WO2022234737A1 - Produit cosmétique émulsifié de type huile dans l'eau - Google Patents

Produit cosmétique émulsifié de type huile dans l'eau Download PDF

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WO2022234737A1
WO2022234737A1 PCT/JP2022/013232 JP2022013232W WO2022234737A1 WO 2022234737 A1 WO2022234737 A1 WO 2022234737A1 JP 2022013232 W JP2022013232 W JP 2022013232W WO 2022234737 A1 WO2022234737 A1 WO 2022234737A1
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oil
less
cosmetic
shaped structure
disc
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PCT/JP2022/013232
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English (en)
Japanese (ja)
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啓 渡辺
允人 宇山
マチユ バンクトウー
治男 島田
祐仁 伊東
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株式会社 資生堂
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Priority to JP2023518635A priority Critical patent/JPWO2022234737A1/ja
Priority to CN202280027624.5A priority patent/CN117120019A/zh
Publication of WO2022234737A1 publication Critical patent/WO2022234737A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present disclosure relates to oil-in-water emulsified cosmetics.
  • oil-in-water emulsion compositions that can be used in cosmetics are prepared using emulsifiers.
  • various emulsifiers have been developed in order to obtain oil-in-water emulsion compositions with excellent emulsion stability.
  • Patent Document 1 discloses an oil-in-water emulsified composition prepared using an emulsifying dispersant whose main component is a closed endoplasmic reticulum (vesicle) formed by an amphiphilic substance with self-organizing ability.
  • oil-in-water emulsified cosmetics in addition to emulsifiers (surfactants), various materials such as oils, thickeners, and moisturizers are used.
  • emulsifiers surfactants
  • various materials such as oils, thickeners, and moisturizers are used.
  • oil-in-water emulsified cosmetics it has been desired to increase the variety of emulsifiers so that such materials can be used as appropriate.
  • the subject of the present disclosure is to provide an oil-in-water emulsified cosmetic prepared using a novel emulsifier and having excellent emulsion stability.
  • An oil-in-water emulsified cosmetic comprising The oil droplets contain oil and a disc-shaped structure, The disk-shaped structure is formed by laminating monomolecular films having a hydrophilic portion and a lipophilic portion, and is arranged at the interface between the oil droplet and the aqueous phase.
  • the oil is at least one selected from the group consisting of polar oils and silicone oils.
  • an oil-in-water emulsified cosmetic prepared using a novel emulsifier and having excellent emulsion stability.
  • FIG. 2 is a schematic diagram showing the state of arrangement of disk-shaped structures at the interface between oil droplets and the aqueous phase of the oil-in-water emulsified cosmetic according to one embodiment of the present disclosure.
  • the oil-in-water emulsified cosmetic of the present disclosure includes a dispersion medium containing water and oil droplets dispersed in the dispersion medium, the oil droplets including oil and disk-shaped structures, and the disk-shaped structures are , a monomolecular film having a hydrophilic portion and a lipophilic portion are laminated to each other and arranged at the interface between the oil droplet and the water phase.
  • the disc-shaped structure functions as an emulsifier, and the principle of action for obtaining an oil-in-water emulsified cosmetic with excellent emulsion stability is as follows. I think that it is as follows.
  • the disc-shaped structure of the present disclosure is composed of two vesicles formed by vesicles formed in the aqueous phase, for example, collapsing under the influence of oil in the cosmetic.
  • the bilayer membrane that constitutes the vesicle via the hydrophilic part of the monomolecular film or the monomolecular membranes forming the bilayer membrane of the vesicle are laminated with the hydrophilic portions interposed therebetween or with the lipophilic portions interposed therebetween.
  • the disc-shaped structure is formed of a monomolecular film having a hydrophilic portion and a lipophilic portion that constitute the bilayer of the vesicle.
  • the lipophilic portion hydrophobic portion
  • the hydrophilic portion is arranged at the interface with the water phase, so that the laminate as a whole is similar to an emulsifier. I think it can work.
  • a monomolecular film having a hydrophilic portion and a lipophilic portion itself has the ability to emulsify oil. Therefore, when this monomolecular film material is used as an emulsifier to emulsify water and oil, the monomolecular film material does not stack in a layered manner, and the oil droplets and the aqueous phase are not laminated in the same way as common emulsifiers. is thought to be oriented near the interface of Under such conditions, the material of the monolayer generally does not remain near the interface with the aqueous phase in the oil droplets (emulsified particles), e.g., in the aqueous phase or at the interface of other adjacent oil droplets. is considered to be in an equilibrium state in which the As a result, the oil is exposed at the interface of the oil droplets, and tends to aggregate and coalesce with the oil in other adjacent oil droplets, which is likely to reduce the emulsion stability.
  • a monomolecular film having a hydrophilic portion and a lipophilic portion is arranged in the form of a disk-shaped structure laminated in layers at the interface between the oil droplets and the aqueous phase.
  • this disc-shaped structure is thought to have reduced or suppressed migration in the aqueous phase or at the interface of other adjacent oil droplets, compared to common emulsifiers.
  • the oil is less likely to be exposed at the interface of the oil droplets and less likely to aggregate and coalesce with the oil in other adjacent oil droplets, thus improving the emulsification stability.
  • the oil-in-water emulsified cosmetic containing the disc-shaped structure of the present disclosure can also improve the occlusion effect (the effect of preventing moisture from escaping from the skin) as an incidental effect. This is because when the cosmetic of the present disclosure is applied to the skin, the disc-shaped structures in the cosmetic are arranged so as to cover the skin surface, so evaporation of moisture from the skin can be reduced or prevented. I think it's for the sake of
  • oil-in-water emulsified cosmetic containing the disk-shaped structure of the present disclosure can improve permeation feeling, moist feeling, usability (stickiness resistance), film resistance feeling, etc. as additional effects. .
  • the emulsifying dispersant described in Patent Document 1 uses the vesicle itself, which is a closed endoplasmic reticulum, as an emulsifier, and is different from the disc-shaped structure in the present disclosure.
  • the term “disc-shaped structure” does not form a closed endoplasmic reticulum structure like a vesicle, and the cross-sectional shape of such a structure is substantially plate-shaped as shown in FIG. (eg, generally square, generally rectangular) are contemplated.
  • the term “substantially” means that the cross-sectional shape of such a structure is not allowed to be spherical like a vesicle, but is deformed to some extent, for example, deformed so as to exhibit a curvature along the shape of an oil droplet. is intended to be acceptable.
  • Liposomes in the present disclosure also include liposomes and polymersomes.
  • the dispersion medium (aqueous phase) in the oil-in-water emulsified cosmetic of the present disclosure (sometimes simply referred to as “cosmetics”) contains water.
  • the amount of water to be blended is not particularly limited, and for example, from the viewpoint of emulsion stability, 20% by mass or more, 30% by mass or more, 40% by mass or more, 50% by mass or more, and 60% by mass of the total amount of the cosmetic. 70% by mass or more, or 80% by mass or more, and 90% by mass or less, 80% by mass or less, 70% by mass or less, 60% by mass or less, or 50% by mass or less .
  • the water that can be used in the oil-in-water emulsified cosmetic of the present disclosure is not particularly limited, and for example, water used in cosmetics and quasi-drugs can be used.
  • water used in cosmetics and quasi-drugs can be used.
  • deionized water, distilled water, ultrapure water, and tap water can be used.
  • the oil droplets as the oil phase or dispersed phase in the oil-in-water emulsified cosmetic of the present disclosure contain an oil component and a disc-shaped structure.
  • the average particle size of the oil droplets can be, for example, 10 ⁇ m or less, 7 ⁇ m or less, 5 ⁇ m or less, or 3 ⁇ m or less immediately after production.
  • the lower limit of the average particle diameter is not particularly limited, it can be, for example, 500 nm or more, 700 nm or more, or 1 ⁇ m or more.
  • the average particle diameter of the oil droplets can be defined as the average value of the projected area circle equivalent diameters of 10 or more, preferably 100 or more oil droplets observed with an optical microscope.
  • oil content in the oil-in-water emulsion cosmetic of the present disclosure is 1.0% by mass or more, 2.0% by mass or more, 3.0% by mass or more, and 5.0% by mass with respect to the total amount of the cosmetic. 7.0% by mass or more, 10% by mass or more, 15% by mass or more, 20% by mass or more, 25% by mass or more, or 30% by mass or more, and 50% by mass or less, 45% by mass or more 40% by mass or less, 35% by mass or less, 30% by mass or less, 25% by mass or less, 20% by mass or less, 15% by mass or less, or 10% by mass or less.
  • the oil content is preferably 45% by mass or less, more preferably 40% by mass or less, relative to the total amount of the cosmetic, from the viewpoint of emulsion stability and the like.
  • oils for example, volatile and non-volatile oils can be used.
  • An oil component can be used individually or in combination of 2 or more types.
  • volatile is intended to exhibit a volatile content of more than 5% when left at 105°C under atmospheric pressure for 3 hours.
  • the volatile content which is a guideline for volatility, can be 10% or more, 20% or more, 40% or more, 50% or more, 60% or more, 80% or more, or 100%.
  • the boiling point at 1 atmosphere (101.325 kPa) can be used as an indicator of volatility.
  • the boiling point can be 250° C. or lower, 240° C.
  • non-volatile intends to exhibit a volatile content of 5% or less when left at 105°C for 3 hours.
  • the volatile oil is not particularly limited, and examples include volatile silicone oil and volatile hydrocarbon oil. Among these, volatile silicone oils are preferable from the viewpoint of reducing the average particle size of oil droplets.
  • a volatile oil can be used individually or in combination of 2 or more types.
  • Volatile silicone oils include, for example, volatile acyclic silicone oils and volatile cyclic silicone oils.
  • volatile acyclic silicone oils for example, volatile linear silicone oils and volatile branched silicone oils can be used.
  • Volatile linear silicone oils include, for example, dimethylpolysiloxane with a viscosity of 0.65 cs (sometimes referred to as “dimethicone"), dimethylpolysiloxane with a viscosity of 1 cs, dimethylpolysiloxane with a viscosity of 1.5 cs, and dimethylpolysiloxane with a viscosity of 2 cs. and low-molecular-weight linear dimethylpolysiloxane such as dimethylpolysiloxane.
  • dimethylpolysiloxane having a viscosity of 2 cs is more preferable from the viewpoint of reducing the average particle size of oil droplets.
  • these viscosities are intended to be kinematic viscosities at 25°C.
  • Volatile branched silicone oils include, for example, low-molecular-weight branched siloxanes such as methyltrimethicone, tris(trimethylsilyl)methylsilane, and tetrakis(trimethylsilyl)silane.
  • Volatile cyclic silicone oils include, for example, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane.
  • Volatile hydrocarbon oils include, for example, heptane, isododecane, isohexadecane, and isodecane.
  • oils include oils commonly used in cosmetics, such as liquid oils, solid oils, waxes, hydrocarbon oils other than those mentioned above, silicone oils other than those mentioned above, and polar oils. can be done. Among these, silicone oil is preferable from the viewpoint of reducing the average particle size of oil droplets.
  • some UV absorbers act as oils, especially polar oils. Such ultraviolet absorbers can also be regarded as oils.
  • liquid oils examples include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, and linseed oil. , safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, sinagi oil, Japanese pear oil, jojoba oil, germ oil, and triglycerin.
  • solid fats and oils examples include cacao butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, mutton tallow, hydrogenated beef tallow, palm kernel oil, lard, beef bone fat, Japanese wax kernel oil, hydrogenated oil, beef Leg fat, Japanese wax, and hydrogenated castor oil.
  • Waxes include, for example, beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, wart wax, whale wax, montan wax, bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, isopropyl lanolin fatty acid, hexyl laurate, Reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, and POE hydrogenated lanolin alcohol ether.
  • hydrocarbon oils examples include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, and olefin oligomers.
  • squalane is preferable from the viewpoint of emulsion stability.
  • silicone oils examples include linear silicones such as dimethylpolysiloxane (dimethicone), methylphenylpolysiloxane (diphenylsiloxyphenyltrimethicone), and methylhydrogenpolysiloxane having a viscosity of 6 cs or more.
  • polar oil for example, a polar oil with an IOB of 0.10 or more can be used.
  • a ultraviolet absorber can be used individually or in combination of 2 or more types.
  • the IOB value of the polar oil and UV absorber can be, for example, 0.11 or more, 0.12 or more, or 0.13 or more, and 0.50 or less, 0.45 or less, or 0.40 or less.
  • the IOB value is an abbreviation for Inorganic/Organic Balance (inorganic/organic ratio), which is a value representing the ratio of the inorganic value to the organic value, and is an index indicating the degree of polarity of an organic compound. It becomes.
  • polar oils are at least one selected from the group consisting of polar oils and silicone oils.
  • the polar oil is at least one polyglycerin fatty acid ester having an OH/C ratio of 0.30 to 0.60, preferably 0.35 to 0.60, more preferably 0.40 to 0.60, which will be described later.
  • the average oil droplet size can be reduced.
  • silicone oil is also advantageous as it can reduce the average particle size of the oil droplets.
  • the disc-shaped structure of the present disclosure which is a novel emulsifier, is formed by laminating monomolecular films having a hydrophilic portion and a lipophilic portion, and is arranged at the interface between the oil droplet and the aqueous phase. .
  • the number of laminated monomolecular films can be 3 or more, or 5 or more.
  • the upper limit of the number of layers to be laminated is not particularly limited, and may be, for example, 15 layers or less, 13 layers or less, 11 layers or less, 9 layers or less, or 7 layers or less.
  • the maximum length of one side of the cross-sectional shape of the disk-shaped structure for example, the length in the width direction of the disk-shaped structure in FIG. or less, or 30 nm or more, 40 nm or more, or 50 nm or more.
  • the maximum length is intended to be the length of the curved surface as shown in FIG. .
  • the presence or absence of a disk-shaped structure and the maximum length of one side of the cross-sectional shape of the disk-shaped structure are determined using a frozen replica transmission electron microscope (TEM, H-7650: manufactured by Hitachi, Ltd.). It can be confirmed or obtained from the photograph.
  • the maximum length of one side of the cross-sectional shape of the disk-shaped structure is the average value of 10 arbitrarily selected disk-shaped structures.
  • the disc-shaped structure is formed by the vesicles in the aqueous phase collapsing, and the monomolecular membrane of the bilayer membrane that constitutes the vesicle is partially replaced by the lipophilic part (hydrophobic part). After being adsorbed on the surface of the oil via the , are considered to be formed by lamination with hydrophilic portions interposed therebetween or oleophilic portions interposed therebetween. That is, the monomolecular film of the disk-like structure is typically composed of at least one kind of surfactant capable of forming vesicles.
  • the presence or absence of vesicles in cosmetics can be determined, for example, by a frozen replica method using a frozen replica transmission electron microscope (TEM, H-7650: manufactured by Hitachi, Ltd.), or by a small-angle X-ray scattering measurement device (SAXSess, Anton Paar) and Zetasizer Nano (Malvern Panalytical).
  • TEM frozen replica transmission electron microscope
  • SAXSess small-angle X-ray scattering measurement device
  • SAtasizer Nano Malvern Panalytical
  • the amount of the surfactant that constitutes the disk-shaped structure is 0.1% by mass or more and 0.1% by mass or more, based on the total amount of the cosmetic, from the viewpoint of the formability of the disk-shaped structure, emulsion stability, occlusion effect, etc. .3 mass % or more, or 0.5 mass % or more, and 10 mass % or less, 5.0 mass % or less, or 3.0 mass % or less.
  • the disc-shaped structure of the present disclosure can highly emulsify oil.
  • the emulsifying ability of the oil can be evaluated by the ratio of the mass of the oil to the mass of the surfactant forming the disk-shaped structure.
  • Such a mass ratio can be, for example, 20 or more, 30 or more, 40 or more, or 50 or more, and can be 90 or less, 85 or less, or 80 or less.
  • polyglycerin fatty acid esters can be preferably used from the viewpoint of formability of the disc-shaped structure, emulsion stability, and the like.
  • This polyglycerin fatty acid ester is a sustainable material, and as an incidental effect, it can provide a moist feeling when applied to the skin, and can improve the occlusion effect.
  • Polyglycerol fatty acid esters can be used alone or in combination of two or more.
  • Polyglycerin fatty acid esters can be prepared by esterifying fatty acids with polyglycerin as shown in the following reaction scheme:
  • the portion derived from fatty acids can be called a fatty acid portion
  • the portion derived from polyglycerin can be called a polyglycerin portion.
  • the fatty acid portion corresponds to the lipophilic portion
  • the polyglycerol portion corresponds to the hydrophilic portion.
  • the polyglycerol fatty acid ester preferably has a fatty acid moiety with 12 or more, 13 or more, or 14 or more carbon atoms from the viewpoint of disk-shaped structure formability, emulsion stability, occlusion effect, and the like. , 17 or less, 16 or less, or 15 or less.
  • Fatty acids that can be used when preparing polyglycerol fatty acid esters may be saturated fatty acids or unsaturated fatty acids, and may be linear fatty acids or branched fatty acids.
  • Such fatty acids can include, for example, lauric acid, myristic acid, and palmitic acid. Among them, myristic acid and lauric acid are preferred.
  • the polyglycerin portion of the polyglycerin fatty acid ester is preferably a trimer or higher or a tetramer or higher from the viewpoint of disk-shaped structure formability, emulsion stability, occlusion effect, etc.
  • it is preferably an octamer or less, a heptamer or less, or a hexamer or less, and more preferably a tetramer or more and an octamer or less.
  • the numerical value of n of the polyglycerol fatty acid ester in the above reaction formula matches, for example, the numerical value of 2 in the dimer.
  • the disc-shaped structure is preferably made of at least one polyglycerin fatty acid ester having an OH/C ratio of 0.30 to 0.80.
  • the OH/C ratio is preferably 0.30 or more, 0.35 or more, 0.40 or more, 0.45 or more, or 0.50 or more, and is 0.80 or less, 0.75 or less, It is preferably 0.70 or less, 0.65 or less, or 0.60 or less.
  • a polyglycerol fatty acid ester having such an OH/C ratio easily forms a disc-shaped structure, and can further improve the emulsion stability, occlusion effect, etc. of the oil-in-water emulsified cosmetic.
  • the "OH/C ratio" in the present disclosure means the ratio of the number of hydroxyl groups in the polyglycerin portion to the number of carbon atoms in the fatty acid portion, and is a parameter relating to the balance between hydrophilicity and lipophilicity.
  • polyglycerol fatty acid esters include polyglyceryl-6 myristate, polyglyceryl-4 laurate, polyglyceryl-5 laurate, polyglyceryl-6 laurate, and polyglyceryl-10 palmitate.
  • the oil-in-water emulsified cosmetic composition of the present disclosure can be appropriately blended with various components within a range that does not affect the effects of the present disclosure.
  • various components include additive components that can be usually blended in cosmetics, such as surfactants other than surfactants that constitute the disk-shaped structure, moisturizing agents, thickeners, water-soluble polymers, and highly oil-soluble ingredients.
  • Molecules film-forming agents, higher fatty acids, sequestering agents, lower alcohols, higher alcohols, polyhydric alcohols, various extracts, sugars, amino acids, organic amines, polymer emulsions, chelating agents, other than the above UV absorbers UV absorbers, pH adjusters, skin nutrients, vitamins, pharmaceuticals, quasi-drugs, water-soluble agents applicable to cosmetics, buffers, anti-fading agents, preservatives, dispersants, propellants, fillers , pigments, dyes, pigments, fragrances, and the like.
  • Optional components can be blended in the oil phase and/or the water phase, and can be used alone or in combination of two or more.
  • the disc-shaped structure in the oil-in-water emulsified cosmetic of the present disclosure functions as an emulsifier. Therefore, a surfactant other than the surfactant that constitutes the disc-shaped structure may be blended in the cosmetic, but from the viewpoint of the formability of the disc-shaped structure, the emulsion stability, etc., such a surfactant
  • the amount of the agent is 5.0% by mass or less, 3.0% by mass or less, 1.0% by mass or less, 0.5% by mass or less, or 0.1% by mass or less with respect to the total amount of the cosmetic. is preferred, and it is more preferred not to incorporate such a surfactant.
  • the oil-in-water emulsified cosmetic composition of the present disclosure has a viscosity of 25 Pa s or less and 23 Pa s or less immediately after preparation of the cosmetic composition as measured using the conditions and apparatus described in the examples below. ⁇ s or less, 20 Pa ⁇ s or less, or 19 Pa ⁇ s or less, or 1.0 Pa ⁇ s or more, 1.5 Pa ⁇ s or more, or 2.0 Pa ⁇ s or more.
  • Such a viscosity of the cosmetic immediately after preparation can be referred to as "initial viscosity”.
  • the oil-in-water emulsified cosmetic of the present disclosure has a pH of 7.0 or less, 6.8 or less, or 6.0 or less, as measured using the conditions and apparatus described in the examples below. 5 or less.
  • the lower limit of the pH of the cosmetic is not particularly limited, it is preferably 5.5 or higher or 6.0 or higher, for example, from the viewpoint of irritation to the skin.
  • the oil-in-water emulsified cosmetic of the present disclosure is not limited to the following method, but can be prepared as follows. Various materials described above can be used in the preparation of cosmetics.
  • a vesicle solution is formed by mixing a vesicle-forming surfactant such as a polyglycerol fatty acid ester with water optionally containing a water-soluble drug, an aqueous component, and the like. Then, an oil component containing an oil-soluble drug, an oily component, etc. is optionally added to the vesicle solution, and the mixture is stirred and mixed to obtain the oil-in-water emulsified cosmetic composition of the present disclosure.
  • a vesicle-forming surfactant such as a polyglycerol fatty acid ester
  • water optionally containing a water-soluble drug, an aqueous component, and the like.
  • an oil component containing an oil-soluble drug, an oily component, etc. is optionally added to the vesicle solution, and the mixture is stirred and mixed to obtain the oil-in-water emulsified cosmetic composition of the present disclosure.
  • the dosage form of the oil-in-water emulsified cosmetic of the present disclosure is not particularly limited, and examples thereof include liquid, milky lotion, cream, gel, spray, and mousse.
  • “spray” can include mist type spray, aerosol type spray, and the like.
  • oil-in-water emulsified cosmetics can be used, for example, as a cosmetic that is spread and applied to the skin, hair, or the like.
  • the product form of the cosmetics of the present disclosure is not particularly limited, but for example, facial cosmetics such as lotions, beauty essences, milky lotions, and packs; makeup cosmetics such as foundations, lipsticks, and eye shadows; body cosmetics; hair cosmetics such as hair liquids, hair tonics, hair conditioners, shampoos, rinses and hair restorers; and ointments.
  • the oil-in-water emulsified cosmetic of the present disclosure will be described in more detail below with reference to examples, but the cosmetic of the present disclosure is not limited to these.
  • the compounding amount is indicated by mass %.
  • ⁇ Evaluation of emulsion stability The size of the oil droplets within 1 hour after preparation of the cosmetic preparation and the size of the oil droplets after storage at 50°C for 4 weeks were observed with an optical microscope, and the emulsification stability was evaluated according to the following criteria.
  • a and B ratings can be considered pass and C rating fail: A: Almost no change in oil droplet size.
  • C The oil droplet size was obviously increased, or the cosmetic was separated.
  • the particle size of the emulsified particles (oil droplets) in the cosmetic is measured by direct visual observation with an optical microscope (BX60, manufactured by OLYMPUS), arbitrarily selecting 10 emulsified particles, and measuring the projected area circle of the emulsified particles. The average equivalent diameter is shown in the table.
  • Test Example 1 Emulsification stability of cosmetic along with formation of disc-shaped structure>>
  • Test Example 1 the emulsification stability of cosmetics accompanying the formation of disc-shaped structures was examined.
  • Table 1 shows the results.
  • the emulsification stability of the cosmetics of Comparative Examples 1 and 2 was poor, and thus the particle size, viscosity, and pH of the emulsified particles were not evaluated.
  • Example 1 No. 1 to No. 5, No. 12 and no.
  • the 13 materials were uniformly mixed to obtain an aqueous phase part containing vesicles.
  • Example 2-8 and Comparative Examples 1-2 Oil-in-water emulsified cosmetics of Examples 2-8 and Comparative Examples 1-2 were obtained in the same manner as in Example 1, except that the formulations shown in Table 1 were changed.
  • the surfactant is a polyglycerin fatty acid ester
  • a disc-shaped structure is easily obtained when the OH/C ratio is about 0.30 to 0.80.
  • Test Example 2 Emulsification performance of disc-shaped structure for various oils>>
  • Test Example 2 the emulsification performance of the disc-shaped structure for various oil components was examined. The results are shown in Tables 2-3. Tables 2 and 3 also show the results of Examples 3 and 4, respectively.
  • Example 9 to 21 Using the formulations shown in Tables 2 and 3, in the same manner as in Example 1, oil-in-water emulsified cosmetics of Examples 9 to 21 were obtained.
  • Test Example 3 Various performances such as penetration of cosmetics accompanying the formation of the disc-shaped structure>>
  • Test Example 3 in addition to the emulsification stability of the cosmetic along with the formation of the disc-shaped structure, penetration feeling, moist feeling, usability (stickiness) and film feeling were examined.
  • Table 4 shows the results.

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  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un produit cosmétique émulsifié de type huile dans l'eau qui est préparé à l'aide d'un nouvel émulsifiant et qui présente une excellente stabilité d'émulsification.　Un produit cosmétique émulsifié de type huile dans l'eau selon la présente divulgation contient : un milieu de dispersion contenant de l'eau ; et des gouttelettes d'huile dispersées dans le milieu de dispersion. Les gouttelettes d'huile comprennent chacune une teneur en huile et une structure de type disque. Les structures de type disque sont formées par stratification de films monomoléculaires ayant chacun une partie hydrophile et une partie lipophile, et sont disposées au niveau des interfaces des gouttelettes d'huile par rapport à la phase aqueuse.
PCT/JP2022/013232 2021-05-06 2022-03-22 Produit cosmétique émulsifié de type huile dans l'eau WO2022234737A1 (fr)

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CN202280027624.5A CN117120019A (zh) 2021-05-06 2022-03-22 水包油型乳化化妆料

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011241175A (ja) * 2010-05-18 2011-12-01 Kao Corp 油／ベシクル／水型乳化組成物及びそれを含有する化粧料
JP2017109975A (ja) * 2015-12-18 2017-06-22 ポーラ化成工業株式会社 水中油型乳化組成物
JP2020158539A (ja) * 2020-06-30 2020-10-01 ポーラ化成工業株式会社 水中油型乳化組成物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011241175A (ja) * 2010-05-18 2011-12-01 Kao Corp 油／ベシクル／水型乳化組成物及びそれを含有する化粧料
JP2017109975A (ja) * 2015-12-18 2017-06-22 ポーラ化成工業株式会社 水中油型乳化組成物
JP2020158539A (ja) * 2020-06-30 2020-10-01 ポーラ化成工業株式会社 水中油型乳化組成物

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JPWO2022234737A1 (fr) 2022-11-10

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