WO2021254514A1 - Tube de papier d'essai biochimique - Google Patents

Tube de papier d'essai biochimique Download PDF

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Publication number
WO2021254514A1
WO2021254514A1 PCT/CN2021/101113 CN2021101113W WO2021254514A1 WO 2021254514 A1 WO2021254514 A1 WO 2021254514A1 CN 2021101113 W CN2021101113 W CN 2021101113W WO 2021254514 A1 WO2021254514 A1 WO 2021254514A1
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WO
WIPO (PCT)
Prior art keywords
test paper
tube
biochemical test
cavity
cover
Prior art date
Application number
PCT/CN2021/101113
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English (en)
Chinese (zh)
Inventor
喻晴
魏鹏海
周中人
Original Assignee
上海快灵生物科技有限公司
上海妙灵生物工程有限公司
上海金标生物科技有限公司
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Application filed by 上海快灵生物科技有限公司, 上海妙灵生物工程有限公司, 上海金标生物科技有限公司 filed Critical 上海快灵生物科技有限公司
Publication of WO2021254514A1 publication Critical patent/WO2021254514A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs

Definitions

  • the invention relates to the technical field of rapid detection devices, in particular to a biochemical test paper tube.
  • test tube When performing in vitro diagnosis or in vitro testing, in order to obtain qualitative results quickly, a combination of chromatography test paper and test tube is usually used as a rapid diagnostic tool or rapid detection tool. Generally speaking, the samples for diagnosis or testing usually have some dangers, such as certain toxicity and infectiousness. The used test tubes will be treated as medical waste.
  • test tube in the related art has some defects.
  • the tube part and cover part of some test tubes are of separate design, and the cover part is easy to fall off from the tube part, causing the substances and solutions in the tube part to flow outwards, polluting the environment and endangering the lives of workers.
  • the tube part and the cover part of some test tubes are designed as one-piece, but the sealing performance and connection firmness are not good. Under the action of external force, the cover part is easier to separate from the tube part, which will also cause the substance in the tube part, The solution flows outward.
  • the purpose of the present invention is to provide a biochemical test paper tube aiming at the deficiencies in the prior art.
  • the invention provides a biochemical test paper tube, comprising a tube part and a cover part, the tube part comprising:
  • a solution cavity a sealing platform is arranged on the top end surface of the solution cavity, the sealing platform is arranged all around the solution cavity, and the inner diameter of the nozzle is the maximum inner diameter of the pipe;
  • Test paper cavity used to hold biochemical test paper
  • the sealing platform and the top of the test paper cavity have a certain distance from the bottom of the cover part.
  • the top end surface of the test paper cavity is lower than the top end surface of the tube portion.
  • the cover part and the nozzle of the tube part are inserted into the fitting.
  • the horizontal distance between the sealing platform and the tube wall of the tube portion is at least 0.5 mm, and the vertical distance between the sealing platform and the tube wall is at least 0.5 mm.
  • the width of the sealing platform is at least 1 mm.
  • the distance between the sealing platform and the bottom of the cover part is at least 1 mm.
  • the tube part further includes:
  • the sealing film is connected with the sealing platform to seal the solution cavity.
  • the cover part of the biochemical test paper tube is connected to the tube part.
  • the biochemical test paper tube further includes a connecting part, and the tube part and the cover part are connected through the connecting part.
  • the cover includes:
  • a cavity is formed by the inner surface of the cover portion bulging outward.
  • the longitudinal section of the cavity is trapezoidal, circular arc or triangular.
  • the tube part further includes:
  • a counterbore unit the counterbore unit being arranged on the top of the nozzle of the pipe part;
  • the cover part when the cover part closes the tube part, the cover part cooperates with the counterbore unit.
  • the longitudinal section of the counterbore unit is stepped.
  • the counterbore unit includes:
  • a first counterbore the first counterbore being arranged at the top of the nozzle of the pipe part
  • a second counterbore the second counterbore being arranged on the lower side of the first counterbore
  • the width of the cross section of the first counterbore is greater than the width of the cross section of the second counterbore.
  • the tube part further includes:
  • the cover opening part is arranged in the first counterbore, the first end of the cover opening part is located at the inner wall of the first counterbore, and the second end of the cover opening part is located at the first counterbore.
  • the outer wall of a counterbore or is located between the outer wall of the first counterbore and the inner wall of the first counterbore.
  • the sealing film is arranged in the second counterbore and seals the solution cavity.
  • the cover further includes:
  • a chamfering part, the chamfering part is arranged on the outer wall of the cover;
  • the chamfering member is matched with the counterbore unit.
  • the tube part further includes:
  • a first fitting part the first fitting part being arranged on the inner wall of the upper part of the tube;
  • the cover part further includes:
  • a sealing member is arranged on the outer wall of the cover;
  • a second fitting part is arranged on the outer wall of the cover;
  • the second fitting member is located on the upper side of the sealing member, and the second fitting member is fitted and connected to the first fitting member .
  • the sealing member is an annular protrusion.
  • the first fitting part is an annular groove
  • the second fitting part is an annular protrusion
  • the width of the cross section of the second fitting member is smaller than the width of the cross section of the sealing member.
  • the plurality of the first fitting parts are arranged at intervals along the axial direction of the tube portion.
  • the cover further includes:
  • a bursting component is arranged inside the cover;
  • the bursting member destroys the sealing film.
  • the biochemical test paper tube further includes:
  • Biochemical test paper the biochemical test paper is arranged inside the test paper cavity
  • the sample solution receiving end of the biochemical test paper is close to the cover part.
  • the length of the biochemical test paper is greater than the height of the test paper cavity.
  • the difference between the length of the biochemical test paper and the height of the test paper cavity is 1 to 5 mm.
  • the biochemical test paper is an immunochromatography test paper
  • the immunochromatography test paper includes:
  • a chromatographic membrane is arranged on the upper surface of the substrate;
  • a water-absorbent pad, the water-absorbent pad is arranged on the lower surface of the substrate;
  • the chromatographic membrane and the water-absorbent pad are in contact with each other at the end of the substrate and transfer the solution.
  • the end of the chromatographic membrane exceeds the end of the substrate by a certain distance
  • the end of the absorbent pad exceeds the end of the substrate by a certain distance
  • the end of the chromatographic membrane is in contact with the end of the absorbent pad and transfers the solution.
  • the chromatographic membrane is also arranged on the lower surface of the substrate, and the end of the chromatographic membrane and the end of the absorbent pad are in contact with each other on the lower surface of the substrate to perform the solution. transfer.
  • the absorbent pad is also arranged on the upper surface of the substrate, and the end of the chromatographic membrane and the end of the absorbent pad are in contact on the upper surface of the substrate and transfer the solution. .
  • the immunochromatographic test paper further includes:
  • a bonding pad, the bonding pad is arranged on the substrate, the end of the bonding pad is in contact with the front end of the chromatography membrane and the solution is transferred to the chromatography membrane;
  • a guiding film the guiding film is arranged on the substrate, the end of the guiding film is in contact with the front end of the bonding pad and transferring the solution to the bonding pad;
  • the solution chromatography speed of the guiding membrane is lower than the solution chromatography speed of the binding pad.
  • the thickness of the guiding film is less than 0.15 mm.
  • the immunochromatographic test paper further includes:
  • the sample pad is arranged on the substrate, and the end of the sample pad is in contact with the front end of the guiding film and transfers the solution to the guiding film.
  • the immunochromatographic test paper further includes:
  • the sample pad is arranged on the substrate, and the end of the guiding film is in contact with the front end of the sample pad and transfers the solution to the sample pad.
  • the immunochromatographic test paper further includes:
  • a sample limiting film the sample limiting film is arranged on the substrate, the end of the sample limiting film is in contact with the front end of the guiding film, and the solution is transferred to the guiding film.
  • the absorption saturation volume of the sample limiting membrane is 2-20 ⁇ l.
  • the immunochromatographic test paper further includes:
  • the filter pad is arranged on the substrate, and the end of the guiding membrane is in contact with the front end of the filter pad and transfers the solution to the filter pad.
  • the immunochromatographic test paper further includes:
  • the water-retaining pad is arranged close to the front end of the guiding film.
  • the water-retaining pad of the immunochromatographic test paper fills the gap between the immunochromatographic test paper and the test paper fixing member.
  • the immunochromatographic test paper further includes:
  • a transparent protective film covering at least the chromatographic film and the bonding pad.
  • the chromatographic membrane includes a detection line and a quality control line arranged in sequence.
  • the lower surface of the end of the absorbent pad is in contact with the upper surface of the end of the chromatography membrane;
  • the upper surface of the end of the absorbent pad is in contact with the lower surface of the end of the chromatography membrane.
  • the lower surface of the end of the bonding pad is in contact with the upper surface of the front end of the chromatography membrane;
  • the upper surface of the end of the bonding pad is in contact with the lower surface of the front end of the chromatography membrane.
  • the lower surface of the end of the guiding film is in contact with the upper surface of the front end of the bonding pad;
  • the upper surface of the end of the guiding film is in contact with the lower surface of the front end of the bonding pad.
  • the lower surface of the end of the sample pad is in contact with the upper surface of the front end of the guiding film;
  • the upper surface of the end of the sample pad is in contact with the lower surface of the front end of the guiding film.
  • the lower surface of the end of the sample pad is in contact with the upper surface of the front end of the bonding pad
  • the upper surface of the end of the sample pad is in contact with the lower surface of the front end of the bonding pad.
  • the lower surface of the end of the guiding film is in contact with the upper surface of the front end of the sample pad;
  • the upper surface of the end of the guiding film is in contact with the lower surface of the front end of the sample pad.
  • the lower surface of the end of the guiding film is in contact with the upper surface of the front end of the filter pad;
  • the upper surface of the end of the guiding film is in contact with the lower surface of the front end of the filter pad.
  • the lower surface of the end of the filter pad is in contact with the concave surface of the front end of the bonding pad
  • the upper surface of the end of the filter pad is in contact with the lower surface of the front end of the bonding pad.
  • the lower surface of the end of the sample limiting film is in contact with the upper surface of the front end of the guiding film;
  • the upper surface of the end of the sample limiting film is in contact with the lower surface of the front end of the guiding film.
  • the length of the absorbent pad located on the upper surface of the substrate is greater than the length of the absorbent pad located on the lower surface of the substrate;
  • the length of the absorbent pad on the upper surface of the substrate is equal to the length of the absorbent pad on the lower surface of the substrate;
  • the length of the absorbent pad located on the upper surface of the substrate is less than the length of the absorbent pad located on the lower surface of the substrate.
  • the length of the chromatography membrane on the upper surface of the substrate is greater than the length of the chromatography membrane on the lower surface of the substrate;
  • the length of the chromatography membrane on the upper surface of the substrate is equal to the length of the chromatography membrane on the lower surface of the substrate;
  • the length of the chromatography membrane on the upper surface of the substrate is less than the length of the chromatography membrane on the lower surface of the substrate.
  • the detection line and the quality control line are located on the upper surface of the substrate.
  • the detection line is located on the upper surface of the substrate, and the quality control line is located on the lower surface of the substrate; or
  • the detection line and the quality control line are located on the lower surface of the substrate.
  • the biochemical test paper further includes:
  • a transparent hollow tube, the biochemical test paper is arranged inside the transparent hollow tube, and the transparent hollow tube is arranged inside the test paper cavity.
  • one end of the transparent hollow tube is a closed end.
  • the present invention adopts the above technical solutions and has the following technical effects:
  • a reaction solution is preset in the solution cavity, and a sealing film is used to seal the solution cavity.
  • a sealing film is used to seal the solution cavity.
  • Figure 1 is a cross-sectional view of an unclosed state of a biochemical test paper tube according to an embodiment of the present application (1);
  • Figure 2 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the present application (1);
  • Figure 3 is a cross-sectional view (2) of the biochemical test paper tube in an unclosed state according to an embodiment of the present application
  • FIG. 4 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the present application (2);
  • Fig. 5 is a schematic diagram (1) of the unclosed state of the biochemical test paper tube according to an embodiment of the present application
  • Figure 6 is a cross-sectional view of the biochemical test paper tube in an unclosed state according to an embodiment of the application (3);
  • Figure 7 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the application (3);
  • Figure 8 is a cross-sectional view of the biochemical test paper tube in an unclosed state according to an embodiment of the application (4);
  • Figure 9 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the present application (4);
  • FIG. 10 is a schematic diagram (2) of the unclosed state of the biochemical test paper tube according to an embodiment of the present application.
  • Figure 11 is a cross-sectional view (5) of the biochemical test paper tube in an unclosed state according to an embodiment of the present application
  • Figure 12 is a cross-sectional view of the biochemical test paper tube in an unclosed state according to an embodiment of the application (6);
  • Figure 13 is a cross-sectional view of the closed state of the biochemical test paper tube according to an embodiment of the present application (5);
  • Figure 14 is a cross-sectional view of the biochemical test paper tube in an unclosed state according to an embodiment of the present application (7);
  • Figure 16 is a schematic diagram (1) of an immunochromatographic test paper according to an embodiment of the present application.
  • Figure 17 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (1);
  • Fig. 18 is a cross-sectional view of a biochemical test paper tube according to an embodiment of the present application (with biochemical test paper);
  • Figure 19 is a schematic diagram of an immunochromatographic test paper according to an embodiment of the present application (2).
  • Figure 20 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (2);
  • Figure 21 is a schematic diagram of an immunochromatographic test paper according to an embodiment of the present application (3).
  • Figure 22 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (3);
  • Figure 23 is a schematic diagram of an immunochromatographic test paper according to an embodiment of the present application (4);
  • Figure 24 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the application (4);
  • Figure 25 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (5);
  • Figure 26 is a cross-sectional view of a transparent hollow tube according to an embodiment of the present application (1);
  • Figure 27 is a cross-sectional view of a transparent hollow tube according to an embodiment of the present application (2);
  • Fig. 28 is a cross-sectional view of a biochemical test paper tube (a biochemical test paper sheathed with a transparent hollow tube) according to an embodiment of the present application.
  • the reference signs are: 100, biochemical test paper tube; 110, tube part; 111, solution cavity; 112, test paper cavity; 113, sealing platform; 114, sealing film; 115, first counterbore; 116, second sink Hole; 117, cover opening part; 118, first fitting part; 120, cover part; 121, cavity; 122, limit part; 123, chamfering part; 124, bursting part; 125, sealing part; 126 , The second fitting part; 130, the connecting part;
  • biochemical test paper 210, substrate; 220, chromatographic membrane; 221, test line; 222, quality control line; 230, absorbent pad; 240, binding pad; 250, guiding membrane; 260, sample pad; 270, Sample limited film; 280, transparent protective film;
  • a biochemical test paper tube 100 includes a tube portion 110 and a cover portion 120, and the cover portion 120 is used to seal the tube portion 110.
  • the tube 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113 and a sealing film 114.
  • the axial direction of the solution chamber 111 is co-directed with the axial direction of the tube portion 110, and the solution chamber 111 is used for placing a solution, such as a reaction solution.
  • the axial direction of the test paper cavity 112 is parallel to the axial direction of the solution cavity 111, and the test paper cavity 112 is used for placing an immunochromatographic test paper.
  • the sealing platform 113 is arranged on the top end surface of the solution chamber 111 and is arranged all around the solution chamber 111.
  • the sealing film 114 is connected with the sealing platform 113 to seal the solution cavity 111 and prevent the solution in the solution cavity 111 from flowing out.
  • the solution cavity 111 is a regular-shaped cavity (such as a circular cavity, a rectangular cavity, and a trapezoidal cavity) or an irregular-shaped cavity.
  • the test paper cavity 112 is a regular-shaped cavity (such as a circular cavity, a rectangular cavity, and a trapezoidal cavity) or an irregular shape.
  • there may be several solution cavities 111 there may be several solution cavities 111, the axes of the several solution cavities 111 are parallel, at least one solution cavity 111 is used for placing biochemical reaction reagents or biochemical reaction solutions, and at least one solution cavity 111 is used for placing functions sexual reaction reagents.
  • functional reagents include, but are not limited to, degrading enzymes, lysis solutions, probes, buffers, diluents, etc., or reagents for subsequent reactions after the completion of the biochemical reaction.
  • test paper cavities 112 there may be several test paper cavities 112, the axes of the several test paper cavities 112 are parallel, and immunochromatographic test papers are placed in each test paper cavity 112, which can simultaneously detect different indicators of the same sample .
  • test paper cavities 112 are arranged around the axial direction of the tube 110 as a center.
  • sealing platform 113 There is a certain distance between the outer edge of the sealing platform 113 and the tube wall of the tube portion 110, and the sealing platform 113 is higher than the bottom surface of the tube wall and has a certain vertical distance.
  • the width of the sealing platform 113 is at least 1 mm; there is a certain horizontal distance between the outer wall of the sealing platform 113 and the inner wall of the pipe 110, and is at least 0.5 mm; the bottom wall of the sealing platform 113 and the inner wall of the pipe 110 are different There is a certain vertical distance between them, and at least 0.5mm.
  • the top of the sealing platform 113 does not contact the bottom of the pipe 110, that is, there is a certain vertical distance between the top of the sealing platform 113 and the bottom of the pipe 110, and is at least 1 mm .
  • top end surface of the sealing platform 113 and the top end surface of the pipe portion 110 may be located on the same horizontal plane; or, the top end surface of the sealing platform 113 is located below the top end surface of the pipe portion 110.
  • top end surface of the test paper cavity 112 is lower than the top end surface of the tube portion 110.
  • the reaction solution when leaving the factory, the reaction solution can be preset in the solution chamber 111, and then the solution chamber 111 can be sealed with the sealing film 114; or after leaving the factory, the inspector can prepare the reaction solution after getting the biochemical test paper tube 100 and The reaction solution is placed inside the solution cavity 111, and finally the solution cavity 111 is sealed with a sealing film 114, and the biochemical test paper tube 100 is stored for later use.
  • the sealing film 114 can also seal the test paper cavity 112.
  • the test paper cavity 112 can be sealed before the immunochromatography test paper is placed in the test paper cavity 112, that is, to prevent foreign matter from entering the test paper cavity 112; or the test paper cavity 112 can be sealed when the immunochromatography test paper is placed in the test paper cavity 112, that is, when the immunochromatography test paper is placed in the test paper cavity 112, Keep the immunochromatographic test paper free from external substances before use.
  • the sealing film 114 may be an aluminum foil film or a plastic film.
  • the sealing film 114 can be assembled with the biochemical test paper tube 100 during the production process, can also be assembled with the biochemical test paper tube 100 before the transportation process, or can be assembled with the biochemical test paper tube 100 before the storage process.
  • the shape of the sealing film 114 is substantially the same as the shape of the cavity at the top of the solution chamber 111, that is, the cross-sectional area of the sealing film 114 is slightly larger than the cross-sectional area of the cavity at the top of the solution cavity 111.
  • an auxiliary tool to break the sealing film 114 such as a tool with a sharp point, a blunt end, and a blade.
  • the shape of the sealing film 114 is different from the shape of the cavity opening at the top of the solution chamber 111, that is, the sealing film 114 includes a sealing part and an extension part.
  • the sealing part seals the solution chamber 111. Part of it is formed in one piece.
  • the shape of the sealing part is basically the same as the shape of the cavity opening at the top of the solution chamber 111.
  • the extension part is in a strip shape and is used to separate the sealing part from the solution chamber 111.
  • the cover 120 includes a cavity 121 formed by the inner surface of the cover 120 bulging outward, and is used to allow the solution in the solution cavity 111 to enter the cavity 121 when the biochemical test paper tube 100 is inclined. And contact with the immunochromatographic test paper in the test paper cavity 112.
  • the longitudinal section of the cavity 121 is trapezoidal, circular arc or triangular.
  • the cover 120 further includes a limiting member 122 which is provided on the outer wall of the cover 120 and is used to cooperate with the top of the tube 110 when the cover 120 closes the tube 110.
  • the limiting member 122 is an annular protrusion.
  • biochemical test paper tube 100 further includes a connecting part 130 which is connected to the tube part 110 and the cover part 120 respectively.
  • the tube portion 110, the cover portion 120, and the connecting portion 130 may be integrally connected, that is, the biochemical test paper tube 100 is a one-piece test tube.
  • the connection part 130 may be a connection bar.
  • the method of use in this embodiment is as follows: destroy or remove the sealing film 114, put the sample to be tested into the solution chamber 111, and mix the reaction solution in the solution chamber 111 with the sample to be tested to obtain a mixed solution; seal with the cover 120 Tube portion 110; After reacting for a certain period of time, tilt the tube portion 110 so that the sample solution receiving end of the immunochromatographic test paper arranged in the test paper cavity 112 contacts the mixed solution, and the mixed solution is chromatographed on the immunochromatographic test paper; The test result can be obtained by observing the immunochromatographic test paper; after observing the test result, the biochemical test paper tube 100 can be directly treated as medical waste without worrying about the leakage of the material in the biochemical test paper tube 100.
  • the biochemical test paper tube 100 includes a tube portion 110, a lid portion 120, and a connecting portion 130.
  • the tube portion 110 and the lid portion 120 are connected by the connecting portion 130. Closed.
  • the tube portion 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113, and a sealing film 114.
  • the connection relationship and structure of the solution cavity 111, the test paper cavity 112, and the sealing film 114 are basically the same as those in the first embodiment, and will not be repeated here. .
  • the cover 120 includes a cavity 121, wherein the connection relationship and structure of the cavity 121 are basically the same as those in the first embodiment, and will not be repeated here.
  • the cover 120 and the pipe 110 are externally fitted.
  • the maximum inner diameter of the cover 120 is the same as the outer diameter of the nozzle of the pipe 110, that is, the cover 120 is sleeved on the outside of the nozzle of the pipe 110.
  • a biochemical test paper tube 100 includes a tube portion 110, a cover portion 120, and a connecting portion 130.
  • the tube portion 110 and the cover portion 120 are connected by the connecting portion 130. Closed.
  • the tube portion 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113, a sealing film 114, and a counterbore unit.
  • the connection relationship and structure of the solution cavity 111, the test paper cavity 112, and the sealing film 114 are basically the same as those of the first embodiment. This will not be repeated here.
  • the counterbore unit is arranged on the top of the nozzle of the pipe 110 and is used to cooperate with the cover 120 when the cover 120 closes the pipe 110.
  • the shape of the outer wall of the cover 120 matches the shape of the inner wall of the counterbore unit. It is used to prevent the cover 120 from being removed from the counterbore unit without external force damage.
  • the longitudinal section of the counterbore unit is stepped.
  • the counterbore unit includes at least a first counterbore 115 and a second counterbore 116.
  • the first counterbore 115 is provided at the top of the nozzle of the pipe portion 110, and the second counterbore 116 is provided under the first counterbore 115. side.
  • the limiting member 122 of the lid 120 cooperates with the first counterbore 115 of the tube 110, so that the upper surface of the limiting member 122 and the upper surface of the first counterbore 115 Located on the same level.
  • Using this method of cooperation improves the anti-opening performance of the biochemical test paper tube 100. Without external force damage, it is difficult to separate the cover 120 from the tube 110 and prevent the test sample in the biochemical test paper tube 100 from leaking.
  • the width of the cross section of the first counterbore 115 is equal to the width of the cross section of the limiting member 122.
  • the inner diameter of the first counterbore 115 is equal to the outer diameter of the limiting member 122.
  • the width of the cross section of the first counterbore 115 is greater than the width of the cross section of the second counterbore 116.
  • the inner diameter of the first counterbore 115 is larger than the inner diameter of the second counterbore 116.
  • first counterbore 115 is also provided with a notch for accommodating the connecting portion 130.
  • the top of the solution cavity 111 ie, the mouth of the cavity
  • the top of the test paper cavity 112 ie, the mouth of the cavity
  • the sealing film 114 is disposed in the second counterbore 116 to seal at least the solution chamber 111.
  • the cover 120 further includes a chamfering member 123, which is arranged on the outer wall of the limiting member 122 and integrated with the limiting member 122 forming.
  • the width of the cross section of the upper end of the chamfering member 123 is smaller than the width of the cross section of the lower end of the chamfering member 123.
  • the limiting member 122 communicates with the chamfering member 123 and is provided in the first counterbore 115, that is, the upper surface of the limiting member 122, the upper surface of the chamfering member 123, and the first counterbore 115
  • the upper surface of 115 is on the same horizontal plane.
  • the tube 110 further includes an opening member 117, which is provided on the upper surface or inside of the first counterbore 115 for Under certain circumstances, the lid 120 is separated from the pipe 110 by the lid opening member 117.
  • the cover opening part 117 is provided through the first counterbore 115. Specifically, the first end of the lid opening member 117 is located on the inner wall of the first counterbore 115, and the second end of the lid opening member 117 is located on the outer wall of the first counterbore 115, and the lid opening member 117 is passed through with the aid of an auxiliary tool, such as a pry Use a rod to lift the lid 120 to separate the lid 120 from the tube 110.
  • an auxiliary tool such as a pry Use a rod to lift the lid 120 to separate the lid 120 from the tube 110.
  • the lid opening member 117 is provided on the upper surface of the first counterbore 115. Specifically, the first end of the opening member 117 is located on the inner wall of the first counterbore 115, and the second end of the opening member 117 is located between the inner wall and the outer wall of the first counterbore 115, passing through the opening member with the aid of an auxiliary tool. 117, such as an opening pick, tilts the cover 120 to separate the cover 120 from the tube 110.
  • the usage method of this embodiment is basically the same as that of Embodiment 1, and will not be repeated here.
  • the cover part when the cover part closes the pipe part, it is difficult to separate the cover part from the pipe part under the action of the counterbore unit; the effect of the chamfering part that is difficult to provide a force point, even if the external force is strong
  • the counterbore unit and the chamfering part cannot separate the cover and the tube; in some cases, the cover can be separated from the tube by the opening part to recover the solution or substance in the biochemical test paper tube.
  • a biochemical test paper tube 100 includes a tube portion 110, a lid portion 120, and a connecting portion 130.
  • the tube portion 110 and the lid portion 120 are connected by the connecting portion 130. Closed.
  • connection relationship and structure of the connecting portion 130 are basically the same as those of the first embodiment, and will not be repeated here.
  • the tube portion 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113, a sealing film 114, and a counterbore unit.
  • the connection relationship and structure of the solution cavity 111, the test paper cavity 112, the sealing film 114, and the counterbore unit are the same as those of the second embodiment. It's basically the same, so I won't repeat it here.
  • the cover 120 includes a cavity 121, a limiting member 122, and a bursting member 124.
  • the connection relationship and structure of the cavity 121 and the limiting member 122 are basically the same as those in the first embodiment, and will not be repeated here.
  • the bursting component 124 is disposed inside the cover 120, its first end is connected to the inner bottom surface of the cover 120, and its second end is located at the opening of the cover 120. In the case where the cover 120 does not completely close the pipe 110, the second end of the bursting member 124 contacts the sealing film 114 to break the sealing film 114.
  • the second end of the bursting component 124 may be a blunt end, a pointed end, or a blade part. It can break the sealing film 114 when it contacts the sealing film 114.
  • the bursting member 124 is a blade portion, there are at least two blade portions for cutting the sealing film 114.
  • the method of use in this embodiment is as follows: first move the cover 120 to the tube 110 so that the bursting part 124 contacts and breaks the sealing film 114 to expose the solution cavity 111; put the sample to be tested, such as a throat swab, into the solution cavity 111; the cap 120 is closed to the tube 110, and the limiting component 121 of the cap 120 is immersed in the first counterbore 115; after the reaction in the solution chamber 111 is complete, the biochemical test paper tube 100 is tilted to make the reaction solution contact The immunochromatographic test paper in the test paper cavity 112, the reaction solution is chromatographed on the immunochromatographic test paper, and the test result can be obtained by observing the immunochromatographic test paper; after the test result is observed, the biochemical test paper tube 100 can be directly used as There is no need to worry about the leakage of the material in the biochemical test paper tube 100 in the treatment of medical waste.
  • a bursting component is provided on the cover to destroy the sealing film, reducing the probability of pollution caused by artificially destroying the sealing film, and improving the accuracy of the detection result.
  • a biochemical test paper tube 100 includes a tube portion 110, a lid portion 120, and a connecting portion 130.
  • the tube portion 110 and the lid portion 120 are connected by the connecting portion 130. Closed.
  • connection relationship and structure of the connecting portion 130 are basically the same as those of the first embodiment, and will not be repeated here.
  • the tube portion 110 includes a solution cavity 111, a test paper cavity 112, a sealing platform 113, a sealing film 114, a counterbore unit and a first fitting part 118, wherein the solution cavity 111, the test paper cavity 112, the sealing film 114, and the connection of the counterbore unit
  • the relationship and structure are basically the same as those in Embodiment 2, and will not be repeated here.
  • the first fitting members 118 are provided on the inner wall of the top of the pipe portion 110, and the first fitting members 118 are arranged at intervals along the axial direction of the pipe portion 110.
  • the first fitting part 118 is arranged on the inner wall of the second counterbore 116, and the first fitting part 118 is arranged at intervals along the axial direction of the second counterbore 116.
  • the cover 120 includes a cavity 121, a limiting component 122, a bursting component 124, a sealing component 125, and a second fitting component 126, wherein the connection relationship and structure of the cavity 121, the limiting component 122, and the bursting component 124 are the same Embodiment 3 is basically the same and will not be repeated here.
  • the sealing member 125 and the second fitting member 126 are spaced apart in the axial direction of the cover 120.
  • the sealing member 125 is located on the lower side of the lid 120
  • the second fitting member 126 is located on the upper side of the sealing member 125.
  • the sealing member 125 seals the tube 110, and the second fitting member 126 is fitted and connected to the first fitting member 118 so that the lid 120 and the tube 110 are tightly connected. connect.
  • the sealing member 125 is an annular protrusion whose outer diameter is equal to the inner diameter of the second counterbore 116 of the tube portion 110.
  • the tightness of the connection between the cover part and the pipe part is further improved, and the resistance to separate the cover part and the pipe part is greatly improved, which is effective Prevent leakage of the solution in the biochemical test paper tube, avoid polluting the environment, and prevent endangering life and health.
  • This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, a water-absorbing pad 230, a bonding pad 240, and a guiding membrane 250, wherein the guiding membrane 250, the binding pad 240, and the chromatographic membrane
  • the film 220 and the water absorbing pad 230 are sequentially arranged on the substrate 210.
  • the length of the biochemical test paper 200 is greater than the height of the test paper cavity 112.
  • the difference between the length of the biochemical test paper 200 and the height of the test paper cavity 112 is 1 mm to 5 mm, and the preferable difference is 2 mm and 3 mm.
  • the sample solution receiving end of the biochemical test paper 200 extends into the cavity 122 of the lid 120.
  • the substrate 210 is made of plastic, such as self-adhesive plastic.
  • the guiding film 250 is disposed on the upper surface of the substrate 210, that is, the lower surface of the guiding film 250 and the upper surface of the substrate 210 are connected, such as by bonding.
  • the end of the guiding film 250 is in contact with the front end of the bonding pad 240, and the guiding film 250 transfers the solution to the bonding pad 240.
  • the upper surface of the end of the guiding film 250 is in contact with the lower surface of the front end of the bonding pad 240, or the lower surface of the end of the guiding film 250 is in contact with the upper surface of the front end of the bonding pad 240.
  • the guiding film 250 is made of cellulose film.
  • the thickness of the guiding film 250 is less than 0.15 mm.
  • the bonding pad 240 is disposed on the upper surface of the substrate 210, that is, the lower surface of the bonding pad 240 and the upper surface of the substrate 210 are connected, such as by bonding.
  • the end of the bonding pad 240 is in contact with the front end of the chromatography membrane 220, and the bonding pad 240 transfers the solution to the chromatography membrane 220.
  • the upper surface of the end of the bonding pad 240 is in contact with the lower surface of the front end of the chromatography membrane 220, or the lower surface of the end of the bonding pad 240 is in contact with the upper surface of the front end of the chromatography membrane 220.
  • the bonding pad 240 is a colloidal gold pad.
  • the bonding pad 240 is made of glass fiber, polyester film, cellulose filter paper, non-woven fabric and other materials.
  • the solution chromatography speed of the guiding membrane 250 is lower than the solution chromatography speed of the bonding pad 240.
  • the chromatographic membrane 220 is disposed at least on the upper surface of the substrate 210, that is, the lower surface of the chromatographic membrane 220 and the upper surface of the substrate 210 are connected, such as by bonding.
  • the end of the chromatographic membrane 220 is in contact with the end of the absorbent pad 230, and the chromatographic membrane 220 transfers the solution to the absorbent pad 230.
  • the chromatographic membrane 220 is further provided with a detection line 221 and a quality control line 222, which are sequentially arranged along the front end to the end of the chromatographic membrane 220.
  • the chromatography membrane 220 is made of nitrocellulose membrane.
  • the absorbent pad 230 is disposed at least on the bottom surface of the substrate 210, that is, the top surface of the absorbent pad 230 and the bottom surface of the substrate 210 are connected, such as by bonding.
  • the end of the absorbent pad 230 is in contact with the end of the chromatography membrane 220.
  • the absorbent pad 230 is absorbent paper.
  • the end of the chromatographic membrane 220 and the end of the absorbent pad 230 are in contact with the end of the substrate 210 and the solution is transferred.
  • the end of the chromatography membrane 220 exceeds the end of the substrate 210 by a certain distance
  • the end of the absorbent pad 230 exceeds the end of the substrate 210 by a certain distance
  • the end of the chromatography membrane 220 and the absorbent pad The end of 230 contacts and performs solution transfer, that is, the lower surface of the end of the chromatography membrane 220 and the upper surface of the end of the absorbent pad 230 contact and transfer the solution.
  • the chromatography membrane 220, the substrate 210, and the absorbent pad 230 form a sandwich structure.
  • the chromatography membrane 220 is also disposed on the lower surface of the substrate 210, that is, the end of the chromatography membrane 220 is bent downward at the end of the substrate 210. Specifically, the upper surface of the end of the chromatography membrane 220 is in contact with the upper surface of the end of the absorbent pad 230 and the solution is transferred, or the lower surface of the end of the chromatography membrane 220 is in contact with the lower surface of the end of the absorbent pad 230 and the solution is transferred. transfer.
  • the length of the chromatography membrane 220 located on the upper surface of the substrate 210 is greater than the length of the chromatography membrane 220 located on the lower surface of the substrate 210; or, the chromatography membrane 220 located on the upper surface of the substrate 210 The length of is equal to the length of the chromatography membrane 220 on the lower surface of the substrate 210; or, the length of the chromatography membrane 220 on the upper surface of the substrate 210 is less than the length of the chromatography membrane 220 on the lower surface of the substrate 210.
  • the length of the chromatography membrane 220 located on the upper surface of the substrate 210 is greater than the length of the chromatography membrane 220 located on the lower surface of the substrate 210
  • the absorbent pad 230 is also disposed on the upper surface of the substrate 210, that is, the end of the absorbent pad 230 is bent upward at the end of the substrate 210. Specifically, the upper surface of the end of the absorbent pad 230 is in contact with the upper surface of the end of the chromatography membrane 220 and the solution is transferred, or the lower surface of the end of the absorbent pad 230 is in contact with the lower surface of the end of the chromatography membrane 220 and the solution is transferred. transfer.
  • the length of the absorbent pad 230 on the upper surface of the substrate 210 is greater than the length of the absorbent pad 230 on the lower surface of the substrate 210; or, the length of the absorbent pad 230 on the upper surface of the substrate 210 is equal to The length of the absorbent pad 230 on the bottom surface of the substrate 210; or, the length of the absorbent pad 230 on the top surface of the substrate 210 is less than the length of the absorbent pad 230 on the bottom surface of the substrate 210.
  • the length of the absorbent pad 230 on the upper surface of the substrate 210 is smaller than the length of the absorbent pad 230 on the lower surface of the substrate 210.
  • a thin film is also provided at the end of the chromatography membrane 220 and the end of the absorbent pad 230.
  • the thin film covers the chromatographic membrane 220 and the absorbent pad 230 to keep the chromatographic membrane 220 and the absorbent pad 230 in contact.
  • the length of the biochemical test paper 200 is 2 cm to 4 cm, preferably 2.8 cm, 3.0 cm, 3.2 cm, 3.5 cm.
  • This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, an absorbent pad 230, a bonding pad 240, a guiding film 250, and a sample pad 260, wherein the sample pad 260, the guiding film 250, the bonding pad 240, the chromatographic membrane 220 and the absorbent pad 230 are arranged on the substrate 210.
  • connection relationship, structure and composition of the substrate 210, the chromatographic membrane 220, the water-absorbing pad 230 and the bonding pad 240 are basically the same as those in Embodiment 1, and will not be repeated here.
  • the sample pad 260 is disposed on the upper surface of the substrate 210, that is, the lower surface of the sample pad 260 and the upper surface of the substrate 210 are connected, such as by bonding.
  • the sample pad 260 is made of glass fiber, polyester film, cellulose filter paper, non-woven fabric and other materials.
  • the end of the sample pad 260 is in contact with the front end of the guiding film 250, and the sample pad 260 transfers the solution to the guiding film 250.
  • the upper surface of the end of the sample pad 260 is in contact with the lower surface of the front end of the guide film 250, or the lower surface of the end of the sample pad 260 is in contact with the upper surface of the front end of the guide film 250.
  • the front end of the sample pad 260 is in contact with the end of the guiding film 250, and the guiding film 250 transfers the solution to the sample pad 260.
  • the upper surface of the end of the guiding film 250 is in contact with the lower surface of the front end of the sample pad 260, or the lower surface of the end of the guiding film 250 is in contact with the upper surface of the front end of the sample pad 260.
  • the end of the sample pad 260 is in contact with the front end of the bonding pad 240, and the sample pad 260 transfers the solution to the bonding pad 240.
  • the upper surface of the end of the sample pad 260 is in contact with the lower surface of the front end of the bonding pad 240, or the lower surface of the end of the sample pad 260 is in contact with the upper surface of the front end of the bonding pad 240.
  • the immunochromatographic test paper includes two guiding films 250 respectively arranged on the front and back sides of the sample pad 260, that is, the end of the first guiding film 250 and the sample pad 260
  • the first guiding film 250 transfers the solution to the sample pad 260.
  • the upper surface of the end of the first guiding film 250 is in contact with the lower surface of the front end of the sample pad 260, or the lower surface of the end of the first guiding film 250 is in contact with the upper surface of the front end of the sample pad 260 .
  • the end of the sample pad 260 is in contact with the second guiding film 250, and the sample pad 260 transfers the solution to the second guiding film 250.
  • the upper surface of the end of the sample pad 260 is in contact with the lower surface of the front end of the second guiding film 250, or the lower surface of the end of the sample pad 260 is in contact with the upper surface of the front end of the second guiding film 250.
  • the guiding membrane 250 may be the first guiding membrane; when there are two guiding membranes 250, the guiding membrane 250 close to the chromatographic membrane 220 may be The first guiding membrane, and the guiding membrane 250 away from the chromatographic membrane 220 may be the second guiding membrane.
  • the solution chromatography speed of the sample pad 260 is greater than the solution chromatography speed of the guiding membrane 250.
  • the length of the biochemical test paper 200 is 2 cm to 4 cm, preferably 3.2 cm, 3.5 cm.
  • This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, a water-absorbing pad 230, a bonding pad 240, a guiding film 250, and a sample limit film 270, wherein the sample limit film 270, the guide film
  • the guiding film 250, the bonding pad 240, the chromatographic film 220 and the water absorption pad 230 are sequentially arranged on the substrate 210.
  • connection relationship, structure and composition of the substrate 210, the chromatographic membrane 220, the water-absorbing pad 230, the bonding pad 240 and the guiding membrane 250 are basically the same as those of Embodiment 5, and will not be repeated here.
  • the sample limiting film 270 is disposed on the upper surface of the substrate 210, that is, the lower surface of the sample limiting film 270 is connected to the upper surface of the substrate 210, such as by bonding.
  • the end of the sample limiting film 270 is in contact with the front end of the guiding film 250, and the sample limiting film 270 transfers the solution to the guiding film 250.
  • the upper surface of the end of the sample limiting film 270 is in contact with the lower surface of the leading end of the guiding film 250, or the lower surface of the end of the sample limiting film 270 is in contact with the upper surface of the leading end of the guiding film 250.
  • the absorption saturation volume of the sample limiting membrane 270 is 2-20 ⁇ l, which can absorb a small amount of sample.
  • the sample limit film 270 is made of glass fiber, polyester film, cellulose filter paper and other materials.
  • the length of the biochemical test paper 200 is 2 cm to 4 cm, preferably 3.3 cm, 3.5 cm, 3.7 cm.
  • This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, an absorbent pad 230, a bonding pad 240, a guiding membrane 250, a sample pad 260, and a sample limit film 270.
  • the sample limit The membrane 270, the guiding membrane 250, the sample pad 260, the bonding pad 240, the chromatographic membrane 220 and the water absorption pad 230 are arranged on the substrate 210.
  • connection relationship, structure and composition of the substrate 210, the chromatographic membrane 220, the absorbent pad 230, the bonding pad 240, the guiding membrane 250 and the sample pad 260 are the same as those of the second embodiment and the third embodiment of Example 6. It's basically the same, so I won't repeat it here.
  • the sample limiting film 270 is disposed on the upper surface of the substrate 210, that is, the lower surface of the sample limiting film 270 is connected to the upper surface of the substrate 210, such as by bonding.
  • the end of the sample limiting film 270 is in contact with the front end of the guiding film 250, and the sample limiting film 270 transfers the solution to the guiding film 250.
  • the upper surface of the end of the sample limiting film 270 is in contact with the lower surface of the leading end of the guiding film 250, or the lower surface of the end of the sample limiting film 270 is in contact with the upper surface of the leading end of the guiding film 250.
  • the absorption saturation volume of the sample limiting membrane 270 is 2-20 ⁇ l, which can absorb a small amount of sample.
  • the sample limit film 270 is made of glass fiber, polyester film, cellulose filter paper and other materials.
  • the length of the biochemical test paper 200 is 2 cm to 4 cm, preferably 3.6 cm or 3.8 cm.
  • This embodiment relates to biochemical test papers placed in the biochemical test paper tubes of Examples 1 to 4.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 200 includes a substrate 210, a chromatographic membrane 220, a water-absorbing pad 230, a bonding pad 240, a guiding film 250, and a transparent protective film 280, wherein the guiding film 250 and the bonding pad 240 , The chromatographic membrane 220 and the absorbent pad 230 are sequentially arranged on the substrate 210.
  • connection relationship, structure and composition of the substrate 210, the chromatographic membrane 220, the water-absorbing pad 230, the bonding pad 240 and the guiding membrane 250 are basically the same as those of Embodiment 1, and will not be repeated here.
  • the lower surface of the transparent protective film 280 covers at least the bonding pad 240 and the chromatography film 220.
  • the use of the transparent protective film 280 can prevent the bonding pad 240 and the chromatography film 220 from contacting the exogenous aqueous mixture, and improve the accuracy of the detection result of the chromatography test paper.
  • the transparent protective film 280 can also be applied to the biochemical test papers of Examples 6-8.
  • the biochemical test paper 200 further includes a transparent hollow tube 300.
  • the transparent hollow tube 300 wraps the biochemical test paper 200 inside the transparent hollow tube 300, that is, the biochemical test paper 200 is disposed inside the transparent hollow tube 300.
  • the inner surface of the transparent hollow tube 300 is a hydrophobic surface.
  • the first end of the transparent hollow tube 300 is a closed end, and the second end is an open end.
  • the purpose of setting the open end is to facilitate the movement of the biochemical test paper 200 from the opening to the inside of the transparent hollow tube 300.
  • sample solution receiving end of the biochemical test paper 200 is located at the open end of the transparent hollow tube 300.
  • the transparent hollow tube 300 is made of a transparent material, such as plastic or thermoplastic resin, which is convenient for observing the detection or diagnosis result of the biochemical test paper 200.
  • the width of the cross section of the second end of the open end of the transparent hollow tube 300 is larger than the inner diameter of the cross section of the first end of the open end.
  • the width of the cross section of the open end of the transparent hollow tube 300 decreases from the second end of the open end to the first end of the open end.
  • putting the biochemical test paper 200 covered with a transparent hollow tube 300 into the test paper cavity 112 of the biochemical test paper tube 100 can prevent the biochemical test paper 200 from directly contacting the inner surface of the test paper cavity 112 and prevent the test paper cavity 112 from being damaged.
  • the surface tension of the inner surface affects the adsorption rate of the biochemical test paper 200.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Un tube de papier d'essai biochimique (100), comprenant une partie tube (110) et une partie couvercle (120). La partie tube (110) comprend une chambre de solution (111), la face d'extrémité supérieure de la chambre de solution (111) est pourvue d'une plate-forme d'étanchéité (113), la plate-forme d'étanchéité (113) est entièrement disposée autour de la chambre de solution (111), et lorsque la partie couvercle (120) ferme la partie de tube (110), la plateforme d'étanchéité (113) est à une certaine distance du fond de la partie de couvercle (120) ; et une chambre de papier d'essai (112) pour recevoir et placer un papier d'essai biochimique. Le tube de papier d'essai biochimique présente les avantages suivants : une solution de réaction est pré-placée dans la chambre de solution (111), et la chambre de solution (111) est fermée hermétiquement à l'aide d'un film d'étanchéité (114), et il n'y a pas besoin de personnel de détection pour préparer la solution et transférer la solution, réduisant ainsi les étapes d'opération ; et lors de l'utilisation, le film d'étanchéité (114) est détruite, et un échantillon à détecter est placé dans la chambre de solution (111), de telle sorte qu'une détection rapide peut être effectuée, ce qui permet d'améliorer l'efficacité de détection.
PCT/CN2021/101113 2020-06-19 2021-06-19 Tube de papier d'essai biochimique WO2021254514A1 (fr)

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