WO2022142195A1 - 一种微针贴片及其制备方法 - Google Patents
一种微针贴片及其制备方法 Download PDFInfo
- Publication number
- WO2022142195A1 WO2022142195A1 PCT/CN2021/102217 CN2021102217W WO2022142195A1 WO 2022142195 A1 WO2022142195 A1 WO 2022142195A1 CN 2021102217 W CN2021102217 W CN 2021102217W WO 2022142195 A1 WO2022142195 A1 WO 2022142195A1
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- WO
- WIPO (PCT)
- Prior art keywords
- microneedle patch
- resveratrol
- composition
- needle body
- preparation
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical class C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims abstract description 39
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims abstract description 22
- 235000013793 astaxanthin Nutrition 0.000 claims abstract description 22
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims abstract description 22
- 229940022405 astaxanthin Drugs 0.000 claims abstract description 22
- 239000001168 astaxanthin Substances 0.000 claims abstract description 22
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- 239000000243 solution Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 11
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- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D44/00—Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
- A45D44/002—Masks for cosmetic treatment of the face
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Definitions
- the invention belongs to the technical field of medical devices, and in particular relates to a component for introducing a medium into the body through skin penetration and a preparation method thereof.
- Ultraviolet rays kill our skin cells and damage the cells' DNA so that skin cells cannot regenerate benignly. It is manifested as rough, thickened, dry skin on the exposed part of the skin, loose skin, deepening and thickening of wrinkles, local hyperpigmentation or telangiectasia, and even various benign or malignant tumors (such as solar keratosis, squamous cells) may appear. cancer, malignant melanoma, etc.).
- the stretched parts of the face, neck and upper limbs of the human body are the most prone to photoaging, and good photoprotection will reduce the aging by about 80%.
- Cosmetic facial beauty is a commonly used method.
- the skin care products listed on the market are mainly divided into water, milk, cream, cream and mask.
- the masks are mainly divided into two types: smear-type masks and patch-type masks.
- smear-type masks the texture is mainly paste or milky, which needs to be applied to the face, and the application steps are complicated. If you apply too much, too much emulsion can lead to clogged pores, the formation of fat granules, resulting in closed mouth, and even acne.
- patch type masks such as non-woven masks, the essence is covered on the non-woven fabric.
- Cosmetic surgery has certain technical difficulties and risks, and it is often carried out by injecting hyaluronic acid, botulinum toxin, snake toxin, facelift, radio frequency laser and other methods. In terms of specific implementation, it must be carried out in specialized institutions, and has a narrow scope of application, high risk, high price and long recovery period. Because photoaging is a long-term and uninterrupted external cause of damage to the skin, it is difficult to maintain the long-term effect of surgery.
- the invention provides a microneedle patch and a preparation method thereof, which are used to solve the problems of unstable active ingredients, limited skin absorption and unsatisfactory cosmetic effect in the existing anti-photoaging, repairing and anti-aging patches.
- the microneedle patch includes a base and a plurality of needle bodies arranged on the surface of the base, the needle bodies are soluble cones, and the needle bodies have A cosmetically effective composition comprising astaxanthin, hydrophilically modified resveratrol, collagen and hyaluronic acid.
- Astaxanthin and resveratrol are unstable and easy to inactivate, causing them to fail to exert their due effects when used in anti-photoaging skin care products.
- the technical solution provided by the present invention combines the hydrophilically modified resveratrol with After astaxanthin, collagen and hyaluronic acid are mixed to make microneedles, the active ingredients are effectively sealed and isolated from the outside world, thus overcoming the above problems.
- the combined use of astaxanthin, resveratrol, collagen and hyaluronic acid can play a synergistic effect on the skin's resistance to photoaging, repair and anti-aging.
- the needle body dissolves, swells or breaks in the skin and is absorbed by the skin, and the active ingredients are absorbed by the skin cells to repair damage and resist external light damage, which can quickly achieve the effect of beauty. .
- hydrophilically modified resveratrol and astaxanthin have better compatibility and skin permeability. On the basis of improving the percutaneous absorption effect of microneedle, the absorption rate of functional ingredients is further increased.
- the hydrophilically modified resveratrol is an inclusion compound formed by hydroxypropyl- ⁇ -cyclodextrin and resveratrol molecules.
- the mass ratio of the resveratrol to hydroxypropyl- ⁇ -cyclodextrin is (0.8-1.2): (9-12).
- the proportions by weight of each component in the composition are as follows:
- the total height of the microneedle patch is 200 ⁇ m-500 ⁇ m
- the height of the needle body is 30 ⁇ m-350 ⁇ m
- the size of the widest part of the interface of the needle body and the substrate is 100 ⁇ m-400 ⁇ m.
- the precise design controls the size of the needle body, so that the microneedle reaches between the epidermis layer and the dermis layer of the skin, so the needle will not cause pain or bleeding after the needle is inserted into the skin, so that the active ingredients are concentrated in the place where the effect needs to be exerted, and the needle hole can be quickly closure.
- the needle bodies are arranged on the surface of the substrate in an array, and the arrangement density of the array is 50-300 pieces/cm 2 .
- the microneedle patch is used on the eye or face, and the cosmetic benefit includes anti-photoaging.
- the present invention also provides a method for preparing the above-mentioned microneedle patch, which includes the following steps: injecting an aqueous solution of the composition into a mold, vacuuming, then removing water, and demoulding to obtain the microneedle patch.
- the preparation method of the aqueous solution of the composition comprises: dissolving hyaluronic acid or its salt in water, and then adding the astaxanthin, the hydrophilically modified resveratrol and the collagen to Among them, the mixing is uniform.
- the needle body is a cone, a quadrangular pyramid or a triangular pyramid.
- the present invention also provides a method for preparing a microneedle patch, which is characterized by comprising the following steps:
- the ethanol solution of resveratrol is added to the aqueous solution of hydroxypropyl- ⁇ -cyclodextrin, stirred and mixed, filtered and dried to obtain hydrophilic modified resveratrol;
- the aqueous solution of the composition is injected into the mold, vacuumed, and then water is removed, and the microneedle patch is obtained after demoulding.
- the mass ratio of the resveratrol to the hydroxypropyl- ⁇ -cyclodextrin is (0.8-1.2): (9-12).
- the proportions by weight of each component in the composition are as follows:
- the total height of the microneedle patch is 200 ⁇ m-500 ⁇ m
- the height of the needle body is 30 ⁇ m-350 ⁇ m
- the size of the widest part of the interface of the needle body and the substrate is 100 ⁇ m-400 ⁇ m.
- the needle body is a cone, a quadrangular pyramid or a triangular pyramid.
- the technical solution provided by the present invention is to make water-soluble microneedle patches from active ingredients with cosmetic functions.
- the microneedle patches significantly improve the stability of the active ingredients in the formula, and ensure that the mechanical strength of the microneedles is sufficient to pierce the keratin.
- the layer forms active ingredients to transport micro-channels, and transmits cosmetic active ingredients to the subcutaneous, so that it has anti-photoaging, repairing and anti-aging effects without toxic side effects.
- the active ingredients can not only produce synergistic effects, but also have good water solubility, Compared with the anti-photoaging patch in the prior art, the technical solution provided by the present invention has the advantages of high safety, high stability, good skin absorption, obvious cosmetic effect and the like.
- FIG. 1 is a schematic structural diagram of the microneedle patch described in Examples 1-3;
- Fig. 2 is the test result of the cytotoxicity of the microneedle patch described in Example 4.
- Fig. 3 is the test chart of the puncture force of aluminum foil paper in Example 5: a is the front side of the aluminum foil paper, b is the back side of the aluminum foil paper, c is the front side of the aluminum foil paper pierced by the microneedle patch, and d is the front side of the aluminum foil paper pierced by the microneedle patch aluminum foil back;
- Fig. 4 is a test chart of pigskin puncture force in Example 5: a is fresh pigskin, b is the microneedle patch pressed on the surface of the pigskin, c is the pigskin after removing the microneedle patch;
- Fig. 5 is the comparison chart of the stability of the hydrophilic modified resveratrol in the patch and the aqueous solution in Example 6, a is the UV spectrophotometer contrast spectrum of the patch after 0 days and 7 days, b is 0 Comparison of UV spectrophotometer spectra of aqueous solution after 1 day and 7 days;
- Fig. 6 is the comparison chart of the stability of astaxanthin in the patch and the aqueous solution in Example 6, a is the UV spectrophotometer contrast spectrum of the patch after 0 days and 6 days, b is the UV of the aqueous solution after 0 days and 6 days Spectrophotometer comparison spectrum;
- Figure 7 is a comparison diagram of the color changes of astaxanthin in the patch and the aqueous solution in Example 6, a is the color contrast between the two at 0 days, and b is the color contrast between the two at 6 days.
- microneedle patch and the preparation method thereof will be described below with reference to the examples. It should be understood that these examples are only used to illustrate the present invention and not to limit the scope of the present invention.
- the microneedle patch of the present invention is generally used for anti-aging beauty care of the skin exposed to sunlight, such as the face, eyes, neck, hands, etc., and can be designed as microneedle patches of different shapes and sizes as required. .
- the eye patch is taken as an example to illustrate the structure of the microneedle patch, which includes a base 10 and a plurality of needle bodies 20 arranged in an array on the surface of the base 10.
- the The needle body is a solid cone, of course, it can be a quadrangular pyramid, a triangular pyramid or a cone with more faces, and it can also be a cone with a hollow structure.
- the total height of the microneedle patch is 200-500 ⁇ m, the height of the needle body is 30-350 ⁇ m, and the size of the widest part of the interface between the needle body and the substrate (for example, the diameter of the bottom surface of the conical needle body) It is 100-400 ⁇ m, and the arrangement density is 50-300 pieces/cm 2 .
- the total height of the microneedle patch refers to the straight-line distance from the bottom of the base to the top of the needle body, and the height of the needle body is the straight-line distance from the bottom to the top of the pointer body.
- Examples 1-3 the specific dimensions of the microneedle patch are shown in Table 1.
- the preparation method of the microneedle patch comprises the following steps:
- resveratrol hydroxypropyl- ⁇ -cyclodextrin and resveratrol molecules form inclusion complexes;
- composition solution Dissolve hyaluronic acid in water, stir for about 0.5 hours to a clear and uniform state, and then add astaxanthin, the hydrophilically modified resveratrol prepared in step 1) and collagen in turn. , stir evenly, wherein the proportions of astaxanthin, hydrophilic modified resveratrol, collagen and hyaluronic acid by weight are as follows:
- Microneedle patch molding injecting the composition solution prepared in step 2) into a microneedle mold, vacuuming, drying and removing water, and demoulding to obtain the microneedle patch.
- the proportion of each raw material component by weight and the axial pressure of a single needle in the prepared microneedle patch are as shown in Table 2, and it can be seen that the microneedle has high mechanical strength.
- the axial pressure test method of the single needle is: press the needle body with a flat indenter, record the axial force at different displacements, the effective area of the flat indenter is 0.25 square centimeters, and under the effective area, there are about 25 Needle, when the displacement of the indenter is 0.2mm, the axial pressure of a single needle is calculated from the recorded axial force.
- the test object is the cytotoxicity of the microneedle patch prepared in Example 3.
- microneedle patch of Example 3 with a thickness of 0.12 mm and a mass of 400 mg was dissolved in 4 mL of cell culture medium, and mouse fibroblasts (L929 cells) were selected to test the cytotoxicity of the microneedle patch, as shown in Figure 2
- the blank control is the same batch of culture medium;
- the positive control is the cytotoxicity of 14% DMSO;
- the patch is the lysate of the microneedle patch of Example 3.
- the results show that the microneedle patch is completely non-toxic and can be safely used for internal absorption in the skin.
- microneedle patch prepared in Example 3 was cut into a circle with a diameter of 1 cm and pressed on the aluminum foil paper for 30 seconds, and the results of piercing the aluminum foil paper were observed and recorded. Wearing aluminum foil paper proves that the microneedle patch for anti-photoaging of the present invention has certain mechanical strength.
- microneedle patch prepared in Example 3 dyed with methylene blue was again cut into a circle with a diameter of 1 cm and pressed on the fresh pig skin that had been treated and the subcutaneous fat was removed for 40 seconds to remove the microneedle patch.
- Figure 4 observe the dyeing situation of pigskin, it is found that the pigskin after removing the microneedle patch has been punctured, and the microneedle patch of the present invention can be known from the puncture experiment that there is enough machinery to pierce the skin. strength.
- Astaxanthin and resveratrol are easily oxidized and are very unstable in water and emulsions. Since resveratrol is immiscible with water, in order to compare the differences in stability between the two in the patch and solution state, first of all resveratrol Hydrophilic modification of atrol, astaxanthin and hydrophilically modified resveratrol are made into patches, and at the same concentration, an aqueous solution of astaxanthin and hydrophilically modified resveratrol is prepared. For comparison, the patch configuration for testing stability is shown in Table 3.
- the patch sample 1 was placed at room temperature for 7 days under the condition of no light, and the results of UV spectrophotometer detection showed that the content of resveratrol in the patch did not change significantly between time 0 and 7 days, while Under the same conditions, the content of resveratrol in the aqueous solution after 7 days of hydrophilic modification is lower than 0 time, indicating that the stability of the active ingredient of resveratrol in patch sample 1 is better than that in the aqueous solution .
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Abstract
Description
Claims (13)
- 一种微针贴片,其特征在于,包括基底和设置在所述基底表面的若干针体,所述针体为可溶性锥体,所述针体含具有美容功效的组合物,所述组合物包括虾青素、亲水改性的白藜芦醇、胶原蛋白和透明质酸。
- 根据权利要求1所述的微针贴片,其特征在于,所述亲水改性的白藜芦醇为羟丙基-β-环糊精与白藜芦醇分子形成的包合物。
- 根据权利要求2所述的微针贴片,其特征在于,所述白藜芦醇与羟丙基-β-环糊精的质量比为(0.8~1.2):(9~12)。
- 根据权利要求1所述的微针贴片,其特征在于,所述微针贴片的总高度为200μm-500μm,所述针体的高度为30μm-350μm,所述针体与所述基底相接面最宽处的尺寸为100μm-400μm。
- 根据权利要求1所述的微针贴片,其特征在于,所述针体以阵列形式排布在所述基底的表面,所述阵列的排布密度为50-300个/cm 2。
- 根据权利要求1-6任一所述的微针贴片,其特征在于,所述微针贴片用于眼部或面部,所述美容功效包括抗光老化。
- 根据权利要求1所述的微针贴片,其特征在于,所述针体为圆锥体、四棱锥体或三角锥体。
- 一种微针贴片的制备方法,其特征在于,包括如下步骤:将白藜芦醇的乙醇溶液加入到羟丙基-β-环糊精的水溶液中,搅拌混合,过滤后干燥,获得亲水改性的白藜芦醇;将透明质酸、虾青素、所述亲水改性的白藜芦醇以及胶原蛋白依次加入水中并搅拌均匀,形成组合物的水溶液;将所述组合物的水溶液注入模具中,抽真空,然后除水,脱模后得到所述微针贴片。
- 根据权利要求9所述的制备方法,其特征在于,所述白藜芦醇与所述羟丙基-β-环糊精的质量比为(0.8~1.2):(9~12)。
- 根据权利要求9所述的制备方法,其特征在于,所述微针贴片的总高度为200μm-500μm,所述针体的高度为30μm-350μm,所述针体与所述基底相接面最宽处的尺寸为100μm-400μm。
- 根据权利要求9所述的制备方法,其特征在于,所述针体为圆锥体、四棱锥体或三角锥体。
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CN104066475A (zh) * | 2012-02-17 | 2014-09-24 | 考司美德制药株式会社 | 迅速溶解型微针 |
CN104411207A (zh) * | 2012-06-29 | 2015-03-11 | Elc管理有限责任公司 | 包含一种或多种包封化妆品成分的可溶解微针 |
CN110037938A (zh) * | 2019-03-06 | 2019-07-23 | 胡婧 | 一种玻尿酸微针贴片及其制备方法 |
CN111278499A (zh) * | 2017-11-02 | 2020-06-12 | 日写株式会社 | 微针片及其制造方法 |
CN111920699A (zh) * | 2020-09-14 | 2020-11-13 | 广州新济薇娜生物科技有限公司 | 美白祛斑组合物、美白祛斑可溶性微针贴片及其制备方法 |
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CN104066475A (zh) * | 2012-02-17 | 2014-09-24 | 考司美德制药株式会社 | 迅速溶解型微针 |
CN104411207A (zh) * | 2012-06-29 | 2015-03-11 | Elc管理有限责任公司 | 包含一种或多种包封化妆品成分的可溶解微针 |
CN111278499A (zh) * | 2017-11-02 | 2020-06-12 | 日写株式会社 | 微针片及其制造方法 |
CN110037938A (zh) * | 2019-03-06 | 2019-07-23 | 胡婧 | 一种玻尿酸微针贴片及其制备方法 |
CN111920699A (zh) * | 2020-09-14 | 2020-11-13 | 广州新济薇娜生物科技有限公司 | 美白祛斑组合物、美白祛斑可溶性微针贴片及其制备方法 |
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CN116548205A (zh) * | 2023-04-24 | 2023-08-08 | 南京师范大学 | 微针制剂、微针贴片及其制备方法和应用 |
CN116548205B (zh) * | 2023-04-24 | 2024-02-13 | 南京师范大学 | 微针制剂、微针贴片及其制备方法和应用 |
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