WO2022013911A1 - Dispositif, procédé et programme de mesure de température - Google Patents

Dispositif, procédé et programme de mesure de température Download PDF

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Publication number
WO2022013911A1
WO2022013911A1 PCT/JP2020/027224 JP2020027224W WO2022013911A1 WO 2022013911 A1 WO2022013911 A1 WO 2022013911A1 JP 2020027224 W JP2020027224 W JP 2020027224W WO 2022013911 A1 WO2022013911 A1 WO 2022013911A1
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WIPO (PCT)
Prior art keywords
temperature
time
equation
estimated temperature
estimated
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PCT/JP2020/027224
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English (en)
Japanese (ja)
Inventor
大地 松永
雄次郎 田中
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日本電信電話株式会社
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Priority to JP2022535991A priority Critical patent/JP7464124B2/ja
Priority to PCT/JP2020/027224 priority patent/WO2022013911A1/fr
Publication of WO2022013911A1 publication Critical patent/WO2022013911A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K7/00—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements

Definitions

  • the present invention relates to a temperature measuring device, method and program for non-invasively and accurately measuring the temperature inside a living body.
  • Patent Document 1 Japanese Unexamined Patent Publication No. 2020-003291
  • sensor thermometer elements
  • FIG. 7 shows a schematic diagram of a pseudo one-dimensional model in the temperature measurement inside the living body 71.
  • the temperature Tcore inside the object to be measured (living body) 71 is near the surface (the surface in contact with the object) of the sensor 72 when an object (sensor) having thermal resistance Rs is placed on the surface of the object to be measured (living body) 71. It can be estimated from the temperature Tskin of the above and the temperature Tt near the back surface (the surface on the side in contact with the outside air) of the sensor 72 using the following equation.
  • Tcore Tskin + Rbody x Hskin
  • Rbody is the thermal resistance of the living body
  • Rs is the thermal resistance of the sensor.
  • FIG. 8 shows a comparison between the true internal temperature 81 and the estimated temperature 82 when the wind is blown by a fan.
  • the difference (error) between the true internal temperature 81 and the estimated temperature 82 is that when the wind exceeds a certain threshold, the heat transport mode changes from heat conduction to convection heat transfer, and the amount of heat transferred to the outside is Due to major changes.
  • the temperature measuring method is a temperature measuring method for measuring the temperature inside the living body based on the temperature detected by the sensor, and is a temperature measuring method inside the living body.
  • the estimated temperature of the temperature is the first equation based on the heat flux calculated by the difference between the temperature of one place near the living body and the temperature of the other place in the sensor, and the estimated temperature by the first formula. Calculated by either of the second equations to be corrected, the first estimated temperature at the first time before the time when the time differential of the heat flux exceeds the reference value and the time differential of the heat flux are the reference.
  • the difference between the second estimated temperature according to the first equation at the second time after the time exceeding the value, the first estimated temperature, and the second according to the second equation at the second time is characterized in that the difference from the estimated temperature of 3 is calculated, and the calculation formula of the estimated temperature is determined to be either the first formula or the second formula based on the two differences. ..
  • the temperature measuring method is a temperature measuring method for measuring the temperature inside the living body based on the temperature detected by the sensor, and is the first method in the vicinity of the surface in contact with the living body in the sensor.
  • the heat flux is calculated based on the step of measuring the temperature of the first temperature and measuring the second temperature at a position different from the position where the first temperature is measured, and the difference between the first temperature and the second temperature. Steps to detect the time when the time differential of the heat flux exceeds the reference value, the first equation for calculating the estimated temperature based on the heat flux, and the first equation for correcting the estimated temperature according to the first equation.
  • the temperature measuring device is a temperature measuring method for measuring the temperature inside the living body based on the temperature detected by the sensor, and is the first method in the vicinity of the surface in contact with the living body in the sensor.
  • the heat flux is calculated based on the step of measuring the temperature of the first temperature and measuring the second temperature at a position different from the position where the first temperature is measured, and the difference between the first temperature and the second temperature.
  • the temperature measurement program measures the temperature inside the living body based on the temperature detected by the sensor, and obtains the estimated temperature of the temperature inside the living body in the sensor. Either the first equation based on the heat flux calculated by the difference between the temperature at one location near the living body and the temperature at another location, or the second equation that corrects the estimated temperature according to the first equation.
  • the difference between the second estimated temperature according to the first equation, the first estimated temperature, and the third estimated temperature according to the second equation at the second time is calculated.
  • the temperature measuring device is made to function by executing a process of determining the estimated temperature calculation formula as either the first formula or the second formula based on the difference between the two. ..
  • the present invention it is possible to provide a temperature measuring device, a method and a program for non-invasively and accurately measuring the temperature inside a living body.
  • FIG. 1 is a schematic diagram of a change with time of temperature for explaining the temperature measuring method according to the first embodiment of the present invention.
  • FIG. 2 is a diagram showing a change over time in the time derivative of the heat flux for explaining the temperature measuring method according to the first embodiment of the present invention.
  • FIG. 3 is a block diagram showing a configuration of a temperature measuring device according to the first embodiment of the present invention.
  • FIG. 4 is a flowchart of the temperature measuring method according to the first embodiment of the present invention.
  • FIG. 5 is a diagram showing an example of the temperature measuring method according to the first embodiment of the present invention.
  • FIG. 6 is a diagram showing a configuration example of a computer according to an embodiment of the present invention.
  • FIG. 7 is a schematic diagram of a pseudo one-dimensional model in a conventional temperature measurement inside a living body.
  • FIG. 8 is a diagram showing changes over time in the deep temperature measured by the conventional method.
  • FIG. 1 is a schematic diagram of a change over time in temperature for explaining the method according to the present embodiment.
  • FIG. 1 is based on FIG. 8 described above, and shows a temperature change when a wind is applied.
  • the solid line 11 shows the true internal temperature
  • the dotted line 12 shows the estimated temperature Tcore calculated by the equation (1).
  • Tcore Tskin + Rbody x Hskin (1)
  • Hskin is a heat flux
  • Hskin (Tskin-Tt) / Rs, and is calculated from the difference between Tskin and Tt.
  • Tskin is the temperature near the front surface (for example, the surface in contact with the living body) of the sensor
  • Tt is the temperature near the back surface (the surface in contact with the outside air) of the sensor
  • Rbody is the thermal resistance of the living body
  • Rs is the heat of the sensor. It is resistance.
  • the estimated temperature 12 has an error as compared with the internal temperature 11, it is necessary to correct the estimated temperature 12 including this error in order to calculate an accurate estimated temperature.
  • the change in the estimated temperature 12 is gradual because it depends on the heat capacity of the living body and the sensor. Therefore, it is difficult to correct the estimated temperature 12 by detecting the heat transport mode by the change of the estimated temperature 12. Therefore, in the present embodiment, the change in the heat transport mode is detected by using the time derivative dHskin of the heat flux Hskin, and the error at the estimated temperature 12 is corrected.
  • FIG. 2 shows the time derivative dHskin of the heat flux Hskin with respect to the time course of the temperature shown in FIG. Unlike the change in the estimated temperature, the time derivative dHskin changes sharply when the heat transport mode changes and expresses steep peaks 21 and 22, so that it becomes easy to specify the time.
  • the estimated temperature Tcore can be corrected and calculated by the following formula.
  • Tcore Tskin + ⁇ x Rbody x Hskin (2)
  • the estimated temperature is calculated by both the equations (1) and (2) and compared with the estimated temperature before the detection of the convection change, which is more accurate. Determine the formula for calculating the estimated temperature. The details will be described below.
  • FIG. 3 shows a block diagram of the configuration of the temperature measuring device 30 according to the present embodiment.
  • the temperature measuring device 30 includes a measuring unit (sensor) 31, a storage unit 32, a calculation unit 33, and an output unit 34.
  • the measuring unit (sensor) 31 is arranged near the surface of the object to be measured (for example, a living body) in contact with the surface, and measures the temperature Tskin (first temperature) near the surface of the measuring unit (sensor) 31.
  • the thermometer element 1 and a second thermometer element for measuring the temperature Tt (second temperature) in the vicinity of the back surface of the measuring unit 31 (for example, the surface on the side in contact with the outside air) are provided.
  • the place where the temperature Tt is measured is not limited to the back surface of the measuring unit 31, and may be a place different from the place where the temperature Tskin is measured, and is separated from the place where the temperature Tskin is measured, that is, the first thermometer element. It is desirable that the location is.
  • the second thermometer element may be arranged at a position far enough away from the first temperature and the second temperature so that the heat flux can be accurately calculated.
  • thermometer elements are used, but the number is not limited to two and may be plural. It is possible to measure the heat flux more accurately by using a plurality of thermometer elements.
  • the temperature storage unit 321 stores the measurement time and the measurement temperature measured by the measurement unit 31, and the time constant, the reference value (threshold), and the correction coefficient required for the temperature measurement according to the present embodiment. , Etc. are memorized. Further, the estimated temperature storage unit 322 stores the estimated temperature calculated by the equation (1) and the equation (2) by the calculation unit 331 of the calculation unit 33.
  • the calculation unit 331 calculates the estimated temperature by the equations (1) and (2). In addition, the difference in estimated temperature before and after the detection time of the change in heat flux is calculated. Further, the calculation unit 331 calculates and calculates numerical values necessary for temperature measurement according to the present embodiment, such as heat flux and its time derivative.
  • the comparison unit 332 compares the time derivative dHskin of the heat flux calculated by the calculation unit 331 with the reference value. Further, regarding the difference in the estimated temperature calculated by the calculation unit 331, the difference based on the equation (1) and the difference based on the equation (2) are compared. In addition, the calculation formula of the estimated temperature is determined based on the result of the comparison.
  • the output unit 34 outputs (displays) the estimated temperature calculated by the equations (1) and (2).
  • the accurate temperature cannot be output, it is possible to output (display) a blank (state in which nothing is displayed) or the inability to measure the accurate temperature.
  • FIG. 4 shows a flowchart of the temperature measuring method according to the present embodiment.
  • Tt is measured (step 401).
  • the estimated temperature is calculated by the formula (1) (step 402).
  • the time derivative dHskin of the heat flux Hskin is calculated (step 403).
  • the dHskin is calculated as the difference between the heat flux Hskins at the adjacent sampling (measurement) times.
  • the interval between adjacent sampling (measurement) times is about 1 second.
  • Hskin (ta) ⁇ Tskin (ta) -Tt (ta) ⁇ / Rs.
  • Hskin (tb) ⁇ Tskin (tb) -Tt (tb) ⁇ / Rs. It is calculated by.
  • dHskin Hskin (tb) -Hskin (ta).
  • ta and tb do not have to be adjacent sampling (measurement) times, and may have a predetermined interval.
  • the dHskin value is compared with the reference value (hereinafter referred to as “convection detection threshold”) dHskin_thres (step 404).
  • dHskin_thres When dHskin is equal to or less than the convection detection threshold dHskin_thres (
  • dHskin_thres (
  • dHskin_thres the convection detection threshold dHskin_thres is set to, for example, 0.02 ° C./sec.
  • first time a time t0- ⁇ 1 (hereinafter referred to as “first time”) that is advanced by a predetermined time ⁇ 1 from the time t0 at which the change in heat flux is detected.
  • first estimated temperature a time t0- ⁇ 1 (hereinafter referred to as “first time”) that is advanced by a predetermined time ⁇ 1 from the time t0 at which the change in heat flux is detected.
  • first estimated temperature a temperature Tcore1 (hereinafter referred to as “first estimated temperature”) (step 405).
  • ⁇ 1 can be set from 60 seconds to 300 seconds.
  • the estimated temperature is calculated based on the equation (1).
  • the estimated temperature is calculated by correcting it with equation (2).
  • the estimated temperature Tcore2 (hereinafter, referred to as “second time”) calculated by the equation (1) at the time t0 + ⁇ 2 (hereinafter referred to as “second time”) after a predetermined time ⁇ 2 from the time t0 when the change in heat flux is detected.
  • the “second estimated temperature”) and the estimated temperature Tcore3 calculated by the equation (2) (hereinafter referred to as "third estimated temperature”) are acquired (step 406).
  • ⁇ 2 can be set to about 600 seconds. It is desirable that ⁇ 2 is 300 seconds to 1200 seconds.
  • the difference between the first estimated temperature and the second estimated temperature (
  • the difference between the first estimated temperature and the second estimated temperature is compared with the difference between the first estimated temperature and the third estimated temperature (step 408).
  • the formula for calculating the smaller difference between the second estimated temperature and the third estimated temperature that is, the formula (1) or the formula (2) is estimated. It is used as a temperature calculation formula.
  • FIG. 5 shows the time-dependent change 51 of the time derivative dHskin of the heat flux and the time-dependent change 52 of the estimated temperature in the temperature measuring method of the embodiment according to the present embodiment.
  • the time-dependent change 52 of the estimated temperature indicates an estimated temperature 521 calculated by the formula (1) and an estimated temperature 522 calculated by the formula (2) in order to explain the temperature measuring method of the present embodiment.
  • the time-dependent change 53 of the estimated temperature indicates the estimated temperature 531 by the temperature measuring method of the embodiment according to the present embodiment and the estimated temperature 532 by the temperature measuring method not considering the change of the external temperature as a comparative example. Further, the temperature measured by the eardrum is shown as the true internal temperature 530.
  • the estimated temperature 52 is calculated by the equation (1) because no convection has occurred.
  • the estimated temperature Tcore1 (first estimated temperature) at time t1- ⁇ 1 is selected in the estimated temperature stored in the estimated temperature storage unit 322. (Acquired) (white circle in the figure).
  • the estimated temperature 521 according to the equation (1) and the estimated temperature 522 according to the equation (2) are calculated, and at time t1 + ⁇ 2, the second estimated temperature Tcore2 (black triangle in the figure) which is the estimated temperature 521 according to the equation (1). And the third estimated temperature Tcore3 (black circle in the figure), which is the estimated temperature 522 by the equation (2), is calculated.
  • the first estimated temperature Tcore1 is obtained. Since the difference from the third estimated temperature Tcore3 is smaller, the formula (2) for calculating the third estimated temperature Tcore3 is adopted as the formula for calculating the estimated temperature to measure the temperature and calculate the estimated temperature. continue.
  • the estimated temperature (first estimated temperature) at time t2- ⁇ 1 is selected in the estimated temperature stored in the estimated temperature storage unit 322 (first estimated temperature). Acquired) (white circle in the figure).
  • the estimated temperature 521 according to the equation (1) and the estimated temperature 522 according to the equation (2) are calculated, and at time t1 + ⁇ 2, the second estimated temperature Tcore2 (black triangle in the figure) which is the estimated temperature 521 according to the equation (1). And the third estimated temperature Tcore3 (black circle in the figure), which is the estimated temperature 522 by the equation (2), is calculated.
  • the first estimated temperature Tcore1 is obtained. Since the difference from the third estimated temperature Tcore3 is smaller, the formula (2) for calculating the third estimated temperature Tcore3 is adopted as the formula for calculating the estimated temperature to measure the temperature and calculate the estimated temperature. continue.
  • the estimated temperature 531 calculated by the temperature measuring method of the embodiment according to the present embodiment is calculated by the equation (2) including the correction by the convection change after the time t1, and is the same temperature as the internal temperature 530. Is shown. Further, at time t2, the change in dHskin51 is due to the change in the external temperature, and the convection state does not change, that is, the convection does not end. Therefore, the estimated temperature is calculated from the equation (2) as before t2. The temperature is equivalent to the internal temperature of 530.
  • the estimated temperature 532 of the comparative example after the time t1, the estimated temperature is calculated by the equation (2) including the correction by the convection change, and shows the same temperature as the internal temperature 530.
  • the change in dHskin51 is due to the change in the external temperature, it is erroneously recognized as being due to the change in the convection state.
  • the estimated temperature is calculated from the equation (1), so that a difference (error) from the internal temperature 530 occurs.
  • the temperature measuring method it is possible to measure the temperature inside the living body with high accuracy without erroneously recognizing the convection change when the temperature change occurs.
  • the generation of convection and the end of convection can be detected by measuring the change of the time derivative dHskin of the heat flux in positive and negative directions. For example, when the change in dHskin is 0 or more, the change in the morphology of heat conduction accompanying the start of convection is detected, and when the change in dHskin is less than 0, the change in the morphology of heat conduction accompanying the end of convection is detected. , The convection period can be detected.
  • the calculation unit 33 sequentially uses the temperature measured by the measurement unit (sensor) 31.
  • the calculated estimated temperature is output to the output unit 34.
  • the temperature data stored in the storage unit 32 after being measured by the measurement unit (sensor) 31 is read out (read) by the calculation unit 33.
  • the calculation formula is determined, the estimated temperature is calculated, and it is output to the output unit 34. As a result, it takes, for example, about 20 minutes from the measurement to the output of the estimated temperature.
  • the temperature measured by the measuring unit may be collectively stored in the storage unit, and then the temperature data may be read out (read) to calculate the estimated temperature.
  • the temperature measuring device according to the present embodiment may be attached to the user's body as an integral part of the wearable device.
  • the measuring unit (sensor) 31 is attached to the user's body as a wearable device, and the storage unit 32 and the calculation unit 33 are stored in a smartphone or server outside the wearable device. May be provided.
  • the temperature measuring device is provided with a transmission / reception unit for each of the wearable device and an external server, etc., and the measured temperature measured by the wearable device is transmitted to the server or the like, and is stored and calculated by the server or the like.
  • the estimated temperature and the like may be output to the server or the like, or may be transmitted to the wearable device or the like and output.
  • FIG. 6 shows a configuration example of the computer 60 in the temperature measuring device according to the embodiment of the present invention.
  • the temperature measuring device can be realized by a computer 60 including a CPU (Central Processing Unit) 63, a storage device (storage unit) 62, and an interface device 61, and a program for controlling these hardware resources.
  • the measurement unit and the output unit are connected to the interface device.
  • the CPU executes the process according to the embodiment of the present invention according to the temperature measurement program stored in the storage device. In this way, the temperature measuring program makes the temperature measuring device work.
  • a computer may be provided inside the device, or at least one part of the functions of the computer may be realized by using an external computer.
  • the storage unit may also use the storage medium 64 outside the apparatus, or may read out and execute the temperature measurement program stored in the storage medium 64.
  • the storage medium 64 includes various magnetic recording media, optical magnetic recording media, CD-ROMs, CD-Rs, and various memories. Further, the temperature measurement program may be supplied to the computer via a communication line such as the Internet.
  • the temperature inside the living body can be measured non-invasively and accurately.
  • the present invention can be applied to a deep thermometer used for body temperature control of workers, athletes and the like.
  • Temperature measuring device 31 Measuring unit (sensor) 32 Storage unit 321 Temperature storage unit 322 Estimated temperature storage unit 33 Calculation unit 331 Calculation unit 332 Comparison unit 34 Output unit

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Abstract

La présente invention concerne un procédé de mesure de température avec lequel la température à l'intérieur d'un corps vivant est mesurée sur la base de la température détectée au moyen d'un capteur (31), une température estimée pour la température à l'intérieur du corps vivant étant calculée, dans le capteur (31), au moyen d'une première formule, qui est basée sur un flux thermique calculé sur la base de la différence entre la température au niveau d'un site à proximité du corps vivant et la température au niveau d'un autre site, ou au moyen d'une seconde formule, qui corrige la température estimée calculée au moyen de la première formule ; la différence entre une première température estimée à un premier instant, qui précède l'instant auquel la dérivée temporelle du flux de chaleur dépasse une valeur de référence, et une deuxième température estimée calculée au moyen de la première formule à un second instant, qui suit l'instant auquel la dérivée temporelle du flux de chaleur dépasse la valeur de référence, et la différence entre la première température estimée et une troisième température estimée calculée au moyen de la seconde formule au second instant étant calculées ; et la formule permettant de calculer la température estimée étant déterminée comme étant la première formule ou la seconde formule sur la base des deux différences.　En conséquence, le procédé de mesure de température selon la présente invention permet de mesurer avec précision la température à l'intérieur d'un corps vivant d'une manière non invasive.
PCT/JP2020/027224 2020-07-13 2020-07-13 Dispositif, procédé et programme de mesure de température WO2022013911A1 (fr)

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JP2022535991A JP7464124B2 (ja) 2020-07-13 2020-07-13 温度測定装置、方法およびプログラム
PCT/JP2020/027224 WO2022013911A1 (fr) 2020-07-13 2020-07-13 Dispositif, procédé et programme de mesure de température

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019026439A1 (fr) * 2017-07-31 2019-02-07 帝人株式会社 Système d'estimation de la température profonde du corps, système d'avertissement de stress thermique et procédé d'estimation de la température profonde du corps
JP2019097819A (ja) * 2017-11-30 2019-06-24 株式会社テクノ・コモンズ 生体データ測定装置
WO2019129469A1 (fr) * 2017-12-29 2019-07-04 Medectis Ip Ltd. Technique non invasive pour la détermination de la température centrale d'un corps
JP2020008521A (ja) * 2018-07-12 2020-01-16 オリンパス株式会社 温度計測装置および温度計測方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019026439A1 (fr) * 2017-07-31 2019-02-07 帝人株式会社 Système d'estimation de la température profonde du corps, système d'avertissement de stress thermique et procédé d'estimation de la température profonde du corps
JP2019097819A (ja) * 2017-11-30 2019-06-24 株式会社テクノ・コモンズ 生体データ測定装置
WO2019129469A1 (fr) * 2017-12-29 2019-07-04 Medectis Ip Ltd. Technique non invasive pour la détermination de la température centrale d'un corps
JP2020008521A (ja) * 2018-07-12 2020-01-16 オリンパス株式会社 温度計測装置および温度計測方法

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