WO2023100691A1 - 幹細胞増殖促進剤 - Google Patents

幹細胞増殖促進剤 Download PDF

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Publication number
WO2023100691A1
WO2023100691A1 PCT/JP2022/042858 JP2022042858W WO2023100691A1 WO 2023100691 A1 WO2023100691 A1 WO 2023100691A1 JP 2022042858 W JP2022042858 W JP 2022042858W WO 2023100691 A1 WO2023100691 A1 WO 2023100691A1
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WIPO (PCT)
Prior art keywords
heparanase
mmp
inhibitor
seaweed extract
imidazolidinone
Prior art date
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Ceased
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PCT/JP2022/042858
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English (en)
French (fr)
Japanese (ja)
Inventor
俊介 入山
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Shiseido Co Ltd
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Shiseido Co Ltd
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Publication date
Application filed by Shiseido Co Ltd filed Critical Shiseido Co Ltd
Priority to CN202280073400.8A priority Critical patent/CN118202039A/zh
Priority to US18/706,991 priority patent/US20250041189A1/en
Priority to JP2023564886A priority patent/JPWO2023100691A1/ja
Priority to EP22901124.2A priority patent/EP4442811A4/en
Publication of WO2023100691A1 publication Critical patent/WO2023100691A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/04—Rhodophycota or rhodophyta (red algae), e.g. Porphyra
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/76—Undefined extracts from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/73—Hydrolases (EC 3.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/73—Hydrolases (EC 3.)
    • C12N2501/734—Proteases (EC 3.4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

Definitions

  • the epidermal stem cell proliferation-promoting agent is a heparanase/MMP-9 inhibitor such as 1-(2-hydroxyethyl)-2-imidazolidinone, and a seaweed extract such as Algerex. It can also be expressed as a composition for use in promoting proliferation of epidermal stem cells containing Such compositions may be used in particular for non-therapeutic cosmetic applications.
  • one aspect of the present disclosure is a heparanase/MMP-9 inhibitor, such as 1-(2-hydroxyethyl)-2-imidazolidinone, and Algerex, etc., in promoting proliferation of epidermal stem cells. of seaweed extracts.
  • barrier function-improving agent skin barrier recovery promoting agent
  • a barrier function-improving agent skin barrier recovery promoting agent
  • a heparanase/MMP-9 inhibitor and a seaweed extract as active ingredients.
  • barrier function-improving agents comprise a combination of 1-(2-hydroxyethyl)-2-imidazolidinone and Algelex.
  • heparanase/MMP-9 inhibitors include 1-(2-hydroxyethyl)-2-imidazolidinone and derivatives thereof, particularly heparanase, which have a heparanase activity inhibitory effect/MMP-9 inhibitory effect. Those having both an activity inhibitory effect and an MMP-9 inhibitory effect can be preferably used.
  • the agent according to the present disclosure may contain only one type of 1-(2-hydroxyethyl)-2-imidazolidinone or a derivative thereof, but any combination of two or more of the above compounds or salts thereof and ratios.
  • the agent according to the present disclosure may contain only one type of seaweed extract such as Algerex, but may contain two or more types of seaweed extracts in any combination and ratio.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Microbiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)
PCT/JP2022/042858 2021-12-03 2022-11-18 幹細胞増殖促進剤 Ceased WO2023100691A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN202280073400.8A CN118202039A (zh) 2021-12-03 2022-11-18 干细胞增殖促进剂
US18/706,991 US20250041189A1 (en) 2021-12-03 2022-11-18 Stem cell proliferation promoter
JP2023564886A JPWO2023100691A1 (https=) 2021-12-03 2022-11-18
EP22901124.2A EP4442811A4 (en) 2021-12-03 2022-11-18 STEM CELL PROLIFERATION PROMOTER

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2021-196698 2021-12-03
JP2021196698 2021-12-03

Publications (1)

Publication Number Publication Date
WO2023100691A1 true WO2023100691A1 (ja) 2023-06-08

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PCT/JP2022/042858 Ceased WO2023100691A1 (ja) 2021-12-03 2022-11-18 幹細胞増殖促進剤

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US (1) US20250041189A1 (https=)
EP (1) EP4442811A4 (https=)
JP (1) JPWO2023100691A1 (https=)
CN (1) CN118202039A (https=)
WO (1) WO2023100691A1 (https=)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007204449A (ja) * 2006-02-03 2007-08-16 Pias Arise Kk マトリックスメタロプロテアーゼ−９及びエンドセリン−１の産生抑制剤、並びにその産生抑制剤を配合した炎症後色素沈着の予防・改善剤、化粧料
JP2013510147A (ja) * 2009-11-09 2013-03-21 エイボン プロダクツ インコーポレーテッド 睫毛強化用組成物及びその方法
JP2014165586A (ja) 2013-02-22 2014-09-08 Fuji Xerox Co Ltd 通信情報計測装置及びプログラム
WO2018074606A1 (ja) * 2016-10-21 2018-04-26 株式会社資生堂 ラミニン５１１産生促進剤、表皮基底膜安定化剤及び／又は表皮幹細胞減少抑制又は増加促進剤のスクリーニング方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007204449A (ja) * 2006-02-03 2007-08-16 Pias Arise Kk マトリックスメタロプロテアーゼ−９及びエンドセリン−１の産生抑制剤、並びにその産生抑制剤を配合した炎症後色素沈着の予防・改善剤、化粧料
JP2013510147A (ja) * 2009-11-09 2013-03-21 エイボン プロダクツ インコーポレーテッド 睫毛強化用組成物及びその方法
JP2014165586A (ja) 2013-02-22 2014-09-08 Fuji Xerox Co Ltd 通信情報計測装置及びプログラム
WO2018074606A1 (ja) * 2016-10-21 2018-04-26 株式会社資生堂 ラミニン５１１産生促進剤、表皮基底膜安定化剤及び／又は表皮幹細胞減少抑制又は増加促進剤のスクリーニング方法

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHEN YANHUI, CHEN YING, HUANG LIYONG, YU JIANBIN: "Evaluation of heparanase and matrix metalloproteinase-9 in patients with cutaneous malignant melanoma", JOURNAL OF DERMATOLOGY, JAPANESE DERMATOLOGICAL ASSOCIATION, TOKYO., JP, vol. 39, no. 4, 1 April 2012 (2012-04-01), JP , pages 339 - 343, XP093069914, ISSN: 0385-2407, DOI: 10.1111/j.1346-8138.2011.01441.x *
FARHAD BEHZADPAUL E C BRENCHLEY: "A multiwell format assay for heparinase", ANAL. BIOCHEM., vol. 320, no. 2, 15 September 2003 (2003-09-15), pages 207 - 13, XP004447147, DOI: 10.1016/S0003-2697(03)00358-0
IRIYAMA SYAMANISHI HKUNIZAWA NHIRAO TAMANO S.: "1-(2-Hydroxyethyl)-2-imidazolidinone, a heparanase and matrix metalloproteinase inhibitor, improves epidermal basement membrane structure and epidermal barrier function", EXPERIMENTAL DERMATOLOGY, vol. 28, no. 3, 2019, pages 247 - 53, XP055688084, DOI: 10.1111/exd.13876
IRIYAMA SYASUDA MNISHIKAWA STAKAI EHOSOI JAMANO S.: "Decrease of laminin-511 in the basement membrane due to photoaging reduces epidermal stem/progenitor cells", SCIENTIFIC REPORTS, vol. 10, no. 1, 2020, pages 12592
MACPHERSON LJBAYBURT EKCAPPARELLI MPCARROLL BJGOLDSTEIN RJUSTICE MR ET AL.: "Discovery of CGS 27023A, a non-peptidic, potent and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 16, 1997, pages 2525 - 32, XP002942148, DOI: 10.1021/jm960871c
PAN WMIAO HQXU YJNAVARRO ECTONRA JRCORCORAN E ET AL.: "1-[4-(1H-Benzoimidazol-2-yl)-phenyl]-3-[4-(1H-benzoimidazol-2-yl)-phenyl]-urea derivatives as small molecule heparanase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 2, 2006, pages 409 - 12, XP025106541, DOI: 10.1016/j.bmcl.2005.09.069
See also references of EP4442811A4

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EP4442811A1 (en) 2024-10-09
US20250041189A1 (en) 2025-02-06
CN118202039A (zh) 2024-06-14
JPWO2023100691A1 (https=) 2023-06-08
EP4442811A4 (en) 2025-03-12

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