WO2022004770A1 - Modèle de vaisseau sanguin et procédé d'évaluation de corps long médical - Google Patents

Modèle de vaisseau sanguin et procédé d'évaluation de corps long médical Download PDF

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WO2022004770A1
WO2022004770A1 PCT/JP2021/024687 JP2021024687W WO2022004770A1 WO 2022004770 A1 WO2022004770 A1 WO 2022004770A1 JP 2021024687 W JP2021024687 W JP 2021024687W WO 2022004770 A1 WO2022004770 A1 WO 2022004770A1
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Prior art keywords
passage
branch
blood vessel
main
main passage
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PCT/JP2021/024687
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English (en)
Japanese (ja)
Inventor
健一 堀場
春佳 杉村
大 冨田
春佳 浅見
理樹 影山
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テルモ株式会社
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Priority to JP2022534071A priority Critical patent/JPWO2022004770A1/ja
Publication of WO2022004770A1 publication Critical patent/WO2022004770A1/fr

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    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B9/00—Simulators for teaching or training purposes

Definitions

  • the present invention relates to a blood vessel model simulating a blood vessel and a method for evaluating a medical long body using the blood vessel model.
  • Patent Document 1 describes a blood vessel model used for testing the operational performance of a medical long body.
  • a microcatheter or a small bifurcated blood vessel that branches from a large main blood vessel to a sharp turn is used. It may be difficult to select because it is selected by the guide wire.
  • the main blood vessel is thick, the microcatheter is easily bent, so that it is difficult to enter the bifurcated blood vessel, or even if it enters, the tip of the microcatheter may come off.
  • the tip of the microcatheter easily comes out of the bifurcated blood vessel, which makes selection more difficult.
  • the inner diameter of the internal iliac artery which is the main blood vessel, is about 2 to 8 mm, and the inner diameter of the bifurcated blood vessel is about 1 mm.
  • the inner diameter of the main blood vessel is about 2 to 5 mm
  • the inner diameter of the bifurcated blood vessel is about 1 mm
  • the bifurcation may be continuous. If the branch is further continuous from the bifurcated vessel, it becomes more difficult to select the bifurcated vessel with a microcatheter or a guide wire.
  • the present invention has been made to solve the above-mentioned problems, and is a vascular model capable of evaluating the selection performance of a medical long body for a bifurcated blood vessel that branches at a sharp angle so as to be folded back from the main blood vessel. And to provide a method for evaluating medical strips.
  • the blood vessel model according to the present invention that achieves the above object is a blood vessel model having a main passage simulating a main blood vessel and a branch passage thinner than the main passage simulating a branch blood vessel branching from the main blood vessel.
  • the branch angle of the branch passage with respect to the main passage is more than 0 degrees and less than 90 degrees when the case where the branch passage is folded back in the opposite direction to the main passage is defined as 0 degrees. It is characterized by.
  • the method for evaluating a medical elongated body according to the present invention is an evaluation method for a medical elongated body using a blood vessel model, which is a main passage simulating a main blood vessel and a branch from the main blood vessel. It has a branch passage thinner than the main passage by simulating a branch blood vessel, and the branch angle of the branch passage with respect to the main passage is a case where the branch passage is folded back in the opposite direction to the main passage.
  • a step of preparing a vascular model that is more than 0 degrees and less than 90 degrees when defined as 0 degrees, and the medical elongated body is inserted into the main passage and reached from the main passage to the branch passage. It is characterized by having a step of attempting to do so and a step of determining whether or not to reach the branch passage.
  • the vascular model configured as described above and the evaluation method for the medical elongate can evaluate the selection performance of the medical elongate for the bifurcated blood vessel that branches at an acute angle so as to be folded back from the main blood vessel. ..
  • the blood vessel model may have a plurality of branch passages having different branch angles with respect to the main passage. This makes it possible to evaluate the selection performance of medical long bodies in bifurcated blood vessels at various bifurcation angles with one blood vessel model.
  • the blood vessel model has a plurality of main passages having different inner diameters, and the branch passages branching from the main passages may be provided. As a result, multiple combinations of main passages and branch passages are provided, so one blood vessel model reproduces a branch blood vessel that branches at an acute angle so that it can be folded back from main blood vessels of various inner diameters, and is a medical long body. It is possible to evaluate the selection performance.
  • the inner diameters of the plurality of main passages having different inner diameters may be gradually decreased toward the peripheral side. This makes it possible to simulate the actual blood vessel diameter and make the blood vessel model compact.
  • the blood vessel model may have at least one peripheral bifurcation passage that branches on the peripheral side of the bifurcation passage away from the main passage. This makes it possible to evaluate the selection performance of a medical long body that continuously passes through a plurality of branches.
  • the blood vessel model has a plurality of branch passages having different branch angles with respect to the main passage, and at least one of the peripheral branch passages provided at the periphery of the branch passage may be another branch passage. ..
  • the peripheral branch passage provided at one periphery of the branch passage can be reproduced by the other branch passage, so that the blood vessel model can be realized compactly.
  • the main passage may be branched and provided in plurality.
  • a blood vessel model having a plurality of main passages can be realized compactly.
  • a plurality of branch passages in which a plurality of branch passages having different branch angles with respect to the main passage are arranged in the extending direction of the main passage may be provided at different positions in the circumferential direction of the main passage. This makes it possible to evaluate the selection performance of medical long bodies in various bifurcated blood vessels with one blood vessel model.
  • the blood vessel model 10 is a model simulating a blood vessel in order to evaluate the selectivity of a bifurcated blood vessel of a medical long body such as a microcatheter or a guide wire.
  • the use of the blood vessel model 10 is not limited to the use for evaluation of a medical long body, and may be used, for example, for training of a procedure.
  • the blood vessel model 10 includes two split simulation portions 11, two holding plates 12 sandwiching the split simulation portions 11, a plurality of connecting tools 13, and an insertion port 14. ing.
  • the two divided simulation units 11 are substantially rectangular flat plates in which a groove simulating a blood vessel is formed on the facing surface 15 side.
  • the two split simulated portions 11 are formed in a plane-symmetrical shape. Therefore, by overlapping on the facing surfaces 15, the grooves overlap, and a blood vessel simulating portion 20 simulating a blood vessel having a substantially circular cross section is formed.
  • the split simulated portion 11 is preferably transparent or translucent so that the inside can be visually recognized, and is preferably formed of a flexible material close to the actual living tissue.
  • the constituent material of the division simulation unit 11 is not particularly limited, and is, for example, a silicone resin, SEBS as various elastomer resins, a polyolefin elastomer, a polyamide elastomer, an acrylic elastomer, a fluoroelastomer, and the like.
  • the constituent material of the split simulated portion 11 is a silicone resin.
  • the division simulation unit 11 is well formed by using a mold, but the forming method is not particularly limited, and the division simulation unit 11 may be formed by, for example, a 3D printer.
  • the holding plate 12 is a member that sandwiches the two split simulated portions 11 in order to hold the two flexible split simulated portions 11 in an overlapping state.
  • Each holding plate 12 is a substantially rectangular flat plate capable of covering the divided simulated portion 11.
  • the holding plate 12 is preferably transparent or translucent so that the inside can be visually recognized, and is preferably formed of a hard material capable of holding the flexible split simulated portion 11.
  • the constituent material of the holding plate 12 is not particularly limited, and is, for example, acrylic resin, ABS resin, acrylic resin, methacrylic resin, polycarbonate, melamine resin, styrene resin, hard vinyl chloride resin, fluororesin, glass and the like.
  • the constituent material of the holding plate 12 is an acrylic resin.
  • the connector 13 is a member for holding the split simulated portion 11 sandwiched between the holding plates 12.
  • the connector 13 is composed of, for example, bolts and nuts capable of sandwiching the two holding plates 12 through the through holes formed in the split simulated portion 11 and the holding plate 12.
  • the configuration of the connector 13 is not particularly limited, and may be, for example, a clamp or the like.
  • the insertion port 14 is a site for inserting a medical long body into the blood vessel model 10.
  • the insertion port 14 is arranged in communication with the groove so as to be sandwiched between the opposite grooves on the side end faces of the two division simulated portions 11.
  • the insertion port 14 is composed of, for example, a hemostatic valve having a three-way stopcock, a Y connector, or the like.
  • the insertion port 14 is connected to a communication passage 21 described later of the blood vessel simulating unit 20 as a site for inserting a medical long body.
  • the insertion port 14 provided with a hemostatic valve or the like may be arranged at an opening other than the connecting passage 21 on the side end faces of the two split simulated portions 11. This makes it easy to fill the inside of the blood vessel simulating portion 20 with a liquid, and it is possible to maintain a good state of being filled with the liquid.
  • the blood vessel model 10 is a model having a substantially planar structure.
  • the plate thickness of the blood vessel model 10 having a substantially planar structure is 100 mm or less, preferably 50 mm or less, and more preferably 30 mm or less.
  • the blood vessel simulation unit 20 formed in the division simulation unit 11 includes a connecting passage 21 through which the insertion port 14 communicates, a plurality of main passages 30 simulating a main blood vessel, and a plurality of branch passages simulating a bifurcated blood vessel branching from the main blood vessel. 40 and an auxiliary passage 50 for bleeding air when filling the inside of the blood vessel simulating portion 20 with a liquid are provided.
  • the plurality of main passages 30 include a base end main passage 31 extending from the connecting passage 21, a first main passage 32 communicating with the base end main passage 31, and a second main passage 33 branching from the base end main passage 31. It has a third main passage 34 communicating with the second main passage 33 and a fourth main passage 35 communicating with the third main passage 34.
  • the base end main passage 31 extends linearly from the connecting passage 21.
  • the inner diameter of the base end main passage 31 is not particularly limited, but is, for example, 5 mm.
  • the first main passage 32 is located on the peripheral side of the proximal main passage 31 and extends linearly from the proximal main passage 31.
  • the first main passage 32 and the base end main passage 31 are arranged coaxially.
  • the inner diameter of the first main passage 32 is larger than the inner diameter of the base end main passage 31.
  • the inner diameter of the first main passage 32 is not particularly limited, but is, for example, 8 mm.
  • the peripheral side means the side away from the insertion port 14 (the side in the traveling direction of the medical long body to be inserted) in the passage.
  • the base end main passage 31 and the first main passage 32 are smoothly connected by expanding the inner diameter from the base end main passage 31 toward the first main passage 32 in a tapered shape.
  • the second main passage 33 is a passage that branches from the base end main passage 31 at a predetermined branch angle ⁇ .
  • the second main passage 33 extends linearly from the base end main passage 31.
  • the inner diameter of the second main passage 33 is equal to the inner diameter of the base end main passage 31.
  • the inner diameter of the second main passage 33 is not particularly limited, but is, for example, 5 mm.
  • the branch angle is the case where when the other passage branches from one passage extending to the peripheral side, the other passage is folded back to the opposite side (insertion port 14 side) on the peripheral side with respect to the one passage. Is defined as 0 degrees, and the case where the other passage extends in the same direction (peripheral side) with respect to one passage is defined as 180 degrees.
  • the third main passage 34 is located on the peripheral side of the second main passage 33 and extends linearly from the second main passage 33.
  • the third main passage 34 and the second main passage 33 are arranged coaxially.
  • the inner diameter of the third main passage 34 is smaller than the inner diameter of the second main passage 33.
  • the inner diameter of the third main passage 34 is not particularly limited, but is, for example, 2 mm.
  • the second main passage 33 and the third main passage 34 are smoothly connected by decreasing the inner diameter from the second main passage 33 toward the third main passage 34 in a tapered shape.
  • the fourth main passage 35 is located on the peripheral side of the third main passage 34 and extends linearly from the third main passage 34.
  • the fourth main passage 35 and the third main passage 34 are arranged coaxially.
  • the inner diameter of the fourth main passage 35 is smaller than the inner diameter of the third main passage 34.
  • the inner diameter of the fourth main passage 35 is not particularly limited, but is, for example, 1.2 mm.
  • a plurality of branch passages that line up in the extending direction of the main passage 30 and branch from the main passage 30 at different branch angles. 40 is connected.
  • the plurality of branch passages 40 have a first branch passage 41, a second branch passage 42, a third branch passage 43, and a fourth branch passage 44 that branch from the second main passage 33.
  • the first branch passage 41, the second branch passage 42, the third branch passage 43, and the fourth branch passage 44 are arranged toward the periphery along the extending direction of the second main passage 33, and branch from the second main passage 33. ing.
  • the axes of the first branch passage 41, the second branch passage 42, the third branch passage 43, and the fourth branch passage 44 are arranged on the same plane.
  • the first branch passage 41 branches from the second main passage 33 at a branch angle ⁇ 1.
  • the second branch passage 42 branches from the second main passage 33 on the peripheral side of the first branch passage 41 at a branch angle ⁇ 2.
  • the branch angle ⁇ 2 is larger than the branch angle ⁇ 1.
  • the third branch passage 43 branches from the second main passage 33 on the peripheral side of the second branch passage 42 at a branch angle ⁇ 3.
  • the branch angle ⁇ 3 is larger than the branch angle ⁇ 2.
  • the fourth branch passage 44 branches from the second main passage 33 on the peripheral side of the third branch passage 43 at a branch angle ⁇ 4.
  • the branch angle ⁇ 4 is larger than the branch angle ⁇ 3.
  • the branch angles ⁇ 1 to ⁇ 4 are more than 0 degrees and less than 90 degrees, preferably 30 degrees or more and 75 degrees or less.
  • the branch angle ⁇ 1 is 30 degrees
  • the branch angle ⁇ 2 is 45 degrees
  • the branch angle ⁇ 3 is 60 degrees
  • the branch angle ⁇ 4 is 75 degrees.
  • the branch passage 40 has a peripheral branch passage 45 that branches from the second branch passage 42, the third branch passage 43, and the fourth branch passage 44 at a branch angle ⁇ .
  • the branch angle ⁇ of the peripheral branch passage 45 is not particularly limited, but is more than 0 degrees and less than 90 degrees, for example, 75 degrees.
  • the peripheral branch passage 45 that branches from the second branch passage 42 is connected so as to communicate with the first branch passage 41. That is, the first branch passage 41 is also a second peripheral branch passage that further branches at the branch angle ⁇ from the peripheral branch passage 45 that branches from the second branch passage 42.
  • the peripheral branch passage 45 that branches from the third branch passage 43 is connected so as to communicate with the second branch passage 42. That is, the second branch passage 42 is also a second peripheral branch passage that further branches at the branch angle ⁇ from the peripheral branch passage 45 that branches from the third branch passage 43.
  • the peripheral branch passage 45 that branches from the fourth branch passage 44 is connected so as to communicate with the third branch passage 43. That is, the third branch passage 43 is also a second peripheral branch passage that further branches at the branch angle ⁇ from the peripheral branch passage 45 that branches from the fourth branch passage 44.
  • the branch angle ⁇ of the second peripheral branch passage is not particularly limited, but is more than 0 degrees and 90 degrees or less, for example, 90 degrees.
  • the inner diameter of the first branch passage 41, the second branch passage 42, the third branch passage 43, the fourth branch passage 44, and the peripheral branch passage 45 is larger than the inner diameter of the second main passage 33, which is the original main passage 30 of the branch. It is small, for example, 1 mm.
  • the branch passage 45 is branched.
  • the branch angles ⁇ 1 to ⁇ 4 of the branch passage 40 with respect to the third main passage 34 or the fourth main passage 35 are preferably the same as the branch angles ⁇ 1 to ⁇ 4 of the branch passage 40 with respect to the second main passage 33 described above, but they match. It doesn't have to be.
  • the branch angle ⁇ of the peripheral branch passage 45 branching on the peripheral side of the third main passage 34 or the fourth main passage 35 and the branch angle ⁇ of the second peripheral branch passage also branch on the peripheral side of the second main passage 33. It is preferable that it matches the branch angle ⁇ of the peripheral branch passage 45 and the branch angle ⁇ of the second peripheral branch passage, but it does not have to match.
  • two branch passage groups 46 including a second branch passage 42, a third branch passage 43, and a fourth branch passage 44 are branched.
  • the two branch passage groups 46 are connected in opposite directions in the circumferential direction of the first main passage 32. Therefore, the first main passage 32 and the two branch passage groups 46 are arranged on the same plane.
  • the tester performing the evaluation test determines the main passage 30 and the branch passage 40 into which the microcatheter 100 is inserted. For example, the tester decides to insert the microcatheter 100 from the first main passage 32 into one of the third branch passages 43, as shown in FIG.
  • the tester injects water, physiological saline, an aqueous solution containing a surfactant, or the like into the blood vessel model 10 through the insertion port 14.
  • water, physiological saline, an aqueous solution containing a surfactant, and the like flow into the blood vessel simulation unit 20 of the blood vessel model 10.
  • the air inside the blood vessel model 10 is discharged to the outside through an opening formed on the side end surface of the blood vessel simulating portion 20, an auxiliary passage 50, and the like.
  • the inside of the blood vessel simulation unit 20 of the blood vessel model 10 is filled with water, a physiological saline solution, an aqueous solution containing a surfactant, or the like.
  • a surfactant or a lubricating polymer may be applied in advance to the inner surface of the blood vessel simulating portion 20, or a hydrophilic lubricating polymer containing acrylamide or a hydrophobic lubricating polymer such as a fluororesin may be applied as the lubricating polymer. ..
  • the tester inserts a guiding catheter (not shown) from the insertion port 14 communicating with the connecting passage 21, reaches the tip of the proximal main passage 31, and inserts the microcatheter 100 inside the guiding catheter 100. It is made to reach the first main passage 32 from the connecting passage 21 through the base end main passage 31.
  • the tester selects the third branch passage 43 by the tip of the microcatheter 100 and attempts to push the microcatheter 100 into the third branch passage 43. Thereby, the tester can evaluate whether or not the microcatheter 100 could select the third branch passage 40 from the first main passage 32 by the blood vessel model 10. Since the inner diameter of the first main passage 32 is 8 mm and the inner diameter of the third branch passage 43 is 1 mm, the difference in inner diameter is large.
  • the microcatheter 100 may bend inside the first main passage 32 and deviate to the peripheral side (prolapse), and may escape from the third branch passage 43.
  • the tester can evaluate whether or not the microcatheter 100 has high support for sending the guide wire passing through the inside to the third branch passage 43 without prolapse.
  • the tester inserts the guide wire inserted into the microcatheter 100 into the third branch passage 43, and then causes the microcatheter 100 to follow the guide wire to peripherally attach the microcatheter 100. It is possible to evaluate whether or not it has bifurcation blood vessel selectivity for pushing it to the side.
  • the examiner inserts the microcatheter 100 from the insertion port 14 and communicates with the microcatheter 100 as shown in FIG. It is made to reach the second main passage 33 from the passage 21 through the base end main passage 31.
  • the tester selects the second bifurcation passage 42 by the tip of the microcatheter 100 and attempts to push the microcatheter 100 into the second bifurcation passage 42. Thereby, the tester can evaluate whether or not the second main passage 33 to the second branch passage 42 can be selected by the microcatheter 100 by the blood vessel model 10.
  • any branch passage 40 is selected from the above-mentioned first main passage 32 by the microcatheter 100. Compared with the case, it is easier to select the branch passage 40.
  • a peripheral branch passage 45 and a second peripheral branch passage are further branched on the peripheral side of the second branch passage 42 that branches from the second main passage 33. Therefore, can the examiner follow the guide wire to reach the peripheral bifurcation passage 45 and the second peripheral bifurcation passage (first bifurcation passage 41) by the blood vessel model 10 without prolapse? You can evaluate whether or not.
  • the first main passage 32 is branched from the base end main passage 31. Therefore, at the bifurcation of the proximal main passage 31 and the first main passage 32, can the microcatheter 100 follow the guide wire without dispersing the force for pushing the microcatheter 100 along the guide wire? You can evaluate whether or not.
  • the performance difference in the followability of the microcatheter 100 to the guide wire is the flexibility of the portion of the microcatheter 100 from the tip to the proximal end side of about 5 mm, the rigidity arrangement up to about 30 mm to the proximal end side, and more.
  • the tester decides to insert the microcatheter 100 from the third main passage 34 into any of the bifurcation passages 40, the tester can use this vessel model 10 to use any of the above-mentioned second main passages 33.
  • the same evaluation as when inserting into the branch passage 40 is possible.
  • the inner diameter of the third main passage 34 is 2 mm, which is smaller than the inner diameter of the second main passage 33, which is 5 mm. Therefore, since the range in which the microcatheter 100 and the guide wire can be bent is narrow (the range in which the pushing force escapes is small), the performance difference in the followability of the microcatheter 100 with respect to the guide wire is unlikely to occur. However, mainly when the difference in flexibility, rigid arrangement, outer diameter, etc. of the tip portion of the microcatheter 100 is relatively large, the performance difference of the microcatheter 100 is likely to appear, so the performance difference is evaluated by this blood vessel model 10. Is valid.
  • the tester decides to insert the microcatheter 100 from the fourth main passage 35 into any of the branch passages 40, the tester can use this vessel model 10 to use any of the above-mentioned second main passages 33.
  • the same evaluation as when inserting into the branch passage 40 is possible.
  • the inner diameter of the fourth main passage 35 is 1.2 mm, which is smaller than the inner diameter of the second main passage 33 of 5 mm and the inner diameter of the third main passage 34 of 2 mm. Therefore, since the range in which the microcatheter 100 and the guide wire can be bent is narrower (the range in which the pushing force escapes is small), the performance difference in the followability of the microcatheter 100 with respect to the guide wire is unlikely to occur.
  • the blood vessel model 10 has a blood vessel having a main passage 30 simulating a main blood vessel and a branch passage 40 thinner than the main passage 30 simulating a branch blood vessel branching from the main blood vessel.
  • the branch angles ⁇ 1 to ⁇ 4 of the branch passage 40 with respect to the main passage 30 exceed 0 degrees when the case where the branch passage 40 is folded back in the opposite direction to the main passage 30 is defined as 0 degrees. Is less than 90 degrees.
  • the blood vessel model 10 configured as described above can evaluate the selection performance of a medical long body for a bifurcated blood vessel that branches at an acute angle so as to be folded back from the main blood vessel.
  • the blood vessel model 10 has a plurality of branch passages 40 having different branch angles ⁇ 1 to ⁇ 4 with respect to the main passage 30. Thereby, one blood vessel model 10 can evaluate the selection performance of the medical long body in the branch passage 40 having various branch angles ⁇ 1 to ⁇ 4.
  • the blood vessel model 10 has a plurality of main passages 30 having different inner diameters, and a branch passage 40 branching from each main passage 30 is provided.
  • a branch passage 40 branching from each main passage 30 is provided.
  • the inner diameters of the plurality of main passages 30 having different inner diameters gradually decrease toward the peripheral side without branching from the main passage 30 or the proximal main passage 31.
  • the inner diameter of the second main passage 33 is 5 mm
  • the inner diameter of the third main passage 34 is 2 mm
  • the inner diameter of the fourth main passage 35 is 1.2 mm, which are gradually reduced.
  • the blood vessel model 10 has at least one peripheral branch passage 45 that branches on the peripheral side away from the main passage 30 of the branch passage 40. This makes it possible to evaluate the selection performance of a medical long body that continuously passes through a plurality of branches.
  • the blood vessel model 10 has a plurality of branch passages 40 having different branch angles with respect to the main passage 30, and at least one of the peripheral branch passages 45 provided on the periphery of the branch passage 40 is another branch passage 40. be.
  • the second peripheral branch passage provided in one periphery of the branch passage 40 can be reproduced by the other branch passage 40, so that the blood vessel model 10 can be realized compactly.
  • a plurality of main passages 30 are branched and provided.
  • the blood vessel model 10 having the plurality of main passages 30 can be compactly realized.
  • a plurality of branch passage groups 46 in which a plurality of branch passages 40 having different branch angles ⁇ 2 to ⁇ 4 with respect to the main passage 30 are arranged in the extending direction of the main passage 30 are provided at different positions in the circumferential direction of the main passage 30. .. Thereby, one blood vessel model 10 can evaluate the selection performance of the medical long body in various branch passages 40.
  • the evaluation method of the long medical body using the blood vessel model 10 according to the present embodiment is thinner than the main passage 30 simulating the main passage and the bifurcated blood vessel branching from the main blood vessel.
  • the branch passage 40 has a branch passage 40, and the branch angles ⁇ 1 to ⁇ 4 with respect to the main passage 30 of the branch passage 40 are 0 when the case where the branch passage 40 is folded back in the opposite direction to the main passage 30 is defined as 0 degrees.
  • a step of preparing a blood vessel model 10 which is more than 90 degrees and less than 90 degrees, a step of inserting a medical elongated body into the main passage 30 and trying to reach the branch passage 40 from the main passage 30, and a branch passage 40. It has a step of determining whether or not to reach.
  • the evaluation method configured as described above can easily evaluate the selection performance of a medical long body for a bifurcated blood vessel that branches at an acute angle so as to be folded back from the main blood vessel.
  • the blood vessel model 10 may be a jig.
  • the blood vessel model 10 may be connected to a sensor such as an autograph. Thereby, it is possible to detect the force acting on the blood vessel model 10 and the amount of movement of the blood vessel model 10 when the medical long body is inserted into the blood vessel model 10.
  • the blood vessel simulated by the blood vessel model 10 is not particularly limited, but is a prostate artery, a uterine artery, or a hepatic artery.
  • a branch passage having a branch angle of 90 degrees or more with respect to the main passage of the branch passage may be provided.
  • Vascular model 11 Divided simulated part 12 Holding plate 13 Connecting tool 14 Insertion port 15 Facing surface 20
  • Vascular simulated part 21 Connecting passage 30
  • Main passage 31 Base end main passage 32 1st main passage 33 2nd main passage 34 3rd main passage 35 4th main passage 40
  • Branch passage 41 1st branch passage 42 2nd branch passage 43 3rd branch passage 44 4th branch passage 45
  • Peripheral branch passage 46 Branch passage group 50 Auxiliary passage 100 Microcatheter (medical long body)

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Abstract

Le problème décrit par la présente invention est de pourvoir à : un modèle de vaisseau sanguin qui permette d'évaluer la performance de sélection d'un corps long médical pour un vaisseau sanguin de ramification résultant d'une ramification à un angle aigu de sorte qu'il est replié en arrière à partir d'un vaisseau sanguin principal ; et un procédé d'évaluation du corps long médical. La solution de la présente invention porte sur un modèle de vaisseau sanguin (10) comprenant : un passage principal (30) qui simule un vaisseau sanguin principal ; et des passages de ramification (40) qui simulent des vaisseaux sanguins de ramification résultant d'une ramification à partir du vaisseau sanguin principal et qui sont plus étroits que le passage principal (30). Dans le cas où on définit comme 0 degré un angle formé lorsqu'un passage de ramification (40) est replié dans une direction opposée à une direction du passage principal (30), les angles de ramification θ1 à θ4 des passages de ramification (40) par rapport au passage principal (30) sont tous supérieurs à 0 degré mais inférieurs à 90 degrés.
PCT/JP2021/024687 2020-07-01 2021-06-30 Modèle de vaisseau sanguin et procédé d'évaluation de corps long médical WO2022004770A1 (fr)

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JP2020114084 2020-07-01
JP2020-114084 2020-07-01

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Citations (4)

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US5112228A (en) * 1989-11-13 1992-05-12 Advanced Cardiovascular Systems, Inc. Vascular model
CN204130043U (zh) * 2014-09-03 2015-01-28 常州市第一人民医院 血管介入超选择性插管模拟训练装置
JP2017509924A (ja) * 2014-03-26 2017-04-06 アプライド メディカル リソーシーズ コーポレイション 模擬切開可能組織
JP2020091307A (ja) * 2018-12-03 2020-06-11 朝日インテック株式会社 血管モデル及び臓器シミュレータ

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112228A (en) * 1989-11-13 1992-05-12 Advanced Cardiovascular Systems, Inc. Vascular model
JP2017509924A (ja) * 2014-03-26 2017-04-06 アプライド メディカル リソーシーズ コーポレイション 模擬切開可能組織
CN204130043U (zh) * 2014-09-03 2015-01-28 常州市第一人民医院 血管介入超选择性插管模拟训练装置
JP2020091307A (ja) * 2018-12-03 2020-06-11 朝日インテック株式会社 血管モデル及び臓器シミュレータ

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