WO2022009584A1 - 血液浄化装置 - Google Patents

血液浄化装置 Download PDF

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Publication number
WO2022009584A1
WO2022009584A1 PCT/JP2021/021637 JP2021021637W WO2022009584A1 WO 2022009584 A1 WO2022009584 A1 WO 2022009584A1 JP 2021021637 W JP2021021637 W JP 2021021637W WO 2022009584 A1 WO2022009584 A1 WO 2022009584A1
Authority
WO
WIPO (PCT)
Prior art keywords
dialysate
blood
circuit
air
filter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2021/021637
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
拓実 本間
和也 辻
輝 千秋
佑哉 毛受
邦彦 秋田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nikkiso Co Ltd
Original Assignee
Nikkiso Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nikkiso Co Ltd filed Critical Nikkiso Co Ltd
Priority to EP21837206.8A priority Critical patent/EP4180068A4/en
Priority to US18/014,772 priority patent/US12472290B2/en
Priority to CN202180048618.3A priority patent/CN115776901B/zh
Priority to CN202511927953.7A priority patent/CN121714797A/zh
Publication of WO2022009584A1 publication Critical patent/WO2022009584A1/ja
Anticipated expiration legal-status Critical
Priority to US19/358,667 priority patent/US20260034282A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A61M1/3644—Mode of operation
    • A61M1/3649—Mode of operation using dialysate as priming or rinsing liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A61M1/1603—Regulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A61M1/3644—Mode of operation
    • A61M1/3646—Expelling the residual body fluid after use, e.g. back to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A61M1/3644—Mode of operation
    • A61M1/365—Mode of operation through membranes, e.g. by inverted trans-membrane pressure [TMP]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A61M1/3644—Mode of operation
    • A61M1/3652—Mode of operation using gas, e.g. air

Definitions

  • the dialysate filter 11 purifies the dialysate by capturing substances such as endotoxin contained in the dialysate supplied from the dialysate supply unit 6.
  • the dialysate filter 11 is provided in the dialysate circuit 3 and includes a primary chamber 11a and a secondary chamber 11b. Further, the dialysate filter 11 is provided with a dialysate purifying membrane inside.
  • the dialysate purification membrane is composed of a bundle of hollow fibers (hollow fiber membranes) having holes in the side walls.
  • the dialysate filter 11 is configured to allow the dialysate to flow from the primary chamber 11a (inside the dialysate purification membrane) to the secondary chamber 11b (outside the dialysate purification membrane).
  • the dialysate filter 11 has a property of allowing water to pass through and preventing air from passing through due to the surface tension of water molecules.
  • FIG. 3 shows the flow of the dialysate when the back-filtration type blood return step is performed using the dialysate in the dialysate filter 10.
  • the blood in the reverse filtration type blood return step, the blood is returned to the body in the positive direction of the liquid feeding.
  • the on-off valves V1-6, 7c, and 8c
  • the on-off valve shown in the figure is shaded, and when the on-off valve is closed, the on-off valve shown in the figure is opened and closed.
  • the valve is shown in white.
  • the on-off valve 7c, the on-off valve V3, the on-off valve V4, and the on-off valve V2 are opened. Further, the air pump 7a rotates in the forward direction.
  • the opening of these on-off valves and the rotation of the air pump 7a are controlled by instructions from the control device 12.
  • the control device 12 controls the rotation speed of the air pump 7a per unit time so that the dialysate flows to the dialysate circuit 3 (dialysis fluid introduction circuit 3a) and the blood circuit 2. That is, the control device 12 controls the flow rate of air from the primary air introduction unit 7.
  • the on-off valve V10 shown in FIG. 2 is closed.
  • the above determination determines whether or not the dialysate flowing through the dialysate introduction circuit 3a has reached a predetermined amount (for example, the volume of the dialysate filter 10 (primary chamber 10a and secondary chamber 10b)). It may be done by.
  • a flow meter is provided in the dialysate introduction circuit 3a, and the flow meter detects the flow rate of the dialysate flowing through the dialysate introduction circuit 3a. The detected flow rate value is transmitted to the control device 12. The control device 12 determines whether or not the flow rate value has reached a predetermined amount.
  • the on-off valve 7c, the on-off valve V3, the on-off valve V4, and the on-off valve V1 are opened. Further, the air pump 7a rotates in the forward direction. Further, the blood pump 5 rotates in the reverse direction.
  • the opening of these on-off valves, the rotation of the air pump 7a, and the rotation of the blood pump 5 are controlled by instructions from the control device 12.
  • the control device 12 controls the rotation speed of the air pump 8a per unit time so that the dialysate flows to the dialysate circuit 3 (dialysis fluid introduction circuit 3a) and the blood circuit 2 (secondary air introduction). Control the flow rate of air in unit 8).
  • the on-off valve 14c, the on-off valve V3, the on-off valve V4, and the on-off valve V2 are opened. Further, the air pump 14a rotates in the forward direction.
  • the opening of these on-off valves and the rotation of the air pump 14a are controlled by instructions from the control device 12.
  • the control device 12 controls the rotation speed of the air pump 14a per unit time so that the dialysate flows to the dialysate circuit 3 (dialysis fluid introduction circuit 3a) and the blood circuit 2 (air introduction unit 14). Control the flow of air from).
  • the control device 12 In the reverse filtration type blood return step (forward direction of liquid feeding) described with reference to FIG. 10, at least the control device 12, the on-off valve 14c, the on-off valve V3, the on-off valve V4, the on-off valve V2, and the on-off valve V2 are supplied with power from the backup power supply 13. This is done by operating only the air pump 14a.
  • components such as the blood pump 5 and the compound pump 9 for flowing the dialysate to the dialysate circuit 3 and flowing the blood to the blood circuit 2 may be stopped in the dialysis treatment.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • External Artificial Organs (AREA)
PCT/JP2021/021637 2020-07-09 2021-06-07 血液浄化装置 Ceased WO2022009584A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP21837206.8A EP4180068A4 (en) 2020-07-09 2021-06-07 BLOOD PURIFICATION DEVICE
US18/014,772 US12472290B2 (en) 2020-07-09 2021-06-07 Blood purification apparatus
CN202180048618.3A CN115776901B (zh) 2020-07-09 2021-06-07 血液净化装置
CN202511927953.7A CN121714797A (zh) 2020-07-09 2021-06-07 血液净化装置
US19/358,667 US20260034282A1 (en) 2020-07-09 2025-10-15 Blood Purification Apparatus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020-118794 2020-07-09
JP2020118794A JP7737222B2 (ja) 2020-07-09 2020-07-09 血液浄化装置

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US18/014,772 A-371-Of-International US12472290B2 (en) 2020-07-09 2021-06-07 Blood purification apparatus
US19/358,667 Continuation US20260034282A1 (en) 2020-07-09 2025-10-15 Blood Purification Apparatus

Publications (1)

Publication Number Publication Date
WO2022009584A1 true WO2022009584A1 (ja) 2022-01-13

Family

ID=79552387

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2021/021637 Ceased WO2022009584A1 (ja) 2020-07-09 2021-06-07 血液浄化装置

Country Status (5)

Country Link
US (2) US12472290B2 (https=)
EP (1) EP4180068A4 (https=)
JP (2) JP7737222B2 (https=)
CN (2) CN121714797A (https=)
WO (1) WO2022009584A1 (https=)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007215746A (ja) * 2006-02-16 2007-08-30 Nikkiso Co Ltd 血液浄化装置及びそのリーク検査方法
JP2012005721A (ja) * 2010-06-25 2012-01-12 Nipro Corp 返血方法および血液浄化装置
JP2012034782A (ja) * 2010-08-05 2012-02-23 Nikkiso Co Ltd 血液浄化装置及びその返血方法
JP2013106976A (ja) * 2013-03-05 2013-06-06 Nikkiso Co Ltd 血液浄化装置
JP2017023441A (ja) * 2015-07-23 2017-02-02 日機装株式会社 血液浄化装置
JP2018139791A (ja) * 2017-02-27 2018-09-13 川澄化学工業株式会社 血液浄化装置、及び、血液浄化方法
JP2019088919A (ja) * 2013-03-15 2019-06-13 デカ・プロダクツ・リミテッド・パートナーシップ 血液処置システムおよび方法

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US6264680B1 (en) * 1998-01-23 2001-07-24 Viacirq, Inc. Apparatuses and processes for whole-body hyperthermia
CA2682544C (en) * 2007-03-30 2012-09-25 Jms Co., Ltd. Blood circuit, blood purification control apparatus, and priming method
WO2008152810A1 (ja) * 2007-06-13 2008-12-18 Kuraray Medical Inc. 血液浄化装置およびその回路接続不良の確認方法
JP5220171B2 (ja) * 2011-08-17 2013-06-26 日機装株式会社 血液浄化装置
CN104379186B (zh) * 2012-08-09 2016-05-04 日机装株式会社 血液净化装置及其预充方法
JP5986258B1 (ja) * 2015-04-20 2016-09-06 日機装株式会社 血液浄化装置
JP6011701B2 (ja) * 2015-09-24 2016-10-19 ニプロ株式会社 透析装置
JP6933439B2 (ja) * 2015-10-21 2021-09-08 日機装株式会社 血液浄化装置
JP6636770B2 (ja) * 2015-10-30 2020-01-29 日機装株式会社 血液浄化装置
CN109069723B (zh) * 2016-03-31 2021-09-17 旭化成医疗株式会社 血液净化系统和其启动加注方法
JP2018094052A (ja) * 2016-12-13 2018-06-21 川澄化学工業株式会社 血液浄化装置の気密試験方法
US10960119B2 (en) * 2017-05-03 2021-03-30 Fresenius Medical Care Deutschland Gmbh Method for operating a blood treatment apparatus, control unit and treatment apparatus for executing the method

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007215746A (ja) * 2006-02-16 2007-08-30 Nikkiso Co Ltd 血液浄化装置及びそのリーク検査方法
JP2012005721A (ja) * 2010-06-25 2012-01-12 Nipro Corp 返血方法および血液浄化装置
JP2012034782A (ja) * 2010-08-05 2012-02-23 Nikkiso Co Ltd 血液浄化装置及びその返血方法
JP5693890B2 (ja) 2010-08-05 2015-04-01 日機装株式会社 血液浄化装置
JP2013106976A (ja) * 2013-03-05 2013-06-06 Nikkiso Co Ltd 血液浄化装置
JP2019088919A (ja) * 2013-03-15 2019-06-13 デカ・プロダクツ・リミテッド・パートナーシップ 血液処置システムおよび方法
JP2017023441A (ja) * 2015-07-23 2017-02-02 日機装株式会社 血液浄化装置
JP2018139791A (ja) * 2017-02-27 2018-09-13 川澄化学工業株式会社 血液浄化装置、及び、血液浄化方法

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Title
See also references of EP4180068A4

Also Published As

Publication number Publication date
JP2025176075A (ja) 2025-12-03
EP4180068A4 (en) 2023-12-20
JP2022015749A (ja) 2022-01-21
JP7737222B2 (ja) 2025-09-10
CN121714797A (zh) 2026-03-24
US20240238491A1 (en) 2024-07-18
US12472290B2 (en) 2025-11-18
CN115776901B (zh) 2026-01-09
US20260034282A1 (en) 2026-02-05
CN115776901A (zh) 2023-03-10
EP4180068A1 (en) 2023-05-17

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