CN212722908U - Biochemical test paper and test tube - Google Patents
Biochemical test paper and test tube Download PDFInfo
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- CN212722908U CN212722908U CN202021152072.5U CN202021152072U CN212722908U CN 212722908 U CN212722908 U CN 212722908U CN 202021152072 U CN202021152072 U CN 202021152072U CN 212722908 U CN212722908 U CN 212722908U
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Abstract
The utility model relates to a biochemical test paper and a test tube, wherein the biochemical test paper comprises a test paper main body; the transparent hollow tube, transparent hollow tube formula hollow tube as an organic whole, the test paper strip main part sets up in the inside of transparent hollow tube, and the internal surface of transparent hollow tube is hydrophobic surface. The biochemical test strip has the advantages that the test strip main body is sleeved by the transparent hollow tube, the test strip main body is effectively isolated from the outside, the hydrophobic inner surface of the transparent hollow tube is utilized, the test strip main body is prevented from being directly contacted with the inner surface of a biochemical test tube, and the surface tension of the inner surface of the biochemical test tube is prevented from influencing the chromatography result of the test strip main body.
Description
Technical Field
The utility model relates to a short-term test technical field especially relates to a biochemical test paper and test tube.
Background
In vitro diagnosis or in vitro detection, biochemical test paper is usually used as a rapid diagnosis tool or a rapid detection tool in order to obtain qualitative results rapidly. The existing biochemical test paper is generally placed in a protective bag or a protective box in batches and is taken out from the protective bag or the protective box when in use.
The biochemical test paper has some defects, such as frequent taking can cause the state change in the protective bag or the protective box, the biochemical test paper book is easy to be polluted, the biochemical test paper cannot be used, the detection result is further influenced, and unnecessary loss is caused.
At present, no effective solution is provided for the problems that the biochemical test paper is polluted, cannot be used and has increased loss due to the fact that the biochemical test paper is susceptible to the external environment or exogenous substances in the related technology.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a biochemical test paper and test tube to the not enough among the prior art to solve biochemical test paper in the correlation technique at least and wet or contaminated unable problem that uses, the loss increases.
In order to achieve the purpose, the utility model adopts the technical proposal that:
the first aspect of the present invention is to provide a biochemical test paper, which includes:
a test strip body;
the test strip comprises a transparent hollow tube, wherein the transparent hollow tube is an integrated hollow tube, the test strip main body is arranged inside the transparent hollow tube, and the inner surface of the transparent hollow tube is a hydrophobic surface.
In one embodiment, the first end of the transparent hollow tube is closed.
In one embodiment thereof, the transparent hollow tube
The method comprises the following steps:
an open member, a first end of the open member being connected to a second end of the transparent hollow tube;
the width of the cross section of the second end of the opening part is larger than the width of the cross section of the first end of the opening part.
In one embodiment, the width of the cross section of the opening member decreases from the second end of the opening member to the first end of the opening member.
In one embodiment thereof, the transparent hollow tube further comprises:
a closure member disposed at the second end of the opening member.
In one embodiment, the closing component is any one of a snap patch, a zipper, an embossed bone and a locking ring.
In one embodiment, the test strip body comprises:
a substrate;
a chromatographic membrane disposed on an upper surface of the substrate;
the water absorption pad is arranged on the lower surface of the base material;
wherein the chromatographic membrane and the absorbent pad are contacted at the end of the substrate and solution transfer is performed.
In one embodiment thereof, the end of the chromatographic membrane is a distance beyond the end of the substrate;
the tail end of the absorbent pad exceeds the tail end of the base material by a certain distance;
the end of the chromatographic membrane is contacted with the end of the absorbent pad and solution transfer is carried out.
In one embodiment, the chromatographic membrane is also arranged on the lower surface of the substrate, and the tail end of the chromatographic membrane and the tail end of the water absorption pad are contacted on the lower surface of the substrate and perform solution transmission.
In one embodiment, the absorbent pad is further disposed on the upper surface of the substrate, and the ends of the chromatographic membrane and the absorbent pad are in contact with each other on the upper surface of the substrate and perform solution transfer.
In one embodiment, the biochemical test strip further comprises:
a conjugate pad disposed on the substrate, an end of the conjugate pad contacting a front end of the chromatographic membrane and delivering a solution to the chromatographic membrane;
a guide film disposed on the substrate, a distal end of the guide film contacting a front end of the conjugate pad and transferring a solution to the conjugate pad;
wherein the solution chromatography speed of the guide membrane is less than that of the binding pad.
In one embodiment, the guide film has a thickness of less than 0.15 mm.
In one embodiment, the biochemical test strip further comprises:
a sample pad disposed on the substrate, a distal end of the sample pad contacting a front end of the guide membrane and transferring a solution to the guide membrane.
In one embodiment, the biochemical test strip further comprises:
a sample pad disposed on the substrate, a distal end of the guide membrane contacting a front end of the sample pad and delivering a solution to the sample pad.
In one embodiment, the biochemical test strip further comprises:
a sample limiting membrane disposed on the substrate, a distal end of the sample limiting membrane contacting a front end of the guide membrane and transferring a solution to the guide membrane.
In one embodiment, the liquid absorption saturation volume of the sample limiting film is 2-20 μ l.
In one embodiment, the immunochromatographic test strip further comprises:
and the filter pad is arranged on the base material, and the tail end of the guide membrane is in contact with the front end of the filter pad and transmits the solution to the filter pad.
In one embodiment, the immunochromatographic test strip further comprises:
and the water retaining cushion is arranged close to the front end of the guide film.
In one embodiment, the biochemical test strip further comprises:
a transparent protective film covering at least the chromatographic carrier and the conjugate pad.
In one embodiment, the chromatographic membrane comprises a detection line and a quality control line which are arranged in sequence.
In one embodiment, the lower surface of the end of the absorbent pad is in contact with the upper surface of the end of the chromatographic membrane; or
The upper surface of the tail end of the water absorption pad is contacted with the lower surface of the tail end of the chromatographic membrane.
In one embodiment, the lower surface of the distal end of the conjugate pad is in contact with the upper surface of the leading end of the chromatographic membrane; or
The upper surface of the distal end of the conjugate pad is in contact with the lower surface of the leading end of the chromatographic carrier.
In one embodiment thereof, a lower surface of the end of the guide film is in contact with an upper surface of the front end of the bonding pad; or
An upper surface of a tip of the guide film is in contact with a lower surface of a front end of the bonding pad.
In one embodiment, a lower surface of a tip of the guide membrane is in contact with an upper surface of a front end of the filter pad; or
The upper surface of the end of the guide membrane is in contact with the lower surface of the front end of the filter pad.
In one embodiment, the lower surface of the distal end of the filter pad is in contact with the doping surface of the front end of the conjugate pad; or
The upper surface of the end of the filter pad is in contact with the lower surface of the front end of the conjugate pad.
In one embodiment thereof, a lower surface of the distal end of the sample pad is in contact with an upper surface of the leading end of the guide film; or
An upper surface of a distal end of the sample pad is in contact with a lower surface of a leading end of the guide film.
In one embodiment thereof, the lower surface of the distal end of the sample pad is in contact with the upper surface of the leading end of the conjugate pad; or
The upper surface of the distal end of the sample pad is in contact with the lower surface of the leading end of the conjugate pad.
In one embodiment thereof, a lower surface of the tip of the guide film is in contact with an upper surface of the front end of the sample pad; or
An upper surface of a tip of the guide film is in contact with a lower surface of a front end of the sample pad.
In one embodiment thereof, a lower surface of a tip end of the sample limiting membrane is in contact with an upper surface of a leading end of the guide membrane; or
An upper surface of a tip end of the sample limiting membrane is in contact with a lower surface of a leading end of the guide membrane.
In one embodiment, when the end of the absorbent pad is located on the upper surface of the base material and the front end of the absorbent pad is located on the lower surface of the base material:
the length of the absorbent pad on the upper surface of the base material is greater than that of the absorbent pad on the lower surface of the base material; or
The length of the absorbent pad on the upper surface of the base material is equal to that of the absorbent pad on the lower surface of the base material; or
The length of the absorbent pad on the upper surface of the substrate is smaller than that of the absorbent pad on the lower surface of the substrate.
In one embodiment, in the case where the front end of the chromatographic carrier is located on the upper surface of the substrate and the end of the chromatographic carrier is located on the lower surface of the substrate:
the length of the chromatographic membrane positioned on the upper surface of the substrate is greater than the length of the chromatographic membrane positioned on the lower surface of the substrate; or
The length of the chromatographic membrane positioned on the upper surface of the substrate is equal to the length of the chromatographic membrane positioned on the lower surface of the substrate; or
The length of the chromatographic membrane on the upper surface of the substrate is smaller than the length of the chromatographic membrane on the lower surface of the substrate.
In one embodiment, the inspection line and the quality control line are located on the upper surface of the substrate; or
The detection line is positioned on the upper surface of the substrate, and the quality control line is positioned on the lower surface of the substrate; or
The detection line and the quality control line are positioned on the lower surface of the substrate.
The second aspect of the present invention is to provide a biochemical test tube, wherein the biochemical test tube is provided with the biochemical test paper as described above.
In one embodiment thereof, the biochemical cuvette includes a tube portion and a cap portion;
the tube portion includes:
a sample chamber;
the biochemical test paper is arranged in the test paper fixing part;
and under the condition that the cover part seals the tube part, the top of the sample cavity is communicated with the top of the test paper fixing part, and the sample solution receiving end of the biochemical test paper is close to the cover part.
In one embodiment, the length of the biochemical test strip is greater than the height of the strip-fixing member.
In one embodiment, the difference between the length of the biochemical test paper and the height of the test paper fixing part is 1-5 mm.
In one embodiment, the axial direction of the test strip fixing member is parallel to the axial direction of the sample chamber.
In one embodiment, the number of the sample cavities is several, and the axial directions of the several sample cavities are parallel.
In one embodiment, the number of the test strip fixing parts is several, and the axial directions of the test strip fixing parts are parallel.
The utility model adopts the above technical scheme, compare with prior art, have following technological effect:
the utility model discloses a biochemical test paper and test tube utilizes transparent hollow tube cover to establish the test paper strip main part, and is isolated with test paper strip main part and external world effectively, utilizes the hydrophobic internal surface of transparent hollow tube, avoids the direct internal surface contact with biochemical test tube of test paper strip main part, prevents that the surface tension of biochemical test paper's internal surface from influencing the chromatography result of test paper strip main part.
Drawings
FIG. 1 is a schematic view of a biochemical test strip according to an embodiment of the present application;
FIG. 2 is a schematic diagram of a test strip body according to an embodiment of the present application (I);
FIG. 3 is a cross-sectional view (one) of a test strip body according to an embodiment of the present application;
FIG. 4 is a schematic diagram of a test strip body according to an embodiment of the present application (II);
FIG. 5 is a cross-sectional view of a test strip body according to an embodiment of the present application (II);
FIG. 6 is a schematic view of a biochemical test strip according to an embodiment of the present application (two);
FIG. 7 is a schematic diagram of a test strip body according to an embodiment of the present application (III);
FIG. 8 is a cross-sectional view of a test strip body according to an embodiment of the present application (III);
FIG. 9 is a schematic representation (IV) of a test strip body according to an embodiment of the present application;
FIG. 10 is a cross-sectional view (IV) of a test strip body according to an embodiment of the present application;
FIG. 11 is a schematic view (III) of a biochemical test strip according to an embodiment of the present application;
FIG. 12 is a cross-sectional view (V) of a test strip body according to an embodiment of the present application;
FIG. 13 is a schematic representation (VI) of a test strip body according to an embodiment of the present application;
FIG. 14 is a cross-sectional View (VI) of a test strip body according to an embodiment of the present application;
FIG. 15 is a schematic diagram of a test strip body according to an embodiment of the present application (seventh);
FIG. 16 is a cross-sectional view (seventh) of a test strip body according to an embodiment of the present application;
FIG. 17 is a cross-sectional view of a biochemical test tube according to an embodiment of the present application (without a biochemical test strip);
FIG. 18 is a cross-sectional view of a biochemical test tube (provided with a biochemical test strip) according to an embodiment of the present application.
Wherein the reference numerals are: the test strip comprises a test strip body 100, a substrate 101, a chromatographic membrane 102, a water absorption pad 103, a combination pad 104, a guide membrane 105, a sample pad 106, a sample limiting membrane 107, a filter pad 108, a water retaining pad 109, a transparent protective membrane 110, a detection line 111 and a quality control line 112;
a transparent hollow tube 200, an opening member 210, and a closing member 220;
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by a person of ordinary skill in the art without creative efforts belong to the protection scope of the present invention.
It should be noted that, in the present invention, the embodiments and features of the embodiments may be combined with each other without conflict.
The present invention will be further described with reference to the accompanying drawings and specific embodiments, but the present invention is not limited thereto.
Example 1
As shown in fig. 1, a biochemical test paper includes a test paper main body 100 and a transparent hollow tube 200, the transparent hollow tube 200 wraps the test paper main body 100 inside the transparent hollow tube 200, i.e. the test paper main body 100 is disposed inside the transparent hollow tube 200.
The transparent hollow tube 200 is an integral hollow tube, avoiding the fragile problem caused by a split structure.
The inner surface of the transparent hollow tube 200 is a hydrophobic surface. The transparent hollow tube 200 can prevent the test strip main body 100 from directly contacting with the inner surface of the biochemical test tube, and prevent the surface tension of the inner surface of the biochemical test tube from influencing the adsorption rate of the test strip main body 100.
The first end of the transparent hollow tube 200 is a closed end, and the second end thereof is an open end, which is provided to facilitate the movement of the test strip body 100 from the open end to the inside of the transparent hollow tube 200.
In addition, the sample solution receiving end of the strip body 100 is located at the open end of the transparent hollow tube 200.
The transparent hollow tube 200 is made of a transparent material, such as plastic or thermoplastic resin, and the test strip body 100 can be observed through the transparent hollow tube 200.
In this embodiment, the test strip body 100 is exemplified as an immunochromatographic test strip.
As shown in fig. 2 to 3, the test strip body 100 includes a substrate 101, a chromatographic carrier 102, a water-absorbing pad 103, a conjugate pad 104 and a guide membrane 105, wherein the guide membrane 105, the conjugate pad 104, the chromatographic carrier 102 and the water-absorbing pad 103 are sequentially disposed on the substrate 101.
The substrate 101 is made of plastic, such as a non-setting adhesive plastic.
The guide film 105 is disposed on the upper surface of the substrate 101, i.e., the lower surface of the guide film 105 is connected, e.g., adhered, to the upper surface of the substrate 101. The end of the guide film 105 is in contact with the front end of the conjugate pad 104, and the guide film 105 transfers the solution to the conjugate pad 104.
The upper surface of the tip of the guide film 105 is in contact with the lower surface of the front end of the bonding pad 104, or the lower surface of the tip of the guide film 105 is in contact with the upper surface of the front end of the bonding pad 104.
Wherein the guide film 105 is made of a cellulose film.
Wherein the thickness of the guide film 105 is less than 0.15 mm.
The bonding pads 104 are disposed on the upper surface of the substrate 101, i.e., the lower surface of the bonding pads 104 and the upper surface of the substrate 101 are connected, e.g., bonded. The end of the conjugate pad 104 contacts the front end of the chromatographic carrier 102, and the conjugate pad 104 transfers the solution to the chromatographic carrier 102. Specifically, the upper surface of the end of the conjugate pad 104 is in contact with the lower surface of the front end of the chromatographic carrier 102, or the lower surface of the end of the conjugate pad 104 is in contact with the upper surface of the front end of the chromatographic carrier 102.
The bonding pad 104 is a gold pad.
The bonding pad 104 is made of glass fiber, polyester film, cellulose filter paper, nonwoven fabric, or the like.
Wherein the solution chromatography speed of the guide membrane 105 is lower than that of the conjugate pad 104.
The chromatographic carrier 102 is disposed on at least the upper surface of the substrate 101, i.e., the lower surface of the chromatographic carrier 102 is connected, e.g., adhered, to the upper surface of the substrate 101. The end of the chromatographic carrier 102 is in contact with the end of the absorbent pad 103, and the chromatographic carrier 102 transfers the solution to the absorbent pad 103.
The chromatographic membrane 102 is further provided with a detection line 111 and a quality control line 112, which are sequentially arranged along the front end to the tail end of the chromatographic membrane 102.
Wherein, the chromatographic membrane 102 is made of a nitrocellulose membrane.
The absorbent pad 103 is disposed on at least the lower surface of the substrate 101, i.e., the upper surface of the absorbent pad 103 is connected to, e.g., adhered to, the lower surface of the substrate 101. The end of the absorbent pad 103 contacts the end of the chromatographic carrier 130.
Wherein the absorbent pad 103 is absorbent paper.
Wherein the end of the chromatographic carrier 102 and the end of the absorbent pad 103 are contacted at the end of the substrate 101 and solution transfer is performed.
In the first embodiment of this embodiment, the end of the chromatographic carrier 102 extends a certain distance beyond the end of the substrate 101, the end of the absorbent pad 103 extends a certain distance beyond the end of the substrate 101, and the end of the chromatographic carrier 102 and the end of the absorbent pad 103 are in contact and perform solution transfer, i.e., the lower surface of the end of the chromatographic carrier 102 and the upper surface of the end of the absorbent pad 103 are in contact and perform solution transfer. In this embodiment, the chromatographic carrier 102, the substrate 101 and the absorbent pad 103 form a sandwich structure.
In the second embodiment of this embodiment, the chromatographic carrier 102 is also disposed on the lower surface of the base material 101, i.e., the end of the chromatographic carrier 102 is bent downward at the end of the base material 101. Specifically, the upper surface of the end of the chromatographic carrier 102 and the upper surface of the end of the water absorption pad 103 are in contact and solution transfer is performed, or the lower surface of the end of the chromatographic carrier 102 and the lower surface of the end of the water absorption pad 103 are in contact and solution transfer is performed.
In this embodiment, the length of the chromatographic carrier 102 located on the upper surface of the substrate 101 is longer than the length of the chromatographic carrier 102 located on the lower surface of the substrate 101; alternatively, the length of the chromatographic carrier 102 located on the upper surface of the substrate 101 is equal to the length of the chromatographic carrier 102 located on the lower surface of the substrate 101; alternatively, the length of the chromatographic carrier 102 located on the upper surface of the substrate 101 is shorter than the length of the chromatographic carrier 102 located on the lower surface of the substrate 101.
Preferably, the length of the chromatographic carrier 102 on the upper surface of the substrate 101 is longer than the length of the chromatographic carrier 102 on the lower surface of the substrate 101
In the third embodiment of this embodiment, the absorbent pad 103 is also disposed on the upper surface of the base material 101, i.e., the end of the absorbent pad 103 is bent upward at the end of the base material 101. Specifically, the upper surface of the end of the water absorption pad 103 and the upper surface of the end of the chromatographic carrier 102 are in contact and solution transfer is performed, or the lower surface of the end of the water absorption pad 103 and the lower surface of the end of the chromatographic carrier 102 are in contact and solution transfer is performed.
In this embodiment, the length of the absorbent pad 103 located on the upper surface of the base material 101 is greater than the length of the absorbent pad 103 located on the lower surface of the base material 101; alternatively, the length of the absorbent pad 103 on the upper surface of the substrate 101 is equal to the length of the absorbent pad 103 on the lower surface of the substrate 101; alternatively, the length of the absorbent pad 103 on the upper surface of the base 101 is shorter than the length of the absorbent pad 103 on the lower surface of the base 101.
Preferably, the length of the absorbent pad 103 on the upper surface of the base material 101 is smaller than the length of the absorbent pad 103 on the lower surface of the base material 101.
In order to ensure that the end of the chromatographic carrier 102 and the end of the absorbent pad 103 are in contact with each other, a thin film is provided between the end of the chromatographic carrier 102 and the end of the absorbent pad 103. The membrane covers the chromatographic carrier 102 and the absorbent pad 103 so that the chromatographic carrier 102 and the absorbent pad 103 are kept in contact.
In this embodiment, the length of the strip body 100 is 2cm to 4cm, preferably 2.8cm, 3.0cm, 3.2cm, and 3.5 cm.
In another embodiment, as shown in fig. 4 to 5, the test strip body 100 further comprises a substrate 101, a chromatographic membrane 102, a water absorption pad 103, a binding pad 104, a guide membrane 105 and a sample limiting membrane 107, wherein the sample limiting membrane 107, the guide membrane 105, the binding pad 104, the chromatographic membrane 102 and the water absorption pad 103 are sequentially disposed on the substrate 101.
The connection relationship, structure and constitution of the substrate 101, chromatographic carrier 102, absorbent pad 103, conjugate pad 104 and guide membrane 105 are substantially the same as those of the test strip body 100.
The sample limiting film 107 is disposed on the upper surface of the substrate 101, i.e., the lower surface of the sample limiting film 107 is attached, e.g., adhered, to the upper surface of the substrate 101. The end of the sample limiting membrane 107 is in contact with the front end of the guide membrane 105, and the sample limiting membrane 107 transfers the solution to the guide membrane 105. Specifically, the upper surface of the tip end of the sample limiting film 107 is in contact with the lower surface of the leading end of the guide film 105, or the lower surface of the tip end of the sample limiting film 107 is in contact with the upper surface of the leading end of the guide film 105.
Wherein, the liquid absorption saturation volume of the sample limiting film 107 is 2-20 mul, and the sample limiting film can absorb trace samples.
The sample limiting film 107 is made of a material such as glass fiber, polyester film, or cellulose filter paper.
In this embodiment, the length of the biochemical test strip 200 is 2cm to 4cm, preferably 3.3cm, 3.5cm, and 3.7 cm.
The method of use of this example is as follows: placing the biochemical test paper into a test paper cavity of the biochemical test tube, and enabling a sample solution receiving end of the test paper main body 100 to be arranged upwards (such as a guide membrane 105 or a sample limiting membrane 107); putting a solution to be reacted into a reaction solution cavity of a biochemical test tube, and putting a diluting solution into a diluting solution cavity of the biochemical test tube; after the solution in the reaction solution cavity is reacted, the biochemical test tube is tilted to mix the reacted solution with the diluted solution to obtain a mixed solution, the mixed solution contacts the sample solution receiving end of the test strip main body 100, and the mixed solution is rapidly adsorbed to the chromatographic membrane 102 for color development under the action of the water absorption pad 103.
Example 2
As shown in fig. 6, a biochemical test paper includes a test paper main body 100 and a transparent hollow tube 200, the transparent hollow tube 200 wraps the test paper main body 100 inside the transparent hollow tube 200, i.e. the test paper main body 100 is disposed inside the transparent hollow tube 200.
The inner surface of the transparent hollow tube 200 is a hydrophobic surface. The transparent hollow tube 200 can prevent the test strip main body 100 from directly contacting with the inner surface of the biochemical test tube, and prevent the surface tension of the inner surface of the biochemical test tube from influencing the adsorption rate of the test strip main body 100.
The first end of the transparent hollow tube 200 is a closed end, and the second end thereof is an open end, which is provided to facilitate the movement of the test strip body 100 from the open end to the inside of the transparent hollow tube 200.
In addition, the sample solution receiving end of the strip body 100 is located at the open end of the transparent hollow tube 200.
The transparent hollow tube 200 is made of a transparent material, such as plastic or thermoplastic resin, and the test strip body 100 can be observed through the transparent hollow tube 200.
The transparent hollow tube 200 includes an opening part 210, and the opening part 210 is disposed at an opening end of the transparent hollow tube 200. Specifically, the first end of the opening part 210 is connected with the second end (i.e., the opening end) of the transparent hollow tube 200, and the width of the cross section of the second end of the opening part 210 is greater than the width of the cross section of the first end of the opening part 210.
In one embodiment, the width of the cross section of the opening member 210 decreases from the second end to the first end, i.e. the longitudinal section of the inside of the opening member 210 is trapezoidal, and the solid shape of the inside thereof is a truncated cone or a trapezoid.
The purpose of the opening member 210 is to facilitate the mounting of the test strip body 100 from the opening member 210 to the inside of the transparent hollow tube 200, and to improve the positioning and mounting efficiency of the test strip body 100.
After the test strip body 100 is attached to the inside of the transparent hollow tube 200, the opening member 210 of the transparent hollow tube 200 may not be treated, or the opening member 210 may be heat-treated to seal the opening member 210.
In this embodiment, the test strip body 100 is exemplified as an immunochromatographic test strip.
As shown in FIGS. 7 to 8, the test strip body 100 includes a substrate 101, a chromatographic carrier 102, a water-absorbent pad 103, a conjugate pad 104, a guide membrane 105 and a sample pad 106, wherein the sample pad 106, the guide membrane 105, the conjugate pad 104, the chromatographic carrier 102 and the water-absorbent pad 103 are disposed on the substrate 101.
The connection relationship, structure and composition of the substrate 101, the chromatographic membrane 102, the absorbent pad 103 and the conjugate pad 104 are substantially the same as those in embodiment 1, and are not described herein again.
The sample pad 106 is made of a material such as glass fiber, polyester film, cellulose filter paper, or nonwoven fabric.
In the first embodiment of this embodiment, the end of the sample pad 106 is in contact with the front end of the guide membrane 105, and the sample pad 106 transfers the solution to the guide membrane 105. Specifically, the upper surface of the tip of the sample pad 106 is in contact with the lower surface of the leading end of the guide film 105, or the lower surface of the tip of the sample pad 106 is in contact with the upper surface of the leading end of the guide film 105.
In the second embodiment of this embodiment, the front end of the sample pad 106 is in contact with the end of the guide film 105, and the guide film 105 transfers the solution to the sample pad 106. Specifically, the upper surface of the tip of the guide film 105 is in contact with the lower surface of the front end of the sample pad 106, or the lower surface of the tip of the guide film 105 is in contact with the upper surface of the front end of the sample pad 106.
The end of sample pad 106 contacts the front end of conjugate pad 104, and sample pad 106 delivers solution to conjugate pad 104. Specifically, the upper surface of the distal end of sample pad 106 is in contact with the lower surface of the front end of conjugate pad 104, or the lower surface of the distal end of sample pad 106 is in contact with the upper surface of the front end of conjugate pad 104.
In the third embodiment of this embodiment, the test strip body 100 includes two guide films 105 respectively disposed on the front and rear sides of the sample pad 106, i.e., the end of the first guide film 105 contacts the front end of the sample pad 106, and the first guide film 105 transmits the solution to the sample pad 106. Specifically, the upper surface of the tip of the first guide film 105 is in contact with the lower surface of the front end of the sample pad 106, or the lower surface of the tip of the first guide film 105 is in contact with the upper surface of the front end of the sample pad 106.
The end of the sample pad 106 is in contact with the second guide membrane 105, and the sample pad 106 transfers the solution to the second guide membrane 105. The upper surface of the tip of the sample pad 106 is in contact with the lower surface of the leading end of the second guide film 105, or the lower surface of the tip of the sample pad 106 is in contact with the upper surface of the leading end of the second guide film 105.
Wherein, in the case where there is only one guide film 105, the guide film 105 may be a first guide film; in the case where the guide membranes 105 are two, the guide membrane 105 near the chromatographic carrier 102 may be a first guide membrane, and the guide membrane far from the chromatographic carrier 102 may be a second guide membrane.
In the present embodiment, the solution chromatography speed of the sample pad 106 is greater than that of the guide membrane 105.
In another embodiment, as shown in fig. 9-10, the test strip body 100 comprises a substrate 101, a chromatographic membrane 102, a water absorbent pad 103, a conjugate pad 104, a guide membrane 105, a sample pad 106, and a sample limiting membrane 107, wherein the sample limiting membrane 107, the sample pad 106, the first guide membrane 105, the conjugate pad 104, the chromatographic membrane 102, and the water absorbent pad 103 are disposed on the substrate 101.
The connection relationship, structure and composition of the substrate 101, the chromatographic membrane 102, the absorbent pad 103, the conjugate pad 104, the guide membrane 105 and the sample pad 260 are substantially the same as those of the second and third embodiments of this embodiment, and are not described herein again.
The sample limiting film 107 is disposed on the upper surface of the substrate 101, i.e., the lower surface of the sample limiting film 107 is attached, e.g., adhered, to the upper surface of the substrate 101. The end of the sample limiting membrane 107 is in contact with the front end of the guide membrane 105, and the sample limiting membrane 107 transfers the solution to the guide membrane 105. Specifically, the upper surface of the tip end of the sample limiting film 107 is in contact with the lower surface of the leading end of the guide film 105, or the lower surface of the tip end of the sample limiting film 107 is in contact with the upper surface of the leading end of the guide film 105.
Wherein, the liquid absorption saturation volume of the sample limiting film 107 is 2-20 mul, and the sample limiting film can absorb trace samples.
The sample limiting film 107 is made of a material such as glass fiber, polyester film, or cellulose filter paper.
In this embodiment, the length of the biochemical test strip 200 is 2cm to 4cm, preferably 3.6cm and 3.8 cm.
The method of use of this example is as follows: placing the biochemical test paper into a test paper cavity of the biochemical test tube, and enabling a sample solution receiving end of the test paper main body 100 to be arranged upwards (such as a sample pad 106, a guide membrane 105 or a sample limiting membrane 107); putting a solution to be reacted into a reaction solution cavity of a biochemical test tube, and putting a diluting solution into a diluting solution cavity of the biochemical test tube; after the solution in the reaction solution cavity is reacted, the biochemical test tube is tilted to mix the reacted solution with the diluted solution to obtain a mixed solution, the mixed solution contacts the sample solution receiving end of the test strip main body 100, and the mixed solution is rapidly adsorbed to the chromatographic membrane 102 for color development under the action of the water absorption pad 103.
Example 3
As shown in fig. 11, a biochemical test paper includes a test paper main body 100 and a transparent hollow tube 200, including the test paper main body 100 and the transparent hollow tube 200, the transparent hollow tube 200 wraps the test paper main body 100 inside the transparent hollow tube 200, i.e. the test paper main body 100 is disposed inside the transparent hollow tube 200.
The inner surface of the transparent hollow tube 200 is a hydrophobic surface. The transparent hollow tube 200 can prevent the test strip main body 100 from directly contacting with the inner surface of the biochemical test tube, and prevent the surface tension of the inner surface of the biochemical test tube from influencing the adsorption rate of the test strip main body 100.
The first end of the transparent hollow tube 200 is a closed end, and the second end thereof is an open end, which is provided to facilitate the movement of the test strip body 100 from the open end to the inside of the transparent hollow tube 200.
In addition, the sample solution receiving end of the strip body 100 is located at the open end of the transparent hollow tube 200.
The transparent hollow tube 200 is made of a transparent material, such as plastic or thermoplastic resin, and the test strip body 100 can be observed through the transparent hollow tube 200.
The transparent hollow tube 200 includes an opening part 210 and a closing part 220, and the closing part 220 is disposed at a second end of the opening part 220 for closing the opening part 210.
The connection relationship and structure of the opening part 210 are substantially the same as those of embodiment 2, and are not described herein again.
Wherein, the closing component 220 is any one of a snap patch, a zipper, a concave-convex bone and a locking ring. When the sealing member 220 is an uneven bone, the transparent hollow tube 200 may be a bone-blowing transparent hollow tube or a bone-sticking transparent hollow tube.
In this embodiment, the test strip body 100 is exemplified as an immunochromatographic test strip.
As shown in fig. 12, the test strip body 100 includes a substrate 101, a chromatographic carrier 102, a water absorbent pad 103, a conjugate pad 104, a guide membrane 105, and a transparent protective film 110, wherein the guide membrane 105, the conjugate pad 104, the chromatographic carrier 102, and the water absorbent pad 103 are sequentially disposed on the substrate 101.
The connection relationship, structure and composition of the base material 101, the chromatographic membrane 102, the absorbent pad 103, the combination pad 104 and the guide membrane 105 are substantially the same as those of embodiment 1, and are not repeated herein.
The lower surface of the transparent protective film 110 covers at least the conjugate pad 104 and the chromatographic carrier 102.
In this embodiment, the transparent protective film 110 can prevent the binding pad 104 and the chromatographic carrier 102 from contacting with the exogenous aqueous mixture, thereby improving the accuracy of the detection result of the chromatographic strip.
In addition, the transparent protective film 110 can be applied to the biochemical test paper of example 2.
Example 4
A biochemical test paper comprises a test paper main body 100 and a transparent hollow tube 200, and comprises the test paper main body 100 and the transparent hollow tube 200, wherein the transparent hollow tube 200 wraps the test paper main body 100 inside the transparent hollow tube 200, namely the test paper main body 100 is arranged inside the transparent hollow tube 200.
The structure and constitution of the transparent hollow tube 200 are substantially the same as those of embodiments 1 to 3, and are not described herein again.
In this embodiment, the test strip body 100 is exemplified as an immunochromatographic test strip.
As shown in fig. 13 to 14, a test strip body 100 includes a substrate 101, a chromatographic membrane 102, a water absorption pad 103, a binding pad 104, a guide membrane 105 and a filter pad 108, wherein the guide membrane 105, the filter pad 108, the binding pad 104, the chromatographic membrane 102 and the water absorption pad 103 are sequentially disposed on the substrate 101.
The connection relationship, structure and composition of the base material 101, the chromatographic membrane 102, the absorbent pad 103 and the conjugate pad 104 are substantially the same as those in embodiment 1, and are not described herein again.
The method of use of this example is as follows: after the sample solution contacts the guide film 105, it slowly flows forward over the guide film 105; the guide membrane 105 delivers the sample solution to the filter pad 108; the sample solution is filtered through the filter pad 108 and transferred to the conjugate pad 104; on the conjugate pad 104, the sample solution and the colloidal gold particles are bound and rapidly flow toward the chromatographic carrier 102; under the action of the absorbent pad 103, the sample solution flows on the chromatographic membrane 102 in the direction of the absorbent pad 103, and develops color on the chromatographic membrane 102; according to the results of the detection line 111 and the quality control line 112, whether the sample solution is positive or negative can be determined.
Example 5
A biochemical test paper comprises a test paper main body 100 and a transparent hollow tube 200, and comprises the test paper main body 100 and the transparent hollow tube 200, wherein the transparent hollow tube 200 wraps the test paper main body 100 inside the transparent hollow tube 200, namely the test paper main body 100 is arranged inside the transparent hollow tube 200.
The structure and constitution of the transparent hollow tube 200 are substantially the same as those of embodiments 1 to 3, and are not described herein again.
In this embodiment, the test strip body 100 is exemplified as an immunochromatographic test strip.
As shown in fig. 15 to 16, a test strip body 100 includes a substrate 101, a chromatographic membrane 102, a water absorption pad 103, a combination pad 104, a guide membrane 105 and a water blocking pad 109, wherein the guide membrane 105, the combination pad 104, the chromatographic membrane 102 and the water absorption pad 103 are sequentially disposed on the substrate 101.
The connection relationship, structure and composition of the base material 101, the chromatographic membrane 102, the absorbent pad 103, the combination pad 104 and the guide membrane 105 are substantially the same as those of embodiment 1, and are not repeated herein.
The water blocking pad 109 is disposed on the guide film 105 and is disposed near the front end of the guide film 105, i.e., the lower surface of the water blocking pad 109 is attached, e.g., bonded, to the upper surface of the guide film 105.
The water blocking pad 109 has a certain length and thickness, and is used to fill a gap between the immunochromatographic test strip 100 and the test strip placement cavity when the immunochromatographic test strip 100 is inserted into the test strip placement cavity (or the test strip placement member) of the immunochromatographic test tube, so as to prevent liquid from directly entering the test strip placement cavity without being guided by the guide film 105, and prevent the unmixed liquid from directly contacting the conjugate pad 104 or the chromatographic film 102.
The using method of this embodiment is basically the same as that of embodiment 1, and is not described herein again.
The water retaining pad 109 may be applied to the immunochromatographic test strip 100 of examples 2 to 4.
Example 6
The present embodiment relates to a biochemical test tube to which the biochemical test paper of embodiments 1 to 5 is attached.
As shown in FIGS. 17 to 18, a biochemical test tube 300 includes a tube part 310, a cap part 320, and a coupling part 330, wherein the tube part 310 and the cap part 320 are coupled by the coupling part 330.
The tube portion 310 includes a sample chamber 311 and a test strip fixing member 312, wherein the biochemical test strip 100 is placed in the test strip fixing member 312.
Wherein the axis of the strip fixing member 312 is parallel to the axis of the sample chamber 311.
The sample cavity 311 is a regular-shaped cavity (e.g., a circular cavity, a rectangular cavity, a trapezoidal cavity) or an irregular-shaped cavity. The reagent holding member 312 may be a regular-shaped chamber (e.g., a circular chamber, a rectangular chamber, a trapezoidal chamber) or an irregular shape.
As shown in fig. 18, in a state where the cap 320 closes the tube 310, the sample chamber 311 communicates with the top of the strip fixing part 312, and the sample solution receiving end (e.g., the guide membrane 105, the sample pad 106, or the sample limiting membrane 107) of the strip body 100 is close to the inner bottom surface of the cap 320 for contacting and adsorbing the substance in the sample chamber 311 in a state where the biochemical test tube 300 is inclined at a certain angle. The substance in the sample cavity 311 includes, but is not limited to, a biochemical reaction reagent or a biochemical reaction solution.
The length of the strip body 100 is greater than the height of the strip fixing member 312. In general, the difference between the length of the strip body 100 and the height of the strip fixing member 312 is 1mm to 5mm, and preferably 2mm to 3 mm.
In one embodiment, the sample cavity 311 may be a plurality of cavities, the axes of the plurality of sample cavities 311 are parallel, at least one sample cavity 311 is used for placing biochemical reaction reagents or biochemical reaction solutions, and at least one sample cavity 311 is used for placing functional reaction reagents. The functional reagent includes, but is not limited to, degrading enzyme, lysis solution, probe, buffer solution, diluent, etc., or a reagent for performing a subsequent reaction after the biochemical reaction is completed.
In one embodiment, the test strip fixing member 312 may be a plurality of test strip fixing members 312, the axes of the plurality of test strip fixing members 312 are parallel, and an immunochromatographic test strip is placed in each test strip fixing member 312, so that different indicators of the same sample can be detected at the same time.
The cover 320 includes a cavity 321, and the cavity 122 is formed by an inner surface of the cover 120 protruding outward for receiving the biochemical test strip protruding from the top of the test strip fixing member 312.
Wherein the longitudinal section of the cavity 321 is trapezoidal, circular arc or triangular.
In this embodiment, since the length of the strip body 100 is shorter, the length of the biochemical test tube 300 is also shortened accordingly. From the perspective of large-scale mass production, a large amount of production materials and production cost can be saved.
The above description is only an example of the preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and those skilled in the art should be able to realize the equivalent alternatives and obvious variations of the present invention.
Claims (10)
1. A biochemical test strip, comprising:
a test strip body;
the test strip comprises a transparent hollow tube, wherein the transparent hollow tube is an integrated hollow tube, the test strip main body is arranged inside the transparent hollow tube, and the inner surface of the transparent hollow tube is a hydrophobic surface.
2. The biochemical test strip according to claim 1, wherein the first end of the transparent hollow tube is a closed end.
3. The biochemical test strip according to claim 2, wherein the transparent hollow tube comprises:
an open member, a first end of the open member being connected to a second end of the transparent hollow tube;
the width of the cross section of the second end of the opening part is larger than the width of the cross section of the first end of the opening part.
4. The biochemical test strip according to claim 3, wherein the width of the cross section of the opening member decreases from the second end of the opening member toward the first end of the opening member.
5. The biochemical test strip according to claim 1, wherein the test strip body comprises:
a substrate;
a chromatographic membrane disposed on an upper surface of the substrate;
the water absorption pad is arranged on the lower surface of the base material;
wherein the chromatographic membrane and the absorbent pad are contacted at the end of the substrate and solution transfer is performed.
6. The biochemical test strip of claim 5, wherein the test strip body further comprises:
a conjugate pad disposed on the substrate, an end of the conjugate pad contacting a front end of the chromatographic membrane and delivering a solution to the chromatographic membrane;
a guide film disposed on the substrate, a distal end of the guide film contacting a front end of the conjugate pad and transferring a solution to the conjugate pad;
wherein the solution chromatography speed of the guide membrane is less than that of the binding pad.
7. A biochemical test tube, wherein the biochemical test tube is provided with the biochemical test paper according to any one of claims 1 to 6.
8. The biochemical cuvette according to claim 7, wherein the biochemical cuvette comprises a tube portion and a cap portion;
the tube portion includes:
a sample chamber;
the biochemical test paper is arranged in the test paper fixing part;
and under the condition that the cover part seals the tube part, the top of the sample cavity is communicated with the top of the test paper fixing part, and the sample solution receiving end of the biochemical test paper is close to the cover part.
9. The biochemical cuvette according to claim 8, wherein the biochemical test strip has a length greater than a height of the strip holding member.
10. The biochemical cuvette of claim 8, wherein the cover comprises:
a cavity formed by an inner surface of the cover portion bulging outward.
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|---|---|---|---|
| CN202021152072.5U CN212722908U (en) | 2020-06-19 | 2020-06-19 | Biochemical test paper and test tube |
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| CN202021152072.5U CN212722908U (en) | 2020-06-19 | 2020-06-19 | Biochemical test paper and test tube |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021254513A1 (en) * | 2020-06-19 | 2021-12-23 | 上海快灵生物科技有限公司 | Biochemical test paper tube |
| WO2021254514A1 (en) * | 2020-06-19 | 2021-12-23 | 上海快灵生物科技有限公司 | Biochemical test paper tube |
-
2020
- 2020-06-19 CN CN202021152072.5U patent/CN212722908U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021254513A1 (en) * | 2020-06-19 | 2021-12-23 | 上海快灵生物科技有限公司 | Biochemical test paper tube |
| WO2021254514A1 (en) * | 2020-06-19 | 2021-12-23 | 上海快灵生物科技有限公司 | Biochemical test paper tube |
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