WO2021250940A1 - 自動分析装置 - Google Patents

自動分析装置 Download PDF

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Publication number
WO2021250940A1
WO2021250940A1 PCT/JP2021/004440 JP2021004440W WO2021250940A1 WO 2021250940 A1 WO2021250940 A1 WO 2021250940A1 JP 2021004440 W JP2021004440 W JP 2021004440W WO 2021250940 A1 WO2021250940 A1 WO 2021250940A1
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WO
WIPO (PCT)
Prior art keywords
reaction
reaction disk
disk
automatic analyzer
drive rotor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2021/004440
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English (en)
French (fr)
Japanese (ja)
Inventor
理絵 堀内
晃啓 安居
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi High Tech Corp
Original Assignee
Hitachi High Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi High Tech Corp filed Critical Hitachi High Tech Corp
Priority to EP21820090.5A priority Critical patent/EP4163640A4/en
Priority to US18/007,598 priority patent/US20230258674A1/en
Priority to CN202180038217.XA priority patent/CN115769082A/zh
Priority to JP2022530022A priority patent/JP7447261B2/ja
Publication of WO2021250940A1 publication Critical patent/WO2021250940A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0406—Individual bottles or tubes
    • G01N2035/041—Individual bottles or tubes lifting items out of a rack for access
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0441—Rotary sample carriers, i.e. carousels for samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0444—Rotary sample carriers, i.e. carousels for cuvettes or reaction vessels

Definitions

  • the present invention relates to an automatic analyzer that analyzes a sample using a reaction cell.
  • Automatic analyzers such as biochemical analyzers and immunoassays are known as devices for analyzing samples such as blood and urine collected from patients.
  • reaction cells are used to mix and react the sample and the reagent.
  • the reaction cell is a consumable item that needs to be replaced at predetermined intervals.
  • One of the automatic analyzers that needs to replace the reaction cell at regular intervals is an automatic biochemical analyzer that uses a turntable-like mechanism called a reaction disk.
  • a plurality of reaction cells are mounted on the outer peripheral portion of the reaction disk, and the reaction cells are arranged in a ring shape.
  • the reaction cell installed on the reaction disk is located inside a donut-shaped pool called a reaction tank, and is immersed in a liquid kept at a constant temperature inside the reaction tank.
  • a light source lamp for measuring the absorbance is closely arranged in the annular row of the reaction cells. Since the reaction cell is disposable, it needs to be replaced at regular intervals, but the reaction tank and light source lamp also require maintenance by the user.
  • the reaction tank needs to be cleaned at regular intervals, and the light source lamp needs to be replaced at regular intervals.
  • the user When cleaning the reaction vessel, the user needs to drain the liquid in the reaction vessel, for example, remove the reaction cell from the reaction disk so that the reaction vessel can be reached. If the light source lamp is installed underneath the reaction disc, the user must remove the reaction disc from the automated analyzer when replacing the light source lamp. In this case as well, all reaction cells must be removed from the reaction disk before removing the reaction disk. Since all the reaction cells must be removed every time the reaction tank is cleaned or the light source lamp is replaced, these maintenances require time and labor. In particular, in an automatic analyzer with a large radius of a reaction disk, the number of reaction cells increases accordingly, which increases the work load required for maintenance.
  • Patent Document 1 discloses a reaction disk that is supposed to be removed from the automatic analyzer with the reaction cell attached.
  • the reaction disc is mounted from above on the top of the rotor that rotates around the vertical axis. Therefore, it is necessary to lift the reaction disk vertically when removing it from the rotor. However, it is difficult to lift the reaction disk accurately and vertically, and the operation of lifting the reaction disk involves not a little camera shake. It is difficult to remove the reaction disc without any interference with the rotor, and the reaction disc interferes with the rotor in small steps during the lifting process. The same applies when attaching the reaction disk to the rotor. This phenomenon becomes more remarkable as the radius of the reaction disk is larger and the fitting tolerance between the reaction disk and the rotor is smaller.
  • the stirring mechanism, cleaning mechanism, and wiring of these electrical devices are also densely packed in the area of the reaction tank. Therefore, when the reaction disk is pulled out from the rotor with the reaction cell attached, if the reaction disk is lifted while moving in small steps in the horizontal direction, the reaction cell may interfere with peripheral parts such as a stirring mechanism and wiring. The same applies when a reaction disk is attached.
  • the peripheral parts are generally made of the same resin as the reaction cell or a metal with a higher hardness. Interference between the reaction cell and peripheral parts may damage the reaction cell or its peripheral parts. In this case, the accuracy of analysis of the sample may decrease, and in extreme cases, analysis may not be possible.
  • the reaction cell immersed in the liquid in the reaction tank is removed from the rotor together with the reaction disk, the liquid adhering to the outer wall of the reaction cell may drip onto the peripheral parts.
  • the light emitting surface of the light source lamp may become dirty and cloudy, or the wiring may be short-circuited. After all, the analysis accuracy of the sample may decrease or the analysis may become impossible.
  • An object of the present invention is to provide an automatic analyzer capable of attaching and detaching a reaction disk while the reaction cell is attached for efficient maintenance, and protecting the reaction cell and peripheral parts when the reaction disk is attached and detached. To do.
  • the present invention comprises a drive rotor having a center of rotation extended up and down, a reaction disk mounted on the drive rotor, and an annular row installed on the reaction disk and concentric with the drive rotor.
  • an automatic analyzer including a plurality of reaction cells to be formed, an annular reaction tank accommodating the reaction cells, and a guide for guiding an ascending / descending trajectory of the reaction disk with respect to the drive rotor.
  • the reaction disk can be attached and detached for efficient maintenance with the reaction cell attached, and the reaction cell and peripheral parts can be protected when the reaction disk is attached and detached.
  • FIG. 1 Schematic diagram showing the overall configuration of an automatic analysis system including the automatic analysis device according to the first embodiment of the present invention.
  • FIG. 1 shows the state which lifted up the reaction disk provided in the automatic analyzer which concerns on 1st Embodiment of this invention.
  • FIG. 1 is a schematic diagram showing an overall configuration of an automatic analysis system including the automatic analysis device according to the first embodiment of the present invention.
  • the automatic analysis system 1000 shown in the figure is a system for measuring biochemical items for qualitative and quantitative analysis of biological samples such as blood and urine, and includes an automatic analysis device 100, a transfer unit 200, and a control device 300. It is configured.
  • the transport unit 200 is a device for charging the sample rack R into the automatic analysis system 1000 and collecting the sample rack R, and also plays a role of transporting the sample rack R to the automatic analysis device 100. At least one sample container containing a sample is mounted on the sample rack R.
  • the transport unit 200 is not limited to the type (rack type) in which the sample container is mounted on the sample rack R and loaded by the transport line 202 (described later) or the like, and the sample container is set on the disk and loaded by rotating the disk.
  • the type (disk type) that can be used is also applicable.
  • the transfer unit 200 includes a rack supply unit 201, a transfer line 202, a rack buffer 203, a rack storage unit 204, and a controller 205 for transfer control.
  • the sample rack R installed in the rack supply unit 201 is transferred to the rack buffer 203 by the transfer line 202.
  • the barcode attached to the sample container is read by a barcode reader (not shown), and the identification information of the sample is recognized. The patient is also identified by this identification information.
  • the method of recognizing the identification information of the sample is not limited to the one using the barcode.
  • the position of which sample rack is set is registered for each sample container, and the sample rack equipped with the designated sample container is transported by the transport unit 200. In this case, it is possible to omit the attachment of the barcode to the sample container and the barcode reader.
  • the rack buffer 203 is a turntable-like device that rotates around a vertical axis, and a plurality of sample racks R are held on the outer peripheral portion of the rack buffer 203.
  • the sample rack R held in the rack buffer 203 takes a posture extending in the radial direction of the rack buffer 203, and is arranged in a ring shape and in a radial pattern.
  • the transport line 202 and the sample dispensing line 13 (described later) are connected to the rack buffer 203 from the radial direction at different positions in the circumferential direction.
  • a motor By rotating the rack buffer 203 by a motor (not shown), the target sample rack R can be delivered to and from the transfer line 202 and the sample dispensing line 13 (described later).
  • the target sample rack R (for example, one having a high priority) can be sent from the rack buffer 203 to the sample dispensing line 13 regardless of the order in which the samples are received from the transport line 202 to the rack buffer 203.
  • the sample rack R that has finished sucking the sample in the sample dispensing line 13 is transported to the rack storage unit 204 via the rack buffer 203 and the transport line 202. Further, the sample rack R that has finished sucking the sample in the sample dispensing line 13 returns to the rack buffer 203 and waits until the measurement result is output by the automatic analyzer 100, and if the need for re-inspection arises, the sample is separated. Note: It may be sent back to line 13.
  • the controller 205 is a computer that controls the transfer unit 200, and transfers the sample rack R from the rack buffer 203 to the sample dispensing line 13, a transfer operation of the sample rack R from the sample dispensing line 13 to the rack buffer 203, and the like. To execute.
  • the control device 300 is a computer that controls the automatic analyzer 100 and the transfer unit 200, and is connected to the automatic analyzer 100 (controller 9 described later) and the transfer unit 200 (controller 205) by a wired or wireless network line. ing.
  • the control device 300 includes a monitor 301 and a user interface 302.
  • the monitor 301 displays a screen for ordering measurement items for each sample, a screen for confirming measurement results, and the like.
  • the user interface 302 is an input device for inputting various instructions by the user, and various input devices such as a keyboard, a mouse, and a touch panel can be appropriately adopted as the user interface 302.
  • FIG. 2 is a perspective view schematically showing the appearance of the automatic analyzer 100.
  • the figure shows an example in which a biochemical analyzer equipped with a biochemical analysis unit for measuring biochemical items is adopted as the automatic analyzer 100, but for example, an immunoanalyzer or the like may be adopted as the automatic analyzer 100.
  • the automatic analyzer 100 is a unit that measures items ordered for each sample and outputs the measurement result, and is structurally connected to the transport unit 200.
  • the automatic analyzer 100 includes a reaction disk 1, a reagent disk 2, a sample probe 3, a reagent probe 4, a cleaning mechanism 5, an ISE analyzer 6, a stirring mechanism 7 (FIG. 3), a biochemical measuring instrument 8 (FIG. 1), and a controller. It is configured to include 9 (FIG. 1) and the like.
  • the reaction disk 1 is a turntable-shaped part that rotates around a vertical axis.
  • a plurality of reaction cells 11 are installed on the outer peripheral portion of the reaction disk 1, and the plurality of reaction cells 11 form a circular row.
  • the reaction cell is an elongated disposable container made of a chemical resistant resin having an open upper portion, and extends up and down while being attached to the reaction disk 1.
  • a sample suction position 12 is set in the vicinity of the reaction disk 1.
  • a sample dispensing line 13 (FIG. 1) for transporting the sample rack R (FIG. 1) is installed so as to overlap the sample suction position 12.
  • the sample container (not shown) mounted on the sample rack R contains a patient's biological sample such as blood or urine, a standard solution for preparing a calibration curve, or a sample for quality control.
  • the sample dispensing line 13 conveys the sample rack R received from the rack buffer 203 to the sample suction position 12, and returns the sample rack R after dispensing to the rack buffer 203.
  • the reagent disc 2 is a turntable-shaped device that rotates around a vertical axis, and a plurality of reagent bottles (not shown) containing reagents can be installed in a ring shape.
  • the reagent disk 2 plays the role of a reagent storage and has a function of keeping the stored reagent cool. Further, the reagent disk 2 is covered with a cover provided with a suction port 2a.
  • the sample probe 3 is an element for dispensing a sample or the like from the sample container to the reaction cell 11, is located between the reaction disk 1 and the sample suction position 12, extends vertically, and rotates in the horizontal direction and in the vertical direction. It is configured to allow translation to.
  • a syringe (not shown) for sucking a sample or the like is connected to the sample probe 3.
  • the sample probe 3 is inserted into the sample container carried into the sample suction position 12, sucks the sample or the like with a syringe, and then draws an arc around the rotation axis on the annular row of the reaction cell 11 of the reaction disk 1. Moving.
  • the target reaction cell 11 is conveyed to the dispensing position of the sample probe 3 by the reaction disk 1, the sample probe 3 descends, is inserted into the target reaction cell 11, and the sample or the like is discharged (dispensed) by a syringe.
  • a dedicated cleaning tank is installed on the moving path of the sample probe 3, so that the sample probe 3 can be cleaned in the cleaning tank.
  • the reagent probe 4 is an element for dispensing the reagent from the reagent bottle to the reaction cell 11, is located between the reaction disk 1 and the reagent disk 2, and can rotate and move up and down in the same manner as the sample probe 3. It has a similar configuration.
  • a syringe for suctioning reagents (not shown) is connected to the reagent probe 4.
  • the target reagent bottle is conveyed directly under the suction port 2a of the reagent disk 2, the reagent probe 4 is inserted into the target reagent bottle through the suction port 2a, and the reagent is sucked by the syringe. After that, the reagent probe 4 moves on the cyclic row of the reaction cell 11 of the reaction disk 1.
  • the target reaction cell 11 is conveyed to the dispensing position of the reagent probe 4 by the reaction disk 1, the reagent probe 4 descends, is inserted into the target reaction cell 11, and the reagent is discharged (dispensed) by a syringe.
  • a dedicated washing tank is installed on the moving path of the reagent probe 4, and the reagent probe 4 can be washed in the washing tank.
  • the cleaning mechanism 5 is a mechanism for cleaning the reaction cell 11, and is arranged close to the reaction cell 11 installed on the reaction disk 1.
  • a cleaning pump (not shown) is connected to the cleaning mechanism 5, and a detergent such as an alkaline detergent or an acidic detergent is dispensed from the detergent container 14 to the reaction cell 11.
  • the ISE analyzer 6 is a device that measures the electrolyte concentration in the sample using an ion-selective electrode, is located on the moving path of the sample probe 3, and is covered with a cover provided with a dispensing port 6a.
  • the sample probe 3 is inserted into the ISE dilution tank (not shown) through the dispensing port 6a, and the sample sucked from the sample container is dispensed into the ISE dilution layer.
  • the ISE reagent is sent from the ISE reagent container 15 to the ISE dilution tank, whereby the analysis of the ISE items is executed.
  • the stirring mechanism 7 (FIG. 3) is a device for stirring the liquid (sample, reagent, etc.) contained in the reaction cell 11, and is installed inside the reaction tank 30 (FIG. 3) and is installed in the reaction disk 1. It is arranged close to the cell 11.
  • the stirring mechanism 7 is a non-contact type, and the liquid inside the reaction cell 11 is stirred without touching the reaction cell 11 or the liquid inside the reaction cell.
  • An example of the stirring mechanism 7 is an ultrasonic stirring mechanism, in which the liquid inside the reaction cell 11 is irradiated with ultrasonic waves from the outside of the reaction cell 11 to stir the liquid.
  • the biochemical measuring instrument 8 is an analyzer that analyzes the biochemical components in the sample, and is arranged close to the reaction cell 11 installed in the reaction disk 1.
  • the biochemical measuring instrument 8 comprises a light source lamp 8a (FIG. 3), a spectrophotometer, etc., and measures the absorbance of the reaction solution obtained by stirring and mixing the sample and the reagent inside the reaction cell 11 to measure the biochemical components in the sample. To analyze.
  • the controller 9 (FIG. 1) is a computer connected to each of the above devices to control the operation of the automatic analysis device 100 and transmit the analysis result to the control device 300, and includes a CPU, a memory, and the like. ing.
  • the controller 9 is connected to the control device 300 via a network line, and sends and receives signals and data to and from the control device 300.
  • the sample racks R installed in the rack supply unit 201 are sent out one rack at a time onto the transport line 202 and carried into the rack buffer 203.
  • the rack buffer 203 is controlled by the controller 205 in response to an instruction from the control device 300, and the sample rack R on which the target sample container is placed on the sample dispensing line 13 is carried out from the rack buffer 203.
  • the sample rack R is conveyed by the sample dispensing line 13 and the target sample container arrives at the sample suction position 12, the sample is dispensed from the target sample container to the reaction cell 11 by the sample probe 3.
  • the reagent sucked from the reagent bottle of the reagent disk 2 is dispensed by the reagent probe 4 to the reaction cell 11 into which the sample is dispensed.
  • the sample and reagent inside the reaction cell 11 are stirred by the stirring mechanism 7, whereby a reaction solution is generated.
  • the absorbance of the reaction solution is measured by the biochemical measuring instrument 8, and the measurement result is transmitted from the controller 9 to the control device 300.
  • the reaction cell 11 used for the analysis is washed with the detergent dispensed from the washing mechanism 5 and waits until the next use opportunity.
  • the control device 300 performs arithmetic processing on the received measurement result to obtain the concentration of the specific component contained in the sample, and displays and outputs the result on the monitor 301 or records it in the memory.
  • FIG. 3 is a cross-sectional view of the reaction disk and its peripheral parts cut along a plane including the rotation center line of the reaction disk
  • FIG. 4 is an enlarged view of a main part of FIG.
  • FIG. 5 is a perspective view of the segment of the reaction cell as viewed from above
  • FIG. 6 is a perspective view of the segment as viewed from below.
  • FIG. 7 is a diagram showing a state in which the reaction disk is lifted up, and is a diagram corresponding to FIG. 4.
  • the automatic analyzer 100 includes a drive rotor 20, a reaction tank 30, a guide 40, and a screw 50 as components arranged around the reaction disk 1. It is equipped.
  • the drive rotor 20 is a rotating body having a rotation center line extended vertically, and includes a drive disk 21 and a shaft 22.
  • the drive disk 21 is formed in a disk shape
  • the shaft 22 is formed in a columnar shape.
  • the drive disk 21 and the shaft 22 are integrally formed, and a vertically extending shaft 22 is located at the center of a disk-shaped drive disk 21 extending along a horizontal plane and protrudes above and below the drive disk 21.
  • the reaction disk 1 is concentric with the drive disk 20, and is mounted on top of the drive disk 21 so that the drive disk 21 and the facing surfaces thereof are in wide contact with each other.
  • the facing surface of the reaction disk 1 and the drive disk 21 is a flat surface in this embodiment.
  • a plurality of reaction cells 11 are installed on the outer peripheral portion of the reaction disk 1 to form an annular row concentric with the drive rotor 20.
  • Rotational power is transmitted to the shaft 22 by a motor (not shown), whereby the drive rotor 20 rotates and the reaction cell 11 moves in a circle.
  • the motor that drives the drive rotor 20 is driven by a command signal given from the controller 9 according to the order of dispensing samples and reagents output from the control device 300, the reaction time required for measurement, and the like.
  • the reaction cells 11 may be individually mounted on the reaction disk 1, but in the present embodiment, a plurality of reaction cells 11 are segmented as shown in FIGS. 5 and 6. It is adopted. By mounting a plurality of segments 11A having a plurality of reaction cells 11 arranged in an arc shape side by side in the circumferential direction on the outer peripheral portion of the reaction disk 1, an annular row of the reaction cells 11 is formed.
  • the segment 11A is provided with a through hole 11b (FIG. 5), and the segment 11A is fixed to the reaction disk 1 by passing a screw (not shown) through the through hole 11b and screwing it into the reaction disk 1.
  • the fixing structure of the segment 11A to the reaction disk 1 is not limited, and other fixing structures such as stoppers and clamps can be appropriately substituted.
  • reaction vessel 30 is a donut-shaped pool accommodating the reaction cell 11, and the reaction cell 11 is immersed in the circulating liquid stored in the reaction vessel 30 during the analysis operation.
  • a typical example of the liquid stored in the reaction tank 30 is water, but other liquids such as oil may be used.
  • the above-mentioned stirring mechanism 7 is one of the internal components installed inside the reaction tank 30, and as shown in FIG. 4, the reaction cell is more than the wall surface (inner wall on the inner peripheral side and the outer peripheral side) of the reaction tank 30. It is approaching 11.
  • the stirring mechanism 7 is described as an example of the parts inside the tank, but instead of the stirring mechanism 7 or in addition to the stirring mechanism 7, a fixed base (not shown) of the cleaning mechanism 5 is inside the reaction tank 30. In some cases, they are arranged to form the parts inside the tank.
  • the light source lamp 8a is a component of the biochemical measuring instrument 8 described above, and is arranged close to the reaction tank 30 on the inner peripheral side of the donut-shaped reaction tank 30 and below the reaction disk 1.
  • the inspection light from the light source lamp 8a is applied to the reaction cell 11 through a transmission window (not shown) provided in the reaction tank 30.
  • the light source lamp 8a is arranged at a position not vertically overlapping with the drive disk 21, and the user can easily reach the light source lamp 8a by removing the reaction disk 1 from the drive rotor 20. There is.
  • the guide 40 is an element that guides an ascending / descending trajectory in which the reaction disk 1 moves up and down in parallel with the drive rotor 20, and in this embodiment, a columnar pin is adopted.
  • the guide 40 may be a member separate from the drive disk 21, or may be integrally molded with the drive disk 21.
  • the guide 40 is provided so as to project vertically upward from the upper surface of the drive disk 21, and penetrates the pin hole 1a provided in the reaction disk 1.
  • a configuration in which a pin hole 1a is provided in the drive disk 21 and a guide 40 is provided in the reaction disk 1 is conceivable, but the configuration shown in FIG. 3 is preferable in that the guide 40 can be seen from above in the pin hole 1a.
  • the guide 40 and the pin hole 1a may be one set, but may be a plurality of sets.
  • the sizes and shapes of the guides 40 are made uniform so that the center of gravity of the assembly of the reaction disk 1 and the drive rotor 20 does not deviate from the center line of the shaft 22, for example, the circumference is on a virtual circle concentric with the drive rotor 20. It is desirable to arrange them at equal intervals in the direction.
  • the reaction disk 1 is positioned with respect to the drive disk 21 by the pin hole 1a and the guide 40, and the positional relationship of the reaction disk 1 with respect to the drive disk 21 is determined in the radial direction and the circumferential direction.
  • the fitting tolerance between the pin hole 1a and the guide 40 it is desirable that the diameter difference between the pin hole 1a and the guide 40 is small within the range of clearance fitting.
  • the positions of the guide 40 and the pin hole 1a may be inside in the radial direction of the drive disk 21, but from the viewpoint of suppressing the influence of the diameter difference between the guide 40 and the pin hole 1a on the accuracy of the circumferential position of the reaction cell 11. The outside is desirable.
  • the screw 50 constitutes a fixing mechanism for fixing the reaction disk 1 to the drive rotor 20, and at the same time, also serves as a lift mechanism for the reaction disk 1 (described later) and a holding mechanism for the reaction disk 1 (described later).
  • the screw 50 is arranged at the center of rotation of the drive rotor 20, is inserted from above into a through hole 1b provided vertically through the center of the reaction disk 1, and penetrates the reaction disk 1 to drive the rotor 20. It is screwed into a screw hole extending vertically extending in the center of the shaft 22 of the above.
  • the screw 50 includes a head 51, a shaft portion 52, a lower neck portion 53, and a protrusion portion 54.
  • the shaft portion 52 is a portion in which a thread is carved, and is screwed into a screw hole of the shaft 22 of the drive rotor 20.
  • the diameter of the head 51 is larger than the diameter of the through hole 1b of the reaction disk 1, and the lower surface (seat surface) of the head 51 is the reaction disk 1 with the screw 50 tightened to the drive rotor 20 as shown in FIG. Hold down the top surface of.
  • the lower part of the neck 53 is a portion connecting the head portion 51 and the shaft portion 52, and has a cylindrical shape without threads. A gap is secured between the outer peripheral surface of the lower neck 53 and the inner peripheral surface of the through hole 1b so that the screw 50 and the reaction disk 1 do not rotate in a friendly manner.
  • the protrusion 54 is a ring-shaped portion provided on the lower neck 53, and protrudes from the outer peripheral surface of the lower neck 53.
  • the diameter of the protrusion 54 is larger than the diameter of the through hole 1b of the reaction disk 1.
  • a retaining ring (for example, an E-shaped retaining ring) is adopted as the protrusion 54, and after the screw 50 is passed through the through hole 1b of the reaction disk 1, the lower part of the neck 53 protruding downward of the reaction disk 1.
  • a retaining ring is fixedly attached to the surface, and this is used as a protrusion 54.
  • the screw 50 is related to the reaction disk 1 by the protrusion 54 and the head 51, and the screw 50 cannot be removed from the reaction disk 1 unless the protrusion 54 is removed.
  • the protrusion 54 of the screw 50 is interposed between the facing surfaces of the reaction disk 1 and the shaft 22 under the state where the reaction disk 1 is in contact with the drive disk 21 and the head 51 is in contact with the reaction disk 1 as shown in FIG. It is attached to the lower part of the neck 53 so as to be located away from both of these facing surfaces. Specifically, under the state of FIG. 4, there is a gap G1 between the protrusion 54 and the lower surface 1c of the reaction disk 1, and a distance G2 between the protrusion 54 and the upper surface 22a of the shaft 22. There is a gap.
  • the reaction disk 1 is firmly pressed by the head 51 and is stably fixed to the drive rotor 20. In this way, the screw 50 functions as a fixing mechanism for the reaction disk 1. However, it is not necessary to secure the distances G1 and G2 larger than necessary.
  • the screw 50 also functions as a lift mechanism that translates the reaction disk 1 up and down with respect to the drive rotor 20.
  • a mechanism that converts power into mechanical work and applies a force to the reaction disk 1 to at least one of vertically upward and vertically downward is referred to as a "lift mechanism”.
  • This embodiment is an example of adopting a screw 50 as a lift mechanism and converting human power as power into axial force of the screw as mechanical work.
  • reaction disk 1 is firmly fixed.
  • the elevating orbit of the reaction disk 1 with respect to the drive rotor 20 at that time is vertically guided by the guide 40, and the deflection of the orbit in the radial direction of the reaction disk 1 is suppressed within the range of the fitting tolerance between the guide 40 and the pin hole 1a.
  • the screw 50 when the reaction disk 1 is raised with respect to the drive rotor 20 by loosening the screw 50, if the screw thread of the shaft portion 52 of the screw 50 is engaged with the screw hole of the shaft 22, the screw 50 When the operation is stopped, the reaction disk 1 can be held in a state of being supported by the protrusion 54. In this way, the screw 50 also functions as a holding mechanism for holding the reaction disk 1 in a state of being lifted up with respect to the drive rotor 20.
  • the length of the guide 40 is the difference in height between the lower end 11c of the reaction cell 11 and the upper end 7a of the in-tank component when the guide distance D2 of the reaction disk 1 by the guide 40 is in contact with the drive disk 21.
  • the distance is set to be D1 or more.
  • the guide distance D2 is a distance at which the reaction disk 1 can rise from the lowest position without swinging in the radial direction, and is in the vertical direction from the mask of the reaction disk 1 at the lowest position (the position in contact with the drive disk 21 in this embodiment). It is equal to the measured distance to the tip of the guide 40.
  • the ascending trajectory of the reaction disk 1 rises until the lower end 11c of the reaction cell 11 rises to the height of the upper end 7a of the stirring mechanism 7 which is a component in the tank. It is always guided vertically by the guide 40. Therefore, the reaction cell 11 is pulled up without interfering with the stirring mechanism 7 arranged close to the inside of the reaction tank 30.
  • the distance D3 (FIG. 4) in which the screw 50 is screwed into the shaft 22 of the drive rotor 20 sets the distance G1 from the state of FIG. 4 until the protrusion 54 contacts the reaction disk 1 as the guide distance D2. It is necessary to set the added distance or more (D3 ⁇ G1 + D2).
  • the distance D3 is equal to the length of the shaft portion 52 of the screw 50. That is, since the reaction disk 1 cannot be disengaged from the guide 40 unless it rises by the distance (G1 + D2) from the state of FIG. 4, the distance (G1 + D2) is used to disengage the reaction disk 1 from the guide 40 by the axial force of the screw 50. The above distance D3 is required.
  • the operation of the screw 50 is stopped when the lower end 11c of the reaction cell 11 rises to the height of the upper end 7a of the stirring mechanism 7, and the reaction disk 1 is shown by the function of the holding mechanism described above. It is held like 7. If the screw 50 is further loosened, the reaction disk 1 can be detached from the drive rotor 20 without the reaction cell 11 interfering with the parts in the tank while the reaction cell 11 is attached.
  • FIG. 8 is a flowchart showing an example of a procedure for exchanging reaction cells in the automatic analyzer according to the first embodiment.
  • FIG. 8 shows the replacement work procedure of the reaction cell 11
  • the light source lamp 8a can also be replaced by the same procedure.
  • the description of the replacement work of the light source lamp 8a can be replaced.
  • FIG. 9 described later.
  • a case where the user replaces the reaction cell 11 will be described as an example, but other persons such as a serviceman of the manufacturer of the automatic analyzer 100 will naturally perform the replacement work in the same procedure. Can be done.
  • the user can easily check whether the predetermined maintenance period (maintenance interval) has passed. Can be confirmed. In that case, when the scheduled replacement date has passed, the user can be notified by an alarm sound or a display that the scheduled replacement date has passed.
  • the predetermined maintenance period maintenance interval
  • the control device 300 When the operation to start the replacement work of the reaction cell 11 is performed, the control device 300 outputs a command to the controller 9 and causes the controller 9 to execute the maintenance preparation operation of the automatic analyzer 100 for the replacement work of the reaction cell 11. ..
  • the outline of the maintenance preparation operation is, for example, each of the following operations. 1. 1. Stopping the circulation of the liquid in the reaction tank 30 2. 2. Stop monitoring and controlling the liquid temperature and level of the reaction tank 30. Degaussing the reaction disk 1 (rotation-free)
  • control device 300 When the operation of starting the replacement work of the light source lamp 8a is performed in step S101, the control device 300 further causes the controller 9 to turn off the light source lamp 8a as a part of the maintenance preparation operation.
  • the user may be notified that the maintenance preparation operation has been completed, but it is not always necessary to notify the user. This is because each operation of the maintenance preparation is completed as soon as the operation of starting the replacement work of the reaction cell 11 is performed.
  • Step S104 After removing the reaction disk 1, the user removes the used reaction cell 11 (segment 11A) from the reaction disk 1 and attaches a new reaction cell 11 (segment 11A) to the reaction disk 1.
  • the replacement work of the light source lamp 8a is also carried out, the operation of starting the replacement work of the light source lamp 8a is also performed in step S101, and the replacement work of the light source lamp 8a is performed together with the reaction cell 11.
  • the control device 300 When the completion of the replacement work of the reaction cell 11 is input, the control device 300 outputs a command to the controller 9 and causes the controller 9 to execute the restoration operation of the automatic analyzer 100 to the state before the replacement work of the reaction cell 11. ..
  • the restoration operation is, for example, each of the following operations. 1. 1. Resuming the circulation of the liquid in the reaction tank 30 2. 2. Resumption of monitoring and control of the liquid temperature and level of the reaction tank 30. Replenishing the reaction tank 30 with liquid (if necessary) 4. Excitation of reaction disk 1 (release of rotation-free)
  • control device 300 When the light source lamp 8a is turned off in step S102, the control device 300 further causes the controller 9 to turn on the light source lamp 8a as part of the restoration operation.
  • step S109 After executing the additional maintenance in step S108 (after executing the restoration operation in step S107 if there is no additional maintenance), the user updates the execution date of the replacement work of the reaction cell 11 on the interface 302 to perform the replacement work. To finish. As a result, the latest replacement date and time of the reaction cell 11 is recorded in the memory of the controller 300 (may be the memory of the controller 9), the next scheduled replacement date of the reaction cell 11 is calculated, and the maintenance deadline management is restarted.
  • FIG. 9 is a flowchart showing another example of the procedure for exchanging reaction cells in the automatic analyzer according to the first embodiment of the present invention.
  • the procedures of steps S101, S102, S104, and S106-S109 of the flowchart shown in the figure are the same as the procedures of the same reference numerals in the flowchart of FIG. 8, and thus the description thereof will be omitted.
  • the flow of FIG. 9 differs from the flow of FIG. 8 only in that the procedure of steps S103 and S105 of FIG. 8 is replaced with the procedure of steps S103'and S105', respectively.
  • the procedure of steps S103'and S105' will be described below.
  • step S103' When the maintenance preparation operation by the automatic analyzer 100 is completed in step S102, the user loosens the screw 50 and lifts the reaction disk 1 until the lower end 11c of the reaction cell 11 reaches the height of about the upper end 7a of the stirring mechanism 7. Stop the operation of the screw 50. As a result, the reaction disk 1 is held in a state where the lower end 11c of the reaction cell 11 is raised to the height of the upper end 7a of the stirring mechanism 7. In this example, the user shifts the procedure to step S104 following this state, and replaces the reaction cell 11 (segment 11A) with the reaction disk 1 lifted up by a predetermined distance without removing the reaction disk 1 from the drive rotor 20. ..
  • step S105 After the replacement of the reaction cell 11 is completed in step S104, the user tightens the screw 50 as it is to lower the reaction disk 1, tightens the screw 50 to the end, firmly fixes the reaction disk 1 to the drive rotor 20, and steps S106. Move the procedure to the work of. In the case of this example, since the reaction disk 1 is not removed from the drive rotor 20, the work of moving the reaction disk 1 to the place where the reaction cell 11 is to be replaced and the work of aligning the reaction disk 1 with the drive rotor 20 do not occur.
  • 10 and 11 are flowcharts showing an example of the procedure for cleaning the reaction vessel in the automatic analyzer according to the first embodiment of the present invention.
  • the user can check whether the predetermined maintenance period (maintenance interval) has passed. Can be confirmed. In that case, when the scheduled cleaning date has passed, the user can be notified by an alarm sound or a display that the scheduled cleaning date has passed.
  • the control device 300 When the operation to start the cleaning work of the reaction tank 30 is performed, the control device 300 outputs a command to the controller 9, and the drainage preparation operation is controlled as the maintenance preparation operation of the automatic analyzer 100 for the cleaning work of the reaction tank 30. Let 9 do it.
  • the drainage preparation operation is the same as the maintenance preparation operation (step S102) at the time of replacement work of the reaction cell 11, and is, for example, the following operation. 1. 1. Stopping the circulation of the liquid in the reaction tank 30 2. 2. Stop monitoring and controlling the liquid temperature and level of the reaction tank 30. Degaussing the reaction disk 1 (rotation-free) 4. Turn off the light source lamp 8a
  • the operation of turning off the excitation of the reaction disk 1 may be executed after the drainage of the reaction tank 30 is completed (after step S203).
  • the controller 9 commands and opens the drainage valve (solenoid valve) provided in the drainage pipe of the reaction tank 30, and discharges the liquid from the reaction tank 30.
  • a signal is output from the controller 9 to the control device 300, and the control device 300 notifies the user of the completion of drainage by an alarm sound or a monitor display.
  • the opening time of the drain valve has reached the set value
  • the detected flow rate of the flow meter provided in the drain pipe has become less than a certain value
  • the detected liquid level of the liquid level meter provided in the reaction tank 30 has a constant value. It is possible to make the controller 9 recognize the completion of drainage due to the fact that the amount is less than the above.
  • Step S205 After confirming the notification of the completion of drainage, the user loosens the screw 50 and removes the reaction disk 1 with the reaction cell 11 attached from the drive rotor 20. This operation is the same as step S103 in FIG.
  • Step S206 After removing the reaction disk 1, the user cleans the reaction tank 30.
  • the operation of starting the reaction cell 11 replacement work and the light source lamp 8a replacement work is also performed in step S201, and the reaction tank 30 is used. Along with cleaning, the reaction cell 11 and the light source lamp 8a are replaced.
  • Step S207 After cleaning the reaction tank 30, the user attaches the reaction disk 1 to which the reaction cell 11 is attached to the drive rotor 20. This operation is the same as step S105 in FIG.
  • step S209 When the completion of the cleaning work of the reaction tank 30 is input, the control device 300 outputs a command to the controller 9, and the operation of restoring the automatic analyzer 100 to the state before the cleaning work of the reaction tank 30 is stepwise to the controller 9. To execute.
  • step S209 for example, the following operations are simultaneously executed as restoration operations. 1. 1. Excitation of reaction disk 1 (release of rotation-free) 2. 2. Supply of liquid to reaction vessel 30 3. Addition of antibacterial agents and detergents to the reaction vessel 30 (if necessary)
  • the work of turning on the excitation of the reaction disk 1 may be executed after the liquid is supplied to the reaction tank 30 (step S210).
  • step S210 Once the liquid is supplied to the reaction vessel 30, the controller 9 performs the rest of the restoration operation of the automatic analyzer 100.
  • step S210 for example, the following operations are simultaneously executed as the remaining restoration operations. 1. 1. Resuming the circulation of the liquid in the reaction tank 30 2. 2. Resumption of monitoring and control of the liquid temperature and level of the reaction tank 30. Lighting of light source lamp 8a
  • step S212 After executing the additional maintenance in step S211 (after executing the restoration operation in step S211 if there is no additional maintenance), the user updates the execution date of the cleaning work of the reaction tank 30 on the interface 302 to perform the cleaning work. To finish. As a result, the latest cleaning date and time of the reaction tank 30 is recorded in the memory of the controller 300 (may be the memory of the controller 9), the next scheduled cleaning date of the reaction tank 30 is calculated, and the maintenance deadline management is restarted.
  • the reaction disk 1 when the reaction disk 1 is moved up and down with respect to the drive rotor 20, the reaction disk 1 is guided by the guide 40 and moves vertically in parallel. As a result, it is possible to suppress the radial orbital deviation of the reaction disk 1 when moving up and down, and when the reaction disk 1 is attached or detached with the reaction cell 11 attached, the inner wall of the reaction tank 30 or the inside of the reaction tank 30 is used. It is possible to suppress the interference of the reaction cell 11 with the parts in the tank.
  • reaction disk 1 can be guided until the lower end 11c of the reaction cell 11 exceeds the liquid level of the reaction tank 30, the reaction disk 1 is temporarily held in a state where the reaction cell 11 is completely pulled up from the liquid, and the reaction is carried out.
  • the droplets adhering to the outer wall of the cell 11 can be dropped into the reaction tank 30.
  • droplets adhering to the outer wall of the reaction cell 11 can be prevented from dripping and interfering with the electrical components of the automatic analyzer 100. Therefore, the reaction disk 1 can be detached and maintained efficiently with the reaction cell 11 attached, and the reaction cell 11 and peripheral parts can be protected from damage when the reaction disk 1 is attached and detached.
  • the vertical movement of the reaction disk 1 is smoothly guided by the guide 40, it is not necessary to lift the reaction disk 1 while moving it in small steps in the horizontal direction when removing the reaction disk 1. Therefore, the work load on the user is reduced, and the reaction disk 1 is not shaken and hit by an obstacle.
  • the guide distance D2 of the reaction disk 1 by the guide 40 is the difference in height between the lower end 11c of the reaction cell 11 and the upper end 7a of the in-tank component (stirring device 7 in the example of FIG. 4).
  • the distance is set to D1 or more. Therefore, as long as the reaction cell 11 is in a positional relationship of overlapping the components in the tank and the reaction disk 1 in the radial direction (when the lower end 11c is lower than the upper end 7a), the radial movement of the reaction disk 1 is always constrained by the guide 40. .. Therefore, when the reaction disk 1 is attached and detached with the reaction cell 11 attached, the interference between the reaction cell 11 and the parts in the tank can be mechanically suppressed.
  • the reaction disk 1 Since the distance D3 (FIG. 4) in which the screw 50 is screwed into the drive rotor 20 is set longer than the guide distance D2 (same as above), the reaction disk 1 is lifted up to a height away from the guide 40. Can be held. During this period, the reaction disk 1 is maintained in an independent state, and it is not necessary for the user or the like to support the reaction disk 1 by hand. As a result, even if the reaction disk 1 is not removed from the drive rotor 20, the reaction cell 11 can be lifted to a height that does not interfere with the parts in the tank as described with reference to FIG. 9, and the reaction cell 11 can be replaced. The work of moving the removed reaction disk 1 and the work of alignment at the time of reassembly can be omitted, and the work of replacing the reaction cell 11 can be carried out more efficiently.
  • the screw 50 functions as a lift mechanism, and the axial force of the screw 50 is applied to the reaction disk 1 so that the reaction disk 1 can be translated up and down with respect to the drive rotor 20.
  • a force can be applied vertically to the reaction disk 1, the force is dissipated in the horizontal direction much less than when the reaction disk 1 is manually raised and lowered, and the ascending / descending trajectory of the reaction disk 1 provides higher linearity. You can have it.
  • the fixing mechanism and the lift mechanism of the reaction disk 1 can be shared by the screw 50.
  • the screw is an element that is generally used for positioning in machines, and can also be used as a holding mechanism.
  • the fixing mechanism, the lifting mechanism, and the holding mechanism of the reaction disk 1 can be constructed extremely simply by using one screw 50. Further, since the screw 50 is located at the center of the reaction disk 1, the head 51 of the screw 50 replaces the grip when the screw 50 is removed from the drive rotor 20 and the reaction disk 1 with the reaction cell 11 attached is carried. It also becomes. Since there is only one screw 50, the work of tightening and loosening the screws is also light.
  • FIGS. 12 and 13 are cross-sectional views of the reaction disk provided in the automatic analyzer according to the second embodiment of the present invention and its peripheral parts cut along a plane including the rotation center line of the reaction disk, respectively.
  • FIG. 12 is a configuration example of the second embodiment
  • FIG. 13 is another configuration example of the second embodiment.
  • the same or corresponding elements as those in the first embodiment are designated by the same reference numerals as those in the above-mentioned drawings, and the description thereof will be omitted.
  • the difference between the present embodiment and the first embodiment is that the first embodiment has only one screw 50, whereas the present embodiment has a plurality of screws 50.
  • the structure of the screw 50 itself is the same as that of the first embodiment, and includes the head 51, the shaft portion 52, the lower neck portion 53, and the protrusion portion 54.
  • the screw holes corresponding to the plurality of screws 50 are arranged off the center of the shaft 22 of the drive rotor 20, and all of them are provided in the drive disk 21.
  • a through hole 1b through which each screw 50 is passed is arranged in a portion of the reaction disk 1 facing the drive disk 21.
  • the number of screws 50 may be a plurality, but from the viewpoint of stability of the fixed structure, three or more screws are preferable so that a virtual plane can be defined at the arrangement point of each screw 50.
  • the number of screws 50 increases, the labor required for operating the screws 50 when attaching / detaching the reaction disk 1 increases. Therefore, considering this point as well, it is desirable that the number of screws 50 is three or slightly larger.
  • the plurality of screws 50 are arranged at equal intervals in the circumferential direction, for example, on a virtual circle concentric with the drive rotor 20 so that the center of gravity of the assembly of the reaction disk 1 and the drive rotor 20 does not deviate from the center line of the shaft 22. There is. If three screws 50 of the same weight are used, the layout is 120 degree pitch.
  • the positional relationship with the guide 40 is not particularly limited, but as described in the first embodiment, since the guide 40 is arranged away from the center line of the shaft 22 from the viewpoint of the positioning accuracy of the reaction disk 1, FIGS. 12 and 12 and FIGS. In the example of 13, the screw 50 is arranged closer to the shaft 22 than the guide 40.
  • the screw 50 is also far from the shaft 22, for example, the guide 40 and the screw 50 are concentric with the drive rotor 20. It can also be configured to be arranged on a circle.
  • the recess (seat) facing the drive disk 21 is formed in the penetrating portion of the through hole 1b in the reaction disk 1. (Curly) is provided. This is to secure a gap for the protrusion 54 to move between the protrusion 54 and the reaction disk 1 as in the first embodiment.
  • the recesses are, for example, circular when viewed from the drive disk 21 side, and there are a plurality of recesses corresponding to the screws 50.
  • FIG. 12 illustrates a configuration in which the plate thickness of the portion of the reaction disk 1 where the recess is provided is thinner than the plate thickness of the surrounding portion, but in FIG.
  • the upper surface of the reaction disk 1 is turned up corresponding to the recess.
  • the excitement of the configuration is illustrated.
  • the example of FIG. 13 is advantageous from the viewpoint of suppressing the decrease in strength of the reaction disk 1 at the portion where the recess is provided, and the example of FIG. 12 is advantageous from the viewpoint of reducing the weight of the reaction disk 1.
  • the present embodiment has the same configuration as the first embodiment, and the effects obtained in the first embodiment by the common configuration can be similarly obtained in the present embodiment. Further, since there are a plurality of screws 50 and they are separated from the center of rotation by a certain distance, there is an advantage that the stability of the fixed structure of the reaction disk 1 is increased.
  • the shaft 22 of the drive rotor 20 can be penetrated through the center of the reaction disk 1, so that the user can expose a part of the drive rotor 20 from the hole in the center of the reaction disk 1. .. Therefore, if the alignment mark is attached to the upper end surfaces of the reaction disk 1 and the shaft 22 as described above, the alignment work of the guide 40 and the pin hole 1a when setting the reaction disk 1 on the drive rotor 20 can be performed. It can be made more efficient. However, this is an effect accompanying one configuration example of the reaction disk 1 as shown in FIGS. 12 and 13, and in the present embodiment, the upper part of the shaft 22 is covered with the reaction disk 1 as in the first embodiment. The essential effect is not lost even if it is configured.
  • FIG. 14 is a cross-sectional view of the reaction disk provided in the automatic analyzer according to the third embodiment of the present invention and its peripheral parts cut along a plane including the rotation center line of the reaction disk, and is a cross-sectional view of FIG. 4 of the first embodiment.
  • FIG. 15 is a diagram showing a state in which the reaction disk is lifted up from the state shown in FIG. 14, and corresponds to FIG. 7 of the first embodiment.
  • the same or corresponding elements as those in the first embodiment or the second embodiment are designated by the same reference numerals as those in the existing drawings, and the description thereof will be omitted.
  • the difference between this embodiment and the first embodiment is that in the first embodiment, the lift mechanism and the like are configured by the screws 50, whereas in the present embodiment, the fixing mechanism, the lift mechanism and the holding mechanism are the spring 55. It is a point that is configured to include a screw 56. In the present embodiment, the screws 50 adopted in the first embodiment and the second embodiment are omitted in the present embodiment.
  • the spring 55 is a spring that expands and contracts in the vertical direction (coil spring in the present embodiment), is interposed between the reaction disk 1 and the drive rotor 20 (drive disk 21 in the present embodiment), and is formed by the reaction disk 1 and the drive rotor 20. It is sandwiched from above and below and compressed. As a result, the restoring force of the spring 55 acts as a force to push up the reaction disk 1 with respect to the drive rotor 20.
  • the end of only one of the upper and lower springs 55 is fixed to the lower surface of the reaction disk 1 or the upper surface of the drive rotor 20.
  • a cylindrical spring guide 57 for guiding the expansion and contraction of the spring 55 is provided, and the outer periphery of the spring 55 is covered with the spring guide 57 in the fully contracted posture of FIG.
  • the end of only one of the upper and lower spring guides 57 is fixed to the lower surface of the reaction disk 1 or the upper surface of the drive rotor 20.
  • the configuration in which the spring guide 57 is fixed to the drive rotor 20 is exemplified, but the configuration in which the spring guide 57 is provided on the reaction disk 1 may be used.
  • the number of springs 55 installed can be singular or plural.
  • the number of springs 55 is singular, for example, a coil spring having an inner diameter larger than the outer diameter of the shaft 22 is adopted, and the spring 55 is covered on the shaft 22 from above and sandwiched between the drive disk 21 and the reaction disk 1.
  • the spring 55 is arranged concentrically with the reaction disk 1 in this way, the vector of the pushing force acting on the reaction disk 1 due to the restoring force of the spring 55 can be vertically upward.
  • the plurality of springs 55 have the same size, shape, and restoring force, and are arranged at equal intervals in the circumferential direction on a virtual circle concentric with the drive rotor 20. This is to make the vector of the pushing force acting on the reaction disk 1 by the restoring force of the spring 55 vertically upward.
  • 14 and 15 show an example in which a plurality of springs 55 are used.
  • the screw 56 is screwed vertically downward into the drive rotor 20 to hold the reaction disk 1 from above.
  • the screw 56 includes a head portion 56a and a shaft portion 56b, and has an element that restrains the screw 56 with respect to the reaction disk 1 (an element corresponding to the protrusion 54 of the screw 50 of the first embodiment). No.
  • the lower neck may or may not be present.
  • the shaft portion 56b is located on the center line of the shaft 22 and is screwed into the shaft 22 from the upper end surface.
  • the head 56a is formed in a cover shape that covers the upper surface and the outer peripheral surface of the handle 1d of the reaction disk 1, but the shape can be changed if the reaction disk 1 can be pressed by interfering with a part of the upper surface of the reaction disk 1.
  • the reaction disk 1 has the same shape as that of the third embodiment in FIGS. 14 and 15, it may have a shape that covers the upper part of the shaft 22 of the drive rotor 20 as in the first embodiment or the second embodiment. ..
  • the distance D4 at which the spring 55 extends is the above-mentioned difference distance D1 or more.
  • the distance D5 (FIG. 15) from the base end (upper surface of the drive disk 21) of the guide 40 to the tip end (upper end) of the guide 40 is preferably the sum of the distance D6 (FIG. 14) and the distance D4 or more. (D5 ⁇ D4 + D6).
  • the distance D6 is an interval between the facing surfaces of the reaction disk 1 and the drive disk 21 in a state where the reaction disk 1 is fixed to the drive disk 21 (FIG. 14).
  • the reaction disk 1 when the screw 56 is tightened in the present embodiment, the reaction disk 1 is pressed by the head 56a and descends against the restoring force of the spring 55. By tightening the screw 56 to the end, the reaction disk 1 can be fixed to the drive rotor 20 as shown in FIG. Further, when the screw 56 is loosened, the reaction disk 1 is raised by the restoring force of the spring 55 by the amount that the screw 56 is loosened. By loosening the screw 56 by a certain amount or more, the reaction disk 1 is lifted to a height disengaged from the guide 40 as shown in FIG.
  • the axial force of the screw 50 was used for the force for lifting the reaction disk 1, and the own weight of the reaction disk 1 was used for the force for lowering the reaction disk 1.
  • the axial force of the screw 56 is used for the force for lowering the reaction disk 1
  • the restoring force of the spring 55 is used for the force for lifting the reaction disk 1.
  • the reaction disk 1 is moved up and down by the axial force of the screw 56 and the restoring force of the spring 55, and the trajectory of the vertical movement of the reaction disk 1 is the same as in the first and second embodiments. Can be guided vertically by the guide 40. Therefore, the reaction disk 1 can be detached and maintained efficiently with the reaction cell 11 attached, and the reaction cell 11 and peripheral parts can be protected when the reaction disk 1 is attached and detached.
  • present embodiment has the same configuration as the first embodiment or the second embodiment except for the configuration described above, and the effects obtained in the first embodiment or the second embodiment by the common configuration are the present embodiment. The same can be obtained in the form.
  • FIG. 16 is a cross-sectional view of the reaction disk provided in the automatic analyzer according to the fourth embodiment of the present invention and its peripheral parts cut along a plane including the rotation center line of the reaction disk, and is a cross-sectional view of FIG. 4 of the first embodiment. , FIG. 12 and FIG. 13 of the second embodiment, and FIG. 14 of the third embodiment.
  • FIG. 17 is a diagram showing a state in which the reaction disk is lifted up from the state shown in FIG. 16, and corresponds to FIG. 7 of the first embodiment and FIG. 15 of the third embodiment.
  • FIG. 18 is a partial arrow view taken by arrow XVIII in FIG.
  • FIGS. 16-18 the same or corresponding elements as those in the first to third embodiments are designated by the same reference numerals as those in the existing drawings, and the description thereof will be omitted.
  • the difference between the present embodiment and the first to third embodiments is that the reaction disk 1 is connected to the drive disk 21 via the telescopic mechanism 58.
  • the telescopic mechanism 58 is interposed between the reaction disk 1 and the drive disk 21, is configured to include a plurality of cylinders 58a-58c, and expands and contracts in the vertical direction.
  • the central cylinder 58b is housed in the outer cylinder 58a
  • the inner cylinder 58c is housed in the cylinder 58b so as to be accessible.
  • the outer cylinder 58a is fixed to the upper surface of the drive rotor 20, and the inner cylinder 58c is fixed to the reaction disk 1.
  • FIG. 17 illustrates a state in which the reaction disk 1 is lifted up to the upper limit, and is configured so that the reaction disk 1 is not lifted from the state shown in the figure by being restrained by the telescopic mechanism 58 unless the telescopic mechanism 58 is removed. ..
  • the reaction disk 1 has the same shape as that of the third embodiment.
  • the shaft 22 projects only downward from the drive disk 21, and the upper end surface of the shaft 22 is flush with the upper surface of the drive disk 21. As a result, a space is secured inside the central cylindrical portion of the reaction disk 1.
  • FIG. 16 and 17 illustrate a configuration in which the actuator 59 is used as a lift mechanism for pushing up the reaction disk 1 with respect to the drive rotor 20.
  • the lift mechanism of the reaction disk 1 utilizing the axial force of the screw and the restoring force of the spring is not adopted.
  • the actuator 59 can be installed in the space reserved inside the central cylindrical portion of the reaction disk 1.
  • a cylinder may be used for the actuator 59, but in this embodiment, a configuration using an electric motor is exemplified.
  • an electric motor for example, the ball screw passed through the nut attached to the reaction disk 1 may be rotated by the actuator 59 fixed to the drive rotor 20, but in the present embodiment, the rack and pinion is driven by the electric motor.
  • the configuration to be used is illustrated.
  • a rack and pinion is a type of gear that converts rotational motion into linear motion, and is a combination of a rod-shaped member and a geared rack with a pinion.
  • the rack is mounted vertically on the inner wall of the central cylindrical portion of the reaction disk 1, and the pinion attached to the output shaft of the electric motor as the actuator 59 is attached to the teeth of the rack. It is in mesh.
  • the actuator 59 is fixed to the drive disk 21 via a bracket.
  • the actuator 59 When the actuator 59 is driven to rotate the pinion in the normal direction, the rack rises with respect to the pinion and the reaction disk 1 rises with respect to the drive rotor 20. On the contrary, when the pinion is reversed by the actuator 59, the rack is lowered with respect to the pinion and the reaction disk 1 is lowered with respect to the drive rotor 20.
  • the actuator 59 is controlled by the controller 9. Since the actuator 59 has a braking force of the output shaft, it functions not only as a lift mechanism but also as a fixing mechanism and a holding mechanism of the reaction disk 1.
  • the actuator 59 may be omitted and the reaction disk 1 may be lifted by holding the handle 1d. Even if the actuator 59 is omitted, the elevating trajectory of the reaction disk 1 is guided by the guide 40, so that interference between the reaction cell 11 and peripheral parts can be suitably suppressed. If the actuator 59 is adopted, it is not particularly necessary, but when the reaction disk 1 is lifted by holding the handle 1d in this way, the handle 1d is covered so that the reaction disk 1 is not accidentally lifted except for maintenance. It is preferable to provide the lid 1e.
  • the lid 1e may be configured to cover the handle 1d, but it is desirable that the lid 1e does not interact with the reaction disk 1 and the reaction disk 1 does not lift up with respect to the lid 1e even if the lid 1e is lifted (FIG. 16). ..
  • the distance D7 at which the telescopic mechanism 58 extends is the above-mentioned difference distance D1 or more.
  • the distance D5 (FIG. 17) from the base end (upper surface of the drive disk 21) of the guide 40 to the tip end (upper end) of the guide 40 is the sum of the distance D8 (FIG. 16) and the distance D7 (FIG. 17) or more. It is desirable to do (D5 ⁇ D7 + D8).
  • the distance D8 is an interval between the facing surfaces of the reaction disk 1 and the drive disk 21 in a state where the reaction disk 1 is fixed to the drive disk 21 (FIG. 16).
  • the telescopic mechanism 58 is provided with a locking mechanism using a slit 58s and a protrusion 58p as shown in FIG.
  • the cylinders constituting the telescopic mechanism 58 one of the two cylinders engaged with each other is provided with a slit 58s, and the other is provided with a protrusion 58p inserted into the slit 58s.
  • the slit 58s has an L-shape in a portion extending in the vertical direction and a portion extending in the horizontal direction from the upper end thereof, and is formed in the cylinders 58a and 58b, respectively, in the present embodiment.
  • the protrusion 58p is, for example, a short columnar pin, and in the present embodiment, the protrusion 58p protrudes outward in the radial direction from the outer peripheral surfaces of the cylinders 58b and 58c.
  • the protrusion 58p of the cylinder 58c is inserted into the slit 58s of the cylinder 58b, and the protrusion 58p of the cylinder 58b is inserted into the slit 58s of the cylinder 58a.
  • the protrusion 58p moves in an L shape inside the slit 58s and moves to the horizontal portion of the slit 58s as shown by the two-dot chain arrow in FIG. As a result, the expansion and contraction of the telescopic mechanism 58 is locked, and the reaction disk 1 is stably held in a lifted state.
  • the present embodiment may have the same configuration as the first embodiment, the second embodiment, or the third embodiment.
  • FIG. 19 is a flowchart showing an example of a procedure for exchanging reaction cells in the automatic analyzer according to the fourth embodiment of the present invention.
  • the procedures of steps S101, S102, S104, and S106-S109 of the flowchart shown in the figure are the same as the procedures of the same reference numerals in the flowcharts of FIGS. 8 and 9 described in the first embodiment, and thus the description thereof is omitted. do.
  • the procedures of steps S105 "and S106 corresponding to steps S105 and S106 in the first embodiment are reversed.
  • the flow of FIG. 19 is, for example, the flow of FIG.
  • the only difference is that the procedures of steps S103 and S105 in FIG. 8 are replaced with the procedures of steps S103 "and S105", respectively, and steps S103s are added between steps S103 "and S104".
  • the procedure of steps S103 ", S103s, S105" will be described below.
  • Step S103 When the maintenance preparation operation in step S102 is completed, the user operates the reaction disk 1 from the user interface 302 (FIG. 1). When the reaction disk 1 is raised, the control device 300 outputs a command to the controller 9 and drives the actuator 59 to raise the reaction disk 1.
  • a signal is output from the controller 9 to the control device 300, and the control device 300 notifies the user of the completion of lift-up of the reaction disk 1 by an alarm sound or a monitor display.
  • the fact that the reaction disk 1 has risen to a predetermined height can be determined from, for example, the rotation speed and the driving time of the actuator 59.
  • the rotation speed of the actuator is a known constant value, and the drive time can be measured by a timer provided in the controller 9. It is also possible to calculate the ascending distance of the reaction disk 1 from the number of rotations (meaning the number of rotations) of the output shaft of the actuator 59.
  • a limit switch is installed in the telescopic mechanism 58, and it is configured to detect that the telescopic mechanism 58 extends to a predetermined length and the reaction disk 1 reaches a predetermined height when a signal is input from the limit switch. You can also do it.
  • the user moves to step S104 to replace the reaction cell 11.
  • the reaction disk 1 cannot be removed from the drive rotor 20
  • the reaction cell 11 is replaced without removing the reaction disk 1 from the drive rotor 20.
  • Step S105 After completing the exchange of the reaction cell 11 in step S104, the user inputs the completion of the exchange work of the reaction cell 11 by the user interface 302 (FIG. 1) (step S106).
  • a command is output from the control device 300 to the controller 9 with the input of the completion of the replacement work as a trigger, the actuator 59 is driven, and the reaction disk 1 is lowered (step S105 ").
  • the restoration operation of step S107 is subsequently executed (step S107).
  • the restoration operation is as described in the first embodiment, and the subsequent procedure is the same as that of the first embodiment.
  • the vertical movement of the reaction disk 1 is vertically guided by the guide 40, and the reaction disk 1 can be detached and detached for efficient maintenance with the reaction cell 11 attached, and the reaction disk 1 is attached and detached. At this time, the reaction cell 11 and peripheral parts can be protected. At that time, in the present embodiment, the reaction disk 1 can be raised and lowered by the actuator 59, so that the burden on the user required for the maintenance work can be reduced. Since the drive rotor 20 and the reaction disk 1 are connected by the telescopic mechanism 58, the reaction disk 1 does not unintentionally fall out of the drive rotor 20. In addition, regarding the configuration common to the first to third embodiments, the effects obtained in the first to third embodiments are similarly obtained in the present embodiment.
  • FIG. 20 is a schematic view showing a reaction vessel and peripheral parts thereof provided in the automatic analyzer according to the fifth embodiment of the present invention.
  • the present embodiment relates to controlling the liquid level of the reaction tank 30 at the time of exchanging the reaction cell 11.
  • the water supply pipe P1 connected to the reaction tank 30 is provided with a water supply valve V1
  • the drainage pipe P2 connected to the reaction tank 30 is provided with a drainage valve V2.
  • the water supply valve V1 and the drain valve V2 are, for example, solenoid valves and are controlled to open and close by the controller 9.
  • the height of the lower end 11c of the reaction cell 11 is the liquid stored inside the reaction tank 30 during the analysis operation even when the reaction disk 1 is raised to the highest position within the guide distance D2 (FIG. 4 or the like). It shall not exceed the liquid level of. That is, in the state where the liquid level at the time of the analysis operation is maintained, even if the reaction disk 1 is raised by the guide distance D2, the lower part of the reaction cell 11 does not escape from the state of being immersed in the liquid.
  • the controller 9 controls the drain valve V2 at a predetermined timing, and the liquid level of the reaction tank 30 is raised to the lower end 11c of the reaction cell 11 or a position lower than that, which is the highest in the range of the guide distance D2. It is configured to be lowered.
  • the up arrow in FIG. 20 indicates the rise of the reaction cell 11, and the down arrow indicates the decrease of the liquid level.
  • the liquid level after the decrease is preferably close to the lower end of the reaction cell 11 after the increase, and for example, the upper end of the in-tank component (stirring mechanism 7 in FIG. The liquid is not completely drained.
  • This operation of lowering the liquid level is executed by the controller 9 when a signal instructing the start of maintenance is input from the control device 300, and is executed, for example, in association with the maintenance preparation operation of step S102 (FIGS. 8, 9, 19). ..
  • the amount of decrease in the liquid level is controlled, for example, by the opening time of the drain valve V2 (opening the drain valve V2 for the set time), a liquid level gauge is installed in the reaction tank 30, and the liquid level is detected based on the liquid level.
  • a method of controlling the opening and closing of the drain valve V2 can be applied.
  • the controller 9 controls the water supply valve V1 to raise the liquid level to the height before drainage.
  • This operation of raising the liquid level is executed, for example, in association with the restoration operation of step S107 (FIG. 8, FIG. 9, FIG. 19).
  • the amount of increase in the liquid level is controlled, for example, by the opening time of the water supply valve V1 (the water supply valve V1 is opened only for the set time). A method of controlling the opening and closing of the water supply valve V1 can be applied.
  • the present embodiment may have the same configuration as the first embodiment, the second embodiment, the third embodiment, or the fourth embodiment.
  • the work of pulling up the entire reaction cell 11 from the liquid in the reaction tank 30 and temporarily holding the reaction cell 11 is automatically performed according to the maintenance preparation operation of the automatic analyzer 100 without the need for the user to manually perform the work. be able to. That is, since the draining step of the outer wall of the reaction cell 11 is completed at the stage where the user removes the reaction disk 1 from the drive rotor 20, the droplets dripping from the outer wall of the reaction cell 11 during the removal work of the reaction disk 1 are electrical components. It is possible to suppress the interference with the device more rationally. As a result, it is possible to reduce the psychological burden on the user during maintenance work and the burden on the work of wiping off scattered droplets.
  • the actuator can be used as the elevating drive device as in the fourth embodiment instead of the screw or the spring. That is, the actuator can be used as a lift mechanism, a fixing mechanism, and a holding mechanism even in a configuration in which the reaction disk 1 is not connected to the drive rotor 20 by the telescopic mechanism 58.
  • the lift mechanism of the reaction disk 1 utilizing the axial force of the screw and the restoring force of the spring can be adopted instead of the actuator 59.
  • the reaction disk 1 can be lifted and lowered by hand without using screws, springs, or actuators.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
PCT/JP2021/004440 2020-06-08 2021-02-05 自動分析装置 Ceased WO2021250940A1 (ja)

Priority Applications (4)

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EP21820090.5A EP4163640A4 (en) 2020-06-08 2021-02-05 AUTOMATIC ANALYSIS DEVICE
US18/007,598 US20230258674A1 (en) 2020-06-08 2021-02-05 Automatic Analysis Apparatus
CN202180038217.XA CN115769082A (zh) 2020-06-08 2021-02-05 自动分析装置
JP2022530022A JP7447261B2 (ja) 2020-06-08 2021-02-05 自動分析装置

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JP2020-099591 2020-06-08

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EP4163640A4 (en) 2024-06-12
JPWO2021250940A1 (https=) 2021-12-16
JP7447261B2 (ja) 2024-03-11
CN115769082A (zh) 2023-03-07
US20230258674A1 (en) 2023-08-17
EP4163640A1 (en) 2023-04-12

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