WO2022124918A1 - Tube - Google Patents

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Publication number
WO2022124918A1
WO2022124918A1 PCT/PL2021/000091 PL2021000091W WO2022124918A1 WO 2022124918 A1 WO2022124918 A1 WO 2022124918A1 PL 2021000091 W PL2021000091 W PL 2021000091W WO 2022124918 A1 WO2022124918 A1 WO 2022124918A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube
stopper
neck
stabilizers
thread
Prior art date
Application number
PCT/PL2021/000091
Other languages
French (fr)
Inventor
Konrad Wilandt
Norbert Wilandt
Artur WILANDT
Original Assignee
Biovico Sp. Z O. O.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovico Sp. Z O. O. filed Critical Biovico Sp. Z O. O.
Priority to EP21859344.0A priority Critical patent/EP4259331A1/en
Publication of WO2022124918A1 publication Critical patent/WO2022124918A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/029—Separating blood components present in distinct layers in a container, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0415—Plasma
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0835—Ampoules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls

Definitions

  • the subject of the utility model is a tube for the separation of biological material.
  • tubes with a cylindrical shape and a rounded bottom were used to obtain platelet-rich plasma, where plasma separated from blood was obtained as a result of centrifugation.
  • a closed system for obtaining high-platelet plasma is also known.
  • This system consists of a single ampoule with a central constriction, resembling the shape of an hourglass, and each of the ends has a protective stopper (DrPRP system).
  • Another well-known plasma platelet concentration system is the GPS® Platelet Concentration System, which contains a cylindrical vessel, enclosed flat from above. In the top cover there are three entrances closed with caps.
  • the tube according to this formula enables the separation and isolation of highly concentrated, autologous platelet rich plasma (PRP) or injectable platelet rich fibrin (iPRF), dedicated to applications in orthopedics, dentistry, gynecology, regenerative medicine and aesthetic medicine.
  • PRP platelet rich plasma
  • iPRF injectable platelet rich fibrin
  • This utility model is a tube which, through its shape, ensures proper centrifugation and obtaining blood products with a high concentration of platelets in the blood plasma.
  • the object of the utility model is a centrifuge tube, which in the upper part of the round body is in a shape which narrows upwards in the form of a neck on the circumference of which there are four stabilizers: in the lower part the tube body there is a thread.
  • Tube the stabilizers of which are in the shape of rings.
  • Tube which has a cap with a closure at the end of the neck.
  • Tube where the thread of the tube body has a round nut. Tube, where the round nut has the base of the tube cap and the tube stopper with spin- formed sides.
  • Fig. 1 - shows the tube in front view with a scale
  • Fig. 2 - shows the tube in the rear view with a scale.
  • Fig- 3 - shows A) the base of the tube stopper (indication 8), B) the tube stopper (indication 7), C) the round nut of the lower part of the tube body in top and side view (indication 5);
  • Fig. 4 - shows an unfolded tube.
  • Fig. 5 - shows the tube in its entirety (folded).
  • Fig. 6 - shows the tube in its entirety (folded) in the top view.
  • Fig. 7 - shows the tube in its entirety (folded) in the view from below.
  • Fig. 8 - shows the tube in its entirety (folded) in a top view.
  • Tube which is the subject of the utility model, is shown in Figures 1 -8, which shows its structure in the front view.
  • Tube according to the formula has a cylindrical shape (round body (3)) tapering upwards to form a neck (2), on the circumference of which there are four stabilizers (1) in the form of rings; in the lower part, the body of the tube (3) there is a thread (4), on which a round nut is applied (5).
  • the elements of the tube are the tube stopper (7), the base of the tube cap (8) and the tube nut (5).
  • the tube stopper (7) is pressed from the bottom to the centre of the tube (3).
  • the base of the tube stopper (8) is placed by pressing.
  • a round nut (5) is wound on the thread (4), thereby closing the tube (3) from the bottom.
  • a plug with a closure (6) At the end of the neck (2) there is a plug with a closure (6).
  • the construction of the tube made of a special polymer - polycarbonate is characterized by low surface bonding energy.
  • the usage of specially selected raw materials in the production means that the tube does not bind cytokines and growth factors during the procedure for the preparation of blood-derived autologous products and does not affect their final concentration in the finally prepared product ready for injection.
  • the tube has been enriched with additional stabilizers (1) in its upper part.
  • stabilizers (1) in the form of regular rings around the neck (2) of the tube (3), allow for better distribution of the tube mass during the centrifugation process, which significantly improves the efficiency of blood separation into fractions.
  • the scale placed directly on the neck of the tube (2) it is possible to collect from the tube very accurately (3) separated fractions of autologous preparations, characterized by a high concentration of blood morphotic elements.
  • 1 - means ring-shaped stabilizers

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Centrifugal Separators (AREA)
  • Closures For Containers (AREA)

Abstract

The object of the utility model is a centrifuge tube, which in the upper part of the round body (3) is in a shape which narrows upwards in the form of a neck (2) on the circumference of which there are four stabilizers (1); in the lower part the tube body (3) there is a thread (4).

Description

Tube
The subject of the utility model is a tube for the separation of biological material.
Until now, tubes with a cylindrical shape and a rounded bottom were used to obtain platelet-rich plasma, where plasma separated from blood was obtained as a result of centrifugation.
At the present moment, a closed system for obtaining high-platelet plasma is also known. This system consists of a single ampoule with a central constriction, resembling the shape of an hourglass, and each of the ends has a protective stopper (DrPRP system).
Another well-known plasma platelet concentration system is the GPS® Platelet Concentration System, which contains a cylindrical vessel, enclosed flat from above. In the top cover there are three entrances closed with caps.
The tube according to this formula enables the separation and isolation of highly concentrated, autologous platelet rich plasma (PRP) or injectable platelet rich fibrin (iPRF), dedicated to applications in orthopedics, dentistry, gynecology, regenerative medicine and aesthetic medicine. The tube enables quick and safe acquisition of high- quality blood products.
The purpose of this utility model is a tube which, through its shape, ensures proper centrifugation and obtaining blood products with a high concentration of platelets in the blood plasma.
The object of the utility model is a centrifuge tube, which in the upper part of the round body is in a shape which narrows upwards in the form of a neck on the circumference of which there are four stabilizers: in the lower part the tube body there is a thread.
Tube, the stabilizers of which are in the shape of rings.
Tube which has a cap with a closure at the end of the neck.
Tube, where the thread of the tube body has a round nut. Tube, where the round nut has the base of the tube cap and the tube stopper with spin- formed sides.
Description of the figures.
Fig. 1 - shows the tube in front view with a scale
Fig. 2 - shows the tube in the rear view with a scale.
Fig- 3 - shows A) the base of the tube stopper (indication 8), B) the tube stopper (indication 7), C) the round nut of the lower part of the tube body in top and side view (indication 5);
Fig. 4 - shows an unfolded tube.
Fig. 5 - shows the tube in its entirety (folded).
Fig. 6 - shows the tube in its entirety (folded) in the top view.
Fig. 7 - shows the tube in its entirety (folded) in the view from below.
Fig. 8 - shows the tube in its entirety (folded) in a top view.
Tube, which is the subject of the utility model, is shown in Figures 1 -8, which shows its structure in the front view.
Tube according to the formula has a cylindrical shape (round body (3)) tapering upwards to form a neck (2), on the circumference of which there are four stabilizers (1) in the form of rings; in the lower part, the body of the tube (3) there is a thread (4), on which a round nut is applied (5). The elements of the tube are the tube stopper (7), the base of the tube cap (8) and the tube nut (5). The tube stopper (7) is pressed from the bottom to the centre of the tube (3). Then, in the middle part of the tube stopper (7), the base of the tube stopper (8) is placed by pressing. Then a round nut (5) is wound on the thread (4), thereby closing the tube (3) from the bottom. At the end of the neck (2) there is a plug with a closure (6).
As shown in Fig. 1-8, the construction of the tube made of a special polymer - polycarbonate is characterized by low surface bonding energy. The usage of specially selected raw materials in the production means that the tube does not bind cytokines and growth factors during the procedure for the preparation of blood-derived autologous products and does not affect their final concentration in the finally prepared product ready for injection.
In order to improve the stability' and balance during centrifugation, the tube has been enriched with additional stabilizers (1) in its upper part. These stabilizers (1), in the form of regular rings around the neck (2) of the tube (3), allow for better distribution of the tube mass during the centrifugation process, which significantly improves the efficiency of blood separation into fractions. In addition, thanks to the scale placed directly on the neck of the tube (2), it is possible to collect from the tube very accurately (3) separated fractions of autologous preparations, characterized by a high concentration of blood morphotic elements.
Thanks to the described unique features of the tube, during a quick procedure it is possible to obtain high-quality PRP (Platelet rich plasma) or iPRF (injectable platelet rich fibrin) with increased regenerative properties.
List of indications:
1 - means ring-shaped stabilizers
2 — means the neck of the tube
3 — means the body of the tube
4 - means thread
5 — means round nut
6 — means a stopper with a closure (for closing the neck (2)). - means the tube stopper with spin-formed outer sides. - means the base of the tube stopper.

Claims

Claims: Centrifuge tube characterized in that in the upper part of the round body (3) is in a shape which narrows upwards in the form of a neck (2) on the circumference of which there are four stabilizers (1); in the lower part the tube body (3) has a thread (4). Tube according to claim 1 , characterized in that the stabilizers (1) are in the shape of rings. Tube according to claim 1 , characterized in that at the end of the neck (2) there is a stopper with a closure (6). Tube according to claim 1 , characterized in that the thread (4) of the tube body (3) has a round nut (5). Tube according to claim 1, characterized in that the round nut (5) has the base of the tube cap (8) and the tube stopper (7) with spin-formed outer sides.
PCT/PL2021/000091 2020-12-11 2021-12-10 Tube WO2022124918A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP21859344.0A EP4259331A1 (en) 2020-12-11 2021-12-10 Tube

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PLW.129684 2020-12-11
PL129684U PL72700Y1 (en) 2020-12-11 2020-12-11 Tube

Publications (1)

Publication Number Publication Date
WO2022124918A1 true WO2022124918A1 (en) 2022-06-16

Family

ID=78719809

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2021/000091 WO2022124918A1 (en) 2020-12-11 2021-12-10 Tube

Country Status (3)

Country Link
EP (1) EP4259331A1 (en)
PL (1) PL72700Y1 (en)
WO (1) WO2022124918A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101563512B1 (en) * 2015-04-09 2015-10-28 기 수 한 Blood separating vial
US20160032348A1 (en) * 2008-10-31 2016-02-04 Biomerieux, Inc. Separation device for use in the separation, characterization and/or identification of microorganisms
US20170368560A1 (en) * 2016-06-27 2017-12-28 Flotek Chemistry, Llc Centrifuge container adapter and related articles, systems, and methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160032348A1 (en) * 2008-10-31 2016-02-04 Biomerieux, Inc. Separation device for use in the separation, characterization and/or identification of microorganisms
KR101563512B1 (en) * 2015-04-09 2015-10-28 기 수 한 Blood separating vial
US20170368560A1 (en) * 2016-06-27 2017-12-28 Flotek Chemistry, Llc Centrifuge container adapter and related articles, systems, and methods

Also Published As

Publication number Publication date
EP4259331A1 (en) 2023-10-18
PL72700Y1 (en) 2022-09-05
PL129684U1 (en) 2021-11-22

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