WO2021254512A1 - Structure de rupture de tube, tube à essai biochimique et tube opaque thermoconducteur - Google Patents

Structure de rupture de tube, tube à essai biochimique et tube opaque thermoconducteur Download PDF

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Publication number
WO2021254512A1
WO2021254512A1 PCT/CN2021/101111 CN2021101111W WO2021254512A1 WO 2021254512 A1 WO2021254512 A1 WO 2021254512A1 CN 2021101111 W CN2021101111 W CN 2021101111W WO 2021254512 A1 WO2021254512 A1 WO 2021254512A1
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WIPO (PCT)
Prior art keywords
tube
broken
broken pipe
biochemical test
pipe
Prior art date
Application number
PCT/CN2021/101111
Other languages
English (en)
Chinese (zh)
Inventor
许向华
戎振洋
喻晴
陈翔
周中人
Original Assignee
上海快灵生物科技有限公司
上海妙灵生物工程有限公司
上海金标生物科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN202120200347.6U external-priority patent/CN214278192U/zh
Priority claimed from CN202110097129.9A external-priority patent/CN112858658B/zh
Priority claimed from CN202110194027.9A external-priority patent/CN114958562A/zh
Application filed by 上海快灵生物科技有限公司, 上海妙灵生物工程有限公司, 上海金标生物科技有限公司 filed Critical 上海快灵生物科技有限公司
Publication of WO2021254512A1 publication Critical patent/WO2021254512A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
    • B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
    • B26F1/38—Cutting-out; Stamping-out
    • B26F1/44—Cutters therefor; Dies therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/24—Apparatus for enzymology or microbiology tube or bottle type
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Definitions

  • the invention relates to the technical field of biochemical detection devices, in particular to a broken tube structure, a biochemical test tube and a heat-conducting blind tube.
  • test tube When performing in vitro diagnosis or in vitro testing, in order to obtain qualitative results quickly, a combination of chromatography test paper and test tube is usually used as a rapid diagnostic tool or rapid detection tool. Generally speaking, the samples for diagnosis or testing usually have some dangers, such as certain toxicity and infectiousness. The used test tubes will be treated as medical waste.
  • test tube in the related art has some defects. For example, in the detection, the preparation of the reaction solution, sampling and other operations are required, which is time-consuming and labor-intensive. In addition, during testing, most of the samples to be tested are exposed, which is likely to endanger the health of the testing personnel. If a throat swab is used to collect samples for new coronavirus testing, the throat swab will be directly exposed to the air, or temporarily stored in a sealed container; when testing, the throat swab is taken out of the sealed container and placed in the testing device. Perform testing. In the process of removing the throat swab, the brief exposure of the throat swab increases the risk of infection of the inspector.
  • the purpose of the present invention is to provide a broken tube structure, a biochemical test tube, and a heat-conducting blind tube in view of the deficiencies in the prior art, so as to at least solve the problems of low detection efficiency and high infection risk in related technologies.
  • a broken pipe structure including:
  • At least two broken pipe parts are arranged above the body, and the broken pipe parts include:
  • a cutting element, the cutting element is arranged above the broken pipe component
  • the expansion element is arranged below the broken pipe part and connected with the cutting element;
  • the flow guiding part is arranged between two adjacent broken pipe parts.
  • the broken pipe component includes:
  • the first pipe breaking component, the first pipe breaking component includes:
  • a first cutting element, the first cutting element is arranged above the first pipe breaking component
  • a first expansion element, the first expansion element is arranged below the first pipe breaking component, located below the first cutting element, and connected to the first cutting element;
  • the second pipe breaking component, the second pipe breaking component includes:
  • a second cutting element, the second cutting element is arranged above the second pipe breaking component
  • a third cutting element, the third cutting element is arranged above the second pipe breaking component, located below the second cutting element, and connected to the second cutting element;
  • the second expansion element, the second expansion element is arranged under the second pipe breaking component, located under the third cutting element, and connected with the third cutting element.
  • it further includes:
  • the connecting part is arranged inside the main body and communicates with the outside of the main body.
  • the longitudinal section of the connecting member is convex.
  • it further includes:
  • the first fitting member is provided on the inner wall of the connecting member.
  • the first fitting component is a fitting protrusion and/or a fitting groove.
  • the number of the first pipe breaking component is equal to that of the second pipe breaking component.
  • the number of parts is equal or not equal.
  • the number of the first pipe breaking parts is equal to the number of the second pipe breaking parts, and the number of the first pipe breaking parts is equal to the number of the second pipe breaking parts.
  • a second pipe breaking part is arranged between two adjacent first pipe breaking parts, and a first breaking part is arranged between two adjacent second pipe breaking parts. Pipe parts.
  • the number of the first pipe-breaking component is one, the number of the second pipe-breaking component is two, and the flow guiding component is arranged on the first pipe-breaking component and the second pipe-breaking component. Between the pipes and between the two second broken pipe parts; or
  • first broken pipe parts There are two first broken pipe parts, one second broken pipe part, and the flow guiding part is arranged between the first broken pipe part and the second broken pipe part and the two Between the first broken pipe parts.
  • first pipe-breaking parts there are at least two first pipe-breaking parts, at least two second pipe-breaking parts, and the number of the first pipe-breaking parts is equal to that of the second pipe-breaking parts. Equal number
  • the second pipe breaking part is arranged between two adjacent first pipe breaking parts, and the first pipe breaking part is arranged between two adjacent second pipe breaking parts.
  • the first cutting element includes a first inclined side, and the first inclined side forms a first angle with a horizontal plane;
  • the second cutting element includes a second inclined side, and the second inclined side forms a second included angle with the horizontal plane;
  • the third cutting element includes a third inclined side, and the third inclined side forms a third angle with the horizontal plane;
  • first included angle and the second included angle are equal or unequal
  • first included angle and the third included angle are equal or unequal
  • second included angle is equal to or unequal to the third included angle.
  • the angles vary.
  • the second included angle is smaller than the third included angle.
  • the horizontal width of the first broken pipe component is equal to or different from the horizontal width of the second broken pipe component.
  • the horizontal width of the first broken pipe component is smaller than the horizontal width of the second broken pipe component.
  • the sum of the horizontal width of the first broken pipe component and the horizontal width of the second broken pipe component is less than or equal to the minimum horizontal width of the body.
  • the vertical height of the first pipe breaking component is equal to the vertical height of the second pipe breaking component.
  • the spreading element is a spreading inclined surface or a spreading spherical surface.
  • a biochemical test tube comprising the broken tube structure as described above, and the broken tube structure is arranged at the bottom of the solution chamber of the biochemical test tube.
  • it includes a tube portion and a cover portion
  • the tube includes:
  • a test paper fixing component where the top of the solution chamber communicates with the top of the test paper fixing component when the cover part closes the tube part;
  • a plurality of first positioning parts, the plurality of the first positioning parts are arranged at the bottom of the solution chamber for positioning the broken tube structure;
  • a plurality of second positioning components are provided on the upper part of the plurality of first positioning components.
  • a plurality of the first positioning components surrounds to form a first chamber
  • a plurality of the second positioning components surround to form a second cavity
  • the axis of the first chamber is coaxial with the axis of the second chamber.
  • a plurality of the first positioning components surrounds to form a first chamber
  • a plurality of the second positioning components surround to form a second cavity
  • the horizontal distance between the axis of the first chamber and the axis of the second chamber is less than 3 mm.
  • the biochemical test tube further includes:
  • a sample tube the sample tube is placed in the solution chamber, and is fixed in cooperation with a plurality of the second positioning components, and the bottom of the sample tube is in contact with the tip and/or the blade of the tube breaking structure.
  • the cover includes:
  • a pressing member, the pressing member is arranged inside the cover;
  • the pressing member is aligned with the solution chamber of the tube part.
  • the tube part further includes:
  • a sealing platform is arranged on the end surface of the top of the solution chamber, and the sealing platform is arranged all around the solution chamber;
  • the sealing platform When the cover part closes the tube part, the sealing platform has a certain distance from the bottom of the cover part.
  • the tube part further includes:
  • the sealing film is connected with the sealing platform to seal the solution cavity.
  • the biochemical test tube further includes:
  • Biochemical test paper the biochemical test paper is arranged inside the test paper fixing part;
  • the sample solution receiving end of the biochemical test paper is close to the cover part.
  • the length of the biochemical test paper is greater than the height of the test paper fixing part.
  • the biochemical test tube further includes:
  • a transparent hollow tube, the biochemical test paper is arranged inside the transparent hollow tube, and the transparent hollow tube is arranged inside the test paper fixing member.
  • one end of the transparent hollow tube is a closed end.
  • a thermally conductive blind tube which is applied to the biochemical test tube as described in the second aspect.
  • the thermally conductive blind tube is inserted into the biochemical test tube and is located at the bottom of the biochemical test tube. The broken pipe structure is destroyed.
  • they include:
  • a heat-conducting component is connected to the bottom opening of the blind tube body, and the heat-conducting component seals the bottom opening of the blind tube body;
  • the thermal conductivity of the thermally conductive component ⁇ >1.0 W/(m ⁇ K).
  • the material of the thermally conductive component includes metal.
  • the material of the thermally conductive component includes thermally conductive plastic, and the thermal conductivity of the thermally conductive plastic ⁇ >1.0 W/(m ⁇ K).
  • the heat-conducting component includes a heat-conducting block, and the heat-conducting block is fitted and connected with the blind pipe body.
  • a second fitting part is provided on the heat conducting block.
  • the second inserting component includes a convex ring provided on the heat conducting block and a groove provided on the blind tube body and matingly connected with the convex ring.
  • two convex rings are provided.
  • a blind tube cover is further included, and the blind tube cover and the blind tube body are integrally formed.
  • the present invention adopts the above technical solutions and has the following technical effects:
  • the broken tube structure, the biochemical test tube and the heat-conducting blind tube of the present invention use the broken tube structure to destroy the sample tube in a sealed state, so that the sample solution in the sample tube is mixed with the reaction solution, and subsequent operations and observations are performed , Making the whole detection process a fully enclosed detection, without any risk of exposure or infection; the broken tube structure includes multiple cutting elements and expansion elements, simplifying the steps of destroying the sample tube, and applying less pressure can destroy the sample tube , And make the solution in the sample tube flow out quickly through the guide part to improve the mixing efficiency.
  • Figure 1 is a schematic diagram (1) of the broken pipe structure according to the present application.
  • Figure 2 is a schematic diagram of the broken pipe structure according to the present application (2);
  • Figure 3 is a top view of the broken pipe structure according to the present application (1);
  • Figure 4 is a cross-sectional view (1) of the broken pipe structure according to the present application.
  • Figure 5 is a schematic diagram of the broken pipe structure according to the present application (3).
  • Figure 6 is a schematic diagram of the broken pipe structure according to the present application (4);
  • Figure 7 is a top view of the broken pipe structure according to the present application (2).
  • Figure 8 is a cross-sectional view of the broken pipe structure according to the present application (2).
  • Figure 9 is a schematic diagram of the broken pipe structure according to the present application (5).
  • Figure 10 is a schematic diagram of the broken pipe structure according to the present application (6);
  • Figure 11 is a top view of the broken pipe structure according to the present application (3).
  • Figure 12 is a cross-sectional view of the broken pipe structure according to the present application (3);
  • Figure 13 is a schematic diagram of the broken pipe structure according to the present application (7);
  • Figure 14 is a schematic diagram of the broken pipe structure according to the present application (8);
  • Figure 15 is a top view of the broken pipe structure according to the present application (4);
  • Figure 16 is a cross-sectional view of the broken pipe structure according to the present application (4);
  • Figure 17 is a schematic diagram of the broken pipe structure according to the present application (9).
  • Figure 18 is a bottom view of the broken pipe structure according to the present application.
  • Figure 19 is a cross-sectional view of the broken pipe structure according to the present application (5);
  • Figure 20 is a cross-sectional view of the broken pipe structure according to the present application (6);
  • Figure 21 is a cross-sectional view of the broken pipe structure according to the present application (7);
  • Figure 22 is a cross-sectional view (1) of the biochemical test tube according to the present application.
  • Figure 23 is a schematic diagram (1) of the use process of the biochemical test tube according to the present application.
  • Figure 24 is a schematic diagram (2) of the use process of the biochemical test tube according to the present application.
  • Figure 25 is a cross-sectional view of the biochemical test tube according to the present application (2).
  • Figure 26 is a cross-sectional view of the biochemical test tube according to the present application (3).
  • Figure 27 is a cross-sectional view of the biochemical test tube according to the present application (4);
  • Figure 28 is a cross-sectional view of the biochemical test tube according to the present application (5);
  • Figure 29 is a cross-sectional view of the biochemical test tube according to the present application (6);
  • Figure 30 is a cross-sectional view of the biochemical test tube according to the present application (7);
  • Figure 31 is a cross-sectional view (1) of the biochemical test tube in an unclosed state according to an embodiment of the present application
  • Figure 32 is a cross-sectional view of the closed state of the biochemical test tube according to an embodiment of the application (1);
  • Figures 33A-33B are cross-sectional views of the biochemical test tube in use according to an embodiment of the application (1);
  • Figure 34 is a cross-sectional view (2) of the biochemical test tube in an unclosed state according to an embodiment of the present application
  • 35A-35C are cross-sectional views (2) of the biochemical test tube in use according to an embodiment of the application;
  • Figure 36 is a cross-sectional view of the biochemical test tube in an unclosed state according to an embodiment of the application (3);
  • Figure 37 is a cross-sectional view of the closed state of the biochemical test tube according to an embodiment of the application (3);
  • Figures 38A-38C are cross-sectional views of the biochemical test tube in use according to the embodiment of the application (3);
  • Figure 39 is a cross-sectional view of the biochemical test tube in an unclosed state according to an embodiment of the application (4);
  • Figure 40 is a cross-sectional view of the closed state of the biochemical test tube according to an embodiment of the present application (4);
  • Figure 41 is a schematic diagram (1) of an immunochromatographic test paper according to an embodiment of the present application.
  • Figure 42 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (2);
  • Figure 43 is a schematic diagram of an immunochromatographic test paper according to an embodiment of the present application (2).
  • Figure 44 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (2);
  • Fig. 45 is a schematic diagram of an immunochromatographic test paper according to an embodiment of the present application (3);
  • Figure 46 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the application (3);
  • Figure 47 is a schematic diagram of an immunochromatographic test paper according to an embodiment of the present application (4);
  • Figure 48 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (4);
  • Figure 49 is a cross-sectional view of an immunochromatographic test paper according to an embodiment of the present application (5);
  • Figure 50 is a cross-sectional view of a transparent hollow tube according to an embodiment of the present application (1);
  • Figure 51 is a cross-sectional view of a transparent hollow tube according to an embodiment of the present application (2);
  • Figure 52 is a cross-sectional view of a biochemical test tube according to an embodiment of the present application (a biochemical test paper with a transparent hollow tube is provided);
  • FIG. 53 is a structural cross-sectional view of a blind heat conducting tube according to an embodiment of the present application.
  • Fig. 54 is a partial enlarged view of a blind heat conduction tube according to an embodiment of the present application.
  • Fig. 55 is a perspective view of the structure of a blind heat conduction tube according to an embodiment of the present application.
  • the reference signs are: 100, broken pipe structure; 110, body; 120, broken pipe part; 121, cutting element; 122, spreading element; 130, flow guiding part; 140, first broken pipe part; 141, The first cutting element; 142, the first spreading element; 150, the second broken tube part; 151, the second cutting element; 152, the third cutting element; 153, the second spreading element; 160, the connecting part; 170, The first fitting part;
  • Biochemical test tube 210, tube part; 211, solution chamber; 212, test paper fixing part; 213, first positioning part; 214, second positioning part; 215, sealing platform; 216, sealing film; 217, second insert Closing part; 220, cover part; 221, cavity; 222, pressing part; 223, sealing part; 224, third fitting part; 230, connecting part;
  • Biochemical test paper 401, basic layer; 402, chromatographic membrane; 403, test line; 404, quality control line; 405, absorbent pad; 406, binding pad; 407, guiding membrane; 408, sample pad; 409, sample Limited film; 410, transparent protective film;
  • a broken pipe structure 100 includes a main body 110, at least two broken pipe parts 120 and at least two flow guiding parts 130. Among them, at least two broken pipe parts 120 are arranged above the main body 110, and two adjacent broken pipe parts 120 are arranged with flow guiding parts 130.
  • the main body 110 is a cylinder or a truncated cone or a chamfered cylinder or a composite formed by superimposing multiple cylinders.
  • the broken pipe component 120 includes a cutting element 121 and a spreading element 122.
  • the cutting element 121 is arranged above the broken tube component 120 and used to cut the bottom of the sample tube;
  • the spreading element 122 is arranged below the cutting element 121 and is respectively connected to the main body 110 and the cutting element 121 for aligning
  • the cutting element 121 cuts the gap formed at the bottom of the sample tube to expand the gap.
  • the cutting element 121 includes an inclined side, the inclined side forms an angle with the horizontal plane, and the included angle is an acute angle.
  • the maximum horizontal width of the cutting element 121 is equal to the minimum horizontal width of the expansion element 122 and is smaller than the maximum horizontal width of the expansion element 122.
  • the vertical height of the cutting element 121 and the vertical height of the spreading element 122 are equal or different.
  • the horizontal width refers to the radial distance centered on a certain point on the horizontal plane, and does not refer to the thickness of related components
  • the vertical height refers to the axial distance centered on a certain point on the horizontal plane, and does not refer to the thickness of related components.
  • the cutting element 121 is a cutting edge.
  • the spreading element 122 is a spreading surface, and the spreading surface can be a spreading inclined surface or a spreading spherical surface.
  • the number of broken pipe parts 120 is at least two, and several broken pipe parts 120 are connected so that the respective cutting elements 121 and expansion elements 122 face outwards, and when viewed from a plan view, a petal-shaped structure is formed.
  • the flow guiding member 130 is arranged between two adjacent pipe breaking parts 120, and is used for the case where the breaking pipe part 120 is inserted into the bottom of the sample tube and destroys the sample tube, so that the sample solution in the sample tube flows along the guiding part 130 toward the sample tube. It flows out from the outside and mixes with the reaction solution or functional solution outside the sample tube for subsequent operations and observations.
  • the number of the guiding parts 130 is at least two, and not less than the number of the broken pipe parts 120.
  • the flow guide member 130 is a flow guide gap or a flow guide groove.
  • the broken tube structure 100 is made of a metal material that meets medical standards, such as 304 stainless steel.
  • the broken tube structure 100 may also be made of hard plastic material.
  • the method of use of the present invention is as follows: the broken tube structure 100 contacts the bottom of the sample tube (the bottom of the sample tube can be flat or curved); the cutting element 121 cuts the bottom of the sample tube so that the cutting element 121 enters the sample The inside of the tube; the expansion element 122 expands the gap formed by the cutting element 121 cutting the sample tube, that is, while the radial length of the gap becomes longer, the width of the gap becomes wider; at this time, under the action of the broken tube component 120 , The bottom of the sample tube is destroyed, and the sample solution in the sample tube flows out of the sample tube along the guide part 130, thereby mixing with the functional reaction solution outside the sample tube.
  • a broken pipe structure 100 includes a main body 110, a plurality of first broken pipe parts 140 and a plurality of flow guiding parts 130.
  • the first pipe breaking part 140 is arranged above the main body 110 and used to break the bottom of the sample tube; the flow guiding part 130 is arranged between two adjacent first pipe breaking parts 140.
  • the structure and connection relationship of the main body 110 and the flow guiding member 130 are basically the same as those of the first embodiment, and will not be repeated here.
  • the first pipe breaking component 140 includes a first cutting element 141 and a first spreading element 142.
  • the first cutting element 141 is arranged above the first broken tube component 140 and is used to cut the bottom of the sample tube;
  • the first spreading element 142 is arranged below the first cutting element 141, and is connected to the main body 110,
  • the first cutting element 141 is connected to expand the gap formed by the first cutting element 141 cutting the bottom of the sample tube to enlarge the gap.
  • the first cutting element 141 includes a first inclined side, the first inclined side and the horizontal plane form a first included angle, and the first included angle is an acute angle.
  • the maximum horizontal width of the first cutting element 141 is equal to the minimum horizontal width of the first expansion element 142 and is smaller than the maximum horizontal width of the first expansion element 142.
  • the vertical height of the first cutting element 141 is equal to or different from the vertical height of the first spreading element 142.
  • the first cutting element 141 is a cutting edge.
  • the first spreading element 142 is a spreading surface, and the spreading surface can be a spreading inclined surface or a spreading spherical surface.
  • the number of the first broken pipe parts 140 is at least two, and several first broken pipe parts 140 are connected so that the respective first cutting elements 141 and the first spreading elements 142 face outwards, when viewed from a top view, forming a petal-shaped structure .
  • the usage method of this embodiment is basically the same as that of Embodiment 1, and will not be repeated here.
  • a broken pipe structure 100 includes a main body 110, a plurality of second broken pipe parts 150, a plurality of flow guiding parts 130 and a connecting part 160.
  • the first broken pipe part 140 is arranged above the main body 110 for breaking the bottom of the sample tube;
  • the flow guiding part 130 is arranged between two adjacent first broken pipe parts 140;
  • the connecting part 160 is arranged inside the main body 110 , Used to fix the broken pipe structure 100 at a specific position of a specific device.
  • the structure and connection relationship of the main body 110 and the flow guiding member 130 are basically the same as those of the first embodiment, and will not be repeated here.
  • the second pipe breaking component 150 includes a second cutting element 151, a third cutting element 152 and a second spreading element 153.
  • the second cutting element 151 is arranged above the second pipe breaking part 150, and is used to cut the bottom of the sample tube for the first time;
  • the third cutting element 152 is arranged below the second cutting element 151 and is connected to the second cutting element 151 The element 151 is connected to cut the bottom of the sample tube for the second time;
  • the second spreading element 153 is arranged below the third cutting element 152 and is connected to the body 110 and the third cutting element 152, respectively, for cutting the third
  • the cutting element 152 cuts the gap formed at the bottom of the sample tube to expand the gap.
  • the second cutting element 151 includes a second inclined side, which forms a second included angle with the horizontal plane, and the second included angle is an acute angle.
  • the third cutting element 152 includes a third inclined side which forms a third included angle with the horizontal plane, and the third included angle is an acute angle.
  • the third included angle is greater than the second included angle.
  • the horizontal width of the second cutting element 151 is equal to the minimum horizontal width of the third cutting element 152 and is smaller than the maximum horizontal width of the third cutting element 152.
  • the vertical height of the second cutting element 151 is smaller than the vertical height of the third cutting element 152.
  • the maximum horizontal width of the third cutting element 152 is equal to the minimum horizontal width of the second expansion element 153 and is smaller than the maximum horizontal width of the second expansion element 153.
  • the vertical height of the third cutting element 152 is not less than the vertical height of the second spreading element 153.
  • the number of the second broken pipe components 150 is at least two, and several second broken pipe components 150 are connected so that the respective second cutting elements 151, third cutting elements 152 and second spreading elements 153 face outwards, as viewed from a top view , Forming a petal-shaped structure.
  • the connecting member 160 is disposed inside the main body 110 and communicates with the outside of the main body 110 to connect the connecting member 160 with the connecting element, so that the broken pipe structure 100 is fixed in a special position.
  • the usage method of this embodiment is basically the same as that of Embodiment 1, and will not be repeated here.
  • a broken pipe structure 100 includes a main body 110, a first broken pipe component 140, a second broken pipe component 150 and a flow guiding component 130.
  • the first broken pipe part 140 is arranged above the main body 110 and used to break the bottom of the sample tube;
  • the second broken pipe part 150 is arranged above the main body 110 and is connected to the first broken pipe part 140 for connecting with the first broken pipe part 140.
  • a broken pipe part 140 destroys the bottom of the sample tube together;
  • the flow guiding part 130 is arranged between the first broken pipe part 140 and the second broken pipe part 150.
  • the first pipe breaking component 140 includes a first cutting element 141 and a first spreading element 142.
  • the first cutting element 141 is arranged above the first pipe breaking component 140, and is used to cut the bottom of the sample tube for the first time;
  • the first expansion element 142 is arranged below the first cutting element 141, and is respectively connected with
  • the main body 110 and the first cutting element 141 are connected to expand the gap formed by the first cutting element 141 cutting the bottom of the sample tube to enlarge the gap.
  • the maximum horizontal width of the first cutting element 141 is equal to the minimum horizontal width of the first expansion element 142 and is smaller than the maximum horizontal width of the first expansion element 142.
  • the vertical height of the first cutting element 141 is smaller than the vertical height of the first spreading element 142.
  • the first cutting element 141 includes a first inclined side, the first inclined side and the horizontal plane form a first included angle, and the first included angle is an acute angle.
  • the second pipe breaking component 150 includes a second cutting element 151, a third cutting element 152 and a second spreading element 153.
  • the second pipe breaking part 150 is connected with the first pipe breaking part 140;
  • the second cutting element 151 is arranged above the second pipe breaking part 150, and is used to cut the bottom of the sample tube for the first time;
  • the third cutting element 152 is arranged under the second cutting element 151 and connected to the second cutting element 151, and is used to cut the bottom of the sample tube for the second time;
  • the second spreading element 153 is arranged under the third cutting element 152 and is connected with The main body 110 and the third cutting element 152 are connected to expand the gap formed by the third cutting element 152 cutting the bottom of the sample tube to enlarge the gap.
  • the second cutting element 151 is connected to the first cutting element 141, and the first spreading element 142 is connected to the third cutting element 152 and the second spreading element 153, respectively.
  • the second cutting element 151 includes a second inclined side, which forms a second included angle with the horizontal plane, and the second included angle is an acute angle.
  • the third cutting element 152 includes a third inclined side which forms a third included angle with the horizontal plane, and the third included angle is an acute angle.
  • the first included angle and the second included angle are equal or different, the first included angle and the third included angle are equal or different, and the second included angle is different from the third included angle.
  • the second included angle is smaller than the third included angle.
  • the horizontal width of the second cutting element 151 is equal to the minimum horizontal width of the third cutting element 152 and is smaller than the maximum horizontal width of the third cutting element 152.
  • the vertical height of the second cutting element 151 is smaller than the vertical height of the third cutting element 152.
  • the maximum horizontal width of the third cutting element 152 is equal to the minimum horizontal width of the second expansion element 153 and is smaller than the maximum horizontal width of the second expansion element 153.
  • the vertical height of the third cutting element 152 is not less than the vertical height of the second spreading element 153.
  • the vertical height of the first cutting element 141 is equal to the vertical height of the second cutting element 151, or the difference between the two is within the range of 0.5 ⁇ 0.1 mm.
  • the maximum horizontal width of the second expansion element 153 is greater than the maximum horizontal width of the first expansion element 142.
  • the sum of the vertical height of the third cutting element 152 and the vertical height of the second expansion element 153 is equal to the vertical height of the first expansion element 142, or the difference between the two is within the range of 0.5 ⁇ 0.1 mm.
  • the horizontal width refers to the radial distance centered on a certain point on the horizontal plane, and does not refer to the thickness of related components
  • the vertical height refers to the axial distance centered on a certain point on the horizontal plane, and does not refer to the thickness of related components.
  • A There are one first broken pipe part 140, and two second broken pipe parts 150.
  • the angle formed between the first broken pipe part 140 and the adjacent second broken pipe part 150 is 120°;
  • first broken pipe parts 140 and one second broken pipe part 150 There are two first broken pipe parts 140 and one second broken pipe part 150.
  • the angle formed between the first broken pipe parts 140 and the adjacent second broken pipe parts 150 is 120°;
  • the number of first broken pipe parts 140 is equal to the number of second broken pipe parts 150, and a first broken pipe part 140 is arranged between two adjacent second broken pipe parts 150, and two adjacent first broken pipe parts A second broken pipe part 150 is arranged between the pipe parts 140. If the number of the first broken pipe parts 140 and the number of the second broken pipe parts 150 are both n, the adjacent first broken pipe parts 140 and the second broken pipe parts The included angle formed between the pipe parts 150 is 360°/2n;
  • first broken pipe parts 140 and the number of second broken pipe parts 150 are not equal, then at least one second broken pipe part 150 is provided between two adjacent first broken pipe parts 140, and two adjacent first broken pipe parts At least one first pipe breaking part 140 is arranged between the two pipe breaking parts 150.
  • the adjacent first pipe breaking parts 140 The included angle formed with the second broken pipe part 150 is 360°/(m+n), or the included angle formed between two adjacent first broken pipe parts 140 is 360°/(m+n)( That is, the number of first broken pipe parts 140 is greater than the number of second broken pipe parts 150), or the angle formed between two adjacent second broken pipe parts 150 is 360°/(m+n) (that is, the second The number of broken pipe parts 150 is greater than the number of first broken pipe parts 140).
  • the flow guiding member 130 is provided between the first broken pipe part 140 and the second broken pipe part 150, and is used to insert the sample tube into the first broken pipe part 140 and the second broken pipe part 150.
  • the sample solution in the sample tube flows out of the sample tube along the guide member 130, and is mixed with the reaction solution or functional solution outside the sample tube for subsequent operations and observations.
  • the flow guiding member 130 is a flow guiding gap or a guiding channel or a guiding cavity.
  • the flow guiding part 130 is arranged between the first broken pipe part 140 and the second broken pipe part 150. And between the two second broken pipe parts 150.
  • the flow guiding part 130 is arranged between the first broken pipe part 140 and the second broken pipe part 150. Between the two first broken pipe parts 140.
  • the flow guiding part 130 is arranged between the first broken pipe part 140 and the second broken pipe part 150 Between the two first broken pipe parts 140, or between the two second broken pipe parts 150.
  • the method of use of the present invention is as follows: the broken tube structure 100 contacts the bottom of the sample tube (the bottom of the sample tube can be a flat bottom or an arc-shaped bottom); Cut so that the first cutting element 141 and the second cutting element 151 enter the inside of the sample tube; the third cutting element 152 continues to cut the sample tube along the gap formed by cutting the sample tube by the second cutting element 151, so that the gap is Enlarging, that is, the radial length of the gap becomes longer, but the width of the gap remains unchanged; while the third cutting element 152 cuts the bottom of the sample tube, the first spreading element 142 cuts the sample tube from the first cutting element 141.
  • the gap is expanded, that is, as the radial length of the gap becomes longer, the width of the gap becomes wider; the second expansion element 153 expands the gap formed by the third cutting element 152 cutting the sample tube, that is, the radial length of the gap As it becomes longer, the width of the gap becomes wider; at this time, under the combined action of the first broken tube component 140 and the second broken tube component 150, the bottom of the sample tube is destroyed, and the sample solution in the sample tube runs along the guide part 130 It flows out to the outside of the sample tube and mixes with the functional reaction solution outside the sample tube.
  • a broken pipe structure 100 includes a main body 110, a first broken pipe part 140, a second broken pipe part 150, and a flow guiding part 130 And the connecting part 160.
  • the first broken pipe part 140 is arranged above the main body 110 and used to break the bottom of the sample tube;
  • the second broken pipe part 150 is arranged above the main body 110 and is connected to the first broken pipe part 140 for connecting with the first broken pipe part 140.
  • a broken pipe part 140 destroys the bottom of the sample tube together; the flow guiding part 130 is arranged between the first broken pipe part 140 and the second broken pipe part 150; the connecting part 160 is arranged inside the main body 110 for connecting the broken pipe structure 100 is fixed at a specific location on a specific device.
  • the structure and embodiments of the main body 110, the first broken pipe part 140, the second broken pipe part 150, and the flow guiding part 130 are basically the same as those of the first embodiment, and will not be repeated here.
  • the connecting member 160 is disposed inside the main body 110 and communicates with the outside of the main body 110 to connect the connecting member 160 with the connecting element, so that the broken pipe structure 100 is fixed in a special position.
  • the advantage of this embodiment is that a connecting part is provided on the body, and the broken tube structure can be fixed at any special position, so as to adapt to test tubes of different specifications and meet different usage requirements.
  • a broken pipe structure 100 includes a main body 110, a first broken pipe part 140, a second broken pipe part 150, and a diversion The component 130, the connecting component 160, and the first fitting component 170.
  • the first broken pipe part 140 is arranged above the main body 110 and used to break the bottom of the sample tube;
  • the second broken pipe part 150 is arranged above the main body 110 and is connected to the first broken pipe part 140 for connecting with the first broken pipe part 140.
  • a broken pipe part 140 destroys the bottom of the sample tube together; the flow guiding part 130 is arranged between the first broken pipe part 140 and the second broken pipe part 150; the connecting part 160 is arranged inside the main body 110 for connecting the broken pipe structure 100 is fixed at a specific position of a specific device; the first fitting member 170 is arranged inside the connecting member 160 and is used for fitting the broken pipe structure 100 with a specific connecting element.
  • the structures and embodiments of the main body 110, the first broken pipe component 140, the second broken pipe component 150, the flow guiding component 130, and the connecting component 160 are basically the same as those of the first embodiment, and will not be repeated here.
  • the first fitting member 170 is an annular fitting groove.
  • the first fitting member 170 is an annular fitting protrusion.
  • the advantage of this embodiment is that the first fitting part is arranged inside the connecting part, which improves the connection strength between the broken pipe structure and any connecting element, and prevents the broken pipe structure from falling off during use.
  • a biochemical test tube 200 includes at least a tube portion. At least a solution cavity 211 is arranged inside, and the broken tube structure 100 is arranged at the bottom of the solution cavity 211.
  • the broken pipe structure 100 may be integrally formed with the pipe portion, or may be bonded to the pipe portion.
  • the method of use of this embodiment is as follows: as shown in Figures 23-24, insert the sample tube 300 into the solution chamber 211 of the biochemical test tube 200 so that the bottom of the sample tube 300 is in contact with the broken tube structure 100; 300 applies downward pressure to cause the broken tube structure 100 to destroy the bottom of the sample tube 300 (see Example 1 for the specific process); after the bottom of the sample tube 300 is broken, the sample solution in the sample tube 300 follows the broken tube structure 100
  • the flow guiding member 130 of ⁇ enters into the solution chamber 211 and mixes with the reaction solution in the solution chamber 211.
  • a biochemical test tube 200 includes at least a tube portion, and at least a solution chamber 211 is provided inside the tube portion. At least one first positioning component 213 is provided. The first positioning component 213 is used to limit the position of the broken pipe structure 100, and the broken pipe structure 100 and the first positioning component 213 are detachably connected.
  • the first positioning member 213 is connected to the inner wall and the bottom wall of the solution chamber 211.
  • first positioning component 213 there is one first positioning component 213.
  • the first positioning component 213 and the inner wall of the solution chamber 211 form a positioning cavity, and the broken tube structure 100 is detachably installed in the positioning cavity.
  • the first positioning member 213 and the inner wall of the solution chamber 211 form an inscribed circle, and the inner diameter of the inscribed circle is equal to the outer diameter of the body 110 of the broken tube structure 100, so that the broken tube structure 100 is fixed in the solution chamber. 211 at the bottom.
  • the plurality of first positioning components 213 form a positioning cavity, and the broken tube structure 100 is detachably installed in the positioning cavity.
  • the plurality of first positioning members 213 form an inscribed circle, the inner diameter of the inscribed circle is equal to the outer diameter of the body 110 of the broken tube structure 100, so that the broken tube structure 100 is fixed to the bottom of the solution chamber 211.
  • the advantage of this embodiment is that the specifications of the broken tube structure set in the biochemical test tube can be selected according to different usage requirements, so as to complete subsequent customized assembly, without additional production molds, and reduce production costs.
  • This embodiment is an illustrative embodiment of a biochemical test tube containing the broken tube structure of Embodiment 3 or Embodiment 5 or Embodiment 6, as shown in FIGS. 27-28, a biochemical test tube 200, which includes at least a tube portion. At least a solution cavity 211 is arranged inside the tube portion, and a first positioning component 213 is arranged at the bottom of the solution cavity 211, and the first positioning component 213 is used to limit the position of the broken tube structure 100.
  • the first positioning component 213 is connected to the bottom wall of the solution chamber 211.
  • the broken tube structure 100 is plug-connected with the first positioning component 213.
  • the first positioning component 213 is further provided with a fitting element for fitting connection with the first fitting component 170.
  • the advantage of this embodiment is that the broken pipe structure and the second positioning component are plug-connected to improve the connection strength and avoid displacement of the broken pipe structure during use.
  • a biochemical test tube 200 includes at least a tube portion, and at least a solution chamber 211 is provided inside the tube portion.
  • a number of first positioning components 213 are provided at the bottom of the 211, wherein the first positioning components 213 are used to limit the position of the broken pipe structure 100.
  • first positioning components 213 are connected to the inner wall and the bottom wall of the solution chamber 211, and one first positioning component 213 is connected to the bottom wall of the solution chamber 211.
  • a first positioning component 213 and the inner wall of the solution chamber 211 form a positioning cavity.
  • the first positioning component 213 is disposed at the position of the central axis of the positioning cavity, and the broken tube structure 100 is detachably installed in the positioning cavity.
  • the first positioning member 213 and the inner wall of the solution chamber 211 form an inscribed circle
  • the axis of the first positioning member 213 is coaxial with the axis of the inscribed circle
  • the inner diameter of the inscribed circle is the same as the body of the broken tube structure 100
  • the outer diameters of 110 are equal, so that the broken tube structure 100 is fixed to the bottom of the solution chamber 211.
  • the remaining first positioning components 213 form a positioning cavity.
  • the above-mentioned first positioning component 213 is disposed at the central axis of the positioning cavity, and the broken tube structure 100 is detachably installed in the positioning cavity.
  • a plurality of first positioning components 213 form an inscribed circle, the axis of the first positioning component 213 is coaxial with the axis of the inscribed circle, and the inner diameter of the inscribed circle is the same as the outer diameter of the body 110 of the broken pipe structure 100. The diameters are equal, so that the broken tube structure 100 is fixed to the bottom of the solution chamber 211.
  • the advantage of this embodiment is that the first positioning component is used to guide and limit the broken tube structure, and to strengthen the connection strength between the broken tube structure and the biochemical test tube.
  • a biochemical test tube 200 includes a tube part 210 and a cover part 220, and the cover part 220 is used to seal the tube part 210.
  • the tube 210 includes a solution chamber 211, a test paper fixing part 212, a number of first positioning parts 213, and a number of second positioning parts 214.
  • the axial direction of the solution chamber 211 is collinear or parallel to the axial direction of the pipe 210, and the solution chamber 211 is used to place a solution, such as a reaction solution.
  • the axial direction of the test paper fixing part 212 is parallel to the axial direction of the solution chamber 211, and the test paper fixing part 212 is used to place the biochemical test paper 400.
  • a number of first positioning components 213 are arranged at the bottom of the solution chamber 211 and surround to form a virtual first chamber for placing the broken tube structure 100.
  • the plurality of second positioning members 214 are arranged on the upper part of the plurality of first positioning members 213 and surround a virtual second chamber for guiding and restricting the position of the sample tube 300 placed in the solution chamber 211.
  • the virtual first chamber refers to a space formed by a plurality of first positioning components 213 with a virtual wall set to present a cavity with one side open.
  • the virtual second chamber refers to a space formed by a plurality of second positioning members 214 with a virtual wall to present a cavity with one side open.
  • the axis of the first chamber is coaxial or parallel to the axis of the second chamber, and is used to align the center (or center) of the bottom of the sample tube 300 with the broken tube structure 100, that is, the axis of the sample tube 300 and the broken tube
  • the axes of the structure 100 are approximately collinear so that the tube breaking structure 100 pierces the sample tube 300.
  • the horizontal distance between the axis of the first chamber and the axis of the second chamber is less than 3 mm.
  • the broken pipe structure 100 and the pipe portion 210 may be an integrated design or a separate design. In the case of a split design, the broken pipe structure 100 is installed in the first chamber, such as by bonding.
  • a number of first positioning components 213 are circumferentially arranged on the outer side of the broken pipe structure 100 with the broken pipe structure 100 as the center. Specifically, the included angle formed by two adjacent first positioning components 213 is 360°/n, where n is the number of first positioning components 213.
  • a number of second positioning members 214 are axially arranged outside the sample tube 300 with the sample tube 300 as the center.
  • the included angle formed by two adjacent second positioning components 214 is 360°/n, where n is the number of second positioning components 214.
  • the second positioning member 214 can block the first positioning member 213, that is, a second positioning member 214 is provided directly above each first positioning member 213; the second positioning member 214 may not
  • the first positioning member 213 is shielded, that is, a second positioning member 214 is arranged obliquely above each first positioning member 213, or, viewed from a top view, there is at least one first positioning member 214 between two adjacent second positioning members 214 Part 213.
  • the number of the first positioning components 213 and the number of the second positioning components 214 may be equal or different.
  • each second positioning member 214 contacting the sample tube 300 is matched with the outer surface of the sample tube 300. That is, the inner surfaces of the plurality of second positioning members 214 form a track, and the track has a guiding function and a limiting function. Under the action of the track, the sample tube 300 moves downward and is fixed in the virtual second chamber.
  • the cover 220 includes a cavity 221, and the cavity 221 is formed by the inner surface of the cover 220 bulging outward.
  • the longitudinal section of the cavity 221 is trapezoidal, circular arc or triangular.
  • the biochemical test tube 200 further includes a connecting portion 230, which is connected to the tube portion 210 and the cover portion 220, respectively.
  • the tube portion 210, the cover portion 220, and the connecting portion 230 may be integrally connected, that is, the biochemical test tube 200 is a one-piece test tube.
  • the connection part 230 may be a connection bar.
  • the tube portion 210, the cover portion 220, and the connecting portion 230 may be connected separately, that is, the biochemical test tube 200 is a split test tube.
  • the connecting part 230 may be a locking ring or a locking bar.
  • the tube part 210 and the cover part 220 are respectively provided with locking holes that cooperate with each other. When the cover part 220 closes the tube part 210, the locking bar sequentially passes through the locking holes of the tube part 210 and the cover part 220 to make The cover 220 and the pipe 210 are locked.
  • the method of use of this embodiment is as follows: as shown in Figures 33A to 33B, the sample to be tested is placed in the sample tube 300 and sealed; the solution cavity 211 is exposed, and the sample tube 300 is placed in the solution cavity 211; in several second positions Under the guiding and limiting effect of the component 214, the bottom of the sample tube 300 is aligned with the broken tube structure 100 provided at the bottom of the solution chamber 211, and is pierced by the broken tube structure 100; under the action of the flow channel 106, the solution chamber 211
  • the reaction solution is mixed with the sample to be tested in the sample tube 300 to obtain a mixed solution; the tube part 210 is sealed with the cap 220; after a certain time of reaction, the tube part 210 is tilted to make the immunochromatographic test paper set in the test paper fixing part 212
  • the sample solution receiving end of the sample solution contacts the mixed solution, and the mixed solution is chromatographed on the immunochromatographic test paper; the test result can be obtained by observing the immunochromatographic test paper
  • a biochemical test tube 200 includes a tube part 210, a cover part 220 and a connecting part 230.
  • the tube part 210 and the cover part 220 are connected by the connecting part 230, and the cover part 220 is used to seal the tube part 210.
  • connection relationship and structure of the cover 220 and the connection 230 are basically the same as those of the embodiment 11, and will not be repeated here.
  • the tube 210 includes a solution chamber 211, a test paper fixing part 212, a number of first positioning parts 213, a number of second positioning parts 214, a sealing platform 215, and a sealing film 216.
  • the solution chamber 211, the test paper fixing part 212, and a number of first positioning parts are basically the same as those of the embodiment 11, and will not be repeated here.
  • a sealing platform 215 is provided on the end surface of the top of the solution chamber 211, and the sealing platform 215 is arranged all around the solution chamber 211.
  • the width of the sealing platform 215 is at least 1 mm; the outer wall of the sealing platform 215 and the inner wall of the pipe 210 have a certain horizontal distance, and at least 0.5 mm; between the bottom wall of the sealing platform 215 and the inner wall of the pipe 210 Have a certain vertical distance, and at least 0.5mm.
  • the top of the sealing platform 215 does not contact the bottom of the pipe 210, that is, there is a certain vertical distance between the top of the sealing platform 215 and the bottom of the pipe 210, and it is at least 1 mm. .
  • the sealing film 216 is connected with the sealing platform 215 to seal the solution cavity 211 and is used to prevent the solution preset in the solution cavity 211 from overflowing.
  • the reaction solution when leaving the factory, the reaction solution can be preset in the solution chamber 211, and then the solution chamber 211 can be sealed with the sealing film 216; The reaction solution is placed inside the solution cavity 211, and finally the solution cavity 211 is sealed with a sealing film 216, and the biochemical test tube 200 is stored for later use.
  • the sealing film 216 can also seal the test paper fixing member 212.
  • the test paper fixing part 212 can be sealed before the biochemical test paper is placed on the test paper fixing part 212, that is, to prevent foreign matter from entering the test paper fixing part 212; the test paper fixing part 212 can also be sealed when the biochemical test paper is placed on the test paper fixing part 212, namely Keep the biochemical test paper free from external substances before it is used.
  • the sealing film 216 may be an aluminum foil film or a plastic packaging film.
  • the sealing film 216 can be assembled with the biochemical test tube 200 during the production process, can also be assembled with the biochemical test tube 200 before the transportation process, or can be assembled with the biochemical test tube 200 before the storage process.
  • the shape of the sealing film 216 is substantially the same as the shape of the cavity at the top of the solution chamber 211, that is, the cross-sectional area of the sealing film 216 is slightly larger than the cross-sectional area of the cavity at the top of the solution cavity 211.
  • an auxiliary tool to break the sealing film 216 such as a tool with a sharp point, a blunt end, and a blade.
  • the shape of the sealing film 216 is different from the shape of the cavity opening at the top of the solution chamber 211, that is, the sealing film 216 includes a sealing part and an extension part.
  • the sealing part seals the solution chamber 211. Part of it is formed in one piece.
  • the shape of the sealing part is basically the same as the shape of the cavity opening at the top of the solution chamber 211.
  • the extension part is in a strip shape and is used to separate the sealing part from the solution chamber 211.
  • the method of use of this embodiment is as follows: as shown in FIGS. 35A to 35C, the sealing film 216 is destroyed or removed, and the sample tube 300 loaded with the sample to be tested is placed into the solution chamber 211, and is guided by a number of second positioning members 214 Under the restriction, the bottom of the sample tube 300 is aligned with the broken tube structure 100 arranged at the bottom of the solution chamber 211, and is pierced by the broken tube structure 100; under the action of the flow channel 106, the reaction solution and the sample in the solution chamber 211
  • the sample to be tested in the tube 300 is mixed to obtain a mixed solution; the tube part 210 is sealed with the cap 220; after a certain time of reaction, the tube part 210 is tilted to receive the sample solution of the immunochromatographic test paper set in the test paper fixing part 212
  • a biochemical test tube 200 includes a tube part 210, a cover part 220, and a connecting part 230.
  • the tube part 210 and the cover part 220 are connected by the connecting part 230. Closed.
  • connection relationship and structure of the connecting portion 230 are basically the same as those of the embodiment 11, and will not be repeated here.
  • the tube 210 includes a solution chamber 211, a test paper fixing part 212, a number of first positioning parts 213, a number of second positioning parts 214, a sealing platform 215, and a sealing film 216.
  • the solution chamber 211, the test paper fixing part 212, and a number of first positioning parts The connection relationship and structure of the component 213, the plurality of second positioning components 214, the sealing platform 215, and the sealing film 216 are basically the same as those of the embodiment 12, and will not be repeated here.
  • the cover 220 includes a cavity 221 and a pressing member 222, wherein the connection relationship and structure of the cavity 221 are basically the same as those of the embodiment 11, and will not be repeated here.
  • the pressing member 222 is provided inside the cavity 221.
  • the pressing member 222 is a strip, which is used to align the pressing member 222 with the top of the sample tube 300 when the lid 220 closes the tube 210, and apply a basic element at the position where the pressing member 222 is in contact with the sample tube 300.
  • the vertical downward pressure causes the sample tube 300 to be quickly pierced by the broken tube structure 100.
  • the pressure intensity per unit area can be increased under the same pressure, and the speed at which the sample tube 300 is pierced by the broken tube structure 100 can be increased.
  • the method of use of this embodiment is as follows: as shown in FIGS. 38A to 38C, destroy or remove the sealing film 216, and place the sample tube 300 loaded with the sample to be tested into the solution chamber 211; use the cap 220 to close the tube 210, Under the guiding and limiting action of several second positioning parts 214, the bottom of the sample tube 300 is aligned with the broken tube structure 100 arranged at the bottom of the solution chamber 211; under the pressing of the pressing part 222, the bottom of the sample tube 300 is broken.
  • the structure 100 is punctured; under the action of the flow channel 106, the reaction solution in the solution chamber 211 is mixed with the sample to be tested in the sample tube 300 to obtain a mixed solution; the tube portion 210 is closed with the cap 220; after a certain period of reaction time, Tilt the tube portion 210 to make the sample solution receiving end of the immunochromatographic test paper arranged in the test paper fixing part 212 contact the mixed solution, and the mixed liquid is chromatographed on the immunochromatographic test paper; the detection can be obtained by observing the immunochromatographic test paper Result: After observing the test result, the biochemical test tube 200 can be directly treated as medical waste without worrying about the leakage of the material in the biochemical test tube 200.
  • a biochemical test tube 200 includes a tube part 210, a cover part 220, and a connecting part 230.
  • the tube part 210 and the cover part 220 are connected by the connecting part 230. Closed.
  • connection relationship and structure of the connecting portion 230 are basically the same as those of the embodiment 11, and will not be repeated here.
  • the tube portion 210 includes a solution chamber 211, a test paper fixing part 212, a number of first positioning parts 213, a number of second positioning parts 214, a sealing film 216 and a second fitting part 217.
  • the solution chamber 211, the test paper fixing part 212, a number of The connection relationship and structure of the first positioning component 213, the plurality of second positioning components 214, and the sealing film 216 are basically the same as those of the embodiment 12, and will not be repeated here.
  • the second fitting parts 217 are arranged on the inner wall of the top of the pipe 210 and are arranged at intervals along the axial direction of the pipe 210.
  • the cover 220 includes a cavity 221, a pressing member 222, a sealing member 223 and a third fitting member 224.
  • the connection relationship and structure of the cavity 221 and the pressing member 222 are basically the same as those in the third embodiment, and will not be repeated here.
  • the sealing member 223 and the third fitting member 224 are spaced apart in the axial direction of the cover 220.
  • the sealing member 223 is located on the lower side of the lid 220
  • the third fitting member 224 is located on the upper side of the sealing member 223.
  • the sealing member 223 seals the tube 210, and the second fitting member 217 is fitted and connected to the third fitting member 224, so that the lid 220 and the tube 210 are tightly connected. Connect to improve the anti-opening performance of the biochemical test tube 200.
  • the sealing member 223 is an annular protrusion whose outer diameter is equal to the inner diameter of the top of the tube 210.
  • the second fitting part 217 is an annular protrusion whose outer diameter is larger than the inner diameter of the top of the tube 210; the third fitting part 224 is an annular groove, which is connected to the second fitting part. 217 works closely together.
  • the sealing component, the second fitting component and the third fitting component of this embodiment the tightness of the connection between the cover part and the pipe part is further improved, and the resistance to separate the cover part and the pipe part is greatly improved, which is effective Prevent leakage of the solution in the biochemical test tube 200, avoid pollution of the environment, and prevent endangering life and health.
  • This embodiment relates to biochemical test papers placed in the biochemical test tubes of Examples 11-14.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 400 includes a base layer 401, a chromatographic membrane 402, an absorbent pad 405, a binding pad 406, and a guiding membrane 407, wherein the guiding membrane 407, the binding pad 406, and the chromatographic membrane 402 and the absorbent pad 405 are arranged on the base layer 401 in sequence.
  • the length of the biochemical test paper 400 is greater than the height of the test paper fixing part 212.
  • the difference between the length of the biochemical test paper 400 and the height of the test paper fixing member 212 is 1 mm to 5 mm, and the preferable difference is 2 mm and 3 mm.
  • the sample solution receiving end of the biochemical test paper 400 extends into the cavity 221 of the lid 220.
  • the base layer 401 is made of plastic, such as self-adhesive plastic.
  • the guiding film 407 is disposed on the upper surface of the base layer 401, that is, the lower surface of the guiding film 407 and the upper surface of the base layer 401 are connected, such as by bonding.
  • the end of the guiding film 407 is in contact with the front end of the bonding pad 406, and the guiding film 407 transfers the solution to the bonding pad 406.
  • the upper surface of the end of the guiding film 407 is in contact with the lower surface of the front end of the bonding pad 406, or the lower surface of the end of the guiding film 407 is in contact with the upper surface of the front end of the bonding pad 406.
  • the guiding film 407 is made of cellulose film.
  • the thickness of the guiding film 407 is less than 0.15 mm.
  • the bonding pad 406 is disposed on the upper surface of the base layer 401, that is, the lower surface of the bonding pad 406 and the upper surface of the base layer 401 are connected, such as by bonding.
  • the end of the bonding pad 406 is in contact with the front end of the chromatography membrane 402, and the bonding pad 406 transfers the solution to the chromatography membrane 402.
  • the upper surface of the end of the bonding pad 406 is in contact with the lower surface of the front end of the chromatography membrane 402, or the lower surface of the end of the bonding pad 406 is in contact with the upper surface of the front end of the chromatography membrane 402.
  • the bonding pad 406 is a colloidal gold pad.
  • the bonding pad 406 is made of glass fiber, polyester film, cellulose filter paper, non-woven fabric and other materials.
  • the solution chromatography speed of the guiding membrane 407 is lower than the solution chromatography speed of the binding pad 406.
  • the chromatographic membrane 402 is arranged at least on the upper surface of the base layer 401, that is, the lower surface of the chromatographic membrane 402 and the upper surface of the base layer 401 are connected, such as by bonding.
  • the end of the chromatographic membrane 402 is in contact with the end of the absorbent pad 405, and the chromatographic membrane 402 transfers the solution to the absorbent pad 405.
  • the chromatographic membrane 402 is further provided with a detection line 403 and a quality control line 404, which are sequentially arranged along the front end to the end of the chromatographic membrane 402.
  • the chromatographic membrane 402 is made of nitrocellulose membrane.
  • the absorbent pad 405 is at least disposed on the lower surface of the base layer 401, that is, the upper surface of the absorbent pad 405 and the lower surface of the base layer 401 are connected, such as by bonding.
  • the end of the absorbent pad 405 is in contact with the end of the chromatography membrane 402.
  • the absorbent pad 405 is absorbent paper.
  • the end of the chromatographic membrane 402 and the end of the absorbent pad 405 are in contact with the end of the base layer 401 and the solution is transferred.
  • the end of the chromatography membrane 402 exceeds the end of the base layer 401 by a certain distance
  • the end of the absorbent pad 405 exceeds the end of the base layer 401 by a certain distance
  • the end of the chromatography membrane 402 and the end of the absorbent pad 405 The ends contact and transfer the solution, that is, the lower surface of the end of the chromatography membrane 402 and the upper surface of the end of the absorbent pad 405 contact and transfer the solution.
  • the chromatographic membrane 402, the base layer 401 and the absorbent pad 405 form a sandwich structure.
  • the chromatography membrane 402 is also disposed on the lower surface of the base layer 401, that is, the end of the chromatography membrane 402 is bent downward at the end of the base layer 401. Specifically, the upper surface of the end of the chromatography membrane 402 is in contact with the upper surface of the end of the absorbent pad 405 and the solution is transferred, or the lower surface of the end of the chromatography membrane 402 and the lower surface of the end of the absorbent pad 405 are in contact and solution transfer.
  • the length of the chromatography membrane 402 located on the upper surface of the base layer 401 is greater than the length of the chromatography membrane 402 located on the lower surface of the base layer 401; or, the length of the chromatography membrane 402 located on the upper surface of the base layer 401 is equal to The length of the chromatography membrane 402 located on the lower surface of the base layer 401; or, the length of the chromatography membrane 402 located on the upper surface of the base layer 401 is less than the length of the chromatography membrane 402 located on the lower surface of the base layer 401.
  • the length of the chromatography membrane 402 located on the upper surface of the base layer 401 is greater than the length of the chromatography membrane 402 located on the lower surface of the base layer 401
  • the absorbent pad 405 is also disposed on the upper surface of the base layer 401, that is, the end of the absorbent pad 405 is bent upward at the end of the base layer 401. Specifically, the upper surface of the end of the absorbent pad 405 is in contact with the upper surface of the end of the chromatography membrane 402 and the solution is transferred, or the lower surface of the end of the absorbent pad 405 and the lower surface of the end of the chromatography membrane 402 are in contact and solution transfer.
  • the length of the absorbent pad 405 located on the upper surface of the base layer 401 is greater than the length of the absorbent pad 405 located on the lower surface of the base layer 401; or, the length of the absorbent pad 405 located on the upper surface of the base layer 401 is equal to the length of the absorbent pad 405 located on the upper surface of the base layer 401 Or, the length of the absorbent pad 405 on the upper surface of the base layer 401 is less than the length of the absorbent pad 405 on the lower surface of the base layer 401.
  • the length of the absorbent pad 405 located on the upper surface of the base layer 401 is smaller than the length of the absorbent pad 405 located on the lower surface of the base layer 401.
  • a thin film is also provided at the end of the chromatography membrane 402 and the end of the absorbent pad 405.
  • the thin film covers the chromatographic membrane 402 and the absorbent pad 405 so that the chromatographic membrane 402 and the absorbent pad 405 are kept in contact.
  • the length of the biochemical test paper 400 is 2 cm to 4 cm, preferably 2.8 cm, 3.0 cm, 3.2 cm, or 3.5 cm.
  • the usage method of this embodiment is as follows: put the biochemical test paper 400 into the test paper fixing part 212 of the biochemical test tube 200, and set the sample solution receiving end of the biochemical test paper 400 upward (ie the guiding film 407); destroy or remove the sealing film 216.
  • the bottom of the sample tube 300 is aligned with the broken tube structure provided at the bottom of the solution chamber 211 100, and punctured by the broken tube structure 100; under the action of the flow channel 106, the reaction solution in the solution chamber 211 is mixed with the sample to be tested in the sample tube 300 to obtain a mixed solution; the tube 210 is closed with the cap 220; After reacting for a certain period of time, tilt the tube 210 to make the guiding film 407 of the biochemical test paper 400 arranged in the test paper fixing part 212 contact the mixed liquid, and the mixed liquid undergoes chromatographic action on the biochemical test paper 400; by observing the biochemical test paper 400, The test results can be obtained; after observing the test results, the biochemical test tube 200 can be directly treated as medical waste, and there is no need to worry about the leakage of the material in the biochemical test tube 200.
  • This embodiment relates to biochemical test papers placed in the biochemical test tubes of Examples 11-14.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 400 includes a base layer 401, a chromatographic membrane 402, an absorbent pad 405, a binding pad 406, a guiding film 407, and a sample pad 408, wherein the sample pad 408 and the guiding film 407 ,
  • the bonding pad 406, the chromatographic membrane 402 and the water absorption pad 405 are arranged on the base layer 401.
  • connection relationship, structure and composition of the base layer 401, the chromatographic membrane 402, the water-absorbing pad 405 and the bonding pad 406 are basically the same as those in Embodiment 15, and will not be repeated here.
  • the sample pad 408 is disposed on the upper surface of the base layer 401, that is, the lower surface of the sample pad 408 and the upper surface of the base layer 401 are connected, such as by bonding.
  • the sample pad 408 is made of glass fiber, polyester film, cellulose filter paper, non-woven fabric and other materials.
  • the end of the sample pad 408 is in contact with the front end of the guiding film 407, and the sample pad 408 transfers the solution to the guiding film 407.
  • the upper surface of the end of the sample pad 408 is in contact with the lower surface of the front end of the guiding film 407, or the lower surface of the end of the sample pad 408 is in contact with the upper surface of the front end of the guiding film 407.
  • the front end of the sample pad 408 is in contact with the end of the guiding film 407, and the guiding film 407 transfers the solution to the sample pad 408.
  • the upper surface of the end of the guiding film 407 is in contact with the lower surface of the front end of the sample pad 408, or the lower surface of the end of the guiding film 407 is in contact with the upper surface of the front end of the sample pad 408.
  • the end of the sample pad 408 is in contact with the front end of the bonding pad 406, and the sample pad 408 transfers the solution to the bonding pad 406.
  • the upper surface of the end of the sample pad 408 is in contact with the lower surface of the front end of the bonding pad 406, or the lower surface of the end of the sample pad 408 is in contact with the upper surface of the front end of the bonding pad 406.
  • the immunochromatographic test paper includes two guiding films 407 respectively arranged on the front and back sides of the sample pad 408, that is, the first guiding film 407
  • the end of the membrane 407 is in contact with the front end of the sample pad 408, and the first guiding membrane 407 transfers the solution to the sample pad 408.
  • the upper surface of the end of the first guiding film 407 is in contact with the lower surface of the front end of the sample pad 408, or the lower surface of the end of the first guiding film 407 is in contact with the upper surface of the front end of the sample pad 408 .
  • the end of the sample pad 408 is in contact with the second guiding film 407, and the sample pad 408 transfers the solution to the second guiding film 407.
  • the upper surface of the end of the sample pad 408 is in contact with the lower surface of the front end of the second guiding film 407, or the lower surface of the end of the sample pad 408 is in contact with the upper surface of the front end of the second guiding film 407.
  • the guiding film 407 when there is only one guiding film 407, the guiding film 407 may be the first guiding film; when there are two guiding films 407, the guiding film 407 close to the chromatographic membrane 402 may be The first guiding membrane, and the guiding membrane 407 away from the chromatographic membrane 402 may be the second guiding membrane.
  • the solution chromatography speed of the sample pad 408 is greater than the solution chromatography speed of the guiding membrane 407.
  • the length of the biochemical test paper 400 is 2 cm to 4 cm, preferably 3.2 cm, 3.5 cm.
  • This embodiment relates to biochemical test papers placed in the biochemical test tubes of Examples 11-14.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 400 includes a base layer 401, a chromatographic membrane 402, an absorbent pad 405, a binding pad 406, a guiding film 407, and a sample limiting film 409.
  • the sample limiting film 409, the guiding film The membrane 407, the bonding pad 406, the chromatographic membrane 402 and the water absorption pad 405 are arranged on the base layer 401 in sequence.
  • connection relationship, structure and composition of the base layer 401, the chromatographic membrane 402, the water-absorbing pad 405, the bonding pad 406 and the guiding membrane 407 are basically the same as those of Embodiment 16, and will not be repeated here.
  • the sample limiting film 409 is disposed on the upper surface of the base layer 401, that is, the lower surface of the sample limiting film 409 is connected to the upper surface of the base layer 401, such as by bonding.
  • the end of the sample limiting film 409 is in contact with the front end of the guiding film 407, and the sample limiting film 409 transfers the solution to the guiding film 407.
  • the upper surface of the end of the sample limiting film 409 is in contact with the lower surface of the leading end of the guiding film 407, or the lower surface of the end of the sample limiting film 409 is in contact with the upper surface of the leading end of the guiding film 407.
  • the liquid absorption saturation volume of the sample limiting membrane 409 is 2-20 ⁇ l, which can absorb a small amount of samples.
  • the sample limit film 409 is made of glass fiber, polyester film, cellulose filter paper and other materials.
  • the length of the biochemical test paper 400 is 2 cm to 4 cm, preferably 3.3 cm, 3.5 cm, 3.7 cm.
  • This embodiment relates to biochemical test papers placed in the biochemical test tubes of Examples 11-14.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 400 includes a base layer 401, a chromatographic membrane 402, an absorbent pad 405, a binding pad 406, a guiding membrane 407, a sample pad 408, and a sample limit film 409, wherein the sample limit film 409, the guiding membrane 407, the sample pad 408, the binding pad 406, the chromatography membrane 402, and the water absorption pad 405 are arranged on the base layer 401.
  • connection relationship, structure and composition of the base layer 401, the chromatographic membrane 402, the absorbent pad 405, the bonding pad 406, the guiding membrane 407 and the sample pad 408 are basically the same as those of the second and third embodiments of Example 16. The same, so I won’t repeat them here.
  • the sample limiting film 409 is disposed on the upper surface of the base layer 401, that is, the lower surface of the sample limiting film 409 is connected to the upper surface of the base layer 401, such as by bonding.
  • the end of the sample limiting film 409 is in contact with the front end of the guiding film 407, and the sample limiting film 409 transfers the solution to the guiding film 407.
  • the upper surface of the end of the sample limiting film 409 is in contact with the lower surface of the leading end of the guiding film 407, or the lower surface of the end of the sample limiting film 409 is in contact with the upper surface of the leading end of the guiding film 407.
  • the liquid absorption saturation volume of the sample limiting membrane 409 is 2-20 ⁇ l, which can absorb a small amount of samples.
  • the sample limit film 409 is made of glass fiber, polyester film, cellulose filter paper and other materials.
  • the length of the biochemical test paper 400 is 2 cm to 4 cm, preferably 3.6 cm or 3.8 cm.
  • This embodiment relates to biochemical test papers placed in the biochemical test tubes of Examples 11-14.
  • the biochemical test paper is an immunochromatographic test paper as an example for description.
  • a biochemical test paper 400 includes a base layer 401, a chromatographic membrane 402, a water absorption pad 405, a bonding pad 406, a guiding film 407, and a transparent protective film 410, wherein the guiding film 407, the bonding pad 406, The chromatographic membrane 402 and the absorbent pad 405 are sequentially arranged on the base layer 401.
  • connection relationship, structure and composition of the base layer 401, the chromatographic membrane 402, the water-absorbing pad 405, the bonding pad 406 and the guiding membrane 407 are basically the same as those of Embodiment 15, and will not be repeated here.
  • the lower surface of the transparent protective film 410 covers at least the bonding pad 406 and the chromatographic film 402.
  • the use of the transparent protective film 410 can prevent the bonding pad 406 and the chromatography membrane 402 from contacting the exogenous aqueous mixture, and improve the accuracy of the detection result of the chromatography test paper.
  • the transparent protective film 410 can also be applied to the immunochromatographic test papers of Examples 16-18.
  • the biochemical test paper 400 further includes a transparent hollow tube 500.
  • the transparent hollow tube 500 wraps the biochemical test paper 400 inside the transparent hollow tube 500, that is, the biochemical test paper 400 is disposed inside the transparent hollow tube 500.
  • the inner surface of the transparent hollow tube 500 is a hydrophobic surface.
  • the first end of the transparent hollow tube 500 is a closed end, and the second end is an open end.
  • the purpose of setting the open end is to facilitate the movement of the biochemical test paper 400 from the opening to the inside of the transparent hollow tube 500.
  • sample solution receiving end of the biochemical test paper 400 is located at the open end of the transparent hollow tube 500.
  • the transparent hollow tube 500 is made of a transparent material, such as plastic or thermoplastic resin, which is convenient for observing the detection or diagnosis result of the biochemical test paper 400.
  • the width of the cross section of the second end of the open end of the transparent hollow tube 500 is larger than the inner diameter of the cross section of the first end of the open end.
  • the width of the cross section of the open end of the transparent hollow tube 500 decreases from the second end of the open end to the first end of the open end.
  • putting the biochemical test paper 400 covered with a transparent hollow tube 500 into the test paper fixing part 212 of the biochemical test tube 200 can prevent the biochemical test paper 400 from directly contacting the inner surface of the test paper fixing part 212 and prevent the test paper fixing part
  • the surface tension of the inner surface of 212 affects the adsorption rate of the biochemical test paper 400.
  • a thermally conductive blind tube 600 includes a blind tube body 610 and a thermally conductive component 620 arranged at the bottom of the blind tube body 610, wherein the blind tube body 610 has openings at both ends; the thermally conductive component 620 is connected to the blind tube body 610.
  • the bottom end of the tube body 610 is open, and the heat-conducting component 620 seals the bottom end of the blind tube body 610; the thermal conductivity of the heat-conducting component 620 is ⁇ >1.0 W/(m ⁇ K).
  • the material of the heat-conducting component 620 may be metal, and when the material of the heat-conducting component 620 is metal, the heat-conducting component 620 is fitted and connected with the blind tube body 610;
  • the material of the heat-conducting component 620 can be a heat-conducting plastic.
  • the material of the blind tube body 610 may be ordinary plastic.
  • the bottom of the blind tube body 610 is directly sealed with the heat conducting component 620, which not only improves the thermal conductivity, but also makes the structure of the blind tube 600 simple, which is convenient for manufacturing and saves costs.
  • the heat-conducting component 620 includes a heat-conducting block 621, and the heat-conducting block 621 is fitted and connected with the blind tube body 610.
  • a fourth fitting part is provided on the heat conducting block 621, where the fourth fitting part includes a convex ring 622 arranged on the heat conducting block 621 and a groove arranged on the blind tube body 610 to be matedly connected with the convex ring 622 611.
  • two convex rings 622 are provided, of which one convex ring 622 is connected to the groove 611, and the other convex ring 622 is attached to the inner wall of the blind tube body 610 to improve the sealing performance.
  • the thermally conductive blind tube 600 further includes a blind tube cover 630, and the blind tube cover 630 and the blind tube body 610 are integrally formed. Specifically, the top of the blind tube cover 630 has a figure-eight-shaped structure, so that the blind tube cover 630 has a certain guiding effect.
  • the thermally conductive blind tube 600 can be placed in the biochemical test tube 200 for convenience. Detection operation.
  • the heat-conducting blind tube 600 enters the inside of the biochemical test tube 200 under the action of several second positioning members 214 of the biochemical test tube 200, and contacts the broken tube structure 100 at the bottom of the biochemical test tube 200, and is broken by the tube structure. 100 destroyed.

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Abstract

L'invention concerne une structure (100) de rupture de tube, un tube à essai biochimique (200) et un tube opaque thermoconducteur (600). La structure (100) de rupture de tube comprend un corps principal (110), un composant (120) de rupture de tube et un composant de guidage d'écoulement (130). Le composant (120) de rupture de tube comprend un élément de coupe (121) et un élément d'étalement (122) agencés dans l'ordre de haut en bas. La structure (100) de rupture de tube peut être utilisée pour rompre un tube à échantillon (300) dans un état fermé, de sorte qu'une solution d'échantillon dans le tube à échantillon (300) soit mélangée à une solution de réaction, après quoi des opérations et des observations ultérieures peuvent être effectuées, ce qui permet d'assurer que tout le processus de test est complètement fermé sans risque quelconque d'exposition ni d'infection. La structure (100) de rupture de tube comprend de multiples éléments de coupe (121) et éléments d'étalement (122). L'invention simplifie les étapes de rupture d'un tube à échantillon (300), réduit la force de pression requise pour rompre le tube à échantillon (300) et permet à une solution dans le tube à échantillon (300) d'être rapidement évacuée au moyen d'un élément de guidage d'écoulement (130), ce qui permet d'améliorer l'efficacité de mélange.
PCT/CN2021/101111 2020-06-19 2021-06-19 Structure de rupture de tube, tube à essai biochimique et tube opaque thermoconducteur WO2021254512A1 (fr)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
CN202010569184 2020-06-19
CN202010569184.9 2020-06-19
CN202021152906.2 2020-06-19
CN202021152906 2020-06-19
CN202120200347.6U CN214278192U (zh) 2021-01-25 2021-01-25 一种破管结构及生化试管
CN202120200347.6 2021-01-25
CN202110097129.9 2021-01-25
CN202110097129.9A CN112858658B (zh) 2021-01-25 2021-01-25 一种破管结构及生化试管
CN202110194027.9A CN114958562A (zh) 2021-02-20 2021-02-20 一种导热盲管
CN202110194027.9 2021-02-20

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WO2021254512A1 true WO2021254512A1 (fr) 2021-12-23

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KR20100002115U (ko) * 2008-08-19 2010-03-02 정준채 신축배수구의 배수공 성형장치
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CN205574438U (zh) * 2016-03-14 2016-09-14 上海快灵生物科技有限公司 破管机构及包含有该破管机构的密封性试管组件
CN206476995U (zh) * 2016-06-13 2017-09-08 秦荣 一种pcr试管
CN108680573A (zh) * 2018-08-27 2018-10-19 陈继贵 序贯粪隐血采集检测一体装置
CN110305768A (zh) * 2018-03-27 2019-10-08 凸版印刷株式会社 开孔器、分注移液管架、核酸提取组件、开孔方法及核酸提取方法
CN112816681A (zh) * 2020-06-19 2021-05-18 上海快灵生物科技有限公司 一种生化试纸管
CN112858658A (zh) * 2021-01-25 2021-05-28 上海快灵生物科技有限公司 一种破管结构及生化试管
CN112916069A (zh) * 2021-01-25 2021-06-08 上海快灵生物科技有限公司 一种试管盖及试管

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100002115U (ko) * 2008-08-19 2010-03-02 정준채 신축배수구의 배수공 성형장치
CN102876569A (zh) * 2011-07-11 2013-01-16 瑞基海洋生物科技股份有限公司 用于热对流聚合酶连锁反应装置的毛细管
CN205574438U (zh) * 2016-03-14 2016-09-14 上海快灵生物科技有限公司 破管机构及包含有该破管机构的密封性试管组件
CN206476995U (zh) * 2016-06-13 2017-09-08 秦荣 一种pcr试管
CN110305768A (zh) * 2018-03-27 2019-10-08 凸版印刷株式会社 开孔器、分注移液管架、核酸提取组件、开孔方法及核酸提取方法
CN108680573A (zh) * 2018-08-27 2018-10-19 陈继贵 序贯粪隐血采集检测一体装置
CN112816681A (zh) * 2020-06-19 2021-05-18 上海快灵生物科技有限公司 一种生化试纸管
CN112858658A (zh) * 2021-01-25 2021-05-28 上海快灵生物科技有限公司 一种破管结构及生化试管
CN112916069A (zh) * 2021-01-25 2021-06-08 上海快灵生物科技有限公司 一种试管盖及试管

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