WO2023044611A1 - Laboratory mouse excrement collecting device - Google Patents

Laboratory mouse excrement collecting device Download PDF

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Publication number
WO2023044611A1
WO2023044611A1 PCT/CN2021/119661 CN2021119661W WO2023044611A1 WO 2023044611 A1 WO2023044611 A1 WO 2023044611A1 CN 2021119661 W CN2021119661 W CN 2021119661W WO 2023044611 A1 WO2023044611 A1 WO 2023044611A1
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Prior art keywords
barrier
box body
urine
collecting
feeding device
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PCT/CN2021/119661
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French (fr)
Chinese (zh)
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景晓源
刘欣安
王立平
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中国科学院深圳先进技术研究院
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Priority to PCT/CN2021/119661 priority Critical patent/WO2023044611A1/en
Publication of WO2023044611A1 publication Critical patent/WO2023044611A1/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
    • A01K1/03—Housing for domestic or laboratory animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
    • A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements

Definitions

  • the invention relates to a device for collecting excrement of experimental mice.
  • Urine detection in mice is a key physical and chemical indicator. Therefore, collecting the urine of mice is a very critical step.
  • the method of directly collecting animal metabolites with a feces-urine separation device is the metabolic cage method.
  • Chinese utility model patent ZL201310335359.X discloses a simple metabolic cage for mice.
  • This metabolic cage includes a feeding area and a metabolic area. The lower part of the metabolic area is mesh-shaped, and a funnel is connected to it, and a header is received under the funnel.
  • the metabolic cage has a simple structure and low cost, and can separate feces and urine to a certain extent.
  • this kind of metabolic cage requires the operator to put the mice from the feeding area into the metabolic area, and the operator needs to pay attention at all times; the separation of feces and urine is not complete, and the urine in the collection tube is easily mixed with feces; the whole device does not take sealing measures, and the urine in the collection tube The liquid is volatile, resulting in changes in the concentration of urine components.
  • the present invention proposes an experimental mouse excrement collection device, which can effectively separate the feces and urine of the mice.
  • the top of the box body is provided with a cover plate, and the box body is provided with three layers of barriers from top to bottom;
  • the first barrier is placed horizontally, and the space enclosed by it and the box body and cover plate is the mouse placement area;
  • the second barrier and the third barrier are sieve plates, and the second barrier and the third barrier are used to block When the mouse feces fall, the second barrier and the third barrier are set obliquely, and the second barrier and the third barrier can be pulled out from one side of the box;
  • a urine collection funnel is set under the third barrier, and the bottom of the funnel is fixed Urine collection tube, the urine collection tube is connected to the collection bottle;
  • a water feeding device and a feeding device on the outside of the box, and a food trough is fixed in the mouse placement area, and the outlet of the feeding device extends into the trough; the outlet of the water feeding device extends into the mouse from the side wall of the box. placed in the area.
  • a slideway is provided in the above-mentioned box, and the second barrier and the third barrier are respectively put in or drawn out through the slideway.
  • handles are provided on the second barrier and the third barrier to facilitate their extraction from the box.
  • the above-mentioned second barrier and the third barrier are provided with baffles on the side opposite to the handle.
  • one side of the cover plate is hinged to the box body, and a buckle is provided on the side opposite to the hinge, and the cover plate can be fixed to the box body through the buckle.
  • the above-mentioned water feeding device includes a graduated water bottle and a water outlet pipe connected thereto.
  • the end of the water outlet pipe is a water outlet, and the water outlet includes a ball.
  • the diameter of the ball is smaller than the diameter of the water outlet pipe.
  • the side wall at the end of the water outlet pipe is curved. Surface, when the arc surface is in contact with the ball, the surface is completely attached.
  • the above-mentioned feeding device is a funnel, and the feeding outlet at the lower part of the funnel extends into the feeding trough.
  • the side wall of the collection bottle is provided with a scale line
  • the mouth of the collection bottle is provided with a rubber stopper
  • the middle part of the rubber stopper is provided with an inlet.
  • the surface of the above-mentioned urine collection funnel is coated with a lyophobic material.
  • the bottom of the above-mentioned box is provided with a plurality of rollers for easy movement.
  • the mouse placement area of the present invention is equipped with a water feeding device and a feeding device, and is also integrated with a urine and feces separation and collection device. When urine and feces are to be collected, the mice do not need to be transferred;
  • the second barrier and the third barrier of the present invention can be extracted from the box to facilitate the collection of feces on the barrier;
  • the second barrier and the third barrier of the present invention are arranged obliquely, and the feces falling on the barrier will roll down to the lower side of the barrier.
  • the feces on the barrier will not Absorb urine, which is more conducive to complete collection of urine;
  • the surface of the urine collection funnel is coated with a lyophobic material, which is conducive to the complete collection of urine.
  • Fig. 1 is the structural diagram of experimental mouse excreta collecting device of the present invention
  • Fig. 2 is the structural diagram of collection bottle in Fig. 1;
  • Fig. 3 is a structural diagram of the water feeding device in Fig. 1;
  • Fig. 4 is a structural diagram of the second partition in Fig. 1 .
  • the present invention proposes a device for collecting excrement of experimental mice, comprising a box body 1, a cover plate 2 is provided on the top of the box body 1, and three layers of barriers are arranged from top to bottom in the box body 1; the first layer of barriers 3 is placed horizontally , the space surrounded by the box body 1 and the cover plate 2 is a mouse placement area; the second barrier 4 and the third barrier 5 are sieve plates, and the second barrier 4 and the third barrier 5 are used to block small Rat feces fall, the second barrier 4 and the third barrier 5 are arranged obliquely, and the second barrier 4 and the third barrier 5 can be drawn out from the side of the box body 1; the urine collection is arranged under the third barrier 5 Funnel 6, urine collecting tube 7 is fixed below the urine collecting funnel 6, and the urine collecting tube 7 is connected with a collecting bottle 19.
  • Casing body 1 outside is provided with water feeding device 8 and feeding device 9, is fixedly provided with food trough 11 in the mouse placement area, and the food outlet 10 of feeding device 9 stretches in the food trough 11;
  • the side wall of the casing 1 extends into the mouse placement area.
  • the mouse placement area of the present invention is provided with a water feeding device 8 and a feeding device 9, and also integrates a urine and feces separation and collection device. When the urine and feces are to be collected, the mice do not need to be transferred.
  • the water feeding device 8 and the feeding device 9 can be arranged on any side of the casing 1 .
  • the second barrier 4 and the third barrier 5 of the present invention are arranged obliquely, and the feces falling on the barrier will roll down to the lower side of the barrier.
  • the feces on the barrier will not Absorb and influence urine to fall into the urine collection funnel 6, which is more conducive to complete collection of urine.
  • a slideway is provided inside the box body 1, and the second barrier 4 and the third barrier 5 are put in or drawn out through the slideway respectively.
  • the size of the sieve holes on the second barrier 4 and the third barrier 5 can be the same or different, and can prevent the dropping of feces; Diameter of the mesh of barrier 4.
  • the second barrier 4 When extracting the feces of the mice, the second barrier 4 is pulled out, and the mouse feces are picked up with tweezers, and the third barrier 5 does not move. At this time, even if the mice discharge the feces, they will only fall on the third barrier. 5, there is no need to worry about the excrement falling into the urine collection funnel 6. After collecting the feces on the second barrier 4, send the second barrier 4 into the original position along the slideway. If the feces fall on the third barrier 5, the third barrier 5 can be pulled out and picked up with tweezers mouse feces.
  • the box body 1 of the present invention can be made of transparent material, and can also be made of mesh material.
  • the water feeding device 8 and the feeding device 9 can be fixed on the side wall of the casing 1 through the mounting frame.
  • the second barrier 4 and the third barrier 5 are provided with handles 12, which are convenient for the operator to grab and pull out from the box body 1 by hand.
  • the second barrier 4 and the third barrier 5 are provided with baffles 13 on the side opposite to the handle 12 .
  • the baffle plate 13 blocks and collects the falling feces on the second barrier 4 and the third barrier 5 .
  • one side of the cover plate 2 is hinged to the box body 1 , and a buckle 14 is provided on the side opposite to the hinge, and the cover plate 2 can be fixed to the box body 1 through the buckle 14 .
  • the operator When transferring the mice, the operator just unfastens the buckle 14 and flips the cover plate 2 over.
  • the water feeding device 8 includes a graduated water bottle 15 and a water outlet pipe 16 connected thereto.
  • the mouth 17 includes a ball 18, the diameter of which is smaller than that of the water outlet pipe 16, and the side wall at the end of the water outlet pipe 16 is an arc surface, and the surface of the arc surface is completely attached to the ball 18 when it contacts.
  • mice When the mice drink water, they lick the ball 18 to overcome the gravity and water resistance of the ball 18. The ball 18 moves upwards, and the water flows out. When not drinking, the ball 18 rolls down under its own weight. The side wall is fitted to block the water flow.
  • the feeding device 9 is a funnel structure, and the feeding outlet 10 at the lower part of the feeding device 9 protrudes into the feeding trough 11 .
  • the operator quantitatively puts the food into the upper opening of the feeding device 9, and the food slides down. When the food accumulates in the food trough 11, the food no longer slides down. Flow out from the food outlet 10, when avoiding too much food, the mouse will spill the food on the first layer of barrier 3.
  • the side wall of the collection bottle 19 is provided with a scale line, which is convenient for recording the urine amount of the mouse;
  • the mouth of the collection bottle 19 is provided with a rubber stopper 20, and the middle part of the rubber stopper 20 is provided
  • There is an entrance and the urine collection pipe 7 stretches into the middle part of the rubber plug 20 and is provided with the entrance to play a sealing role, and the rubber plug 20 prevents the volatilization of urine.
  • the surface of the urine collection funnel 6 is coated with a lyophobic material to prevent urine from stagnating on the surface of the urine collection funnel 6, reduce urine loss, and collect precisely.
  • the limit portion of urine collection funnel 6 is fixed on the inwall of casing 1, and collection bottle 19 can be fixed with fixture.
  • a plurality of rollers 21 are provided at the bottom of the box body 1 to facilitate the operator to move the collecting device.

Abstract

A laboratory mouse excrement collecting device, comprising a box body (1). A cover plate (2) is arranged at the top of the box body (1), and three layers of partitions are arranged in the box body (1) from top to bottom; a first-layer partition (3) is placed horizontally, and a space defined by the first-layer partition (3) together with the box body (1) and the cover plate (2) is a mouse placement area; a second partition (4) and a third partition (5) are sieve plates, the second partition (4) and the third partition (5) are used for blocking mouse excrement from falling down, the second partition (4) and the third partition (5) are arranged obliquely, and the second partition (4) and the third partition (5) can be drawn out from one side of the box body (1); a urine collecting funnel (6) is arranged below the third partition (5), a urine collecting pipe (7) is fixed below the urine collecting funnel (6), and the urine collecting pipe (7) is connected to a collecting container (19).

Description

一种实验小鼠排泄物收集装置A device for collecting excrement of experimental mice 技术领域technical field
本发明涉及一种实验小鼠排泄物收集装置。The invention relates to a device for collecting excrement of experimental mice.
背景技术Background technique
小鼠的尿液检测是一项比较关键的理化指标。因此收集小鼠的尿液是一个十分关键的步骤。用粪尿分离装置直接收集动物代谢产物的方法为代谢笼法。Urine detection in mice is a key physical and chemical indicator. Therefore, collecting the urine of mice is a very critical step. The method of directly collecting animal metabolites with a feces-urine separation device is the metabolic cage method.
中国实用新型专利ZL201310335359.X公开了一种简易小鼠代谢笼，这种代谢笼包括饲养区、代谢区，代谢区下方为网状，下接漏斗，漏斗下接收集管。这种代谢笼结构简单，成本低廉，能在一定程度上进行粪尿分离。然而这种代谢笼需要操作人员将小鼠从饲养区放到代谢区，需要操作人员时刻关注；粪尿分离不彻底，收集管内尿液容易混有粪便；整个装置没有采取封闭措施，收集管内尿液易挥发，导致尿液成分浓度变化。Chinese utility model patent ZL201310335359.X discloses a simple metabolic cage for mice. This metabolic cage includes a feeding area and a metabolic area. The lower part of the metabolic area is mesh-shaped, and a funnel is connected to it, and a header is received under the funnel. The metabolic cage has a simple structure and low cost, and can separate feces and urine to a certain extent. However, this kind of metabolic cage requires the operator to put the mice from the feeding area into the metabolic area, and the operator needs to pay attention at all times; the separation of feces and urine is not complete, and the urine in the collection tube is easily mixed with feces; the whole device does not take sealing measures, and the urine in the collection tube The liquid is volatile, resulting in changes in the concentration of urine components.
发明内容Contents of the invention
为了弥补现有技术的不足，本发明提出一种实验小鼠排泄物收集装置，可以将小鼠的粪便和尿液有效分离。In order to make up for the deficiencies of the prior art, the present invention proposes an experimental mouse excrement collection device, which can effectively separate the feces and urine of the mice.
本发明解决上述问题的技术方案是：The technical scheme that the present invention solves the above problems is:
一种实验小鼠排泄物收集装置，其特殊之处在于：An experimental mouse excrement collection device, which is special in that:
包括箱体，箱体顶部设有盖板，箱体内从上至下设有三层隔挡；Including the box body, the top of the box body is provided with a cover plate, and the box body is provided with three layers of barriers from top to bottom;
第一层隔挡水平放置，其与箱体和盖板围成的空间为小鼠放置区；第二隔挡和第三隔挡为筛板，第二隔挡和第三隔挡用于阻挡小鼠粪便落下，第二隔挡和第三隔挡斜向设置，且第二隔挡和第三隔挡可从箱体一侧抽出；第三隔挡下方设置尿液收集漏斗，漏斗下方固定尿液收集管，尿液收集管与收集瓶连接；The first barrier is placed horizontally, and the space enclosed by it and the box body and cover plate is the mouse placement area; the second barrier and the third barrier are sieve plates, and the second barrier and the third barrier are used to block When the mouse feces fall, the second barrier and the third barrier are set obliquely, and the second barrier and the third barrier can be pulled out from one side of the box; a urine collection funnel is set under the third barrier, and the bottom of the funnel is fixed Urine collection tube, the urine collection tube is connected to the collection bottle;
箱体外侧设有喂水装置和喂食装置，小鼠放置区内固设有食槽，喂食装置的出食口伸入食槽内；喂水装置的出水口从箱体侧壁伸入小鼠放置区内。There is a water feeding device and a feeding device on the outside of the box, and a food trough is fixed in the mouse placement area, and the outlet of the feeding device extends into the trough; the outlet of the water feeding device extends into the mouse from the side wall of the box. placed in the area.
进一步地，上述箱体内设有滑道，第二隔挡和第三隔挡分别通过滑道放进 或抽出。Further, a slideway is provided in the above-mentioned box, and the second barrier and the third barrier are respectively put in or drawn out through the slideway.
进一步地，上述第二隔挡和第三隔挡上均设有把手，方便其从箱体抽出。Further, handles are provided on the second barrier and the third barrier to facilitate their extraction from the box.
进一步地，上述第二隔挡和第三隔挡相对于把手一侧均设有挡板。Further, the above-mentioned second barrier and the third barrier are provided with baffles on the side opposite to the handle.
进一步地，上述盖板的一侧与箱体铰接，其与铰接相对一侧设有卡扣，盖板可通过卡扣与箱体固定。Further, one side of the cover plate is hinged to the box body, and a buckle is provided on the side opposite to the hinge, and the cover plate can be fixed to the box body through the buckle.
进一步地，上述喂水装置包括带刻度的水瓶和与其连接的出水管，出水管的端部为出水嘴，出水嘴包括一滚珠，滚珠的直径小于出水管直径，出水管端部侧壁呈弧面，该弧面与滚珠接触时表面完全贴合。Further, the above-mentioned water feeding device includes a graduated water bottle and a water outlet pipe connected thereto. The end of the water outlet pipe is a water outlet, and the water outlet includes a ball. The diameter of the ball is smaller than the diameter of the water outlet pipe. The side wall at the end of the water outlet pipe is curved. Surface, when the arc surface is in contact with the ball, the surface is completely attached.
进一步地，上述喂食装置为一漏斗，漏斗下部的出食口伸入食槽内。Further, the above-mentioned feeding device is a funnel, and the feeding outlet at the lower part of the funnel extends into the feeding trough.
进一步地，上述收集瓶的侧壁上设有刻度线，收集瓶的瓶口处设有橡胶塞，橡胶塞中部设有入口。Further, the side wall of the collection bottle is provided with a scale line, the mouth of the collection bottle is provided with a rubber stopper, and the middle part of the rubber stopper is provided with an inlet.
进一步地，上述尿液收集漏斗的表面涂覆疏液材料。Further, the surface of the above-mentioned urine collection funnel is coated with a lyophobic material.
进一步地，上述箱体的底部设有多个滚轮，方便移动。Further, the bottom of the above-mentioned box is provided with a plurality of rollers for easy movement.
本发明的优点：Advantages of the present invention:
1)本发明的小鼠放置区设有喂水装置和喂食装置，还集成尿液粪便分离、收集装置，在要进行收集尿液和粪便时，无需将小鼠转移；1) The mouse placement area of the present invention is equipped with a water feeding device and a feeding device, and is also integrated with a urine and feces separation and collection device. When urine and feces are to be collected, the mice do not need to be transferred;
2)本发明的第二隔挡和第三隔挡可从箱体中抽取，便于收集隔挡上的粪便；2) The second barrier and the third barrier of the present invention can be extracted from the box to facilitate the collection of feces on the barrier;
3)本发明的第二隔挡和第三隔挡斜向设置，粪便掉在隔挡上会向隔挡较低一侧滚落，当小鼠的尿液落下时，隔挡上粪便不会吸收尿液，更有利于尿液完全收集；3) The second barrier and the third barrier of the present invention are arranged obliquely, and the feces falling on the barrier will roll down to the lower side of the barrier. When the urine of the mice falls, the feces on the barrier will not Absorb urine, which is more conducive to complete collection of urine;
4)尿液收集漏斗的表面涂覆疏液材料，有利于尿液完全收集。4) The surface of the urine collection funnel is coated with a lyophobic material, which is conducive to the complete collection of urine.
附图说明Description of drawings
图1为本发明实验小鼠排泄物收集装置的结构图；Fig. 1 is the structural diagram of experimental mouse excreta collecting device of the present invention;
图2为图1中收集瓶的结构图；Fig. 2 is the structural diagram of collection bottle in Fig. 1;
图3为图1中喂水装置的结构图；Fig. 3 is a structural diagram of the water feeding device in Fig. 1;
图4为图1中第二隔挡的结构图。Fig. 4 is a structural diagram of the second partition in Fig. 1 .
图中：1、箱体，2、盖板，3、第一层隔挡，4、第二隔挡，5、第三隔挡，6、尿液收集漏斗，7、尿液收集管，8、喂水装置，9、喂食装置，10、出食口，11、食槽，12、把手；13、挡板；14、卡扣；15、水瓶；16、出水管；17、出水嘴；18、滚珠；19、收集瓶；20、橡胶塞；21、滚轮。In the figure: 1. box body, 2. cover plate, 3. first barrier, 4. second barrier, 5. third barrier, 6. urine collection funnel, 7. urine collection tube, 8 , water feeding device, 9, feeding device, 10, food outlet, 11, trough, 12, handle; 13, baffle; 14, buckle; 15, water bottle; 16, water outlet pipe; 17, water outlet; 18 , ball; 19, collection bottle; 20, rubber stopper; 21, roller.
具体实施方式Detailed ways
为使本发明实施方式的目的、技术方案和优点更加清楚，下面将结合本发明实施方式中的附图，对本发明实施方式中的技术方案进行清楚、完整地描述，显然，所描述的实施方式是本发明一部分实施方式，而不是全部的实施方式。基于本发明中的实施方式，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施方式，都属于本发明保护的范围。因此，以下对在附图中提供的本发明的实施方式的详细描述并非旨在限制要求保护的本发明的范围，而是仅仅表示本发明的选定实施方式。In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments It is some embodiments of the present invention, but not all of them. Based on the implementation manners in the present invention, all other implementation manners obtained by persons of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention. Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the invention.
本发明提出一种实验小鼠排泄物收集装置，包括箱体1，箱体1顶部设有盖板2，箱体1内从上至下设有三层隔挡；第一层隔挡3水平放置，其与箱体1和盖板2围成的空间为小鼠放置区；第二隔挡4和第三隔挡5为筛板，第二隔挡4和第三隔挡5用于阻挡小鼠粪便落下，第二隔挡4和第三隔挡5斜向设置，且第二隔挡4和第三隔挡5可从箱体1一侧抽出；第三隔挡5下方设置尿液收集漏斗6，尿液收集漏斗6下方固定尿液收集管7，尿液收集管7与收集瓶19连接。The present invention proposes a device for collecting excrement of experimental mice, comprising a box body 1, a cover plate 2 is provided on the top of the box body 1, and three layers of barriers are arranged from top to bottom in the box body 1; the first layer of barriers 3 is placed horizontally , the space surrounded by the box body 1 and the cover plate 2 is a mouse placement area; the second barrier 4 and the third barrier 5 are sieve plates, and the second barrier 4 and the third barrier 5 are used to block small Rat feces fall, the second barrier 4 and the third barrier 5 are arranged obliquely, and the second barrier 4 and the third barrier 5 can be drawn out from the side of the box body 1; the urine collection is arranged under the third barrier 5 Funnel 6, urine collecting tube 7 is fixed below the urine collecting funnel 6, and the urine collecting tube 7 is connected with a collecting bottle 19.
箱体1外侧设有喂水装置8和喂食装置9，小鼠放置区内固设有食槽11，喂食装置9的出食口10伸入食槽11内；喂水装置8的出水口从箱体1侧壁伸入小鼠放置区内。 Casing body 1 outside is provided with water feeding device 8 and feeding device 9, is fixedly provided with food trough 11 in the mouse placement area, and the food outlet 10 of feeding device 9 stretches in the food trough 11; The side wall of the casing 1 extends into the mouse placement area.
本发明的小鼠放置区设有喂水装置8和喂食装置9，还集成尿液粪便分离、收集装置，在要进行收集尿液和粪便时，无需将小鼠转移。喂水装置8和喂食装置9可以设置在箱体1的任何一侧。The mouse placement area of the present invention is provided with a water feeding device 8 and a feeding device 9, and also integrates a urine and feces separation and collection device. When the urine and feces are to be collected, the mice do not need to be transferred. The water feeding device 8 and the feeding device 9 can be arranged on any side of the casing 1 .
本发明的第二隔挡4和第三隔挡5斜向设置，粪便掉在隔挡上会向隔挡较 低一侧滚落，当小鼠的尿液落下时，隔挡上粪便不会吸收和影响尿液落入尿液收集漏斗6中，更有利于尿液完全收集。The second barrier 4 and the third barrier 5 of the present invention are arranged obliquely, and the feces falling on the barrier will roll down to the lower side of the barrier. When the urine of the mice falls, the feces on the barrier will not Absorb and influence urine to fall into the urine collection funnel 6, which is more conducive to complete collection of urine.
作为本发明的一个优选实施例，所述箱体1内设有滑道，第二隔挡4和第三隔挡5分别通过滑道放进或抽出。As a preferred embodiment of the present invention, a slideway is provided inside the box body 1, and the second barrier 4 and the third barrier 5 are put in or drawn out through the slideway respectively.
第二隔挡4和第三隔挡5上的筛孔大小可以相同，也可以不同，都可以阻止粪便掉落；当二者孔径不同时，第三隔挡5上的筛孔直径小于第二隔挡4的筛孔直径。The size of the sieve holes on the second barrier 4 and the third barrier 5 can be the same or different, and can prevent the dropping of feces; Diameter of the mesh of barrier 4.
当提取小鼠粪便时，将第二隔挡4抽出，用镊子夹取小鼠粪便，第三隔挡5不动，此时即使小鼠排下粪便，也只会掉落在第三隔挡5上，也不用担心粪便落入尿液收集漏斗6中。收集完第二隔挡4上的粪便，将第二隔挡4沿滑道送入原位，如粪便掉落在第三隔挡5上，可将第三隔挡5抽出，用镊子夹取小鼠粪便。When extracting the feces of the mice, the second barrier 4 is pulled out, and the mouse feces are picked up with tweezers, and the third barrier 5 does not move. At this time, even if the mice discharge the feces, they will only fall on the third barrier. 5, there is no need to worry about the excrement falling into the urine collection funnel 6. After collecting the feces on the second barrier 4, send the second barrier 4 into the original position along the slideway. If the feces fall on the third barrier 5, the third barrier 5 can be pulled out and picked up with tweezers mouse feces.
本发明的箱体1可以采用透明的材质制成，也可以采用网状材质制成。喂水装置8和喂食装置9可以通过安装架固定在箱体1的侧壁上。The box body 1 of the present invention can be made of transparent material, and can also be made of mesh material. The water feeding device 8 and the feeding device 9 can be fixed on the side wall of the casing 1 through the mounting frame.
作为本发明的一个优选实施例，所述第二隔挡4和第三隔挡5上均设有把手12，方便操作人员用手抓取其从箱体1抽出。As a preferred embodiment of the present invention, the second barrier 4 and the third barrier 5 are provided with handles 12, which are convenient for the operator to grab and pull out from the box body 1 by hand.
作为本发明的一个优选实施例，所述第二隔挡4和第三隔挡5相对于把手12一侧均设有挡板13。挡板13阻挡并收集第二隔挡4和第三隔挡5上的粪便落下。As a preferred embodiment of the present invention, the second barrier 4 and the third barrier 5 are provided with baffles 13 on the side opposite to the handle 12 . The baffle plate 13 blocks and collects the falling feces on the second barrier 4 and the third barrier 5 .
作为本发明的一个优选实施例，所述盖板2的一侧与箱体1铰接，其与铰接相对一侧设有卡扣14，盖板2可通过卡扣14与箱体1固定。操作人员在转移小鼠时，解开卡扣14，翻转盖板2即可。As a preferred embodiment of the present invention, one side of the cover plate 2 is hinged to the box body 1 , and a buckle 14 is provided on the side opposite to the hinge, and the cover plate 2 can be fixed to the box body 1 through the buckle 14 . When transferring the mice, the operator just unfastens the buckle 14 and flips the cover plate 2 over.
作为本发明的一个优选实施例，所述喂水装置8包括带刻度的水瓶15和与其连接的出水管16，出水管16为一斜弯管，出水管16的端部为出水嘴17，出水嘴17包括一滚珠18，滚珠18的直径小于出水管16直径，出水管16端部侧壁呈弧面，该弧面与滚珠18接触时表面完全贴合。As a preferred embodiment of the present invention, the water feeding device 8 includes a graduated water bottle 15 and a water outlet pipe 16 connected thereto. The mouth 17 includes a ball 18, the diameter of which is smaller than that of the water outlet pipe 16, and the side wall at the end of the water outlet pipe 16 is an arc surface, and the surface of the arc surface is completely attached to the ball 18 when it contacts.
小鼠喝水时，舔舐滚珠18，克服滚珠18的重力和水阻力，滚珠18向上移动，水流出，不喝水时，滚珠18受自重向下滚落，滚珠18与出水管16端部侧壁贴合，将水流阻断。When the mice drink water, they lick the ball 18 to overcome the gravity and water resistance of the ball 18. The ball 18 moves upwards, and the water flows out. When not drinking, the ball 18 rolls down under its own weight. The side wall is fitted to block the water flow.
作为本发明的一个优选实施例，所述喂食装置9为一漏斗结构，喂食装置9下部的出食口10伸入食槽11内。As a preferred embodiment of the present invention, the feeding device 9 is a funnel structure, and the feeding outlet 10 at the lower part of the feeding device 9 protrudes into the feeding trough 11 .
操作人员定量将食物放入喂食装置9的上部开口，食物向下滑落，当食物在食槽11内堆积时，食物不再滑落，小鼠将食槽11内的食物吃掉后，食物才会从出食口10流出，避免食物过多时，小鼠将食物洒落在第一层隔挡3上。The operator quantitatively puts the food into the upper opening of the feeding device 9, and the food slides down. When the food accumulates in the food trough 11, the food no longer slides down. Flow out from the food outlet 10, when avoiding too much food, the mouse will spill the food on the first layer of barrier 3.
作为本发明的一个优选实施例，所述收集瓶19的侧壁上设有刻度线，方便记录小鼠的尿液量；收集瓶19的瓶口处设有橡胶塞20，橡胶塞20中部设有入口，尿液收集管7伸入橡胶塞20中部设有入口内，起到密封作用，橡胶塞20防止尿液挥发。As a preferred embodiment of the present invention, the side wall of the collection bottle 19 is provided with a scale line, which is convenient for recording the urine amount of the mouse; the mouth of the collection bottle 19 is provided with a rubber stopper 20, and the middle part of the rubber stopper 20 is provided There is an entrance, and the urine collection pipe 7 stretches into the middle part of the rubber plug 20 and is provided with the entrance to play a sealing role, and the rubber plug 20 prevents the volatilization of urine.
作为本发明的一个优选实施例，所述尿液收集漏斗6的表面涂覆疏液材料，防止尿液滞留在尿液收集漏斗6的表面，减少尿液损失，精准收集。尿液收集漏斗6的边部固定在箱体1的内壁上，收集瓶19可以用固定装置固定。As a preferred embodiment of the present invention, the surface of the urine collection funnel 6 is coated with a lyophobic material to prevent urine from stagnating on the surface of the urine collection funnel 6, reduce urine loss, and collect precisely. The limit portion of urine collection funnel 6 is fixed on the inwall of casing 1, and collection bottle 19 can be fixed with fixture.
作为本发明的一个优选实施例，所述箱体1的底部设有多个滚轮21，方便操作人将收集装置进行移动。As a preferred embodiment of the present invention, a plurality of rollers 21 are provided at the bottom of the box body 1 to facilitate the operator to move the collecting device.
以上所述仅为本发明的实施例，并非以此限制本发明的保护范围，凡是利用本发明说明书及附图内容所作的等效结构或等效流程变换，或直接或间接运用在其他相关的系统领域，均同理包括在本发明的保护范围内。The above description is only an embodiment of the present invention, and is not intended to limit the protection scope of the present invention. Any equivalent structure or equivalent process conversion made by using the description of the present invention and the contents of the accompanying drawings, or directly or indirectly used in other related The system field is equally included in the scope of protection of the present invention.

Claims (10)

  1. 一种实验小鼠排泄物收集装置，其特征在于：A device for collecting excrement of experimental mice, characterized in that:
    包括箱体(1)，箱体(1)顶部设有盖板(2)，箱体(1)内从上至下设有三层隔挡；It includes a box body (1), the top of the box body (1) is provided with a cover plate (2), and the box body (1) is provided with three layers of barriers from top to bottom;
    第一层隔挡(3)水平放置，其与箱体(1)和盖板(2)围成的空间为小鼠放置区；第二隔挡(4)和第三隔挡(5)为筛板，第二隔挡(4)和第三隔挡(5)用于阻挡小鼠粪便落下，第二隔挡(4)和第三隔挡(5)斜向设置，且第二隔挡(4)和第三隔挡(5)可从箱体(1)一侧抽出；第三隔挡(5)下方设置尿液收集漏斗(6)，尿液收集漏斗(6)下方固定尿液收集管(7)，尿液收集管(7)与收集瓶(19)连接；The first layer of barrier (3) is placed horizontally, and the space surrounded by it and the casing (1) and cover plate (2) is a mouse placement area; the second barrier (4) and the third barrier (5) are The sieve plate, the second barrier (4) and the third barrier (5) are used to stop the dropping of mouse feces, the second barrier (4) and the third barrier (5) are arranged obliquely, and the second barrier (4) and the third barrier (5) can be drawn out from one side of the box body (1); a urine collection funnel (6) is arranged below the third barrier (5), and the urine collection funnel (6) is fixed below the urine collection funnel (6). Collecting tube (7), urine collecting tube (7) is connected with collecting bottle (19);
    箱体(1)外侧设有喂水装置(8)和喂食装置(9)，小鼠放置区内固设有食槽(11)，喂食装置(9)的出食口(10)伸入食槽(11)内；喂水装置(8)的出水口从箱体(1)侧壁伸入小鼠放置区内。A water feeding device (8) and a feeding device (9) are provided on the outside of the casing (1), and a food trough (11) is fixed in the mouse placement area, and the food outlet (10) of the feeding device (9) stretches into the food. In the groove (11); the water outlet of the water feeding device (8) stretches into the mouse placement area from the side wall of the casing (1).
  2. 根据权利要求1所述的一种实验小鼠排泄物收集装置，其特征在于：A device for collecting excrement of experimental mice according to claim 1, characterized in that:
    所述箱体(1)内设有滑道，第二隔挡(4)和第三隔挡(5)分别通过滑道放进或抽出。The box body (1) is provided with a slideway, and the second barrier (4) and the third barrier (5) are respectively put in or drawn out through the slideway.
  3. 根据权利要求2所述的一种实验小鼠排泄物收集装置，其特征在于：A device for collecting excrement of experimental mice according to claim 2, characterized in that:
    所述第二隔挡(4)和第三隔挡(5)上均设有把手(12)，方便其从箱体(1)抽出。Both the second barrier (4) and the third barrier (5) are provided with handles (12) to facilitate their extraction from the box body (1).
  4. 根据权利要求3所述的一种实验小鼠排泄物收集装置，其特 征在于：A kind of experimental mouse excrement collection device according to claim 3, is characterized in that:
    所述第二隔挡(4)和第三隔挡(5)相对于把手(12)一侧均设有挡板(13)。Both the second barrier (4) and the third barrier (5) are provided with baffles (13) on the side opposite to the handle (12).
  5. 根据权利要求1-4任一所述的一种实验小鼠排泄物收集装置，其特征在于：A device for collecting excrement of experimental mice according to any one of claims 1-4, characterized in that:
    所述盖板(2)的一侧与箱体(1)铰接，其与铰接相对一侧设有卡扣(14)，盖板(2)可通过卡扣(14)与箱体(1)固定。One side of the cover plate (2) is hinged with the box body (1), and a buckle (14) is provided on the side opposite to the hinge, and the cover plate (2) can be connected with the box body (1) through the buckle (14) fixed.
  6. 根据权利要求5所述的一种实验小鼠排泄物收集装置，其特征在于：A device for collecting excrement of experimental mice according to claim 5, characterized in that:
    所述喂水装置(8)包括带刻度的水瓶(15)和与其连接的出水管(16)，出水管(16)的端部为出水嘴(17)，出水嘴(17)包括一滚珠(18)，滚珠(18)的直径小于出水管(16)直径，出水管(16)端部侧壁呈弧面，该弧面与滚珠(18)接触时表面完全贴合。Described water feeding device (8) comprises the water bottle (15) with scale and the water outlet pipe (16) that is connected with it, and the end of water outlet pipe (16) is water outlet (17), and water outlet (17) comprises a ball ( 18), the diameter of the ball (18) is less than the diameter of the water outlet pipe (16), and the side wall at the end of the water outlet pipe (16) is an arc surface, and the surface of the arc surface is completely fitted when the ball (18) contacts.
  7. 根据权利要求6所述的一种实验小鼠排泄物收集装置，其特征在于：A device for collecting excrement of experimental mice according to claim 6, characterized in that:
    所述喂食装置(9)为一漏斗结构，喂食装置(9)下部的出食口(10)伸入食槽(11)内。The feeding device (9) is a funnel structure, and the feeding outlet (10) at the bottom of the feeding device (9) extends into the feeding trough (11).
  8. 根据权利要求7所述的一种实验小鼠排泄物收集装置，其特征在于：A device for collecting excrement of experimental mice according to claim 7, characterized in that:
    所述收集瓶(19)的侧壁上设有刻度线，收集瓶(19)的瓶口处设有橡胶塞(20)，橡胶塞(20)中部设有入口。The side wall of the collection bottle (19) is provided with a scale line, the bottleneck of the collection bottle (19) is provided with a rubber stopper (20), and the middle part of the rubber stopper (20) is provided with an entrance.
  9. 根据权利要求8所述的一种实验小鼠排泄物收集装置，其特 征在于：A kind of experimental mouse excrement collection device according to claim 8, is characterized in that:
    所述尿液收集漏斗(6)的表面涂覆疏液材料。The surface of the urine collection funnel (6) is coated with a lyophobic material.
  10. 根据权利要求9所述的一种实验小鼠排泄物收集装置，其特征在于：A device for collecting excrement of experimental mice according to claim 9, characterized in that:
    所述箱体(1)的底部设有多个滚轮(21)，方便移动。The bottom of the box (1) is provided with a plurality of rollers (21) for easy movement.
PCT/CN2021/119661 2021-09-22 2021-09-22 Laboratory mouse excrement collecting device WO2023044611A1 (en)

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CN209185349U (en) * 2018-10-24 2019-08-02 贵州医科大学 A kind of mouse metabolism cage
US20200060236A1 (en) * 2016-06-29 2020-02-27 Riken System for restraining mouse
CN112602601A (en) * 2020-12-23 2021-04-06 中国科学院亚热带农业生态研究所 Accurate feeding of goat and automatic monitoring's of metabolism breathe metabolism cage

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Publication number Priority date Publication date Assignee Title
CN202663932U (en) * 2012-06-26 2013-01-16 南方医科大学 Improved metabolism cage for laboratory mice
CN203775876U (en) * 2013-12-24 2014-08-20 苏州大学 Rat and mouse metabolism cage
US20200060236A1 (en) * 2016-06-29 2020-02-27 Riken System for restraining mouse
CN206323949U (en) * 2016-12-22 2017-07-14 上海中医药大学附属岳阳中西医结合医院 A kind of experiment mice metabolic cage for being used to collect sterile urine
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