WO2021240600A1 - Dispositif de mesure de glycémie - Google Patents

Dispositif de mesure de glycémie Download PDF

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Publication number
WO2021240600A1
WO2021240600A1 PCT/JP2020/020545 JP2020020545W WO2021240600A1 WO 2021240600 A1 WO2021240600 A1 WO 2021240600A1 JP 2020020545 W JP2020020545 W JP 2020020545W WO 2021240600 A1 WO2021240600 A1 WO 2021240600A1
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Prior art keywords
infrared
blood glucose
measuring device
glucose level
level measuring
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PCT/JP2020/020545
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English (en)
Japanese (ja)
Inventor
貴士 横山
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日本碍子株式会社
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Priority to PCT/JP2020/020545 priority Critical patent/WO2021240600A1/fr
Publication of WO2021240600A1 publication Critical patent/WO2021240600A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters

Definitions

  • the present invention relates to a blood glucose level measuring device.
  • insulin injection is given. If insulin injections are given, blood glucose levels are measured. Blood glucose measurement is performed to understand the timing of insulin injection and the effect of treatment.
  • the needle When the blood glucose level is measured, the needle is pierced into the human body until the tip of the needle reaches the inside of the blood vessel, and blood is collected. In addition, the collected blood is brought into contact with the sample chip. Consumables such as needles and sample chips are discarded each time the blood glucose level is measured.
  • the act of sticking the needle into the human body until the tip of the needle reaches the inside of the blood vessel is invasive. For this reason, the practice carries the risk of suffering from pain and infection.
  • disposing of consumables such as needles and sample chips every time the blood glucose level is measured causes a problem that a large cost must be spent on consumables such as needles and sample chips. The cost of consumables such as needles and sample chips in one year reaches about 200,000 yen in Japan.
  • the blood glucose level can be measured non-invasively.
  • infrared rays are applied to the human body.
  • the intensity of infrared rays coming from the human body is detected while the infrared rays are radiated to the human body.
  • the glucose concentration in the interstitial fluid is calculated from the amount of infrared rays absorbed by the glucose in the interstitial fluid. If blood glucose measurements are made non-invasively, the risk of suffering from pain and infection can be eliminated. In addition, the cost spent on consumables can be eliminated. Therefore, when the blood glucose level can be measured non-invasively, the blood glucose level can be measured for the prevention of diabetes or the improvement of the blood glucose level.
  • Patent Document 1 discloses a glucose meter.
  • a laser beam of mid-infrared light is applied to the biological epithelium of the subject. Further, the diffusely reflected light of the laser light is detected by the photodetector. In addition, the glucose concentration in the interstitial fluid is measured from the absorption by glucose.
  • the light source that oscillates the laser beam includes a Q switch Nd: YAG laser or the like and an optical parametric oscillator (OPO) (paragraphs 0021-0023).
  • Patent Document 2 discloses a measuring device.
  • the infrared light output from the Fourier transform infrared spectroscopy (FTIR) device undergoes attenuation corresponding to the infrared light absorption spectrum of the sample. Also, the attenuated light is detected by the detector.
  • the blood glucose level is measured using the absorption spectrum of glucose (paragraph 0022-0023).
  • a blood glucose measuring device that measures blood glucose in a non-invasive manner has problems such as large size, high cost, difficulty in increasing the output of a light source, and difficulty in improving the accuracy of measurement. ..
  • the blood glucose meter disclosed in Patent Document 1 since the energy efficiency of the Q-switch Nd: YAG laser or the like is low, the size of the power supply that supplies power to the Q-switch Nd: YAG laser or the like becomes large, and the Q-switch Nd : A cooling system for cooling the YAG laser or the like is required, and a cooling mechanism is required. Therefore, the blood glucose meter has problems such as large size, high cost, and difficulty in increasing the output of the light source.
  • the size of the FTIR device is large, the energy efficiency of the FTIR device is low, and the cost of the FTIR device is high. Therefore, the measuring device has problems such as large size, high cost, and difficulty in increasing the output of the light source.
  • the present invention has been made in view of these problems.
  • the present invention reduces the size of the blood glucose measuring device that measures the blood glucose level in a non-invasive manner, lowers the cost of the blood glucose measuring device, and increases the output of the light source provided in the blood glucose measuring device. The purpose.
  • the present invention relates to a blood glucose level measuring device.
  • the blood glucose measuring device is equipped with an infrared radiator and a detector.
  • the infrared radiator has a radiating surface.
  • the infrared radiator comprises a metamaterial.
  • the infrared radiator radiates infrared rays from the radiation surface.
  • the peak wavelength of infrared rays is a wavelength according to the structure of the metamaterial.
  • the detector detects the amount that reflects the amount of infrared rays absorbed by glucose in the living body.
  • the amount of infrared rays absorbed by glucose is specified by using infrared rays radiated by an infrared radiator that does not require a cooling system and has high energy efficiency.
  • the size of the blood glucose measuring device that measures the blood glucose level in a non-invasive manner can be reduced.
  • the cost of the blood glucose level measuring device can be reduced.
  • the output of the light source provided in the blood glucose level measuring device can be increased.
  • FIG. 1 It is sectional drawing which shows schematically the infrared radiator provided in the blood glucose level measuring apparatus of 5th Embodiment. It is a top view schematically illustrating the infrared radiator provided in the blood glucose level measuring apparatus of 5th Embodiment. It is a perspective view which shows another example of the heat radiation plate provided in the blood glucose level measuring apparatus from 1st Embodiment to 5th Embodiment schematically. It is a perspective view which shows another example of the heat radiation plate provided in the blood glucose level measuring apparatus from 1st Embodiment to 5th Embodiment schematically. It is a perspective view which shows another example of the heat radiation plate provided in the blood glucose level measuring apparatus from 1st Embodiment to 5th Embodiment schematically.
  • FIG. 1 is a cross-sectional view schematically showing the blood glucose level measuring device of the first embodiment.
  • FIG. 2 is a cross-sectional view schematically illustrating an infrared radiator provided in the blood glucose level measuring device of the first embodiment.
  • FIG. 3 is a graph showing an example of an absorption spectrum of glucose and an infrared radiation intensity spectrum thermally radiated by an infrared radiator provided in the blood glucose level measuring device of the first embodiment.
  • the vertical axis represents the absorbance and the radiant intensity.
  • the wave number is taken on the horizontal axis.
  • the blood glucose level measuring device 1 of the first embodiment shown in FIG. 1 is a wavelength-independent blood glucose level measuring device in which each of the infrared rays IR1 and IR2 irradiated to the living body LB has only one peak wavelength.
  • the blood glucose level measuring device 1 includes an infrared radiator 11, an infrared radiator 12, an optical system 21, an optical system 22, a shutter 31, a shutter 32, a detector 41, a controller 51, and a calculator. 61 is provided.
  • the infrared radiators 11 and 12 radiate infrared rays IR1 and IR2, respectively.
  • the infrared IR1 and IR2 have peak wavelengths ⁇ 1 and ⁇ 2, respectively.
  • the peak wavelengths ⁇ 1 and ⁇ 2 are different from each other. Therefore, the infrared IR1 and IR2 have different peak wavelengths from each other.
  • the optical systems 21 and 22 collect the heat-radiated infrared rays IR1 and IR2, respectively.
  • the shutters 31 and 32 open and close the optical paths of the heat-radiated infrared rays IR1 and IR2, respectively.
  • the detector 41 detects an amount D that reflects the amount of infrared rays IR1 and IR2 absorbed by glucose in the living body LB.
  • the detector 41 is an infrared detector.
  • the detected amount D is the intensity of the incoming infrared AIR that arrives from the living body LB while the infrared rays IR1 and IR2 are irradiated on the living body LB.
  • the infrared detector is a photodiode.
  • the infrared detector may be an infrared detector other than the photodiode.
  • the living body LB is a human body.
  • the living body LB may be a living body other than the human body.
  • the infrared rays IR1 and IR2 are irradiated to, for example, a finger or an ear. Further, the detector 41 detects the intensity of the incoming infrared AIR coming from, for example, a finger or an ear.
  • the calculator 61 calculates the blood glucose level from the detected amount D.
  • the controller 51 controls the infrared radiators 11 and 12 to radiate the infrared rays IR1 and IR2 to the infrared radiators 11 and 12, respectively. Further, the controller 51 controls the shutters 31 and 32 to open and close the optical paths of the infrared IR1 and IR2 to the shutters 31 and 32, respectively.
  • the infrared radiators 11 and 12 are two infrared radiators. Further, infrared rays IR1 and IR2 are two infrared rays. Further, the optical systems 21 and 22 are two optical systems. Further, the shutters 31 and 32 are two shutters. However, the number of infrared radiators, the number of infrared rays, the number of optical systems and the number of shutters may be increased or decreased.
  • the peak wavelength ⁇ 1 of the infrared IR1 is the wavelength at which the absorbance of glucose is minimized. Infrared IR1 is used for calibration. The peak wavelength ⁇ 1 may be a wavelength other than the wavelength at which the absorbance of glucose is minimized. Further, the peak wavelength ⁇ 2 of the infrared IR2 is a wavelength at which the absorbance of glucose is maximized. Infrared IR2 is used for measurement. The peak wavelength ⁇ 2 may be a wavelength other than the wavelength at which the absorbance of glucose is maximized.
  • the controller 51 causes the shutters 31 and 32 to close the optical paths of the infrared IR1 and IR2.
  • the controller 51 starts the infrared radiators 11 and 12 to thermally radiate the infrared rays IR1 and IR2 after the optical paths of the infrared IR1 and IR2 are closed.
  • the controller 51 causes the shutter 31 to open the optical path of the infrared IR1 after the infrared IR1 and IR2 are stabilized. As a result, the infrared IR1 is irradiated to the living body LB. At this time, the infrared IR1 is focused on the surface of the living body LB by the optical system 21.
  • the controller 51 causes the shutter 31 to close the optical path of the infrared IR1 when a set time has elapsed since the optical path of the infrared IR1 was opened. As a result, the infrared IR1 is not irradiated to the living body LB.
  • the detector 41 detects the intensity D of the incoming infrared IR coming from the living body LB while the infrared IR1 is irradiating the living body LB.
  • the controller 51 calibrates the blood glucose level measuring device 1 based on the detected intensity D.
  • the controller 51 causes the shutter 32 to open the optical path of the infrared IR2 after the blood glucose level measuring device 1 is calibrated. As a result, the infrared IR2 is irradiated to the living body LB. At this time, the infrared IR2 is focused on the surface of the living body LB by the optical system 22.
  • the controller 51 causes the shutter 32 to close the optical path of the infrared IR2 when a set time has elapsed since the optical path of the infrared IR2 was opened. As a result, the infrared IR2 is not irradiated to the living body LB.
  • controller 51 ends the thermal radiation of the infrared rays IR1 and IR2 to the infrared radiators 11 and 12 after the optical path of the infrared IR2 is closed.
  • the detector 41 detects the intensity D of the incoming infrared IR coming from the living body LB while the infrared IR2 is irradiating the living body LB.
  • the calculator 61 calculates the blood glucose level from the detected intensity D.
  • the infrared radiators 11 and 12 have radiation surfaces 11R and 12R, respectively.
  • the infrared radiators 11 and 12 thermally radiate infrared IR1 and IR2 from the radiation surfaces 11R and 12R, respectively.
  • the infrared radiators 11 and 12 include metamaterials 111 and 121, respectively.
  • the metamaterials 111 and 121 are arranged along the radial surfaces 11R and 12R, respectively.
  • Metamaterials 111 and 121 have different structures from each other.
  • the peak wavelengths ⁇ 1 and ⁇ 2 are wavelengths corresponding to the structures of the metamaterials 111 and 121, respectively. Therefore, the peak wavelengths ⁇ 1 and ⁇ 2 are different from each other.
  • the metamaterials 111 and 121 have a periodic structure including a plurality of pattern pieces periodically arranged in a direction parallel to the radial surfaces 11R and 12R, respectively. Further, the peak wavelengths ⁇ 1 and ⁇ 2 are wavelengths corresponding to the patterns of the periodic structures 111 and 121, respectively.
  • the radial surfaces 11R and 12R are two groups of radial surfaces.
  • the metamaterials 111 and 121 are two groups of metamaterials.
  • the number of radiation surface groups and the number of metamaterial groups may be increased or decreased.
  • each of the infrared radiators 11 and 12 includes a heat radiation plate 71A, a heat radiation plate 71B, and a heater 81.
  • the heater 81 heats the heat radiating plates 71A and 71B to supply heat to the heat radiating plates 71A and 71B.
  • the heat radiating plates 71A and 71B convert the supplied heat into the infrared IRA and IRB shown in FIG. 1, respectively. Further, the heat radiating plates 71A and 71B radiate infrared rays IRA and IRB, respectively.
  • each of the infrared radiators 11 and 12 has radiation surfaces 71AR and 71BR. Further, each of the infrared radiators 11 and 12 thermally radiates infrared IRA and IRB from the radiation surfaces 71AR and 71BR, respectively.
  • the radiation surfaces 71AR and 71BR of the infrared radiator 11 constitute the radiation surface 11R.
  • the radiation surfaces 71AR and 71BR of the infrared radiator 12 constitute the radiation surface 12R.
  • the infrared IRA and IRB emitted by the infrared radiator 11 constitute the infrared IR1.
  • the infrared IRA and IRB emitted by the infrared radiator 12 constitute the infrared IR2.
  • the heat radiating plates 71A and 71B include metamaterials 71A1 and 71B1, respectively. Therefore, each of the infrared radiators 11 and 12 includes metamaterials 71A1 and 71B1.
  • the metamaterials 71A1 and 71B1 are arranged along the radial surfaces 71AR and 71BR, respectively.
  • the metamaterials 71A1 and 71B1 provided in the infrared radiator 11 constitute the metamaterial 111.
  • the metamaterials 71A1 and 71B1 provided in the infrared radiator 12 constitute the metamaterial 121.
  • Metamaterials 71A1 and 71B1 have the same structure.
  • the peak wavelengths of the infrared IRA and IRB are wavelengths corresponding to the structures of the metamaterials 71A1 and 71B1, respectively. Therefore, the peak wavelengths of the infrared IRA and IRB are the same wavelength.
  • the metamaterials 71A1 and 71B1 have a periodic structure including a plurality of pattern pieces periodically arranged in a direction parallel to the radial surfaces 71AR and 71BR, respectively. Further, the peak wavelengths of the infrared IRA and IRB are wavelengths corresponding to the patterns of the periodic structures 71A1 and 71B1, respectively.
  • the heat radiating plates 71A and 71B provided in each of the infrared radiators 11 and 12 are two heat radiating plates. Further, the infrared rays IRA and IRB thermally radiated by each of the infrared radiators 11 and 12 are two infrared rays. Further, the radiation surfaces 71AR and 71BR of the infrared radiators 11 and 12, respectively, are two radiation surfaces. Further, the metamaterials 71A1 and 71B1 provided in each of the infrared radiators 11 and 12 are two metamaterials. Further, the heater 81 is sandwiched between two heat radiating plates 71A and 71B.
  • the optical systems 21 and 22 include parabolic mirrors 101 and 102, respectively. Further, the optical systems 21 and 22 include lenses 141 and 142, respectively.
  • the parabolic mirrors 101 and 102 have focal points 101F and 102F, respectively. Further, the parabolic mirrors 101 and 102 have reflective surfaces 101R and 102R, respectively. Further, the parabolic mirrors 101 and 102 have rotational symmetry axes 101S and 102S, respectively.
  • the reflective surfaces 101R and 102R are rotating paraboloids formed by rotating a parabola around the axes of rotational symmetry 101S and 102S, respectively.
  • Infrared radiators 11 and 12 are arranged at focal points 101F and 102F, respectively.
  • the reflecting surfaces 101R and 102R reflect the heat-radiated infrared rays IR1 and IR2, respectively. Since the infrared radiators 11 and 12 are arranged at the focal points 101F and 102F, respectively, the reflected infrared rays IR1 and IR2 become parallel light fluxes.
  • the lenses 141 and 142 collect the reflected infrared rays IR1 and IR2, respectively.
  • the optical systems 21 and 22 can collect the heat-radiated infrared rays IR1 and IR2, respectively.
  • the radiation surfaces 71AR and 71BR of the infrared radiator 11 face a direction perpendicular to the direction in which the rotational symmetry axis 101S extends, and face different directions from each other.
  • the radiation surfaces 71AR and 71BR of the infrared radiator 11 face 180 ° different directions from each other.
  • the radiation surfaces 71AR and 71BR of the infrared radiator 12 face in a direction perpendicular to the direction in which the rotational symmetry axis 102S extends, and face in different directions from each other.
  • the radiation surfaces 71AR and 71BR of the infrared radiator 12 face 180 ° different directions from each other.
  • FIG. 4 is a perspective view schematically showing a heat radiation plate provided in the blood glucose level measuring device of the first embodiment.
  • each of the heat radiating plates 71A and 71B includes a substrate 151, a conductor layer 152, a dielectric layer 153, and a conductor pattern 154.
  • the conductor layer 152, the dielectric layer 153, and the conductor pattern 154 are arranged on one main surface of the substrate 151.
  • the dielectric layer 153 is arranged on the conductor layer 152.
  • the conductor pattern 154 is arranged on the dielectric layer 153.
  • the conductor pattern 154 includes a plurality of pattern pieces 161.
  • the plurality of pattern pieces 161 are arranged in a matrix.
  • a plurality of pattern pieces 161 may be arranged in a non-matrix form.
  • the substrate 151 is composed of SiO 2.
  • the substrate 151 may be made of a material other than SiO 2.
  • the conductor layer 152 is made of Au.
  • the conductor layer 152 may be made of a material other than Au.
  • the dielectric layer 153 is composed of Al 2 O 3.
  • the dielectric layer 153 may be made of a material other than Al 2 O 3.
  • the conductor pattern 154 is composed of Au.
  • the conductor pattern 154 may be made of a material other than Au.
  • the conductor layer 152, the dielectric layer 153, and the conductor pattern 154 provided in the heat radiating plates 71A and 71B constitute the metamaterials 71A1 and 71B1, respectively.
  • the conductor layer 152, the dielectric layer 153, and the conductor pattern 154 provided in the heat radiating plates 71A and 71B have a surface fine structure having a period similar to the wavelengths of the infrared IRA and IRB, respectively.
  • the heater 81 heats the heat radiating plates 71A and 71B from the other main surface side of the substrate 151.
  • infrared IRA and IRB are thermally radiated from the radiation surfaces 71AR and 71BR on which the conductor pattern 154 is arranged, respectively.
  • the heat-radiated infrared IRA and IRB contain a large amount of specific wavelength components that resonate with the conductor pattern 154. Therefore, the heat-radiated infrared rays IRA and IRB have a peak wavelength corresponding to the conductor pattern 154. Therefore, the heat radiating plates 71A and 71B function as selective radiating plates that selectively radiate a specific wavelength component.
  • the specific wavelength component can be changed by changing the conductor pattern 154.
  • FIG. 5 shows an example of an infrared radiant energy spectrum thermally radiated by an infrared radiator provided in the blood glucose level measuring device of the first embodiment and an infrared radiant energy spectrum thermally radiated by a normal infrared heater. It is a graph. In FIG. 5, radiant energy is taken on the vertical axis. Further, the wavelength is taken on the horizontal axis.
  • the width of the peak of the infrared radiant energy spectrum emitted by the infrared radiators 11 and 12 is significantly narrower than the width of the peak of the infrared radiant energy spectrum thermally emitted by a normal infrared heater. It has become.
  • the blood glucose level measuring device 1 can measure the blood glucose level non-invasively.
  • the heat radiating plates 71A and 71B convert the heat supplied by the heater 81 into infrared IRA and IRB. Therefore, the infrared radiators 11 and 12 do not require a cooling system. This is because if the temperatures of the infrared radiators 11 and 12 are too high, the heat supplied by the heater 81 may simply be reduced.
  • Infrared radiators 11 and 12 also have high energy efficiency.
  • the blood glucose level measuring device 1 the amount of infrared IR1 and IR2 absorbed by glucose using the infrared IR1 and IR2 heat-radiated by the infrared radiators 11 and 12 which do not require a cooling system and have high energy efficiency. Is identified. As a result, the size of the blood glucose level measuring device 1 that measures the blood glucose level in a non-invasive manner can be reduced. In addition, the cost of the blood glucose level measuring device 1 can be reduced. In addition, the output of the light source provided in the blood glucose level measuring device 1 can be increased.
  • the infrared radiators 11 and 12 have an advantage that the radiant energy of the infrared IR1 and IR2 that radiate heat can be easily increased by increasing the area of the radiation surfaces 11R and 12R.
  • the infrared radiators 11 and 12 have a characteristic that the thermal radiation of the infrared IR1 and IR2 cannot be started and stopped instantaneously.
  • the optical paths of the infrared IR1 and IR2 are opened and closed by the shutters 31 and 32, the heat radiation of the infrared IR1 and IR2 cannot be started and stopped instantaneously.
  • the irradiation of the infrared IR1 and IR2 to the living body LB can be started and stopped instantly.
  • the infrared rays IR1 and IR2 irradiated to the living body LB may be converted into pulsed infrared rays, and the intensity of the incoming infrared rays AIR may be detected in synchronization with the pulsed infrared rays.
  • FIG. 6 is a cross-sectional view schematically illustrating the blood glucose level measuring device of the second embodiment.
  • FIG. 7 is a cross-sectional view schematically illustrating an infrared radiator provided in the blood glucose level measuring device of the second embodiment.
  • FIG. 3 is also a graph showing an example of a glucose absorbance spectrum and an infrared radiation intensity spectrum thermally radiated by an infrared radiator provided in the blood glucose level measuring device of the second embodiment.
  • FIG. 4 is also a perspective view schematically illustrating a heat radiation plate provided in the blood glucose level measuring device of the second embodiment.
  • the blood glucose level measuring device 2 of the second embodiment shown in FIG. 6 is different from the blood glucose level measuring device 1 of the first embodiment shown in FIG. Regarding the points not explained, the same configuration as that adopted in the blood glucose level measuring device 1 is also adopted in the blood glucose level measuring device 2.
  • the blood glucose level measuring device 2 of the second embodiment shown in FIG. 6 is a wavelength-independent blood glucose level measuring device in which each of the infrared rays IR1 and IR2 irradiated to the living body LB has only one peak wavelength.
  • each of the infrared radiators 11 and 12 includes a heat radiating plate 70 and a heater 81.
  • the heater 81 heats the heat radiating plate 70 and supplies heat to the heat radiating plate 70.
  • the heat radiating plate 70 converts the supplied heat into the infrared IR shown in FIG. Further, the heat radiating plate 70 radiates infrared IR heat.
  • the heat radiation plate 70 has a radiation surface 70R. Therefore, each of the infrared radiators 11 and 12 has a radiation surface 70R. Further, each of the infrared radiators 11 and 12 thermally radiates the infrared IR from the radiation surface 70R.
  • the radiation surface 70R of the infrared radiator 11 constitutes the radiation surface 11R.
  • the radiation surface 70R of the infrared radiator 12 constitutes the radiation surface 12R.
  • the infrared IR emitted by the infrared radiator 11 constitutes the infrared IR1.
  • the infrared IR emitted by the infrared radiator 12 constitutes the infrared IR2.
  • the heat radiation plate 70 includes a metamaterial 701. Therefore, each of the infrared radiators 11 and 12 includes a metamaterial 701.
  • the metamaterial 701 is arranged along the radial surface 70R.
  • the metamaterial 701 provided in the infrared radiator 11 constitutes the metamaterial 111.
  • the metamaterial 701 provided in the infrared radiator 12 constitutes the metamaterial 121.
  • the metamaterial 701 is a periodic structure including a plurality of pattern pieces periodically arranged in a direction parallel to the radiation surface 70. Further, the peak wavelength of the infrared IR is a wavelength corresponding to the pattern of the periodic structure 701.
  • the heat radiating plate 70 provided in each of the infrared radiators 11 and 12 is one heat radiating plate. Further, the infrared IR thermally radiated by each of the infrared radiators 11 and 12 is one infrared ray. Further, each radiation surface 70R of the infrared radiators 11 and 12 is one radiation surface. Further, the metamaterial 701 provided in each of the infrared radiators 11 and 12 is one metamaterial.
  • the optical systems 21 and 22 include waveguides 201 and 202, respectively.
  • the waveguides 201 and 202 have reflective surfaces 201R and 202R, respectively. Further, the waveguides 201 and 202 have outlets 201E and 202E, respectively. Further, the waveguides 201 and 202 have in-tube spaces 201S and 202S, respectively.
  • the reflective surfaces 201R and 202R are the inner surfaces of the waveguides 201 and 202, respectively.
  • the in-pipe spaces 201S and 202S are surrounded by the reflective surfaces 201R and 202R, respectively.
  • the in-pipe spaces 201S and 202S reach the outlets 201E and 202E, respectively.
  • the in-pipe spaces 201S and 202S have diameters that decrease as they approach the outlets 201E and 202E, respectively.
  • the infrared radiators 11 and 12 are arranged in the pipe spaces 201S and 202S, respectively.
  • the radial surfaces 11R and 12R face toward the exits 201E and 202E.
  • the reflecting surfaces 201R and 202R reflect the heat-radiated infrared rays IR1 and IR2, respectively.
  • the outlet 201E emits the heat-radiated infrared IR1 and the heat-radiated and reflected infrared IR1.
  • the outlet 202E emits the heat-radiated infrared IR2 and the heat-radiated and reflected infrared IR2. Since the in-pipe spaces 201S and 202S have diameters that become smaller as they approach the exit ports 201E and 202E, the emitted infrared rays IR1 and IR2 are focused.
  • the size of the blood glucose level measuring device 2 that measures the blood glucose level in a non-invasive manner can be reduced as in the blood glucose level measuring device 1.
  • the cost of the blood glucose level measuring device 2 can be reduced.
  • the output of the light source provided in the blood glucose level measuring device 2 can be increased.
  • FIG. 8 is a cross-sectional view schematically illustrating the blood glucose level measuring device of the third embodiment.
  • FIG. 9 is a cross-sectional view schematically illustrating an infrared radiator provided in the blood glucose level measuring device of the third embodiment.
  • FIG. 10 is a graph showing an example of an absorption spectrum of glucose and an infrared radiation intensity spectrum thermally radiated by an infrared radiator provided in the blood glucose level measuring device of the third embodiment.
  • the vertical axis represents the absorbance and the radiant intensity.
  • the wave number is taken on the horizontal axis.
  • FIG. 4 is also a perspective view schematically illustrating a heat radiation plate provided in the blood glucose level measuring device of the third embodiment.
  • the blood glucose level measuring device 3 of the third embodiment shown in FIG. 8 is different from the blood glucose level measuring device 1 of the first embodiment shown in FIG. Regarding the points not explained, the same configuration as that adopted in the blood glucose level measuring device 1 is also adopted in the blood glucose level measuring device 3.
  • the blood glucose level measuring device 3 of the third embodiment shown in FIG. 8 is a wavelength mixed type blood glucose level measuring device in which each of the infrared rays IR1 and IR2 irradiated to the living body LB has two or more peak wavelengths different from each other. ..
  • the infrared IR1 illustrated in FIG. 8 has peak wavelengths ⁇ 1 and ⁇ 2.
  • the infrared IR2 illustrated in FIG. 8 has peak wavelengths ⁇ 3 and ⁇ 4.
  • the peak wavelengths ⁇ 3 and ⁇ 4 are different from the peak wavelengths ⁇ 1 and ⁇ 2. Therefore, the infrared IR1 and IR2 have different peak wavelengths from each other.
  • Metamaterials 111 and 121 have different structures from each other.
  • the peak wavelengths ⁇ 1 and ⁇ 2 are wavelengths corresponding to the structure of the metamaterial 111.
  • the peak wavelengths ⁇ 3 and ⁇ 4 are wavelengths corresponding to the structure of the metamaterial 121. Therefore, the peak wavelengths ⁇ 3 and ⁇ 4 are different from the peak wavelengths ⁇ 1 and ⁇ 2.
  • the metamaterials 111 and 121 have a periodic structure including a plurality of pattern pieces periodically arranged in a direction parallel to the radial surfaces 11R and 12R, respectively. Further, the peak wavelengths ⁇ 1 and ⁇ 2 are wavelengths corresponding to the pattern of the periodic structure 111. Further, the peak wavelengths ⁇ 3 and ⁇ 4 are wavelengths corresponding to the pattern of the periodic structure 121.
  • Each of the infrared radiators 11 and 12 thermally radiates infrared IRA and IRB.
  • the metamaterials 71A1 and 71B1 have different structures from each other.
  • the peak wavelengths of the infrared IRA and IRB are wavelengths corresponding to the structures of the metamaterials 71A1 and 71B1, respectively. Therefore, the peak wavelengths of the infrared IRA and IRB are different from each other.
  • the metamaterials 71A1 and 71B1 have a periodic structure including a plurality of pattern pieces periodically arranged in a direction parallel to the radial surfaces 71AR and 71BR, respectively. Further, the peak wavelengths of the infrared IRA and IRB are wavelengths corresponding to the patterns of the periodic structures 71A1 and 71B1, respectively.
  • the size of the blood glucose level measuring device 3 that measures the blood glucose level in a non-invasive manner can be reduced as in the blood glucose level measuring device 1.
  • the cost of the blood glucose level measuring device 3 can be reduced.
  • the output of the light source provided in the blood glucose level measuring device 3 can be increased.
  • FIG. 11 is a cross-sectional view schematically illustrating the blood glucose level measuring device of the fourth embodiment.
  • FIG. 12 is a cross-sectional view schematically illustrating an infrared radiator provided in the blood glucose level measuring device of the fourth embodiment.
  • FIG. 13 is a plan view schematically showing an infrared radiator provided in the blood glucose level measuring device of the fourth embodiment.
  • FIG. 10 is also a graph showing an example of a glucose absorbance spectrum and an infrared radiation intensity spectrum thermally radiated by an infrared radiator provided in the blood glucose level measuring device of the fourth embodiment.
  • FIG. 4 is also a perspective view schematically illustrating a heat radiation plate provided in the blood glucose level measuring device of the fourth embodiment.
  • the blood glucose level measuring device 4 of the fourth embodiment shown in FIG. 11 is different from the blood glucose level measuring device 2 of the second embodiment shown in FIG. Regarding the points not explained, the same configuration as that adopted in the blood glucose level measuring device 2 is also adopted in the blood glucose level measuring device 4.
  • the blood glucose level measuring device 4 of the fourth embodiment shown in FIG. 11 is a wavelength mixed type blood glucose level measuring device in which each of the infrared rays IR1 and IR2 irradiated to the living body LB has two or more peak wavelengths different from each other. ..
  • the infrared IR1 illustrated in FIG. 11 has peak wavelengths ⁇ 1 and ⁇ 2.
  • the infrared IR2 illustrated in FIG. 11 has peak wavelengths ⁇ 3 and ⁇ 4.
  • the peak wavelengths ⁇ 3 and ⁇ 4 are different from the peak wavelengths ⁇ 1 and ⁇ 2. Therefore, the infrared IR1 and IR2 have different peak wavelengths from each other.
  • Metamaterials 111 and 121 have different structures from each other.
  • the peak wavelengths ⁇ 1 and ⁇ 2 are wavelengths corresponding to the structure of the metamaterial 111.
  • the peak wavelengths ⁇ 3 and ⁇ 4 are wavelengths corresponding to the structure of the metamaterial 121. Therefore, the peak wavelengths ⁇ 3 and ⁇ 4 are different from the peak wavelengths ⁇ 1 and ⁇ 2.
  • the metamaterials 111 and 121 have a periodic structure including a plurality of pattern pieces periodically arranged in a direction parallel to the radial surfaces 11R and 12R, respectively. Further, the peak wavelengths ⁇ 1 and ⁇ 2 are wavelengths corresponding to the patterns of the periodic structures 111 and 121, respectively.
  • the heat radiation plate 70 has radiation surfaces 71AR and 71BR. Therefore, each of the infrared radiators 11 and 12 has radiation surfaces 71AR and 71BR. Further, each of the infrared radiators 11 and 12 thermally radiates the infrared IRA and IRB shown in FIG. 11 from the radiation surfaces 71AR and 71BR, respectively.
  • the radiation surfaces 71AR and 71BR of the infrared radiator 11 constitute the radiation surface 11R.
  • the radiation surfaces 71AR and 71BR of the infrared radiator 12 constitute the radiation surface 12R.
  • the infrared IRA and IRB thermally radiated by the infrared radiator 11 constitute the infrared IR1.
  • the infrared IRA and IRB thermally radiated by the infrared radiator 12 constitute the infrared IR2.
  • the heat radiation plate 70 includes metamaterials 71A1 and 71B1, respectively. Therefore, each of the infrared radiators 11 and 12 includes metamaterials 71A1 and 71B1.
  • the metamaterials 71A1 and 71B1 are arranged along the radial surfaces 71AR and 71BR, respectively.
  • the metamaterials 71A1 and 71B1 provided in the infrared radiator 11 constitute the metamaterial 111.
  • the metamaterials 71A1 and 71B1 provided in the infrared radiator 12 constitute the metamaterial 121.
  • the metamaterials 71A1 and 71B1 have different structures from each other.
  • the peak wavelengths of the infrared IRA and IRB are wavelengths corresponding to the structures of the metamaterials 71A1 and 71B1, respectively. Therefore, the peak wavelengths of the infrared IRA and IRB are different from each other.
  • the metamaterials 71A1 and 71B1 have a periodic structure including a plurality of pattern pieces periodically arranged in a direction parallel to the radial surfaces 71AR and 71BR, respectively. Further, the peak wavelengths of the infrared IRA and IRB are wavelengths corresponding to the patterns of the periodic structures 71A1 and 71B1, respectively.
  • the size of the blood glucose level measuring device 4 that measures the blood glucose level in a non-invasive manner can be reduced as in the blood glucose level measuring device 1.
  • the cost of the blood glucose level measuring device 4 can be reduced.
  • the output of the light source provided in the blood glucose level measuring device 4 can be increased.
  • FIG. 14 is a cross-sectional view schematically showing the blood glucose level measuring device of the fifth embodiment.
  • FIG. 15 is a cross-sectional view schematically illustrating an infrared radiator provided in the blood glucose level measuring device of the fifth embodiment.
  • FIG. 16 is also a plan view schematically illustrating an infrared radiator provided in the blood glucose level measuring device of the fifth embodiment.
  • FIG. 3 is also a graph showing an example of a glucose absorbance spectrum and an infrared radiation intensity spectrum thermally radiated by an infrared radiator provided in the blood glucose level measuring device of the fifth embodiment.
  • FIG. 4 is also a perspective view schematically illustrating a heat radiation plate provided in the blood glucose level measuring device of the fifth embodiment.
  • the blood glucose level measuring device 5 of the fifth embodiment shown in FIG. 14 is different from the blood glucose level measuring device 1 of the first embodiment shown in FIG. Regarding the points not explained, the same configuration as that adopted in the blood glucose level measuring device 1 is also adopted in the blood glucose level measuring device 5.
  • the blood glucose level measuring device 5 of the fifth embodiment shown in FIG. 14 is a wavelength-independent blood glucose level measuring device in which each of the infrared rays IR1 and IR2 irradiated to the living body LB has only one peak wavelength.
  • the blood glucose level measuring device 5 of the fifth embodiment includes an infrared radiator 10, a shutter 31, a shutter 32, a detector 41, a controller 51, and a calculator 61.
  • the detector 41 detects an amount D that reflects the amount of infrared rays IR1 and IR2 absorbed by glucose in the living body LB.
  • the detector 41 is an acoustic wave detector.
  • the detected amount D is the intensity of the acoustic wave AW arriving from the living body LB while the infrared rays IR1 and IR2 are irradiated on the living body LB.
  • the acoustic wave detector is a microphone.
  • the acoustic wave detector may be an acoustic wave detector other than a microphone.
  • the acoustic wave AW is an acoustic wave generated by the photoacoustic effect when glucose absorbs infrared rays IR1 and IR2.
  • the infrared radiator 10 has a plurality of radiation surfaces 11R and 12R.
  • the infrared radiator 10 thermally radiates infrared IR1 and IR2 from the radiation surfaces 11R and 12R, respectively.
  • the radial surfaces 11R and 12R face the same direction.
  • the infrared radiator 10 includes metamaterials 111 and 121.
  • the metamaterials 111 and 121 are arranged along the radial surfaces 11R and 12R, respectively.
  • Metamaterials 111 and 121 have different structures from each other.
  • the peak wavelengths ⁇ 1 and ⁇ 2 are wavelengths corresponding to the structures of the metamaterials 111 and 121, respectively. Therefore, the peak wavelengths ⁇ 1 and ⁇ 2 are different from each other. Therefore, the infrared IR1 and IR2 have different peak wavelengths from each other.
  • the metamaterials 111 and 121 have a periodic structure including a plurality of pattern pieces periodically arranged in a direction parallel to the radial surfaces 11R and 12R, respectively. Further, the peak wavelengths ⁇ 1 and ⁇ 2 are wavelengths corresponding to the patterns of the periodic structures 111 and 121, respectively.
  • the infrared radiator 10 includes a heat radiating plate 70 and a heater 81.
  • the heat radiation plate 70 has radiation surfaces 11R and 12R.
  • the size of the blood glucose level measuring device 5 that measures the blood glucose level in a non-invasive manner can be reduced as in the blood glucose level measuring device 1.
  • the cost of the blood glucose level measuring device 5 can be reduced.
  • the output of the light source provided in the blood glucose level measuring device 5 can be increased.
  • the intensity of the acoustic wave AW arriving from a wide range can be easily detected. Therefore, it is not necessary to collect the infrared rays IR1 and IR2, and the optical system that collects the infrared rays IR1 and IR2 can be omitted.
  • FIGS. 17 to 19 are perspective views schematically illustrating another example of the heat radiating plate provided in the blood glucose level measuring devices of the first to fifth embodiments.
  • Each of the heat radiating plates 71A, 71B and 70 may be a heat radiating plate other than the heat radiating plate shown in FIG.
  • each of the heat radiating plates 71A, 71B and 70 may be the heat radiating plate shown in FIG. 17, FIG. 18 or FIG.
  • Each of the heat radiating plates 71A, 71B and 70 illustrated in FIG. 17 includes a conductor layer 801.
  • a plurality of microcavities 802 are formed in the conductor layer 801.
  • the plurality of microcavities 802 are arranged in a matrix.
  • the conductor layer 801 provided in the heat radiating plates 71A, 71B and 70 constitutes the metamaterials 71A1, 71B1 and 701, respectively.
  • Each of the heat radiating plates 71A, 71B and 70 illustrated in FIG. 18 includes a conductor layer 811, a dielectric layer 812 and a conductor pattern 813.
  • the dielectric layer 812 is arranged on the conductor layer 811.
  • the conductor pattern 813 is arranged on the dielectric layer 812.
  • the conductor pattern 813 includes a plurality of split rings 814.
  • the plurality of split rings 814 are arranged in a matrix.
  • the conductor layer 811, the dielectric layer 812, and the conductor pattern 813 provided in the heat radiating plates 71A, 71B and 70 constitute the metamaterials 71A1, 71B1 and 701, respectively.
  • Each of the heat radiating plate 71A, 71B and 70, illustrated in FIG. 19 comprises a W layer 821, SiO 2 layer 822, Ge layer 823, SiO 2 layer 824, Ge layer 825, SiO 2 layer 826 and Ge layers 827 .
  • the W layer 821, the SiO 2 layer 822, the Ge layer 823, the SiO 2 layer 824, the Ge layer 825, the SiO 2 layer 826, and the Ge layer 827 are laminated from bottom to top in the order described.
  • the W layer 821, SiO 2 layer 822, Ge layer 823, SiO 2 layer 824, Ge layer 825, SiO 2 layer 828 and Ge layer 827 provided in the heat radiating plates 71A, 71B and 70 are metamaterials 71A1, 71B1 and 701. Are configured respectively.

Abstract

La présente invention réduit la taille d'un dispositif de mesure de glycémie pour mesurer de manière non invasive le taux de glycémie, réduit le coût du dispositif de mesure de glycémie et augmente la sortie d'une source lumineuse disposée dans le dispositif de mesure de glycémie. Le dispositif de mesure de glycémie comporte un radiateur infrarouge et un détecteur. Le radiateur infrarouge présente une surface de rayonnement. Le radiateur infrarouge est pourvu d'un métamatériau. Le radiateur infrarouge émet de la chaleur infrarouge à partir de la surface de rayonnement. La longueur d'onde maximale du rayonnement infrarouge dépend de la structure du métamatériau. Le détecteur détecte une quantité qui reflète la quantité de rayonnement infrarouge absorbée par le glucose dans un corps vivant.
PCT/JP2020/020545 2020-05-25 2020-05-25 Dispositif de mesure de glycémie WO2021240600A1 (fr)

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001025465A (ja) * 1999-04-30 2001-01-30 Lilienfeld-Toal Hermann V 物質を検出する装置及び方法
CN101536910A (zh) * 2009-04-09 2009-09-23 上海理工大学 光纤传感的肺动脉血氧饱和度监测装置
JP2016509868A (ja) * 2013-02-13 2016-04-04 ルマン・ミクロ・デバイシズ・ソシエテ・アノニムＬｅｍａｎ Ｍｉｃｒｏ Ｄｅｖｉｃｅｓ Ｓａ 非侵襲的血液分析
JP2017507722A (ja) * 2014-02-26 2017-03-23 メディカル ワイヤレス センシング リミテッド センサ
JP2017519509A (ja) * 2014-06-27 2017-07-20 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 動物バイタルサイン検出システム
WO2018123369A1 (fr) * 2016-12-26 2018-07-05 三菱電機株式会社 Dispositif de mesure de substance biologique
WO2019009288A1 (fr) * 2017-07-05 2019-01-10 日本碍子株式会社 Dispositif de traitement infrarouge

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001025465A (ja) * 1999-04-30 2001-01-30 Lilienfeld-Toal Hermann V 物質を検出する装置及び方法
CN101536910A (zh) * 2009-04-09 2009-09-23 上海理工大学 光纤传感的肺动脉血氧饱和度监测装置
JP2016509868A (ja) * 2013-02-13 2016-04-04 ルマン・ミクロ・デバイシズ・ソシエテ・アノニムＬｅｍａｎ Ｍｉｃｒｏ Ｄｅｖｉｃｅｓ Ｓａ 非侵襲的血液分析
JP2017507722A (ja) * 2014-02-26 2017-03-23 メディカル ワイヤレス センシング リミテッド センサ
JP2017519509A (ja) * 2014-06-27 2017-07-20 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 動物バイタルサイン検出システム
WO2018123369A1 (fr) * 2016-12-26 2018-07-05 三菱電機株式会社 Dispositif de mesure de substance biologique
WO2019009288A1 (fr) * 2017-07-05 2019-01-10 日本碍子株式会社 Dispositif de traitement infrarouge

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