WO2022143740A8 - A3腺苷受体激动剂及其制备方法和用途 - Google Patents

A3腺苷受体激动剂及其制备方法和用途 Download PDF

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Publication number
WO2022143740A8
WO2022143740A8 PCT/CN2021/142384 CN2021142384W WO2022143740A8 WO 2022143740 A8 WO2022143740 A8 WO 2022143740A8 CN 2021142384 W CN2021142384 W CN 2021142384W WO 2022143740 A8 WO2022143740 A8 WO 2022143740A8
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Prior art keywords
adenosine
activity
compounds
series
receptor agonists
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PCT/CN2021/142384
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English (en)
French (fr)
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WO2022143740A1 (zh
Inventor
胡崇波
叶进启
潘姝花
胡宁
潘婷婷
赵龙
陈正树
孙三兴
Original Assignee
浙江春禾医药科技有限公司
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Application filed by 浙江春禾医药科技有限公司 filed Critical 浙江春禾医药科技有限公司
Priority to AU2021413448A priority Critical patent/AU2021413448A1/en
Priority to US18/270,117 priority patent/US20240116975A1/en
Priority to CN202180088308.4A priority patent/CN116783196A/zh
Priority to JP2023540498A priority patent/JP2024502068A/ja
Priority to KR1020237023189A priority patent/KR20230125800A/ko
Priority to CA3203676A priority patent/CA3203676A1/en
Priority to EP21914472.2A priority patent/EP4273153A4/en
Publication of WO2022143740A1 publication Critical patent/WO2022143740A1/zh
Publication of WO2022143740A8 publication Critical patent/WO2022143740A8/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

提供了一种对A3腺苷受体活性既有调节或激动作用的化合物，该系列化合物的制备方法，该系列化合物的药物组合物，以及该系列化合物的医药用途。该系列化合物可以作为高效的A3腺苷受体激动剂，具有抗肿瘤、抗炎、止痛、神经保护、心肌防护、眼疾治疗和抗感染等多种药理活性。
PCT/CN2021/142384 2020-12-29 2021-12-29 A3腺苷受体激动剂及其制备方法和用途 WO2022143740A1 (zh)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2021413448A AU2021413448A1 (en) 2020-12-29 2021-12-29 Adenosine a3 receptor agonists, preparation methods and uses thereof
US18/270,117 US20240116975A1 (en) 2020-12-29 2021-12-29 Adenosine a3 receptor agonists, preparation methods and uses thereof
CN202180088308.4A CN116783196A (zh) 2020-12-29 2021-12-29 A3腺苷受体激动剂及其制备方法和用途
JP2023540498A JP2024502068A (ja) 2020-12-29 2021-12-29 Ａ３アデノシン受容体アゴニスト及びその調製方法と用途
KR1020237023189A KR20230125800A (ko) 2020-12-29 2021-12-29 A3 아데노신 수용체 작용제 및 이의 제조 방법과 용도
CA3203676A CA3203676A1 (en) 2020-12-29 2021-12-29 Adenosine a3 receptor agonists, preparation methods and uses thereof
EP21914472.2A EP4273153A4 (en) 2020-12-29 2021-12-29 ADENOSINE A3 RECEPTOR AGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202011601817 2020-12-29
CN202011601817.6 2020-12-29

Publications (2)

Publication Number Publication Date
WO2022143740A1 WO2022143740A1 (zh) 2022-07-07
WO2022143740A8 true WO2022143740A8 (zh) 2023-07-13

Family

ID=82260231

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2021/142384 WO2022143740A1 (zh) 2020-12-29 2021-12-29 A3腺苷受体激动剂及其制备方法和用途

Country Status (8)

Country Link
US (1) US20240116975A1 (zh)
EP (1) EP4273153A4 (zh)
JP (1) JP2024502068A (zh)
KR (1) KR20230125800A (zh)
CN (1) CN116783196A (zh)
AU (1) AU2021413448A1 (zh)
CA (1) CA3203676A1 (zh)
WO (1) WO2022143740A1 (zh)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773423A (en) * 1993-07-13 1998-06-30 The United States Of America As Represented By The Department Of Health And Human Services A3 adenosine receptor agonists
US20030078232A1 (en) * 2001-08-08 2003-04-24 Elfatih Elzein Adenosine receptor A3 agonists
US7262176B2 (en) * 2001-08-08 2007-08-28 Cv Therapeutics, Inc. Adenosine A3 receptor agonists
AU2002362443B2 (en) * 2001-10-01 2008-05-15 University Of Virginia Patent Foundation 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
WO2003061670A1 (en) * 2002-01-25 2003-07-31 Muscagen Limited Compounds useful as a3 adenosine receptor agonists
US7514417B2 (en) * 2005-05-19 2009-04-07 Cv Therapeutics, Inc. A1 adenosine receptor agonists
GB0607947D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic Compounds
WO2008156513A2 (en) * 2007-03-29 2008-12-24 University Of Connecticut Methods to protect skeletal muscle against injury
EP4306525A3 (en) * 2016-01-08 2024-03-20 Arcus Biosciences, Inc. Modulators of 5'-nucleotidase, ecto and the use thereof
JP2020515559A (ja) * 2017-03-31 2020-05-28 ぺロトン セラピューティクス，インク． Ｃｄ７３阻害剤とその使用
WO2020247546A1 (en) * 2019-06-03 2020-12-10 Biointervene, Inc. Adenosine analogs for the treatment of disease

Also Published As

Publication number Publication date
EP4273153A1 (en) 2023-11-08
KR20230125800A (ko) 2023-08-29
US20240116975A1 (en) 2024-04-11
JP2024502068A (ja) 2024-01-17
EP4273153A4 (en) 2024-05-08
AU2021413448A1 (en) 2023-07-20
CN116783196A (zh) 2023-09-19
CA3203676A1 (en) 2022-07-07
WO2022143740A1 (zh) 2022-07-07

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