WO2021254514A1 - Biochemical test paper tube - Google Patents

Biochemical test paper tube Download PDF

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Publication number
WO2021254514A1
WO2021254514A1 PCT/CN2021/101113 CN2021101113W WO2021254514A1 WO 2021254514 A1 WO2021254514 A1 WO 2021254514A1 CN 2021101113 W CN2021101113 W CN 2021101113W WO 2021254514 A1 WO2021254514 A1 WO 2021254514A1
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WO
WIPO (PCT)
Prior art keywords
test paper
tube
biochemical test
cavity
cover
Prior art date
Application number
PCT/CN2021/101113
Other languages
French (fr)
Chinese (zh)
Inventor
喻晴
魏鹏海
周中人
Original Assignee
上海快灵生物科技有限公司
上海妙灵生物工程有限公司
上海金标生物科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 上海快灵生物科技有限公司, 上海妙灵生物工程有限公司, 上海金标生物科技有限公司 filed Critical 上海快灵生物科技有限公司
Publication of WO2021254514A1 publication Critical patent/WO2021254514A1/en

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082Test tubes per se
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082Test tubes per se
    • B01L3/50825Closing or opening means, corks, bungs

Definitions

  • the invention relates to the technical field of rapid detection devices, in particular to a biochemical test paper tube.
  • test tube When performing in vitro diagnosis or in vitro testing, in order to obtain qualitative results quickly, a combination of chromatography test paper and test tube is usually used as a rapid diagnostic tool or rapid detection tool. Generally speaking, the samples for diagnosis or testing usually have some dangers, such as certain toxicity and infectiousness. The used test tubes will be treated as medical waste.
  • test tube in the related art has some defects.
  • the tube part and cover part of some test tubes are of separate design, and the cover part is easy to fall off from the tube part, causing the substances and solutions in the tube part to flow outwards, polluting the environment and endangering the lives of workers.
  • the tube part and the cover part of some test tubes are designed as one-piece, but the sealing performance and connection firmness are not good. Under the action of external force, the cover part is easier to separate from the tube part, which will also cause the substance in the tube part, The solution flows outward.
  • the purpose of the present invention is to provide a biochemical test paper tube aiming at the deficiencies in the prior art.
  • the invention provides a biochemical test paper tube, comprising a tube part and a cover part, the tube part comprising:
  • a solution cavity a sealing platform is arranged on the top end surface of the solution cavity, the sealing platform is arranged all around the solution cavity, and the inner diameter of the nozzle is the maximum inner diameter of the pipe;
  • Test paper cavity used to hold biochemical test paper
  • the sealing platform and the top of the test paper cavity have a certain distance from the bottom of the cover part.
  • the top end surface of the test paper cavity is lower than the top end surface of the tube portion.
  • the cover part and the nozzle of the tube part are inserted into the fitting.
  • the horizontal distance between the sealing platform and the tube wall of the tube portion is at least 0.5 mm, and the vertical distance between the sealing platform and the tube wall is at least 0.5 mm.
  • the width of the sealing platform is at least 1 mm.
  • the distance between the sealing platform and the bottom of the cover part is at least 1 mm.
  • the tube part further includes:
  • the sealing film is connected with the sealing platform to seal the solution cavity.
  • the cover part of the biochemical test paper tube is connected to the tube part.
  • the biochemical test paper tube further includes a connecting part, and the tube part and the cover part are connected through the connecting part.
  • the cover includes:
  • a cavity is formed by the inner surface of the cover portion bulging outward.
  • the longitudinal section of the cavity is trapezoidal, circular arc or triangular.
  • the tube part further includes:
  • a counterbore unit the counterbore unit being arranged on the top of the nozzle of the pipe part;
  • the cover part when the cover part closes the tube part, the cover part cooperates with the counterbore unit.
  • the longitudinal section of the counterbore unit is stepped.
  • the counterbore unit includes:
  • a first counterbore the first counterbore being arranged at the top of the nozzle of the pipe part
  • a second counterbore the second counterbore being arranged on the lower side of the first counterbore
  • the width of the cross section of the first counterbore is greater than the width of the cross section of the second counterbore.
  • the tube part further includes:
  • the cover opening part is arranged in the first counterbore, the first end of the cover opening part is located at the inner wall of the first counterbore, and the second end of the cover opening part is located at the first counterbore.
  • the outer wall of a counterbore or is located between the outer wall of the first counterbore and the inner wall of the first counterbore.
  • the sealing film is arranged in the second counterbore and seals the solution cavity.
  • the cover further includes:
  • a chamfering part, the chamfering part is arranged on the outer wall of the cover;
  • the chamfering member is matched with the counterbore unit.
  • the tube part further includes:
  • a first fitting part the first fitting part being arranged on the inner wall of the upper part of the tube;
  • the cover part further includes:
  • a sealing member is arranged on the outer wall of the cover;
  • a second fitting part is arranged on the outer wall of the cover;
  • the second fitting member is located on the upper side of the sealing member, and the second fitting member is fitted and connected to the first fitting member .
  • the sealing member is an annular protrusion.
  • the first fitting part is an annular groove
  • the second fitting part is an annular protrusion
  • the width of the cross section of the second fitting member is smaller than the width of the cross section of the sealing member.
  • the plurality of the first fitting parts are arranged at intervals along the axial direction of the tube portion.
  • the cover further includes:
  • a bursting component is arranged inside the cover;
  • the bursting member destroys the sealing film.
  • the biochemical test paper tube further includes:
  • Biochemical test paper the biochemical test paper is arranged inside the test paper cavity
  • the sample solution receiving end of the biochemical test paper is close to the cover part.
  • the length of the biochemical test paper is greater than the height of the test paper cavity.
  • the difference between the length of the biochemical test paper and the height of the test paper cavity is 1 to 5 mm.
  • the biochemical test paper is an immunochromatography test paper
  • the immunochromatography test paper includes:
  • a chromatographic membrane is arranged on the upper surface of the substrate;
  • a water-absorbent pad, the water-absorbent pad is arranged on the lower surface of the substrate;
  • the chromatographic membrane and the water-absorbent pad are in contact with each other at the end of the substrate and transfer the solution.
  • the end of the chromatographic membrane exceeds the end of the substrate by a certain distance
  • the end of the absorbent pad exceeds the end of the substrate by a certain distance
  • the end of the chromatographic membrane is in contact with the end of the absorbent pad and transfers the solution.
  • the chromatographic membrane is also arranged on the lower surface of the substrate, and the end of the chromatographic membrane and the end of the absorbent pad are in contact with each other on the lower surface of the substrate to perform the solution. transfer.
  • the absorbent pad is also arranged on the upper surface of the substrate, and the end of the chromatographic membrane and the end of the absorbent pad are in contact on the upper surface of the substrate and transfer the solution. .
  • the immunochromatographic test paper further includes:
  • a bonding pad, the bonding pad is arranged on the substrate, the end of the bonding pad is in contact with the front end of the chromatography membrane and the solution is transferred to the chromatography membrane;
  • a guiding film the guiding film is arranged on the substrate, the end of the guiding film is in contact with the front end of the bonding pad and transferring the solution to the bonding pad;
  • the solution chromatography speed of the guiding membrane is lower than the solution chromatography speed of the binding pad.
  • the thickness of the guiding film is less than 0.15 mm.
  • the immunochromatographic test paper further includes:
  • the sample pad is arranged on the substrate, and the end of the sample pad is in contact with the front end of the guiding film and transfers the solution to the guiding film.
  • the immunochromatographic test paper further includes:
  • the sample pad is arranged on the substrate, and the end of the guiding film is in contact with the front end of the sample pad and transfers the solution to the sample pad.
  • the immunochromatographic test paper further includes:
  • a sample limiting film the sample limiting film is arranged on the substrate, the end of the sample limiting film is in contact with the front end of the guiding film, and the solution is transferred to the guiding film.
  • the absorption saturation volume of the sample limiting membrane is 2-20 ⁇ l.
  • the immunochromatographic test paper further includes:
  • the filter pad is arranged on the substrate, and the end of the guiding membrane is in contact with the front end of the filter pad and transfers the solution to the filter pad.
  • the immunochromatographic test paper further includes:
  • the water-retaining pad is arranged close to the front end of the guiding film.
  • the water-retaining pad of the immunochromatographic test paper fills the gap between the immunochromatographic test paper and the test paper fixing member.
  • the immunochromatographic test paper further includes:
  • a transparent protective film covering at least the chromatographic film and the bonding pad.
  • the chromatographic membrane includes a detection line and a quality control line arranged in sequence.
  • the lower surface of the end of the absorbent pad is in contact with the upper surface of the end of the chromatography membrane;
  • the upper surface of the end of the absorbent pad is in contact with the lower surface of the end of the chromatography membrane.
  • the lower surface of the end of the bonding pad is in contact with the upper surface of the front end of the chromatography membrane;
  • the upper surface of the end of the bonding pad is in contact with the lower surface of the front end of the chromatography membrane.
  • the lower surface of the end of the guiding film is in contact with the upper surface of the front end of the bonding pad;
  • the upper surface of the end of the guiding film is in contact with the lower surface of the front end of the bonding pad.
  • the lower surface of the end of the sample pad is in contact with the upper surface of the front end of the guiding film;
  • the upper surface of the end of the sample pad is in contact with the lower surface of the front end of the guiding film.
  • the lower surface of the end of the sample pad is in contact with the upper surface of the front end of the bonding pad
  • the upper surface of the end of the sample pad is in contact with the lower surface of the front end of the bonding pad.
  • the lower surface of the end of the guiding film is in contact with the upper surface of the front end of the sample pad;
  • the upper surface of the end of the guiding film is in contact with the lower surface of the front end of the sample pad.
  • the lower surface of the end of the guiding film is in contact with the upper surface of the front end of the filter pad;
  • the upper surface of the end of the guiding film is in contact with the lower surface of the front end of the filter pad.
  • the lower surface of the end of the filter pad is in contact with the concave surface of the front end of the bonding pad
  • the upper surface of the end of the filter pad is in contact with the lower surface of the front end of the bonding pad.
  • the lower surface of the end of the sample limiting film is in contact with the upper surface of the front end of the guiding film;
  • the upper surface of the end of the sample limiting film is in contact with the lower surface of the front end of the guiding film.
  • the length of the absorbent pad located on the upper surface of the substrate is greater than the length of the absorbent pad located on the lower surface of the substrate;
  • the length of the absorbent pad on the upper surface of the substrate is equal to the length of the absorbent pad on the lower surface of the substrate;
  • the length of the absorbent pad located on the upper surface of the substrate is less than the length of the absorbent pad located on the lower surface of the substrate.
  • the length of the chromatography membrane on the upper surface of the substrate is greater than the length of the chromatography membrane on the lower surface of the substrate;
  • the length of the chromatography membrane on the upper surface of the substrate is equal to the length of the chromatography membrane on the lower surface of the substrate;
  • the length of the chromatography membrane on the upper surface of the substrate is less than the length of the chromatography membrane on the lower surface of the substrate.
  • the detection line and the quality control line are located on the upper surface of the substrate.
  • the detection line is located on the upper surface of the substrate, and the quality control line is located on the lower surface of the substrate; or
  • the detection line and the quality control line are located on the lower surface of the substrate.
  • the biochemical test paper further includes:
  • a transparent hollow tube, the biochemical test paper is arranged inside the transparent hollow tube, and the transparent hollow tube is arranged inside the test paper cavity.
  • one end of the transparent hollow tube is a closed end.
  • the present invention adopts the above technical solutions and has the following technical effects:
  • a reaction solution is preset in the solution cavity, and a sealing film is used to seal the solution cavity.
  • a sealing film is used to seal the solution cavity.
  • Figure 1 is a cross-sectional view of an unclosed state of a biochemical test paper tube according to an embodiment of the present application (1);
  • Figure 2 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the present application (1);
  • Figure 3 is a cross-sectional view (2) of the biochemical test paper tube in an unclosed state according to an embodiment of the present application
  • FIG. 4 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the present application (2);
  • Fig. 5 is a schematic diagram (1) of the unclosed state of the biochemical test paper tube according to an embodiment of the present application
  • Figure 6 is a cross-sectional view of the biochemical test paper tube in an unclosed state according to an embodiment of the application (3);
  • Figure 7 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the application (3);
  • Figure 8 is a cross-sectional view of the biochemical test paper tube in an unclosed state according to an embodiment of the application (4);
  • Figure 9 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the present application (4);
  • FIG. 10 is a schematic diagram (2) of the unclosed state of the biochemical test paper tube according to an embodiment of the present application.
  • Figure 11 is a cross-sectional view (5) of the biochemical test paper tube in an unclosed state according to an embodiment of the present application
  • Figure 12 is a cross-sectional view of the biochemical test paper tube in an unclosed state according to an embodiment of the application (6);
  • Figure 13 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the present application (5);
  • Figure 14 is a cross-sectional view of the biochemical test paper tube in an unclosed state according to an embodiment of the present application (7);
  • Figure 16 is a schematic diagram (1) of an immunochromatographic test paper according to an embodiment of the present application.
  • Figure 17 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (1);
  • Fig. 18 is a cross-sectional view of a biochemical test paper tube according to an embodiment of the present application (with biochemical test paper);
  • Figure 19 is a schematic diagram of an immunochromatographic test paper according to an embodiment of the present application (2).
  • Figure 20 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (2);
  • Figure 21 is a schematic diagram of an immunochromatographic test paper according to an embodiment of the present application (3).
  • Figure 22 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (3);
  • Figure 23 is a schematic diagram of an immunochromatographic test paper according to an embodiment of the present application (4);
  • Figure 24 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the application (4);
  • Figure 25 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (5);
  • Figure 26 is a cross-sectional view of a transparent hollow tube according to an embodiment of the present application (1);
  • Figure 27 is a cross-sectional view of a transparent hollow tube according to an embodiment of the present application (2);
  • Fig. 28 is a cross-sectional view of a biochemical test paper tube (a biochemical test paper sheathed with a transparent hollow tube) according to an embodiment of the present application.
  • the reference signs are: 100, biochemical test paper tube; 110, tube part; 111, solution cavity; 112, test paper cavity; 113, sealing platform; 114, sealing film; 115, first counterbore; 116, second sink Hole; 117, cover opening part; 118, first fitting part; 120, cover part; 121, cavity; 122, limit part; 123, chamfering part; 124, bursting part; 125, sealing part; 126 , The second fitting part; 130, the connecting part;
  • biochemical test paper 210, substrate; 220, chromatographic membrane; 221, test line; 222, quality control line; 230, absorbent pad; 240, binding pad; 250, guiding membrane; 260, sample pad; 270, Sample limited film; 280, transparent protective film;
  • a biochemical test paper tube 100 includes a tube portion 110 and a cover portion 120, and the cover portion 120 is used to seal the tube portion 110.
  • the tube 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113 and a sealing film 114.
  • the axial direction of the solution chamber 111 is co-directed with the axial direction of the tube portion 110, and the solution chamber 111 is used for placing a solution, such as a reaction solution.
  • the axial direction of the test paper cavity 112 is parallel to the axial direction of the solution cavity 111, and the test paper cavity 112 is used for placing an immunochromatographic test paper.
  • the sealing platform 113 is arranged on the top end surface of the solution chamber 111 and is arranged all around the solution chamber 111.
  • the sealing film 114 is connected with the sealing platform 113 to seal the solution cavity 111 and prevent the solution in the solution cavity 111 from flowing out.
  • the solution cavity 111 is a regular-shaped cavity (such as a circular cavity, a rectangular cavity, and a trapezoidal cavity) or an irregular-shaped cavity.
  • the test paper cavity 112 is a regular-shaped cavity (such as a circular cavity, a rectangular cavity, and a trapezoidal cavity) or an irregular shape.
  • there may be several solution cavities 111 there may be several solution cavities 111, the axes of the several solution cavities 111 are parallel, at least one solution cavity 111 is used for placing biochemical reaction reagents or biochemical reaction solutions, and at least one solution cavity 111 is used for placing functions sexual reaction reagents.
  • functional reagents include, but are not limited to, degrading enzymes, lysis solutions, probes, buffers, diluents, etc., or reagents for subsequent reactions after the completion of the biochemical reaction.
  • test paper cavities 112 there may be several test paper cavities 112, the axes of the several test paper cavities 112 are parallel, and immunochromatographic test papers are placed in each test paper cavity 112, which can simultaneously detect different indicators of the same sample .
  • test paper cavities 112 are arranged around the axial direction of the tube 110 as a center.
  • sealing platform 113 There is a certain distance between the outer edge of the sealing platform 113 and the tube wall of the tube portion 110, and the sealing platform 113 is higher than the bottom surface of the tube wall and has a certain vertical distance.
  • the width of the sealing platform 113 is at least 1 mm; there is a certain horizontal distance between the outer wall of the sealing platform 113 and the inner wall of the pipe 110, and is at least 0.5 mm; the bottom wall of the sealing platform 113 and the inner wall of the pipe 110 are different There is a certain vertical distance between them, and at least 0.5mm.
  • the top of the sealing platform 113 does not contact the bottom of the pipe 110, that is, there is a certain vertical distance between the top of the sealing platform 113 and the bottom of the pipe 110, and is at least 1 mm .
  • top end surface of the sealing platform 113 and the top end surface of the pipe portion 110 may be located on the same horizontal plane; or, the top end surface of the sealing platform 113 is located below the top end surface of the pipe portion 110.
  • top end surface of the test paper cavity 112 is lower than the top end surface of the tube portion 110.
  • the reaction solution when leaving the factory, the reaction solution can be preset in the solution chamber 111, and then the solution chamber 111 can be sealed with the sealing film 114; or after leaving the factory, the inspector can prepare the reaction solution after getting the biochemical test paper tube 100 and The reaction solution is placed inside the solution cavity 111, and finally the solution cavity 111 is sealed with a sealing film 114, and the biochemical test paper tube 100 is stored for later use.
  • the sealing film 114 can also seal the test paper cavity 112.
  • the test paper cavity 112 can be sealed before the immunochromatography test paper is placed in the test paper cavity 112, that is, to prevent foreign matter from entering the test paper cavity 112; or the test paper cavity 112 can be sealed when the immunochromatography test paper is placed in the test paper cavity 112, that is, when the immunochromatography test paper is placed in the test paper cavity 112, Keep the immunochromatographic test paper free from external substances before use.
  • the sealing film 114 may be an aluminum foil film or a plastic film.
  • the sealing film 114 can be assembled with the biochemical test paper tube 100 during the production process, can also be assembled with the biochemical test paper tube 100 before the transportation process, or can be assembled with the biochemical test paper tube 100 before the storage process.
  • the shape of the sealing film 114 is substantially the same as the shape of the cavity at the top of the solution chamber 111, that is, the cross-sectional area of the sealing film 114 is slightly larger than the cross-sectional area of the cavity at the top of the solution cavity 111.
  • an auxiliary tool to break the sealing film 114 such as a tool with a sharp point, a blunt end, and a blade.
  • the shape of the sealing film 114 is different from the shape of the cavity opening at the top of the solution chamber 111, that is, the sealing film 114 includes a sealing part and an extension part.
  • the sealing part seals the solution chamber 111. Part of it is formed in one piece.
  • the shape of the sealing part is basically the same as the shape of the cavity opening at the top of the solution chamber 111.
  • the extension part is in a strip shape and is used to separate the sealing part from the solution chamber 111.
  • the cover 120 includes a cavity 121 formed by the inner surface of the cover 120 bulging outward, and is used to allow the solution in the solution cavity 111 to enter the cavity 121 when the biochemical test paper tube 100 is inclined. And contact with the immunochromatographic test paper in the test paper cavity 112.
  • the longitudinal section of the cavity 121 is trapezoidal, circular arc or triangular.
  • the cover 120 further includes a limiting member 122 which is provided on the outer wall of the cover 120 and is used to cooperate with the top of the tube 110 when the cover 120 closes the tube 110.
  • the limiting member 122 is an annular protrusion.
  • biochemical test paper tube 100 further includes a connecting part 130 which is connected to the tube part 110 and the cover part 120 respectively.
  • the tube portion 110, the cover portion 120, and the connecting portion 130 may be integrally connected, that is, the biochemical test paper tube 100 is a one-piece test tube.
  • the connection part 130 may be a connection bar.
  • the method of use in this embodiment is as follows: destroy or remove the sealing film 114, put the sample to be tested into the solution chamber 111, and mix the reaction solution in the solution chamber 111 with the sample to be tested to obtain a mixed solution; seal with the cover 120 Tube portion 110; After reacting for a certain period of time, tilt the tube portion 110 so that the sample solution receiving end of the immunochromatographic test paper arranged in the test paper cavity 112 contacts the mixed solution, and the mixed solution is chromatographed on the immunochromatographic test paper; The test result can be obtained by observing the immunochromatographic test paper; after observing the test result, the biochemical test paper tube 100 can be directly treated as medical waste without worrying about the leakage of the material in the biochemical test paper tube 100.
  • the biochemical test paper tube 100 includes a tube portion 110, a lid portion 120, and a connecting portion 130.
  • the tube portion 110 and the lid portion 120 are connected by the connecting portion 130. Closed.
  • the tube portion 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113, and a sealing film 114.
  • the connection relationship and structure of the solution cavity 111, the test paper cavity 112, and the sealing film 114 are basically the same as those in the first embodiment, and will not be repeated here. .
  • the cover 120 includes a cavity 121, wherein the connection relationship and structure of the cavity 121 are basically the same as those in the first embodiment, and will not be repeated here.
  • the cover 120 and the pipe 110 are externally fitted.
  • the maximum inner diameter of the cover 120 is the same as the outer diameter of the nozzle of the pipe 110, that is, the cover 120 is sleeved on the outside of the nozzle of the pipe 110.
  • a biochemical test paper tube 100 includes a tube portion 110, a cover portion 120, and a connecting portion 130.
  • the tube portion 110 and the cover portion 120 are connected by the connecting portion 130. Closed.
  • the tube portion 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113, a sealing film 114, and a counterbore unit.
  • the connection relationship and structure of the solution cavity 111, the test paper cavity 112, and the sealing film 114 are basically the same as those of the first embodiment. This will not be repeated here.
  • the counterbore unit is arranged on the top of the nozzle of the pipe 110 and is used to cooperate with the cover 120 when the cover 120 closes the pipe 110.
  • the shape of the outer wall of the cover 120 matches the shape of the inner wall of the counterbore unit. It is used to prevent the cover 120 from being removed from the counterbore unit without external force damage.
  • the longitudinal section of the counterbore unit is stepped.
  • the counterbore unit includes at least a first counterbore 115 and a second counterbore 116.
  • the first counterbore 115 is provided at the top of the nozzle of the pipe portion 110, and the second counterbore 116 is provided under the first counterbore 115. side.
  • the limiting member 122 of the lid 120 cooperates with the first counterbore 115 of the tube 110, so that the upper surface of the limiting member 122 and the upper surface of the first counterbore 115 Located on the same level.
  • Using this method of cooperation improves the anti-opening performance of the biochemical test paper tube 100. Without external force damage, it is difficult to separate the cover 120 from the tube 110 and prevent the test sample in the biochemical test paper tube 100 from leaking.
  • the width of the cross section of the first counterbore 115 is equal to the width of the cross section of the limiting member 122.
  • the inner diameter of the first counterbore 115 is equal to the outer diameter of the limiting member 122.
  • the width of the cross section of the first counterbore 115 is greater than the width of the cross section of the second counterbore 116.
  • the inner diameter of the first counterbore 115 is larger than the inner diameter of the second counterbore 116.
  • first counterbore 115 is also provided with a notch for accommodating the connecting portion 130.
  • the top of the solution cavity 111 ie, the mouth of the cavity
  • the top of the test paper cavity 112 ie, the mouth of the cavity
  • the sealing film 114 is disposed in the second counterbore 116 to seal at least the solution chamber 111.
  • the cover 120 further includes a chamfering member 123, which is arranged on the outer wall of the limiting member 122 and integrated with the limiting member 122 forming.
  • the width of the cross section of the upper end of the chamfering member 123 is smaller than the width of the cross section of the lower end of the chamfering member 123.
  • the limiting member 122 communicates with the chamfering member 123 and is provided in the first counterbore 115, that is, the upper surface of the limiting member 122, the upper surface of the chamfering member 123, and the first counterbore 115
  • the upper surface of 115 is on the same horizontal plane.
  • the tube 110 further includes an opening member 117, which is provided on the upper surface or inside of the first counterbore 115 for Under certain circumstances, the lid 120 is separated from the pipe 110 by the lid opening member 117.
  • the cover opening part 117 is provided through the first counterbore 115. Specifically, the first end of the lid opening member 117 is located on the inner wall of the first counterbore 115, and the second end of the lid opening member 117 is located on the outer wall of the first counterbore 115, and the lid opening member 117 is passed through with the aid of an auxiliary tool, such as a pry Use a rod to lift the lid 120 to separate the lid 120 from the tube 110.
  • an auxiliary tool such as a pry Use a rod to lift the lid 120 to separate the lid 120 from the tube 110.
  • the lid opening member 117 is provided on the upper surface of the first counterbore 115. Specifically, the first end of the opening member 117 is located on the inner wall of the first counterbore 115, and the second end of the opening member 117 is located between the inner wall and the outer wall of the first counterbore 115, passing through the opening member with the aid of an auxiliary tool. 117, such as an opening pick, tilts the cover 120 to separate the cover 120 from the tube 110.
  • the usage method of this embodiment is basically the same as that of Embodiment 1, and will not be repeated here.
  • the cover part when the cover part closes the pipe part, it is difficult to separate the cover part from the pipe part under the action of the counterbore unit; the effect of the chamfering part that is difficult to provide a force point, even if the external force is strong
  • the counterbore unit and the chamfering part cannot separate the cover and the tube; in some cases, the cover can be separated from the tube by the opening part to recover the solution or substance in the biochemical test paper tube.
  • a biochemical test paper tube 100 includes a tube portion 110, a lid portion 120, and a connecting portion 130.
  • the tube portion 110 and the lid portion 120 are connected by the connecting portion 130. Closed.
  • connection relationship and structure of the connecting portion 130 are basically the same as those of the first embodiment, and will not be repeated here.
  • the tube portion 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113, a sealing film 114, and a counterbore unit.
  • the connection relationship and structure of the solution cavity 111, the test paper cavity 112, the sealing film 114, and the counterbore unit are the same as those of the second embodiment. It's basically the same, so I won't repeat it here.
  • the cover 120 includes a cavity 121, a limiting member 122, and a bursting member 124.
  • the connection relationship and structure of the cavity 121 and the limiting member 122 are basically the same as those in the first embodiment, and will not be repeated here.
  • the bursting component 124 is disposed inside the cover 120, its first end is connected to the inner bottom surface of the cover 120, and its second end is located at the opening of the cover 120. In the case where the cover 120 does not completely close the pipe 110, the second end of the bursting member 124 contacts the sealing film 114 to break the sealing film 114.
  • the second end of the bursting component 124 may be a blunt end, a pointed end, or a blade part. It can break the sealing film 114 when it contacts the sealing film 114.
  • the bursting member 124 is a blade portion, there are at least two blade portions for cutting the sealing film 114.
  • the method of use in this embodiment is as follows: first move the cover 120 to the tube 110 so that the bursting part 124 contacts and breaks the sealing film 114 to expose the solution cavity 111; put the sample to be tested, such as a throat swab, into the solution cavity 111; the cap 120 is closed to the tube 110, and the limiting component 121 of the cap 120 is immersed in the first counterbore 115; after the reaction in the solution chamber 111 is complete, the biochemical test paper tube 100 is tilted to make the reaction solution contact The immunochromatographic test paper in the test paper cavity 112, the reaction solution is chromatographed on the immunochromatographic test paper, and the test result can be obtained by observing the immunochromatographic test paper; after the test result is observed, the biochemical test paper tube 100 can be directly used as There is no need to worry about the leakage of the material in the biochemical test paper tube 100 in the treatment of medical waste.
  • a bursting component is provided on the cover to destroy the sealing film, reducing the probability of pollution caused by artificially destroying the sealing film, and improving the accuracy of the detection result.
  • a biochemical test paper tube 100 includes a tube portion 110, a lid portion 120, and a connecting portion 130.
  • the tube portion 110 and the lid portion 120 are connected by the connecting portion 130. Closed.
  • connection relationship and structure of the connecting portion 130 are basically the same as those of the first embodiment, and will not be repeated here.
  • the tube portion 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113, a sealing film 114, a counterbore unit and a first fitting part 118, wherein the solution cavity 111, the test paper cavity 112, the sealing film 114, and the connection of the counterbore unit
  • the relationship and structure are basically the same as those in Embodiment 2, and will not be repeated here.
  • the first fitting members 118 are provided on the inner wall of the top of the pipe portion 110, and the first fitting members 118 are arranged at intervals along the axial direction of the pipe portion 110.
  • the first fitting part 118 is arranged on the inner wall of the second counterbore 116, and the first fitting part 118 is arranged at intervals along the axial direction of the second counterbore 116.
  • the cover 120 includes a cavity 121, a limiting component 122, a bursting component 124, a sealing component 125, and a second fitting component 126, wherein the connection relationship and structure of the cavity 121, the limiting component 122, and the bursting component 124 are the same Embodiment 3 is basically the same and will not be repeated here.
  • the sealing member 125 and the second fitting member 126 are spaced apart in the axial direction of the cover 120.
  • the sealing member 125 is located on the lower side of the lid 120
  • the second fitting member 126 is located on the upper side of the sealing member 125.
  • the sealing member 125 seals the tube 110, and the second fitting member 126 is fitted and connected to the first fitting member 118 so that the lid 120 and the tube 110 are tightly connected. connect.
  • the sealing member 125 is an annular protrusion whose outer diameter is equal to the inner diameter of the second counterbore 116 of the tube portion 110.
  • the tightness of the connection between the cover part and the pipe part is further improved, and the resistance to separate the cover part and the pipe part is greatly improved, which is effective Prevent leakage of the solution in the biochemical test paper tube, avoid polluting the environment, and prevent endangering life and health.
  • This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, a water-absorbing pad 230, a bonding pad 240, and a guiding membrane 250, wherein the guiding membrane 250, the binding pad 240, and the chromatographic membrane
  • the film 220 and the water absorbing pad 230 are sequentially arranged on the substrate 210.
  • the length of the biochemical test paper 200 is greater than the height of the test paper cavity 112.
  • the difference between the length of the biochemical test paper 200 and the height of the test paper cavity 112 is 1 mm to 5 mm, and the preferable difference is 2 mm and 3 mm.
  • the sample solution receiving end of the biochemical test paper 200 extends into the cavity 122 of the lid 120.
  • the substrate 210 is made of plastic, such as self-adhesive plastic.
  • the guiding film 250 is disposed on the upper surface of the substrate 210, that is, the lower surface of the guiding film 250 and the upper surface of the substrate 210 are connected, such as by bonding.
  • the end of the guiding film 250 is in contact with the front end of the bonding pad 240, and the guiding film 250 transfers the solution to the bonding pad 240.
  • the upper surface of the end of the guiding film 250 is in contact with the lower surface of the front end of the bonding pad 240, or the lower surface of the end of the guiding film 250 is in contact with the upper surface of the front end of the bonding pad 240.
  • the guiding film 250 is made of cellulose film.
  • the thickness of the guiding film 250 is less than 0.15 mm.
  • the bonding pad 240 is disposed on the upper surface of the substrate 210, that is, the lower surface of the bonding pad 240 and the upper surface of the substrate 210 are connected, such as by bonding.
  • the end of the bonding pad 240 is in contact with the front end of the chromatography membrane 220, and the bonding pad 240 transfers the solution to the chromatography membrane 220.
  • the upper surface of the end of the bonding pad 240 is in contact with the lower surface of the front end of the chromatography membrane 220, or the lower surface of the end of the bonding pad 240 is in contact with the upper surface of the front end of the chromatography membrane 220.
  • the bonding pad 240 is a colloidal gold pad.
  • the bonding pad 240 is made of glass fiber, polyester film, cellulose filter paper, non-woven fabric and other materials.
  • the solution chromatography speed of the guiding membrane 250 is lower than the solution chromatography speed of the bonding pad 240.
  • the chromatographic membrane 220 is disposed at least on the upper surface of the substrate 210, that is, the lower surface of the chromatographic membrane 220 and the upper surface of the substrate 210 are connected, such as by bonding.
  • the end of the chromatographic membrane 220 is in contact with the end of the absorbent pad 230, and the chromatographic membrane 220 transfers the solution to the absorbent pad 230.
  • the chromatographic membrane 220 is further provided with a detection line 221 and a quality control line 222, which are sequentially arranged along the front end to the end of the chromatographic membrane 220.
  • the chromatography membrane 220 is made of nitrocellulose membrane.
  • the absorbent pad 230 is disposed at least on the bottom surface of the substrate 210, that is, the top surface of the absorbent pad 230 and the bottom surface of the substrate 210 are connected, such as by bonding.
  • the end of the absorbent pad 230 is in contact with the end of the chromatography membrane 220.
  • the absorbent pad 230 is absorbent paper.
  • the end of the chromatographic membrane 220 and the end of the absorbent pad 230 are in contact with the end of the substrate 210 and the solution is transferred.
  • the end of the chromatography membrane 220 exceeds the end of the substrate 210 by a certain distance
  • the end of the absorbent pad 230 exceeds the end of the substrate 210 by a certain distance
  • the end of the chromatography membrane 220 and the absorbent pad The end of 230 contacts and performs solution transfer, that is, the lower surface of the end of the chromatography membrane 220 and the upper surface of the end of the absorbent pad 230 contact and transfer the solution.
  • the chromatography membrane 220, the substrate 210, and the absorbent pad 230 form a sandwich structure.
  • the chromatography membrane 220 is also disposed on the lower surface of the substrate 210, that is, the end of the chromatography membrane 220 is bent downward at the end of the substrate 210. Specifically, the upper surface of the end of the chromatography membrane 220 is in contact with the upper surface of the end of the absorbent pad 230 and the solution is transferred, or the lower surface of the end of the chromatography membrane 220 is in contact with the lower surface of the end of the absorbent pad 230 and the solution is transferred. transfer.
  • the length of the chromatography membrane 220 located on the upper surface of the substrate 210 is greater than the length of the chromatography membrane 220 located on the lower surface of the substrate 210; or, the chromatography membrane 220 located on the upper surface of the substrate 210 The length of is equal to the length of the chromatography membrane 220 on the lower surface of the substrate 210; or, the length of the chromatography membrane 220 on the upper surface of the substrate 210 is less than the length of the chromatography membrane 220 on the lower surface of the substrate 210.
  • the length of the chromatography membrane 220 located on the upper surface of the substrate 210 is greater than the length of the chromatography membrane 220 located on the lower surface of the substrate 210
  • the absorbent pad 230 is also disposed on the upper surface of the substrate 210, that is, the end of the absorbent pad 230 is bent upward at the end of the substrate 210. Specifically, the upper surface of the end of the absorbent pad 230 is in contact with the upper surface of the end of the chromatography membrane 220 and the solution is transferred, or the lower surface of the end of the absorbent pad 230 is in contact with the lower surface of the end of the chromatography membrane 220 and the solution is transferred. transfer.
  • the length of the absorbent pad 230 on the upper surface of the substrate 210 is greater than the length of the absorbent pad 230 on the lower surface of the substrate 210; or, the length of the absorbent pad 230 on the upper surface of the substrate 210 is equal to The length of the absorbent pad 230 on the bottom surface of the substrate 210; or, the length of the absorbent pad 230 on the top surface of the substrate 210 is less than the length of the absorbent pad 230 on the bottom surface of the substrate 210.
  • the length of the absorbent pad 230 on the upper surface of the substrate 210 is smaller than the length of the absorbent pad 230 on the lower surface of the substrate 210.
  • a thin film is also provided at the end of the chromatography membrane 220 and the end of the absorbent pad 230.
  • the thin film covers the chromatographic membrane 220 and the absorbent pad 230 to keep the chromatographic membrane 220 and the absorbent pad 230 in contact.
  • the length of the biochemical test paper 200 is 2 cm to 4 cm, preferably 2.8 cm, 3.0 cm, 3.2 cm, 3.5 cm.
  • This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, an absorbent pad 230, a bonding pad 240, a guiding film 250, and a sample pad 260, wherein the sample pad 260, the guiding film 250, the bonding pad 240, the chromatographic membrane 220 and the absorbent pad 230 are arranged on the substrate 210.
  • connection relationship, structure and composition of the substrate 210, the chromatographic membrane 220, the water-absorbing pad 230 and the bonding pad 240 are basically the same as those in Embodiment 1, and will not be repeated here.
  • the sample pad 260 is disposed on the upper surface of the substrate 210, that is, the lower surface of the sample pad 260 and the upper surface of the substrate 210 are connected, such as by bonding.
  • the sample pad 260 is made of glass fiber, polyester film, cellulose filter paper, non-woven fabric and other materials.
  • the end of the sample pad 260 is in contact with the front end of the guiding film 250, and the sample pad 260 transfers the solution to the guiding film 250.
  • the upper surface of the end of the sample pad 260 is in contact with the lower surface of the front end of the guide film 250, or the lower surface of the end of the sample pad 260 is in contact with the upper surface of the front end of the guide film 250.
  • the front end of the sample pad 260 is in contact with the end of the guiding film 250, and the guiding film 250 transfers the solution to the sample pad 260.
  • the upper surface of the end of the guiding film 250 is in contact with the lower surface of the front end of the sample pad 260, or the lower surface of the end of the guiding film 250 is in contact with the upper surface of the front end of the sample pad 260.
  • the end of the sample pad 260 is in contact with the front end of the bonding pad 240, and the sample pad 260 transfers the solution to the bonding pad 240.
  • the upper surface of the end of the sample pad 260 is in contact with the lower surface of the front end of the bonding pad 240, or the lower surface of the end of the sample pad 260 is in contact with the upper surface of the front end of the bonding pad 240.
  • the immunochromatographic test paper includes two guiding films 250 respectively arranged on the front and back sides of the sample pad 260, that is, the end of the first guiding film 250 and the sample pad 260
  • the first guiding film 250 transfers the solution to the sample pad 260.
  • the upper surface of the end of the first guiding film 250 is in contact with the lower surface of the front end of the sample pad 260, or the lower surface of the end of the first guiding film 250 is in contact with the upper surface of the front end of the sample pad 260 .
  • the end of the sample pad 260 is in contact with the second guiding film 250, and the sample pad 260 transfers the solution to the second guiding film 250.
  • the upper surface of the end of the sample pad 260 is in contact with the lower surface of the front end of the second guiding film 250, or the lower surface of the end of the sample pad 260 is in contact with the upper surface of the front end of the second guiding film 250.
  • the guiding membrane 250 may be the first guiding membrane; when there are two guiding membranes 250, the guiding membrane 250 close to the chromatographic membrane 220 may be The first guiding membrane, and the guiding membrane 250 away from the chromatographic membrane 220 may be the second guiding membrane.
  • the solution chromatography speed of the sample pad 260 is greater than the solution chromatography speed of the guiding membrane 250.
  • the length of the biochemical test paper 200 is 2 cm to 4 cm, preferably 3.2 cm, 3.5 cm.
  • This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, a water-absorbing pad 230, a bonding pad 240, a guiding film 250, and a sample limit film 270, wherein the sample limit film 270, the guide film
  • the guiding film 250, the bonding pad 240, the chromatographic film 220 and the water absorption pad 230 are sequentially arranged on the substrate 210.
  • connection relationship, structure and composition of the substrate 210, the chromatographic membrane 220, the water-absorbing pad 230, the bonding pad 240 and the guiding membrane 250 are basically the same as those of Embodiment 5, and will not be repeated here.
  • the sample limiting film 270 is disposed on the upper surface of the substrate 210, that is, the lower surface of the sample limiting film 270 is connected to the upper surface of the substrate 210, such as by bonding.
  • the end of the sample limiting film 270 is in contact with the front end of the guiding film 250, and the sample limiting film 270 transfers the solution to the guiding film 250.
  • the upper surface of the end of the sample limiting film 270 is in contact with the lower surface of the leading end of the guiding film 250, or the lower surface of the end of the sample limiting film 270 is in contact with the upper surface of the leading end of the guiding film 250.
  • the absorption saturation volume of the sample limiting membrane 270 is 2-20 ⁇ l, which can absorb a small amount of sample.
  • the sample limit film 270 is made of glass fiber, polyester film, cellulose filter paper and other materials.
  • the length of the biochemical test paper 200 is 2 cm to 4 cm, preferably 3.3 cm, 3.5 cm, 3.7 cm.
  • This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, an absorbent pad 230, a bonding pad 240, a guiding membrane 250, a sample pad 260, and a sample limit film 270.
  • the sample limit The membrane 270, the guiding membrane 250, the sample pad 260, the bonding pad 240, the chromatographic membrane 220 and the water absorption pad 230 are arranged on the substrate 210.
  • connection relationship, structure and composition of the substrate 210, the chromatographic membrane 220, the absorbent pad 230, the bonding pad 240, the guiding membrane 250 and the sample pad 260 are the same as those of the second embodiment and the third embodiment of Example 6. It's basically the same, so I won't repeat it here.
  • the sample limiting film 270 is disposed on the upper surface of the substrate 210, that is, the lower surface of the sample limiting film 270 is connected to the upper surface of the substrate 210, such as by bonding.
  • the end of the sample limiting film 270 is in contact with the front end of the guiding film 250, and the sample limiting film 270 transfers the solution to the guiding film 250.
  • the upper surface of the end of the sample limiting film 270 is in contact with the lower surface of the leading end of the guiding film 250, or the lower surface of the end of the sample limiting film 270 is in contact with the upper surface of the leading end of the guiding film 250.
  • the absorption saturation volume of the sample limiting membrane 270 is 2-20 ⁇ l, which can absorb a small amount of sample.
  • the sample limit film 270 is made of glass fiber, polyester film, cellulose filter paper and other materials.
  • the length of the biochemical test paper 200 is 2 cm to 4 cm, preferably 3.6 cm or 3.8 cm.
  • This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, a water-absorbing pad 230, a bonding pad 240, a guiding film 250, and a transparent protective film 280, wherein the guiding film 250 and the bonding pad 240 , The chromatographic membrane 220 and the absorbent pad 230 are sequentially arranged on the substrate 210.
  • connection relationship, structure and composition of the substrate 210, the chromatographic membrane 220, the water-absorbing pad 230, the bonding pad 240 and the guiding membrane 250 are basically the same as those of Embodiment 1, and will not be repeated here.
  • the lower surface of the transparent protective film 280 covers at least the bonding pad 240 and the chromatography film 220.
  • the use of the transparent protective film 280 can prevent the bonding pad 240 and the chromatography film 220 from contacting the exogenous aqueous mixture, and improve the accuracy of the detection result of the chromatography test paper.
  • the transparent protective film 280 can also be applied to the biochemical test papers of Examples 6-8.
  • the biochemical test paper 200 further includes a transparent hollow tube 300.
  • the transparent hollow tube 300 wraps the biochemical test paper 200 inside the transparent hollow tube 300, that is, the biochemical test paper 200 is disposed inside the transparent hollow tube 300.
  • the inner surface of the transparent hollow tube 300 is a hydrophobic surface.
  • the first end of the transparent hollow tube 300 is a closed end, and the second end is an open end.
  • the purpose of setting the open end is to facilitate the movement of the biochemical test paper 200 from the opening to the inside of the transparent hollow tube 300.
  • sample solution receiving end of the biochemical test paper 200 is located at the open end of the transparent hollow tube 300.
  • the transparent hollow tube 300 is made of a transparent material, such as plastic or thermoplastic resin, which is convenient for observing the detection or diagnosis result of the biochemical test paper 200.
  • the width of the cross section of the second end of the open end of the transparent hollow tube 300 is larger than the inner diameter of the cross section of the first end of the open end.
  • the width of the cross section of the open end of the transparent hollow tube 300 decreases from the second end of the open end to the first end of the open end.
  • putting the biochemical test paper 200 covered with a transparent hollow tube 300 into the test paper cavity 112 of the biochemical test paper tube 100 can prevent the biochemical test paper 200 from directly contacting the inner surface of the test paper cavity 112 and prevent the test paper cavity 112 from being damaged.
  • the surface tension of the inner surface affects the adsorption rate of the biochemical test paper 200.

Abstract

A biochemical test paper tube (100), comprising a tube portion (110) and a cover portion (120). The tube portion (110) comprises a solution chamber (111), wherein the top end face of the solution chamber (111) is provided with a sealing platform (113), the sealing platform (113) is entirely arranged around the solution chamber (111), and when the cover portion (120) closes the tube portion (110), the sealing platform (113) is a certain distance from the bottom of the cover portion (120); and a test paper chamber (112) for accommodating and placing biochemical test paper. The biochemical test paper tube has the advantages that a reaction solution is pre-placed in the solution chamber (111), and the solution chamber (111) is sealed by using a sealing film (114), and there is no need for detection personnel to prepare the solution and transfer the solution, thereby reducing the operation steps; and when in use, the sealing film (114) is destroyed, and a sample to be detected is placed in the solution chamber (111), so that rapid detection can be performed, thereby improving the detection efficiency.

Description

一种生化试纸管Biochemical test paper tube 技术领域Technical field
本发明涉及快速检测装置技术领域,尤其涉及一种生化试纸管。The invention relates to the technical field of rapid detection devices, in particular to a biochemical test paper tube.
背景技术Background technique
在进行体外诊断或体外检测时,为了能够快速地获得定性结果,通常会采用层析试纸与试管的组合作为快速诊断工具或快速检测工具。一般而言,进行诊断或检测的样品通常会具有一些危险性,如具有一定的毒性、传染性。使用完毕的试管会被当做医疗废弃物进行处理。When performing in vitro diagnosis or in vitro testing, in order to obtain qualitative results quickly, a combination of chromatography test paper and test tube is usually used as a rapid diagnostic tool or rapid detection tool. Generally speaking, the samples for diagnosis or testing usually have some dangers, such as certain toxicity and infectiousness. The used test tubes will be treated as medical waste.
然而,相关技术中的试管存在一些缺陷。例如,在检测时,需要进行反应溶液配制、取样等操作,耗时耗力。此外,部分试管的管部和盖部为分体式设计,盖部容易从管部脱落,使得管部内的物质、溶液向外流动,污染环境,危害工作人员的生命安全。此外,部分试管的管部和盖部为一体式设计,但是其密封性和连接牢固程度不佳,在施加外力的作用下,盖部较易从管部分离,同样会使管部内的物质、溶液向外流动。However, the test tube in the related art has some defects. For example, in the detection, the preparation of the reaction solution, sampling and other operations are required, which is time-consuming and labor-intensive. In addition, the tube part and cover part of some test tubes are of separate design, and the cover part is easy to fall off from the tube part, causing the substances and solutions in the tube part to flow outwards, polluting the environment and endangering the lives of workers. In addition, the tube part and the cover part of some test tubes are designed as one-piece, but the sealing performance and connection firmness are not good. Under the action of external force, the cover part is easier to separate from the tube part, which will also cause the substance in the tube part, The solution flows outward.
目前,针对相关技术中,存在反应溶液现配现用的情况,导致检测步骤多、检测效率低的问题,尚未提出有效的解决方案。At present, in the related technology, there is a situation that the reaction solution is prepared and used now, which leads to the problems of multiple detection steps and low detection efficiency, and no effective solution has been proposed.
发明内容Summary of the invention
本发明的目的是针对现有技术中的不足,提供一种生化试纸管。The purpose of the present invention is to provide a biochemical test paper tube aiming at the deficiencies in the prior art.
为实现上述目的,本发明采取的技术方案是:In order to achieve the above objectives, the technical solutions adopted by the present invention are:
本发明提供一种生化试纸管,包括管部和盖部,所述管部包括:The invention provides a biochemical test paper tube, comprising a tube part and a cover part, the tube part comprising:
溶液腔,所述溶液腔的顶部端面设置有密封平台,所述密封平台全部地环绕所述溶液腔设置,所述管口的内径为所述管部的最大内径;A solution cavity, a sealing platform is arranged on the top end surface of the solution cavity, the sealing platform is arranged all around the solution cavity, and the inner diameter of the nozzle is the maximum inner diameter of the pipe;
试纸腔,用于容纳放置生化试纸;Test paper cavity, used to hold biochemical test paper;
在所述盖部封闭所述管部的情况下,所述密封平台以及所述试纸腔的顶部与所述盖部的底部具有一定距离。When the cover part closes the tube part, the sealing platform and the top of the test paper cavity have a certain distance from the bottom of the cover part.
在其中的一个实施例中,所述试纸腔的顶部端面低于所述管部的顶部端面。In one of the embodiments, the top end surface of the test paper cavity is lower than the top end surface of the tube portion.
在其中的一个实施例中,所述盖部与所述管部的管口进行内插式配合。In one of the embodiments, the cover part and the nozzle of the tube part are inserted into the fitting.
在其中的一个实施例中,所述密封平台的外边缘与所述管部的管壁之间具有一定的间隔距离,所述密封平台高出所述管壁的底面且具有一定的垂直距离。In one of the embodiments, there is a certain separation distance between the outer edge of the sealing platform and the tube wall of the tube portion, and the sealing platform is higher than the bottom surface of the tube wall and has a certain vertical distance.
在其中的一个实施例中,所述密封平台与所述管部的管壁之间的水平距离至少为0.5mm,所述密封平台与所述管壁之间的垂直距离至少为0.5mm。In one of the embodiments, the horizontal distance between the sealing platform and the tube wall of the tube portion is at least 0.5 mm, and the vertical distance between the sealing platform and the tube wall is at least 0.5 mm.
在其中的一个实施例中,所述密封平台的宽度至少为1mm。In one of the embodiments, the width of the sealing platform is at least 1 mm.
在其中的一个实施例中,在所述盖部封闭所述管部的情况下,所述密封平台与所述盖部的底部之间的距离至少为1mm。In one of the embodiments, when the cover part closes the tube part, the distance between the sealing platform and the bottom of the cover part is at least 1 mm.
在其中的一个实施例中,所述管部还包括:In one of the embodiments, the tube part further includes:
密封膜,所述密封膜与所述密封平台连接以密封所述溶液腔。The sealing film is connected with the sealing platform to seal the solution cavity.
在其中的一个实施例中,生化试纸管所述盖部与所述管部相连。In one of the embodiments, the cover part of the biochemical test paper tube is connected to the tube part.
在其中的一个实施例中,所述生化试纸管还包括连接部,所述管部和所述盖部通过所述连接部连接。In one of the embodiments, the biochemical test paper tube further includes a connecting part, and the tube part and the cover part are connected through the connecting part.
在其中的一个实施例中,所述盖部包括:In one of the embodiments, the cover includes:
空腔,所述空腔由所述盖部的内表面向外凸起形成。A cavity is formed by the inner surface of the cover portion bulging outward.
在其中的一个实施例中,所述空腔的纵截面为梯形、圆弧形或三角形。In one of the embodiments, the longitudinal section of the cavity is trapezoidal, circular arc or triangular.
在其中的一个实施例中,所述管部还包括:In one of the embodiments, the tube part further includes:
沉孔单元,所述沉孔单元设置于所述管部的管口的顶部;A counterbore unit, the counterbore unit being arranged on the top of the nozzle of the pipe part;
其中,在所述盖部封闭所述管部的情况下,所述盖部与所述沉孔单元配合。Wherein, when the cover part closes the tube part, the cover part cooperates with the counterbore unit.
在其中的一个实施例中,所述沉孔单元的纵截面呈阶梯形。In one of the embodiments, the longitudinal section of the counterbore unit is stepped.
在其中的一个实施例中,所述沉孔单元包括:In one of the embodiments, the counterbore unit includes:
第一沉孔,所述第一沉孔设置于所述管部的管口的顶部;A first counterbore, the first counterbore being arranged at the top of the nozzle of the pipe part;
第二沉孔,所述第二沉孔设置于所述第一沉孔的下侧;A second counterbore, the second counterbore being arranged on the lower side of the first counterbore;
其中,所述第一沉孔的横截面的宽度大于所述第二沉孔的横截面的宽度。Wherein, the width of the cross section of the first counterbore is greater than the width of the cross section of the second counterbore.
在其中的一个实施例中,所述管部还包括:In one of the embodiments, the tube part further includes:
开盖部件,所述开盖部件设置于所述第一沉孔,所述开盖部件的第一端位于所述第一沉孔的内壁,所述开盖部件的第二端位于所述第一沉孔的外壁或位于所述第一沉孔的外壁与所述第一沉孔的内壁之间。The cover opening part is arranged in the first counterbore, the first end of the cover opening part is located at the inner wall of the first counterbore, and the second end of the cover opening part is located at the first counterbore. The outer wall of a counterbore or is located between the outer wall of the first counterbore and the inner wall of the first counterbore.
在其中的一个实施例中,所述密封膜设置于所述第二沉孔,并密封所述溶液腔。In one of the embodiments, the sealing film is arranged in the second counterbore and seals the solution cavity.
在其中的一个实施例中,所述盖部还包括:In one of the embodiments, the cover further includes:
倒角部件,所述倒角部件设置于所述盖部的外壁;A chamfering part, the chamfering part is arranged on the outer wall of the cover;
其中,在所述盖部封闭所述管部的情况下,所述倒角部件与所述沉孔单元配合。Wherein, when the cover part closes the tube part, the chamfering member is matched with the counterbore unit.
在其中的一个实施例中,所述管部还包括:In one of the embodiments, the tube part further includes:
第一嵌合部件,所述第一嵌合部件设置在所述管部的上部的内壁;A first fitting part, the first fitting part being arranged on the inner wall of the upper part of the tube;
所述盖部还包括:The cover part further includes:
密封部件,所述密封部件设置于所述盖部的外壁;A sealing member, the sealing member is arranged on the outer wall of the cover;
第二嵌合部件,所述第二嵌合部件设置于所述盖部的外壁;A second fitting part, the second fitting part being arranged on the outer wall of the cover;
其中,在所述盖部封闭所述管部的情况下,所述第二嵌合部件位于所述密封部件的上侧,所述第二嵌合部件与所述第一嵌合部件嵌合连接。Wherein, in the case where the cover portion closes the tube portion, the second fitting member is located on the upper side of the sealing member, and the second fitting member is fitted and connected to the first fitting member .
在其中的一个实施例中,所述密封部件为环形凸起。In one of the embodiments, the sealing member is an annular protrusion.
在其中的一个实施例中,所述第一嵌合部件为环形凹槽,所述第二嵌合部件为环形凸起。In one of the embodiments, the first fitting part is an annular groove, and the second fitting part is an annular protrusion.
在其中的一个实施例中,所述第二嵌合部件的横截面的宽度小于所述密封部件的横截面的宽度。In one of the embodiments, the width of the cross section of the second fitting member is smaller than the width of the cross section of the sealing member.
在其中的一个实施例中,所述第一嵌合部件为若干个,若干所述第一嵌合部件沿所述管部的轴向间隔设置。In one of the embodiments, there are a plurality of the first fitting parts, and the plurality of the first fitting parts are arranged at intervals along the axial direction of the tube portion.
在其中的一个实施例中,所述第二嵌合部件为若干个,若干所述第二嵌合部件沿所述盖部的轴向间隔设置。In one of the embodiments, there are several second fitting parts, and several second fitting parts are arranged at intervals along the axial direction of the cover.
在其中的一个实施例中,所述盖部还包括:In one of the embodiments, the cover further includes:
顶破部件,所述顶破部件设置与所述盖部的内部;A bursting component, the bursting component is arranged inside the cover;
其中,在所述盖部封闭所述管部的情况下,所述顶破部件破坏所述密封膜。Wherein, when the cover part closes the tube part, the bursting member destroys the sealing film.
在其中的一个实施例中,所述生化试纸管还包括:In one of the embodiments, the biochemical test paper tube further includes:
生化试纸,所述生化试纸设置于所述试纸腔的内部;Biochemical test paper, the biochemical test paper is arranged inside the test paper cavity;
其中,在所述盖部封闭所述管部的情况下,所述生化试纸的样品溶液接收端靠近所述盖部。Wherein, when the cover part closes the tube part, the sample solution receiving end of the biochemical test paper is close to the cover part.
在其中的一个实施例中,所述生化试纸的长度大于所述试纸腔的高度。In one of the embodiments, the length of the biochemical test paper is greater than the height of the test paper cavity.
在其中的一个实施例中,所述生化试纸的长度与所述试纸腔的高度的差值为1~5mm。In one of the embodiments, the difference between the length of the biochemical test paper and the height of the test paper cavity is 1 to 5 mm.
在其中的一个实施例中,所述生化试纸为免疫层析试纸,所述免疫层析试纸包括:In one of the embodiments, the biochemical test paper is an immunochromatography test paper, and the immunochromatography test paper includes:
基材;Substrate
层析膜,所述层析膜设置在所述基材的上表面;A chromatographic membrane, the chromatographic membrane is arranged on the upper surface of the substrate;
吸水垫,所述吸水垫设置在所述基材的下表面;A water-absorbent pad, the water-absorbent pad is arranged on the lower surface of the substrate;
其中,所述层析膜和所述吸水垫在所述基材的末端接触并进行溶液传递。Wherein, the chromatographic membrane and the water-absorbent pad are in contact with each other at the end of the substrate and transfer the solution.
在其中的一个实施例中,所述层析膜的末端超出所述基材的末端一定距离;In one of the embodiments, the end of the chromatographic membrane exceeds the end of the substrate by a certain distance;
所述吸水垫的末端超出所述基材的末端一定距离;The end of the absorbent pad exceeds the end of the substrate by a certain distance;
所述层析膜的末端和所述吸水垫的末端接触并进行溶液传递。The end of the chromatographic membrane is in contact with the end of the absorbent pad and transfers the solution.
在其中的一个实施例中,所述层析膜还设置在所述基材的下表面,所述层析膜的末端和所述吸水垫的末端在所述基材的下表面接触并进行溶液传递。In one of the embodiments, the chromatographic membrane is also arranged on the lower surface of the substrate, and the end of the chromatographic membrane and the end of the absorbent pad are in contact with each other on the lower surface of the substrate to perform the solution. transfer.
在其中的一个实施例中,所述吸水垫还设置在所述基材的上表面,所述层析膜的末端和所述吸水垫的末端在所述基材的上表面接触并进行溶液传递。In one of the embodiments, the absorbent pad is also arranged on the upper surface of the substrate, and the end of the chromatographic membrane and the end of the absorbent pad are in contact on the upper surface of the substrate and transfer the solution. .
在其中的一个实施例中,所述免疫层析试纸还包括:In one of the embodiments, the immunochromatographic test paper further includes:
结合垫,所述结合垫设置在所述基材,所述结合垫的末端和所述层析膜的前端接触并向所述层析膜传递溶液;A bonding pad, the bonding pad is arranged on the substrate, the end of the bonding pad is in contact with the front end of the chromatography membrane and the solution is transferred to the chromatography membrane;
导引膜,所述导引膜设置在所述基材,所述导引膜的末端和所述结合垫的前端接触并向所述结合垫传递溶液;A guiding film, the guiding film is arranged on the substrate, the end of the guiding film is in contact with the front end of the bonding pad and transferring the solution to the bonding pad;
其中,所述导引膜的溶液层析速度小于所述结合垫的溶液层析速度。Wherein, the solution chromatography speed of the guiding membrane is lower than the solution chromatography speed of the binding pad.
在其中的一个实施例中,所述导引膜的厚度小于0.15mm。In one of the embodiments, the thickness of the guiding film is less than 0.15 mm.
在其中的一个实施例中,所述免疫层析试纸还包括:In one of the embodiments, the immunochromatographic test paper further includes:
样品垫,所述样品垫设置在所述基材,所述样品垫的末端和所述导引膜的前端接触并向所述导引膜传递溶液。The sample pad is arranged on the substrate, and the end of the sample pad is in contact with the front end of the guiding film and transfers the solution to the guiding film.
在其中的一个实施例中,所述免疫层析试纸还包括:In one of the embodiments, the immunochromatographic test paper further includes:
样品垫,所述样品垫设置在所述基材,所述导引膜的末端和所述样品垫的前端接触并向所述样品垫传递溶液。The sample pad is arranged on the substrate, and the end of the guiding film is in contact with the front end of the sample pad and transfers the solution to the sample pad.
在其中的一个实施例中,所述免疫层析试纸还包括:In one of the embodiments, the immunochromatographic test paper further includes:
样品限量膜,所述样品限量膜设置在所述基材,所述样品限量膜的末端和所述导引膜的前端接触并向所述导引膜传递溶液。A sample limiting film, the sample limiting film is arranged on the substrate, the end of the sample limiting film is in contact with the front end of the guiding film, and the solution is transferred to the guiding film.
在其中的一个实施例中,所述样品限量膜的吸液饱和容积为2~20μl。In one of the embodiments, the absorption saturation volume of the sample limiting membrane is 2-20 μl.
在其中的一个实施例中,所述免疫层析试纸还包括:In one of the embodiments, the immunochromatographic test paper further includes:
过滤垫,所述过滤垫设置在所述基材,所述导引膜的末端和所述过滤垫的前端接触并向所述过滤垫传递溶液。The filter pad is arranged on the substrate, and the end of the guiding membrane is in contact with the front end of the filter pad and transfers the solution to the filter pad.
在其中的一个实施例中,所述免疫层析试纸还包括:In one of the embodiments, the immunochromatographic test paper further includes:
挡水垫,所述挡水垫靠近所述导引膜的前端设置。The water-retaining pad is arranged close to the front end of the guiding film.
在其中的一个实施例中,所述免疫层析试纸的的挡水垫填充所述免疫层析试纸与所述试纸固定部件的空隙。In one of the embodiments, the water-retaining pad of the immunochromatographic test paper fills the gap between the immunochromatographic test paper and the test paper fixing member.
在其中的一个实施例中,所述免疫层析试纸还包括:In one of the embodiments, the immunochromatographic test paper further includes:
透明保护膜,所述透明保护膜至少覆盖所述层析膜和所述结合垫。A transparent protective film covering at least the chromatographic film and the bonding pad.
在其中的一个实施例中,所述层析膜包括依次设置的检测线和质控线。In one of the embodiments, the chromatographic membrane includes a detection line and a quality control line arranged in sequence.
在其中的一个实施例中,所述吸水垫的末端的下表面和所述层析膜的末端的上表面接触;或In one of the embodiments, the lower surface of the end of the absorbent pad is in contact with the upper surface of the end of the chromatography membrane; or
所述吸水垫的末端的上表面和所述层析膜的末端的下表面接触。The upper surface of the end of the absorbent pad is in contact with the lower surface of the end of the chromatography membrane.
在其中的一个实施例中,所述结合垫的末端的下表面和所述层析膜的前端的上表面接触;或In one of the embodiments, the lower surface of the end of the bonding pad is in contact with the upper surface of the front end of the chromatography membrane; or
所述结合垫的末端的上表面和所述层析膜的前端的下表面接触。The upper surface of the end of the bonding pad is in contact with the lower surface of the front end of the chromatography membrane.
在其中的一个实施例中,所述导引膜的末端的下表面和所述结合垫的前端的上表面接触;或In one of the embodiments, the lower surface of the end of the guiding film is in contact with the upper surface of the front end of the bonding pad; or
所述导引膜的末端的上表面和所述结合垫的前端的下表面接触。The upper surface of the end of the guiding film is in contact with the lower surface of the front end of the bonding pad.
在其中的一个实施例中,所述样品垫的末端的下表面和所述导引膜的前端的上表面接触;或In one of the embodiments, the lower surface of the end of the sample pad is in contact with the upper surface of the front end of the guiding film; or
所述样品垫的末端的上表面和所述导引膜的前端的下表面接触。The upper surface of the end of the sample pad is in contact with the lower surface of the front end of the guiding film.
在其中的一个实施例中,所述样品垫的末端的下表面和所述结合垫的前端的上表面接触;或In one of the embodiments, the lower surface of the end of the sample pad is in contact with the upper surface of the front end of the bonding pad; or
所述样品垫的末端的上表面和所述结合垫的前端的下表面接触。The upper surface of the end of the sample pad is in contact with the lower surface of the front end of the bonding pad.
在其中的一个实施例中,所述导引膜的末端的下表面和所述样品垫的前端的上表面接触;或In one of the embodiments, the lower surface of the end of the guiding film is in contact with the upper surface of the front end of the sample pad; or
所述导引膜的末端的上表面和所述样品垫的前端的下表面接触。The upper surface of the end of the guiding film is in contact with the lower surface of the front end of the sample pad.
在其中的一个实施例中,所述导引膜的末端的下表面和所述过滤垫的前端的上表面接触;或In one of the embodiments, the lower surface of the end of the guiding film is in contact with the upper surface of the front end of the filter pad; or
所述导引膜的末端的上表面和所述过滤垫的前端的下表面接触。The upper surface of the end of the guiding film is in contact with the lower surface of the front end of the filter pad.
在其中的一个实施例中,所述过滤垫的末端的下表面和所述结合垫的前端的尚博凹面接触;或In one of the embodiments, the lower surface of the end of the filter pad is in contact with the concave surface of the front end of the bonding pad; or
所述过滤垫的末端的上表面和所述结合垫的前端的下表面接触。The upper surface of the end of the filter pad is in contact with the lower surface of the front end of the bonding pad.
在其中的一个实施例中,所述样品限量膜的末端的下表面和所述导引膜的前端的上表面接触;或In one of the embodiments, the lower surface of the end of the sample limiting film is in contact with the upper surface of the front end of the guiding film; or
所述样品限量膜的末端的上表面和所述导引膜的前端的下表面接触。The upper surface of the end of the sample limiting film is in contact with the lower surface of the front end of the guiding film.
在其中的一个实施例中,在所述吸水垫的末端位于所述基材的上表面,所述吸水垫的前端位于所述基材的下表面的情况下:In one of the embodiments, when the end of the absorbent pad is located on the upper surface of the substrate, and the front end of the absorbent pad is located on the lower surface of the substrate:
位于所述基材的上表面的所述吸水垫的长度大于位于所述基材的下表面的所述吸水垫的长 度;或The length of the absorbent pad located on the upper surface of the substrate is greater than the length of the absorbent pad located on the lower surface of the substrate; or
位于所述基材的上表面的所述吸水垫的长度等于位于所述基材的下表面的所述吸水垫的长度;或The length of the absorbent pad on the upper surface of the substrate is equal to the length of the absorbent pad on the lower surface of the substrate; or
位于所述基材的上表面的所述吸水垫的长度小于位于所述基材的下表面的所述吸水垫的长度。The length of the absorbent pad located on the upper surface of the substrate is less than the length of the absorbent pad located on the lower surface of the substrate.
在其中的一个实施例中,在所述层析膜的前端位于所述基材的上表面,所述层析膜的末端位于所述基材的下表面的情况下:In one of the embodiments, when the front end of the chromatography membrane is located on the upper surface of the substrate, and the end of the chromatography membrane is located on the lower surface of the substrate:
位于所述基材的上表面的所述层析膜的长度大于位于所述基材的下表面的所述层析膜的长度;或The length of the chromatography membrane on the upper surface of the substrate is greater than the length of the chromatography membrane on the lower surface of the substrate; or
位于所述基材的上表面的所述层析膜的长度等于位于所述基材的下表面的所述层析膜的长度;或The length of the chromatography membrane on the upper surface of the substrate is equal to the length of the chromatography membrane on the lower surface of the substrate; or
位于所述基材的上表面的所述层析膜的长度小于位于所述基材的下表面的所述层析膜的长度。The length of the chromatography membrane on the upper surface of the substrate is less than the length of the chromatography membrane on the lower surface of the substrate.
在其中的一个实施例中,所述检测线和所述质控线位于所述基材的上表面;或In one of the embodiments, the detection line and the quality control line are located on the upper surface of the substrate; or
所述检测线位于所述基材的上表面,所述质控线位于所述基材的下表面;或The detection line is located on the upper surface of the substrate, and the quality control line is located on the lower surface of the substrate; or
所述检测线和所述质控线位于所述基材的下表面。The detection line and the quality control line are located on the lower surface of the substrate.
在其中的一个实施例中,所述生化试纸还包括:In one of the embodiments, the biochemical test paper further includes:
透明中空管,所述生化试纸设置于所述透明中空管的内部,所述透明中空管设置于所述试纸腔的内部。A transparent hollow tube, the biochemical test paper is arranged inside the transparent hollow tube, and the transparent hollow tube is arranged inside the test paper cavity.
在其中的一个实施例中,所述透明中空管的一端为封闭端。In one of the embodiments, one end of the transparent hollow tube is a closed end.
本发明采用以上技术方案,与现有技术相比,具有如下技术效果:Compared with the prior art, the present invention adopts the above technical solutions and has the following technical effects:
本发明的一种生化试纸管,在溶液腔内预置反应溶液,并使用密封膜密封溶液腔,无须检测人员配置溶液、转移溶液,减少操作步骤;在使用时,破坏密封膜,将待检测样品放入溶液腔,即可进行快速检测,提高检测效率。In the biochemical test paper tube of the present invention, a reaction solution is preset in the solution cavity, and a sealing film is used to seal the solution cavity. There is no need for testing personnel to configure and transfer the solution, reducing operation steps; when in use, the sealing film is destroyed and the test The sample is put into the solution chamber, and rapid detection can be carried out, which improves the detection efficiency.
附图说明Description of the drawings
图1是根据本申请实施例的生化试纸管的未封闭状态的剖面图(一);Figure 1 is a cross-sectional view of an unclosed state of a biochemical test paper tube according to an embodiment of the present application (1);
图2是根据本申请实施例的生化试纸管的封闭状态的剖面图(一);Figure 2 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the present application (1);
图3是根据本申请实施例的生化试纸管的未封闭状态的剖面图(二);Figure 3 is a cross-sectional view (2) of the biochemical test paper tube in an unclosed state according to an embodiment of the present application;
图4是根据本申请实施例的生化试纸管的封闭状态的剖面图(二);4 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the present application (2);
图5是根据本申请实施例的生化试纸管的未封闭状态的示意图(一);Fig. 5 is a schematic diagram (1) of the unclosed state of the biochemical test paper tube according to an embodiment of the present application;
图6是根据本申请实施例的生化试纸管的未封闭状态的剖面图(三);Figure 6 is a cross-sectional view of the biochemical test paper tube in an unclosed state according to an embodiment of the application (3);
图7是根据本申请实施例的生化试纸管的封闭状态的剖面图(三);Figure 7 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the application (3);
图8是根据本申请实施例的生化试纸管的未封闭状态的剖面图(四);Figure 8 is a cross-sectional view of the biochemical test paper tube in an unclosed state according to an embodiment of the application (4);
图9是根据本申请实施例的生化试纸管的封闭状态的剖面图(四);Figure 9 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the present application (4);
图10是根据本申请实施例的生化试纸管的未封闭状态的示意图(二);FIG. 10 is a schematic diagram (2) of the unclosed state of the biochemical test paper tube according to an embodiment of the present application;
图11是根据本申请实施例的生化试纸管的未封闭状态的剖面图(五);Figure 11 is a cross-sectional view (5) of the biochemical test paper tube in an unclosed state according to an embodiment of the present application;
图12是根据本申请实施例的生化试纸管的未封闭状态的剖面图(六);Figure 12 is a cross-sectional view of the biochemical test paper tube in an unclosed state according to an embodiment of the application (6);
图13是根据本申请实施例的生化试纸管的封闭状态的剖面图(五);Figure 13 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the present application (5);
图14是根据本申请实施例的生化试纸管的未封闭状态的剖面图(七);Figure 14 is a cross-sectional view of the biochemical test paper tube in an unclosed state according to an embodiment of the present application (7);
图15是根据本申请实施例的生化试纸管的封闭状态的剖面图(六);15 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the application (6);
图16是根据本申请实施例的免疫层析试纸的示意图(一);Figure 16 is a schematic diagram (1) of an immunochromatographic test paper according to an embodiment of the present application;
图17是根据本申请实施例的免疫层析试纸的剖面图(一);Figure 17 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (1);
图18根据本申请实施例的生化试纸管的剖面图(设置有生化试纸);Fig. 18 is a cross-sectional view of a biochemical test paper tube according to an embodiment of the present application (with biochemical test paper);
图19是根据本申请实施例的免疫层析试纸的示意图(二);Figure 19 is a schematic diagram of an immunochromatographic test paper according to an embodiment of the present application (2);
图20是根据本申请实施例的免疫层析试纸的剖面图(二);Figure 20 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (2);
图21是根据本申请实施例的免疫层析试纸的示意图(三);Figure 21 is a schematic diagram of an immunochromatographic test paper according to an embodiment of the present application (3);
图22是根据本申请实施例的免疫层析试纸的剖面图(三);Figure 22 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (3);
图23是根据本申请实施例的免疫层析试纸的示意图(四);Figure 23 is a schematic diagram of an immunochromatographic test paper according to an embodiment of the present application (4);
图24是根据本申请实施例的免疫层析试纸的剖面图(四);Figure 24 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the application (4);
图25是根据本申请实施例的免疫层析试纸的剖面图(五);Figure 25 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (5);
图26是根据本申请实施例的透明中空管的剖面图(一);Figure 26 is a cross-sectional view of a transparent hollow tube according to an embodiment of the present application (1);
图27是根据本申请实施例的透明中空管的剖面图(二);Figure 27 is a cross-sectional view of a transparent hollow tube according to an embodiment of the present application (2);
图28是根据本申请实施例的生化试纸管的剖面图(设置有套设透明中空管的生化试纸)。Fig. 28 is a cross-sectional view of a biochemical test paper tube (a biochemical test paper sheathed with a transparent hollow tube) according to an embodiment of the present application.
其中的附图标记为:100、生化试纸管;110、管部;111、溶液腔;112、试纸腔;113、密封平台;114、密封膜;115、第一沉孔;116、第二沉孔;117、开盖部件;118、第一嵌合部件;120、盖部;121、空腔;122、限位部件;123、倒角部件;124、顶破部件;125、密封部件;126、第二嵌合部件;130、连接部;The reference signs are: 100, biochemical test paper tube; 110, tube part; 111, solution cavity; 112, test paper cavity; 113, sealing platform; 114, sealing film; 115, first counterbore; 116, second sink Hole; 117, cover opening part; 118, first fitting part; 120, cover part; 121, cavity; 122, limit part; 123, chamfering part; 124, bursting part; 125, sealing part; 126 , The second fitting part; 130, the connecting part;
200、生化试纸;210、基材;220、层析膜;221、检测线;222、质控线;230、吸水垫;240、结合垫;250、导引膜;260、样品垫;270、样品限量膜;280、透明保护膜;200, biochemical test paper; 210, substrate; 220, chromatographic membrane; 221, test line; 222, quality control line; 230, absorbent pad; 240, binding pad; 250, guiding membrane; 260, sample pad; 270, Sample limited film; 280, transparent protective film;
300、透明中空管。300. Transparent hollow tube.
具体实施方式detailed description
下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动的前提下所获得的所有其他实施例,都属于本发明保护的范围。The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.
需要说明的是,在不冲突的情况下,本发明中的实施例及实施例中的特征可以相互组合。It should be noted that the embodiments of the present invention and the features in the embodiments can be combined with each other if there is no conflict.
下面结合附图和具体实施例对本发明作进一步说明,但不作为本发明的限定。The present invention will be further described below in conjunction with the drawings and specific embodiments, but it is not a limitation of the present invention.
实施例1Example 1
如图1~2所示,一种生化试纸管100,包括管部110和盖部120,盖部120用于对管部110进行封闭。As shown in FIGS. 1 to 2, a biochemical test paper tube 100 includes a tube portion 110 and a cover portion 120, and the cover portion 120 is used to seal the tube portion 110.
管部110包括溶液腔111、试纸腔112、密封平台113和密封膜114。溶液腔111的轴向与管部110的轴向共向,溶液腔111用于放置溶液,如反应溶液。试纸腔112的轴向与溶液腔111的轴向平行,试纸腔112用于放置免疫层析试纸。密封平台113设置在溶液腔111的顶部端面,且全部地环绕溶液腔111设置。密封膜114与密封平台113连接以密封溶液腔111,防止溶液腔111内的溶液流出。The tube 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113 and a sealing film 114. The axial direction of the solution chamber 111 is co-directed with the axial direction of the tube portion 110, and the solution chamber 111 is used for placing a solution, such as a reaction solution. The axial direction of the test paper cavity 112 is parallel to the axial direction of the solution cavity 111, and the test paper cavity 112 is used for placing an immunochromatographic test paper. The sealing platform 113 is arranged on the top end surface of the solution chamber 111 and is arranged all around the solution chamber 111. The sealing film 114 is connected with the sealing platform 113 to seal the solution cavity 111 and prevent the solution in the solution cavity 111 from flowing out.
在盖部120封闭管部110的情况下,溶液腔111的顶部和试纸腔112的顶部连通。When the lid 120 closes the tube 110, the top of the solution chamber 111 and the top of the test paper chamber 112 communicate.
其中,溶液腔111为规则形状腔室(如圆形腔室、矩形腔室、梯形腔室)或不规则形状腔室。试纸腔112为规则形状腔室(如圆形腔室、矩形腔室、梯形腔室)或不规则形状。Wherein, the solution cavity 111 is a regular-shaped cavity (such as a circular cavity, a rectangular cavity, and a trapezoidal cavity) or an irregular-shaped cavity. The test paper cavity 112 is a regular-shaped cavity (such as a circular cavity, a rectangular cavity, and a trapezoidal cavity) or an irregular shape.
在其中的一个实施方式中,溶液腔111可以是若干个,若干个溶液腔111的轴线平行,至少一个溶液腔111用于放置生化反应试剂或生化反应溶液,至少一个溶液腔111用于放置功能性反应试剂。其中,功能性试剂包括但不限于降解酶、裂解液、探针、缓冲液、稀释液等,或者是生化反应完成后进行后续反应的试剂。In one of the embodiments, there may be several solution cavities 111, the axes of the several solution cavities 111 are parallel, at least one solution cavity 111 is used for placing biochemical reaction reagents or biochemical reaction solutions, and at least one solution cavity 111 is used for placing functions Sexual reaction reagents. Among them, functional reagents include, but are not limited to, degrading enzymes, lysis solutions, probes, buffers, diluents, etc., or reagents for subsequent reactions after the completion of the biochemical reaction.
在其中的一个实施方式中,试纸腔112可以是若干个,若干个试纸腔112的轴线平行,每个试纸腔112内均放置有免疫层析试纸,可以同时对同一个样品的不同指标进行检测。In one of the embodiments, there may be several test paper cavities 112, the axes of the several test paper cavities 112 are parallel, and immunochromatographic test papers are placed in each test paper cavity 112, which can simultaneously detect different indicators of the same sample .
其中,若干试纸腔112以管部110的轴向为中心环绕设置。Wherein, a plurality of test paper cavities 112 are arranged around the axial direction of the tube 110 as a center.
密封平台113的外边缘与管部110的管壁之间具有一定的间隔距离,密封平台113高出管壁的底面且具有一定的垂直距离。There is a certain distance between the outer edge of the sealing platform 113 and the tube wall of the tube portion 110, and the sealing platform 113 is higher than the bottom surface of the tube wall and has a certain vertical distance.
具体地,密封平台113的宽度至少为1mm;密封平台113的外壁与管部110的内壁之间具有一定的水平距离,且至少为0.5mm;密封平台113的底壁与管部110的内壁之间具有一定的垂直距离,且至少为0.5mm。Specifically, the width of the sealing platform 113 is at least 1 mm; there is a certain horizontal distance between the outer wall of the sealing platform 113 and the inner wall of the pipe 110, and is at least 0.5 mm; the bottom wall of the sealing platform 113 and the inner wall of the pipe 110 are different There is a certain vertical distance between them, and at least 0.5mm.
在盖部120封闭管部110的情况下,密封平台113的顶部与管部110的底部不接触,即密封平台113的顶部与管部110的底部之间具有一定的垂直距离,且至少为1mm。When the cover 120 closes the pipe 110, the top of the sealing platform 113 does not contact the bottom of the pipe 110, that is, there is a certain vertical distance between the top of the sealing platform 113 and the bottom of the pipe 110, and is at least 1 mm .
此外,密封平台113的顶部端面可以与管部110的顶部端面位于同一水平面;或者,密封平台113的顶部端面位于管部110的顶部端面的下方。In addition, the top end surface of the sealing platform 113 and the top end surface of the pipe portion 110 may be located on the same horizontal plane; or, the top end surface of the sealing platform 113 is located below the top end surface of the pipe portion 110.
此外,试纸腔112的顶部端面低于管部110的顶部端面。In addition, the top end surface of the test paper cavity 112 is lower than the top end surface of the tube portion 110.
其中,在出厂的时候,可以在溶液腔111内预置反应溶液,然后使用密封膜114对溶液腔111进行密封;或者,出厂后,检测人员拿到生化试纸管100后,配置反应溶液,并将反应溶液放置到溶液腔111的内部,最后使用密封膜114密封溶液腔111,将生化试纸管100储存后备用。Among them, when leaving the factory, the reaction solution can be preset in the solution chamber 111, and then the solution chamber 111 can be sealed with the sealing film 114; or after leaving the factory, the inspector can prepare the reaction solution after getting the biochemical test paper tube 100 and The reaction solution is placed inside the solution cavity 111, and finally the solution cavity 111 is sealed with a sealing film 114, and the biochemical test paper tube 100 is stored for later use.
此外,密封膜114还可以密封试纸腔112。具体地,可以在免疫层析试纸放置在试纸腔112之前对试纸腔112密封,即避免异物进入试纸腔112;也可以在免疫层析试纸放置在试纸腔112时候对试纸腔112密封,即在未使用前保持免疫层析试纸不受外界物质影响。In addition, the sealing film 114 can also seal the test paper cavity 112. Specifically, the test paper cavity 112 can be sealed before the immunochromatography test paper is placed in the test paper cavity 112, that is, to prevent foreign matter from entering the test paper cavity 112; or the test paper cavity 112 can be sealed when the immunochromatography test paper is placed in the test paper cavity 112, that is, when the immunochromatography test paper is placed in the test paper cavity 112, Keep the immunochromatographic test paper free from external substances before use.
其中,密封膜114可以是铝箔膜,可以是塑封膜。密封膜114可以在生产过程中与生化试纸管100进行装配,也可以在运输过程前与生化试纸管100进行装配,也可以在储存过程前与生化试纸管100进行装配。Wherein, the sealing film 114 may be an aluminum foil film or a plastic film. The sealing film 114 can be assembled with the biochemical test paper tube 100 during the production process, can also be assembled with the biochemical test paper tube 100 before the transportation process, or can be assembled with the biochemical test paper tube 100 before the storage process.
此外,密封膜114的形状与溶液腔111的顶部的腔口的形状基本相同,即密封膜114的横截面的面积略大于溶液腔111的顶部的腔口的横截面的面积。在这种情况下,需要借助辅助工具破坏密封膜114,如具有尖端、钝端、刃部的工具。In addition, the shape of the sealing film 114 is substantially the same as the shape of the cavity at the top of the solution chamber 111, that is, the cross-sectional area of the sealing film 114 is slightly larger than the cross-sectional area of the cavity at the top of the solution cavity 111. In this case, it is necessary to use an auxiliary tool to break the sealing film 114, such as a tool with a sharp point, a blunt end, and a blade.
此外,密封膜114的形状与溶液腔111的顶部的腔口的形状不同,即密封膜114包括密封部分和延伸部分,密封部分密封溶液腔111,延伸部分设置在密封部分的侧部并与密封部分一体成型。其中,密封部分的形状与溶液腔111的顶部的腔口的形状基本相同。延伸部分呈条状,用于使密封部分与溶液腔111分离。In addition, the shape of the sealing film 114 is different from the shape of the cavity opening at the top of the solution chamber 111, that is, the sealing film 114 includes a sealing part and an extension part. The sealing part seals the solution chamber 111. Part of it is formed in one piece. The shape of the sealing part is basically the same as the shape of the cavity opening at the top of the solution chamber 111. The extension part is in a strip shape and is used to separate the sealing part from the solution chamber 111.
盖部120包括空腔121,空腔121由盖部120的内表面向外凸起形成,用于在生化试纸管100倾斜的情况下,使溶液腔111内的溶液进入到空腔121内,并与试纸腔112内的免疫层析试纸接触。The cover 120 includes a cavity 121 formed by the inner surface of the cover 120 bulging outward, and is used to allow the solution in the solution cavity 111 to enter the cavity 121 when the biochemical test paper tube 100 is inclined. And contact with the immunochromatographic test paper in the test paper cavity 112.
其中,空腔121的纵截面为梯形、圆弧形或三角形。Wherein, the longitudinal section of the cavity 121 is trapezoidal, circular arc or triangular.
此外,盖部120还包括限位部件122,限位部件122设置在盖部120的外壁,用于在盖部120封闭管部110的情况下,与管部110的顶部配合。In addition, the cover 120 further includes a limiting member 122 which is provided on the outer wall of the cover 120 and is used to cooperate with the top of the tube 110 when the cover 120 closes the tube 110.
其中,限位部件122为环形凸起。Wherein, the limiting member 122 is an annular protrusion.
此外,生化试纸管100还包括连接部130,连接部130分别与管部110、盖部120连接。In addition, the biochemical test paper tube 100 further includes a connecting part 130 which is connected to the tube part 110 and the cover part 120 respectively.
其中,管部110、盖部120和连接部130可以是一体式连接,即生化试纸管100为连体式试管。在这种情况下,连接部130可以是连接条。Wherein, the tube portion 110, the cover portion 120, and the connecting portion 130 may be integrally connected, that is, the biochemical test paper tube 100 is a one-piece test tube. In this case, the connection part 130 may be a connection bar.
本实施例的使用方法如下:破坏或移除密封膜114,将待检测样品置入溶液腔111的内部,溶液腔111内的反应溶液与待检测样品混合,得到混合液;用盖部120封闭管部110;待反应一定时间后,倾斜管部110,使设置于试纸腔112内的免疫层析试纸的样品溶液接收端接触混合液,混合液在免疫层析试纸上进行层析作用;通过观察免疫层析试纸即可获知检测结果;在观察到检测结果之后,可以直接将生化试纸管100当做医疗废弃物处理,无须担忧生化试纸管100内的物质泄漏。The method of use in this embodiment is as follows: destroy or remove the sealing film 114, put the sample to be tested into the solution chamber 111, and mix the reaction solution in the solution chamber 111 with the sample to be tested to obtain a mixed solution; seal with the cover 120 Tube portion 110; After reacting for a certain period of time, tilt the tube portion 110 so that the sample solution receiving end of the immunochromatographic test paper arranged in the test paper cavity 112 contacts the mixed solution, and the mixed solution is chromatographed on the immunochromatographic test paper; The test result can be obtained by observing the immunochromatographic test paper; after observing the test result, the biochemical test paper tube 100 can be directly treated as medical waste without worrying about the leakage of the material in the biochemical test paper tube 100.
实施例2Example 2
如图3~4所示,种生化试纸管100,包括管部110、盖部120和连接部130,管部110和盖部120通过连接部130连接,盖部120用于对管部110进行封闭。As shown in Figures 3 to 4, the biochemical test paper tube 100 includes a tube portion 110, a lid portion 120, and a connecting portion 130. The tube portion 110 and the lid portion 120 are connected by the connecting portion 130. Closed.
管部110包括溶液腔111、试纸腔112、密封平台113和密封膜114,其中,溶液腔111、试纸腔112、密封膜114的连接关系和结构同实施例1基本相同,在此不再赘述。The tube portion 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113, and a sealing film 114. The connection relationship and structure of the solution cavity 111, the test paper cavity 112, and the sealing film 114 are basically the same as those in the first embodiment, and will not be repeated here. .
盖部120包括空腔121,其中,空腔121的连接关系和结构同实施例1基本相同,在此不再赘述。The cover 120 includes a cavity 121, wherein the connection relationship and structure of the cavity 121 are basically the same as those in the first embodiment, and will not be repeated here.
在本实施例中,盖部120与管部110进行外插式配合。具体地,盖部120的最大内径与管部110的管口的外径相同,即盖部120套设于管部110的管口的外部。In this embodiment, the cover 120 and the pipe 110 are externally fitted. Specifically, the maximum inner diameter of the cover 120 is the same as the outer diameter of the nozzle of the pipe 110, that is, the cover 120 is sleeved on the outside of the nozzle of the pipe 110.
实施例3Example 3
如图5~7所示,一种生化试纸管100,包括管部110、盖部120和连接部130,管部110和盖部120通过连接部130连接,盖部120用于对管部110进行封闭。As shown in Figures 5-7, a biochemical test paper tube 100 includes a tube portion 110, a cover portion 120, and a connecting portion 130. The tube portion 110 and the cover portion 120 are connected by the connecting portion 130. Closed.
管部110包括溶液腔111、试纸腔112、密封平台113、密封膜114和沉孔单元,其中,溶液腔111、试纸腔112、密封膜114的连接关系和结构同实施例1基本相同,在此不再赘述。The tube portion 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113, a sealing film 114, and a counterbore unit. The connection relationship and structure of the solution cavity 111, the test paper cavity 112, and the sealing film 114 are basically the same as those of the first embodiment. This will not be repeated here.
沉孔单元设置于管部110的管口的顶部,用于在盖部120封闭管部110的情况下与盖部120配合。盖部120的外壁的形状与沉孔单元的内壁的形状相配合。用于在无外力破坏作用下,盖部 120无法从沉孔单元移除。The counterbore unit is arranged on the top of the nozzle of the pipe 110 and is used to cooperate with the cover 120 when the cover 120 closes the pipe 110. The shape of the outer wall of the cover 120 matches the shape of the inner wall of the counterbore unit. It is used to prevent the cover 120 from being removed from the counterbore unit without external force damage.
沉孔单元的纵截面呈阶梯形。具体地,沉孔单元至少包括第一沉孔115和第二沉孔116,第一沉孔115设置于管部110的管口的顶部,第二沉孔116设置于第一沉孔115的下侧。The longitudinal section of the counterbore unit is stepped. Specifically, the counterbore unit includes at least a first counterbore 115 and a second counterbore 116. The first counterbore 115 is provided at the top of the nozzle of the pipe portion 110, and the second counterbore 116 is provided under the first counterbore 115. side.
在盖部120封闭管部110的情况下,盖部120的限位部件122与管部110的第一沉孔115相配合,使得限位部件122的上表面与第一沉孔115的上表面位于同一水平面。利用这种配合方式,提高生化试纸管100的防开启性能,在无外力破坏作用下,难以将盖部120与管部110分离,防止生化试纸管100内的检测样品泄漏。When the lid 120 closes the tube 110, the limiting member 122 of the lid 120 cooperates with the first counterbore 115 of the tube 110, so that the upper surface of the limiting member 122 and the upper surface of the first counterbore 115 Located on the same level. Using this method of cooperation improves the anti-opening performance of the biochemical test paper tube 100. Without external force damage, it is difficult to separate the cover 120 from the tube 110 and prevent the test sample in the biochemical test paper tube 100 from leaking.
此外,第一沉孔115的横截面的宽度与限位部件122的横截面的宽度相等。具体地,第一沉孔115的内径与限位部件122的外径相等。In addition, the width of the cross section of the first counterbore 115 is equal to the width of the cross section of the limiting member 122. Specifically, the inner diameter of the first counterbore 115 is equal to the outer diameter of the limiting member 122.
其中,第一沉孔115的横截面的宽度大于第二沉孔116的横截面的宽度。具体地,第一沉孔115的内径大于第二沉孔116的内径。Wherein, the width of the cross section of the first counterbore 115 is greater than the width of the cross section of the second counterbore 116. Specifically, the inner diameter of the first counterbore 115 is larger than the inner diameter of the second counterbore 116.
此外,第一沉孔115还设置有用于容纳连接部130的缺口。In addition, the first counterbore 115 is also provided with a notch for accommodating the connecting portion 130.
此外,溶液腔111的顶部(即腔口)和试纸腔112的顶部(即腔口)位于第二沉孔116。因此,密封膜114设置于第二沉孔116以至少密封溶液腔111。In addition, the top of the solution cavity 111 (ie, the mouth of the cavity) and the top of the test paper cavity 112 (ie, the mouth of the cavity) are located in the second counterbore 116. Therefore, the sealing film 114 is disposed in the second counterbore 116 to seal at least the solution chamber 111.
为了进一步地提高生化试纸管100的防开启性能,如图6~7所示,盖部120还包括倒角部件123,倒角部件123设置于限位部件122的外壁并与限位部件122一体成型。在盖部120封闭管部110的情况下,倒角部件123的上端的横截面的宽度小于倒角部件123的下端的横截面的宽度。In order to further improve the anti-opening performance of the biochemical test paper tube 100, as shown in FIGS. 6-7, the cover 120 further includes a chamfering member 123, which is arranged on the outer wall of the limiting member 122 and integrated with the limiting member 122 forming. In the case where the cover 120 closes the pipe 110, the width of the cross section of the upper end of the chamfering member 123 is smaller than the width of the cross section of the lower end of the chamfering member 123.
在盖部120封闭管部110的情况下,限位部件122连通倒角部件123设置于第一沉孔115,即限位部件122的上表面、倒角部件123的上表面和第一沉孔115的上表面处于同一水平面。When the cover 120 closes the pipe 110, the limiting member 122 communicates with the chamfering member 123 and is provided in the first counterbore 115, that is, the upper surface of the limiting member 122, the upper surface of the chamfering member 123, and the first counterbore 115 The upper surface of 115 is on the same horizontal plane.
此外,为了一些情况下获取检测后的样品,如图8~9所示,管部110还包括开盖部件117,开盖部件117设置在第一沉孔115的上表面或内部,用于在特定情况下,通过开盖部件117将盖部120与管部110分离。In addition, in order to obtain samples after testing in some cases, as shown in FIGS. 8-9, the tube 110 further includes an opening member 117, which is provided on the upper surface or inside of the first counterbore 115 for Under certain circumstances, the lid 120 is separated from the pipe 110 by the lid opening member 117.
其中,开盖部件117贯穿第一沉孔115设置。具体地,开盖部件117的第一端位于第一沉孔115的内壁,开盖部件117的第二端位于第一沉孔115的外壁,通过借助辅助工具穿过开盖部件117,如撬棒,将盖部120翘起,以使盖部120与管部110分离。Wherein, the cover opening part 117 is provided through the first counterbore 115. Specifically, the first end of the lid opening member 117 is located on the inner wall of the first counterbore 115, and the second end of the lid opening member 117 is located on the outer wall of the first counterbore 115, and the lid opening member 117 is passed through with the aid of an auxiliary tool, such as a pry Use a rod to lift the lid 120 to separate the lid 120 from the tube 110.
或者,开盖部件117设置于第一沉孔115的上表面。具体地,开盖部件117的第一端位于第一沉孔115的内壁,开盖部件117的第二端位于第一沉孔115的内壁和外壁之间,通过借助辅助工具穿过开盖部件117,如撬片,将盖部120翘起,以使盖部120与管部110分离。Alternatively, the lid opening member 117 is provided on the upper surface of the first counterbore 115. Specifically, the first end of the opening member 117 is located on the inner wall of the first counterbore 115, and the second end of the opening member 117 is located between the inner wall and the outer wall of the first counterbore 115, passing through the opening member with the aid of an auxiliary tool. 117, such as an opening pick, tilts the cover 120 to separate the cover 120 from the tube 110.
本实施例的使用方法同实施例1基本相同,在此不再赘述。The usage method of this embodiment is basically the same as that of Embodiment 1, and will not be repeated here.
在本实施例中,在盖部封闭管部的情况下,在沉孔单元作用下,难以将盖部与管部分离;利用在倒角部件难以提供受力点的效果,即使外力强制作用于沉孔单元与倒角部件,也无法将盖部与管部分离;在一些情况下,可通过开盖部件将盖部与管部分离,以对生化试纸管内的溶液或物质进行回收处理In this embodiment, when the cover part closes the pipe part, it is difficult to separate the cover part from the pipe part under the action of the counterbore unit; the effect of the chamfering part that is difficult to provide a force point, even if the external force is strong The counterbore unit and the chamfering part cannot separate the cover and the tube; in some cases, the cover can be separated from the tube by the opening part to recover the solution or substance in the biochemical test paper tube.
实施例4Example 4
如图12~13所示,一种生化试纸管100,包括管部110、盖部120和连接部130,管部110和盖部120通过连接部130连接,盖部120用于对管部110进行封闭。As shown in Figures 12-13, a biochemical test paper tube 100 includes a tube portion 110, a lid portion 120, and a connecting portion 130. The tube portion 110 and the lid portion 120 are connected by the connecting portion 130. Closed.
其中,连接部130的连接关系、结构同实施例1基本相同,在此不再赘述。The connection relationship and structure of the connecting portion 130 are basically the same as those of the first embodiment, and will not be repeated here.
管部110包括溶液腔111、试纸腔112、密封平台113、密封膜114和沉孔单元,其中,溶液腔111、试纸腔112、密封膜114、沉孔单元的连接关系和结构同实施例2基本相同,在此不再赘述。The tube portion 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113, a sealing film 114, and a counterbore unit. The connection relationship and structure of the solution cavity 111, the test paper cavity 112, the sealing film 114, and the counterbore unit are the same as those of the second embodiment. It's basically the same, so I won't repeat it here.
盖部120包括空腔121、限位部件122和顶破部件124,其中,空腔121、限位部件122的连接关系和结构同实施例1基本相同,在此不再赘述。The cover 120 includes a cavity 121, a limiting member 122, and a bursting member 124. The connection relationship and structure of the cavity 121 and the limiting member 122 are basically the same as those in the first embodiment, and will not be repeated here.
顶破部件124设置于盖部120的内部,其第一端与盖部120的内底面连接,其第二端位于盖部120的开口。在盖部120未完全封闭管部110的情况下,顶破部件124的第二端接触密封膜114以破坏密封膜114。The bursting component 124 is disposed inside the cover 120, its first end is connected to the inner bottom surface of the cover 120, and its second end is located at the opening of the cover 120. In the case where the cover 120 does not completely close the pipe 110, the second end of the bursting member 124 contacts the sealing film 114 to break the sealing film 114.
其中,顶破部件124的第二端可以是钝端,也可以是尖端,也可以是刃部。其能够在接触密封膜114的情况下,顶破密封膜114。Wherein, the second end of the bursting component 124 may be a blunt end, a pointed end, or a blade part. It can break the sealing film 114 when it contacts the sealing film 114.
在顶破部件124为刃部的情况下,其刃部至少为两个,用于切割密封膜114。When the bursting member 124 is a blade portion, there are at least two blade portions for cutting the sealing film 114.
本实施例的使用方法如下:先将盖部120向管部110移动,使顶破部件124接触并破坏密封膜114,以露出溶液腔111;将待检测样品,如咽拭子放入溶液腔111内;将盖部120封闭管部110,并使盖部120的限位部件121没入第一沉孔115内;待溶液腔111内反应完全后,将生化试纸管100倾斜,使反应溶液接触试纸腔112内的免疫层析试纸,反应溶液在免疫层析试纸上进行层析作用,通过观察免疫层析试纸即可获知检测结果;在观察到检测结果之后,可以直接将生化试纸管100当做医疗废弃物处理,无须担忧生化试纸管100内的物质泄漏。The method of use in this embodiment is as follows: first move the cover 120 to the tube 110 so that the bursting part 124 contacts and breaks the sealing film 114 to expose the solution cavity 111; put the sample to be tested, such as a throat swab, into the solution cavity 111; the cap 120 is closed to the tube 110, and the limiting component 121 of the cap 120 is immersed in the first counterbore 115; after the reaction in the solution chamber 111 is complete, the biochemical test paper tube 100 is tilted to make the reaction solution contact The immunochromatographic test paper in the test paper cavity 112, the reaction solution is chromatographed on the immunochromatographic test paper, and the test result can be obtained by observing the immunochromatographic test paper; after the test result is observed, the biochemical test paper tube 100 can be directly used as There is no need to worry about the leakage of the material in the biochemical test paper tube 100 in the treatment of medical waste.
在本实施例中,在盖部设置顶破部件用于破坏密封膜,降低人工破坏密封膜造成污染的概率,提高检测结果的准确性。In this embodiment, a bursting component is provided on the cover to destroy the sealing film, reducing the probability of pollution caused by artificially destroying the sealing film, and improving the accuracy of the detection result.
实施例5Example 5
如图14~15所示,一种生化试纸管100,包括管部110、盖部120和连接部130,管部110和 盖部120通过连接部130连接,盖部120用于对管部110进行封闭。As shown in Figures 14-15, a biochemical test paper tube 100 includes a tube portion 110, a lid portion 120, and a connecting portion 130. The tube portion 110 and the lid portion 120 are connected by the connecting portion 130. Closed.
其中,连接部130的连接关系、结构同实施例1基本相同,在此不再赘述。The connection relationship and structure of the connecting portion 130 are basically the same as those of the first embodiment, and will not be repeated here.
管部110包括溶液腔111、试纸腔112、密封平台113、密封膜114、沉孔单元和第一嵌合部件118,其中,溶液腔111、试纸腔112、密封膜114、沉孔单元的连接关系和结构同实施例2基本相同,在此不再赘述。The tube portion 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113, a sealing film 114, a counterbore unit and a first fitting part 118, wherein the solution cavity 111, the test paper cavity 112, the sealing film 114, and the connection of the counterbore unit The relationship and structure are basically the same as those in Embodiment 2, and will not be repeated here.
第一嵌合部件118设置于管部110的顶部的内壁,第一嵌合部件118沿管部110的轴向间隔设置。The first fitting members 118 are provided on the inner wall of the top of the pipe portion 110, and the first fitting members 118 are arranged at intervals along the axial direction of the pipe portion 110.
具体地,第一嵌合部件118设置于第二沉孔116的内壁,第一嵌合部件118沿第二沉孔116的轴向间隔设置。Specifically, the first fitting part 118 is arranged on the inner wall of the second counterbore 116, and the first fitting part 118 is arranged at intervals along the axial direction of the second counterbore 116.
盖部120包括空腔121、限位部件122、顶破部件124、密封部件125和第二嵌合部件126,其中,空腔121、限位部件122、顶破部件124的连接关系和结构同实施例3基本相同,在此不再赘述。The cover 120 includes a cavity 121, a limiting component 122, a bursting component 124, a sealing component 125, and a second fitting component 126, wherein the connection relationship and structure of the cavity 121, the limiting component 122, and the bursting component 124 are the same Embodiment 3 is basically the same and will not be repeated here.
密封部件125和第二嵌合部件126沿盖部120的轴向间隔设置。在盖部120封闭管部110的情况下,密封部件125位于盖部120的下侧,第二嵌合部件126位于密封部件125的上侧。The sealing member 125 and the second fitting member 126 are spaced apart in the axial direction of the cover 120. When the lid 120 closes the pipe 110, the sealing member 125 is located on the lower side of the lid 120, and the second fitting member 126 is located on the upper side of the sealing member 125.
在盖部120封闭管部110的情况下,密封部件125与管部110进行密封,第二嵌合部件126与第一嵌合部件118嵌合连接,以使盖部120与管部110进行紧密连接。When the lid 120 closes the tube 110, the sealing member 125 seals the tube 110, and the second fitting member 126 is fitted and connected to the first fitting member 118 so that the lid 120 and the tube 110 are tightly connected. connect.
在其中的一个实施例中,密封部件125为环形凸起,其外径与管部110的第二沉孔116的内径相等。In one of the embodiments, the sealing member 125 is an annular protrusion whose outer diameter is equal to the inner diameter of the second counterbore 116 of the tube portion 110.
在其中的一个实施例中,第一嵌合部件118为环形凹槽;第二嵌合部件126为环形凸起,其外径大于管部110的第二沉孔116的的内径,并与第一嵌合部件118相紧密配合。In one of the embodiments, the first fitting part 118 is an annular groove; the second fitting part 126 is an annular protrusion, the outer diameter of which is larger than the inner diameter of the second counterbore 116 of the tube portion 110, and is compared with the first A fitting part 118 fits tightly.
通过本实施例的密封部件、第一嵌合部件和第二嵌合部件,进一步地提高盖部与管部之间连接的紧密程度,极大地提高了将盖部与管部分离的阻力,有效防止生化试纸管内的溶液泄漏,避免污染环境,防止危害生命健康。Through the sealing part, the first fitting part and the second fitting part of this embodiment, the tightness of the connection between the cover part and the pipe part is further improved, and the resistance to separate the cover part and the pipe part is greatly improved, which is effective Prevent leakage of the solution in the biochemical test paper tube, avoid polluting the environment, and prevent endangering life and health.
实施例6Example 6
本实施例涉及放置在实施例1~4的生化试纸管中的生化试纸。This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
在本实施例中,以生化试纸为免疫层析试纸为例进行说明。In this embodiment, the biochemical test paper is an immunochromatographic test paper as an example for description.
如图16~18所示,一种生化试纸200,包括基材210、层析膜220、吸水垫230、结合垫240和导引膜250,其中,导引膜250、结合垫240、层析膜220和吸水垫230依次设置在基材210。As shown in Figures 16-18, a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, a water-absorbing pad 230, a bonding pad 240, and a guiding membrane 250, wherein the guiding membrane 250, the binding pad 240, and the chromatographic membrane The film 220 and the water absorbing pad 230 are sequentially arranged on the substrate 210.
其中,生化试纸200的长度大于试纸腔112的高度。一般而言,生化试纸200的长度与试纸 腔112的高度之间的差值为1mm~5mm,优选的的差值为2mm、3mm。The length of the biochemical test paper 200 is greater than the height of the test paper cavity 112. Generally speaking, the difference between the length of the biochemical test paper 200 and the height of the test paper cavity 112 is 1 mm to 5 mm, and the preferable difference is 2 mm and 3 mm.
此外,在盖部120封闭管部110的情况下,生化试纸200的样品溶液接收端伸入盖部120的空腔122内。In addition, when the lid 120 closes the tube 110, the sample solution receiving end of the biochemical test paper 200 extends into the cavity 122 of the lid 120.
基材210由塑料制成,如不干胶塑料。The substrate 210 is made of plastic, such as self-adhesive plastic.
导引膜250设置在基材210的上表面,即导引膜250的下表面和基材210的上表面连接,如粘接。导引膜250的末端和结合垫240的前端接触,导引膜250向结合垫240传递溶液。The guiding film 250 is disposed on the upper surface of the substrate 210, that is, the lower surface of the guiding film 250 and the upper surface of the substrate 210 are connected, such as by bonding. The end of the guiding film 250 is in contact with the front end of the bonding pad 240, and the guiding film 250 transfers the solution to the bonding pad 240.
导引膜250的末端的上表面和结合垫240的前端的下表面接触,或,导引膜250的末端的下表面和结合垫240的前端的上表面接触。The upper surface of the end of the guiding film 250 is in contact with the lower surface of the front end of the bonding pad 240, or the lower surface of the end of the guiding film 250 is in contact with the upper surface of the front end of the bonding pad 240.
其中,导引膜250由纤维素膜制成。Among them, the guiding film 250 is made of cellulose film.
其中,导引膜250的厚度小于0.15mm。Wherein, the thickness of the guiding film 250 is less than 0.15 mm.
结合垫240设置在基材210的上表面,即结合垫240的下表面和基材210的上表面连接,如粘接。结合垫240的末端和层析膜220的前端接触,结合垫240向层析膜220传递溶液。具体地,结合垫240的末端的上表面和层析膜220的前端的下表面接触,或,结合垫240的末端的下表面和层析膜220的前端的上表面接触。The bonding pad 240 is disposed on the upper surface of the substrate 210, that is, the lower surface of the bonding pad 240 and the upper surface of the substrate 210 are connected, such as by bonding. The end of the bonding pad 240 is in contact with the front end of the chromatography membrane 220, and the bonding pad 240 transfers the solution to the chromatography membrane 220. Specifically, the upper surface of the end of the bonding pad 240 is in contact with the lower surface of the front end of the chromatography membrane 220, or the lower surface of the end of the bonding pad 240 is in contact with the upper surface of the front end of the chromatography membrane 220.
其中,结合垫240为胶体金垫。Among them, the bonding pad 240 is a colloidal gold pad.
其中,结合垫240由玻璃纤维、聚酯膜、纤维素滤纸、无纺布等材质制成。Wherein, the bonding pad 240 is made of glass fiber, polyester film, cellulose filter paper, non-woven fabric and other materials.
其中,导引膜250的溶液层析速度小于结合垫240的溶液层析速度。The solution chromatography speed of the guiding membrane 250 is lower than the solution chromatography speed of the bonding pad 240.
层析膜220至少设置在基材210的上表面,即层析膜220的下表面和基材210的上表面连接,如粘接。层析膜220的末端和吸水垫230的末端接触,层析膜220向吸水垫230传递溶液。The chromatographic membrane 220 is disposed at least on the upper surface of the substrate 210, that is, the lower surface of the chromatographic membrane 220 and the upper surface of the substrate 210 are connected, such as by bonding. The end of the chromatographic membrane 220 is in contact with the end of the absorbent pad 230, and the chromatographic membrane 220 transfers the solution to the absorbent pad 230.
其中,层析膜220还设置有检测线221和质控线222,沿着层析膜220的前端至末端依次设置。Wherein, the chromatographic membrane 220 is further provided with a detection line 221 and a quality control line 222, which are sequentially arranged along the front end to the end of the chromatographic membrane 220.
其中,层析膜220由硝酸纤维素膜制成。Among them, the chromatography membrane 220 is made of nitrocellulose membrane.
吸水垫230至少设置在基材210的下表面,即吸水垫230的上表面和基材210的下表面连接,如粘接。吸水垫230的末端和层析膜220的末端接触。The absorbent pad 230 is disposed at least on the bottom surface of the substrate 210, that is, the top surface of the absorbent pad 230 and the bottom surface of the substrate 210 are connected, such as by bonding. The end of the absorbent pad 230 is in contact with the end of the chromatography membrane 220.
其中,吸水垫230为吸水纸。Among them, the absorbent pad 230 is absorbent paper.
其中,层析膜220的末端和吸水垫230的末端在基材210的末端接触并进行溶液传递。Wherein, the end of the chromatographic membrane 220 and the end of the absorbent pad 230 are in contact with the end of the substrate 210 and the solution is transferred.
在本实施例的第一个实施方式中,层析膜220的末端超出基材210的末端一定距离,吸水垫230的末端超出基材210的末端一定距离,层析膜220的末端和吸水垫230的末端接触并进行溶液传递,即层析膜220的末端的下表面和吸水垫230的末端的上表面接触并进行溶液传递。在这 种实施方式中,层析膜220、基材210和吸水垫230形成一个三明治结构。In the first implementation of this embodiment, the end of the chromatography membrane 220 exceeds the end of the substrate 210 by a certain distance, the end of the absorbent pad 230 exceeds the end of the substrate 210 by a certain distance, and the end of the chromatography membrane 220 and the absorbent pad The end of 230 contacts and performs solution transfer, that is, the lower surface of the end of the chromatography membrane 220 and the upper surface of the end of the absorbent pad 230 contact and transfer the solution. In this embodiment, the chromatography membrane 220, the substrate 210, and the absorbent pad 230 form a sandwich structure.
在本实施例的第二个实施方式中,层析膜220还设置在基材210的下表面,即层析膜220的末端在基材210的末端向下弯折。具体地,层析膜220的末端的上表面和吸水垫230的末端的上表面接触并进行溶液传递,或层析膜220的末端的下表面和吸水垫230的末端的下表面接触并进行溶液传递。In the second implementation of this embodiment, the chromatography membrane 220 is also disposed on the lower surface of the substrate 210, that is, the end of the chromatography membrane 220 is bent downward at the end of the substrate 210. Specifically, the upper surface of the end of the chromatography membrane 220 is in contact with the upper surface of the end of the absorbent pad 230 and the solution is transferred, or the lower surface of the end of the chromatography membrane 220 is in contact with the lower surface of the end of the absorbent pad 230 and the solution is transferred. transfer.
在该实施方式中,位于基材210的上表面的层析膜220的长度大于位于基材210的下表面的层析膜220的长度;或者,位于基材210的上表面的层析膜220的长度等于位于基材210的下表面的层析膜220的长度;或者,位于基材210的上表面的层析膜220的长度小于位于基材210的下表面的层析膜220的长度。In this embodiment, the length of the chromatography membrane 220 located on the upper surface of the substrate 210 is greater than the length of the chromatography membrane 220 located on the lower surface of the substrate 210; or, the chromatography membrane 220 located on the upper surface of the substrate 210 The length of is equal to the length of the chromatography membrane 220 on the lower surface of the substrate 210; or, the length of the chromatography membrane 220 on the upper surface of the substrate 210 is less than the length of the chromatography membrane 220 on the lower surface of the substrate 210.
优选地,位于基材210的上表面的层析膜220的长度大于位于基材210的下表面的层析膜220的长度Preferably, the length of the chromatography membrane 220 located on the upper surface of the substrate 210 is greater than the length of the chromatography membrane 220 located on the lower surface of the substrate 210
在本实施例的第三个实施方式中,吸水垫230还设置在基材210的上表面,即吸水垫230的末端在基材210的末端向上弯折。具体地,吸水垫230的末端的上表面和层析膜220的末端的上表面接触并进行溶液传递,或吸水垫230的末端的下表面和层析膜220的末端的下表面接触并进行溶液传递。In the third implementation of this embodiment, the absorbent pad 230 is also disposed on the upper surface of the substrate 210, that is, the end of the absorbent pad 230 is bent upward at the end of the substrate 210. Specifically, the upper surface of the end of the absorbent pad 230 is in contact with the upper surface of the end of the chromatography membrane 220 and the solution is transferred, or the lower surface of the end of the absorbent pad 230 is in contact with the lower surface of the end of the chromatography membrane 220 and the solution is transferred. transfer.
在该实施方式中,位于基材210的上表面的吸水垫230的长度大于位于基材210的下表面的吸水垫230的长度;或者,位于基材210的上表面的吸水垫230的长度等于位于基材210的下表面的吸水垫230的长度;或者,位于基材210的上表面的吸水垫230的长度小于位于基材210的下表面的吸水垫230的长度。In this embodiment, the length of the absorbent pad 230 on the upper surface of the substrate 210 is greater than the length of the absorbent pad 230 on the lower surface of the substrate 210; or, the length of the absorbent pad 230 on the upper surface of the substrate 210 is equal to The length of the absorbent pad 230 on the bottom surface of the substrate 210; or, the length of the absorbent pad 230 on the top surface of the substrate 210 is less than the length of the absorbent pad 230 on the bottom surface of the substrate 210.
优选地,位于基材210的上表面的吸水垫230的长度小于位于基材210的下表面的吸水垫230的长度。Preferably, the length of the absorbent pad 230 on the upper surface of the substrate 210 is smaller than the length of the absorbent pad 230 on the lower surface of the substrate 210.
此外,为了确保层析膜220的末端和吸水垫230的末端接触,在层析膜220的末端和吸水垫230的末端还设置有薄膜。薄膜包覆层析膜220和吸水垫230,以使层析膜220和吸水垫230保持接触。In addition, in order to ensure that the end of the chromatography membrane 220 and the end of the absorbent pad 230 are in contact, a thin film is also provided at the end of the chromatography membrane 220 and the end of the absorbent pad 230. The thin film covers the chromatographic membrane 220 and the absorbent pad 230 to keep the chromatographic membrane 220 and the absorbent pad 230 in contact.
在本实施例中,生化试纸200的长度为2cm~4cm,优选的为2.8cm、3.0cm、3.2cm、3.5cm。In this embodiment, the length of the biochemical test paper 200 is 2 cm to 4 cm, preferably 2.8 cm, 3.0 cm, 3.2 cm, 3.5 cm.
实施例7Example 7
本实施例涉及放置在实施例1~4的生化试纸管中的生化试纸。This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
在本实施例中,以生化试纸为免疫层析试纸为例进行说明。In this embodiment, the biochemical test paper is an immunochromatographic test paper as an example for description.
如图19~20所示,一种生化试纸200,包括基材210、层析膜220、吸水垫230、结合垫240、 导引膜250和样品垫260,其中,样品垫260、导引膜250、结合垫240、层析膜220和吸水垫230设置在基材210。As shown in Figures 19-20, a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, an absorbent pad 230, a bonding pad 240, a guiding film 250, and a sample pad 260, wherein the sample pad 260, the guiding film 250, the bonding pad 240, the chromatographic membrane 220 and the absorbent pad 230 are arranged on the substrate 210.
其中,基材210、层析膜220、吸水垫230和结合垫240连接关系、结构和构成同实施例1基本相同,在此不再赘述。Among them, the connection relationship, structure and composition of the substrate 210, the chromatographic membrane 220, the water-absorbing pad 230 and the bonding pad 240 are basically the same as those in Embodiment 1, and will not be repeated here.
样品垫260设置在基材210的上表面,即样品垫260的下表面和基材210的上表面连接,如粘接。The sample pad 260 is disposed on the upper surface of the substrate 210, that is, the lower surface of the sample pad 260 and the upper surface of the substrate 210 are connected, such as by bonding.
其中,样品垫260由玻璃纤维、聚酯膜、纤维素滤纸、无纺布等材质制成。Among them, the sample pad 260 is made of glass fiber, polyester film, cellulose filter paper, non-woven fabric and other materials.
在本实施例的第一个实施方式中,样品垫260的末端和导引膜250的前端接触,样品垫260向导引膜250传递溶液。具体地,样品垫260的末端的上表面和导引膜250的前端的下表面接触,或,样品垫260的末端的下表面和导引膜250的前端的上表面接触。In the first implementation of this embodiment, the end of the sample pad 260 is in contact with the front end of the guiding film 250, and the sample pad 260 transfers the solution to the guiding film 250. Specifically, the upper surface of the end of the sample pad 260 is in contact with the lower surface of the front end of the guide film 250, or the lower surface of the end of the sample pad 260 is in contact with the upper surface of the front end of the guide film 250.
在本实施例的第二个实施方式中,样品垫260的前端与导引膜250的末端接触,导引膜250向样品垫260传递溶液。具体地,导引膜250的末端的上表面和样品垫260的前端的下表面接触,或,导引膜250的末端的下表面和样品垫260的前端的上表面接触。In the second implementation of this embodiment, the front end of the sample pad 260 is in contact with the end of the guiding film 250, and the guiding film 250 transfers the solution to the sample pad 260. Specifically, the upper surface of the end of the guiding film 250 is in contact with the lower surface of the front end of the sample pad 260, or the lower surface of the end of the guiding film 250 is in contact with the upper surface of the front end of the sample pad 260.
样品垫260的末端与结合垫240的前端接触,样品垫260向结合垫240传递溶液。具体地,样品垫260的末端的上表面和结合垫240的前端的下表面接触,或,样品垫260的末端的下表面和结合垫240的前端的上表面接触。The end of the sample pad 260 is in contact with the front end of the bonding pad 240, and the sample pad 260 transfers the solution to the bonding pad 240. Specifically, the upper surface of the end of the sample pad 260 is in contact with the lower surface of the front end of the bonding pad 240, or the lower surface of the end of the sample pad 260 is in contact with the upper surface of the front end of the bonding pad 240.
在本实施例的第三个实施方式中,免疫层析试纸包括两个导引膜250分别设置在样品垫260的前侧和后侧,即第一个导引膜250的末端与样品垫260的前端接触,第一个导引膜250向样品垫260传递溶液。具体地,第一个导引膜250的末端的上表面和样品垫260的前端的下表面接触,或,第一个导引膜250的末端的下表面和样品垫260的前端的上表面接触。In the third implementation of this embodiment, the immunochromatographic test paper includes two guiding films 250 respectively arranged on the front and back sides of the sample pad 260, that is, the end of the first guiding film 250 and the sample pad 260 The first guiding film 250 transfers the solution to the sample pad 260. Specifically, the upper surface of the end of the first guiding film 250 is in contact with the lower surface of the front end of the sample pad 260, or the lower surface of the end of the first guiding film 250 is in contact with the upper surface of the front end of the sample pad 260 .
样品垫260的末端与第二个导引膜250接触,样品垫260向第二个导引膜250传递溶液。样品垫260的末端的上表面和第二个导引膜250的前端的下表面接触,或,样品垫260的末端的下表面和第二个导引膜250的前端的上表面接触。The end of the sample pad 260 is in contact with the second guiding film 250, and the sample pad 260 transfers the solution to the second guiding film 250. The upper surface of the end of the sample pad 260 is in contact with the lower surface of the front end of the second guiding film 250, or the lower surface of the end of the sample pad 260 is in contact with the upper surface of the front end of the second guiding film 250.
其中,在导引膜250仅有一个的情况下,导引膜250可以为第一导引膜;在导引膜250为两个的情况下,靠近层析膜220的导引膜250可以为第一导引膜,远离层析膜220的导引膜250可以为第二导引膜。Wherein, in the case where there is only one guiding membrane 250, the guiding membrane 250 may be the first guiding membrane; when there are two guiding membranes 250, the guiding membrane 250 close to the chromatographic membrane 220 may be The first guiding membrane, and the guiding membrane 250 away from the chromatographic membrane 220 may be the second guiding membrane.
在本实施例中,样品垫260的溶液层析速度大于导引膜250的溶液层析速度。In this embodiment, the solution chromatography speed of the sample pad 260 is greater than the solution chromatography speed of the guiding membrane 250.
在本实施例中,生化试纸200的长度为2cm~4cm,优选的为3.2cm、3.5cm。In this embodiment, the length of the biochemical test paper 200 is 2 cm to 4 cm, preferably 3.2 cm, 3.5 cm.
实施例8Example 8
本实施例涉及放置在实施例1~4的生化试纸管中的生化试纸。This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
在本实施例中,以生化试纸为免疫层析试纸为例进行说明。In this embodiment, the biochemical test paper is an immunochromatographic test paper as an example for description.
如图21~22所示,一种生化试纸200,包括基材210、层析膜220、吸水垫230、结合垫240、导引膜250和样品限量膜270,其中,样品限量膜270、导引膜250、结合垫240、层析膜220和吸水垫230依次设置在基材210。As shown in Figures 21-22, a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, a water-absorbing pad 230, a bonding pad 240, a guiding film 250, and a sample limit film 270, wherein the sample limit film 270, the guide film The guiding film 250, the bonding pad 240, the chromatographic film 220 and the water absorption pad 230 are sequentially arranged on the substrate 210.
其中,基材210、层析膜220、吸水垫230、结合垫240和导引膜250的连接关系、结构和构成同实施例5基本相同,在此不再赘述。Among them, the connection relationship, structure and composition of the substrate 210, the chromatographic membrane 220, the water-absorbing pad 230, the bonding pad 240 and the guiding membrane 250 are basically the same as those of Embodiment 5, and will not be repeated here.
样品限量膜270设置在基材210的上表面,即样品限量膜270的下表面与基材210的上表面连接,如粘接。样品限量膜270的末端与导引膜250的前端接触,样品限量膜270向导引膜250传递溶液。具体地,样品限量膜270的末端的上表面与导引膜250的前端的下表面接触,或,样品限量膜270的末端的下表面与导引膜250的前端的上表面接触。The sample limiting film 270 is disposed on the upper surface of the substrate 210, that is, the lower surface of the sample limiting film 270 is connected to the upper surface of the substrate 210, such as by bonding. The end of the sample limiting film 270 is in contact with the front end of the guiding film 250, and the sample limiting film 270 transfers the solution to the guiding film 250. Specifically, the upper surface of the end of the sample limiting film 270 is in contact with the lower surface of the leading end of the guiding film 250, or the lower surface of the end of the sample limiting film 270 is in contact with the upper surface of the leading end of the guiding film 250.
其中,样品限量膜270的吸液饱和容积为2~20μl,能够吸收微量样品。Wherein, the absorption saturation volume of the sample limiting membrane 270 is 2-20 μl, which can absorb a small amount of sample.
其中,样品限量膜270由玻璃纤维、聚酯膜、纤维素滤纸等材质制成。Among them, the sample limit film 270 is made of glass fiber, polyester film, cellulose filter paper and other materials.
在本实施例中,生化试纸200的长度为2cm~4cm,优选的为3.3cm、3.5cm、3.7cm。In this embodiment, the length of the biochemical test paper 200 is 2 cm to 4 cm, preferably 3.3 cm, 3.5 cm, 3.7 cm.
实施例9Example 9
本实施例涉及放置在实施例1~4的生化试纸管中的生化试纸。This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
在本实施例中,以生化试纸为免疫层析试纸为例进行说明。In this embodiment, the biochemical test paper is an immunochromatographic test paper as an example for description.
如图23~24所示,一种生化试纸200,包括基材210、层析膜220、吸水垫230、结合垫240、导引膜250、样品垫260和样品限量膜270,其中,样品限量膜270、导引膜250、样品垫260、结合垫240、层析膜220和吸水垫230设置在基材210。As shown in Figures 23-24, a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, an absorbent pad 230, a bonding pad 240, a guiding membrane 250, a sample pad 260, and a sample limit film 270. The sample limit The membrane 270, the guiding membrane 250, the sample pad 260, the bonding pad 240, the chromatographic membrane 220 and the water absorption pad 230 are arranged on the substrate 210.
其中,基材210、层析膜220、吸水垫230、结合垫240、导引膜250和样品垫260的连接关系、结构和构成同实施例6的第二个实施方式、第三个实施方式基本相同,在此不再赘述。Among them, the connection relationship, structure and composition of the substrate 210, the chromatographic membrane 220, the absorbent pad 230, the bonding pad 240, the guiding membrane 250 and the sample pad 260 are the same as those of the second embodiment and the third embodiment of Example 6. It's basically the same, so I won't repeat it here.
样品限量膜270设置在基材210的上表面,即样品限量膜270的下表面与基材210的上表面连接,如粘接。样品限量膜270的末端与导引膜250的前端接触,样品限量膜270向导引膜250传递溶液。具体地,样品限量膜270的末端的上表面与导引膜250的前端的下表面接触,或,样品限量膜270的末端的下表面与导引膜250的前端的上表面接触。The sample limiting film 270 is disposed on the upper surface of the substrate 210, that is, the lower surface of the sample limiting film 270 is connected to the upper surface of the substrate 210, such as by bonding. The end of the sample limiting film 270 is in contact with the front end of the guiding film 250, and the sample limiting film 270 transfers the solution to the guiding film 250. Specifically, the upper surface of the end of the sample limiting film 270 is in contact with the lower surface of the leading end of the guiding film 250, or the lower surface of the end of the sample limiting film 270 is in contact with the upper surface of the leading end of the guiding film 250.
其中,样品限量膜270的吸液饱和容积为2~20μl,能够吸收微量样品。Wherein, the absorption saturation volume of the sample limiting membrane 270 is 2-20 μl, which can absorb a small amount of sample.
其中,样品限量膜270由玻璃纤维、聚酯膜、纤维素滤纸等材质制成。Among them, the sample limit film 270 is made of glass fiber, polyester film, cellulose filter paper and other materials.
在本实施例中,生化试纸200的长度为2cm~4cm,优选的为3.6cm、3.8cm。In this embodiment, the length of the biochemical test paper 200 is 2 cm to 4 cm, preferably 3.6 cm or 3.8 cm.
实施例10Example 10
本实施例涉及放置在实施例1~4的生化试纸管中的生化试纸。This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
在本实施例中,以生化试纸为免疫层析试纸为例进行说明。如图25所示,一种生化试纸200,包括基材210、层析膜220、吸水垫230、结合垫240、导引膜250和透明保护膜280,其中,导引膜250、结合垫240、层析膜220和吸水垫230依次设置在基材210。In this embodiment, the biochemical test paper is an immunochromatographic test paper as an example for description. As shown in FIG. 25, a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, a water-absorbing pad 230, a bonding pad 240, a guiding film 250, and a transparent protective film 280, wherein the guiding film 250 and the bonding pad 240 , The chromatographic membrane 220 and the absorbent pad 230 are sequentially arranged on the substrate 210.
其中,基材210、层析膜220、吸水垫230、结合垫240和导引膜250的连接关系、结构和构成同实施例1基本相同,在此不再赘述。Among them, the connection relationship, structure and composition of the substrate 210, the chromatographic membrane 220, the water-absorbing pad 230, the bonding pad 240 and the guiding membrane 250 are basically the same as those of Embodiment 1, and will not be repeated here.
透明保护膜280的下表面至少覆盖结合垫240和层析膜220。The lower surface of the transparent protective film 280 covers at least the bonding pad 240 and the chromatography film 220.
在本实施例中,利用透明保护膜280可以避免结合垫240和层析膜220的接触外源性含水混合物,提高层析试纸的检测结果的正确率。In this embodiment, the use of the transparent protective film 280 can prevent the bonding pad 240 and the chromatography film 220 from contacting the exogenous aqueous mixture, and improve the accuracy of the detection result of the chromatography test paper.
此外,透明保护膜280还可以应用在实施例6~实施例8的生化试纸。In addition, the transparent protective film 280 can also be applied to the biochemical test papers of Examples 6-8.
实施例11Example 11
如图26所示,生化试纸200还包括透明中空管300,透明中空管300包裹生化试纸200于透明中空管300的内部,即生化试纸200设置于透明中空管300的内部。As shown in FIG. 26, the biochemical test paper 200 further includes a transparent hollow tube 300. The transparent hollow tube 300 wraps the biochemical test paper 200 inside the transparent hollow tube 300, that is, the biochemical test paper 200 is disposed inside the transparent hollow tube 300.
透明中空管300的内表面为疏水表面。The inner surface of the transparent hollow tube 300 is a hydrophobic surface.
透明中空管300的第一端为封闭端,其第二端为开口端,设置开口端的目的是便于将生化试纸200从开口向透明中空管300的内部移动。The first end of the transparent hollow tube 300 is a closed end, and the second end is an open end. The purpose of setting the open end is to facilitate the movement of the biochemical test paper 200 from the opening to the inside of the transparent hollow tube 300.
此外,生化试纸200的样品溶液接收端位于透明中空管300的开口端。In addition, the sample solution receiving end of the biochemical test paper 200 is located at the open end of the transparent hollow tube 300.
其中,透明中空管300由透明材料制成,如塑料、热塑性树脂,便于观察生化试纸200的检测或诊断结果。Wherein, the transparent hollow tube 300 is made of a transparent material, such as plastic or thermoplastic resin, which is convenient for observing the detection or diagnosis result of the biochemical test paper 200.
在其中的一个实施例中,如图27所示,透明中空管300的开口端的第二端的横截面的宽度大于开口端的第一端的横截面的内径。优选地,透明中空管300的开口端的横截面的宽度由开口端的第二端向开口端的第一端递减。In one of the embodiments, as shown in FIG. 27, the width of the cross section of the second end of the open end of the transparent hollow tube 300 is larger than the inner diameter of the cross section of the first end of the open end. Preferably, the width of the cross section of the open end of the transparent hollow tube 300 decreases from the second end of the open end to the first end of the open end.
如图28所示,将套设有透明中空管300的生化试纸200放入生化试纸管100的试纸腔112,可以避免生化试纸200直接与试纸腔112的内表面接触,防止试纸腔112的内表面的表面张力影响生化试纸200的吸附速率。As shown in Figure 28, putting the biochemical test paper 200 covered with a transparent hollow tube 300 into the test paper cavity 112 of the biochemical test paper tube 100 can prevent the biochemical test paper 200 from directly contacting the inner surface of the test paper cavity 112 and prevent the test paper cavity 112 from being damaged. The surface tension of the inner surface affects the adsorption rate of the biochemical test paper 200.
以上所述仅为本发明较佳的实施例,并非因此限制本发明的实施方式及保护范围,对于本领域技术人员而言,应当能够意识到凡运用本发明说明书及图示内容所作出的等同替换和显而易见的变化所得到的方案,均应当包含在本发明的保护范围内。The above descriptions are only preferred embodiments of the present invention, and do not limit the implementation and protection scope of the present invention. For those skilled in the art, they should be able to realize that all equivalents made by using the description and illustrations of the present invention are equivalent. The solutions obtained by substitutions and obvious changes should all be included in the protection scope of the present invention.

Claims (15)

  1. 一种生化试纸管,包括管部和盖部,其特征在于,所述管部包括:A biochemical test paper tube, comprising a tube part and a cover part, characterized in that the tube part comprises:
    溶液腔,所述溶液腔的顶部端面设置有密封平台,所述密封平台全部地环绕所述溶液腔设置,所述管口的内径为所述管部的最大内径;A solution cavity, a sealing platform is arranged on the top end surface of the solution cavity, the sealing platform is arranged all around the solution cavity, and the inner diameter of the nozzle is the maximum inner diameter of the pipe;
    试纸腔,用于容纳放置生化试纸;Test paper cavity, used to hold biochemical test paper;
    在所述盖部封闭所述管部的情况下,所述密封平台以及所述试纸腔的顶部与所述盖部的底部具有一定距离。When the cover part closes the tube part, the sealing platform and the top of the test paper cavity have a certain distance from the bottom of the cover part.
  2. 根据权利要求1所述的生化试纸管,其特征在于,所述试纸腔的顶部端面低于所述管部的顶部端面。The biochemical test paper tube according to claim 1, wherein the top end surface of the test paper cavity is lower than the top end surface of the tube portion.
  3. 根据权利要求1所述的生化试纸管,其特征在于,所述密封平台的外边缘与所述管部的管壁之间具有一定的间隔距离,所述密封平台高出所述管壁的底面且具有一定的垂直距离。The biochemical test paper tube according to claim 1, wherein there is a certain separation distance between the outer edge of the sealing platform and the tube wall of the tube portion, and the sealing platform is higher than the bottom surface of the tube wall. And has a certain vertical distance.
  4. 根据权利要求1~3任一所述的生化试纸管,其特征在于,所述管部还包括:The biochemical test paper tube according to any one of claims 1 to 3, wherein the tube part further comprises:
    密封膜,所述密封膜与所述密封平台连接以密封所述溶液腔。The sealing film is connected with the sealing platform to seal the solution cavity.
  5. 根据权利要求1~4任一所述的生化试纸管,其特征在于,生化试纸管所述盖部与所述管部相连。The biochemical test paper tube according to any one of claims 1 to 4, wherein the cover part of the biochemical test paper tube is connected to the tube part.
  6. 根据权利要求1~5任一所述的生化试纸管,其特征在于,所述盖部包括:The biochemical test paper tube according to any one of claims 1 to 5, wherein the cover part comprises:
    空腔,所述空腔由所述盖部的内表面向外凸起形成。A cavity is formed by the inner surface of the cover portion bulging outward.
  7. 根据权利要求1~6任一所述的生化试纸管,其特征在于,所述管部还包括:The biochemical test paper tube according to any one of claims 1 to 6, wherein the tube part further comprises:
    沉孔单元,所述沉孔单元设置于所述管部的管口的顶部;A counterbore unit, the counterbore unit being arranged on the top of the nozzle of the pipe part;
    其中,在所述盖部封闭所述管部的情况下,所述盖部与所述沉孔单元配合。Wherein, when the cover part closes the tube part, the cover part cooperates with the counterbore unit.
  8. 根据权利要求7所述的生化试纸管,其特征在于,所述沉孔单元包括:The biochemical test paper tube according to claim 7, wherein the counterbore unit comprises:
    第一沉孔,所述第一沉孔设置于所述管部的管口的顶部;A first counterbore, the first counterbore being arranged at the top of the nozzle of the pipe part;
    第二沉孔,所述第二沉孔设置于所述第一沉孔的下侧;A second counterbore, the second counterbore being arranged on the lower side of the first counterbore;
    其中,所述第一沉孔的横截面的宽度大于所述第二沉孔的横截面的宽度。Wherein, the width of the cross section of the first counterbore is greater than the width of the cross section of the second counterbore.
  9. 根据权利要求7或8所述的生化试纸管,其特征在于,所述盖部还包括:The biochemical test paper tube according to claim 7 or 8, wherein the cover part further comprises:
    倒角部件,所述倒角部件设置于所述盖部的外壁;A chamfering part, the chamfering part is arranged on the outer wall of the cover;
    其中,在所述盖部封闭所述管部的情况下,所述倒角部件与所述沉孔单元配合。Wherein, when the cover part closes the tube part, the chamfering member is matched with the counterbore unit.
  10. 根据权利要求1~9任一所述的生化试纸管,其特征在于,所述盖部还包括:The biochemical test paper tube according to any one of claims 1-9, wherein the cover part further comprises:
    顶破部件,所述顶破部件设置与所述盖部的内部;A bursting component, the bursting component is arranged inside the cover;
    其中,在所述盖部封闭所述管部的情况下,所述顶破部件破坏所述密封膜。Wherein, when the cover part closes the tube part, the bursting member destroys the sealing film.
  11. 根据权利要求1~10任一所述的生化试纸管,其特征在于,所述管部还包括:The biochemical test paper tube according to any one of claims 1-10, wherein the tube part further comprises:
    第一嵌合部件,所述第一嵌合部件设置在所述管部的上部的内壁;A first fitting part, the first fitting part being arranged on the inner wall of the upper part of the tube;
    所述盖部还包括:The cover part further includes:
    密封部件,所述密封部件设置于所述盖部的外壁;A sealing member, the sealing member is arranged on the outer wall of the cover;
    第二嵌合部件,所述第二嵌合部件设置于所述盖部的外壁;A second fitting part, the second fitting part being arranged on the outer wall of the cover;
    其中,在所述盖部封闭所述管部的情况下,所述第二嵌合部件位于所述密封部件的上侧,所述第二嵌合部件与所述第一嵌合部件嵌合连接。Wherein, in the case where the cover portion closes the tube portion, the second fitting member is located on the upper side of the sealing member, and the second fitting member is fitted and connected to the first fitting member .
  12. 根据权利要求1~11任一所述的生化试纸管,其特征在于,所述生化试纸管还包括:The biochemical test paper tube according to any one of claims 1-11, wherein the biochemical test paper tube further comprises:
    生化试纸,所述生化试纸设置于所述试纸腔的内部;Biochemical test paper, the biochemical test paper is arranged inside the test paper cavity;
    其中,在所述盖部封闭所述管部的情况下,所述生化试纸的样品溶液接收端靠近所述盖部。Wherein, when the cover part closes the tube part, the sample solution receiving end of the biochemical test paper is close to the cover part.
  13. 根据权利要求12所述的生化试纸管,其特征在于,所述生化试纸的长度大于所述试纸腔的高度。The biochemical test paper tube according to claim 12, wherein the length of the biochemical test paper is greater than the height of the test paper cavity.
  14. 根据权利要求12或13所述的生化试纸管,其特征在于,所述生化试纸还包括:The biochemical test paper tube according to claim 12 or 13, wherein the biochemical test paper further comprises:
    透明中空管,所述生化试纸设置于所述透明中空管的内部,所述透明中空管设置于所述试纸腔的内部。A transparent hollow tube, the biochemical test paper is arranged inside the transparent hollow tube, and the transparent hollow tube is arranged inside the test paper cavity.
  15. 根据权利要求14所述的生化试纸管,其特征在于,所述透明中空管的一端为封闭端。The biochemical test paper tube according to claim 14, wherein one end of the transparent hollow tube is a closed end.
PCT/CN2021/101113 2020-06-19 2021-06-19 Biochemical test paper tube WO2021254514A1 (en)

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