecticide selected from group B is permethrin or deltamethrin.
• pesticides selected from group B are permethrin and deltamethrin.
• insecticide selected from Group B is fipronil.
• insecticide selected from Group B is fluxametamide, a pyrethroid compound, indoxacarb, or fipronil.
• insecticide selected from Group B is fluxamethamide, permethrin, deltamethrin, indoxacarb, or fipronil.
• insecticide selected from Group B is fluxametamide, a pyrethroid compound, an oxadiazine compound, and a phenylpyrazole compound.
• insecticide selected from Group B is fluxametamide, pyrethroid compounds, indoxacarb, and fipronil.
• insecticide selected from Group B is fluxamethamide, permethrin, deltamethrin, indoxacarb, and fipronil.
• Ectobiidae such as Blattella germanica; Periplaneta fuliginosa, Periplaneta americana, Periplaneta australasiae, Periplaneta brunnea Blatta orientalis, Blatta lateralis, Supella longipalpa, etc.; Reticulitermes speratus, Coptotermes formosanus, Coptotermes gestroi , Incisitermes minor, Cryptotermes domesticus, Odontotermes formosanus, Neotermes koshunensis, Glyptotermes satsumensis, Glyptotermes nakajimai, Glyptotermes fuscus ), Hodotermopsis sjostedti, Coptotermes guangzhouensis, Reticulitermes amamianus, Reticulitermes miyatakei, Reticulitermes kanmonensis, Nasutitermes takasagoensis, Pericapri
• Siphonaptera Pulicidae, such as Pulex irritans, Ctenocephalides felis, Ctenocephalides canis, Xenopsylla cheopis, and Echidnophaga gallinacea; Hectopsyllidae, such as penetrans; Ceratophyllidae, such as the European rat flea (Nosopsyllus fasciatus).
• Psocodea Trogiidae, such as Trogium pulsatorium; Conachataceae (Liposcelidae or Liposcelididae).
• Thysanura Lepismatidae, such as Ctenolepisma villosa and Lepisma saccharina.
• Hymenoptera fire ants (Solenopsis invicta), red fire ants (Solenopsis geminata), southern fire ants (Solenopsis xyloni), black imported fire ants (Solenopsis richteri) and other Solenopsis spp., brown leaf cutting ants Atta capiguara, etc., Acromyrmex spp., Paraponera clavata, Ochetellus glaber, Monomorium pharaonis, Linepithema humile, Formica japonica), Myrtle ants (Pristomyrmex punctutus), Giant ants (Pheidole noda), Tsuya ant (Pheidole megacephala), Black carpenter ant (Camponotus japonicus), Breasted carpenter ant (Camponotus obscuripes), Black carpenter ant (Camponotus pennsylvanicus), Florida carpenter ant (
• Coleoptera Curculionidae such as Sitophilus zeamais, Sitophilus oryzae, Sitophilus granarius, etc.; Tribolium castaneum, Tribolium confusum, Tenebrionidae, such as Alphitobius diaperinus; Bostrychidae, such as Lyctus brunneus and Rhizopertha dominica; Ptinidae; Anoplophora malasiaca, Mig dolus Cerambycidae such as fryanus, Aromia bungii; Melanotus okinawensis, Agriotes fuscicollis, Melanotus legatus, Anchastus spp.
• Conoderus spp. Conoderus spp., Ctenicera spp., Limonius spp., Aeolus spp. Staphylinidae; Dermestidae such as Anthrenus verbasci, Dermestes maculates, and Trogoderma granarium; Lasioderma serricorne, Stegobium paniceum etc.
• Anobiidae such as Cryptolestes ferrugineus
• Laemophloeidae such as Cryptolestes ferrugineus
• Silvanidae such as Oryzaephilus surinamensis
• Nitidulidae Conoderus spp., Ctenicera spp., Limonius spp., Aeolus spp. Staphylinidae
• Dermestidae such as Anthrenus verbasci, Dermestes maculates, and Trogoderma granarium
• Lasioderma serricorne St
• Diptera Drosophilidae, such as Drosophila suzukii and Drosophila melanogaster; Phoridae, such as Megaselia spiracularis; Clogmia albipunctata, etc. Sciaridae, such as Bradysia difformis; Culex pipiens pallens, Culex tritaeniorhynchus, Culex pipiens f.
• Lepidoptera Tineidae, such as Tinea translucens and Tineola bisselliella.
• Hemiptera Cimicidae, such as Cimex lectularius and Cimex hemipterus; Cicadidae, such as Quesada gigas; Triatoma infestans, Triatoma rubrofasciata , Triatoma dimidiata, Triatoma sanguisuga, Kissing bug (Triatoma protracta), Venezuelan assassin bug (Rhodnius prolixus).
• Araneae Eutichuridae, such as Cheiracanthium japonicum; Theridiidae, such as Latrodectus hasseltii.
• Polydesmida Paradoxosomatidae, such as Oxidus gracilis and Nedyopus tambanus.
• Isopoda Armadillidiidae, such as Armadillidium vulgare.
• Chilopoda Scutigeridae, such as Thereuonema hilgendorfi; Scolopendridae, such as Scolopendra subspinipes; Ethopolyidae, such as Bothropolys rugosus.
• Embodiments of this control method include the following methods.
• the present control method, wherein the compound selected from Group A is isocycloceram.
• Aspect 10 The control method according to any one of aspects 1 to 9, wherein the insecticide selected from Group B is fluxametamide, a pyrethroid compound, an oxadiazine compound, or a phenylpyrazole compound.
• the pyrethroid compound of Group B is at least one compound selected from the group consisting of permethrin, deltamethrin, cyhalothrin, cyfluthrin, cypermethrin, etofenprox, bifenthrin, and esfenvalerate.
• the control method according to any one of the above.
• a part represents a weight part.
• Formulation example 1 A formulation is obtained by mixing 35 parts of a mixture of polyoxyethylene alkyl ether sulfate ammonium salt and silica (weight ratio 1:1), 10 parts of SX and 55 parts of water and finely pulverizing by wet grinding method.
• Formulation example 2 10 mg of SX and 0.5 mL of acetone are mixed, and the resulting mixture is added dropwise to 5 g of solid feed powder for animals (solid feed powder for breeding CE-2, product of CLEA Japan, Inc.) and mixed uniformly. The acetone is then evaporated to dryness to obtain the poison bait.
• Formulation example 3 A formulation is obtained by grinding and mixing 50 parts of SX, 3 parts of calcium lignosulfonate, 2 parts of sodium lauryl sulfate, and 45 parts of silica.
• Formulation example 4 A formulation is obtained by mixing 5 parts of SX, 9 parts of polyoxyethylene styrylphenyl ether, 5 parts of polyoxyethylene decyl ether (ethylene oxide addition number: 5), 6 parts of calcium dodecylbenzenesulfonate, and 75 parts of xylene.
• Formulation example 5 2 parts of SX, 1 part of silica, 2 parts of calcium lignosulfonate, 30 parts of bentonite, and 65 parts of kaolin clay are pulverized and mixed, kneaded with an appropriate amount of water, granulated with a granulator, and dried. to obtain the formulation.
• Formulation example 6 10 parts SX are mixed into a mixture of 18 parts benzyl alcohol and 9 parts DMSO, to which are added 6.3 parts GERONOL® TE250, 2.7 parts Ethylan NS-500LQ®, and 54 parts Solvent Naphtha. and mixed to obtain the formulation.
• Formulation example 7 The formulation is obtained by mixing 10 parts SX, 5 parts nonylphenol ethoxylate and 85 parts propylene glycol.
• Formulation example 8 The formulation is obtained by mixing 10 parts SX and 20 parts xylene and dispersing in 68 parts water containing 2 parts polyvinyl alcohol.
• Formulation example 9 30 parts of SX, 3 parts of calcium ligninsulfonate, 2 parts of sodium lauryl sulfate, and 65 parts of kaolin clay are pulverized and mixed, kneaded by adding an appropriate amount of water, granulated with a granulator, and dried. Obtain the formulation.
• Formulation example 10 35 parts of a mixture of polyoxyethylene alkyl ether sulfate ammonium salt and white carbon (weight ratio 1:1), 10 parts of SX, and 55 parts of water are mixed, and the resulting mixture is finely pulverized by a wet pulverization method. Granulation is performed using a granulator to obtain a formulation.
• Formulation Example 11 A formulation is obtained by mixing 20 parts SX, 5 parts polyoxyethylene nonylphenyl ether, 3 parts carboxymethylcellulose, and 72 parts water.
• Formulation Example 12 10 parts of SX, 0.2 parts of hexamethylene diisocyanate, and 10 parts of xylene are mixed and dispersed in 75.8 parts of water containing 2 parts of polyvinyl alcohol. A formulation is obtained by adding 2 parts of ethylenediamine and allowing the encapsulation reaction to proceed while mixing.
• Formulation Example 13 A formulation is obtained by grinding and mixing 2 parts of SX, 88 parts of kaolin clay, and 10 parts of talc.
• Formulation Example 14 SX 60 parts, special aromatic sodium sulfonate sodium formalin condensate (trade name: Demoll SN-B, manufactured by Kao Corporation) 10 parts, sodium lauryl sulfate (trade name: Emal 10 powder, manufactured by Kao Corporation) 4 parts and After mixing 26 parts of kaolin-based clay (trade name: A clay, manufactured by Katsukozan Mining Co., Ltd.), the mixture is pulverized with an air mill. Next, 11 parts of water is added to the pulverized product and kneaded well. The obtained kneaded product is granulated with a small extrusion granulator equipped with a 0.7 mm ⁇ screen, dried at 60°C for 10 minutes, and granulated. By doing so, a granular wettable powder is obtained.
• kaolin-based clay trade name: A clay, manufactured by Katsukozan Mining Co., Ltd.
• Formulation example 15 50 parts SX, 3.0 parts sodium diisopropylnaphthalene sulfonate, 4.0 parts sodium sulfomethylated lignin sulfonate, 0.25 parts cellulose carboxymethyl ether sodium salt, 1.0 parts amorphous silica, and 41.75 parts lactose are mixed and pulverized with an air mill. Next, 10 parts of water is added to the pulverized product and kneaded, and the obtained kneaded product is granulated with a small extrusion granulator equipped with a 1.0 mm ⁇ screen, dried at 60°C for 10 minutes, and granulated. A granular wettable powder is thus obtained.
• Formulation Example 16 SX 43.4 parts, silicone antifoaming agent (trade name: Xiameter ACP-1500 Antifoam compound, manufactured by Dow Corning Toray Co., Ltd.) 0.2 parts, polyoxyethylene tristyrylphenyl ether phosphate triethanolamine salt (trade name: 3.4 parts of Soprofol FL (manufactured by Solvey), 4.3 parts of propylene glycol and 20.5 parts of ion-exchanged water are mixed and wet pulverized in a bead mill to obtain a suspension.
• silicone antifoaming agent trade name: Xiameter ACP-1500 Antifoam compound, manufactured by Dow Corning Toray Co., Ltd.
• polyoxyethylene tristyrylphenyl ether phosphate triethanolamine salt trade name: 3.4 parts of Soprofol FL (manufactured by Solvey)
• Formulation Example 17 SX 40 parts, sodium ligninsulfonate (trade name: Reax 85A, manufactured by Ingevity, weight average molecular weight 10000, degree of sulfonation 0.8) 5 parts, silicone antifoaming agent (trade name: Xiameter ACP-1500 Antifoam compound, Toray ⁇ Dow Corning) 0.5 parts, 5 parts of propylene glycol, silica (trade name: Aerosil COK-84, manufactured by Evonik) 1 part and 48.3 parts of ion-exchanged water After mixing, horizontal bead mill (trade name) : DYNO-MILL KDL, WILLY A. BACHOFEN AG, manufactured by Maschinenfabrik) to obtain a suspension.
• sodium ligninsulfonate trade name: Reax 85A, manufactured by Ingevity, weight average molecular weight 10000, degree of sulfonation 0.8
• silicone antifoaming agent trade name: Xiameter ACP-1500 Antif
• Test example 1 An acetone solution containing each of permethrin, deltamethrin, fipronil, indoxacarb, fluxamethamide, brofuranilide, nicofurprole, ciprofuranilide, or isocycloseram at a predetermined concentration was prepared, and 1 ⁇ L of the acetone solution was applied to the thoracic ventral surface of male adult German cockroaches. . Two strains of the German cockroach were used: the German cockroach that is susceptible to insecticides and the German cockroach that is resistant to a plurality of insecticides.
• Insecticide-resistant German cockroaches show high resistance to pyrethroids, phenylpyrazoles, and oxadiazines.
• a strain with A302S mutation in the GABAergic chloride channel that confers resistance and enhanced detoxification metabolic activity.
• the application concentration is 3 or more concentrations that give a mortality rate of 0 to 100% (however, the concentration that gives a mortality rate of less than 50% is 1 or more, and the concentration that gives a mortality rate of over 50% is 1 or more), per concentration
• the number of test individuals was 2 replicates of 10 animals. Four days later, the number of dead German cockroaches was investigated, and the LD50 value was determined by the Probit method.
• Mortality rates of 0% and 100% were corrected by Miller and Tainter's correction in the following formula (1), and the post-correction mortality rate was used to determine the LD50 value.
• the resistivity ratio was calculated by the following formula (2).
• a dead individual refers to an individual whose behavior has completely stopped.
• Table 1 shows the LD50 values obtained from the tests.
• Resistance ratio LD50 value of resistant strain/ LD50 value of susceptible strain
• brofuranilide, nicofurprole, ciprofuranilide, and isocycloseram can effectively control arthropod pests that are highly resistant to permethrin, deltamethrin, fipronil, indoxacarb, and fluxametamide, respectively. was done.

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