WO2022188721A1 - 抗pvrig蛋白抗体或抗体片段及其用途 - Google Patents
抗pvrig蛋白抗体或抗体片段及其用途 Download PDFInfo
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Abstract
Description
Claims (13)
- 一种抗体或抗体片段,其特征在于,所述抗体或抗体片段包括重链互补决定区HCDR1、HCDR2和HCDR3,以及轻链互补决定区LCDR1、LCDR2和LCDR3;其中HCDR1选自GYTFSSFS、GYTFSTFA或GYSFTAYT所示序列,HCDR2选自ILPGSNST、ILPGINNT、ILPGGNNT或者INPYNGGT所示序列,HCDR3选自SSYWFAY、STYWFAY或AREGNYYGSRGDFDY所示序列;其中,LCDR1选自QSLLNSGNQKNY或QTIVTN所示序列,LCDR2选自GAS或YAS所示序列;LCDR3选自QNAHSYPPT、QNAHSYPPA或QQSHSWPFT所示序列。
- 一种抗体或抗体片段,其特征在于,所述抗体或抗体片段分别选自下列中的一种:(1)所述抗体或抗体片段包括重链互补决定区和轻链互补决定区,所述重链互补决定区包括GYTFSSFS、ILPGSNST和SSYWFAY;所述轻链互补决定区包括QSLLNSGNQKNY、GAS和QNAHSYPPT;(2)所述抗体或抗体片段包括重链互补决定区和轻链互补决定区,所述重链互补决定区包括GYTFSTFA、ILPGINNT和STYWFAY;所述轻链互补决定区包括QSLLNSGNQKNY、GAS和QNAHSYPPT;(3)所述抗体或抗体片段包括重链互补决定区和轻链互补决定区,所述重链互补决定区包括GYTFSTFA、ILPGGNNT和STYWFAY;所述轻链互补决定区包括QSLLNSGNQKNY、GAS和QNAHSYPPA;(4)所述抗体或抗体片段包括重链互补决定区和轻链互补决定区,所述重链互补决定区包括GYSFTAYT、INPYNGGT和AREGNYYGSRGDFDY;所述轻链互补决定区包括QTIVTN、YAS和QQSHSWPFT。
- 一种抗体或抗体片段,其特征在于,所述抗体或抗体片段选自下列至少之一:(1)所述抗体或抗体片段包括重链可变区和轻链可变区,所述重链可变区为SEQ ID NO:1所示序列或者与SEQ ID NO:1所示序列相比具有至少一个氨基酸取代的序列,所述轻链可变区为SEQ ID NO:2所示序列或者与SEQ ID NO:2所示序列相比具有至少一个氨基酸取代的序列;(2)所述抗体或抗体片段包括重链可变区和轻链可变区,所述重链可变区选自SEQ ID NO:3、SEQ ID NO:6、SEQ ID NO:9、SEQ ID NO:12、SEQ ID NO:15、SEQ ID NO:18、SEQ ID NO:21、SEQ ID NO:24、SEQ ID NO:27、SEQ ID NO:30、SEQ ID NO:33所示序列或者与SEQ ID NO:3、SEQ ID NO:6、SEQ ID NO:9、SEQ ID NO:12、SEQ ID NO:15、SEQ ID NO:18、SEQ ID NO:21、SEQ ID NO:24、SEQ ID NO:27、SEQ ID NO:30、SEQ ID NO:33所示序列相比具有至少一个氨基酸取代的序列,所述轻链可变区为SEQ ID NO:36所示序列或者与SEQ ID NO:36所示序列相比具有至少一个氨基酸取代的序列;(3)所述抗体或抗体片段包括重链可变区和轻链可变区,所述重链可变区为SEQ ID NO:39所示序列或者与SEQ ID NO:39所示序列相比具有至少一个氨基酸取代的序列,所述轻链可变区为SEQ ID NO:40所示序列或者与SEQ ID NO:40所示序列相比具有至少一个氨基酸取代的序列;(4)所述抗体或抗体片段包括重链可变区和轻链可变区,所述重链可变区为SEQ ID NO:41所示序列或者与SEQ ID NO:41所示序列具有至少一个氨基酸取代的序列,所述轻链可变区为SEQ ID NO:42所示序列或者与SEQ ID NO:42所示序列相比具有至少一个氨基酸取代的序列;(5)所述抗体或抗体片段包括重链可变区和轻链可变区,所述重链可变区为SEQ ID NO:43所示序列或者与SEQ ID NO:43所示序列具有至少一个氨基酸取代的序列,所述轻链可变区为SEQ ID NO:44所示序列或者与SEQ ID NO:44所示序列相比具有至少一个氨基酸取代的序列。
- 根据权利要求3所述的抗体或抗体片段,其特征在于,包括重链和轻链,所述重链氨基酸序列为SEQ ID NO:4、SEQ ID NO:10、SEQ ID NO:13、SEQ ID NO:16、SEQ ID NO:19、SEQ ID NO:22、SEQ ID NO:25、SEQ ID NO:28、SEQ ID NO:31、SEQ ID NO:34所示序列,或者与SEQ ID NO:4、SEQ ID NO:10、SEQ ID NO:13、SEQ ID NO:16、SEQ ID NO:19、SEQ ID NO:22、SEQ ID NO:25、SEQ ID NO:28、SEQ ID NO:31、SEQ ID NO:34所示序列相比具有至少一个氨基酸取代的序列;所述轻链氨基酸序列为SEQ ID NO:37所示序列或者与SEQ ID NO:37所示序列相比至少具有一个氨基酸取代的序列。
- 一种可分离的核酸,其特征在于,所述核酸编码权利要求1~4中任一项所述的抗体或抗体片段。
- 一种表达载体,其特征在于,所述表达载体含有权利要求5所述的核酸。
- 一种宿主细胞,其特征在于,所述宿主细胞表达权利要求1~4中任一项所述的抗体或抗体片段。
- 根据权利要求7所述的宿主细胞,其特征在于,所述宿主细胞中含有权利要求6所述的表达载体。
- 一种药物组合物,其特征在于,所述药物组合物包括权利要求1~4中任一项所述的抗体或抗体片段和药学上可接受的载体。
- 权利要求1~4中任一项所述的抗体或抗体片段或者权利要求9所述的药物组合物在制备治疗癌症的药物中的用途。
- 一种药物联合,其特征在于,包括:(1)权利要求1~4中任一项所述的抗体或抗体片段,或者权利要求9所述的药物组合物;和(2)不同与(1)的用于癌症治疗的抗体。
- 一种在体外抑制样本中PVRIG蛋白活性的方法,其特征在于,包括将所述样本和权利要求1~4中任一项所述的抗体或抗体片段,或者权利要求9所述的药物组合物接触。
- 一种预防或者治疗癌症的方法,其特征在于,包括给予受试者有效量的权利要求1~4中任一项所述的抗体或抗体片段或者权利要求9所述的药物组合物。
Priority Applications (9)
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JP2023514157A JP2023542283A (ja) | 2021-03-08 | 2022-03-07 | 抗pvrigタンパク質抗体又は抗体断片及びその使用 |
IL299931A IL299931A (en) | 2021-03-08 | 2022-03-07 | Antibody or antibody fragment against PVRIG protein and its uses |
AU2022235121A AU2022235121A1 (en) | 2021-03-08 | 2022-03-07 | Anti-PVRIG protein antibody or antibody fragment and use thereof |
KR1020237006811A KR20230041810A (ko) | 2021-03-08 | 2022-03-07 | 항-pvrig 단백질 항체 또는 항체 단편 및 이의 용도 |
CA3189496A CA3189496C (en) | 2021-03-08 | 2022-03-07 | Anti-pvrig protein antibody or antibody fragment and use thereof |
EP22766246.7A EP4190815A1 (en) | 2021-03-08 | 2022-03-07 | Anti-pvrig protein antibody or antibody fragment, and use thereof |
MX2023000929A MX2023000929A (es) | 2021-03-08 | 2022-03-07 | Anticuerpo de proteina anti-pvrig o fragmento de anticuerpo y uso del mismo. |
ZA2023/00451A ZA202300451B (en) | 2021-03-08 | 2023-01-10 | Anti-pvrig protein antibody or antibody fragment and use thereof |
US18/160,886 US20230227572A1 (en) | 2021-03-08 | 2023-01-27 | Anti-pvrig protein antibody or antibody fragment and use thereof |
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CN202110250342.9 | 2021-03-08 |
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CA (1) | CA3189496C (zh) |
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MX (1) | MX2023000929A (zh) |
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Citations (5)
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US20170088607A1 (en) * | 2015-02-19 | 2017-03-30 | Compugen Ltd. | Pvrig polypeptides and methods of treatment |
CN107580500A (zh) * | 2015-02-19 | 2018-01-12 | 康姆普根有限公司 | 抗pvrig抗体和使用方法 |
WO2018017864A2 (en) * | 2016-07-20 | 2018-01-25 | Oncomed Pharmaceuticals, Inc. | Pvrig-binding agents and uses thereof |
CN110088132A (zh) * | 2016-08-17 | 2019-08-02 | 康姆普根有限公司 | 抗tigit抗体,抗pvrig抗体及其组合 |
CN112433055A (zh) * | 2020-11-04 | 2021-03-02 | 上海药明生物技术有限公司 | 一种基于报告基因方法检测pvrig抗体的生物学活性的方法 |
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- 2022-03-07 WO PCT/CN2022/079449 patent/WO2022188721A1/zh unknown
- 2022-03-07 IL IL299931A patent/IL299931A/en unknown
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ZA202300451B (en) | 2023-03-29 |
CA3189496A1 (en) | 2022-09-15 |
JP2023542283A (ja) | 2023-10-06 |
US20230227572A1 (en) | 2023-07-20 |
EP4190815A1 (en) | 2023-06-07 |
CN115925917A (zh) | 2023-04-07 |
IL299931A (en) | 2023-03-01 |
AU2022235121A1 (en) | 2023-03-16 |
MX2023000929A (es) | 2023-03-03 |
CA3189496C (en) | 2024-04-02 |
KR20230041810A (ko) | 2023-03-24 |
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