WO2022139460A1 - Composition comprising euphrasia pectinata extract for alleviation of hair loss and promotion of hair regrowth - Google Patents
Composition comprising euphrasia pectinata extract for alleviation of hair loss and promotion of hair regrowth Download PDFInfo
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- WO2022139460A1 WO2022139460A1 PCT/KR2021/019610 KR2021019610W WO2022139460A1 WO 2022139460 A1 WO2022139460 A1 WO 2022139460A1 KR 2021019610 W KR2021019610 W KR 2021019610W WO 2022139460 A1 WO2022139460 A1 WO 2022139460A1
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- hair
- extract
- composition
- hair loss
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Images
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
Definitions
- the present invention relates to a food composition for improving hair loss or promoting hair growth, comprising a Somicho extract, a cosmetic composition, a feed composition, and a pharmaceutical composition for preventing or treating hair loss disease, including a Somicho extract;
- a method for preventing or treating hair loss disease comprising administering to an individual a composition comprising a Somicho extract as an active ingredient;
- it relates to a food composition, a cosmetic composition, a feed composition comprising a Somicho extract, to improve hair loss or to promote hair growth, and to a preventive or therapeutic use for a hair loss disease of a pharmaceutical composition comprising the Somicho extract.
- Hair loss refers to a state in which there is no hair in the area where hair should normally exist, and it means the hair loss of the scalp.
- hair loss symptoms 29% of adult males and 15% of females answered that they are currently experiencing hair loss symptoms, and 49% of males and 27% of females in their 60s or older responded that they were experiencing hair loss symptoms. .
- 47% of those who currently experienced hair loss symptoms felt that hair loss was serious, indicating that the need for hair loss treatment was great (Gallup Korea, Research on Hair Loss - 2013/2019 comparison). So far, minoxidil, Propecia (Finasteride), and Dutasteride (Dutasteride) have been approved as hair loss treatments at home and abroad, and are being used to treat hair loss patients.
- Somicho ( ⁇ , Euphrasia pectinata ) is a plant belonging to the genus Milletae, and it has been reported on the effect of inhibiting cancer cell proliferation, etc. (Phytochemistry Letters 12, 2015, 252-256). has not been studied at all.
- the present inventors have completed the present invention by confirming that the Somicho extract has remarkable effects on improving hair loss and promoting hair growth.
- It is an object of the present invention to provide a food composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient.
- Another object of the present invention is to provide a cosmetic composition for improving hair loss or promoting hair growth, comprising a Somicho extract as an active ingredient.
- Another object of the present invention is to provide a feed composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient.
- Another object of the present invention is to provide a pharmaceutical composition for preventing or treating hair loss disease comprising a Somicho extract as an active ingredient.
- Another object of the present invention is to provide a method for preventing or treating hair loss disease comprising administering to an individual a composition comprising a Somicho extract as an active ingredient.
- Another object of the present invention is to provide a use for improving hair loss or promoting hair growth of a food composition comprising a Somicho extract as an active ingredient.
- Another object of the present invention is to provide a use for improving hair loss or promoting hair growth of a cosmetic composition comprising a Somicho extract as an active ingredient.
- Another object of the present invention is to provide a use for improving hair loss or promoting hair growth of a feed composition comprising a Somicho extract as an active ingredient.
- Another object of the present invention is to provide a use for preventing or treating hair loss disease of a pharmaceutical composition comprising a Somicho extract as an active ingredient.
- the Somicho extract of the present invention increases the growth rate of human-derived dermal papilla cells and has an excellent hair loss improvement and hair growth promoting effect, so it can be used as a drug, food, health functional food, cosmetic, etc. effective for preventing and treating hair loss.
- 1 is a diagram showing the results of comparison of the effect of increasing human dermal papilla cell proliferation by a somicho extract or minoxidil (MX) treatment.
- One aspect of the present invention for achieving the above object provides a food composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient.
- Another aspect of the present invention provides a cosmetic composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient
- Another aspect of the present invention provides a feed composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient.
- Somi-cho ( ⁇ ) of the present invention is a plant belonging to the genus Euphrasia of the family Orobanchaceae, specifically, Euphrasia pectinata , Euphrasia officinalis , Or Euphrasia regelii ( Euphrasia regelii ) It may be, but is not limited thereto.
- Somi vinegar of the present invention may be harvested from nature or purchased commercially, but is not limited thereto.
- the effect of promoting the proliferation of dermal papilla cells was confirmed, and the effect was confirmed to be similar to or superior to minoxidil marketed as a hair loss treatment agent (Example 2), somicho It was identified for the first time that the extract can be used for improving hair loss or promoting hair growth.
- the Somicho extract of the present invention refers to the form of the extract obtained by extraction with one or more solvents, and the solvent used for the preparation of the extract includes water, carbon number 1 (C 1 ) to carbon number 6 (C 6 ) alcohol, Preferably, ethanol, methanol or butanol, an organic solvent, or a mixed solvent thereof may be used, but is not limited thereto.
- the extraction method methods such as solvent extraction, hot water extraction, cold extraction, reflux cooling extraction, ultrasonic extraction, or steam extraction may be used, but are not limited thereto.
- the Somicho extract of the present invention may be extracted with ethanol, for example, may be extracted with 60 to 80% ethanol.
- reflux extraction was performed using 70% ethanol, but the present invention is not limited thereto.
- “Improving hair loss” of the present invention refers to a process of treating, alleviating, alleviating a hair loss condition, or its effect, and the like, and may mean any action that inhibits the progress of hair loss.
- “Promoting hair growth” of the present invention means any action that increases hair growth from the hair follicle, and may mean any action that increases the total amount of hair.
- the hair loss improvement or hair growth promotion may be achieved by promoting the activity of dermal papilla cells, promoting proliferation, or inhibiting apoptosis.
- Hair follicle a physiological organ in the body that produces hair, is the anagen phase, in which the hair is generated and generated, actively growing, the catagen phase, in which the hair is degenerated, and the resting phase (hair follicle) maintained until shedding It is involved in hair growth, maintenance, and loss while repeating the hair cycle, divided into the telogen phase) and the exogen phase in which hair loss occurs.
- the activity of this hair follicle is caused by the hair papilla cells, and in particular, the proliferation and differentiation of the hair papilla cells is primarily involved in the progression of the hair growth cycle and hair formation.
- hair growth and hair loss are closely related to the proliferation and death of hair papilla cells. Therefore, prolonging the growth phase or inhibiting apoptosis by inducing the proliferation of dermal papilla cells and shortening the catagen phase, resting phase, and hair loss phase improves hair loss and It could be a treatment option.
- cell division and migration in the vicinity of nipples are closely related to hair growth. Cells are activated by various cytokines and hormones, so cells move to nipples and affect hair growth. Therefore, proliferation of dermal papilla cells is a very important factor in suppressing hair loss and hair growth.
- composition comprising the Somicho extract of the present invention significantly increases the proliferative power of dermal papilla cells (Example 2), it can be used to improve hair loss or promote hair growth.
- the composition of the present invention may be a food composition, a cosmetic composition, or a feed composition.
- the composition may further include a pharmaceutically acceptable carrier, and may be formulated with a carrier and provided as food, cosmetics and feed.
- the “food” of the present invention includes meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gum, and dairy products including ice cream, various soups, beverages, tea, drinks, alcoholic beverages, vitamins It includes all foods in the usual sense, such as complexes and health functional foods, and is not limited thereto as long as it can contain the Somicho extract of the present invention.
- it can be prepared by adding the Somicho extract of the present invention to juice, tea, jelly and juice, etc.
- the food composition of the present invention can be prepared in the form of powder, granule, tablet, capsule, pill, or liquid, but this not limited
- the food composition when the food composition is prepared, it can be prepared by adding raw materials and components commonly added in the art, and the type is not particularly limited. For example, it may include, as an additional ingredient, various herbal extracts, food-logically acceptable food supplements or natural carbohydrates, such as conventional food, but is not limited thereto.
- health functional food means a food manufactured and processed using raw materials or ingredients useful for the human body according to the Health Functional Food Act No. 6727, , 'functionality' refers to obtaining useful effects for health purposes such as regulating nutrients or physiological effects on the structure and function of the human body.
- health food means food that has an active health maintenance or promotion effect compared to general food
- health supplement means food for the purpose of health supplementation.
- the terms health functional food, health food and health supplement food can be mixed.
- the food composition of the present invention may be added as it is or used together with other foods or food ingredients, and may be appropriately used according to a conventional method.
- the health functional food composition of the present invention can be prepared by a method commonly used in the art, and at the time of manufacture, it can be prepared by adding raw materials and components commonly added in the art.
- the health functional food composition may further include a physiologically acceptable carrier, the type of carrier is not particularly limited and any carrier commonly used in the art may be used.
- the health functional food composition is a food such as a preservative, a disinfectant, an antioxidant, a colorant, a coloring agent, a bleaching agent, a seasoning, a sweetener, a flavoring, an expanding agent, a strengthening agent, an emulsifier, a thickener, a film agent, a gum base agent, a foam inhibitor, a solvent, an improving agent, etc. It may contain additives.
- the additive may be selected according to the type of food and used in an appropriate amount.
- the formulation of the health functional food may be manufactured without limitation as long as it is a formulation recognized as a food.
- cosmetic composition refers to solutions, external ointments, creams, foams, nourishing lotions, softening lotions, packs, softening water, emulsions, makeup bases, essences, soaps, liquid detergents, bathing agents, sunscreen creams, sun oils, Suspension, emulsion, paste, gel, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, patch and spray, specifically As such, it may be prepared in the form of an external preparation for skin, but is not limited thereto.
- the external preparation for skin includes hair tonic, hair cream, hair lotion, hair shampoo, hair conditioner, hair conditioner, hair spray, hair aerosol, pomade, powder, gel, hair pack, hair treatment, eyebrow hair growth agent, eyelash hair growth agent, and It may be selected from the group consisting of eyelash nutrients, but is not limited thereto.
- the cosmetic composition of the present invention may further include one or more cosmetically acceptable carriers to be formulated in general skin cosmetics, and conventional ingredients include, for example, oil, water, surfactant, humectant, lower alcohol, A thickener, a chelating agent, a colorant, a preservative, a fragrance, etc. may be appropriately mixed, but is not limited thereto.
- the cosmetically acceptable carrier included in the cosmetic composition of the present invention varies depending on the formulation.
- the cosmetic composition of the present invention includes, in addition to the Somicho extract, commonly used auxiliary agents, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preservatives, antioxidants, solvents, fragrances, fillers, blocking agents, pigments, odorants, and dyes and the like.
- auxiliary agents such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preservatives, antioxidants, solvents, fragrances, fillers, blocking agents, pigments, odorants, and dyes and the like.
- feed of the present invention refers to any natural or artificial diet, one meal, etc. or a component of the one meal meal suitable for or suitable for eating, ingestion, and digestion by animals, a feed containing the extract of the present invention.
- a feed containing the extract of the present invention can be prepared in various types of feed known in the art, specifically, it may include a concentrated feed, roughage or special feed.
- the breeding target may be included without limitation as long as it is an organism capable of ingesting the feed of the present invention.
- the feed composition of the present invention may further include organic acids such as citric acid, fumaric acid, adipic acid, and lactic acid for administration; phosphates such as potassium phosphate, sodium phosphate, and polymerized phosphate; One or more of natural antioxidants such as polyphenol, catechin, tocopherol, vitamin C, green tea extract, chitosan, and tannic acid can be mixed and used. can do.
- diluents, dispersants, surfactants, binders or lubricants may be additionally added to form an injectable formulation such as an aqueous solution, suspension, emulsion, etc., capsules, granules or tablets.
- the feed composition of the present invention includes various auxiliary agents such as amino acids, inorganic salts, vitamins, antioxidants, antifungals, and antibacterial agents as auxiliary components, and plant protein feed such as milled or crushed wheat, barley, and corn, blood meal, meat meal, fish meal, etc.
- auxiliary agents such as amino acids, inorganic salts, vitamins, antioxidants, antifungals, and antibacterial agents
- plant protein feed such as milled or crushed wheat, barley, and corn, blood meal, meat meal, fish meal, etc.
- main ingredients such as animal protein feed, animal fat and vegetable fat, it can be used together with nutritional supplements, growth promoters, digestion and absorption promoters, and disease prevention agents.
- the feed composition comprising the Somicho extract of the present invention as an active ingredient can be used to improve hair loss or promote hair growth in breeding subjects.
- Another aspect of the present invention provides a pharmaceutical composition for preventing or treating hair loss disease comprising a Somicho extract as an active ingredient.
- the hair loss of the present invention means a state in which there is no hair in a part where hair should normally exist, and specifically, it may mean that the hair (thick and dark hair) of the scalp falls out.
- the cause of hair loss is not limited, but may be caused by various dietary and environmental influences such as genetic causes, hormonal imbalance, mental stress, exposure to air pollution, and intake of processed foods.
- the hair loss includes hereditary androgenetic alopecia (baldness), circular alopecia, ringworm of the head due to fungal infection, telogen alopecia, hair growth wall, hair growth disorder diseases, etc. It can mean hair loss due to alopecia, solitary folliculitis, lichen planus pilaris, burns and trauma hair loss.
- the term “treatment” refers to clinical intervention to alter the natural process of an individual or cell to be treated, which may be performed during the course of or to prevent a clinical pathology.
- the desired therapeutic effect includes preventing the occurrence or recurrence of a disease, alleviating symptoms, reducing any direct or indirect pathological consequences of the disease, preventing metastasis, reducing the rate of disease progression, and alleviating the disease state. or temporary relief, remission or improvement of prognosis.
- it includes all acts of improving the course of hair loss by administering a composition comprising a Somicho extract as an active ingredient.
- prevention of the present invention means any action that inhibits or delays the onset of the hair loss disease by administration of a composition comprising the Somicho extract according to the present invention as an active ingredient.
- the pharmaceutical composition of the present invention may exhibit a preventive or therapeutic effect for hair loss disease by increasing the proliferative power of dermal papilla cells.
- compositions may further include an appropriate carrier, excipient or diluent commonly used in the preparation of pharmaceutical compositions.
- the composition comprising a pharmaceutically acceptable carrier may be in various oral or parenteral dosage forms. In the case of formulation, it can be prepared using a diluent or excipient such as a filler, extender, binder, wetting agent, disintegrant, surfactant, etc. commonly used.
- Solid preparations for oral administration may include tablet pills, powders, granules, capsules, etc., and these solid preparations include at least one excipient in one or more compounds, for example, starch, calcium carbonate, sucrose or lactose. It can be prepared by mixing (lactose), gelatin, etc.
- Liquid preparations for oral administration include suspensions, internal solutions, emulsions, syrups, etc.
- simple diluents such as water and liquid paraffin
- various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included.
- Formulations for parenteral administration may include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, lyophilized formulations, and suppositories.
- Non-aqueous solvents and suspensions may include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate.
- injectable esters such as ethyl oleate.
- base of the suppository witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, and the like can be used.
- the pharmaceutical composition of the present invention is not limited thereto, but tablets, pills, powders, granules, capsules, suspensions, internal solutions, emulsions, syrups, sterilized aqueous solutions, non-aqueous solvents, suspensions, emulsions, freeze-dried preparations and It may have any one formulation selected from the group consisting of suppositories.
- Another aspect of the present invention provides a method for preventing or treating hair loss disease comprising administering to an individual a composition comprising a Somicho extract as an active ingredient.
- the term "individual” may refer to all animals, including humans, who have or are likely to become bald.
- the animal may be a mammal, such as a cow, a horse, a sheep, a pig, a goat, a camel, an antelope, a dog, or a cat, in need of treatment for symptoms similar to those of a human as well as humans, but is not limited thereto.
- the prevention or treatment method of the present invention may include the step of administering the composition in a pharmaceutically effective amount to an individual who has become or is likely to become a hair loss state.
- the term "administration” means introducing the pharmaceutical composition of the present invention to a patient by any suitable method, and the administration route of the composition of the present invention may be oral or parenteral as long as it can reach the target tissue. It may be administered via a route.
- Another aspect of the present invention provides a use for improving hair loss or promoting hair growth of a food composition comprising a Somicho extract as an active ingredient.
- Another aspect of the present invention provides a use for improving hair loss or promoting hair growth of a cosmetic composition comprising a Somicho extract as an active ingredient.
- Another aspect of the present invention provides a use for improving hair loss or promoting hair growth of a feed composition comprising a Somicho extract as an active ingredient.
- Another aspect of the present invention provides a use for preventing or treating hair loss disease of a pharmaceutical composition comprising a Somicho extract as an active ingredient.
- the ethanol extract of Somicho was treated with human dermal papilla cells (HDPC) to measure cell proliferation, and the existing hair loss treatment agent The efficacy was compared with phosphorus minoxidil (MX: Minoxidil).
- Human dermal papilla cells were treated with 70% somicholic alcohol extract or minoxidil (MX), respectively, and cell proliferation ability was confirmed through WST Assay. Specifically, human dermal papilla cells were seeded in a 96-well plate using DMEM medium containing 10% (v/v) FBS and 1% (v/v) penicillin/streptomycin under 5% CO 2 and 37° C. conditions. After that, 37 °C, 5% CO 2 Incubated in an incubator for 24 hours. Then, the medium was treated with the alcohol extract of Somicho of Example 1 at a concentration of 5, 10, or 50 ⁇ g/mL, and minoxidil was treated with a concentration of 5 and 10 ⁇ M.
- MX somicholic alcohol extract
- MX minoxidil
- CCK D-Plus TM CCK cell viability assay kit
Abstract
The present invention relates to: a food composition, a cosmetic composition, and a feed composition for alleviation of hair loss or promotion of hair regrowth, and a pharmaceutical composition for prevention or treatment of a hair loss disease, each composition comprising an Euphrasia pectinata extract; a method for prevention or treatment of a hair loss disease, the method comprising a step of administering to a subject a composition comprising a Euphrasia pectinata extract as an active ingredient; and a use of a food composition, a cosmetic composition, and a feed composition for alleviating hair loss or promoting hair regrowth, and a use of a pharmaceutical composition for preventing or treating a hair loss disease, each composition comprising an Euphrasia pectinata extract. The Euphrasia pectinata extract of the present invention increases the growth rate of human body-derived dermal papilla cells to exhibit excellent effects of alleviating hair loss and promoting hair regrowth and as such, can be utilized in drugs, foods, health functional foods, cosmetics, and so on which are effective for prevention and treatment of hair loss.
Description
본 발명은 소미초 추출물을 포함하는 탈모 개선 또는 발모 촉진용 식품 조성물, 화장료 조성물, 사료 조성물, 및 소미초 추출물을 포함하는 탈모 질환의 예방 또는 치료용 약학 조성물; 소미초 추출물을 유효성분으로 포함하는 조성물을 개체에 투여하는 단계를 포함하는 탈모 질환의 예방 또는 치료방법; 및 소미초 추출물을 포함하는 식품 조성물, 화장료 조성물, 사료 조성물의 탈모 개선 또는 발모 촉진용도 및 소미초 추출물을 포함하는 약학 조성물의 탈모 질환의 예방 또는 치료용도에 관한 것이다.The present invention relates to a food composition for improving hair loss or promoting hair growth, comprising a Somicho extract, a cosmetic composition, a feed composition, and a pharmaceutical composition for preventing or treating hair loss disease, including a Somicho extract; A method for preventing or treating hair loss disease, comprising administering to an individual a composition comprising a Somicho extract as an active ingredient; And it relates to a food composition, a cosmetic composition, a feed composition comprising a Somicho extract, to improve hair loss or to promote hair growth, and to a preventive or therapeutic use for a hair loss disease of a pharmaceutical composition comprising the Somicho extract.
탈모는 정상적으로 모발이 존재해야 할 부위에 모발이 없는 상태를 말하며, 두피의 성모가 빠지는 것을 의미한다. 2019년 설문조사에서는 성인 남성의 29%, 여성의 15%가 '현재 탈모 증상을 겪고 있다'고 응답했으며, 60대 이상 고연령에서는 남성의 49%, 여성의 27%가 탈모 증상을 겪고 있다고 응답하였다. 또한, 현재 탈모 증상 경험자의 47%가 탈모가 심각하다고 느껴 탈모 치료의 필요성이 큰 것으로 나타났다 (한국갤럽, 탈모에 대한 조사 - 2013/2019년 비교). 현재까지 국내외에서 미녹시딜(minoxidil)과 프로페시아(Finasteride), 두타스테라이드(Dutasteride)가 탈모치료제로 승인 받아 탈모 환자의 치료에 사용되고 있다. 그러나 시판 제제인 프로페시아와 두타스테라이드는 발기부전, 성욕감소, 사정장애, 유방 압통과 유방 비대를 포함하는 여성형 유방 등의 부작용이 보고되어 있으며, 임산부가 복용하는 경우 남성태아 외부 생식기의 비정상을 초래할 수 있어 임산부 또는 임신 가능성이 있는 여성은 사용할 수 없다는 한계가 있다. 또한, 미녹시딜의 경우 경구 투여시 수액정체, 빈맥, 오심, 호흡곤란 및 남성에게서 여성형 유방 등의 부작용이 보고되어 있으며, 환부에 장기간 도포시 두피건조, 소양감, 홍반 등의 두피자극 증상 및 알레르기성 접촉 피부염 등의 부작용도 보고되어 있다 (Recent Patents on Inflammation & Allergy Drug Discovery 6(2), 2012, 130-136). 아울러, 미녹시딜은 탈모의 진행을 늦추기는 하지만 굵은 털이 길게 자라는 효과를 기대하기 어렵고, 완전히 탈모가 진행된 사람에서는 만족할 만한 결과를 기대하기 어렵다. 따라서, 기존에 허가 받은 탈모치료제와 효과가 유사하거나 더 뛰어나고, 두피 자극, 피부염, 성기능 장애 등의 부작용이 없는 탈모치료제 개발을 위해 상대적으로 안전성이 검증된 천연물을 이용하는 연구가 활발히 진행되고 있다.Hair loss refers to a state in which there is no hair in the area where hair should normally exist, and it means the hair loss of the scalp. In the 2019 survey, 29% of adult males and 15% of females answered that they are currently experiencing hair loss symptoms, and 49% of males and 27% of females in their 60s or older responded that they were experiencing hair loss symptoms. . In addition, 47% of those who currently experienced hair loss symptoms felt that hair loss was serious, indicating that the need for hair loss treatment was great (Gallup Korea, Research on Hair Loss - 2013/2019 comparison). So far, minoxidil, Propecia (Finasteride), and Dutasteride (Dutasteride) have been approved as hair loss treatments at home and abroad, and are being used to treat hair loss patients. However, commercial preparations such as Propecia and Dutasteride have reported side effects such as erectile dysfunction, decreased libido, ejaculation disorders, breast tenderness and gynecomastia including breast enlargement. Therefore, there is a limitation that it cannot be used by pregnant women or women of childbearing potential. In the case of minoxidil, side effects such as fluid retention, tachycardia, nausea, dyspnea and gynecomastia have been reported in men when administered orally. Side effects such as dermatitis have also been reported (Recent Patents on Inflammation & Allergy Drug Discovery 6(2), 2012, 130-136). In addition, although minoxidil slows the progress of hair loss, it is difficult to expect the effect of growing thick hair long, and it is difficult to expect satisfactory results in people with complete hair loss. Therefore, research using natural products with relatively proven safety is being actively conducted to develop a hair loss treatment agent that has similar or superior effects to previously approved hair loss treatment agents and does not have side effects such as scalp irritation, dermatitis, and sexual dysfunction.
한편, 소미초(小米草, Euphrasia pectinata)는 좁쌀풀속에 속하는 식물로서, 소미초의 암세포 증식 억제 효과 등에 대해서는 보고되었으나 (Phytochemistry Letters 12, 2015, 252-256), 소미초의 탈모 개선 또는 발모 촉진 효과에 대해서는 전혀 연구된 바 없다.On the other hand, Somicho ( 小米草 , Euphrasia pectinata ) is a plant belonging to the genus Milletae, and it has been reported on the effect of inhibiting cancer cell proliferation, etc. (Phytochemistry Letters 12, 2015, 252-256). has not been studied at all.
본 발명자들은 소미초 추출물이 탈모 개선 및 발모 촉진 효능이 현저함을 확인함으로써, 본 발명을 완성하였다.The present inventors have completed the present invention by confirming that the Somicho extract has remarkable effects on improving hair loss and promoting hair growth.
본 발명의 목적은 소미초 추출물을 유효성분으로 포함하는 탈모 개선 또는 발모 촉진용 식품 조성물을 제공하는 것이다.It is an object of the present invention to provide a food composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient.
본 발명의 다른 하나의 목적은 소미초 추출물을 유효성분으로 포함하는 탈모 개선 또는 발모 촉진용 화장료 조성물을 제공하는 것이다.Another object of the present invention is to provide a cosmetic composition for improving hair loss or promoting hair growth, comprising a Somicho extract as an active ingredient.
본 발명의 또 다른 하나의 목적은 소미초 추출물을 유효성분으로 포함하는 탈모 개선 또는 발모 촉진용 사료 조성물을 제공하는 것이다.Another object of the present invention is to provide a feed composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient.
본 발명의 또 다른 하나의 목적은 소미초 추출물을 유효성분으로 포함하는 탈모 질환의 예방 또는 치료용 약학 조성물을 제공하는 것이다. Another object of the present invention is to provide a pharmaceutical composition for preventing or treating hair loss disease comprising a Somicho extract as an active ingredient.
본 발명의 또 다른 하나의 목적은 소미초 추출물을 유효성분으로 포함하는 조성물을 개체에 투여하는 단계를 포함하는 탈모 질환의 예방 또는 치료방법을 제공하는 것이다. Another object of the present invention is to provide a method for preventing or treating hair loss disease comprising administering to an individual a composition comprising a Somicho extract as an active ingredient.
본 발명의 또 다른 하나의 목적은 소미초 추출물을 유효성분으로 포함하는 식품 조성물의 탈모 개선 또는 발모 촉진용도를 제공하는 것이다.Another object of the present invention is to provide a use for improving hair loss or promoting hair growth of a food composition comprising a Somicho extract as an active ingredient.
본 발명의 또 다른 하나의 목적은 소미초 추출물을 유효성분으로 포함하는 화장료 조성물의 탈모 개선 또는 발모 촉진용도를 제공하는 것이다.Another object of the present invention is to provide a use for improving hair loss or promoting hair growth of a cosmetic composition comprising a Somicho extract as an active ingredient.
본 발명의 또 다른 하나의 목적은 소미초 추출물을 유효성분으로 포함하는 사료 조성물의 탈모 개선 또는 발모 촉진용도를 제공하는 것이다.Another object of the present invention is to provide a use for improving hair loss or promoting hair growth of a feed composition comprising a Somicho extract as an active ingredient.
본 발명의 또 다른 하나의 목적은 소미초 추출물을 유효성분으로 포함하는 약학 조성물의 탈모 질환의 예방 또는 치료용도를 제공하는 것이다. Another object of the present invention is to provide a use for preventing or treating hair loss disease of a pharmaceutical composition comprising a Somicho extract as an active ingredient.
본 발명의 소미초 추출물은 인체 유래 모유두세포의 생장률을 증가시켜 우수한 탈모 개선 및 발모 촉진 효과를 가지는 바, 탈모 예방 및 치료에 유효한 약품, 식품, 건강기능식품, 화장품 등으로 활용될 수 있다. The Somicho extract of the present invention increases the growth rate of human-derived dermal papilla cells and has an excellent hair loss improvement and hair growth promoting effect, so it can be used as a drug, food, health functional food, cosmetic, etc. effective for preventing and treating hair loss.
도 1은 소미초 추출물 또는 미녹시딜(MX) 처리에 의한 인간 모유두세포 증식능 증가 효과를 비교한 결과를 나타낸 도이다.1 is a diagram showing the results of comparison of the effect of increasing human dermal papilla cell proliferation by a somicho extract or minoxidil (MX) treatment.
이를 구체적으로 설명하면 다음과 같다. 한편, 본 발명에서 개시된 각각의 설명 및 실시형태는 각각의 다른 설명 및 실시형태에도 적용될 수 있다. 즉, 본 발명에서 개시된 다양한 요소들의 모든 조합이 본 발명의 범주에 속한다. 또한, 하기 기술된 구체적인 서술에 의하여 본 발명의 범주가 제한된다고 볼 수 없다.This will be described in detail as follows. Meanwhile, each description and embodiment disclosed in the present invention may be applied to each other description and embodiment. That is, all combinations of the various elements disclosed herein fall within the scope of the present invention. In addition, it cannot be considered that the scope of the present invention is limited by the specific descriptions described below.
또한, 당해 기술분야의 통상의 지식을 가진 자는 통상의 실험만을 사용하여 본 발명에 기재된 본 발명의 특정 양태에 대한 다수의 등가물을 인지하거나 확인할 수 있다. 또한, 이러한 등가물은 본 발명에 포함되는 것으로 의도된다.In addition, those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Also, such equivalents are intended to be encompassed by the present invention.
상기 목적을 달성하기 위한 본 발명의 하나의 양태는 소미초 추출물을 유효성분으로 포함하는 탈모 개선 또는 발모 촉진용 식품 조성물을 제공한다.One aspect of the present invention for achieving the above object provides a food composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient.
본 발명의 다른 하나의 양태는 소미초 추출물을 유효성분으로 포함하는 탈모 개선 또는 발모 촉진용 화장료 조성물을 제공한다Another aspect of the present invention provides a cosmetic composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient
본 발명의 또 다른 하나의 양태는 소미초 추출물을 유효성분으로 포함하는 탈모 개선 또는 발모 촉진용 사료 조성물을 제공한다.Another aspect of the present invention provides a feed composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient.
본 발명의 소미초(小米草)는 열당과(Orobanchaceae) 좁쌀풀속(Euphrasia)에 속하는 식물로서, 구체적으로, 유프라시아 펙티나타(Euphrasia pectinata), 유프라시아 오피시날리스(Euphrasia officinalis), 또는 유프라시아 레겔리(Euphrasia regelii)일 수 있으나, 이에 제한되지 않는다. 본 발명의 소미초는 자연에서 채취하거나, 상업적으로 판매되는 것을 구입할 수 있으나, 이에 제한되지 않는다.Somi-cho (小米草) of the present invention is a plant belonging to the genus Euphrasia of the family Orobanchaceae, specifically, Euphrasia pectinata , Euphrasia officinalis , Or Euphrasia regelii ( Euphrasia regelii ) It may be, but is not limited thereto. Somi vinegar of the present invention may be harvested from nature or purchased commercially, but is not limited thereto.
본 발명에서는 소미초 추출물을 인간 모유두세포에 처리한 결과, 모유두세포의 증식 촉진 효과를 확인하였으며, 그 효과는 탈모치료제로 시판되는 미녹시딜과 유사하거나 더 우수한 것을 확인한 바 (실시예 2), 소미초 추출물을 탈모 개선 또는 발모 촉진 용도로 사용할 수 있음을 최초로 규명하였다.In the present invention, as a result of processing the somicho extract on human dermal papilla cells, the effect of promoting the proliferation of dermal papilla cells was confirmed, and the effect was confirmed to be similar to or superior to minoxidil marketed as a hair loss treatment agent (Example 2), somicho It was identified for the first time that the extract can be used for improving hair loss or promoting hair growth.
본 발명의 소미초 추출물은 하나 이상의 용매로 추출하여 수득한 추출물의 형태를 의미하는 것으로, 상기 추출물의 제조에 사용되는 용매로는 물, 탄소수 1(C1) 내지 탄소수 6(C6) 알코올, 바람직하게는 에탄올, 메탄올 또는 부탄올, 유기 용매, 또는 이들의 혼합 용매를 사용할 수 있으나, 이에 제한되지 않는다. 추출 방법으로는 용매 추출, 열수 추출, 냉침 추출, 환류 냉각 추출, 초음파 추출, 또는 증기 추출 등의 방법을 사용할 수 있으나, 이에 제한되지 않는다.The Somicho extract of the present invention refers to the form of the extract obtained by extraction with one or more solvents, and the solvent used for the preparation of the extract includes water, carbon number 1 (C 1 ) to carbon number 6 (C 6 ) alcohol, Preferably, ethanol, methanol or butanol, an organic solvent, or a mixed solvent thereof may be used, but is not limited thereto. As the extraction method, methods such as solvent extraction, hot water extraction, cold extraction, reflux cooling extraction, ultrasonic extraction, or steam extraction may be used, but are not limited thereto.
본 발명의 소미초 추출물은 에탄올로 추출한 것일 수 있으며, 예를 들어 60 내지 80% 에탄올로 추출한 것일 수 있다. 본 발명의 구체적인 일 구현예에서는 70% 에탄올을 이용하여 환류 추출하였으나, 이에 제한되지 않는다.The Somicho extract of the present invention may be extracted with ethanol, for example, may be extracted with 60 to 80% ethanol. In a specific embodiment of the present invention, reflux extraction was performed using 70% ethanol, but the present invention is not limited thereto.
본 발명의 "탈모 개선"은 탈모 상태를 치료, 경감, 완화시키는 과정 또는 그의 효과 등을 포괄적으로 의미하며, 탈모의 진행을 억제하는 모든 작용을 의미할 수 있다. 본 발명의 "발모 촉진"은 모낭에서 모발이 자라나는 것을 증가시키는 모든 행위를 의미하며, 모발의 총량을 증가시키는 모든 작용을 의미할 수 있다. 상기 탈모 개선 또는 발모 촉진은 모유두세포의 활성 촉진, 증식 촉진, 또는 사멸 억제에 의해 달성되는 것일 수 있다."Improving hair loss" of the present invention refers to a process of treating, alleviating, alleviating a hair loss condition, or its effect, and the like, and may mean any action that inhibits the progress of hair loss. "Promoting hair growth" of the present invention means any action that increases hair growth from the hair follicle, and may mean any action that increases the total amount of hair. The hair loss improvement or hair growth promotion may be achieved by promoting the activity of dermal papilla cells, promoting proliferation, or inhibiting apoptosis.
모발을 만들어내는 신체 내의 생리학적 기관인 모낭(hair follicle)은 모발의 생성 및 생성된 모발이 활발히 성장하는 성장기(anagen phase), 모발이 퇴화하는 퇴행기(catagen phase), 모발 탈락 때까지 유지되는 휴지기(telogen phase), 탈모가 일어나는 탈모기(exogen phase)로 나뉘는 모발성장 주기(hair cycle)를 반복하면서 모발의 성장과 유지 및 탈락에 관여한다. 많은 연구에 의해 이 모낭의 활성은 모유두세포에 의해 일어나며, 특히 모유두세포의 증식 및 분화가 모발성장 주기의 진행과 모발 형성에 일차적으로 관여하는 것이 알려져 있다. 모발이 활발히 성장하는 성장기에는 모유두세포의 증식 및 분화가 활발하게 일어나며, 모발의 성장이 중단되며 탈모 현상이 일어나는 퇴행기, 휴지기, 및 탈모기에는 모유두세포가 사멸된다. 따라서, 발모 및 탈모에는 모유두세포의 증식 및 사멸이 밀접하게 연관되어 있으므로, 모유두세포의 증식을 유도함으로써 성장기를 길게 하거나 혹은 세포 사멸을 억제하고 퇴행기, 휴지기, 및 탈모기를 짧게 하는 것이 탈모를 개선 및 치료 방안이 될 수 있다. 또한, 모유두 부근의 세포 분열과 이동은 모발의 성장과 밀접한 관련을 갖고 있는데, 여러 사이토카인, 호르몬 등에 의해 세포가 활성화 되어 모유두로 세포가 이동하고, 모발의 성장에 영향을 주게 된다. 따라서, 모유두세포의 증식은 탈모 억제 및 발모에 있어서 매우 중요한 인자이다.Hair follicle, a physiological organ in the body that produces hair, is the anagen phase, in which the hair is generated and generated, actively growing, the catagen phase, in which the hair is degenerated, and the resting phase (hair follicle) maintained until shedding It is involved in hair growth, maintenance, and loss while repeating the hair cycle, divided into the telogen phase) and the exogen phase in which hair loss occurs. According to many studies, it is known that the activity of this hair follicle is caused by the hair papilla cells, and in particular, the proliferation and differentiation of the hair papilla cells is primarily involved in the progression of the hair growth cycle and hair formation. During the growth phase, when hair is actively growing, hair papilla cells are actively proliferated and differentiated, and dermal papilla cells are killed during the degenerative, resting, and alopecia phases where hair growth is stopped and hair loss occurs. Therefore, hair growth and hair loss are closely related to the proliferation and death of hair papilla cells. Therefore, prolonging the growth phase or inhibiting apoptosis by inducing the proliferation of dermal papilla cells and shortening the catagen phase, resting phase, and hair loss phase improves hair loss and It could be a treatment option. In addition, cell division and migration in the vicinity of nipples are closely related to hair growth. Cells are activated by various cytokines and hormones, so cells move to nipples and affect hair growth. Therefore, proliferation of dermal papilla cells is a very important factor in suppressing hair loss and hair growth.
본 발명의 소미초 추출물을 포함하는 조성물은 모유두세포의 증식력을 현저하게 증가시키는 것을 확인한 바 (실시예 2), 탈모 개선 또는 발모 촉진 용도로 활용될 수 있다.As it was confirmed that the composition comprising the Somicho extract of the present invention significantly increases the proliferative power of dermal papilla cells (Example 2), it can be used to improve hair loss or promote hair growth.
본 발명의 조성물은 식품 조성물, 화장료 조성물, 또는 사료 조성물일 수 있다. 상기 조성물은 약학적으로 허용 가능한 담체를 추가로 포함할 수 있으며, 담체와 함께 제제화되어 식품, 화장품 및 사료로 제공될 수 있다.The composition of the present invention may be a food composition, a cosmetic composition, or a feed composition. The composition may further include a pharmaceutically acceptable carrier, and may be formulated with a carrier and provided as food, cosmetics and feed.
본 발명의 “식품”은 육류, 소시지, 빵, 초콜릿, 캔디류, 스낵류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알코올음료, 비타민 복합체, 건강기능식품 등의 통상적인 의미의 식품을 모두 포함하며, 본 발명의 소미초 추출물을 포함할 수 있는 한, 이에 제한되지 않는다. 또한 본 발명의 소미초 추출물을 즙, 차, 젤리 및 주스 등에 첨가하여 제조할 수 있으며, 본 발명의 식품 조성물은 분말, 과립, 정제, 캡슐, 환제, 또는 액제의 형태로 제조될 수 있으나, 이에 제한되지 않는다.The “food” of the present invention includes meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gum, and dairy products including ice cream, various soups, beverages, tea, drinks, alcoholic beverages, vitamins It includes all foods in the usual sense, such as complexes and health functional foods, and is not limited thereto as long as it can contain the Somicho extract of the present invention. In addition, it can be prepared by adding the Somicho extract of the present invention to juice, tea, jelly and juice, etc., and the food composition of the present invention can be prepared in the form of powder, granule, tablet, capsule, pill, or liquid, but this not limited
상기 식품 조성물의 제조 시에는 당업계에서 통상적으로 첨가하는 원료 및 성분을 첨가하여 제조할 수 있으며, 그 종류는 특별히 제한되지 않는다. 예를 들어, 통상의 식품과 같이 여러 생약 추출물, 식품학적으로 허용 가능한 식품보조첨가제 또는 천연 탄수화물 등을 추가 성분으로 포함할 수 있으며, 이에 제한되지 않는다.When the food composition is prepared, it can be prepared by adding raw materials and components commonly added in the art, and the type is not particularly limited. For example, it may include, as an additional ingredient, various herbal extracts, food-logically acceptable food supplements or natural carbohydrates, such as conventional food, but is not limited thereto.
본 발명의 식품 조성물이 건강기능식품 조성물일 경우, "건강기능식품"은 건강기능식품에 관한 법률 제6727호에 따른 인체에 유용한 기능성을 가진 원료나 성분을 사용하여 제조 및 가공한 식품을 의미하며, '기능성'은 인체의 구조 및 기능에 대하여 영양소를 조절하거나 생리학적 작용 등과 같은 보건 용도에 유용한 효과를 얻는 것을 의미한다. 한편, 건강식품은 일반식품에 비해 적극적인 건강유지나 증진 효과를 가지는 식품을 의미하고, 건강보조식품은 건강 보조 목적의 식품을 의미하는데, 경우에 따라, 건강기능식품, 건강식품, 건강보조식품의 용어는 혼용될 수 있다.When the food composition of the present invention is a health functional food composition, "health functional food" means a food manufactured and processed using raw materials or ingredients useful for the human body according to the Health Functional Food Act No. 6727, , 'functionality' refers to obtaining useful effects for health purposes such as regulating nutrients or physiological effects on the structure and function of the human body. On the other hand, health food means food that has an active health maintenance or promotion effect compared to general food, and health supplement means food for the purpose of health supplementation. In some cases, the terms health functional food, health food and health supplement food can be mixed.
본 발명의 식품 조성물은 그대로 첨가되거나 다른 식품 또는 식품 성분과 함께 사용될 수 있고, 통상적인 방법에 따라 적절하게 사용될 수 있다.The food composition of the present invention may be added as it is or used together with other foods or food ingredients, and may be appropriately used according to a conventional method.
본 발명의 건강기능식품 조성물은 당업계에서 통상적으로 사용되는 방법에 의하여 제조 가능하며, 상기 제조 시에는 당업계에서 통상적으로 첨가하는 원료 및 성분을 첨가하여 제조할 수 있다. 구체적으로, 상기 건강기능식품 조성물은 생리학적으로 허용가능한 담체를 추가로 포함할 수 있는데, 담체의 종류는 특별히 제한되지 않으며 당해 기술 분야에서 통상적으로 사용되는 담체라면 어느 것이든 사용할 수 있다.The health functional food composition of the present invention can be prepared by a method commonly used in the art, and at the time of manufacture, it can be prepared by adding raw materials and components commonly added in the art. Specifically, the health functional food composition may further include a physiologically acceptable carrier, the type of carrier is not particularly limited and any carrier commonly used in the art may be used.
또한, 상기 건강기능식품 조성물은 방부제, 살균제, 산화방지제, 착색제, 발색제, 표백제, 조미료, 감미료, 향료, 팽창제, 강화제, 유화제, 증점제, 피막제, 검기초제, 거품억제제, 용제, 개량제 등의 식품 첨가물을 포함할 수 있다. 상기 첨가물은 식품의 종류에 따라 선별되고 적절한 양으로 사용될 수 있다. 또한, 상기 건강기능식품의 제형은 식품으로 인정되는 제형이면 제한 없이 제조될 수 있다.In addition, the health functional food composition is a food such as a preservative, a disinfectant, an antioxidant, a colorant, a coloring agent, a bleaching agent, a seasoning, a sweetener, a flavoring, an expanding agent, a strengthening agent, an emulsifier, a thickener, a film agent, a gum base agent, a foam inhibitor, a solvent, an improving agent, etc. It may contain additives. The additive may be selected according to the type of food and used in an appropriate amount. In addition, the formulation of the health functional food may be manufactured without limitation as long as it is a formulation recognized as a food.
본 발명의 용어 "화장료 조성물"은 용액, 외용연고, 크림, 폼, 영양화장수, 유연화장수, 팩, 유연수, 유액, 메이크업베이스, 에센스, 비누, 액체 세정료, 입욕제, 선 스크린크림, 선오일, 현탁액, 유탁액, 페이스트, 겔, 로션, 파우더, 비누, 계면활성제-함유 클린싱, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션, 패취 및 스프레이로 구성된 군으로부터 선택되는 제형으로 제조할 수 있으며, 구체적으로는 피부 외용제의 형태로 제조될 수 있으나, 이에 제한되지 않는다.As used herein, the term "cosmetic composition" refers to solutions, external ointments, creams, foams, nourishing lotions, softening lotions, packs, softening water, emulsions, makeup bases, essences, soaps, liquid detergents, bathing agents, sunscreen creams, sun oils, Suspension, emulsion, paste, gel, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, patch and spray, specifically As such, it may be prepared in the form of an external preparation for skin, but is not limited thereto.
본 발명에서 상기 피부 외용제는 헤어토닉, 헤어크림, 헤어로션, 헤어샴푸, 헤어린스, 헤어컨디셔너, 헤어스프레이, 헤어에어졸, 포마드, 분말, 젤, 헤어팩, 헤어트리트먼트, 눈썹발모제, 속눈썹 발모제, 및 속눈썹 영양제로 이루어진 군에서 선택된 것일 수 있으나, 이에 제한되지 않는다.In the present invention, the external preparation for skin includes hair tonic, hair cream, hair lotion, hair shampoo, hair conditioner, hair conditioner, hair spray, hair aerosol, pomade, powder, gel, hair pack, hair treatment, eyebrow hair growth agent, eyelash hair growth agent, and It may be selected from the group consisting of eyelash nutrients, but is not limited thereto.
또한, 본 발명의 화장료 조성물은 일반 피부 화장료에 배합되는 화장품학적으로 허용 가능한 담체를 1종 이상 추가로 포함할 수 있으며, 통상의 성분으로 예를 들면 유분, 물, 계면활성제, 보습제, 저급 알콜, 증점제, 킬레이트제, 색소, 방부제, 향료 등을 적절히 배합할 수 있으나, 이에 제한되지 않는다. 본 발명의 화장료 조성물에 포함되는 화장품학적으로 허용 가능한 담체는 제형에 따라 다양하다.In addition, the cosmetic composition of the present invention may further include one or more cosmetically acceptable carriers to be formulated in general skin cosmetics, and conventional ingredients include, for example, oil, water, surfactant, humectant, lower alcohol, A thickener, a chelating agent, a colorant, a preservative, a fragrance, etc. may be appropriately mixed, but is not limited thereto. The cosmetically acceptable carrier included in the cosmetic composition of the present invention varies depending on the formulation.
또한, 본 발명의 화장료 조성물은 소미초 추출물 이외에 통상적으로 이용되는 보조제, 예컨대 친수성 또는 친지성 겔화제, 친수성 또는 친지성 활성제, 보존제, 항산화제, 용매, 방향제, 충전제, 차단제, 안료, 흡취제 및 염료 등을 포함할 수 있다. 본 발명의 화장료 조성물에 포함되는 유효성분의 혼합량은 사용 목적에 따라 적합하게 결정될 수 있다.In addition, the cosmetic composition of the present invention includes, in addition to the Somicho extract, commonly used auxiliary agents, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preservatives, antioxidants, solvents, fragrances, fillers, blocking agents, pigments, odorants, and dyes and the like. The mixing amount of the active ingredient included in the cosmetic composition of the present invention may be suitably determined according to the purpose of use.
본 발명의 용어 "사료"는 동물이 먹고, 섭취하며, 소화시키기 위한 또는 이에 적당한 임의의 천연 또는 인공 규정식, 한끼식 등 또는 상기 한끼식의 성분으로, 본 발명의 소미초 추출물을 포함하는 사료는 당업계의 공지된 다양한 형태의 사료로 제조 가능하며, 구체적으로는 농후사료, 조사료 또는 특수사료가 포함될 수 있다. 사육 대상은 본 발명의 사료를 섭취할 수 있는 생명체라면 제한 없이 포함될 수 있다. The term "feed" of the present invention refers to any natural or artificial diet, one meal, etc. or a component of the one meal meal suitable for or suitable for eating, ingestion, and digestion by animals, a feed containing the extract of the present invention. can be prepared in various types of feed known in the art, specifically, it may include a concentrated feed, roughage or special feed. The breeding target may be included without limitation as long as it is an organism capable of ingesting the feed of the present invention.
본 발명의 사료 조성물은 투여를 위해서 추가로 구연산, 푸마르산, 아디프산, 젖산 등의 유기산; 인산칼륨, 인산나트륨, 중합 인산염 등의 인산염; 폴리페놀, 카테친, 토코페롤, 비타민 C, 녹차 추출물, 키토산, 탄니산 등의 천연 항산화제 중 1종 이상을 혼합하여 사용할 수 있으며, 필요에 따라 항인플루엔자제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한 희석제, 분산제, 계면활성제, 결합제 또는 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주사용 제형, 캡슐, 과립 또는 정제로 제제화할 수 있다.The feed composition of the present invention may further include organic acids such as citric acid, fumaric acid, adipic acid, and lactic acid for administration; phosphates such as potassium phosphate, sodium phosphate, and polymerized phosphate; One or more of natural antioxidants such as polyphenol, catechin, tocopherol, vitamin C, green tea extract, chitosan, and tannic acid can be mixed and used. can do. In addition, diluents, dispersants, surfactants, binders or lubricants may be additionally added to form an injectable formulation such as an aqueous solution, suspension, emulsion, etc., capsules, granules or tablets.
또한, 본 발명의 사료 조성물은 보조성분으로 아미노산, 무기염류, 비타민, 항산화제, 항진균제, 항균제 등과 같은 각종 보조제 및 분쇄 또는 파쇄된 밀, 보리, 옥수수 등의 식물성 단백질 사료, 혈분, 육분, 생선분 등의 동물성 단백질 사료, 동물성 지방 및 식물성 지방 같은 주성분 이외에도 영양 보충제, 성장 촉진제, 소화 흡수 촉진제, 질병 예방제와 함께 사용될 수 있다.In addition, the feed composition of the present invention includes various auxiliary agents such as amino acids, inorganic salts, vitamins, antioxidants, antifungals, and antibacterial agents as auxiliary components, and plant protein feed such as milled or crushed wheat, barley, and corn, blood meal, meat meal, fish meal, etc. In addition to the main ingredients such as animal protein feed, animal fat and vegetable fat, it can be used together with nutritional supplements, growth promoters, digestion and absorption promoters, and disease prevention agents.
본 발명의 소미초 추출물을 유효성분으로 포함하는 사료 조성물은 사육 대상의 탈모 개선 또는 발모 촉진 용도로 사용될 수 있다.The feed composition comprising the Somicho extract of the present invention as an active ingredient can be used to improve hair loss or promote hair growth in breeding subjects.
본 발명의 다른 하나의 양태는 소미초 추출물을 유효성분으로 포함하는 탈모 질환의 예방 또는 치료용 약학 조성물을 제공한다.Another aspect of the present invention provides a pharmaceutical composition for preventing or treating hair loss disease comprising a Somicho extract as an active ingredient.
본 발명의 "소미초 추출물"은 상기 기재된 바와 같다."Somicho extract" of the present invention is as described above.
본 발명의 탈모는, 정상적으로 모발이 존재해야 할 부위에 모발이 없는 상태를 의미하며, 구체적으로는 두피의 성모(굵고 검은 머리털)이 빠지는 것을 의미할 수 있다. 탈모의 원인은 제한되지 않으나, 유전적인 원인, 호르몬 불균형, 정신적 스트레스, 대기오염 노출, 가공 식품의 섭취 등의 다양한 식습관 및 환경적 영향으로 인하여 유발될 수 있다. 예를 들어, 상기 탈모는 유전성 안드로겐성 탈모(대머리), 원형 탈모, 곰팡이 감염에 의한 두부 백선, 휴지기 탈모, 발모벽, 모발생성 장애 질환 등이 있고, 흉터가 형성되는 반흔성 탈모로는 루푸스에 의한 탈모, 독발성 모낭염, 모공성 편평 태선, 화상 및 외상에 의한 탈모를 의미할 수 있다.The hair loss of the present invention means a state in which there is no hair in a part where hair should normally exist, and specifically, it may mean that the hair (thick and dark hair) of the scalp falls out. The cause of hair loss is not limited, but may be caused by various dietary and environmental influences such as genetic causes, hormonal imbalance, mental stress, exposure to air pollution, and intake of processed foods. For example, the hair loss includes hereditary androgenetic alopecia (baldness), circular alopecia, ringworm of the head due to fungal infection, telogen alopecia, hair growth wall, hair growth disorder diseases, etc. It can mean hair loss due to alopecia, solitary folliculitis, lichen planus pilaris, burns and trauma hair loss.
본 발명의 용어 "치료"는 치료하고자 하는 개개인 또는 세포의 천연 과정을 변경시키기 위해 임상적으로 개입하는 것을 지칭하고, 이는 임상 병리 상태가 진행되는 동안 또는 이를 예방하기 위해 수행할 수 있다. 목적하는 치료 효과에는 질병의 발생 또는 재발을 예방하고, 증상을 완화시키며, 질병에 따른 모든 직접 또는 간접적인 병리학적 결과를 저하시키며, 전이를 예방하고, 질병 진행 속도를 감소시키며, 질병 상태를 경감 또는 일시적 완화시키며, 차도시키거나 예후를 개선시키는 것이 포함된다. 본 발명에서는 소미초 추출물을 유효성분으로 포함하는 조성물의 투여로 탈모의 경과를 호전시키는 모든 행위를 포함한다. 또한, 본 발명의 용어 "예방"은 본 발명에 따른 소미초 추출물을 유효성분으로 포함하는 조성물의 투여로 상기 탈모 질환의 발병을 억제 또는 지연시키는 모든 행위를 의미한다.As used herein, the term “treatment” refers to clinical intervention to alter the natural process of an individual or cell to be treated, which may be performed during the course of or to prevent a clinical pathology. The desired therapeutic effect includes preventing the occurrence or recurrence of a disease, alleviating symptoms, reducing any direct or indirect pathological consequences of the disease, preventing metastasis, reducing the rate of disease progression, and alleviating the disease state. or temporary relief, remission or improvement of prognosis. In the present invention, it includes all acts of improving the course of hair loss by administering a composition comprising a Somicho extract as an active ingredient. In addition, the term "prevention" of the present invention means any action that inhibits or delays the onset of the hair loss disease by administration of a composition comprising the Somicho extract according to the present invention as an active ingredient.
본 발명의 약학 조성물은 모유두세포의 증식력을 증가시킴으로써 탈모 질환의 예방 또는 치료 효과를 나타내는 것일 수 있다.The pharmaceutical composition of the present invention may exhibit a preventive or therapeutic effect for hair loss disease by increasing the proliferative power of dermal papilla cells.
본 발명의 용어 "약학 조성물"은 약학 조성물의 제조에 통상적으로 사용하는 적절한 담체, 부형제 또는 희석제를 추가로 포함할 수 있다. 약학적으로 허용 가능한 담체를 포함하는 조성물은 경구 또는 비경구의 여러 가지 제형일 수 있다. 제제화할 경우에는 보통 사용하는 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제될 수 있다. 경구 투여를 위한 고형제제에는 정제환제, 산제, 과립제, 캡슐제 등이 포함될 수 있으며, 이러한 고형제제는 하나 이상의 화합물에 적어도 하나 이상의 부형제, 예를 들면, 전분, 탄산칼슘, 수크로오스(sucrose) 또는 락토오스(lactose), 젤라틴 등을 섞어 조제될 수 있다. 또한, 단순한 부형제 이외에 스테아린산 마그네슘, 탈크 등과 같은 윤활제들도 사용될 수 있다. 경구 투여를 위한 액상제제로는 현탁제, 내용액제, 유제, 시럽제 등이 해당되는데 흔히 사용되는 단순 희석제인 물, 리퀴드 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제, 보존제 등이 포함될 수 있다. 비경구투여를 위한 제제에는 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결건조제제, 좌제가 포함될 수 있다. 비수성용제, 현탁용제로는 프로필렌글리콜 (propylene glycol), 폴리에틸렌 글리콜, 올리브 오일과 같은 식물성 기름, 에틸올레이트와 같은 주사 가능한 에스테로 등이 사용될 수 있다. 좌제의 기제로는 위텝솔(witepsol), 마크로골, 트윈(tween) 61, 카카오지, 라우린지, 글리세로젤라틴 등이 사용될 수 있다.The term "pharmaceutical composition" of the present invention may further include an appropriate carrier, excipient or diluent commonly used in the preparation of pharmaceutical compositions. The composition comprising a pharmaceutically acceptable carrier may be in various oral or parenteral dosage forms. In the case of formulation, it can be prepared using a diluent or excipient such as a filler, extender, binder, wetting agent, disintegrant, surfactant, etc. commonly used. Solid preparations for oral administration may include tablet pills, powders, granules, capsules, etc., and these solid preparations include at least one excipient in one or more compounds, for example, starch, calcium carbonate, sucrose or lactose. It can be prepared by mixing (lactose), gelatin, etc. In addition to simple excipients, lubricants such as magnesium stearate, talc and the like may also be used. Liquid preparations for oral administration include suspensions, internal solutions, emulsions, syrups, etc. In addition to commonly used simple diluents such as water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included. have. Formulations for parenteral administration may include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, lyophilized formulations, and suppositories. Non-aqueous solvents and suspensions may include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, and the like can be used.
또한, 본 발명의 약학 조성물은 이에 제한되지 않으나, 정제, 환제, 산제, 과립제, 캡슐제, 현탁제, 내용액제, 유제, 시럽제, 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결건조제제 및 좌제로 이루어진 군으로부터 선택되는 어느 하나의 제형을 가질 수 있다.In addition, the pharmaceutical composition of the present invention is not limited thereto, but tablets, pills, powders, granules, capsules, suspensions, internal solutions, emulsions, syrups, sterilized aqueous solutions, non-aqueous solvents, suspensions, emulsions, freeze-dried preparations and It may have any one formulation selected from the group consisting of suppositories.
본 발명의 또 다른 하나의 양태는 소미초 추출물을 유효성분으로 포함하는 조성물을 개체에 투여하는 단계를 포함하는 탈모 질환의 예방 또는 치료방법을 제공한다.Another aspect of the present invention provides a method for preventing or treating hair loss disease comprising administering to an individual a composition comprising a Somicho extract as an active ingredient.
본 발명에서 사용되는 용어, "개체"란, 탈모 상태가 되었거나 될 가능성이 있는 인간을 포함한 모든 동물을 의미할 수 있다. 상기 동물은 인간뿐만 아니라 이와 유사한 증상의 치료를 필요로 하는 소, 말, 양, 돼지, 염소, 낙타, 영양, 개, 고양이 등의 포유동물일 수 있으나, 이에 제한되지는 않는다.As used herein, the term "individual" may refer to all animals, including humans, who have or are likely to become bald. The animal may be a mammal, such as a cow, a horse, a sheep, a pig, a goat, a camel, an antelope, a dog, or a cat, in need of treatment for symptoms similar to those of a human as well as humans, but is not limited thereto.
본 발명의 상기 예방 또는 치료 방법은 구체적으로, 탈모 상태가 되었거나 될 가능성이 있는 개체에 상기 조성물을 약학적으로 유효한 양으로 투여하는 단계를 포함할 수 있다. Specifically, the prevention or treatment method of the present invention may include the step of administering the composition in a pharmaceutically effective amount to an individual who has become or is likely to become a hair loss state.
발명에서 사용된 용어, "투여"는 어떠한 적절한 방법으로 환자에게 본 발명의 약학적 조성물을 도입하는 것을 의미하며, 본 발명의 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있다.As used herein, the term "administration" means introducing the pharmaceutical composition of the present invention to a patient by any suitable method, and the administration route of the composition of the present invention may be oral or parenteral as long as it can reach the target tissue. It may be administered via a route.
본 발명의 다른 하나의 양태는 소미초 추출물을 유효성분으로 포함하는 식품 조성물의 탈모 개선 또는 발모 촉진용도를 제공한다. Another aspect of the present invention provides a use for improving hair loss or promoting hair growth of a food composition comprising a Somicho extract as an active ingredient.
본 발명의 또 다른 하나의 양태는 소미초 추출물을 유효성분으로 포함하는 화장료 조성물의 탈모 개선 또는 발모 촉진용도를 제공한다. Another aspect of the present invention provides a use for improving hair loss or promoting hair growth of a cosmetic composition comprising a Somicho extract as an active ingredient.
본 발명의 또 다른 하나의 양태는 소미초 추출물을 유효성분으로 포함하는 사료 조성물의 탈모 개선 또는 발모 촉진용도를 제공한다. Another aspect of the present invention provides a use for improving hair loss or promoting hair growth of a feed composition comprising a Somicho extract as an active ingredient.
본 발명의 또 다른 하나의 양태는 소미초 추출물을 유효성분으로 포함하는 약학 조성물의 탈모 질환의 예방 또는 치료용도를 제공한다. Another aspect of the present invention provides a use for preventing or treating hair loss disease of a pharmaceutical composition comprising a Somicho extract as an active ingredient.
이하, 실시예를 통하여 본 발명을 보다 상세히 설명하고자 한다. 이들 실시예는 본 발명을 보다 구체적으로 설명하기 위한 것으로, 본 발명의 범위가 이들 실시예에 의해 한정되는 것은 아니다.Hereinafter, the present invention will be described in more detail through examples. These Examples are for explaining the present invention in more detail, and the scope of the present invention is not limited by these Examples.
실시예 1. 소미초 추출물의 제조Example 1. Preparation of Somicho Extract
소미초(小米草)의 전초를 분쇄한 후, 상기 분쇄된 소미초 전초의 건조 중량의 10 부피배 (소미초전초 건조중량 1g 당 10mL에 해당)의 70% 에탄올을 넣고, 80℃에서 3시간 환류 추출하였다. 이를 20호 정성 거름종이로 감압여과한 후, 회전진공증발기 (Rotary vacuum evaporator) (N-1200A, EYELA, JAPAN)로 감압 농축하고, 동결건조기(OPR-FD4-8612, OPERON, KOREA)로 동결 건조하여 소미초 추출물을 제조하였다.After pulverizing the soybean sprouts, 70% ethanol of 10 times the dry weight of the pulverized soybean sprouts (corresponding to 10mL per 1g of the dry weight of the millet) was added, and 3 hours at 80°C. reflux extraction. This was filtered under reduced pressure with qualitative filter paper No. 20, concentrated under reduced pressure with a rotary vacuum evaporator (N-1200A, EYELA, JAPAN), and freeze-dried with a freeze dryer (OPR-FD4-8612, OPERON, KOREA) Somicho extract was prepared.
실시예 2. 소미초 추출물의 탈모 개선 및 발모 촉진 효과 확인Example 2. Confirmation of hair loss improvement and hair growth promoting effect of Somicho extract
실시예 1에서 제조한 소미초 추출물의 탈모 개선 및 발모 촉진 효과를 확인하기 위해, 상기 소미초의 주정 추출물을 인간 모유두세포 (HDPC: Human Dermal Papilla Cell)에 처리하여 세포 증식능을 측정하고, 기존 탈모치료제인 미녹시딜 (MX: Minoxidil)과 그 효능을 비교하였다. In order to confirm the hair loss improvement and hair growth promoting effect of the Somicho extract prepared in Example 1, the ethanol extract of Somicho was treated with human dermal papilla cells (HDPC) to measure cell proliferation, and the existing hair loss treatment agent The efficacy was compared with phosphorus minoxidil (MX: Minoxidil).
인간 모유두세포에 소미초 70% 주정 추출물 또는 미녹시딜(MX)을 각각 처리한 후, WST Assay를 통해 세포 증식능을 확인하였다. 구체적으로, 인간 모유두세포를 5% CO2 및 37℃ 조건에서 10%(v/v) FBS 및 1%(v/v) 페니실린/스트렙토마이신을 함유한 DMEM 배지를 이용하여 96-웰 플레이트에 Seeding한 후, 37℃, 5% CO2 배양기에서 24시간 동안 배양시켰다. 이후, 배지에 상기 실시예 1의 소미초의 주정 추출물을 5, 10 또는 50μg/mL의 농도로 처리하고, 미녹시딜을 5, 10μM 농도로 처리하였다. 이후, 48시간 동안 인큐베이션하고, CCK(D-PlusTM CCK cell viability assay kit) 시약 10μL를 처리한 후, 37℃, 5% CO2 습윤 조건 하에서 2시간 동안 배양하였다. 2시간 배양 후 배지를 제거하고 450 nm에서 흡광도를 측정하였다. 상기 시험은 3회 반복하였다.Human dermal papilla cells were treated with 70% somicholic alcohol extract or minoxidil (MX), respectively, and cell proliferation ability was confirmed through WST Assay. Specifically, human dermal papilla cells were seeded in a 96-well plate using DMEM medium containing 10% (v/v) FBS and 1% (v/v) penicillin/streptomycin under 5% CO 2 and 37° C. conditions. After that, 37 ℃, 5% CO 2 Incubated in an incubator for 24 hours. Then, the medium was treated with the alcohol extract of Somicho of Example 1 at a concentration of 5, 10, or 50 μg/mL, and minoxidil was treated with a concentration of 5 and 10 μM. Then, incubated for 48 hours, treated with 10 μL of CCK (D-Plus TM CCK cell viability assay kit) reagent, and incubated for 2 hours at 37° C., 5% CO 2 wet condition. After incubation for 2 hours, the medium was removed and absorbance was measured at 450 nm. The test was repeated 3 times.
그 결과, 도 1에 나타난 바와 같이, 본 발명의 소미초 추출물 처리 시, 농도 의존적으로 모유두세포 증식력을 증가시켰다. 특히, 기존 탈모치료제인 미녹시딜과 비교하면, 미녹시딜(MX)과 유사하거나 더 우수한 정도로 모유두세포의 증식력을 증가시키는 것을 확인하였다. As a result, as shown in FIG. 1, when the Somicho extract of the present invention was treated, the dermal papilla cell proliferation was increased in a concentration-dependent manner. In particular, compared with minoxidil, which is an existing hair loss treatment, it was confirmed that it increased the proliferative power of dermal papilla cells to a degree similar to or superior to minoxidil (MX).
이상의 설명으로부터, 본 발명이 속하는 기술분야의 당업자는 본 발명이 그 기술적 사상이나 필수적 특징을 변경하지 않고서 다른 구체적인 형태로 실시될 수 있다는 것을 이해할 수 있을 것이다. 이와 관련하여, 이상에서 기술한 실시예들은 모든 면에서 예시적인 것이며 한정적인 것이 아닌 것으로 이해해야만 한다. 본 발명의 범위는 상기 상세한 설명보다는 후술하는 청구범위의 의미 및 범위 그리고 그 등가 개념으로부터 도출되는 모든 변경 또는 변형된 형태가 본 발명의 범위에 포함되는 것으로 해석되어야 한다.From the above description, those skilled in the art to which the present invention pertains will understand that the present invention may be embodied in other specific forms without changing the technical spirit or essential characteristics thereof. In this regard, it should be understood that the embodiments described above are illustrative in all respects and not restrictive. The scope of the present invention should be construed as being included in the scope of the present invention, rather than the above detailed description, all changes or modifications derived from the meaning and scope of the claims described below and their equivalents.
Claims (14)
- 소미초 추출물을 유효성분으로 포함하는 탈모 개선 또는 발모 촉진용 식품 조성물.A food composition for improving hair loss or promoting hair growth, comprising a Somicho extract as an active ingredient.
- 제1항에 있어서, 상기 추출물은 물, 탄소수 1 내지 6의 알코올, 유기 용매, 또는 이들의 혼합 용매로 추출하여 제조되는 것인, 식품 조성물.The food composition according to claim 1, wherein the extract is prepared by extraction with water, an alcohol having 1 to 6 carbon atoms, an organic solvent, or a mixed solvent thereof.
- 제1항에 있어서, 상기 탈모 개선 또는 발모 촉진은 모유두세포의 활성 촉진, 증식 촉진, 또는 사멸 억제에 의해 달성되는 것인, 식품 조성물.The food composition of claim 1, wherein the improvement of hair loss or promotion of hair growth is achieved by promoting the activity of dermal papilla cells, promoting proliferation, or inhibiting apoptosis.
- 제1항에 있어서, 상기 식품 조성물은 분말, 과립, 정제, 캡슐, 환제, 또는 액제의 형태로 제조되는 것인, 식품 조성물.The food composition according to claim 1, wherein the food composition is prepared in the form of a powder, granules, tablets, capsules, pills, or liquids.
- 소미초 추출물을 유효성분으로 포함하는 탈모 개선 또는 발모 촉진용 화장료 조성물.A cosmetic composition for improving hair loss or promoting hair growth, comprising Somicho extract as an active ingredient.
- 제5항에 있어서, 상기 화장료 조성물은 피부 외용제의 형태로 제조되는 것인, 화장료 조성물.The cosmetic composition according to claim 5, wherein the cosmetic composition is prepared in the form of an external preparation for skin.
- 제6항에 있어서, 상기 피부 외용제는 헤어토닉, 헤어크림, 헤어로션, 헤어샴푸, 헤어린스, 헤어컨디셔너, 헤어스프레이, 헤어에어졸, 포마드, 분말, 젤, 헤어팩, 헤어트리트먼트, 눈썹발모제, 속눈썹 발모제, 및 속눈썹 영양제로 이루어진 군에서 선택된 하나 이상인 것인, 화장료 조성물.The method of claim 6, wherein the external preparation for skin is hair tonic, hair cream, hair lotion, hair shampoo, hair conditioner, hair conditioner, hair spray, hair aerosol, pomade, powder, gel, hair pack, hair treatment, eyebrow hair growth agent, eyelashes A cosmetic composition that is at least one selected from the group consisting of a hair restorer and an eyelash nutrient.
- 소미초 추출물을 유효성분으로 포함하는 탈모 개선 또는 발모 촉진용 사료 조성물.A feed composition for improving hair loss or promoting hair growth comprising a somicho extract as an active ingredient.
- 소미초 추출물을 유효성분으로 포함하는 탈모 질환의 예방 또는 치료용 약학 조성물.A pharmaceutical composition for the prevention or treatment of hair loss disease comprising a Somicho extract as an active ingredient.
- 소미초 추출물을 유효성분으로 포함하는 조성물을 개체에 투여하는 단계를 포함하는 탈모 질환의 예방 또는 치료방법.A method for preventing or treating hair loss disease, comprising administering to an individual a composition comprising Somicho extract as an active ingredient.
- 소미초 추출물을 유효성분으로 포함하는 식품 조성물의 탈모 개선 또는 발모 촉진용도.Use of improving hair loss or promoting hair growth of a food composition comprising Somicho extract as an active ingredient.
- 소미초 추출물을 유효성분으로 포함하는 화장료 조성물의 탈모 개선 또는 발모 촉진용도.Use of improving hair loss or promoting hair growth of a cosmetic composition comprising Somicho extract as an active ingredient.
- 소미초 추출물을 유효성분으로 포함하는 사료 조성물의 탈모 개선 또는 발모 촉진용도.Use of improving hair loss or promoting hair growth of a feed composition comprising Somicho extract as an active ingredient.
- 소미초 추출물을 유효성분으로 포함하는 약학 조성물의 탈모 질환의 예방 또는 치료용도.Prevention or treatment of hair loss diseases of a pharmaceutical composition comprising a Somicho extract as an active ingredient.
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| KR1020200183033A KR20220091869A (en) | 2020-12-24 | 2020-12-24 | Composition for improving hair loss and promoting hair growth containing Euphrasiae herba |
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| KR101208736B1 (en) * | 2010-10-15 | 2012-12-06 | 애경산업(주) | The hair growth compositions containing flavonoids |
| CN106726818A (en) * | 2015-11-20 | 2017-05-31 | 周丽 | A kind of Hair-loss-preventingshampoo shampoo |
| WO2018207952A1 (en) * | 2017-05-12 | 2018-11-15 | 国立大学法人九州大学 | Composition for hair growth and/or hair restoration |
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| KR101208736B1 (en) * | 2010-10-15 | 2012-12-06 | 애경산업(주) | The hair growth compositions containing flavonoids |
| CN106726818A (en) * | 2015-11-20 | 2017-05-31 | 周丽 | A kind of Hair-loss-preventingshampoo shampoo |
| WO2018207952A1 (en) * | 2017-05-12 | 2018-11-15 | 国立大学法人九州大学 | Composition for hair growth and/or hair restoration |
Non-Patent Citations (2)
| Title |
|---|
| ANONYMOUS: "Assessment report on Euphrasia officinalis L. and Euphrasia rostkoviana Hayne, herba", EUROPEAN MEDICINES AGENCY, 16 September 2010 (2010-09-16), XP055945992, Retrieved from the Internet <URL:https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-euphrasia-officinalis-l-euphrasia-rostkoviana-hayne-herba_en.pdf> * |
| MCCULLOCH, M.: "Do Eyebright Drops and Supplements Benefit Health?", HEALTHLINE WEBSITE, pages 1 - 15, XP009537821, Retrieved from the Internet <URL:https://www.healthline.com/nutrition/eyebright> * |
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