WO2022178693A1 - 可见光促进的 n-(2- 溴苯基 ) 硫代酰胺制备苯并噻唑类化合物的方法 - Google Patents

可见光促进的 n-(2- 溴苯基 ) 硫代酰胺制备苯并噻唑类化合物的方法 Download PDF

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WO2022178693A1
WO2022178693A1 PCT/CN2021/077531 CN2021077531W WO2022178693A1 WO 2022178693 A1 WO2022178693 A1 WO 2022178693A1 CN 2021077531 W CN2021077531 W CN 2021077531W WO 2022178693 A1 WO2022178693 A1 WO 2022178693A1
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reaction
bromophenyl
nmr
visible light
mhz
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PCT/CN2021/077531
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French (fr)
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李红喜
王昊
李海燕
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苏州大学
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Definitions

  • the invention belongs to the technical field of organic chemical synthesis methodology, in particular to a method for preparing benzothiazole compounds from N-(2-bromophenyl) thioamide promoted by visible light.
  • 2-Substituted benzothiazoles are building blocks widely found in pharmaceuticals, natural products, pesticides and functional materials. Therefore, their synthesis has received extensive attention from organic chemists.
  • the early synthesis of such compounds mainly includes: (1) oxidative condensation of 2-aminothiophenol and aryl aldehyde; (2) thiobenzamide Intramolecular carbon-hydrogen bond activation or carbon-halogen bond cross-coupling; (3) reaction of benzothiazole with aryl halide, (4) oxidative coupling of thiophenol and aryl nitrile, etc. These reactions are generally carried out at higher temperatures under the catalysis of palladium or other transition metals or their complexes.
  • the above reactions can also be carried out under visible or ultraviolet light irradiation in transition metal complexes such as [Ru(bpy) 3 ] 2+ , [Ir(ppy) 3 ] or organic photosensitive materials. catalyzed by the catalyst. But these reactions often add additional equipment, reagents, or separation costs, and may introduce toxic heavy metals or organic pollutants.
  • the present invention discloses a brand-new visible light-promoted method for preparing benzothiazole compounds from N-(2-bromophenyl)thioamide. That is, under visible light irradiation, using N-(2-bromophenyl) thioamide derivatives such as N-(2-bromophenyl) thioamide derivatives as raw materials, and using sodium phosphate as base, a series of 2 -Substituted benzothiazoles.
  • the reaction described in the present invention has a wide range of substrate application, and the desired benzothiazole compounds can be obtained in high yield.
  • the whole reaction process of the invention is green, efficient and easy to operate, and is a good method for synthesizing benzothiazole compounds.
  • the present invention adopts the following technical scheme: a method for preparing benzothiazole compounds from N-(2-bromophenyl) thioamide promoted by visible light, comprising the following steps, under visible light irradiation, in the presence of a base, to N-(2-bromophenyl) thioamide is used as raw material to prepare benzothiazole compounds.
  • the reaction is carried out at room temperature for 2 to 24 hours; the reaction is carried out in a solvent under the protection of an inert gas.
  • the molar ratio of N-(2-bromophenyl)thioamide and base is 1:(0.2-0.8), preferably 1:0.2-0.5, and most preferably 1:0.5.
  • N-(2-bromophenyl) thioamides and benzothiazole compounds have the following general structural formulas respectively: .
  • Ar 1 is a phenyl group or a substituted phenyl group
  • Ar 2 is a non-alkyl substituent group, such as a phenyl group, a substituted phenyl group or a heterocyclic group.
  • N-(2-bromophenyl) thioamide has the general structural formula shown in any one of formula (A) ⁇ formula (L) and formula (P): .
  • R 1 is selected from hydrogen, fluorine or methyl
  • R 2 is selected from fluorine, chlorine, bromine or methyl
  • R 3 is selected from fluorine, bromine or methyl
  • R 4 is selected from fluorine, chlorine, bromine, iodine, methyl
  • R 5 is selected from fluorine, bromine, iodine or methyl
  • R 6 is selected from fluorine, methyl or methoxy
  • R 7 is selected from hydrogen or fluorine.
  • A is N-(2-bromophenyl) thioamide
  • B is the obtained benzothiazole compound
  • the reaction of the present invention is carried out without photosensitizer or transition metal catalyst, which effectively solves the problem of the need for auxiliary (transition) catalyst in the prior art; the reaction can occur immediately after being irradiated by a simple 45W household compact fluorescent lamp, and unexpected results are obtained. technical effect.
  • the inert gas is selected from any one of nitrogen, helium, neon, and argon, preferably nitrogen;
  • the base is any one of inorganic bases, and the inorganic base is selected from sodium phosphate, sodium carbonate , any one of potassium carbonate, potassium hydroxide, sodium hydroxide, and sodium acetate, preferably sodium phosphate;
  • the solvent is dimethyl sulfoxide (DMSO), DMF, tetrahydrofuran (THF), methanol, ethanol, acetonitrile (MeCN), etc. .
  • the present invention that adopts the above-mentioned technical scheme has the following advantages: the present invention, without adding any photosensitizer or transition metal catalyst, uses sodium phosphate as an alkali, and under the irradiation of a 45W household compact fluorescent lamp, realizes A series of intramolecular cross-coupling reactions of N-(2-bromophenyl)thioamides.
  • the present invention can obtain benzothiazole-based compounds in high yield. The whole process is green, efficient and easy to operate, and it is a good method for synthesizing benzothiazoles.
  • the present invention can obtain benzothiazole compounds simply and efficiently without other reagents and reaction steps.
  • the stirring device is a magnetic stirring device; the reaction vessel is a sealed reaction tube.
  • the bromine site in the N-(2-bromophenyl)thioamide reacts with the sulfur site to prepare benzothiazole compounds, and the reaction is clear.
  • the present invention will be further described below with reference to specific embodiments. Unless otherwise specified, the reagents, materials, instruments, etc. used in the following examples are all commercially available.
  • the reaction of the present invention is carried out in the absence of photosensitizer or transition metal catalyst, and only N-(2-bromophenyl)thioamide, inorganic base and DMSO are used as raw materials; the reaction in the embodiment of the present invention is carried out at room temperature, using 45W household compact fluorescent lamps are visible light sources.
  • the specific experiments and testing methods of the present invention are conventional techniques.
  • Example 1 Visible light promotes the reaction of N-(2-bromophenyl)thiobenzamide.
  • the DMSO was replaced with DMF, and the rest remained unchanged, and the HPLC yield of the product was 77%.
  • the DMSO was replaced with a mixed solution of 1 mL of THF and 1 mL of acetonitrile, and the rest remained unchanged.
  • the HPLC yield of the product was 47%.
  • the DMSO was replaced with a mixed solution of 1 mL of THF and 1 mL of methanol, and the rest remained unchanged.
  • the HPLC yield of the product was 53%.
  • the 45W household compact fluorescent lamp irradiation was changed to green LED irradiation, and the rest remained unchanged, and the HPLC yield of the product was 4%.
  • Example 2 Visible light promotes the reaction of N-(2-bromo-5methylphenyl)thiobenzamide.
  • N-(2-Bromo- 5methylphenyl )thiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar Then, the reaction tube was replaced with N 3 times, and the reaction was stirred for 5 h under the irradiation of a 45W household compact fluorescent lamp. After the reaction, 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 97%.
  • Example 3 Visible light promotes the reaction of N-(2-bromo-5fluorophenyl)thiobenzamide.
  • N-(2-Bromo- 5fluorophenyl )thiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar , and then the reaction tube was replaced with N 3 times, and the reaction was stirred for 5 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 96%.
  • N-(2-Bromo- 4 -methylphenyl)thiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to the dry reaction with a magnetic stir bar tube, then the reaction tube was replaced with N 3 times, and the reaction was stirred for 10 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 98%.
  • Example 5 Visible light promoted N-(2-bromo-4-fluorophenyl)thiobenzamide reaction.
  • N-(2-Bromo- 4 -fluorophenyl)thiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar Then, the reaction tube was replaced with N 3 times, and the reaction was stirred for 10 h under the irradiation of a 45W household compact fluorescent lamp. After the reaction, 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 98%.
  • Example 6 Visible light promoted N-(2-bromo-4-chlorophenyl)thiobenzamide reaction.
  • N-(2-Bromo- 4 -chlorophenyl)thiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar Then, the reaction tube was replaced with N 3 times, and the reaction was stirred for 10 h under the irradiation of a 45W household compact fluorescent lamp. After the reaction, 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 96%.
  • Example 7 Visible light promoted N-(2,4-dibromophenyl)thiobenzamide reaction.
  • N-(2,4-Dibromophenyl)thiobenzamide (0.2 mmol), Na3PO4 ( 0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar , and then the reaction tube was replaced with N 3 times, and the reaction was stirred for 10 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 90%.
  • Example 8 Visible light promoted N-(2-bromo-3-methylphenyl)thiobenzamide reaction.
  • N-(2-Bromo- 3 -methylphenyl)thiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to the dry reaction with a magnetic stir bar tube, then the reaction tube was replaced with N 3 times, and the reaction was stirred for 5 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 95%.
  • Example 9 Visible light promoted N-(2-bromo-6-methylphenyl)thiobenzamide reaction.
  • N-(2-Bromo- 6 -methylphenyl)thiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to the dry reaction with a magnetic stir bar tube, then the reaction tube was replaced with N 3 times, and the reaction was stirred for 10 h under the irradiation of a 45W household compact fluorescent lamp. After the reaction, 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 95%.
  • Example 10 Visible light promoted N-(2-bromo-6-fluorophenyl)thiobenzamide reaction.
  • N-(2-Bromo- 6 -fluorophenyl)thiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar Then, the reaction tube was replaced with N 3 times, and the reaction was stirred for 3 h under the irradiation of a 45W household compact fluorescent lamp. After the reaction, 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 85%.
  • Example 11 Visible light promoted N-(2,6-dibromophenyl)thiobenzamide reaction.
  • N-(2,6-dibromophenyl)thiobenzamide (0.2 mmol), Na3PO4 ( 0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar , and then the reaction tube was replaced with N 3 times, and the reaction was stirred for 3 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 90%.
  • Example 12 Visible light promoted N-(2-bromophenyl)-4-methylthiobenzamide reaction.
  • N-(2-Bromophenyl)-4 - methylthiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to the dry reaction with a magnetic stir bar tube, and then the reaction tube was replaced with N 3 times, and the reaction was stirred for 3 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 98%.
  • Example 13 Visible light promoted N-(2-bromophenyl)-4-tert-butylthiobenzamide reaction.
  • Example 14 Visible light promotion of N-(2-bromophenyl)-4-methoxythiobenzamide reaction.
  • N-(2-Bromophenyl)-4 - methoxythiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry solution with a magnetic stir bar
  • the reaction tube was then replaced with N 3 times, and the reaction was stirred for 2 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 98%.
  • Example 15 Visible light promoted N-(2-bromophenyl)-4-fluorothiobenzamide reaction.
  • N-(2-Bromophenyl)-4 - fluorothiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar Then, the reaction tube was replaced with N 3 times, and the reaction was stirred for 5 h under the irradiation of a 45W household compact fluorescent lamp. After the reaction, 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 97%.
  • Example 16 Visible light promoted N-(2-bromophenyl)-4-chlorothiobenzamide reaction.
  • N-(2-Bromophenyl)-4 - chlorothiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar Then, the reaction tube was replaced with N 3 times, and the reaction was stirred for 5 h under the irradiation of a 45W household compact fluorescent lamp. After the reaction, 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 93%.
  • Example 17 Visible light promoted N-(2-bromophenyl)-4-bromothiobenzamide reaction.
  • N-(2-Bromophenyl)-4 - bromothiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar Then, the reaction tube was replaced with N 3 times, and the reaction was stirred for 5 h under the irradiation of a 45W household compact fluorescent lamp. After the reaction, 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 91%.
  • Example 18 Visible light promoted N-(2-bromophenyl)-4-iodothiobenzamide reaction.
  • N-(2-Bromophenyl)-4- iodothiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar Then, the reaction tube was replaced with N 3 times, and the reaction was stirred for 5 h under the irradiation of a 45W household compact fluorescent lamp. After the reaction, 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 86%.
  • Example 19 Visible light promoted N-(2-bromophenyl)-4-trifluoromethylthiobenzamide reaction.
  • N-(2-Bromophenyl)-4 - trifluoromethylthiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to dry with a magnetic stir bar Then, the reaction tube was replaced with N 3 times, and the reaction was stirred for 24 h under the irradiation of a 45W household compact fluorescent lamp. After the reaction, 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 94%.
  • Example 20 Visible light promoted N-(2-bromophenyl)-3-methylthiobenzamide reaction.
  • N-(2-Bromophenyl)-3 - methylthiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to the dry reaction with a magnetic stir bar tube, and then the reaction tube was replaced with N 3 times, and the reaction was stirred for 6 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 96%.
  • Example 21 Visible light promoted N-(2-bromophenyl)-3-methoxythiobenzamide reaction.
  • N-(2-Bromophenyl)-3 - methoxythiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry solution with a magnetic stir bar
  • the reaction tube was then replaced with N 3 times, and the reaction was stirred for 5 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 95%.
  • Example 22 Visible light promoted N-(2-bromophenyl)-3-fluorothiobenzamide reaction.
  • N-(2-Bromophenyl)-3 - fluorothiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar Then, the reaction tube was replaced with N 3 times, and the reaction was stirred for 10 h under the irradiation of a 45W household compact fluorescent lamp. After the reaction, 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 95%.
  • Example 23 Visible light promoted N-(2-bromophenyl)-3-bromothiobenzamide reaction.
  • Example 24 Visible light promoted N-(2-bromophenyl)-3-iodothiobenzamide reaction.
  • N-(2-Bromophenyl)-3- iodothiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar Then, the reaction tube was replaced with N 3 times, and the reaction was stirred for 5 h under the irradiation of a 45W household compact fluorescent lamp. After the reaction, 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 85%.
  • Example 25 Visible light promoted N-(2-bromophenyl)-2-methylthiobenzamide reaction.
  • N-(2-Bromophenyl)-2 - methylthiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to the dry reaction with a magnetic stir bar tube, then the reaction tube was replaced with N 3 times, and the reaction was stirred for 10 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 88%.
  • Example 26 Visible light promoted N-(2-bromophenyl)-2-methoxythiobenzamide reaction.
  • N-(2-Bromophenyl)-2 - methoxythiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry solution with a magnetic stir bar
  • the reaction tube was then replaced with N 3 times, and the reaction was stirred for 8 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 91%.
  • Example 27 Visible light promoted N-(2-bromophenyl)-2-fluorothiobenzamide reaction.
  • N-(2-Bromophenyl)-2 - fluorothiobenzamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar Then, the reaction tube was replaced with N 3 times, and the reaction was stirred for 24 h under the irradiation of a 45W household compact fluorescent lamp. After the reaction, 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 84%.
  • Example 28 Visible light promoted N-(2-bromophenyl)-3,4-dimethoxythiobenzamide reaction.
  • Example 29 Visible light promotion of N-(2-bromophenyl)thionaphthalene-2-carboxamide reaction.
  • N-(2-Bromophenyl)thionaphthalene- 2 -carboxamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar , and then the reaction tube was replaced with N 3 times, and the reaction was stirred for 10 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 86%.
  • Example 30 Visible light promoted N-(2-bromophenyl)thiopyridine-4-carboxamide reaction.
  • N-(2-Bromophenyl)thiopyridine- 4 -carboxamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar , and then the reaction tube was replaced with N 3 times, and the reaction was stirred for 20 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 84%.
  • Example 31 Visible light promotion of N-(2-bromophenyl)thiofuran-2-carboxamide reaction.
  • N-(2-Bromophenyl)thiofuran- 2 -carboxamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar , and then the reaction tube was replaced with N 3 times, and the reaction was stirred for 10 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 67%.
  • Example 32 Visible light promotion of N-(2-bromophenyl)thiothiophene-2-carboxamide reaction.
  • N-(2-Bromophenyl)thiothiophene- 2 -carboxamide (0.2 mmol), Na3PO4 (0.1 mmol), and DMSO ( 2 mL) were added to a dry reaction tube with a magnetic stir bar , and then the reaction tube was replaced with N 3 times, and the reaction was stirred for 10 h under the irradiation of a 45W household compact fluorescent lamp.
  • 4 mL of water was added, then extracted with 3 ⁇ 4 mL of ethyl acetate, the organic phases were combined, the organic phases were dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated by rotary evaporation, and separated by thin-layer chromatography on silica gel. , the target product was obtained with a yield of 92%.
  • Example 33 Visible light promoted N-(2-bromo-5-fluorophenyl)-3,4-dimethoxythiobenzamide reaction.
  • N-(2-Bromo- 5 -fluorophenyl)-3,4-dimethoxythiobenzamide 0.2 mmol
  • Na3PO4 0.1 mmol
  • DMSO 2 mL
  • Example 34 Visible light promoted N-(2-bromophenyl)thiobenzamide reaction.
  • N-(2-Bromophenyl)thiobenzamide (1.17 g, 4 mmol), Na3PO4 (0.5 equiv.), and DMSO ( 40 mL) were added to a dry reaction tube with a magnetic stir bar, Then the reaction tube was replaced with N 2 three times, and the reaction was stirred for 8 h under sunlight irradiation. After the reaction, 80 mL of water was added, and then extracted with 3 ⁇ 40 mL of ethyl acetate. The organic phases were combined, and the organic phases were dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated by rotary evaporation and separated by thin-layer chromatography on silica gel. , the target product was obtained in a yield of 73%, 0.85 g.
  • Example 35 Visible light-promoted N,N'-bis(2-bromophenyl)-thioterephthalamide reaction.

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Abstract

一种可见光促进的N-(2-溴苯基)硫代酰胺制备苯并噻唑类化合物的方法，在惰性气体保护下，按照N-(2-溴苯基)硫代酰胺∶无机碱＝1∶0.5的摩尔比，将上述反应物加入到配备搅拌装置的反应容器中，再加入二甲亚砜，可见光照射下，室温搅拌反应2-24小时，得到苯并噻唑类化合物。该方法在不添加任何光敏剂或者过渡金属催化剂的情况下，以磷酸钠作为碱，在45W家用紧凑型荧光灯照射下，实现了一系列N-(2-溴苯基)硫代酰胺的分子内交叉偶联反应，可以高收率获得苯并噻唑类化合物，整个过程绿色、高效且易于操作。

Description

可见光促进的N-(2-溴苯基)硫代酰胺制备苯并噻唑类化合物的方法 技术领域
本发明属于有机化学合成方法学技术领域，具体涉及可见光促进的N-(2-溴苯基)硫代酰胺制备苯并噻唑类化合物的方法。
 背景技术
2-取代的苯并噻唑类化合物是在药品，天然产物，农药和功能材料中广泛存在的结构单元。因此，它们的合成受到了有机化学家的广泛的关注，早期的合成这类化合物的主要有：（1）2-氨基苯硫酚与芳基醛的氧化缩合；（2）硫代苯甲酰胺的分子内碳-氢键活化或碳-卤键交叉偶联；（3）苯并噻唑与芳基卤化物的反应，（4）硫酚和芳基腈的氧化偶联等。这些反应一般在较高的温度下，在钯或等过渡金属或其配合物催化下进行。随着光氧化还原有机合成方法学的发展，上述反应也可以在可见或紫外光照射下，在[Ru(bpy) 3] 2+，[Ir(ppy) 3]等过渡金属配合物或有机光敏剂催化下发生。但是这些反应往往增加了额外的设备、试剂或分离成本，而且可能引入有毒的重金属或有机污染物。
技术问题
为了克服上述技术问题，本发明公开了一种全新的可见光促进的由N-(2-溴苯基)硫代酰胺制备苯并噻唑类化合物的方法。即在可见光照射下，以N-(2-溴苯基)硫代酰胺衍生物等N-(2-溴苯基)硫代酰胺为原料，以磷酸钠作为碱，顺利地合成了一系列2-取代的苯并噻唑类化合物。本发明所述反应具有广泛的底物适用范围，可以较高收率获得所需苯并噻唑类化合物。本发明的整个反应过程绿色、高效且易于操作，是一种合成苯并噻唑类化合物的好方法。
 技术解决方案
具体而言，本发明采用如下技术方案：可见光促进的N-(2-溴苯基)硫代酰胺制备苯并噻唑类化合物的方法，包括以下步骤，在可见光照射下，在碱存在下，以N-(2-溴苯基)硫代酰胺为原料反应制备苯并噻唑类化合物。
碱在以N-(2-溴苯基)硫代酰胺为原料反应制备苯并噻唑类化合物中的应用；优选的，反应在可见光下进行。
本发明中，所述反应为在室温下反应2～24小时；反应在惰性气体保护下，溶剂中进行。
本发明中，N-(2-溴苯基)硫代酰胺、碱的摩尔比为1:（0.2～0.8），优选为1:0.2～0.5，最优选1:0.5。
本发明中，所述N-(2-溴苯基)硫代酰胺、苯并噻唑类化合物分别具有如下结构通式：
Figure 396696dest_path_image001
。
其中Ar 1为苯基或者取代苯基，Ar 2为非烷基的取代基，比如苯基、取代苯基或者杂环基团。
具体的，所述N-(2-溴苯基)硫代酰胺具有如式（A）~式（L）、式（P）中的任意一种所示的结构通式：
Figure 500918dest_path_image002
。
其中：R 1选自氢、氟或者甲基；R 2选自氟、氯、溴或者甲基；R 3选自氟、溴或者甲基；R 4选自氟、氯、溴、碘、甲基、甲氧基、叔丁基或者三氟甲基；R 5选自氟、溴、碘或者甲基；R 6选自氟、甲基或者甲氧基；R 7选自氢或者氟。
本发明的技术方案可表示如下：
Figure 922672dest_path_image003
。
其中A为N-(2-溴苯基)硫代酰胺，B为得到的苯并噻唑类化合物。
本发明的反应在无光敏剂或者过渡金属催化剂条件下进行，有效解决了现有技术需要辅助（过渡）催化剂的问题；可以利用简单的45W家用紧凑型荧光灯照射即发生反应，取得了预料不到的技术效果。
本发明中，惰性气体选自氮气、氦气、氖气、氩气中的任意一种，优选氮气；所述碱为无机碱中的任意一种，所述无机碱选自磷酸钠、碳酸钠、碳酸钾、氢氧化钾、氢氧化钠、醋酸钠中的任意一种，优选磷酸钠；溶剂为二甲亚砜（DMSO）、DMF、四氢呋喃（THF）、甲醇、乙醇、乙腈（MeCN）等。
 有益效果
与现有技术相比，采用上述技术方案的本发明具有下列优点：本发明在不添加任何光敏剂或者过渡金属催化剂的情况下，以磷酸钠作为碱，在45W家用紧凑型荧光灯照射下，实现了一系列N-(2-溴苯基)硫代酰胺的分子内交叉偶联反应。此外，本发明可以高收率获得苯并噻唑类化合物。整个过程绿色、高效且易于操作，是一种合成苯并噻唑类化合物的好方法。
 本发明的实施方式
本发明公开的可见光促进的N-(2-溴苯基)硫代酰胺制备苯并噻唑类化合物的方法，具体为如下步骤：在惰性气体保护下，按照N-(2-溴苯基)硫代酰胺:无机碱=1:0.5的摩尔比，将上述反应物加入到配备搅拌装置的反应容器中，再加入二甲亚砜，于45W家用紧凑型荧光灯照射下，室温搅拌反应2-24小时，得到苯并噻唑类化合物。本发明无需其他试剂与反应步骤，可简单、高效的得到苯并噻唑类化合物。所述搅拌装置为磁力搅拌装置；所述反应容器为密封反应管。
本发明中，N-(2-溴苯基)硫代酰胺中的溴位点与硫位点反应制备苯并噻唑类化合物，反应明确。下面将结合具体的实施例对本发明做出进一步的描述。除非另有说明，下列实施例中所使用的试剂、材料、仪器等均可通过商业手段获得。本发明的反应在无光敏剂或者过渡金属催化剂存在下进行，仅采用N-(2-溴苯基)硫代酰胺、无机碱、DMSO为原料；本发明实施例的反应在室温下进行，使用45W家用紧凑型荧光灯为可见光源。本发明具体实验、测试方法为常规技术。
实施例1：可见光促进N-(2-溴苯基)硫代苯甲酰胺反应。
Figure 719727dest_path_image004
。
将N-(2-溴苯基)硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应5 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，分离收率98%，HPLC收率99%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.09–8.07 (m, J = 7.7 Hz, 3H), 7.90 (d, J = 7.9 Hz, 1H), 7.49 (m, 4H), 7.38 (t, J = 7.5 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 168.1, 154.2, 135.1, 133.6, 131.0, 129.0, 127.6, 126.3, 125.2, 123.2, 121.6。
在上述实验基础上，改变单一条件，得到如下实验：将Na 3PO 4更换为Na 2CO 3或者Et 3N，其余不变，产物HPLC收率分别为86%、87%。
将Na 3PO 4用量更换为0.2当量，其余不变，产物HPLC收率为91%。
将DMSO更换为DMF，其余不变，产物HPLC收率为77%。将DMSO更换为1 mL THF与1 mL乙腈的混合溶液，其余不变，产物HPLC收率为47%。将DMSO更换为1 mL THF与1 mL甲醇的混合溶液，其余不变，产物HPLC收率为53%。
不加入Na 3PO 4，即没有碱，其余不变，产物HPLC收率为76%。
空气中反应，其余不变，产物HPLC收率为61%。
避光下，其余不变，得不到产物；避光80℃反应，依然没有产物。
将45W家用紧凑型荧光灯照射更改为绿光LED照射，其余不变，产物HPLC收率4%。
将取代基溴更换为氯，其余不变，产物HPLC收率24%。
以下实施例涉及的产物收率都是分离收率。
实施例2：可见光促进N-(2-溴-5甲基苯基)硫代苯甲酰胺反应。
Figure 667dest_path_image005
。
将N-(2-溴-5甲基苯基)硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应5 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率97%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.06 (d, J = 3.7 Hz, 2H), 7.87 (s, 1H), 7.74 (d, J = 8.1 Hz, 1H), 7.52–7.40 (m, 3H), 7.19 (d, J = 8.1 Hz, 1H), 2.49 (s, 3H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 167.1, 153.5, 135.3, 132.7, 131.0, 129.8, 127.9, 126.4, 125.8, 122.2, 120.0, 20.4。
实施例3：可见光促进N-(2-溴-5氟苯基)硫代苯甲酰胺反应。
Figure 705317dest_path_image006
。
将N-(2-溴-5氟苯基)硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应5 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率96%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.15–8.00 (m, 2H), 7.82 (dd, J = 8.6, 5.2 Hz, 1H), 7.75 (dd, J = 9.5, 1.7 Hz, 1H), 7.56–7.44 (m, 3H), 7.16 (td, J = 8.7, 1.9 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 170.7, 162.1 (d, 1J C-F = 243.3 Hz), 155.2 (d, 3J C-F = 12.1 Hz), 133.6, 131.4, 130.6 (d, 4J C-F = 1.7 Hz), 129.2, 127.7, 122.4 (d, 3J C-F = 9.7 Hz), 114.0 (d, 2J C-F = 25.1 Hz), 109.5 (d, 2J C-F = 23.5 Hz)。 19F NMR (377 MHz, CDCl 3, ppm) δ -115.7。
实施例4：可见光促进N-(2-溴-4-甲基苯基)硫代苯甲酰胺反应。
Figure 450420dest_path_image007
。
将N-(2-溴-4-甲基苯基)硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应10 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率98%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.13–8.02 (m, 2H), 7.95 (d, J = 8.3 Hz, 1H), 7.70 (s, 1H), 7.52–7.45 (m, 3H), 7.30 (d, J = 8.2 Hz, 1H), 2.50 (s, 3H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 167.0, 152.3, 135.4, 135.2, 133.8, 130.8, 129.0, 128.0, 127.4, 122.7, 121.4, 21.6。
实施例5：可见光促进N-(2-溴-4-氟苯基)硫代苯甲酰胺反应。
Figure 90479dest_path_image008
。
将N-(2-溴-4-氟苯基)硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应10 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率98%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.03 (d, J = 3.1 Hz, 2H), 7.99 (dd, J = 9.0, 4.9 Hz, 1H), 7.59–7.51 (dd, 1H), 7.48 (d, J = 2.4 Hz, 3H), 7.21 (td, J = 8.9, 2.0 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ167.8, 160.5 (d, 1J C-F = 245.7 Hz), 150.8 (d, 4J C-F = 1.4 Hz, 1H)., 136.0 (d, 3J C-F = 11.2 Hz), 133.4, 131.0, 129.0, 127.4, 124.1 (d, 3J C-F = 9.4 Hz), 114.9 (d, 2J C-F = 24.7 Hz), 107.8 (d, 2J C-F = 26.8 Hz)。 19F NMR (377 MHz, CDCl 3, ppm) δ -115.8。
实施例6：可见光促进N-(2-溴-4-氯苯基)硫代苯甲酰胺反应。
Figure 921032dest_path_image009
。
将N-(2-溴-4-氯苯基)硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应10 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率96%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.04 (s, 2H), 7.95 (d, J = 8.6 Hz, 1H), 7.84 (s, 1H), 7.49 (s, 3H), 7.43 (d, J = 8.7 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 168.5, 152.7, 136.2, 133.2, 131.2, 131.1, 129.1, 127.5, 127.1, 123.9, 121.2。
实施例7：可见光促进N-(2,4-二溴苯基)硫代苯甲酰胺反应。
Figure 429374dest_path_image010
。
将N-(2,4-二溴苯基)硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应10 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率90%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.04 (s, 2H), 7.99 (s, 1H), 7.89 (d, J = 8.5 Hz, 1H), 7.57 (d, J = 8.4 Hz, 1H), 7.49 (s, 3H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 168.5, 153.0, 136.7, 133.2, 131.2, 129.8, 129.1, 127.5, 124.3, 124.1, 118.7。
实施例8：可见光促进N-(2-溴-3-甲基苯基)硫代苯甲酰胺反应。
Figure 28983dest_path_image011
。
将N-(2-溴-3-甲基苯基)硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应5 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率95%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.09 (d, J = 2.3 Hz, 2H), 7.91 (d, J = 8.0 Hz, 1H), 7.47 (s, 3H), 7.39 (t, J = 7.5 Hz, 1H), 7.16 (d, J = 7.0 Hz, 1H), 2.57 (s, 3H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 167.5, 154.0, 135.6, 133.7, 131.7, 130.8, 129.0, 127.5, 126.4, 125.4, 120.7, 21.4。
实施例9：可见光促进N-(2-溴-6-甲基苯基)硫代苯甲酰胺反应。
Figure 839944dest_path_image012
。
将N-(2-溴-6-甲基苯基)硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应10 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率95%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.11 (d, J = 3.9 Hz, 2H), 7.78–7.67 (m, 1H), 7.48 (d, J = 4.6 Hz, 3H), 7.27 (d, J = 5.2 Hz, 2H), 2.81 (s, 3H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 166.6, 153.6, 135.0, 134.0, 133.4, 130.7, 129.0, 127.5, 126.8, 125.1, 119.0, 18.4。
实施例10：可见光促进N-(2-溴-6-氟苯基)硫代苯甲酰胺反应。
Figure 157793dest_path_image013
。
将N-(2-溴-6-氟苯基)硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应3 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率85%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.01-8.21 (m, 2H), 7.64 (d, J = 7.9 Hz, 1H), 7.49 (s, 3H), 7.32 (dd, J = 12.1, 7.5 Hz, 1H), 7.18 (t, J = 9.2 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 168.6, 156.0 (d, 1J C-F = 256.4 Hz), 143.0 (d, 2J C-F = 13.5 Hz), 137.7 (d, 4J C-F = 3.6 Hz), 133.2, 131.3, 129.0, 127.8, 125.9 (d, 3J C-F = 7.2 Hz, 1H), 117.3 (d, 3J C-F = 4.3 Hz, 1H), 112.0 (d, 2J C-F = 18.0 Hz, 1H)。 19F NMR (377 MHz, CDCl 3, ppm) δ -121.9。
实施例11：可见光促进N-(2,6-二溴苯基)硫代苯甲酰胺反应。
Figure 204246dest_path_image014
。
将N-(2,6-二溴苯基)硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应3 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率90%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.11 (d, J = 4.3 Hz, 2H), 7.80 (d, J = 7.9 Hz, 1H), 7.66 (d, J = 7.6 Hz, 1H), 7.56-7.39 (m, 3H), 7.20 (t, J = 7.8 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 168.5, 152.3, 135.9, 133.2, 131.3, 129.7, 129.0, 127.7, 125.9, 120.8, 116.9。
实施例12：可见光促进N-(2-溴苯基)-4-甲基硫代苯甲酰胺反应。
Figure 923940dest_path_image015
。
将N-(2-溴苯基)-4-甲基硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应3 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率98%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.05 (d, J = 8.1 Hz, 1H), 7.97 (d, J = 7.9 Hz, 2H), 7.87 (d, J = 7.9 Hz, 1H), 7.47 (t, J = 7.6 Hz, 1H), 7.35 (t, J = 7.5 Hz, 1H), 7.28 (d, J = 7.8 Hz, 2H), 2.40 (s, 3H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 168.2, 154.2, 141.4, 135.0, 131.0, 129.7, 127.5, 126.2, 125.0, 123.1, 121.6, 21.5。
实施例13：可见光促进N-(2-溴苯基)-4-叔丁基硫代苯甲酰胺反应。
Figure 233699dest_path_image016
。
将N-(2-溴苯基)-4-叔丁基硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应3 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率98%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.07 (d, J = 8.2 Hz, 1H), 8.03 (d, J = 8.3 Hz, 2H), 7.90 (d, J = 7.9 Hz, 1H), 7.54–7.46 (m, 3H), 7.37 (t, J = 7.5 Hz, 1H), 1.37 (s, 9H)。 13C NMR (101 MHz, CDCl 3 ppm) δ 168.2, 154.6, 154.2, 135.0, 130.9, 127.4, 126.2, 126.0, 125.0, 123.1, 121.6, 35.0, 31.2。
实施例14：可见光促进N-(2-溴苯基)-4-甲氧基硫代苯甲酰胺反应。
Figure 976527dest_path_image017
。
将N-(2-溴苯基)-4-甲氧基硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应2 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率98%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.06–7.97 (m, J = 8.6 Hz, 3H), 7.85 (d, J = 7.9 Hz, 1H), 7.45 (t, J = 7.6 Hz, 1H), 7.33 (t, J = 7.5 Hz, 1H), 6.97 (d, J = 8.6 Hz, 2H), 3.85 (s, 3H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 167.8, 161.9, 154.2, 134.8, 129.1, 126.4, 126.2, 124.8, 122.8, 121.5, 114.3, 55.4。
实施例15：可见光促进N-(2-溴苯基)-4-氟硫代苯甲酰胺反应。
Figure 764354dest_path_image018
。
将N-(2-溴苯基)-4-氟硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应5 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率97%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.17–8.02 (m, 3H), 7.91 (d, J = 7.9 Hz, 1H), 7.50 (t, J = 7.6 Hz, 1H), 7.40 (t, J = 7.5 Hz, 1H), 7.19 (t, J = 8.3 Hz, 2H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 166.8, 164.5 (d, 1J C-F = 251.8 Hz), 154.1, 135.1, 130.0 (d, 4J C-F = 3.2 Hz), 129.5 (d, 3J C-F = 8.7 Hz), 126.4, 125.3, 123.2, 121.6, 116.2 (d, 2J C-F = 22.3 Hz)。 19F NMR (377 MHz, CDCl 3, ppm) δ -108.9。
实施例16：可见光促进N-(2-溴苯基)-4-氯硫代苯甲酰胺反应。
Figure 400872dest_path_image019
。
将N-(2-溴苯基)-4-氯硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应5 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率93%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.05 (d, J = 8.0 Hz, 1H), 7.99 (d, J = 7.8 Hz, 2H), 7.87 (d, J = 7.8 Hz, 1H), 7.48 (t, J = 7.6 Hz, 1H), 7.43 (d, J = 7.9 Hz, 2H), 7.37 (t, J = 7.4 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 166.6, 154.1, 137.0, 135.1, 132.1, 129.3, 128.7, 126.5, 125.4, 123.3, 121.7。
实施例17：可见光促进N-(2-溴苯基)-4-溴硫代苯甲酰胺反应。
Figure 615953dest_path_image020
。
将N-(2-溴苯基)-4-溴硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应5 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率91%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.05 (d, J = 8.0 Hz, 1H), 7.93 (d, J = 8.1 Hz, 2H), 7.88 (d, J = 7.8 Hz, 1H), 7.60 (d, J = 8.1 Hz, 2H), 7.49 (t, J = 7.4 Hz, 1H), 7.38 (t, J = 7.2 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 166.8, 154.2, 135.2, 132.7, 132.4, 129.1, 126.7, 125.6, 125.6, 123.5, 121.8。
实施例18：可见光促进N-(2-溴苯基)-4-碘硫代苯甲酰胺反应。
Figure 580498dest_path_image021
。
将N-(2-溴苯基)-4-碘硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应5 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率86%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.06 (d, J = 8.1 Hz, 1H), 7.89 (d, J = 7.8 Hz, 1H), 7.86–7.78 (m, 4H), 7.50 (t, J = 7.5 Hz, 1H), 7.40 (t, J = 7.4 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 166.8, 154.1, 138.2, 135.0, 133.1, 128.9, 126.5, 125.5, 123.3, 121.7, 97.5。
实施例19：可见光促进N-(2-溴苯基)-4-三氟甲基硫代苯甲酰胺反应。
Figure 172016dest_path_image022
。
将N-(2-溴苯基)-4-三氟甲基硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应24 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率94%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.19 (d, J = 7.9 Hz, 2H), 8.10 (d, J = 8.1 Hz, 1H), 7.92 (d, J = 7.9 Hz, 1H), 7.74 (d, J = 8.0 Hz, 2H), 7.52 (t, J = 7.6 Hz, 1H), 7.42 (t, J = 7.5 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 166.0, 154.1, 136.8, 135.2, 132.5 (q, 2J C-F = 32.8 Hz, 1H), 127.8, 126.7, 126.0 (q, 3J C-F = 3.8 Hz, 5H), 125.8, 123.8 (q, 1J C-F = 272.3 Hz, 1H) 123.6, 121.8。 19F NMR (377 MHz, CDCl 3, ppm) δ -62.8。
实施例20：可见光促进N-(2-溴苯基)-3-甲基硫代苯甲酰胺反应。
Figure 663040dest_path_image023
。
将N-(2-溴苯基)-3-甲基硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应6 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率96%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.07 (d, J = 8.1 Hz, 1H), 7.94 (s, 1H), 7.88 (dd, J = 13.2, 7.9 Hz, 2H), 7.49 (t, J = 7.6 Hz, 1H), 7.38 (t, J = 7.6 Hz, 2H), 7.30 (d, J = 7.4 Hz, 1H), 2.45 (s, 3H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 168.3, 154.1, 138.9, 135.0, 133.5, 131.8, 128.9, 128.0, 126.3, 125.1, 124.9, 123.2, 121.6, 21.4。
实施例21：可见光促进N-(2-溴苯基)-3-甲氧基硫代苯甲酰胺反应。
Figure 49022dest_path_image024
。
将N-(2-溴苯基)-3-甲氧基硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应5 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率95%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.07 (d, J = 8.1 Hz, 1H), 7.87 (d, J = 7.9 Hz, 1H), 7.67 (s, 1H), 7.62 (d, J = 7.5 Hz, 1H), 7.47 (t, J = 7.5 Hz, 1H), 7.36 (t, J = 7.3 Hz, 2H), 7.02 (d, J = 8.0 Hz, 1H), 3.89 (s, 3H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 167.9, 160.0, 154.0, 135.1, 134.9, 130.0, 126.3, 125.2, 123.2, 121.6, 120.2, 117.3, 112.0, 55.5。
实施例22：可见光促进N-(2-溴苯基)-3-氟硫代苯甲酰胺反应。
Figure 766443dest_path_image025
。
将N-(2-溴苯基)-3-氟硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应10 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率95%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.07 (d, J = 8.1 Hz, 1H), 7.88 (d, J = 7.9 Hz, 1H), 7.82 (d, J = 7.9 Hz, 2H), 7.49 (t, J = 7.6 Hz, 1H), 7.44–7.37 (m, 2H), 7.17 (t, J = 8.0 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 166.4 (d, 4J C-F = 3.3 Hz), 163.0 (d, 1J C-F = 247.3 Hz), 154.0, 135.7 (d, 3J C-F = 8.0 Hz), 135.1, 130.6 (d, 3J C-F = 8.1 Hz), 126.5, 125.5, 123.4, 123.3 (d, 4J C-F = 2.9 Hz), 121.7, 117.8 (d, 2J C-F = 21.3 Hz), 114.3 (d, 2J C-F = 23.6 Hz)。 19F NMR (377 MHz, CDCl 3, ppm) δ -112.0。
实施例23：可见光促进N-(2-溴苯基)-3-溴硫代苯甲酰胺反应。
Figure 896073dest_path_image026
。
将N-(2-溴苯基)-3-溴硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应5 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率85%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.27 (s, 1H), 8.08 (d, J = 8.1 Hz, 1H), 7.98 (d, J = 7.7 Hz, 1H), 7.90 (d, J = 7.9 Hz, 1H), 7.60 (d, J = 7.8 Hz, 1H), 7.51 (t, J = 7.6 Hz, 1H), 7.40 (t, J = 7.6 Hz, 1H), 7.35 (t, J = 7.9 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 166.1, 154.0, 135.5, 135.1, 133.8, 130.5, 130.3, 126.6, 126.2, 125.6, 123.5, 123.2, 121.7。
实施例24：可见光促进N-(2-溴苯基)-3-碘硫代苯甲酰胺反应。
Figure 241603dest_path_image027
。
将N-(2-溴苯基)-3-碘硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应5 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率85%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.45 (s, 1H), 8.06 (d, J = 8.1 Hz, 1H), 7.98 (d, J = 7.7 Hz, 1H), 7.88 (d, J = 7.9 Hz, 1H), 7.78 (d, J = 7.7 Hz, 1H), 7.49 (t, J = 7.5 Hz, 1H), 7.38 (t, J = 7.4 Hz, 1H), 7.18 (t, J = 7.7 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 165.9, 153.9, 139.7, 136.0, 135.4, 135.0, 130.5, 126.7, 126.5, 125.5, 123.4, 121.6, 94.7。
实施例25：可见光促进N-(2-溴苯基)-2-甲基硫代苯甲酰胺反应。
Figure 64066dest_path_image028
。
将N-(2-溴苯基)-2-甲基硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应10 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率88%。
1H NMR (400 MHz, CDCl 3 ppm) δ 8.10 (d, J = 8.1 Hz, 1H), 7.92 (d, J = 7.9 Hz, 1H), 7.75 (d, J = 7.5 Hz, 1H), 7.51 (t, J = 7.5 Hz, 1H), 7.44–7.27 (m, 4H), 2.66 (s, 3H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 168.0, 153.8, 137.2, 135.6, 133.1, 131.5, 130.5, 130.0, 126.1, 126.1, 125.1, 123.4, 121.4, 21.3。
实施例26：可见光促进N-(2-溴苯基)-2-甲氧基硫代苯甲酰胺反应。
Figure 3203dest_path_image029
。
将N-(2-溴苯基)-2-甲氧基硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应8 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率91%。
1H NMR (400 MHz, CDCl 3 ppm) δ 8.53 (d, J = 7.7 Hz, 1H), 8.09 (d, J = 8.1 Hz, 1H), 7.91 (d, J = 7.8 Hz, 1H), 7.53–7.41 (m, 2H), 7.35 (t, J = 7.4 Hz, 1H), 7.12 (t, J = 7.4 Hz, 1H), 7.04 (d, J = 8.2 Hz, 1H), 4.02 (s, 3H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 163.1, 157.2, 152.2, 136.1, 131.8, 129.5, 125.9, 124.6, 122.8, 122.3, 121.2, 121.2, 111.7, 55.7。
实施例27：可见光促进N-(2-溴苯基)-2-氟硫代苯甲酰胺反应。
Figure 936524dest_path_image030
。
将N-(2-溴苯基)-2-氟硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应24 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率84%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.42 (t, J = 7.4 Hz, 1H), 8.13 (d, J = 8.1 Hz, 1H), 7.95 (d, J = 7.9 Hz, 1H), 7.47 (ddd, J = 26.6, 15.2, 7.4 Hz, 3H), 7.32 (t, J = 7.5 Hz, 1H), 7.25 (dd, J = 10.3, 8.8 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ161.1 (d, 3J C-F = 5.7 Hz), 160.6 (d, 1J C-F = 253.3 Hz), 152.6, 135.8 (d, 3J C-F = 7.9 Hz), 132.2 (d, 2J C-F = 8.7 Hz), 129.8 (d, 4J C-F = 2.3 Hz), 126.3, 125.3, 124.7 (d, 3J C-F = 3.3 Hz), 123.3, 121.5, 121.4, 116.4 (d, 2J C-F = 21.9 Hz)。 19F NMR (377 MHz, CDCl 3, ppm) δ -111.9。
实施例28：可见光促进N-(2-溴苯基)-3,4-二甲氧基硫代苯甲酰胺反应。
Figure 136561dest_path_image031
。
将N-(2-溴苯基)- 3,4-二甲氧基硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应2 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率98%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.03 (d, J = 8.1 Hz, 1H), 7.86 (d, J = 7.9 Hz, 1H), 7.70 (s, 1H), 7.58 (d, J = 8.2 Hz, 1H), 7.47 (t, J = 7.6 Hz, 1H), 7.35 (t, J = 7.5 Hz, 1H), 6.92 (d, J = 8.3 Hz, 1H), 4.01 (s, 3H), 3.94 (s, 3H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 167.9, 154.1, 151.6, 149.3, 134.9, 126.6, 126.2, 124.9, 122.8, 121.5, 121.1, 111.0, 109.7, 56.1, 56.0。
实施例29：可见光促进N-(2-溴苯基)硫代萘-2-甲酰胺反应。
Figure 129925dest_path_image032
。
将N-(2-溴苯基)硫代萘-2-甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应10 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率86%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.54 (s, 1H), 8.19 (d, J = 8.5 Hz, 1H), 8.10 (d, J = 8.1 Hz, 1H), 7.97–7.81 (m, 4H), 7.56–7.46 (m, 3H), 7.37 (t, J = 7.5 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 168.1, 154.2, 135.1, 134.6, 133.2, 131.0, 128.8, 127.8, 127.6, 127.4, 126.8, 126.4, 125.2, 124.4, 123.2, 121.6。
实施例30：可见光促进N-(2-溴苯基)硫代吡啶-4-甲酰胺反应。
Figure 553428dest_path_image033
。
将N-(2-溴苯基)硫代吡啶-4-甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应20 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率84%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.78 (d, J = 5.3 Hz, 2H), 8.13 (d, J = 8.1 Hz, 1H), 7.95 (d, J = 4.1 Hz, 3H), 7.55 (t, J = 7.5 Hz, 1H), 7.46 (t, J = 7.5 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 165.1, 154.0, 150.8, 140.5, 135.2, 126.8, 126.2, 123.9, 121.9, 121.2。
实施例31：可见光促进N-(2-溴苯基)硫代呋喃-2-甲酰胺反应。
Figure 24861dest_path_image034
。
将N-(2-溴苯基)硫代呋喃-2-甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应10 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率67%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.05 (d, J = 8.1 Hz, 1H), 7.89 (d, J = 7.9 Hz, 1H), 7.61 (s, 1H), 7.49 (t, J = 7.6 Hz, 1H), 7.38 (t, J = 7.5 Hz, 1H), 7.19 (d, J = 2.8 Hz, 1H), 6.60 (s, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 157.6, 153.8, 148.8, 144.7, 134.3, 126.5, 125.2, 123.1, 121.6, 112.5, 111.4。
实施例32：可见光促进N-(2-溴苯基)硫代噻吩-2-甲酰胺反应。
Figure 344984dest_path_image035
。
将N-(2-溴苯基)硫代噻吩-2-甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应10 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率92%。
1H NMR (400 MHz, CDCl 3, ppm) δ 8.02 (d, J = 8.1 Hz, 1H), 7.83 (d, J = 7.9 Hz, 1H), 7.64 (d, J = 3.2 Hz, 1H), 7.51–7.42 (m, 2H), 7.35 (t, J = 7.5 Hz, 1H), 7.12 (t, J = 4.1 Hz, 1H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 161.4, 153.7, 137.4, 134.7, 129.3, 128.6, 128.0, 126.4, 125.2, 123.0, 121.4。
实施例33：可见光促进N-(2-溴-5-氟苯基)-3,4-二甲氧基硫代苯甲酰胺反应。
Figure 774828dest_path_image036
。
将N-(2-溴-5-氟苯基)-3,4-二甲氧基硫代苯甲酰胺（0.2 mmol），Na 3PO 4（0.1 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应24 h。反应结束后，加入4 mL水，然后用3×4 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率93%。
1H NMR (400 MHz, CDCl 3, ppm) δ 7.75 (dd, J = 8.6, 5.2 Hz, 1H), 7.72–7.63 (m, 2H), 7.58–7.50 (dd, J = 8.3 Hz, 1.1 Hz, 1H), 7.10 (td, J = 8.7, 1.9 Hz, 1H), 6.90 (d, J = 8.4 Hz, 1H), 4.01 (s, 3H), 3.94 (s, 3H)。 13C NMR (101 MHz, CDCl 3, ppm) δ 170.5, 162.0 (d, 1J C-F = 242.8 Hz), 155.2 (d, 3J C-F = 12.0 Hz), 151.9, 149.5, 130.4 (d, 4J C-F = 2.0 Hz), 126.6, 122.2 (d, 3J C-F = 9.9 Hz), 121.3, 113.5 (d, 2J C-F = 24.9 Hz), 111.1, 109.1 (d, 2J C-F = 23.6 Hz), 109.0, 56.2, 56.1。
19F NMR (377 MHz, CDCl3, ppm) δ -116.0。
实施例34：可见光促进N-(2-溴苯基)硫代苯甲酰胺反应。
Figure 485295dest_path_image037
。
将N-(2-溴苯基)硫代苯甲酰胺（1.17g， 4mmol），Na 3PO 4（0.5当量），以及DMSO（40 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在太阳光照射下，搅拌反应8 h。反应结束后，加入80 mL水，然后用3×40 mL乙酸乙酯萃取，合并有机相，有机相再用无水硫酸钠干燥，过滤，滤液旋转蒸发浓缩后，经硅胶色谱薄层层析分离，得到目标产物，收率73%，0.85g。
实施例35：可见光促进N,N’-二(2-溴苯基)-硫代对苯二甲酰胺反应。
Figure 698102dest_path_image038
。
将N,N’-二(2-溴苯基)-硫代对苯二甲酰胺（0.2 mmol），Na 3PO 4（0.2 mmol），以及DMSO（2 mL）加入带有磁力搅拌子的干燥的反应管中，接着该反应管用N 2置换3次，在45W家用紧凑型荧光灯照射下，搅拌反应10 h。反应结束后，过滤收集沉淀，并用DMF重结晶，再次过滤并用乙醇和四氢呋喃冲洗沉淀，干燥得到目标产物，收率82%。产物微溶于常见的已知溶剂， 13C NMR信号弱，故仅使用 1H NMR表征。
1H NMR (400 MHz, DMSO, ppm) δ 8.14 (s, 4H), 7.75 (d, J = 7.8 Hz, 2H), 7.58 (d, J = 7.8 Hz, 2H), 7.46 (t, J = 7.4 Hz, 2H), 7.26 (t, J = 7.4 Hz, 2H)。

Claims (10)

  1. 可见光促进的N-(2-溴苯基)硫代酰胺制备苯并噻唑类化合物的方法，其特征在于，包括以下步骤，在可见光照射下，在碱存在下，以N-(2-溴苯基)硫代酰胺为原料反应制备苯并噻唑类化合物；所述N-(2-溴苯基)硫代酰胺具有如下结构通式：
    Figure 958054dest_path_image001
    ；其中Ar 1为苯基或者取代苯基，Ar 2为非烷基的取代基。
  2. 根据权利要求1所述的方法，其特征在于，所述反应在惰性气体保护下、碱存在下、溶剂中进行。
  3. 根据权利要求1所述的方法，其特征在于，N-(2-溴苯基)硫代酰胺、碱的摩尔比为1:（0.2～0.8）。
  4. 根据权利要求1所述的方法，其特征在于，所述碱为无机碱。
  5. 根据权利要求1所述的方法，其特征在于，Ar 2为苯基、取代苯基或者杂环基团。
  6. 根据权利要求1所述的方法，其特征在于，所述反应为在室温下反应2～24小时。
  7. 碱在以N-(2-溴苯基)硫代酰胺为原料反应制备苯并噻唑类化合物中的应用；所述碱为无机碱。
  8. 根据权利要求7所述的应用，其特征在于，所述碱选自磷酸钠、碳酸钠、碳酸钾、氢氧化钾、氢氧化钠、醋酸钠中的任意一种。
  9. 根据权利要求7所述的应用，其特征在于：所述苯并噻唑类化合物具有如下结构通式：
    Figure 53049dest_path_image002
    ；其中Ar 1为苯基或者取代苯基，Ar 2为非烷基的取代基。
  10. 根据权利要求1所述的方法制备的苯并噻唑类化合物。
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CN103788013A (zh) * 2014-02-12 2014-05-14 温州大学 一种2-芳基苯并噻唑化合物的合成方法
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