WO2022239033A1 - Compositions antimicrobiennes contenant du zinc inorganique pour le cuir et d'autres surfaces sensibles - Google Patents

Compositions antimicrobiennes contenant du zinc inorganique pour le cuir et d'autres surfaces sensibles Download PDF

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Publication number
WO2022239033A1
WO2022239033A1 PCT/IN2022/050462 IN2022050462W WO2022239033A1 WO 2022239033 A1 WO2022239033 A1 WO 2022239033A1 IN 2022050462 W IN2022050462 W IN 2022050462W WO 2022239033 A1 WO2022239033 A1 WO 2022239033A1
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Prior art keywords
zinc
composition
acid
component
antimicrobial
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PCT/IN2022/050462
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English (en)
Inventor
Prerna Goradia
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Prerna Goradia
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Publication of WO2022239033A1 publication Critical patent/WO2022239033A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof

Definitions

  • the present invention broadly relates to environmentally friendly fungicidal disinfectants. More particularly, the invention relates to non-toxic antimicrobial compositions and methods for protecting items of plant and / or animal origin, in particular, protecting them against degradation resulting from microbiological growth.
  • leather is a sturdy and supple material created by tanning animal skins and raw hide.
  • the animal hides received by tanneries can be used for valuable end products, but such hides are susceptible to decomposition by microorganisms. Microbial growth on the hide surface and within the hide and blood vessels may cause irreparable damage resulting in lower quality hides having reduced value. Damaged hides may display holes or darkened areas, reduced hide strength, and altered stretching characteristics where all measures of hide quality are adversely affected by microbial growth.
  • US 10034478 relates to compositions having antimicrobial activity with surface functionalized particles comprising an inorganic copper salt which has low water solubility. These types of inorganic salts may also be introduced in porous particles to yield antimicrobial compositions.
  • the compositions may optionally comprise additional antimicrobial agents, salts with high water solubility, organic acids, salts of organic acids and their esters.
  • WO2010127335 relates to the field of antimicrobial formulations, and more specifically, to an antimicrobial formulation comprising zinc pyrithione in a stabilized dispersion.
  • Zinc pyrithione in this composition is an organic compound which is toxic for prolonged usage whereas Zinc chloride in the present invention is a non toxic inorganic chemical.
  • EP0932704 relates to compositions containing polyether antibiotics having reduced particle size and surface-acting agents are useful for protecting untanned animal hides against decomposition for up to 96 hours when stored at ambient temperature. Further processing of treated hides presents no environmental hazards.
  • the present invention is useful in the preservation of hide quality of a wide variety of animals useful for tanning.
  • US 10542756 relates to a method of treating a textile substrate by applying a disinfecting treating composition comprising at least one anti -microbial agent, using an exhaust process, and subjecting the textile substrate to one or more heat treatments.
  • JP6833836 relates to novel bactericidal and fungicidal compositions, especially their use in agriculture or horticulture to control diseases caused by phytopathogens such as phytopathogens, and especially useful plant diseases such as fruits and vegetables.
  • the prior art comprises of surfactants and carriers for making the said compositions whereas the present invention is a simple composition without the requirement of any such additives.
  • KR101918417 relates to a method for manufacturing a leather fabric excellent in antimicrobial properties by using zinc zeolite and a technology of utilizing the same as a material for shoes.
  • the antimicrobial leather produced by the method according to the present invention is an environmentally friendly leather fabric which can fundamentally block causes of foot odor and malodor due to bacteria and dermatophytes or sweat after intense exercise and can be effectively used as a material for shoes.
  • the zeolite composition of the said invention is a complex of aluminum, silicon, zinc powder and Syntan, whereas the present invention is a non toxic aqueous composition comprising of zinc and other antimicrobials.
  • JP5912812 relates to a disinfectant composition for textiles of the present invention exhibits an excellent disinfecting effect without being affected by the hardness of water used for dilution or formulation and a method for sterilizing a textile product, wherein a treatment liquid prepared from the microbicide composition for textile products of the present invention and containing the component (B) containing 5 ppm or more and 100,000 ppm or less is brought into contact with the textile product.
  • ZnO Nanoparticles for Antimicrobial Treatment of Leather Surface have disclosed the antimicrobial performances of leather surfaces treated with ZnO nanoparticles as alternative to the use of volatile organic biocide materials, where the hydrothermal synthesis of ZnO nanoparticles is described as an efficient and easy to control method compared to sol-gel methods.
  • the ZnO nanoparticles were uniformly dispersed on leather surface by conventional technologies based on sprayed layers and were available for direct contact with bacteria and fungi.
  • ZnO in the prior art is a white solid that is insoluble in water, whereas the composition in the present invention is a clear water soluble formulation.
  • the present invention addresses the need to preserve products from these sources without any damage and eradicate the adverse environmental and economical impacts associated with the use of other agents and processes.
  • the present invention is an inorganic aqueous composition of zinc, which is non-toxic to the environment and has longer stability.
  • the present invention attempts to overcome the problems faced in the prior art, and discloses a non toxic and cost-efficient composition for treating the leather, rubber and soft materials such as industrial textiles as well as methods of treating the hides using the composition.
  • the present invention relates to non-toxic antimicrobial compositions and methods for protecting items of plant and / or animal origin, in particular, protecting them against degradation resulting from microbiological growth. Further for production of skin-contact materials there is need for a leather processing method that can impart antimicrobial properties to remove harmful bacteria, fungi, viruses and the like, which proliferate in sweat or secretions of the human body, and cause foul odors. Moreover, the compositions can be used for any surface that is prone to microbial attack such as leather, rubber or any such material or plant/animal origin.
  • the present invention discloses an aqueous antimicrobial composition having fungicidal activity comprising: (a) at least one component A containing 10-50 % (weight/V) of zinc salt; and (b) at least two other component B, selected from a group comprising mild organic acid, antimicrobial transition metals, alcohols and combinations thereof; and (c) at least one component C.
  • component A is selected from a group of zinc salt comprising zinc acetate, zinc sulphate, zinc nitrate, zinc chlorate, zinc sulfate, zinc phosphate, zinc molybdate, zinc chromate, zinc ricinoleate, zinc acetate, zinc chloride and combinations thereof.
  • mild organic acid of component B is selected from a group of carboxylic acids such as citric acid, acetic acid, long chain carboxylic acids/fatty acid such as oleic acid, lactic acid, linoleic acids and their salts, ascorbic acid and combinations thereof, but not limited to.
  • at least a component C is selected from a group of polymers comprising monometh (acrylates) such as HEMA and HEA, peg diacrylates, PVP, poly vinyl alcohol, water soluble polymers, and combinations thereof.
  • the present invention discloses a method for preparation of antimicrobial composition having fungicidal activity comprising the steps: (a) adding component, A containing at least 10-50% (weight/V) zinc salt and at least one component B, in aqueous solvent at room temperature; (b) spiking the mixture from step (a) with a transition metal salt comprising of at least one silver or copper salt, wherein the composition may be stabilized with a chelating mixture; and (c) adding a small amount of water-soluble carrier agent to the composition from step (b) which in turn helps in adhering the formulation to the surface of the articles; wherein a polar solvent is added at the last step to make the composition a fast-drying composition.
  • the present invention discloses a method with at least one component B comprises of at least one acid with a room temperature water solubility of greater than 1 g/liter selected from a group of carboxylic acids such as citric acid, acetic acid, long chain carboxylic acids/fatty acid such as oleic acid, lactic acid, linoleic acids and their salts, ascorbic acid and combinations thereof, but not limited to.
  • carboxylic acids such as citric acid, acetic acid, long chain carboxylic acids/fatty acid such as oleic acid, lactic acid, linoleic acids and their salts, ascorbic acid and combinations thereof, but not limited to.
  • At least one carrier molecule for cross linking is selected from a group of polymers comprising monometh (acrylates) such as HEMA and HEA, peg diacrylates, PVP, poly vinyl alcohol, water soluble polymers, and combinations thereof.
  • the transition metal salt is selected from a group of at least one silver or copper salt comprising silver acetate, silver nitrate, copper sulfate, silver citrate and combination thereof.
  • the present invention discloses an invention where at least one alcohol selected from a group comprising isopropanol, ethanol, polar solvents(turpentine), ethyl acetate and combinations thereof, is optionally added at the last step for limiting the moisture on the article surfaces which can harbor further micro-organisms.
  • the composition is in the form of aerosols, infusions, sprays, mist, drops, or one or more liquids additive formulations or spray dried to generate a powdered form, but not limited to.
  • the composition may be added as an additive to the tanning process of leather for preparing fungal resistant leather composites and the inorganic salts in the composition are embedded in the upper layers of the leather/ soft natural material and synthetic material, in turn providing a long-lasting effect.
  • the present invention discloses an antimicrobial composition wherein the acid is added to make the formulation a colorless solution since the Zinc oxy-chloride species is not very soluble. Being a colorless solution, the formulation does not leave unsightly white marks on the objects.
  • the pH of the solution is slightly acidic.
  • the present invention discloses an antimicrobial composition wherein the said composition has antimicrobial activity by release of ions from the said salt or a matrix in which the said components are incorporated when it comes in contact with the microbial milieu.
  • the invention further discloses a process of adding the antimicrobial formulation to the tanning process of leather for preparing fungal resistant leather composites. Since the salts are mainly inorganic, thereby getting embedded in the upper layers of the leather/ soft objects and thus in the process providing a long-lasting effect.
  • the present invention relates to an antimicrobial formulation, comprising an aqueous solution of zinc compounds and other additives wherein the ions are released in the aqueous solution and provide an extremely eco-friendly and safe on skin fungicidal composition with no foul odor.
  • Fig. 1 illustrates the typical zone of inhibition in anti microbial study for formulation P009, in accordance with an embodiment of the present invention
  • Fig. 2 illustrates the growth of A.Niger in ASTM D476 test results in control/untreated and P009 formulation treated sample plates after 3 days and 14 days of treatment with the formulation, in accordance with an embodiment of the present invention
  • FIG. 3 illustrates the typical zone of inhibition in anti microbial study for formulation P34, in accordance with an embodiment of the present invention.
  • Fig. 4 illustrates the image of leather footwear showing absence of any mold growth after treatment with the anti microbial composition as compared to the untreated footwear, in accordance with an embodiment of the present invention.
  • the present invention relates to a nontoxic and cost efficient composition for treating the leather and other soft and porous surfaces as well as methods of treating the hides using the composition.
  • the present invention discloses an aqueous antimicrobial composition having fungicidal activity comprising: (a) at least one component A containing 10-50 % (weight/V) of zinc salt; and (b) at least two other component B, selected from a group comprising mild organic acid, antimicrobial transition metals, alcohols and combinations thereof; and (c) at least one component C.
  • component A is selected from a group of zinc salt comprising zinc acetate, zinc sulphate, zinc nitrate, zinc chlorate, zinc sulfate, zinc phosphate, zinc molybdate, zinc chromate, zinc ricinoleate, zinc acetate, zinc chloride and combinations thereof.
  • mild organic acid of component B is selected from a group of carboxylic acids such as citric acid, acetic acid, long chain carboxylic acids/fatty acid such as oleic acid, lactic acid, linoleic acids and their salts, ascorbic acid and combinations thereof, but not limited to.
  • carboxylic acids such as citric acid, acetic acid, long chain carboxylic acids/fatty acid such as oleic acid, lactic acid, linoleic acids and their salts, ascorbic acid and combinations thereof, but not limited to.
  • At least one component C is selected from a group of polymers comprising monometh (acrylates) such as HEMA and HEA, peg diacrylates, PVP, poly vinyl alcohol, water soluble polymers, and combinations thereof.
  • the present invention discloses a method for preparation of antimicrobial composition having fungicidal activity comprising the steps: (a) adding component, A containing at least 10-50% (weight/V) zinc salt and at least one component B, in aqueous solvent at room temperature; (b) spiking the mixture from step (a) with a transition metal salt comprising of at least one silver or copper salt, wherein the composition is stabilized with a chelating mixture; and (c) adding a small amount of water-soluble carrier agent to the composition from step (b) which in turn helps in adhering the formulation to the surface of the articles; wherein a polar solvent is added at the last step to make the composition a fast-drying composition.
  • the present invention discloses a method with at least one component B comprises of at least one acid with a room temperature water solubility of greater than 1 g/liter selected from a group of carboxylic acids such as citric acid, acetic acid, long chain carboxylic acids/fatty acid such as oleic acid, lactic acid, linoleic acids and their salts, ascorbic acid and combinations thereof, but not limited to.
  • carboxylic acids such as citric acid, acetic acid, long chain carboxylic acids/fatty acid such as oleic acid, lactic acid, linoleic acids and their salts, ascorbic acid and combinations thereof, but not limited to.
  • At least one carrier molecule for cross linking is selected from a group of polymers comprising monometh (acrylates) such as HEMA and HEA, peg diacrylates, PVP, poly vinyl alcohol, water soluble polymers, and combinations thereof.
  • the transition metal salt is selected from a group of at least one silver or copper salt comprising silver acetate, silver nitrate, copper sulfate, silver citrate and combination thereof.
  • the present invention discloses an invention where at least one alcohol selected from a group comprising isopropanol, ethanol, polar solvents(turpentine), ethyl acetate and combinations thereof, is optionally added at the last step for limiting the moisture on the article surfaces to reduce the further growth of micro-organisms.
  • the composition is in the form of aerosols, infusions, sprays, mist, drops, or one or more liquids additive formulations or spray dried to generate a powdered form, but not limited to.
  • the composition is optionally added as an additive to the tanning process of leather for preparing fungal resistant leather composites and the inorganic salts in the composition are embedded in the upper layers of the leather/ soft natural material and synthetic material, in turn providing a long-lasting effect.
  • the present invention discloses an antimicrobial composition wherein the acid is added to make the formulation a colorless solution since the Zinc oxy-chloride species is not very soluble. Being a colorless solution, the formulation does not leave unsightly white marks on the objects.
  • the pH of the solution is slightly acidic.
  • the present invention discloses an antimicrobial composition wherein the said composition has antimicrobial activity by release of ions from the said salt or a matrix in which the said components are incorporated when it comes in contact with the microbial milieu.
  • the mild acids and transition metals in the composition are for imparting additional antimicrobial activity.
  • the invention further discloses a process of adding the antimicrobial formulation to the tanning process of leather for preparing fungal resistant leather composites. Since the salts are mainly inorganic, thereby getting embedded in the upper layers of the leather/ soft objects and thus in the process providing a long-lasting effect.
  • the present invention relates to an antimicrobial formulation, comprising an aqueous solution of zinc compounds and other additives wherein the ions are released in the aqueous solution and provide an extremely eco-friendly and safe on skin fungicidal composition with no foul odor.
  • the invention further discloses environmental friendly, non-toxic antimicrobial compositions and methods for protecting items of plant and / or animal origin, in particular, protecting them against degradation resulting from microbiological growth.
  • the said formulation is colorless, odorless, with a near neutral pH and formulates well during the tanning process of leather. It is also available in a powder form and is effective against a wide range of microorganisms .
  • Example 1 Microbiological studies: The zone of inhibition antimicrobial study was done to test the efficacy of the formulations. ASTM D4576 test was done to determine the mold growth resistance of Wet Blue and Wet White subject to storage and shipping requirements and intended for use in leather manufacturing.
  • Table 1 Table showing the Zone of Inhibition anti microbial activity data of different formulations.
  • Example 2 In another experiment for studying the antifungal activity, a pair of leather footwear was examined for microbial growth, with and without treatment with the antimicrobial composition (Zinc with acetic acid and water). In this, one shoe was sprayed with the antifungal composition (100ml or less) on both the sides of the shoe, by covering the entire leather. The treated and the non- treated piece of leather shoe both were exposed to high humidity and temperature (90 Relative Humidity, 35°C) for the first 5 days after which they were sealed in plastic bag and fungal growth was monitored for 3rd day, 7th day and 14th day. No fungal molds were observed in the treated piece of leather shoe even after 5 days, whereas untreated sample was covered with micelle even on day 3; thereby showing the antifungal activity of the composition (Table 4) (Table 2).
  • compositions having compounds of zinc thus, can kill bacteria, viruses and fungus that evolve in the leather products or animal hides, on contact due to the antimicrobial properties of zinc ions.
  • formulations can be further utilized on textile surfaces as efficient surface disinfectant. The antimicrobial formulations being gentle enough provide an unparalleled combination of high efficiency, environment friendly and low toxicity with instant kill and long term efficacy.
  • the present invention is to provide a big change in the leather industry. This is an aqueous, easy to be dosed stand alone preservative and disinfectant, for many formulations. It is an effective alternative to TCMTB, with high bioavailability in the water phase.
  • the highly water-soluble antimicrobial formulation can be incorporated into the process of tanning of leather, or fungicidal solution for spraying on the articles to protect it from the fungal attacks or mold growth.
  • composition can be added to alginate based plastic films as well.
  • compositions can be used not only as a spray but can be used as a component in as an antimicrobial additive.

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  • Life Sciences & Earth Sciences (AREA)
  • Plant Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • General Chemical & Material Sciences (AREA)
  • Treatment And Processing Of Natural Fur Or Leather (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Agronomy & Crop Science (AREA)
  • Inorganic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Abstract

L'invention concerne des compositions antimicrobiennes non toxiques et des procédés pour protéger des articles d'origine végétale et/ou animale, en particulier pour les protéger contre la dégradation résultant d'une croissance microbiologique. Pour la production de matériaux qui peuvent entrer en contact avec la peau, il existe un besoin pour un procédé de traitement du cuir capable de conférer des propriétés antimicrobiennes pour éliminer les bactéries, les champignons, les virus et autres éléments nuisibles qui prolifèrent dans la sueur ou les sécrétions du corps humain et provoquent de mauvaises odeurs. L'invention concerne des compositions aqueuses incolores non toxiques, économiques et écologiques de zinc, dopées à l'argent et aux polymères hydrosolubles et leur procédé de préparation.
PCT/IN2022/050462 2021-05-12 2022-05-12 Compositions antimicrobiennes contenant du zinc inorganique pour le cuir et d'autres surfaces sensibles WO2022239033A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN202121021563 2021-05-12
IN202121021563 2021-05-12

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WO2022239033A1 true WO2022239033A1 (fr) 2022-11-17

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB916665A (en) * 1958-06-02 1963-01-23 Yardley Internat Corp Process and material for the antimicrobial treatment of organic matter
US20150373989A1 (en) * 2011-05-24 2015-12-31 Agienic, Inc. Antimicrobial articles of manufacture

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB916665A (en) * 1958-06-02 1963-01-23 Yardley Internat Corp Process and material for the antimicrobial treatment of organic matter
US20150373989A1 (en) * 2011-05-24 2015-12-31 Agienic, Inc. Antimicrobial articles of manufacture

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