WO2023032654A1 - Procédé de production d'un dérivé de 4-bromoisothiazolinone, et dérivé de 4-bromoisothiazolinone - Google Patents

Procédé de production d'un dérivé de 4-bromoisothiazolinone, et dérivé de 4-bromoisothiazolinone Download PDF

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WO2023032654A1
WO2023032654A1 PCT/JP2022/030945 JP2022030945W WO2023032654A1 WO 2023032654 A1 WO2023032654 A1 WO 2023032654A1 JP 2022030945 W JP2022030945 W JP 2022030945W WO 2023032654 A1 WO2023032654 A1 WO 2023032654A1
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bromoisothiazolinone
derivative
producing
solvent
formula
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PCT/JP2022/030945
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English (en)
Japanese (ja)
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修 小林
智子 立元
大洋 横井
新太郎 染谷
慎司 中村
歩 加藤
樹生 森田
千晴 荒木
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オルガノ株式会社
公益財団法人相模中央化学研究所
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Priority claimed from JP2022077413A external-priority patent/JP2023036512A/ja
Application filed by オルガノ株式会社, 公益財団法人相模中央化学研究所 filed Critical オルガノ株式会社
Priority to CN202280057223.4A priority Critical patent/CN117836280A/zh
Publication of WO2023032654A1 publication Critical patent/WO2023032654A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Definitions

  • the present invention relates to a method for producing a 4-bromoisothiazolinone derivative, and a 4-bromoisothiazolinone derivative obtained by the production method.
  • Antibacterial agents are used in various situations such as industrial preservatives, construction materials, paints, adhesives, leather, paper pulp, cooling towers, industrial oils, textiles, cleaning aids, cosmetics, and household products. It is used. As an antibacterial agent, the development of a safer antibacterial agent with a low possibility of causing health hazards such as allergic contact dermatitis is desired. 4-bromoisothiazolinone derivatives belong to isothiazoline antibacterial agents and are reported to have bactericidal and antibacterial activities (see, for example, Patent Document 1).
  • a 4-bromoisothiazolinone derivative can be produced by brominating an isothiazolinone compound unsubstituted at the 4-position, and is described, for example, in Patent Documents 1 to 3 and Non-Patent Documents 1 and 2.
  • Patent Documents 1 to 3 and Non-Patent Documents 1 and 2. none of these methods are necessarily satisfactory in terms of reaction yield, product purity, etc., and are difficult to put into practical use.
  • Patent Document 1 describes a bromination reaction of 2-methyl-4-isothiazolin-3-one in a dichloroethane solvent using bromine (1 equivalent) to give the desired 4-bromo-2-methyl-4-
  • the yield of isothiazolin-3-one is stated to be only 14%.
  • 2-(1,1,3,3-tetramethylbutyl)-4-isothiazolin-3-one is brominated using N-bromosuccinimide (2 equivalents) in a chloroform solvent, the desired product yield is stated as 54%.
  • Non-Patent Document 1 describes a bromination reaction of 2-cyclohexyl-4-isothiazolin-3-one using bromine (1 equivalent) and a bromine reaction of 2-(2-phenylethyl)-4-isothiazolin-3-one. (3 equivalents), the desired 2-alkyl-4-bromo-4-isothiazolin-3-one derivatives are obtained in yields of 75% and 63%, respectively.
  • the addition of an excess amount of bromine in the same reaction results in the by-production of a 2-alkyl-4,5-dibromo-4-isothiazolin-3-one derivative in which the 5-position of the isothiazoline ring is also brominated.
  • Patent Document 2 2-octyl-4-isothiazolin-3-one is subjected to a bromination reaction in an N,N-dimethylformamide solvent using 3 equivalents of bromine to give the desired 4-bromo-2- Octyl-4-isothiazolin-3-one is reported to be obtained in high yields of 93%, but 4,5-dibromo-4-isothiazolin-3-one formed when excess bromine is used. No mention is made of by-products of on-derivatives. When an excessive amount of bromine is used, a step of treating the highly reactive excessive bromine after completion of the reaction is required, and it cannot be said to be an efficient production method from the viewpoint of economy.
  • Non-Patent Document 2 N,N-di- ⁇ -methylbenzyl-3,3-dithiodipropionamide is reacted with sulfuryl chloride, followed by bromination in a dichloromethane solvent using bromine. , the desired 2-(S)- ⁇ -methylbenzyl-4-bromo-4-isothiazolin-3-one is obtained in a yield of 72%, but the isothiazoline ring is chlorinated at the 5-position.
  • 2-(S)- ⁇ -methylbenzyl-4-bromo-5-chloro-4-isothiazolin-3-one is produced as a by-product, and the method cannot necessarily be said to have good selectivity.
  • Patent Document 3 discloses that 4-bromo-2-[1-(3-chlorophenyl)-1-methylethyl]-4-isothiazolin-3-one, which is an intermediate for the production of herbicidally active compounds, has a corresponding 4-position free Bromination of substituted 2-[1-(3-chlorophenyl)-1-methylethyl]-4-isothiazolin-3-one with 1 equivalent of bromine in acetic acid in 88% yield
  • the raw material used is a bulky and highly fat-soluble substituent containing an aromatic group such as 1-(3-chlorophenyl)-1-methylethyl group on the nitrogen atom at the 2-position. have.
  • An object of the present invention is to provide a method for producing a highly pure 4-bromoisothiazolinone derivative with good selectivity and yield, and a 4-bromoisothiazolinone derivative obtained by the production method.
  • the present invention uses formula (1) (Wherein, R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms.)
  • a method for producing a 4-bromoisothiazolinone derivative represented by formula (2) (Wherein R is the same as formula (1)), an isothiazolinone compound or a chemically acceptable salt thereof is brominated in an aqueous solvent or a mixed solvent of an aqueous solvent and an organic solvent.
  • the purification method in step b) is preferably a method by recrystallization or slurry washing.
  • the solvent used for recrystallization or slurry washing is preferably at least one of ethyl acetate, chlorobenzene, and o-dichlorobenzene.
  • the amount of the water solvent used is preferably in the range of 0.1 to 10 in weight ratio to the starting material.
  • the brominating agent is preferably bromine, N-bromosuccinimide, or 1,3-dibromo-5,5-dimethylhydantoin.
  • the reaction temperature in the bromination is preferably in the range of 0°C to 80°C.
  • R is preferably an alkyl group having 1 to 4 carbon atoms.
  • isothiazolinone compound represented by formula (2) or a chemically acceptable salt thereof, which is a 4-bromoisothiazolinone derivative represented by formula (1) and which is contained in the 4-bromoisothiazolinone derivative is less than 100 ppm.
  • R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms.
  • R is the same as in formula (1).
  • the present inventors have found that, in a reaction for brominating a specific isothiazolinone compound unsubstituted at the 4-position using a brominating agent, in a water solvent or a mixed solvent of a water solvent and an organic solvent It was found that a 4-bromoisothiazolinone derivative selectively brominated at the 4-position can be produced in good yield by conducting the reaction in the above. Further, the present inventors have found a purification method by which a highly pure target product can be efficiently obtained by recrystallization or slurry washing of the obtained 4-bromoisothiazolinone derivative under specific conditions.
  • a method for producing a 4-bromoisothiazolinone derivative according to an embodiment of the present invention comprises formula (1) (Wherein, R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms). .), comprising: formula (2) (Wherein R is the same as in formula (1)), an isothiazolinone compound (hereinafter sometimes referred to as isothiazolinone compound (2)) or a chemically acceptable salt thereof is added to an aqueous solvent. bromination using a brominating agent in a mixed solvent of an aqueous solvent and an organic solvent.
  • the method for producing a 4-bromoisothiazolinone derivative comprises Step a): Formula (2) (Wherein, R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms.) An isothiazolinone compound or a chemically acceptable salt thereof represented by In a solvent, bromination using a brominating agent, formula (1) (Wherein R is the same as formula (2).) Synthesizing a 4-bromoisothiazolinone derivative represented by Step b): purifying the 4-bromoisothiazolinone derivative obtained in step a).
  • alkyl group having 1 to 12 carbon atoms represented by R examples include methyl group, ethyl group, n-propyl group, isopropyl group, cyclopropyl group, n-butyl group, isobutyl group, tert-butyl group, cyclobutyl group, n-pentyl group, isopentyl group, neopentyl group, 1-ethylpropyl group, n-hexyl group, isohexyl group, 1,1-dimethylbutyl group, 2,2-dimethylbutyl group, 3,3-dimethylbutyl group , 2-ethylbutyl group, cyclohexyl group, n-heptyl group, cycloheptyl group, n-octyl group, cyclooctyl group, n-nonyl group, cyclononyl group, n-decyl group, cycl
  • the isothiazolinone compound (2) may form a chemically acceptable salt.
  • the type of salt is not particularly limited, but examples include hydrochloride, hydrobromide, hydroiodide, nitrate, sulfate and the like. Hydrochloride is preferred because it is readily available.
  • the bromination reaction in the method for producing a 4-bromoisothiazolinone derivative according to this embodiment is carried out in the presence of a water solvent.
  • This bromination reaction may be carried out using only water as a solvent, or may be carried out in a mixed solvent of water and an organic solvent which hardly affects the reaction.
  • organic solvents used for bromination include halogen solvents such as chloroform, dichloromethane and carbon tetrachloride; amide solvents such as dimethylformamide and dimethylacetamide; or toluene, xylene, mesitylene, chlorobenzene, o-dichlorobenzene and the like.
  • Aromatic solvents and the like are included. From the viewpoint of good yield, it is preferable to use an aromatic solvent, and it is more preferable to use chlorobenzene or o-dichlorobenzene.
  • the amount of water may be, for example, in the range of 0.1 to 10 in weight ratio to the raw material.
  • the mixing ratio of water and the organic solvent is not particularly limited. A mixing ratio appropriately selected from the range of 1 may be used.
  • the brominating agent used in the bromination reaction includes bromine, bromine-1,4-dioxane complex, N-bromosuccinimide (hereinafter sometimes referred to as NBS), 1,3-dibromo-5,5- dimethylhydantoin (hereinafter sometimes referred to as DBH), tribromoisocyanuric acid, dibromoisocyanuric acid (hereinafter sometimes referred to as DBI), monosodium bromoisocyanurate, tetrabutylammonium tribromide, bromotrichloromethane, 1,2-dibromo-1,1,2,2-tetrachloroethane, carbon tetrabromide, trimethylphenylammonium tribromide, benzyltrimethylammonium tribromide, tetrapropylammonium nonabromide, pyridinium bromide perbromide, pyridinium bromochromate, 1 -butyl-3-methylimi
  • the amount of the brominating agent to be used is preferably 0.5 to 2 molar equivalents relative to the amount of isothiazolinone compound (2) or a chemically acceptable salt thereof as a starting material, resulting in good selectivity and yield. more preferably 0.8 to 1.5 molar equivalents.
  • the method of contacting the isothiazolinone compound (2) or a chemically acceptable salt thereof with the brominating agent is not particularly limited.
  • a brominating agent may be added to a chemically acceptable salt thereof and mixed using a stirring device such as a mechanical stirrer.
  • the bromination reaction can be carried out at a reaction temperature appropriately selected from the range of 0°C to the reflux temperature of the solvent, and from the viewpoint of good selectivity and yield, the reaction temperature is selected from the range of 0°C to 80°C. It is preferable to carry out at The reaction time may be, for example, 1 to 48 hours.
  • the 4-bromoisothiazolinone derivative (1) obtained by general post-treatment operations such as extraction and concentration may contain impurities.
  • Impurities include an unreacted raw material isothiazolinone compound (2) having similar chemical properties to the target 4-bromoisothiazolinone derivative (1) or a chemically acceptable salt thereof, as well as an isothiazolinone ring and a compound in which the 5-position of is brominated, and a compound in which the 4- and 5-positions are brominated.
  • NBS or DBH is used as a brominating agent, succinimide or 5,5-dimethylhydantoin may remain. Therefore, it is difficult to remove these impurities and obtain a highly purified target product at a high recovery rate by a general purification method.
  • Step b) is a step of purifying the 4-bromoisothiazolinone derivative (1) obtained by the bromination reaction. This is a step for obtaining the isothiazolinone derivative (1) at a high recovery rate.
  • the solvent used in step b it is preferable to use a halogen solvent, an ester solvent, an aromatic solvent, or the like.
  • halogen-based solvents include chloroform, dichloromethane, dichloroethane, and carbon tetrachloride.
  • ester solvents include methyl acetate, ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, tert-butyl acetate and the like.
  • aromatic solvents include toluene, xylene, chlorobenzene, o-dichlorobenzene, m-dichlorobenzene, nitrobenzene and the like.
  • chloroform, dichloromethane, carbon tetrachloride, ethyl acetate, propyl acetate, butyl acetate, isobutyl acetate, toluene, chlorobenzene or o-dichlorobenzene are preferred in terms of good yield (recovery), and ethyl acetate , chlorobenzene and o-dichlorobenzene are more preferred.
  • the conditions for recrystallization in step b) will be explained.
  • the 4-bromoisothiazolinone derivative (1) mixed with the solvent is dissolved by heating, and then cooled to precipitate the highly pure 4-bromoisothiazolinone derivative (1).
  • the amount of the solvent to be used is an amount appropriately selected from the range of, for example, 10% by weight to 1000% by weight with respect to the weight of the 4-bromoisothiazolinone derivative (1) obtained in step a).
  • 4-bromoisothiazolinone derivative (1) is preferably added in the minimum amount of solvent that completely dissolves it.
  • the temperature during heating can be appropriately selected from the range of 25° C. to the reflux temperature of the solvent. There is no particular limitation on the temperature for cooling, and although it may be cooled in an ice bath, it may be allowed to cool to room temperature (eg, 18 to 28°C).
  • High-purity 4-bromoisothiazolinone derivative (1) can be precipitated by suspending 4-bromoisothiazolinone derivative (1) in a solvent.
  • the amount of the solvent to be used is appropriately selected from the range of, for example, 10% by weight to 1000% by weight with respect to the weight of the 4-bromoisothiazolinone derivative (1) obtained in step a). be able to.
  • the suspension can be carried out at a reaction temperature appropriately selected, for example, from the range of -20°C to the reflux temperature of the solvent.
  • a highly pure 4-bromoisothiazolinone derivative (1) can be isolated by filtering the precipitated solid.
  • the method of filtration is not particularly limited, and for example, it may be carried out by appropriately selecting from natural filtration, vacuum filtration, centrifugal filtration, etc. according to the reaction scale and the like. Vacuum filtration and centrifugal filtration are preferred because they are efficient and can shorten the time.
  • step b The higher the purity of the 4-bromoisothiazolinone derivative (1) used in step b), the more efficiently a highly pure target product can be obtained.
  • NBS or DBH is used as the brominating agent
  • succinimide and 5,5-dimethylhydantoin generated from NBS and DBH, respectively are preferably removed as much as possible before recrystallization or slurry washing.
  • a method for removing these impurities for example, a method of washing the reaction mixture with a basic aqueous solution after completion of the bromination reaction can be exemplified.
  • Basic aqueous solutions include, for example, sodium acetate aqueous solution, potassium acetate aqueous solution, sodium hydroxide aqueous solution, potassium hydroxide aqueous solution, sodium carbonate aqueous solution, potassium carbonate aqueous solution, sodium hydrogen carbonate aqueous solution, potassium hydrogen carbonate aqueous solution, trisodium phosphate aqueous solution, An aqueous solution of tripotassium phosphate and the like can be mentioned.
  • step b) may be repeated until the 4-bromoisothiazolinone derivative (1) reaches the desired purity.
  • a method for producing a 4-bromoisothiazolinone derivative according to an embodiment of the present invention is a method for producing a 4-bromoisothiazolinone derivative useful as an active ingredient of a fungicide or an antibacterial agent with good selectivity, yield and purity. is useful as
  • a 4-bromoisothiazolinone derivative that can be produced with high yield and high purity by the method for producing a 4-bromoisothiazolinone derivative according to an embodiment of the present invention is useful as an active ingredient of a disinfectant and an antibacterial agent. It can be used in various fields such as industrial preservatives, building materials, paints, adhesives, leather, paper pulp, cooling towers, industrial oils, textiles, cleaning aids, cosmetics and household products.
  • the 4-bromoisothiazolinone derivative represented by the above formula (1) produced by the method for producing a 4-bromoisothiazolinone derivative according to an embodiment of the present invention is an isothiazolinone compound represented by the above formula (2) or its
  • the content of chemically acceptable salts is less than 100 ppm.
  • Formula (1) (Wherein, R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms.)
  • a method for producing a 4-bromoisothiazolinone derivative represented by formula (2) (Wherein R is the same as formula (1)), an isothiazolinone compound or a chemically acceptable salt thereof is brominated in an aqueous solvent or a mixed solvent of an aqueous solvent and an organic solvent.
  • [5] A method for producing a 4-bromoisothiazolinone derivative according to any one of [1] to [4], A method for producing a 4-bromoisothiazolinone derivative, wherein the amount of the water solvent used is in the range of 0.1 to 10 in weight ratio to the starting material.
  • [6] A method for producing a 4-bromoisothiazolinone derivative according to any one of [1] to [5], A method for producing a 4-bromoisothiazolinone derivative, wherein the brominating agent is bromine, N-bromosuccinimide, or 1,3-dibromo-5,5-dimethylhydantoin.
  • [7] A method for producing a 4-bromoisothiazolinone derivative according to any one of [1] to [6], A method for producing a 4-bromoisothiazolinone derivative, wherein the reaction temperature in the bromination is in the range of 0°C to 80°C.
  • [8] A method for producing a 4-bromoisothiazolinone derivative according to any one of [1] to [7], A method for producing a 4-bromoisothiazolinone derivative, wherein said R is an alkyl group having 1 to 4 carbon atoms.
  • a 4-bromoisothiazolinone derivative represented by formula (1) which is an isothiazolinone compound represented by formula (2) included in the 4-bromoisothiazolinone derivative, or a chemically acceptable salt thereof content is less than 100 ppm, 4-bromoisothiazolinone derivative.
  • R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms.
  • R is the same as in formula (1).
  • the composition and yield of crude products were determined by the 1 H-NMR internal standard method.
  • the 1 H-NMR internal standard method a predetermined amount of 1,4-di-tert-butylbenzene is added as an internal standard substance to the crude product, and chloroform or a mixed solution of chloroform and dimethylformamide is added to obtain a substantially homogeneous solution. A portion of this solution was sampled, diluted with deuterated chloroform, and subjected to 1 H-NMR measurement. From the integrated values in the obtained 1 H-NMR spectrum, the ratio of the target substance and starting material to the internal standard substance was calculated, and the composition and yield were determined.
  • Example 4 After adding water (2.30 g) to 2-methyl-4-isothiazolin-3-one (50 wt% aqueous solution, 2.00 g, 8.68 mmol), bromine (0.53 mL, 10.4 mmol) was added for 10 minutes. dripped over. This mixed solution was stirred at room temperature for 3 hours. After neutralizing the reaction solution by adding a 20 wt% aqueous sodium carbonate solution, it was extracted with ethyl acetate (15 mL x 3 times), and each organic layer was separated with a 1:1 mixture of 20 wt% sodium carbonate aqueous solution and saturated brine ( 2 mL each). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the desired crude product (1.60 g).
  • Example 7 After adding water (75.00 g) to 2-methyl-4-isothiazolin-3-one (50 wt% aqueous solution, 100.19 g, 435 mmol), bromine (27.0 mL, 524 mmol) was added over 2.5 hours. Dripped. This mixed solution was stirred at room temperature for 1 hour. A 20% by weight sodium carbonate aqueous solution was added to the reaction solution to neutralize it, then saturated brine (200 mL) was added, and the mixture was extracted with ethyl acetate (350 mL ⁇ 3 times). The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the desired crude product (78.57 g).
  • Example 8> After adding water (150.00 g) to 2-methyl-4-isothiazolin-3-one (50 wt% aqueous solution, 200.09 g, 869 mmol), bromine (54.0 mL, 1.05 mol) was added over 5 hours. Dripped. This mixed solution was stirred at room temperature for 1 hour. After neutralizing the reaction solution by adding a 20% by weight aqueous sodium carbonate solution, saturated brine (400 mL) was added, and the mixture was extracted with ethyl acetate (500 mL ⁇ 4 times). The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the desired crude product (159.33 g).
  • Example 9 After adding water (3.00 g) to 2-methyl-4-isothiazolin-3-one (50 wt% aqueous solution, 4.00 g, 17.4 mmol), bromine (1.07 mL, 20.9 mmol) was added at 40°C. was added dropwise over 10 minutes. This mixed solution was stirred at 40° C. for 2 hours. A saturated aqueous sodium carbonate solution was added to the reaction solution to neutralize it, saturated brine (8 mL) was added, and the mixture was extracted with ethyl acetate (20 mL ⁇ 3 times). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the desired crude product (3.14 g).
  • Example 11 After adding water (7.50 g) to 2-methyl-4-isothiazolin-3-one (50 wt% aqueous solution, 10.02 g, 43.5 mmol), bromine (2.70 mL, 52.4 mmol) was added for 45 minutes. dripped over. The mixed solution was stirred overnight (12 hours) at room temperature. A saturated sodium carbonate aqueous solution was added to the reaction solution to neutralize it, then a saturated saline solution (20 mL) was added, and the mixture was extracted with methyl isobutyl ketone (35 mL ⁇ 3 times). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the desired crude product (7.85 g).
  • Example 12 After adding water (7.50 g) to 2-methyl-4-isothiazolin-3-one (50 wt% aqueous solution, 10.02 g, 43.5 mmol), bromine (2.70 mL, 52.4 mmol) was added for 45 minutes. dripped over. The mixed solution was stirred overnight at room temperature. A saturated sodium carbonate aqueous solution was added to the reaction solution to neutralize it, then a saturated saline solution (20 mL) was added, and the mixture was extracted with chlorobenzene (35 mL ⁇ 3 times). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the desired crude product (7.57 g).
  • Example 13> After adding water (7.50 g) to 2-methyl-4-isothiazolin-3-one (50 wt% aqueous solution, 10.03 g, 43.5 mmol), bromine (2.70 mL, 52.4 mmol) was added for 45 minutes. dripped over. The mixed solution was stirred overnight at room temperature. A saturated aqueous sodium carbonate solution was added to the reaction solution for neutralization, then saturated brine (20 mL) was added, and the mixture was extracted with o-dichlorobenzene (35 mL ⁇ 3 times). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the desired crude product (7.53 g).
  • Example 17 After adding water (10.0 g) to 2-methyl-4-isothiazolin-3-one (50 wt% aqueous solution, 10.11 g, 43.9 mmol), bromine (2.75 mL, 53.3 mmol) in chlorobenzene ( 20.0 mL) solution was added dropwise over 30 minutes. The mixed solution was stirred overnight at room temperature. Saturated saline (50 mL) was added to the reaction solution, which was then neutralized with a saturated aqueous sodium carbonate solution and then extracted with chlorobenzene (50 mL x 4 times). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the desired crude product (8.06 g).
  • Example 18 After adding water (1.00 g) to 2-methyl-4-isothiazolin-3-one (50 wt% aqueous solution, 2.02 g, 8.75 mmol), bromine (0.54 mL, 10.5 mmol) in chlorobenzene ( 4.0 mL) solution was added dropwise over 30 minutes. The mixed solution was stirred overnight at room temperature. Saturated saline (10 mL) was added to the reaction solution, which was then neutralized with a saturated aqueous sodium carbonate solution and then extracted with chlorobenzene (10 mL x 4 times). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the desired crude product (1.61 g).
  • Example 19 After adding water (2.00 g) to 2-methyl-4-isothiazolin-3-one (50 wt% aqueous solution, 2.03 g, 8.81 mmol), o- Dichlorobenzene (4.0 mL) solution was added dropwise over 30 minutes. This mixed solution was stirred at room temperature for 6 hours. Saturated saline (10 mL) was added to the reaction solution, which was then neutralized with saturated aqueous sodium carbonate solution and then extracted with o-dichlorobenzene (10 mL ⁇ 4 times). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the desired crude product (1.86 g).
  • Example 20 After adding water (4.40 g) to 2-methyl-4-isothiazolin-3-one (50 wt% aqueous solution, 2.02 g, 8.75 mmol), bromine (0.54 mL, 10.5 mmol) was added for 10 minutes. dripped over. This mixed solution was stirred at room temperature for 3 hours. A saturated aqueous sodium carbonate solution was added to the reaction solution to neutralize it, saturated brine (10 mL) was added, and the mixture was extracted with ethyl acetate (10 mL ⁇ 4 times). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the desired crude product (1.66 g). As a result of analysis by 1 H-NMR internal standard method, the composition and yield were as follows. Table 1 shows the results.
  • Example 21 After adding water (2.00 g) to 2-methyl-4-isothiazolin-3-one (50 wt% aqueous solution, 2.02 g, 8.78 mmol), bromine (0.54 mL, 10.5 mmol) in chlorobenzene ( 4.0 mL) solution was added dropwise over 30 minutes. The mixed solution was stirred overnight at room temperature. A saturated sodium carbonate aqueous solution was added to the reaction solution to neutralize it, then a saturated saline solution (10 mL) was added, and the mixture was extracted with chlorobenzene (10 mL ⁇ 4 times). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the desired crude product (1.62 g). As a result of analysis by 1 H-NMR internal standard method, the composition and yield were as follows. Table 1 shows the results.

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Abstract

L'invention concerne un procédé de production sélective d'un dérivé de 4-bromoisothiazolinone de pureté élevée avec un bon rendement. L'invention concerne un procédé de production d'un dérivé de 4-bromoisothiazolinone représenté par la formule (1) (dans laquelle R représente un atome d'hydrogène ou un groupe alkyle en C1 à C12). Le procédé implique l'utilisation d'un agent de bromation pour la bromation d'un composé d'isothiazolinone représenté par la formule (2) (dans laquelle R est le même que dans la formule (1)) ou d'un sel chimiquement acceptable de celui-ci dans un solvant aqueux ou un solvant mixte d'un solvant aqueux et d'un solvant organique.
PCT/JP2022/030945 2021-09-02 2022-08-16 Procédé de production d'un dérivé de 4-bromoisothiazolinone, et dérivé de 4-bromoisothiazolinone WO2023032654A1 (fr)

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