WO2022096258A1 - Utilisation de glycérine pour inhiber la croissance de microbes - Google Patents

Utilisation de glycérine pour inhiber la croissance de microbes Download PDF

Info

Publication number
WO2022096258A1
WO2022096258A1 PCT/EP2021/078931 EP2021078931W WO2022096258A1 WO 2022096258 A1 WO2022096258 A1 WO 2022096258A1 EP 2021078931 W EP2021078931 W EP 2021078931W WO 2022096258 A1 WO2022096258 A1 WO 2022096258A1
Authority
WO
WIPO (PCT)
Prior art keywords
glycerol
malassezia
scalp
hair
composition
Prior art date
Application number
PCT/EP2021/078931
Other languages
English (en)
Inventor
Chung-Ching Chu
Michael John Hoptroff
Mingming PU
Qin Yin
Original Assignee
Unilever Ip Holdings B.V.
Unilever Global Ip Limited
Conopco, Inc., D/B/A Unilever
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Ip Holdings B.V., Unilever Global Ip Limited, Conopco, Inc., D/B/A Unilever filed Critical Unilever Ip Holdings B.V.
Publication of WO2022096258A1 publication Critical patent/WO2022096258A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Definitions

  • the present invention relates to use of glycerol for inhibiting growth of Malassezia and Staphylococcus capitis.
  • Dandruff is an issue that affects many people globally. The condition is manifested by the shedding of clumps of dead skin cells from the scalp. These are white in colour and provide an aesthetically displeasing appearance. A factor that contributes to dandruff are certain members of the Malassezia yeasts. To combat these, antidandruff products have been developed in the form of hair cleansing shampoos.
  • An example of a known anti-dandruff shampoo comprises sodium lauryl ether sulfate (an ethoxylated anionic surfactant) in combination with an anti-dandruff agent.
  • Typical antidandruff agents used in hair care are metal pyrithione e.g. zinc pyrithione (ZPTO), octopirox® (piroctone olamine), azole antimicrobials (e.g. climbazole), selenium sulfide and combinations thereof.
  • the scalp bacterial microbiome has recently become the focus of some attention for a potential causative role in dandruff progression.
  • the major fungal/bacterial species present on the scalp namely Malassezia restricta, Malassezia globosa, Cutibacterium acnes, Staphylococcus epidermidis and Staphylococcus capitis.
  • the Staphylococcus is one of the most abundant genera across both healthy and dandruff scalps.
  • Staphylococcus capitis is reported to be positively associated with dandruff conditions, while Staphylococcus epidermidis is positively associated with non-dandruff scalp conditions.
  • the invention provides the cosmetic use of glycerol as an active ingredient for inhibiting growth of Malassezia and Staphylococcus capitis.
  • the invention also provides glycerol for use as an active ingredient for inhibiting growth of Malassezia and Staphylococcus capitis.
  • the invention also provides the use of glycerol as an active ingredient in, and for the manufacture of, topical compositions for inhibiting growth of Malassezia and Staphylococcus capitis.
  • the invention provides the use of a hair care composition comprising glycerol for inhibiting growth of Malassezia and Staphylococcus capitis. This aspect may alternatively be described in the following way:
  • a hair care composition comprising glycerol for use as a medicament, preferably for use as a medicament in the inhibiting growth of Malassezia and Staphylococcus capitis.
  • the invention also provides a method of inhibiting growth of Malassezia and Staphylococcus capitis, comprising topically applying a hair care composition comprising glycerol to the hair and/or scalp of the an individual.
  • the invention also provides a hair care composition comprising glycerol for use in inhibiting growth of Malassezia and Staphylococcus capitis.
  • any feature of one aspect of the present invention may be utilized in any other aspect of the invention.
  • the word “comprising” is intended to mean “including” but not necessarily “consisting of or “composed of.” In other words, the listed steps or options need not be exhaustive. It is noted that the examples given in the description below are intended to clarify the invention and are not intended to limit the invention to those examples per se. Similarly, all percentages are weight/weight percentages unless otherwise indicated. Except in the operating and comparative examples, or where otherwise explicitly indicated, all numbers in this description and claims indicating amounts of material or conditions of reaction, physical properties of materials and/or use are to be understood as modified by the word "about”.
  • Numerical ranges expressed in the format “from x to y” are understood to include x and y. When for a specific feature multiple preferred ranges are described in the format “from x to y", it is understood that all ranges combining the different endpoints are also contemplated.
  • the indefinite article “a” or “an” and its corresponding definite article “the” means at least one, or one or more, unless specified otherwise.
  • the various features of the present invention referred to in individual sections above apply, as appropriate, to other sections mutatis mutandis. Consequently, features specified in one section may be combined with features specified in other sections as appropriate. Any section headings are added for convenience only and are not intended to limit the disclosure in any way.
  • “Hair care composition”, as used herein, is meant to include a composition for topical application to hair and/or scalp of mammals, especially humans. Such a composition may be generally classified as leave-on or rinse off, and includes any product applied to a human body for also improving appearance, cleansing, odor control or general aesthetics.
  • the composition of the present invention can be in the form of a liquid, lotion, cream, foam, scrub, gel, or bar. Non-limiting examples of such compositions include leave-on hair lotions, creams, and rinse-off shampoos, conditioners, shower gels, or toilet bar.
  • the present invention provides the use of glycerol as an active ingredient for inhibiting growth of Malassezia and Staphylococcus capitis.
  • the use is preferably non- therapeutic in nature, more preferably cosmetic in nature.
  • the glycerol for use in the present invention is variously known as glycerine, glycerin, and propane-1 , 2, 3-triol.
  • the glycerol may be used in substantially pure form or as part of a composition.
  • Glycerol has now been found to inhibit growth of Malassezia and Staphylococcus capitis.
  • the present inventors believe the glycerol can be fermented by scalp commensal microbe which is S. epidermidis or C. acnes, to produce metabolites such as short chain fatty acids.
  • the inventors surprisingly found that the glycerol which can be fermented by scalp commensal microbe which is S. epidermidis or C. acnes can inhibit the growth of Malassezia and Staphylococcus capitis. It is believed such inhibition is selective. Thus, it is believed such selective inhibition is achieved through fermentation by scalp commensal microbe which is S. epidermidis or C. acnes.
  • the present invention provides for glycerol or a composition comprising glycerol for inhibiting Malassezia and Staphylococcus capitis via fermentation by scalp commensal microbe, thereby alleviating the symptoms associated with dandruff.
  • glycerol or a composition comprising glycerol for inhibiting Malassezia and Staphylococcus capitis via fermentation by scalp commensal microbe, thereby alleviating the symptoms associated with dandruff.
  • Such use is preferably non-therapeutic, more preferably cosmetic.
  • the scalp commensal microbe is selected from S. epidermidis and C. acnes.
  • the present invention provides for glycerol or a composition comprising glycerol for inhibiting growth of Malassezia and Staphylococcus capitis.
  • glycerol or a composition comprising glycerol for inhibiting growth of Malassezia and Staphylococcus capitis is preferably non-therapeutic, more preferably cosmetic.
  • the glycerol for use according to the invention is suitably formulated into a personal care composition which is suitable for topical application to the hair and scalp.
  • Suitable personal care compositions for use in the invention include rinse-off or leave- on hair and scalp care compositions such as shampoos, conditioners, creams, lotions, gels, serums, mousses or oils. Rinse-off hair and scalp care compositions such as shampoos and conditioners are preferred.
  • the glycerol will generally be included in a composition for use in the invention at a level of from 0.1 to 30 wt%, preferably from 0.5 to 20 wt%, more preferably from 1 to 15 wt%, furthermore preferably 2 to 10 wt% by weight of the composition.
  • the hair care composition for use according to the invention is suitable for topical application to the hair and scalp.
  • Suitable hair care compositions for use in the invention include rinse-off or leave-on hair and scalp care compositions such as shampoos, conditioners, creams, lotions, gels, serums, mousses or oils. Rinse-off hair and scalp care compositions such as shampoos and conditioners are preferred.
  • compositions for use in the invention will generally include a cosmetically acceptable vehicle.
  • Cosmetically acceptable means that the vehicle is suitable for topical application to the skin, has good aesthetic properties, is compatible with the at least one biotin binding compound and the at least one precursor for biotin biosynthesis selected from pimelic acid and/or salts thereof and any other ingredients, and will not cause any safety or toxicity concerns.
  • the vehicle may comprise an aqueous phase, an oil phase, an alcohol, a silicone phase or a mixture thereof, and may be in the form of an emulsion.
  • Emulsions can have a range of consistencies including thin lotions (which may also be suitable for spray or aerosol delivery), creamy lotions, light creams and heavy creams.
  • compositions for use in the invention may also be formulated in a single-phase carrier such as a hydrophobic or hydrophilic liquid.
  • Suitable hydrophobic liquid carriers include liquid polyorganosiloxanes, mineral oils, hydrogenated polyisobutene, polydecene, paraffins and isoparaffins of at least 10 carbon atoms, aliphatic or aromatic ester oils (such as isopropyl myristate, lauryl myristate, isopropyl palmitate, diisopropyl sebacate, diisopropyl adipate and C12 to C15 alkyl benzoates), polyglycol ethers (such as polyglycol butanol ethers) and mixtures thereof.
  • Suitable hydrophilic liquid carriers include water, monohydric or polyhydric aliphatic alcohols having 2 to 8, preferably 2 or 3 carbon atoms (such as ethanol and isopropanol, oligoglycol ethers having 2 to 5 repeat units (such as dipropylene glycol) and mixtures thereof.
  • Liquid form compositions for use in the invention may be thickened, for example using one or more water soluble or colloidally water soluble polymeric thickening agents.
  • Suitable water soluble or colloidally water soluble polymeric thickening agents include hydroxyethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, polyquaternium-10, carrageenan, guar gum, hydroxypropyl guar gum, xanthan gum, polyvinylalcohol, acrylic acid/ethyl acrylate copolymers, carboxyvinyl polymers, crosslinked polyacrylate polymers and polyacrylamide polymers.
  • Preferred types of composition for use in the invention include shampoos, oils and lotions, more preferably shampoo, which are intended for topical application to the hair and scalp.
  • the pH of the composition for use according to the present invention is preferably equal to or higher than 4.0, more preferably in the range of 5.0 to 10.0.
  • Shampoo compositions for use in the invention are generally aqueous (i.e. they have water or an aqueous solution as their major component), and will suitably comprise from 50 to 98%, preferably from 60 to 90% water by weight of the total weight of the composition.
  • Shampoo compositions for use in the invention will typically comprise one or anionic surfactants such as sodium laureth sulfate, sodium oleyl succinate, ammonium lauryl sulfosuccinate, ammonium lauryl sulphate, sodium dodecylbenzene sulphonate, triethanolamine dodecylbenzene sulfonate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium N-lauryl sarcosinate, sodium lauryl sulfate, sodium lauryl ether sulfate (n) EO, (where n ranges from 1 to 3), ammonium lauryl sulfate and ammonium lauryl ether sulfate (n) EO, (where n ranges from 1 to 3) .
  • anionic surfactants such as sodium laureth sulfate, sodium oleyl succinate, ammonium lauryl sulfosuccinate,
  • the total amount of anionic surfactant in shampoo compositions for use in the invention generally ranges from 5 to 30%, preferably from 8 to 20% by weight of the total weight of the composition.
  • Shampoo compositions for use in the invention may also include co-surfactants such as nonionic surfactants, which can be included in an amount ranging from 0.5 to 8%, preferably from 2 to 5% by weight based on the total weight of the composition and/or amphoteric or zwitterionic surfactants, which can be included in an amount ranging from 0.5 to 8%, preferably from 1 to 4% by weight based on the total weight of the composition.
  • Representative nonionic surfactants include alkanolamides such as cocamide monoethanolamide and cocamide monoisopropanolamide; alkyl polyglucosides such as cocoglucoside and lauryl glucoside; and acyl glucamides such as cocoyl methyl glucamide.
  • Representive amphoteric surfactant includes cocamidopropyl betaine.
  • the shampoo composition for use in the invention comprises sodium laureth sulfate and co-surfactant which is cocamidopropyl betaine.
  • Shampoo compositions for use in the invention may also include one or more cationic polymers, which can be included in an amount ranging from 0.01 to 5%, preferably from 0.05 to 2% by weight based on the total weight of the composition.
  • Representative cationic polymers include cationic polysaccharide polymers such as cationic cellulose derivatives and cationic guar gum derivatives such as guar hydroxypropyltrimethylammonium chloride.
  • Shampoo compositions for use in the invention may also include one or more suspending agents, which can be included in an amount ranging from 0.05 to 5%, preferably from 0.1 to 3% (by weight based on the total weight of the composition).
  • suspending agents include polyacrylic acids, cross-linked polymers of acrylic acid, copolymers of acrylic acid with a hydrophobic monomer, copolymers of carboxylic acid-containing monomers and acrylic esters, cross-linked copolymers of acrylic acid and acrylate esters, heteropolysaccharide gums and crystalline long chain acyl derivatives such as ethylene glycol distearate.
  • Hair oils and lotions for use in the invention typically have an oil phase containing at one or more cosmetically acceptable fatty materials which may be liquid or solid at room temperature (25°C).
  • Lotions are typically aqueous emulsions having an aqueous phase in addition to the oil phase.
  • Suitable cosmetically acceptable fatty materials include naturally derived oils (such as sunflower oil, borage oil, soybean oil, castor oil, olive oil and almond oil); esters of monoalcohols or of polyols with monocarboxylic or polycarboxylic acids, at least one of the alcohols and/or acids comprising at least one hydrocarbon-based chain containing at least 6 carbon atoms (such as octyl palmitate, isopropyl myristate, isopropyl palmitate, isopropyl isostearate, hexyl laurate, isohexyl laurate, isohexyl palmitate, decyl oleate, isodecyl oleate, hexadecyl stearate, decyl stearate, dihexyldecyl adipate, lauryl lactate, myristyl lactate, cetyl lactate, oleyl stearate, oleyl ole
  • the aqueous phase of lotions for use in the invention may also include one or more organic liquids that are miscible with water at room temperature (25°C).
  • exemplary water-miscible organic liquids include monohydric and polyhydric alcohols and derivatives thereof such as C2-C6 alkanols (such as ethanol and isopropanol); C2-C10 glycols and polyols (such as glycerol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, caprylyl glycol, dipropylene glycol, and diethylene glycol); C3- C16 glycol ethers (such as mono-, di-, or tripropylene glycol (C1-C4) alkyl ethers and mono-, di-, or triethylene glycol (C1-C4) alkyl ethers) and polyethylene glycol having 2 to 12 oxyethylene units.
  • C2-C6 alkanols such as ethanol and isopropan
  • Lotions for use in the invention may also include surface active ingredients, such as emulsifiers and solubilizers, to enable two or more immiscible components to be combined homogeneously and to help stabilize the composition.
  • Emulsifiers that may be used to form O/W or W/O emulsions include sorbitan oleate, sorbitan sesquioleate, sorbitan isostearate, sorbitan trioleate, PEG-20 sorbitan isostearate, polyglyceryl-3- diisostearate, polyglycerol esters of oleic/isostearic acid, polyglyceryl-6 hexaricinolate, polyglyceryl-4-oleate, polyglyceryl-4 oleate/PEG-8 propylene glycol cocoate, polyglyceryl-2 dipolyhydroxystearate, PEG-30 dipolyhydroxystearate, oleamide DEA, TEA myristate, TEA stearate
  • Compositions for use in the invention may include additional actives for improving the physical and/or aesthetic characteristics of the scalp and/or the hair.
  • additional actives for improving the physical and/or aesthetic characteristics of the scalp and/or the hair.
  • examples include amino acids, vitamins, minerals and/or antioxidants, emollients, humectants, sunscreens, anti-irritants, exfoliating agents, botanical extracts (such as pomegranate, white birch, green tea, chamomile and licorice extracts) and mixtures thereof.
  • Compositions for use in the invention may include additional functional ingredients for improving the physical and/or aesthetic characteristics of the composition per se.
  • additional functional ingredients include inorganic pigments (such as titanium oxide, zirconium oxide, cerium oxide, zinc oxide, iron oxide, chromium oxide, manganese violet, ultramarine blue, chromium hydrate and ferric blue); organic pigments (such as carbon black and the organic lakes of barium, strontium, calcium or aluminium); pearlescent agents (such as mica coated with titanium oxide and/or iron oxide); dyes, preservatives (such as disodium EDTA, benzyl alcohol, methylparaben, phenoxyethanol, propylparaben, ethylparaben, butylparaben and isobutylparaben); pH adjusters and fragrances (such as essential oils, flower oils, natural extracts from resins, gums, balsams, beans, mosses and other plants, as well as synthetic aromatic materials).
  • inorganic pigments such as titanium oxide,
  • the present invention provides for a method of inhibiting growth of Malassezia and Staphylococcus capitis, comprising topically applying a hair care composition comprising glycerol to the hair and/or scalp of the an individual.
  • the method is preferably non-therapeutic in nature, more preferably cosmetic in nature.
  • the composition is suitably applied to the hair and scalp and massaged into the surface of the scalp.
  • an amount corresponding to about 1 to 15 ml of the composition per application is applied uniformly over the area of treatment daily or at least once a week over a time interval of at least 7 (seven) days, preferably at least 28 days, more preferably at least 30 (thirty) days.
  • the invention provides a hair care composition comprising glycerol for use in inhibiting growth of Malassezia and Staphylococcus capitis.
  • the examples 1-4 demonstrates the use of glycerol for inhibiting the dandruff associated microbes which are Malassezia and Staphylococcus capitis.
  • the examples 5-6 demonstrates the efficacy of glycerol on the growth of other microbes.
  • TSA Tryptic soy Agar
  • Modified Dixon 36 g/L Malt Extract, 6g/L Mycological Peptone, 10 g/L Purified Agar, 20 g/L Ox-bile, 2 mL/L Oleic acid, 2 mL/L Glycerol, 10 mL/L Tween 40
  • PB Pityrosporum Broth
  • RM Rich medium
  • S. epidermidis, and S. capitis were cultured on Tryptic soy agar plates (TSA) overnight at 37°C.
  • TSA Tryptic soy agar plates
  • a single colony was inoculated in Tryptic soy broth (TSB) and incubated overnight at 37°C. Then it was harvested by centrifugation at 5,000 g for 10 min, washed with PBS buffer, and resuspended in PBS to get the concentration of 10 A 10 CFU/mL
  • C. acnes was cultured on Reinforced Clostridium Medium (RCM) under anaerobic condition using at 37°C for 6 days. The inoculum was then diluted 1 :10 and cultured for 3 days. C. acnes was harvested by centrifugation at 5,000 g for 10 min, washed with PBS, and suspended in PBS buffer to get the concentration of 10 A 10 CFU/mL.
  • RCM Reinforced Clostridium Medium
  • M. furfur was cultured on Modified Dixon (MD) agar plates at 32°C for 3 days. Two loops of M. furfur were inoculated into 20 ml of Pityrosporum Broth (PB) medium and cultured for 3 days at 32°C with shaking at 120 rpm. The inoculum was then diluted 1 :10 and cultured for 2 days at 32°C. The culture was diluted with PB to a final concentration of 10 A 6 CFU/mL.
  • PB Pityrosporum Broth
  • S. epidermidis, and C. acnes (10 A 5 CFU/mL) were incubated in 10 mL Rich Media (RM) in the absence and presence of 2% glycerol under aerobic condition for S. epidermidis or anaerobic condition for C. acnes at 37°C with shaking at 200 rpm for 4 days.
  • RM Rich Media
  • the plate was put into the Tecan 2000C and incubated at 32 °C to monitor the fluoresence change (excitation 530nm/emmision 590nm) at 4-hours interval up to 20 hours.
  • the fluorescence was recorded as the indication of microbial growth.
  • Table-2 illustrates that the glycerol can be used to inhibit the growth of Malassezia furfur, which is within the scope of the present invention.
  • Table-3 illustrates that the glycerol can be used to inhibit the growth of Staphylococcus capitis, which is within the scope of the present invention.
  • Table-4 illustrates that the use of glycerol cannot inhibit the growth of Staphylococcus epidermidis which is a scalp commensal microbe, which is out of the scope of the present invention. It indicates that the efficacy of glycerol for inhibiting the growth of microbes is selective.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne l'utilisation cosmétique de glycérine en tant que principe actif pour inhiber la croissance de Malassezia et de Staphylococcus capitis.
PCT/EP2021/078931 2020-11-09 2021-10-19 Utilisation de glycérine pour inhiber la croissance de microbes WO2022096258A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2020127494 2020-11-09
CNPCT/CN2020/127494 2020-11-09
EP20214395 2020-12-16
EP20214395.4 2020-12-16

Publications (1)

Publication Number Publication Date
WO2022096258A1 true WO2022096258A1 (fr) 2022-05-12

Family

ID=81456967

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2021/078931 WO2022096258A1 (fr) 2020-11-09 2021-10-19 Utilisation de glycérine pour inhiber la croissance de microbes

Country Status (1)

Country Link
WO (1) WO2022096258A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115261274A (zh) * 2022-08-05 2022-11-01 天康制药(苏州)有限公司 一种表皮葡萄球菌高密度发酵培养基及其发酵方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015062821A1 (fr) * 2013-10-28 2015-05-07 Unilever N.V. Méthode de conditionnement du cuir chevelu pour résister aux pellicules
JP2019043898A (ja) * 2017-09-04 2019-03-22 花王株式会社 皮膚常在菌叢改善剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015062821A1 (fr) * 2013-10-28 2015-05-07 Unilever N.V. Méthode de conditionnement du cuir chevelu pour résister aux pellicules
JP2019043898A (ja) * 2017-09-04 2019-03-22 花王株式会社 皮膚常在菌叢改善剤

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HARDING CR ET AL: "A high glycerol-containing leave-on scalp care treatment to improve dandruff", vol. 12(3), 1 January 2014 (2014-01-01), pages 155 - 161, XP055810043, Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/pubmed/25134312> [retrieved on 20210602] *
J.W. FLUHR ET AL: "Glycerol and the skin: holistic approach to its origin and functions", BRITISH JOURNAL OF DERMATOLOGY, vol. 159, no. 1, 1 July 2008 (2008-07-01), pages 23 - 34, XP055114643, ISSN: 0007-0963, DOI: 10.1111/j.1365-2133.2008.08643.x *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115261274A (zh) * 2022-08-05 2022-11-01 天康制药(苏州)有限公司 一种表皮葡萄球菌高密度发酵培养基及其发酵方法和应用
CN115261274B (zh) * 2022-08-05 2023-11-21 天康制药股份有限公司 一种表皮葡萄球菌高密度发酵培养基及其发酵方法和应用

Similar Documents

Publication Publication Date Title
JP2020525428A (ja) 局所用組成物
JP2019524778A (ja) 抗菌性組成物
WO2022096258A1 (fr) Utilisation de glycérine pour inhiber la croissance de microbes
US20020164360A9 (en) Use of polyamino acid derivatives to treat seborrhoea and the associated skin disorders
EP3709955A1 (fr) Compositions topiques
JP7187740B2 (ja) 新規の使用
FR2826269A1 (fr) Utilisation de polyammonium quaternaire dans le traitement de l&#39;acne et des desordres cutanes lies a l&#39;hyperseborrhee
US11191772B2 (en) Use
JP4220769B2 (ja) 抗アクネ菌組成物
WO2024104742A1 (fr) Procédé d&#39;inhibition de croissance de microbes
WO2024061608A1 (fr) Procédé d&#39;inhibition de la croissance de malassezia restricta
EP3723711A1 (fr) Composition topique comprenant un lipide antimicrobien
US20150208649A1 (en) Novel compositions comprising p-hydroxybenzylamine
KR20190050358A (ko) 자화지정 추출물을 유효성분으로 포함하는 미생물 균총 개선용 조성물
US20230301889A1 (en) Method of preventing or reducing hair fall
EP4153123A1 (fr) Compositions et méthodes permettant d&#39;apporter des bénéfices pour le soin du cuir chevelu
KR102001244B1 (ko) 홍화자 추출물을 유효성분으로 포함하는 미생물 균총 개선용 조성물
US9980889B2 (en) Compositions comprising P-hydroxybenzylamine
KR20080011546A (ko) 금은화 추출물을 함유하는 저자극성 피부 외용제 조성물
KR100538142B1 (ko) 창포 오일을 포함하는 여드름 피부 개선을 위한 화장료조성물
WO2020229262A1 (fr) Compositions topiques
KR20190050346A (ko) 갈화 추출물을 유효성분으로 포함하는 미생물 균총 개선용 조성물
KR20190050351A (ko) 당귀 추출물을 유효성분으로 포함하는 미생물 균총 개선용 조성물
EP3709954A1 (fr) Compositions topiques
KR20190050355A (ko) 비파엽 추출물을 유효성분으로 포함하는 미생물 균총 개선용 조성물

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21790224

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21790224

Country of ref document: EP

Kind code of ref document: A1