WO2022110550A1 - 一种功效促进组合物及其应用 - Google Patents
一种功效促进组合物及其应用 Download PDFInfo
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- WO2022110550A1 WO2022110550A1 PCT/CN2021/075783 CN2021075783W WO2022110550A1 WO 2022110550 A1 WO2022110550 A1 WO 2022110550A1 CN 2021075783 W CN2021075783 W CN 2021075783W WO 2022110550 A1 WO2022110550 A1 WO 2022110550A1
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- Prior art keywords
- salt
- hyaluronic acid
- composition
- weight
- mass percentage
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 74
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 66
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 64
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 64
- 150000003839 salts Chemical class 0.000 claims abstract description 41
- 239000000047 product Substances 0.000 claims abstract description 29
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 18
- 238000000855 fermentation Methods 0.000 claims abstract description 18
- 230000004151 fermentation Effects 0.000 claims abstract description 18
- 239000000706 filtrate Substances 0.000 claims abstract description 18
- 235000009566 rice Nutrition 0.000 claims abstract description 18
- SSISHJJTAXXQAX-ZETCQYMHSA-N L-ergothioneine Chemical compound C[N+](C)(C)[C@H](C([O-])=O)CC1=CNC(=S)N1 SSISHJJTAXXQAX-ZETCQYMHSA-N 0.000 claims abstract description 17
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 17
- 229940093497 ergothioneine Drugs 0.000 claims abstract description 17
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims abstract description 16
- OTPDWCMLUKMQNO-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrimidine Chemical compound C1NCC=CN1 OTPDWCMLUKMQNO-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229940124277 aminobutyric acid Drugs 0.000 claims abstract description 14
- 240000007594 Oryza sativa Species 0.000 claims abstract 3
- 239000002537 cosmetic Substances 0.000 claims description 11
- 229920000642 polymer Polymers 0.000 claims description 11
- 239000003755 preservative agent Substances 0.000 claims description 11
- 230000002335 preservative effect Effects 0.000 claims description 10
- SCVVSSZVLZQUDZ-UHFFFAOYSA-N 3-methyl-2,6-dihydro-1H-pyrimidine-2-carboxylic acid Chemical compound CN1C(NCC=C1)C(=O)O SCVVSSZVLZQUDZ-UHFFFAOYSA-N 0.000 claims description 9
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 6
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 4
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 4
- YZNOBXJSQQGMCV-UHFFFAOYSA-N 3-(hydroxymethyl)-2,6-dihydro-1H-pyrimidine-2-carboxylic acid Chemical compound OCN1C(NCC=C1)C(=O)O YZNOBXJSQQGMCV-UHFFFAOYSA-N 0.000 claims description 3
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 3
- 229940051250 hexylene glycol Drugs 0.000 claims description 3
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000003020 moisturizing effect Effects 0.000 abstract description 28
- 239000004615 ingredient Substances 0.000 abstract description 22
- 230000000694 effects Effects 0.000 abstract description 11
- 238000010521 absorption reaction Methods 0.000 abstract description 8
- 150000003384 small molecules Chemical class 0.000 abstract description 3
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- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 description 19
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 19
- 235000013793 astaxanthin Nutrition 0.000 description 19
- 229940022405 astaxanthin Drugs 0.000 description 19
- 239000001168 astaxanthin Substances 0.000 description 19
- 229920002385 Sodium hyaluronate Polymers 0.000 description 18
- 229940010747 sodium hyaluronate Drugs 0.000 description 18
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 18
- 241000209094 Oryza Species 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 239000004480 active ingredient Substances 0.000 description 8
- 230000003712 anti-aging effect Effects 0.000 description 6
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- 238000000034 method Methods 0.000 description 6
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- 230000001737 promoting effect Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 4
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- 210000004207 dermis Anatomy 0.000 description 3
- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical compound CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 description 3
- 230000006870 function Effects 0.000 description 3
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- 230000002195 synergetic effect Effects 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 description 2
- 229940044176 ceramide 3 Drugs 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 239000000516 sunscreening agent Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- LPMKADABKPYRHE-UHFFFAOYSA-N 2-aminobutanoic acid Chemical compound CCC(N)C(O)=O.CCC(N)C(O)=O LPMKADABKPYRHE-UHFFFAOYSA-N 0.000 description 1
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- RDFLLVCQYHQOBU-GPGGJFNDSA-O Cyanin Natural products O([C@H]1[C@H](O)[C@H](O)[C@H](O)[C@H](CO)O1)c1c(-c2cc(O)c(O)cc2)[o+]c2c(c(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O3)cc(O)c2)c1 RDFLLVCQYHQOBU-GPGGJFNDSA-O 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 208000002197 Ehlers-Danlos syndrome Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
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- 230000006750 UV protection Effects 0.000 description 1
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- 239000013543 active substance Substances 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- RDFLLVCQYHQOBU-ZOTFFYTFSA-O cyanin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=[O+]C1=CC(O)=C2)C=3C=C(O)C(O)=CC=3)=CC1=C2O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 RDFLLVCQYHQOBU-ZOTFFYTFSA-O 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 229940100524 ethylhexylglycerin Drugs 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 102000007236 involucrin Human genes 0.000 description 1
- 108010033564 involucrin Proteins 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- HAYPRAKLPMTBOC-UHFFFAOYSA-N methyl 1,2,3,4-tetrahydropyrimidine-2-carboxylate Chemical compound COC(=O)C1NCC=CN1 HAYPRAKLPMTBOC-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
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- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Definitions
- the invention belongs to the field of biomedicine, and in particular relates to an efficacy promoting composition and application thereof.
- the prerequisite for the maximum effect of cosmetics is that the active ingredients have good permeability and activity, and improve the utilization rate of active ingredients.
- Transdermal absorption of cosmetics refers to the process in which functional ingredients in cosmetics act on the surface of the skin or enter the epidermis or dermis according to the effectiveness of the product, and accumulate and play a role in this part.
- the transdermal absorption of cosmetic functional ingredients does not need to enter the systemic circulation through the skin, which is the main difference between it and drugs.
- an efficacy-promoting composition which can not only promote the penetration and absorption of the active ingredients according to the different positions where different functional ingredients play their roles, enable the active ingredients to achieve precise positioning, quickly exert skin care effects, but also improve the stability of the functional ingredients. , to increase the contact time between the functional ingredients and the skin, thereby improving the utilization rate of the functional ingredients.
- the purpose of the present invention is to provide an efficacy promoting composition, which can effectively improve the penetration and absorption of functional components and the stability of functional components while moisturizing and replenishing water, thereby improving the utilization rate of functional components and improving skin condition.
- the present invention relates to the following aspects:
- compositions for promoting efficacy characterized in that the composition comprises macromolecular hyaluronic acid or its salt, hydrolyzed hyaluronic acid or its salt, acetylated hyaluronic acid or its salt, tetrahydropyrimidine or its derivatives substances, ergothioneine, yeast/rice fermentation product filtrate, aminobutyric acid.
- the composition according to item 1 characterized in that, in the composition, the mass percentage of the polymer hyaluronic acid or its salt is 1-30%, preferably 1-10%, and the hydrolysis
- the mass percentage of hyaluronic acid or its salt is 2%-50%, preferably 2-10%, and the mass percentage of the acetylated hyaluronic acid or its salt is 1-10%, preferably 1-1.5%, so
- the mass percentage of the tetrahydropyrimidine or its derivative is 0.1%-10%, preferably 0.3-5%
- the mass percentage of the ergothioneine is 2-20%, preferably 3-10%
- the mass percentage of the bacteria/rice fermentation product filtrate is 10-50%, preferably 15-40%, and the mass percentage of the aminobutyric acid is 0.1-5%, preferably 0.3-3%.
- composition according to item 1 or 2 characterized in that, in parts by weight, the polymer hyaluronic acid or its salt is 1 part by weight, and the hydrolyzed hyaluronic acid or its salt is 0.2-2
- the weight part is preferably 0.5-1 weight part
- the acetylated hyaluronic acid or its salt is 0.05-1.5 weight part, preferably 0.1-0.5 weight part.
- composition according to any one of items 1 to 6, wherein the tetrahydropyrimidine or its derivative is selected from one of tetrahydromethylpyrimidinecarboxylic acid and hydroxytetrahydromethylpyrimidinecarboxylic acid one or two, preferably tetrahydromethylpyrimidine carboxylic acid.
- composition according to any one of items 1-7, characterized in that, the composition further comprises a preservative, and the mass percentage of the preservative in the composition is 0.1-5%, the The preservative is selected from one or more of pentanediol, hexylene glycol, butanediol and ethylhexylglycerin.
- a skin care product or cosmetic comprising the composition of any one of items 1-8.
- Acetylated hyaluronic acid connects polymer hyaluronic acid with specific molecular weight and hydrolyzed hyaluronic acid in a specific ratio to build a stable "I"-shaped channel in three-dimensional space, forming a moisturizing and water-locking layer from the skin surface to the skin
- the long-term moisturizing channel of the deep moisturizing layer can effectively replenish moisture and increase skin moisture content
- the "G"-shaped efficacy promotion system constructed with 7 ingredients can improve the stability of macromolecular functional ingredients and increase the contact time with the skin while moisturizing and repairing the skin, thereby improving the utilization of macromolecular functional ingredients. On the other hand, it can increase the transdermal absorption effect of small-molecule functional components through the "I"-shaped channel, and increase the small molecular weight. The availability of molecular efficacy components.
- the mass percentage of the polymer hyaluronic acid or its salt is 1-30%, for example, it can be 1%, 5%, 10%, 15%, 20%, 25%, 30% , preferably 1-10%.
- the mass percentage of the hydrolyzed hyaluronic acid or its salt is 2%-50%, for example, it can be 2%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45% %, 50%, preferably 2-10%
- the mass percentage of the acetylated hyaluronic acid or its salt is 1-10%, such as 1%, 1.2%, 1.5%, 2%, 3%, 4% %, 5%, 6%, 7%, 8%, 9%, 10%, preferably 1-1.5%.
- the mass percentage of the tetrahydropyrimidine or its derivative is 0.1%-10%, for example, it can be 0.1%, 0.3%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, preferably 0.3-5%.
- the mass percentage of the ergothioneine is 2-20%, can be 2%, 3%, 5%, 10%, 15%, 20%, preferably 3-10%.
- the mass percentage of the yeast/rice fermentation product filtrate is 10-50%, such as 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, preferably 15-40%.
- the mass percentage of the aminobutyric acid is 0.1-5%, such as 0.1%, 0.3%, 0.5%, 1%, 2%, 3%, 4%, 5%, preferably 0.3-3%.
- Hyaluronic Acid is a kind of macromolecular polysaccharide that naturally exists in the interstitial species of human tissues and cells. It is widely used in medicine, skin care products, food and other fields. It has a variety of different molecular weights. HA has different functions and performances. High-molecular HA has excellent film-forming and water-locking functions. Low-molecular hydrolyzed HA can penetrate the skin and deeply hydrate the skin. Acetylated HA can be used as a bridge connecting the skin surface and hydrolyzed HA. , is a natural and effective moisturizing factor and water-locking factor.
- the molecular weight of the high molecular weight hyaluronic acid or its salt is 1000-1800kDa, for example, it can be 1000kDa, 1100kDa, 1200kDa, 1300kDa, 1400kDa, 1500kDa, 1600kDa, 1700kDa, 1800kDa, preferably 1000- 1500kDa.
- the molecular weight of the hydrolyzed hyaluronic acid or its salt is 1kDa-10kDa, such as 1kDa, 2kDa, 3kDa, 4kDa, 5kDa, 6kDa, 7kDa, 8kDa, 9kDa, 10kDa, preferably 5kDa-10kDa.
- the molecular weight of the acetylated hyaluronic acid or its salt is 20kDa-100kDa, for example, it can be 20kDa, 30kDa, 40kDa, 50kDa, 60kDa, 70kDa, 80kDa, 90kDa, 100kDa.
- the mass percentage of acetyl groups in the acetylated hyaluronic acid or its salt is 20-40%, for example, it can be 20%, 25%, 30%, 35%, 40%.
- Tetrahydromethylpyrimidine carboxylic acid is the most widely distributed compatible solute found in the bacterial kingdom. It is compatible with intracellular metabolism and does not affect the biological macromolecular or physiological functions of cells. Important osmotic compensation solutes. Due to the dense charge distribution on the surface of Ecto, it can further strengthen the hydrogen bond between water molecules through the electrostatic interaction with water molecules, reduce water activity, complex water molecules, and have a long-term moisturizing effect. Through its own high-density charge, it strengthens the hydrogen bond between water molecules to achieve long-term moisturizing; because it has excellent hydrophilicity, through the above-mentioned I-shaped structure, the skin barrier can be repaired more efficiently. damage.
- the tetrahydropyrimidine or its derivative is selected from one or both of tetrahydromethylpyrimidine carboxylic acid and hydroxytetrahydromethylpyrimidine carboxylic acid, preferably tetrahydromethylpyrimidine carboxylic acid.
- Ergothioneine is distributed in some tissues and organs of mammals. It is a natural antioxidant that can be produced by fermentation. It can protect cells in the human body and has UV protection. important active substances in the body. Through the synergistic effect with ECTOIN, it can effectively protect the skin barrier and ensure the operation of the "I"-shaped structure formed by sodium hyaluronate and its derivatives.
- Aminobutyric acid can promote the proliferation of epidermal cells and the production of keratinocyte involucrin, repair the stratum corneum barrier, reduce UV damage to the skin, and improve cell activity.
- Ectrahydropyrimidine or its derivatives, ergothioneine, yeast/rice fermented product filtrate, aminobutyric acid can effectively protect the skin barrier and ensure the stability and durability of the film formed by polymer HA on the skin surface, thereby ensuring transparency Efficient operation of the "I"-shaped structure formed by sodium phosphate and its derivatives.
- the composition also includes a preservative, the preservative is selected from one or more of pentanediol, hexylene glycol, butanediol and ethylhexylglycerol, and the preservative is in the composition.
- the mass percentage is 0.1-5%.
- the present invention also provides the application of the above composition in skin care products or cosmetics.
- the efficacy-promoting composition of the present invention comprises macromolecular hyaluronic acid, hydrolyzed hyaluronic acid, acetylated hyaluronic acid, tetrahydropyrimidine, ergothioneine, yeast/rice fermentation product filtrate and aminobutyric acid in specific proportions, and has Effective efficacy boosts function. For example, it can significantly promote hydration, improve the stability of active ingredients, and improve the absorption of anti-aging ingredients.
- the materials, reagents, etc. used in the following examples can be obtained from commercial sources unless otherwise specified.
- high molecular weight sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate, tetrahydromethylpyrimidine carboxylic acid, ergothioneine, yeast/rice fermentation product filtrate, aminobutyric acid are all from Huaxi Biotechnology Co., Ltd.
- Example 2 The difference between Examples 2-13, Comparative Examples 1-8 and Example 1 is the molecular weight or content of high molecular weight sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate, tetrahydromethylpyrimidine carboxylate
- the contents of acid, ergothioneine, yeast/rice fermentation product filtrate and aminobutyric acid are different, as shown in Table 1.
- Example 9 and Example 1 is only in the molecular weight of sodium hyaluronate; the difference between Example 10 and Example 1 is only in the content of sodium hyaluronate; Example 11 and Example 1 The difference is only in the content of hydrolyzed sodium hyaluronate; the difference between Example 12 and Example 1 is only in the molecular weight of hydrolyzed sodium hyaluronate; the difference between Example 13 and Example 1 is the amount of acetylated sodium hyaluronate. The content is different.
- the number of people tested is 10, and the average water content is taken.
- the comparative examples 1-3 only contain two of the three hyaluronic acids, and the hydrating effect is poor. This may be because the three hyaluronic acids of the present invention can build a stable "I"-shaped channel in the three-dimensional space, It forms a long-term moisturizing channel from the moisturizing and locking layer on the skin surface to the deep moisturizing layer of the skin, which can effectively replenish moisture and increase skin water content.
- the utilization rate of amide-3 enhances the moisturizing effect.
- Comparative Examples 4-8 The moisturizing effect of Comparative Examples 4-8 is also poor, among which Comparative Example 8 has the worst moisturizing effect, and the difference in skin water content before and after use is only 0.21, which may be due to tetrahydropyrimidine, ergothioneine, yeast/rice fermentation
- the synergistic effect of the product filtrate and aminobutyric acid can maintain the stability and durability of the film formed by high molecular hyaluronic acid on the skin surface, thereby ensuring the high efficiency of the "I"-shaped structure formed by sodium hyaluronate and its derivatives. run.
- test example 2 The protective effect of test example 2 on active ingredients
- Astaxanthin was added to the efficacy-promoting compositions prepared in Examples 1-13 and Comparative Examples 1-8, so that the mass percentage of astaxanthin in the composition was 0.01% to obtain astaxanthin-containing compositions, which were respectively applied accordingly.
- Example 1-16 The astaxanthin composition obtained in Example 1 corresponds to Application Example 1, the astaxanthin composition obtained in Example 2 corresponds to Application Example 2, and so on.
- the astaxanthin composition obtained in Example 8 corresponds to Application Example 8.
- the astaxanthin composition obtained in Example 13 corresponds to Application Example 13
- the astaxanthin composition obtained in Comparative Example 1 corresponds to Application Example 14
- the astaxanthin composition obtained in Comparative Example 2 corresponds to Application Example 15, and the shrimp obtained in Comparative Example 8
- the cyanin composition corresponds to Application Example 21.
- Astaxanthin is easily oxidized to lighten the color. The lighter the color, the more oxidized astaxanthin is, and the worse the efficacy of astaxanthin.
- the color of astaxanthin is not obvious, especially the color change of Examples 1-4 is the smallest, and the absorbance is only reduced by 0.0391-0.0969 compared with the control which is kept in a dark and airtight state.
- the color of the astaxanthin composition of the comparative example changed greatly, and the absorbance decreased by more than 0.3. This shows that the efficacy promotion system constructed by the seven components of the present invention can improve the stability of macromolecular functional components such as astaxanthin, increase the contact time between astaxanthin and the skin, and thereby improve the utilization rate of astaxanthin.
- Example 1 Comparative Example 1, and Comparative Example 8, 1% of wrinkle-removing ingredients (anti-wrinkle complex peptide) were added respectively to obtain a composition with anti-aging effect, corresponding to Application Examples 22, 23, and 24, respectively.
- Application examples 22, 23, and 24 are applied in different areas twice a day for 12 weeks, and the skin age data is recorded with Visia every 2 weeks.
- test number is 10 people, and the average skin age is taken.
- the efficacy-promoting composition prepared in the embodiment of the present invention can well promote the efficacy of the anti-aging ingredients. It can be seen from the above table that the efficacy of the anti-aging ingredients in Application Example 22 increases significantly. The skin age was reduced by 6 years, while the skin age of Application Example 23 and Application Example 24 changed little or hardly changed after a period of use.
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Abstract
Description
含水量(初始值) | 含水量(涂抹后) | |
区域1 | 36.71 | 45.33 |
区域2 | 35.42 | 42.87 |
区域3 | 36.34 | 44.76 |
区域4 | 35.89 | 43.76 |
区域5 | 36.03 | 40.22 |
区域6 | 36.07 | 39.46 |
区域7 | 36.12 | 40.21 |
区域8 | 36.08 | 39.72 |
区域9 | 35.94 | 40.11 |
区域10 | 36.00 | 39.42 |
区域11 | 36.02 | 40.15 |
区域12 | 36.04 | 40.24 |
区域13 | 36.07 | 39.73 |
区域14 | 36.11 | 37.00 |
区域15 | 36.01 | 36.59 |
区域16 | 35.98 | 36.91 |
区域17 | 36.00 | 37.10 |
区域18 | 36.01 | 37.23 |
区域19 | 35.99 | 37.01 |
区域20 | 36.02 | 37.34 |
区域21 | 36.03 | 36.24 |
区域22 | 36.07 | 36.11 |
吸光度 | |
应用例1 | 0.6579 |
应用例2 | 0.6001 |
应用例3 | 0.6388 |
应用例4 | 0.6320 |
应用例5 | 0.4889 |
应用例6 | 0.4521 |
应用例7 | 0.4711 |
应用例8 | 0.4602 |
应用例9 | 0.4800 |
应用例10 | 0.4603 |
应用例11 | 0.4801 |
应用例12 | 0.4833 |
应用例13 | 0.4698 |
应用例14 | 0.3410 |
应用例15 | 0.3908 |
应用例16 | 0.3922 |
应用例17 | 0.3801 |
应用例18 | 0.3856 |
应用例19 | 0.3846 |
应用例20 | 0.3868 |
应用例21 | 0.3602 |
对照 | 0.6970 |
0周 | 2周 | 4周 | 6周 | 8周 | 10周 | 12周 | |
应用例22 | 56 | 56 | 54 | 53 | 52 | 51 | 50 |
应用例23 | 56 | 56 | 56 | 55 | 55 | 54 | 54 |
应用例24 | 56 | 56 | 56 | 56 | 55 | 55 | 55 |
Claims (10)
- 一种功效促进组合物,其特征在于,所述组合物包括高分子透明质酸或其盐、水解透明质酸或其盐、乙酰化透明质酸或其盐、四氢嘧啶或其衍生物、麦角硫因、酵母菌/大米发酵产物滤液、氨基丁酸。
- 根据权利要求1所述的组合物,其特征在于,所述组合物中,所述高分子透明质酸或其盐的质量百分比为1-30%,优选为1-10%,所述水解透明质酸或其盐的质量百分比为2%-50%,优选为2-10%,所述乙酰化透明质酸或其盐的质量百分比为1-10%,优选为1-1.5%,所述四氢嘧啶或其衍生物的的质量百分比为0.1%-10%,优选为0.3-5%,所述麦角硫因的质量百分比为2-20%,优选为3-10%,所述酵母菌/大米发酵产物滤液的质量百分比为10-50%,优选为15-40%,所述氨基丁酸的质量百分比为0.1-5%,优选为0.3-3%。
- 根据权利要求1或2所述的组合物,其特征在于,按重量份计,所述高分子透明质酸或其盐为1重量份,所述水解透明质酸或其盐为0.2-2重量份,优选为0.5-1重量份,所述乙酰化透明质酸或其盐为0.05-1.5重量份,优选为0.1-0.5重量份。
- 根据权利要求1-3任一项所述的组合物,其特征在于,所述高分子量透明质酸或其盐的分子量为1000-1800kDa,优选为1000-1500kDa。
- 根据权利要求1-4任一项所述的组合物,其特征在于,所述水解透明质酸的分子量为1kDa-10kDa,优选为5kDa-10kDa。
- 根据权利要求1-5任一项所述的组合物,其特征在于,所述乙酰化透明质酸或其盐的分子量为20kDa-100kDa,乙酰基的质量百分比为20-40%。
- 根据权利要求1-6任一项所述的组合物,其特征在于,所述四氢嘧啶或其衍生物选自四氢甲基嘧啶羧酸和羟基四氢甲基嘧啶羧酸中的一种或两种,优选为四氢甲基嘧啶羧酸。
- 根据权利要求1-7任一项所述的组合物,其特征在于,所述组合物还包括防腐剂,所述防腐剂在所述组合物中的质量百分比为0.1-5%,所述防腐剂选自戊二醇、己二醇、丁二醇和乙基己基甘油中的一种或两种以上。
- 权利要求1-8任一项所述的组合物在护肤品或化妆品中的应用。
- 一种护肤品或化妆品,其包含权利要求1-8任一项所述的组合物。
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WO2024012486A1 (zh) * | 2022-07-12 | 2024-01-18 | 华熙生物科技股份有限公司 | 超分子结构、制备方法及其应用 |
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