WO2021260834A1 - Dispositif, procédé et programme de mesure de température - Google Patents

Dispositif, procédé et programme de mesure de température Download PDF

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Publication number
WO2021260834A1
WO2021260834A1 PCT/JP2020/024784 JP2020024784W WO2021260834A1 WO 2021260834 A1 WO2021260834 A1 WO 2021260834A1 JP 2020024784 W JP2020024784 W JP 2020024784W WO 2021260834 A1 WO2021260834 A1 WO 2021260834A1
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temperature
living body
estimated
sensor
time
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PCT/JP2020/024784
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English (en)
Japanese (ja)
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雄次郎 田中
大地 松永
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日本電信電話株式会社
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Priority to PCT/JP2020/024784 priority Critical patent/WO2021260834A1/fr
Priority to JP2022531309A priority patent/JP7375933B2/ja
Publication of WO2021260834A1 publication Critical patent/WO2021260834A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K7/00—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements

Definitions

  • the present invention relates to a temperature measuring device, method and program for non-invasively and accurately measuring the temperature inside a living body.
  • Patent Document 1 Japanese Unexamined Patent Publication No. 2020-003291
  • sensor thermometer elements
  • pseudo-outside air a technique for estimating the core body temperature of a living body by assuming a one-dimensional model.
  • FIG. 9 shows a schematic diagram of a pseudo one-dimensional model for measuring the temperature inside the living body 91.
  • the temperature Tcbt inside the object to be measured (living body) 91 is the surface side (the surface in contact with the object) of the sensor 92 when an object (sensor) having a thermal resistance Rs is placed on the surface of the object to be measured (living body) 91. It can be estimated by using the equation (1) from the temperature Ts of the above and the temperature Tt on the back surface (the surface in contact with the outside air) side of the sensor 92.
  • Tcbt Ts + Rb x Hso (1)
  • FIG. 10 shows a comparison between the true internal temperature 101 and the estimated temperature 102 when the wind is blown by a fan.
  • the difference (error) between the true internal temperature 101 and the estimated temperature 102 is that when the wind exceeds a certain threshold, the heat transport mode changes from heat conduction to convection heat transfer, and the amount of heat transferred to the outside is Due to major changes.
  • the temperature measuring method is a temperature measuring method in which the temperature inside the living body is measured based on the temperature detected by the sensor, and the above-mentioned sensor is used.
  • the first temperature is measured by the first thermometer element arranged near the surface in contact with the living body
  • the second temperature is measured by the second thermometer element arranged at a position away from the first thermometer element.
  • a step of correcting the first estimated temperature and calculating a second estimated temperature by using a time constant depending on the heat capacity of the living body is provided.
  • the temperature measuring device is a temperature measuring device that measures the temperature inside the living body based on the temperature detected by the sensor, and is the first temperature measuring device arranged in the vicinity of the surface in contact with the living body.
  • a thermometer element and a second thermometer element arranged at a position away from the first thermometer element are provided, the first temperature is detected by the first thermometer element, and the second temperature is detected.
  • the first estimated temperature is calculated using the heat resistance of the living body and the heat resistance of the sensor, the heat flux is calculated based on the difference between the first temperature and the second temperature, and the heat flow is calculated.
  • the convection period is detected by the time differentiation of the bundle, and the first estimated temperature is corrected by using the time constant depending on the heat capacity of the sensor and the time constant depending on the heat capacity of the living body, and the second It is equipped with a calculation unit that calculates the estimated temperature.
  • the temperature measurement program according to the present invention is arranged in the vicinity of the surface of the sensor in contact with the living body with respect to the temperature measuring device that measures the temperature inside the living body based on the temperature detected by the sensor.
  • the present invention it is possible to provide a temperature measuring device, a method and a program for non-invasively and accurately measuring the temperature inside a living body.
  • FIG. 1 is a schematic diagram of a change with time of temperature for explaining the temperature measuring method according to the first embodiment of the present invention.
  • FIG. 2 is a diagram showing a change over time in the time derivative of the heat flux for explaining the temperature measuring method according to the first embodiment of the present invention.
  • FIG. 3 is a block diagram showing a configuration of a temperature measuring device according to the first embodiment of the present invention.
  • FIG. 4 is a flowchart of the temperature measuring method according to the first embodiment of the present invention.
  • FIG. 5 is a diagram showing changes over time in the deep temperature measured by the temperature measuring device and method according to the first embodiment of the present invention.
  • FIG. 6 is a diagram showing changes over time in the deep temperature measured by the temperature measuring device and method according to the first embodiment of the present invention.
  • FIG. 1 is a schematic diagram of a change with time of temperature for explaining the temperature measuring method according to the first embodiment of the present invention.
  • FIG. 2 is a diagram showing a change over time in the time derivative of the heat flux
  • FIG. 7 is a diagram showing changes over time in the deep temperature measured by the temperature measuring device and method according to the first embodiment of the present invention.
  • FIG. 8 is a diagram showing a configuration example of a computer according to an embodiment of the present invention.
  • FIG. 9 is a schematic diagram of a pseudo one-dimensional model in the conventional temperature measurement inside the living body.
  • FIG. 10 is a diagram showing changes over time in the deep temperature measured by the conventional method.
  • FIG. 1 is a schematic diagram of a change over time in temperature for explaining the method according to the present embodiment.
  • FIG. 1 is based on FIG. 10 described above, and shows a temperature change when a wind is applied.
  • the solid line 11 shows the true internal temperature
  • the dotted line 12 shows the estimated temperature.
  • the heat transport mode changes at t_bottom 1, and the estimated temperature 12 shows the maximum value at t_peak 1 (region 13).
  • the temperature change of the estimated temperature 12 is due to the heat capacity of the sensor.
  • the estimated temperature 12 decreases (region 14).
  • the temperature change of the estimated temperature 12 is due to the heat capacity of the living body.
  • the heat transport mode changes due to the stoppage of the wind, and the estimated temperature 12 shows the minimum value at t_peak2 (region 15).
  • the temperature change of the estimated temperature 12 is due to the heat capacity of the sensor.
  • the estimated temperature 12 rises (region 16).
  • the temperature change of the estimated temperature 12 is due to the heat capacity of the living body.
  • the change in the heat transport mode is detected by using the time derivative dHs of the heat flux Hs, and the error at the estimated temperature 12 is corrected.
  • FIG. 2 shows the time derivative dHs of the heat flux Hs in the time course of the temperature shown in FIG. Unlike the change in the estimated temperature, the time derivative dHs changes sharply when the heat transport mode changes and expresses steep peaks 21 and 22, so that it becomes easy to specify the time.
  • the time derivative dHs exceeds a predetermined reference value (threshold)
  • a predetermined reference value threshold
  • the reference value threshold value
  • the error temperature Terra when the heat transport mode changes changes with the equation (2) in the regions 14 and 16 and in the equation (3) in the regions 13 and 15 with respect to the time t.
  • the error temperature Terrar shown in the equation (2) is caused by the heat capacity of the living body, and ⁇ 1 is the time constant of the temperature change of the living body.
  • the error temperature Terrar shown in the equation (3) is due to the heat capacity of the sensor, and ⁇ 2 is the time constant of the temperature change of the sensor.
  • the temperature correction amount Tgap is the difference between the temperature Test_peak at the time t_peak where the error temperature peaks and the temperature Test_bottom at the time t_bottom immediately before the heat transport mode changes.
  • the corrected estimated temperature (first estimated temperature) is obtained by subtracting the transiently generated error temperature represented by the equations (2) and (3) from the estimated temperature (first estimated temperature) calculated by the equation (1).
  • the estimated temperature of 2) can be calculated to reduce the measurement error at the estimated temperature.
  • the heat flow Hs flows not only to the sensor but also to the outside of the sensor, so that the thermal resistance Rb of the living body changes. Therefore, by calibrating Rb according to the change in thermal resistance Rb during convection, the error in the estimated temperature in the convection state can be further reduced.
  • FIG. 3 shows a block diagram of the configuration of the temperature measuring device 30 according to the present embodiment.
  • the temperature measuring device 30 includes a measuring unit (sensor) 31, a storage unit 32, a calculation unit 33, and an output unit 34.
  • the measuring unit (sensor) 31 is arranged near the surface of the object to be measured (for example, a living body) in contact with the surface, and measures the temperature Ts (first temperature) near the surface of the measuring unit (sensor) 31.
  • the thermometer element 1 and the second thermometer element for measuring the temperature Tt (second temperature) on the back surface of the measuring unit 31 are provided.
  • the place where the temperature Tt is measured is not limited to the back surface of the measuring unit 31, and may be a position where the temperature Ts is measured, that is, a position away from the first thermometer element.
  • the second thermometer element may be arranged at a position far enough away from the first temperature and the second temperature so that the heat flux can be accurately calculated.
  • thermometer elements are used, but the number is not limited to two and may be plural. It is possible to measure the heat flux more accurately by using a plurality of thermometer elements.
  • the storage unit 32 stores the measurement time and the measurement temperature measured by the measurement unit 31.
  • the calculation unit 33 calculates the estimated temperature by using the measurement time and the measurement temperature measured by the measurement unit 31 and the measurement time and the measurement temperature read from the storage unit 32, and also calculates and estimates the error temperature. Correct the temperature.
  • the output unit 34 outputs (displays) the estimated temperature or the corrected estimated temperature.
  • the accurate temperature cannot be output, it is possible to output (display) a blank (state in which nothing is displayed) or the inability to measure the accurate temperature.
  • FIG. 4 shows a flowchart of the temperature measuring method according to the present embodiment.
  • the estimated temperature Test (first estimated temperature)
  • the estimated temperature test inside the living body when the temperature is measured by the sensor in contact with the surface of the living body is expressed by the following formula.
  • Test Ts + Rb ⁇ Hso
  • Ts is the surface temperature of the sensor (the temperature of the part in contact with the living body, the first temperature), and Rb is the thermal resistance of the living body.
  • Hso is a heat flux and is expressed by the following equation.
  • Tt is the temperature on the back surface of the sensor (the temperature of the portion in contact with the outside air, the second temperature), and Rs is the thermal resistance of the sensor.
  • A is a temperature estimation proportional coefficient parameter.
  • the temperature rises sharply at the beginning when the wind is applied, has an error peak, and then gradually falls.
  • the temperature drops sharply, has an error peak, and then rises.
  • Ts and Tt are measured by a sensor (step 401).
  • the estimated temperature Test (first estimated temperature) is calculated based on the equation (4) (step 402).
  • the time derivative dHs of the temperature change is calculated (step 403), and the change in the heat transport mode accompanying the start of convection is detected from the peak of dHs (step 404).
  • the estimated temperature is corrected as follows.
  • the biological time constant parameter ⁇ 1 and the sensor time constant parameter ⁇ 2 determine the response speed of the correction, and depend on the heat capacity and size of the living body and the sensor.
  • the object (measuring part) placed on the surface of the living body is a cylinder made of plastic, styrofoam, or the like and having a large cavity inside, for example, a cylinder having a diameter of about 30 mm and a height of about 5 mm, ⁇ 1 Is effective in the range of 1 to 10 minutes, and ⁇ 2 is effective in the range of about 10 seconds to 3 minutes.
  • the error peak detection time t_peak1 and the error peak temperature T_peak1 are detected with the time when the temperature change decreases from the increase as the maximum error peak value (step 405).
  • the temperature rise time t_bottom1 is detected by going back to the peak search time t_span from the time of detecting the change in dHs ( Step 406).
  • this time is the minimum value of the error peak, and the temperature at this time is T_bottom1.
  • the peak search time t_span is preferably about the time constant parameter of the sensor, for example, about 10 seconds.
  • Tgap1 T_peak1-T_bottom1.
  • the estimated temperature (first estimated temperature) Test from t_bottom1 to t_bottom2 (described later) is corrected by the equation (7), and the corrected estimated temperature (second estimated temperature). Calculate Test_correct (step 409).
  • Test_direct Test-Terror1 (7)
  • the error peak detection time t_peak2 and the error peak temperature T_peak2 are detected with the time when the temperature change decreases from the increase as the minimum error peak value (step 411).
  • the temperature rise time t_bottom2 is detected by going back to the peak search time t_span from the time of detecting the change in dHs.
  • this time is the maximum value of the error peak 2
  • the temperature at this time is T_bottom 2 (step 412).
  • Tgap2 T_peak2-T_bottom2.
  • the estimated temperature (first estimated temperature) Test after t_bottom2 is corrected by the equation (10), and the corrected estimated temperature (second estimated temperature) Test_collect is calculated (step 415). ).
  • the temperatures Ts and Tt are measured by a sensor (step 401).
  • the measurement time is t [i].
  • Test Ts + (A + ⁇ A) x Hs (4)'
  • A is a temperature estimation proportional coefficient parameter, which is a coefficient for correcting the influence of heat flux Hs when estimating the temperature, and the initial value may be 0.
  • this estimated temperature Test is output (displayed).
  • dHs [i] Hs [i] -Hs [i-1] (step 403).
  • the calculated dHs [i] is compared with the convection detection threshold dHs_thres to determine whether or not the form of heat transfer has changed due to convection (step 404).
  • the convection detection threshold dHs_thres is, for example, 0.02 ° C./sec.
  • step 404 when the condition of the determination in step 404 is not satisfied, it is determined that the form of heat transfer has not changed due to convection, no correction is performed, and the above-mentioned Test is set to the estimated temperature at time t [i]. Make a decision and continue to make measurements at the next time.
  • the correction temperature Terror is calculated as follows (steps 405 to 507).
  • Tgap in the equations (2) and (3) is calculated.
  • Tgap is the difference between the temperature Test_peak at the time t_peak where the error peaks and the temperature Test_bottom at the time t_bottom immediately before the heat transport mode changes.
  • step 405 the error peak of the temperature change is detected (step 405). As shown in FIG. 2, when the heat transport mode changes with the start of convection, an upwardly convex peak is shown.
  • the estimated temperature Test [i] at the current time t [i] and the estimated temperature Test [i-1] at the time t [i-1] are compared, and the temperature rise is changed to the temperature fall as a reference. Detect the error peak of temperature change. In this way, the difference in the first estimated temperature between adjacent times is calculated to detect the temperature of the error peak.
  • Test [i] is Test [i-1] or higher, the measurement is continuously executed.
  • the time when the test shows the minimum value that is, the time when the base of the error peak is shown is t_bottom1, and the temperature is set. It is set to Test_bottom1 (step 406).
  • the error temperature Terror1 used for correcting the estimated temperature (from t_bottom1 to t_peak1) before t_peak1 is calculated by the equation (5) (step 407).
  • the error temperature Terrar1 used for correcting the estimated temperature after t_peak1 is calculated by the equation (6) (step 408).
  • the estimated temperature from t_bottom1 to t_bottom2 is corrected by the equation (7), and the corrected estimated temperature (second estimated temperature) Test_correct is calculated (step 409).
  • the correction temperature Terrar is calculated as follows (steps 411 to 413).
  • the error peak of the temperature change is detected (step 411). As shown in FIG. 2, when the heat transport mode changes with the end of convection, a downwardly convex peak is shown.
  • the estimated temperature Test [i] at the current time t [i] and the estimated temperature Test [i-1] at the time t [i-1] are compared, and the temperature decreases to the temperature rise as a reference. Detect the error peak of temperature change. In this way, the difference in the first estimated temperature between adjacent times is calculated to detect the temperature of the error peak.
  • Test [i] is Test [i-1] or less
  • the measurement is continuously executed.
  • Test [i]> Test [i-1] the time t [i-1] is set to the error peak detection time t_peak2, and the temperature Test [i-1] at the same time is set to the error peak temperature Test_peak2.
  • the time when the test shows the maximum value that is, the time when the base of the error peak is shown is t_bottom2, and the temperature is set. It is set to Test_bottom2 (step 412).
  • Tgap2 Test_peak2-Test_bottom2.
  • the error temperature used for correcting the estimated temperature before t_peak2 (from t_bottom2 to t_peak2) is calculated by the equation (8) (step 413).
  • the error temperature Terror2 used for correcting the estimated temperature after t_peak2 is calculated by the equation (9) (step 414).
  • the estimated temperature Terror2 after t_bottom2 is corrected by the equation (10), and the corrected estimated temperature (second estimated temperature) Test_rect is calculated (step 415).
  • Second correction temperature it is determined whether or not the condition for calibrating the temperature estimation proportional coefficient parameter A is satisfied.
  • the initial calibration data number Calib_num is the number of measurements until the sensor operation stabilizes, and is, for example, 20 times.
  • the reference temperature Tcbt is used by measuring, for example, the eardrum temperature of the user (measured person) in advance.
  • the threshold value for determining the presence / absence of calibration, Thres_calib be about the target measurement accuracy, and for example, in the case of core body temperature, it may be about 0.1 ° C.
  • the temperature estimation proportional coefficient parameter A is calibrated by the equation (11), and the process from measurement to correction is subsequently executed.
  • the correction is completed when the Terrar reaches a predetermined temperature, for example, 0.01 ° C or less, and the estimated temperature without correction is output (displayed) thereafter.
  • the change in dHs is measured as an absolute value
  • the convection start and convection end that is, the convection period are detected in the order in which the change in the form of heat conduction is detected. For example, when convection does not occur at the start of measurement, the change in heat conduction morphology with the start of convection is detected first, and then the change in heat conduction morphology with the end of convection is detected. As an example, an example of detecting the convection period is shown.
  • the detection of the convection period is not limited to this, and the convection period can be detected by measuring the change in dHs positively or negatively. For example, when the change in dHs is 0 or more, the change in the morphology of heat conduction accompanying the start of convection is detected, and when the change in dHs is less than 0, the change in the morphology of heat conduction accompanying the end of convection is detected. , The convection period can be detected.
  • the estimated temperature calculated by the calculation unit 33 sequentially based on the temperature measured by the measurement unit (sensor) 31 is output to the output unit 34. ..
  • the temperature data stored in the storage unit 32 after being measured by the measurement unit (sensor) 31 is read out by the calculation unit 33 (read), and the estimated temperature is corrected.
  • the estimated temperature of 2 is calculated and output to the output unit 34. As a result, it takes, for example, about 20 minutes from the measurement to the output of the second estimated temperature.
  • the temperature measured by the measuring unit may be collectively stored in the storage unit, and then the temperature data may be read out (read) to calculate the estimated temperature.
  • FIGS. 5 to 7 show changes in body temperature when the core body temperature is measured while the wind of a fan is directly applied to the sensor unit.
  • first estimated temperature the estimated temperature without correction
  • corrected estimated temperature the corrected estimated temperature of the temperature measuring method according to the present embodiment
  • Figure 5 shows the change in body temperature when the wind is applied intermittently every 5 minutes.
  • the deep temperature 51 increases with the passage of time.
  • the uncorrected estimated temperature (first estimated temperature) 52 a peak indicating an increase or decrease in temperature with an intermittent wind is observed.
  • the corrected estimated temperature (second estimated temperature) 53 increases in almost the same manner as the deep temperature 51, and no peak indicating an increase or decrease in temperature due to the intermittent wind is observed.
  • FIGS. 6 and 7 show changes in body temperature when the wind is continuously applied for about 1 hour.
  • the deep temperature 61, 71 increases / decreases when the wind is applied (started) and when the wind stops.
  • the error (difference from the deep temperature) in the corrected estimated temperature (second estimated temperature) is reduced to ⁇ 0.1 ° C or less. This is because the transient error caused by the occurrence and termination of convection and the error caused by the occurrence of convection have been reduced.
  • the fact that the corrected estimated temperature (second estimated temperature) is almost the same as the deep temperature 51 indicates that the temperature inside the living body can be measured with high accuracy by the temperature measuring method according to the present embodiment. ing.
  • the temperature inside the living body can be measured with high accuracy.
  • the temperature measuring device according to the present embodiment may be attached to the user's body as an integral part of the wearable device.
  • the measuring unit (sensor) 31 is attached to the user's body as a wearable device, and the storage unit 32 and the calculation unit 33 are stored in a smartphone or server outside the wearable device. May be provided.
  • the temperature measuring device is provided with a transmission / reception unit for each of the wearable device and an external server, etc., and the measured temperature measured by the wearable device is transmitted to the server or the like, and is stored and calculated by the server or the like.
  • the estimated temperature and the like may be output to the server or the like, or may be transmitted to the wearable device or the like and output.
  • FIG. 8 shows a configuration example of a computer in the temperature measuring device according to the embodiment of the present invention.
  • the temperature measuring device can be realized by a computer including a CPU (Central Processing Unit), a storage device (storage unit), and an interface device, and a program for controlling these hardware resources.
  • the measurement unit and the output unit are connected to the interface device.
  • the CPU executes the process according to the embodiment of the present invention according to the temperature measurement program stored in the storage device. In this way, the temperature measurement program makes the temperature measurement device work.
  • a computer may be provided inside the device, or at least one part of the functions of the computer may be realized by using an external computer.
  • the storage unit may also use a storage medium outside the device, or may read out and execute the temperature measurement program stored in the storage medium.
  • the storage medium includes various magnetic recording media, optical magnetic recording media, CD-ROMs, CD-Rs, and various memories.
  • the temperature measurement program may be supplied to the computer via a communication line such as the Internet.
  • the present invention can be applied to a deep thermometer used for body temperature control of workers, athletes and the like.

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Abstract

Un procédé de mesure de température selon la présente invention est un procédé de mesure de température qui mesure la température interne d'un organisme vivant sur la base d'une température détectée par un capteur, ledit procédé comprenant : une étape consistant à, dans le capteur, mesurer une première température par l'intermédiaire d'un premier élément thermomètre disposé près d'une surface qui est en contact avec l'organisme vivant, et mesurer une seconde température par l'intermédiaire d'un second élément thermomètre disposé à une position séparée du premier élément thermomètre ; une étape consistant à utiliser la première température, la seconde température, la résistance thermique de l'organisme vivant et la résistance thermique du capteur pour calculer une première température estimée ; une étape consistant à calculer un flux de chaleur sur la base de la différence entre la première température et la seconde température ; une étape consistant à détecter une période de convection en utilisant la dérivée temporelle du flux de chaleur ; et une étape consistant à utiliser une constante de temps dépendant de la capacité thermique du capteur et une constante de temps dépendant de la capacité thermique de l'organisme vivant pour corriger la première température estimée et calculer une seconde température estimée.　En conséquence, le procédé de mesure de température selon la présente invention est apte à mesurer avec précision la température à l'intérieur d'un organisme vivant d'une manière non invasive.
PCT/JP2020/024784 2020-06-24 2020-06-24 Dispositif, procédé et programme de mesure de température WO2021260834A1 (fr)

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JP2022531309A JP7375933B2 (ja) 2020-06-24 2020-06-24 温度測定装置、方法およびプログラム

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019012027A (ja) * 2017-06-30 2019-01-24 株式会社テクノ・コモンズ 生体データ測定装置
WO2019020439A1 (fr) * 2017-07-25 2019-01-31 Telefonaktiebolaget Lm Ericsson (Publ) Identifiant caché d'abonnement
WO2019129469A1 (fr) * 2017-12-29 2019-07-04 Medectis Ip Ltd. Technique non invasive pour la détermination de la température centrale d'un corps

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7073919B2 (ja) 2018-06-01 2022-05-24 日本電信電話株式会社 生体内温度測定装置および生体内温度測定方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019012027A (ja) * 2017-06-30 2019-01-24 株式会社テクノ・コモンズ 生体データ測定装置
WO2019020439A1 (fr) * 2017-07-25 2019-01-31 Telefonaktiebolaget Lm Ericsson (Publ) Identifiant caché d'abonnement
WO2019129469A1 (fr) * 2017-12-29 2019-07-04 Medectis Ip Ltd. Technique non invasive pour la détermination de la température centrale d'un corps

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