WO2023057556A1 - Composition pour réduire la concentration de virus et du virus de la peste porcine africaine (african swine fever, asfv) dans des aliments pour animaux et matériaux de litière pour étables - Google Patents

Composition pour réduire la concentration de virus et du virus de la peste porcine africaine (african swine fever, asfv) dans des aliments pour animaux et matériaux de litière pour étables Download PDF

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Publication number
WO2023057556A1
WO2023057556A1 PCT/EP2022/077791 EP2022077791W WO2023057556A1 WO 2023057556 A1 WO2023057556 A1 WO 2023057556A1 EP 2022077791 W EP2022077791 W EP 2022077791W WO 2023057556 A1 WO2023057556 A1 WO 2023057556A1
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Prior art keywords
feed
composition
acid
asfv
use according
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PCT/EP2022/077791
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German (de)
English (en)
Inventor
Bernhard ECKEL
Viktor ECKEL
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Dr. Eckel Vermögensverwaltung Gmbh
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Priority claimed from EP22186737.7A external-priority patent/EP4176730A1/fr
Application filed by Dr. Eckel Vermögensverwaltung Gmbh filed Critical Dr. Eckel Vermögensverwaltung Gmbh
Publication of WO2023057556A1 publication Critical patent/WO2023057556A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A23K10/33—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from molasses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
    • A23K10/38—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material from distillers' or brewers' waste
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/28—Silicates, e.g. perlites, zeolites or bentonites

Definitions

  • composition for reducing the concentration of viruses and African Swine Fever Virus (ASFV) in animal feed and bedding for stables
  • the present invention relates to the use of a composition comprising inflorescences and/or one or more extracts of female inflorescences of the genus Humulus and/or one or more extracts of glycyrrhiza and/or one or more plant parts of glycyrrhiza for reducing the concentration of viruses and in particular the African one African Swine Fever Virus (ASFV) in animal feed and in bedding material ("litter”) for stables (such as straw and/or straw pellets).
  • ASFV African one African Swine Fever Virus
  • the composition can also have other components, in particular one or more acids such as formic acid, acetic acid, lactic acid, propionic acid, butyric acid, fumaric acid, malic acid, tartaric acid and/or citric acid and/or their ammonium, sodium, potassium, calcium and /or magnesium salts and/or one or more components selected from the group consisting of grape pomace, grape seed extract, grape seeds, acacia exudate, Quillaya saponaria, diatomaceous earth, soap bark extract, grapevine extract, 1,2-propanediol, roselle, Sapindus sapinoria, carrier E551 and flow aids and in particular contain any combination of the above components.
  • acids such as formic acid, acetic acid, lactic acid, propionic acid, butyric acid, fumaric acid, malic acid, tartaric acid and/or citric acid and/or their ammonium, sodium, potassium, calcium and /or magnesium salts and/or one or more components selected from the group consist
  • viruses can be found in all types of living beings as obligate cell-bound microorganisms and pathogens. Poison means virus in Latin. According to Büttner (2006), viruses can only reproduce in living cells. Known viruses in pig production include Porcine Epidenic Diarrhea Virus (PEDV), Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Seneca Valley A Virus (SVA) and ASFV.
  • PEDV Porcine Epidenic Diarrhea Virus
  • PRRSV Porcine Reproductive and Respiratory Syndrome Virus
  • SVA Seneca Valley A Virus
  • ASFV ASFV
  • ASFV African Swine Fever
  • the invention presented thus contributes to containing the African swine fever virus and thus improves biosecurity in agricultural production.
  • the outbreak of ASF is having a significant impact on global protein supply with a negative impact on pork production and consumption (Woonwong et al., 2020: The future of the pig industry after the introduction of African Swine Fever into Asia; Animal Frontiere; Vol. 10, No. 4).
  • African swine fever is a highly contagious, generalized disease of pigs caused by an iridovirus of the Asfarviridae family.
  • viruses have different virulence depending on the strain. They are also distinguished by a very high resistance to physical and/or chemical inactivation.
  • the pathogen can remain viable in blood, faeces and tissues for a long time. It can also spread through other vectors (including bedding materials and empty livestock transport vehicles returning from affected areas). Therefore, control of ASF depends on eradication policies and strict enforcement of sanitation plans.
  • ASF most commonly occurs in the acute form as hemorrhagic fever.
  • the ASF virus itself is a double-stranded DNA arbovirus. At the same time, it is the only member of the Asfarviridae family.
  • Pigs belong to the even-toed ungulates and here to the suborder of the pig-like (Suina).
  • the following genera are included: Sus (wild boar), Babyrousa (babies), Phacochoerus (warthogs) and Potamochoerus (bush pigs and river hogs) [cf. also Systematic Zoology, Volker Storch, Ulrich Welsch; Spectrum Academic Publishing House, October 21, 2003 - p. 854],
  • Feed is the basis of animal husbandry - this applies equally to agricultural livestock farming and the downstream food industry, as well as to the keeping of pets and hobby animals (key data of the feed industry - Deutscher Verband Tiernahrung e.V. (dvtiernahrung.de))
  • (animal) feed can be understood as a single feed, a combination of single feeds, premixes thereof and/or other active ingredients and complete feed(s).
  • bedding material is also a vector for the transmission of viruses and in particular ASF.
  • bedding material can be understood as straw, straw pellets or other organic, low-dust materials (see: Guidelines for species-appropriate pig husbandry: here NEULAND guidelines for species-appropriate pig husbandry; as of April 2018). Since bedding materials are produced in a similar way to animal feed, or are a by-product of their production, it must be assumed that bedding materials play a similar role in the transmission of ASF. This applies in particular since these are stored under the same conditions and come into intensive contact with the animal. According to the invention, the litter material is treated according to the dosages for feed before being littered.
  • WO2022/112365A1 describes a method for shortening the retention time required to ensure virus degradation in the feed.
  • the virucidal effect of benzoic acid in animal feed can be enhanced by essential oils.
  • One embodiment of the invention relates to a method for at least partially inactivating ASFV in pig feed, characterized in that benzoic acid is added to the pig feed together with at least one essential oil.
  • the preferred essential oils are thymol and eugenol.
  • WO 2020/149892 A1 describes a method of using the feed additive based on formaldehyde and propionic acid described there to reduce ASF in cell culture tests and feed.
  • PEDV Porcine Epidenic Diarrhea Virus
  • PRRSV Porcine Reproductive and Respiratory Syndrome Virus
  • SVA Seneca Valley A Virus
  • Trudeau et al., 2016 (Trudeau et al., 2016; Comparison of Thermal and Non-Thermal Processing for Swine Feed and the Use of Selected Feed additives on Inactivation of PEDV, Published: June 24, 2016) also describe that future research are required to determine the prevalence and maximum titers of PEDV in commercial pig feedstuffs, to determine the treatment parameters (time and temperature of thermal treatment and dose of eBeam treatment (Applications of ionizing radiation technology (ebeam)) and feed additive chosen), most effective for inactivating PEDV.
  • eBeam treatment Applications of ionizing radiation technology (ebeam)
  • feed additive chosen most effective for inactivating PEDV.
  • WO 2020/180877 A1 and Trudeau et al., 2016 make no reference to ASFV.
  • Patent EP 3054783 B1 describes a composition of medium-chain fatty acids and a feed supplement containing this composition.
  • the invention is disclosed to improve gut health and immunity in animals and eliminate harmful pathogens.
  • the composition as described there contains additional raw materials (additives) and/or growth-promoting substances.
  • the additives are selected from the group consisting of flavors, plant extracts and carboxylic acids, among others. Claims 5 and 6 disclose that the formulation is also effective against viruses, specifically norovirus and rotavirus. However, the flavors, plant extracts and carboxylic acids are not further mentioned in the claims.
  • the publication CN110279033A relates to a method for producing a feed additive from hop extract.
  • the Humulus lupulus extract supplement is made up of the following components, in parts by weight: 20-50 parts Humulus lupulus extract, 20-30 parts licorice powder, and 20-60 parts corn cob meal.
  • 20-50 parts Humulus lupulus extract 20-30 parts licorice powder
  • 20-60 parts corn cob meal 20-60 parts corn cob meal.
  • the publication CN110664914A describes a method based in particular on fermentation according to Chinese medicine to reduce ASFV.
  • the plants to be fermented (substrate) and the microorganisms (yeast, lactic acid bacteria and Bacillus subtilis) that are relevant to the process are described explicitly. Due to the fermentation and the described procedure and focus on fermentation, however, it can be assumed that the described effect is based on the fermentation of the substrate itself.
  • CN110651903A a method is described, a pig feed based on wormwood, to reduce ASFV.
  • herbs, vitamins and enzymes, acids are explicitly used only for acidification.
  • CN111213786A and CN109497107A describe methods through drinking water application and a method for disinfecting airborne diseases such as ASF. Both methods are therefore not applicable to fodder and bedding materials.
  • compositions known from the prior art are not satisfactory in every respect.
  • One object of the present invention is therefore to provide compositions or combinations which bring about a reduction in the concentration of viruses, in particular ASFV, in animal feed, preferably in feed for pigs.
  • the present invention also helps to sustainably reduce the viral load in bedding material, in particular based on straw, straw pellets or other organic, low-dust materials.
  • the inventors were able to show that the amount of viruses, in particular ASFV, in animal feed was significantly reduced, in particular by use according to the invention.
  • FIG. 1 shows the determination of the ASFV kinetics after virus inoculation of the feed rtPCR (Ct values >40 negative; ⁇ 40 positive).
  • FIG. 2 shows the determination of the ASFV kinetics after virus inoculation by means of rtPCR (Ct values >40 negative; ⁇ 40 positive).
  • FIG. 3 shows the determination of the ASFV kinetics after virus inoculation using HAD50.
  • FIG. 4 shows the determination of the ASFV kinetics after virus inoculation using HAD50.
  • FIG. 5 shows that the substances according to the invention achieve an increased effect either additively or multiplicatively.
  • the invention relates comprehensively to the use of a composition
  • extracts of glycyrrhiza and/or one or more plant parts of glycyrrhiza preferably from roots, root suckers and/or rootstock, to reduce viruses (or their concentration) in litter materials, and/or viruses (or their concentration) in feed, preferably animal feed, preferably the ASF virus (or its concentration) in bedding materials, and/or the ASF virus (or its concentration) in feed, preferably animal feed.
  • extracts of female inflorescences of the genus Humulus refer in particular to the total soft resins of the hops, isomerized or not.
  • alpha acid extracts from hops and their isomerized iso-alpha acids include alpha acids and their isomers include humulone, cohumulone and adhumulone and isohumulone, isocohumulone and isoadhumulone), as free as possible of beta acids and hop oils.
  • Hop extracts also include beta acid extracts (if possible free from alpha acids and hop oils) of hops and their isomerized iso-beta acids.
  • the ß-acids include lupulone, colupulone and adlupulone.
  • synthetic alpha and beta acids or their isomerized forms as well as hop cone pellets, hop cone powder and the extraction grains of the hop preferably comprise component (i) according to the invention.
  • extracts of glycyrrhiza refers in particular to the use of dry, water-soluble and/or liquid liquorice extract and/or liquorice powder.
  • the total amount of (i) inflorescences and/or extracts of female inflorescences of the genus Humulus and/or (ii) extracts of glycyrrhiza and/or plant parts of glycyrrhiza is at least 20% by weight of the composition, based on the total weight of the composition;
  • the ratio, preferably the weight ratio, of (i) inflorescences and/or extracts of female inflorescences of the genus Humulus and/or (ii) extracts of glycyrrhiza and/or plant parts of glycyrrhiza is between 0.5 and 3.5, more preferably between 0.6 and 3.3 and most preferably between 0.7 and 3.0; and or
  • the dosage in the fodder or organic litter based on the total amount of dry matter of the fodder, is 0.01% to 0.15% by weight and preferably 0.03% to 0.12% by weight, and more preferably 0.04% to 0.10% by weight; and or
  • the total dosage of the composition from (i), (ii), (iii) and/or (iv) is between 0.1% by weight to 1.5% by weight, preferably 0.3% by weight to 1.0% by weight and more preferably 0.4% by weight to 0.8% by weight, based on the total weight of the dry matter of the feed or organic litter; and or
  • the composition contains between 1.5% by weight and 12% by weight, preferably between 2% by weight and 11% by weight or between 3% by weight and 10% by weight, of the components (i ) and (ii) based on the total weight of the composition.
  • litter material and “litter” can be used synonymously.
  • the invention relates to a corresponding composition as such.
  • the components according to the invention can each be used individually or in combination with one another. These substances achieve an increased effect either additively or multiplicatively (see also FIG. 5).
  • the components, in particular the extracts can be liquid or solid and either contain residues of the extraction agent or not. According to the invention, these extracts can be either liquid or solid and can be natural, nature-identical or synthetic.
  • 1,2-propanediol propylene glycol
  • Application in the feed materials, premixes and complete feeds is carried out by mixing into the animal feed and litter materials or by spraying the liquid components according to the invention into the animal feed and litter materials during the mixing process or by application after mixing and/or pelleting and/or granulating.
  • the administration according to the invention preferably takes place in the event of an increased risk of ASFV and particularly preferably continuously.
  • components (i) and/or (ii) are administered individually or in combination, particularly preferably in a combination preparation with components (iii) and/or (iv), to the individual feeds, premixes and complete feeds and litter materials.
  • components (i) and/or (ii) and/or (iii) and/or (iv) are used in the form of a premix, preferably in the form of a premixed composition, in each case component (i) or (ii) or (iii) or (iv) alone, preferably at least two of the components (i) and/or (ii) and/or (iii) and/or (iv, particularly preferably the components (i) and (ii) administered, preferably by be admixed to the single feeds, premixes and complete feeds and litter materials.
  • components (i), (ii), (iii) or (iv) can each be administered alone.
  • Components (i), (ii), (iii) are particularly preferred ) and/or (iv) but administered together /or be administered firmly.
  • composition does not contain corn cob meal.
  • Example 1 Some typical compositions of an animal feed additive mixture are listed below as examples of the composition according to the invention, the details being given in percentages by weight based on the total weight of the composition.
  • Example 1 Some typical compositions of an animal feed additive mixture are listed below as examples of the composition according to the invention, the details being given in percentages by weight based on the total weight of the composition.
  • Example 1 Some typical compositions of an animal feed additive mixture are listed below as examples of the composition according to the invention, the details being given in percentages by weight based on the total weight of the composition.
  • Example 13 Example 14:
  • This pig feed was free of antibiotics and formaldehyde.
  • Components included grains, soy, grain by-products, meat and bone meal, vitamins and minerals.
  • strain VNUA/HY-ASF1/Vietnam/2019 was used to inoculate feed.
  • the virus isolate was taken from the collection of the Department of Microbiology and Infectious Disease, Key Laboratory for Veterinary Biotechnology, Vietnam National University of Agriculture (VNUA). It belongs to the p72 genotype II, which is 100% identical to the highly pathogenic ASFV strain isolated in China (2018) and Georgia (2007).
  • the vaccination density of ASFV was 10 8 HAD50/ml.
  • Porcine macrophages (either BMDM, bone marrow-derived macrophages or PAM, porcine alveolar macrophages) were obtained from pigs using RPMI medium one day before the experiment.
  • the BMDM/PAM cells were collected, washed and cultured in 96-well plates at 100 ⁇ l cells/well.
  • the freedom of the pig feed, components and reagents from ASFV was ensured by rtPCR. In each case 100 g of pig feed were aliquoted. The samples were then treated with the components of the invention.
  • ASFV VNUA/HY-ASF1/Vietnam/2019
  • VNUA/HY-ASF1/Vietnam/2019 solution 10 8 HADso/ml
  • the formulations were used, each related to 5400 g / ton application in the feed.
  • the components used were extracts from female inflorescences of the genus Humulus, in particular total soft resins and hop husks, (ii) extracts of glycyrrhiza (iii) E551 and (iv) citric acid and the calcium salts of formic and lactic acid in a ratio of 15:70:13.
  • all components were listed in the European feed legislation, as of 2021.
  • the haemadsorption assay showed that component B significantly reduced the activity of ASFV in the feed from day 1 to 7 ( Figures 3 and 4).
  • AF African Swine Fever Virus
  • the reduction in the concentration of viruses and/or the African swine fever virus (ASFV) here means in particular the reduction in the concentration of one virus or several viruses selected from the group consisting of porcine epidenic diarrhea virus (PEDV), porcine reproductive and respiratory syndrome Virus (PRRSV), Seneca Valley A Virus (SVA) and ASFV understood, preferably African Swine Fever Virus (ASFV) understood.
  • PEDV porcine epidenic diarrhea virus
  • PRRSV porcine reproductive and respiratory syndrome Virus
  • SVA Seneca Valley A Virus
  • ASFV understood, preferably African Swine Fever Virus (ASFV) understood.
  • AF1 Use of an alpha acid extract or synthetic alpha acid from hops and their isomerized iso-alpha acids (the alpha acids and their isomers include humulone, cohumulone and adhumulone and isohumulone, isocohumulone and isoadhumulone), as free as possible of beta acids and hop oils for (i) reducing the concentration of viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding, or (ii) inactivating viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding.
  • ASFV African swine fever virus
  • ASFV African swine fever virus
  • AF2 Use of a beta acid extract or synthetic beta acid (preferably free from alpha acids and hop oils) of hops to (i) reduce the concentration of viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding material, or (ii) inactivate viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding.
  • the ß-acids include lupulone, colupulone and adlupulone.
  • AF3 Use of a hop aroma extract (if possible free of hop acids) to (i) reduce the concentration of viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding material, or (ii) inactivate viruses and/or des African swine fever virus (ASFV) in animal feed and organic bedding.
  • a hop aroma extract if possible free of hop acids
  • AF4 Use of other extracts of hops to (i) reduce the concentration of viruses and/or reduce the concentration of African swine fever virus (ASFV) in animal feed and organic bedding material or (ii) inactivate viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding material.
  • ASFV African swine fever virus
  • AF6 Use of hop cone powder to (i) reduce levels of viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding, or (ii) inactivate viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding material.
  • ASFV African swine fever virus
  • AF7 Use of a combination of AF 1-6 to (i) reduce levels of viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding, or (ii) inactivate viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding material.
  • ASFV African swine fever virus
  • AF9 Use of licorice powder to (i) reduce levels of virus and/or African swine fever virus (ASFV) in animal feed and organic bedding, or (ii) inactivate virus and/or African swine fever virus (ASFV) in animal feed and organic bedding material.
  • AF10 Use of a combination of AF 8 and 9 to (i) reduce levels of virus and/or African swine fever virus (ASFV) in animal feed and organic bedding, or (ii) inactivate virus and/or African swine fever virus Virus (ASFV) in animal feed and organic bedding material.
  • ASFV African swine fever virus
  • AF11 Using a combination of one of the AF 1-7 and one of the AF 8-10 for
  • AF12 Use of one or more extracts and/or components of at least one plant selected from group (iii) consisting of grape marc, grape seed extract, grape seed, acacia exudate, Quillaya saponaria, soap bark extract, grapevine extract, roselle, Sapindus sapinoria, kieselguhr, E551 (a-c) and 1,2-propanediol, for (i) reducing the concentration of viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding material, or (ii) inactivating viruses and/or African swine fever virus (ASFV ) in animal feed and organic bedding material.
  • group (iii) consisting of grape marc, grape seed extract, grape seed, acacia exudate, Quillaya saponaria, soap bark extract, grapevine extract, roselle, Sapindus sapinoria, kieselguhr, E551 (a-c) and 1,2-propanediol, for (i)
  • AF13 Use of one or more of the following acids and their salts: (iv) formic acid, acetic acid, lactic acid, propionic acid, butyric acid, fumaric acid, malic acid, tartaric acid and/or citric acid; and/or their ammonium, sodium, potassium, calcium and/or magnesium salts, for (i) reducing the concentration of viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding material, or (ii) Inactivation of viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding.
  • ASFV African swine fever virus
  • AF14 Use of a combination of any of the AF 1 -7 and/or any of the AF 8-13 and/or the AF 12 for (i) reducing the levels of viruses and/or African swine fever virus (ASFV) in animal feed, and organic bedding material, or (ii) inactivation of viruses and/or African swine fever virus (ASFV) in animal feed and organic bedding material.
  • ASFV African swine fever virus
  • AF15 Use of a combination of AF14 to (i) reduce levels of virus and/or African swine fever virus (ASFV) in animal feed and organic bedding, or (ii) inactivate virus and/or African swine fever virus ( ASFV) in animal feed and organic bedding material.
  • ASFV African swine fever virus
  • ASFV African swine fever virus
  • AF16 Use of a combination of any of AF 1-7 and/or any of AF 8-10 and/or AF12-13 and/or any of AF 14-15 to (i) reduce the concentration of viruses and/or des African swine fever virus (ASFV) in animal feed and organic bedding, or (ii) inactivating virus and/or African swine fever virus (ASFV) in animal feed and organic bedding.
  • ASFV African swine fever virus
  • AF17 The use according to AF 1-16, characterized in that the animal feed
  • Pig feed is preferably hog feed for wild boar, boar, warthog, bush hog and/or river hog.
  • AF18 The use according to AF 1-16, characterized in that the animal feed
  • green fodder molasses fodder, roughage, straw, coarse fodder, juice fodder or concentrated fodder and organic bedding material consists of straw, straw pellets, etc.
  • AF19 The use according to one or more of the preceding AF, characterized in that the animal feed is administered in liquid and/or solid form.
  • AF20 The use according to one or more of the preceding AF, characterized in that the application of the combination or composition

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Abstract

L'invention concerne une composition pour réduire la concentration de virus et du virus de la peste porcine africaine (african swin fever, ASFV) dans des aliments pour animaux et dans des matériaux de litière organiques.
PCT/EP2022/077791 2021-10-07 2022-10-06 Composition pour réduire la concentration de virus et du virus de la peste porcine africaine (african swine fever, asfv) dans des aliments pour animaux et matériaux de litière pour étables WO2023057556A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP21201435.1 2021-10-07
EP21201435 2021-10-07
EP22186737.7A EP4176730A1 (fr) 2021-10-07 2022-07-25 Composition de réduction de la concentration de virus et du virus de la peste porcine africaine (african swine fever virus, asfv) dans les aliments pour animaux et les litières pour étables
EP22186737.7 2022-07-25

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WO2023057556A1 true WO2023057556A1 (fr) 2023-04-13

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