WO2022143740A8 - A3腺苷受体激动剂及其制备方法和用途 - Google Patents

A3腺苷受体激动剂及其制备方法和用途 Download PDF

Info

Publication number
WO2022143740A8
WO2022143740A8 PCT/CN2021/142384 CN2021142384W WO2022143740A8 WO 2022143740 A8 WO2022143740 A8 WO 2022143740A8 CN 2021142384 W CN2021142384 W CN 2021142384W WO 2022143740 A8 WO2022143740 A8 WO 2022143740A8
Authority
WO
WIPO (PCT)
Prior art keywords
adenosine
activity
compounds
series
receptor agonists
Prior art date
Application number
PCT/CN2021/142384
Other languages
English (en)
French (fr)
Other versions
WO2022143740A1 (zh
Inventor
胡崇波
叶进启
潘姝花
胡宁
潘婷婷
赵龙
陈正树
孙三兴
Original Assignee
浙江春禾医药科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 浙江春禾医药科技有限公司 filed Critical 浙江春禾医药科技有限公司
Priority to KR1020237023189A priority Critical patent/KR20230125800A/ko
Priority to JP2023540498A priority patent/JP2024502068A/ja
Priority to CA3203676A priority patent/CA3203676A1/en
Priority to CN202180088308.4A priority patent/CN116783196A/zh
Priority to AU2021413448A priority patent/AU2021413448A1/en
Priority to EP21914472.2A priority patent/EP4273153A4/en
Priority to US18/270,117 priority patent/US20240116975A1/en
Publication of WO2022143740A1 publication Critical patent/WO2022143740A1/zh
Publication of WO2022143740A8 publication Critical patent/WO2022143740A8/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/167Purine radicals with ribosyl as the saccharide radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

提供了一种对A3腺苷受体活性既有调节或激动作用的化合物,该系列化合物的制备方法,该系列化合物的药物组合物,以及该系列化合物的医药用途。该系列化合物可以作为高效的A3腺苷受体激动剂,具有抗肿瘤、抗炎、止痛、神经保护、心肌防护、眼疾治疗和抗感染等多种药理活性。
PCT/CN2021/142384 2020-12-29 2021-12-29 A3腺苷受体激动剂及其制备方法和用途 WO2022143740A1 (zh)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1020237023189A KR20230125800A (ko) 2020-12-29 2021-12-29 A3 아데노신 수용체 작용제 및 이의 제조 방법과 용도
JP2023540498A JP2024502068A (ja) 2020-12-29 2021-12-29 A3アデノシン受容体アゴニスト及びその調製方法と用途
CA3203676A CA3203676A1 (en) 2020-12-29 2021-12-29 Adenosine a3 receptor agonists, preparation methods and uses thereof
CN202180088308.4A CN116783196A (zh) 2020-12-29 2021-12-29 A3腺苷受体激动剂及其制备方法和用途
AU2021413448A AU2021413448A1 (en) 2020-12-29 2021-12-29 Adenosine a3 receptor agonists, preparation methods and uses thereof
EP21914472.2A EP4273153A4 (en) 2020-12-29 2021-12-29 ADENOSINE A3 RECEPTOR AGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF
US18/270,117 US20240116975A1 (en) 2020-12-29 2021-12-29 Adenosine a3 receptor agonists, preparation methods and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202011601817.6 2020-12-29
CN202011601817 2020-12-29

Publications (2)

Publication Number Publication Date
WO2022143740A1 WO2022143740A1 (zh) 2022-07-07
WO2022143740A8 true WO2022143740A8 (zh) 2023-07-13

Family

ID=82260231

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2021/142384 WO2022143740A1 (zh) 2020-12-29 2021-12-29 A3腺苷受体激动剂及其制备方法和用途

Country Status (8)

Country Link
US (1) US20240116975A1 (zh)
EP (1) EP4273153A4 (zh)
JP (1) JP2024502068A (zh)
KR (1) KR20230125800A (zh)
CN (1) CN116783196A (zh)
AU (1) AU2021413448A1 (zh)
CA (1) CA3203676A1 (zh)
WO (1) WO2022143740A1 (zh)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0708781B1 (en) * 1993-07-13 2001-10-04 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services A 3 adenosine receptor agonists
US7214665B2 (en) * 2001-10-01 2007-05-08 University Of Virginia Patent Foundation 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
US20030078232A1 (en) * 2001-08-08 2003-04-24 Elfatih Elzein Adenosine receptor A3 agonists
US7262176B2 (en) * 2001-08-08 2007-08-28 Cv Therapeutics, Inc. Adenosine A3 receptor agonists
CA2474337A1 (en) * 2002-01-25 2003-07-31 Muscagen Limited Compounds useful as a3 adenosine receptor agonists
CA2609117A1 (en) * 2005-05-19 2006-11-23 Cv Therapeutics, Inc. A1 adenosine receptor agonists
GB0607947D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic Compounds
WO2008156513A2 (en) * 2007-03-29 2008-12-24 University Of Connecticut Methods to protect skeletal muscle against injury
PL3399984T3 (pl) * 2016-01-08 2024-02-19 Arcus Biosciences, Inc. Modulatory ekto-5’-nukleotydazy oraz ich zastosowanie
JP2020515559A (ja) * 2017-03-31 2020-05-28 ぺロトン セラピューティクス,インク. Cd73阻害剤とその使用
WO2020247546A1 (en) * 2019-06-03 2020-12-10 Biointervene, Inc. Adenosine analogs for the treatment of disease

Also Published As

Publication number Publication date
CN116783196A (zh) 2023-09-19
CA3203676A1 (en) 2022-07-07
EP4273153A4 (en) 2024-05-08
KR20230125800A (ko) 2023-08-29
AU2021413448A1 (en) 2023-07-20
WO2022143740A1 (zh) 2022-07-07
US20240116975A1 (en) 2024-04-11
EP4273153A1 (en) 2023-11-08
JP2024502068A (ja) 2024-01-17

Similar Documents

Publication Publication Date Title
MX2021000887A (es) Compuestos espiroheterociclicos y metodos de uso de los mismos para el tratamiento de cancer.
MX2022008066A (es) Compuestos triciclicos sustituidos.
CR20220281A (es) Derivados de pirazolilo útiles como agentes anti-cancerígenos
MX2019013954A (es) Inhibidores covalentes de kras.
PH12020551870A1 (en) Tetracyclic heteroaryl compounds
WO2020257549A3 (en) Compounds for treatment of pd-l1 diseases
MX2020000268A (es) Agonista de fxr.
MX2022006475A (es) Compuestos triciclicos sustituidos.
JOP20190229A1 (ar) مركبات تثبط بروتين mcl-1
WO2016164675A8 (en) Substituted quinazoline compounds and methods of use thereof
ZA202007681B (en) Pharmaceutical combination, composition and combination formulation comprising glucokinase activator and dpp-iv inhibitor, and preparation method and use thereof
AU2018251118A8 (en) Pharmaceutical composition containing MOR agonist and KOR agonist, and uses thereof
BRPI0720551A2 (pt) composto ou um sal farmaceuticamente aceitável do mesmo, e, uso do mesmo, método para o tratamento de câncer, processos para a preparação de uma composição farmacêutica e de um composto ou de um sal farmaceuticamente aceitável do mesmo
WO2019177375A8 (ko) 2, 4, 5-치환된 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물
AR122351A1 (es) Derivados de metilquinazolinona como inhibidores de braf
MX2020010942A (es) Inhibidores dobles de atm y adn-pk para uso en terapias antitumorales.
WO2021009676A8 (en) Imidazo[4,5-c]pyridine derivatives as toll-like receptor agonists
MX2021015543A (es) Derivado de pirimidina que inhibe el crecimiento de celulas cancerosas y uso medicinal del mismo.
MX2020010618A (es) Derivados de pirazolotriazolopiriminina como antagonista del receptor a2a.
MX2022013984A (es) Inhibidores de cinasa 7 relacionada con el gen nunca en mitosis a (nek7).
AU2019375825A8 (en) Macrocyclic tyrosine kinase inhibitor and uses thereof
MX2022000430A (es) Administracion de agonista de sting e inhibidores de puntos de control.
MX2021012105A (es) Compuestos de pirrol.
MX2021007247A (es) Derivados de rapamicina.
MX2021016149A (es) Inhibidores de la replicacion del virus de inmunodeficiencia humana.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21914472

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 3203676

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2023540498

Country of ref document: JP

Ref document number: 202180088308.4

Country of ref document: CN

ENP Entry into the national phase

Ref document number: 20237023189

Country of ref document: KR

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2021413448

Country of ref document: AU

Date of ref document: 20211229

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2021914472

Country of ref document: EP

Effective date: 20230731