WO2021238689A1

WO2021238689A1 - Chinese medicine composition for soothing nerves and aiding sleep, and chinese medicine sachet and application

Info

Publication number: WO2021238689A1
Application number: PCT/CN2021/094018
Authority: WO
Inventors: 程亚伟; 丁一; 陈磊; 林尤海; 程亚博; 袁冬梅; 何创; 蔡媛媛; 王珊; 颜芬; 王紫薇; 杨媛; 林道斌
Original assignee: 程亚伟
Priority date: 2020-05-29
Filing date: 2021-05-17
Publication date: 2021-12-02
Also published as: CN111494513A

Abstract

A Chinese medicine composition for soothing nerves and aiding sleep, and a Chinese medicine sachet and an application. The Chinese medicine composition comprises the following raw materials: rose flower, julibrissin flower, Juncus effusus, rosemary, agarwood, sandalwood, costus root and Korean mint.

Description

Traditional Chinese medicine composition for calming nerves and aiding sleep, and Chinese medicine sachet and application

Technical field

The invention relates to the technical field of traditional Chinese medicine sachets, in particular to a traditional Chinese medicine composition for tranquilizing the nerves and aiding sleep, as well as traditional Chinese medicine sachets and applications.

Background technique

Insomnia is a sleep disorder characterized by frequent and continuous difficulty falling asleep and/or difficulty maintaining sleep and leading to unsatisfactory sleep. The patient usually suffers from insomnia, difficulty falling asleep, dreaming and waking up easily. Seriously affect the patient's quality of life and work efficiency. Traditional Chinese medicine sachets can be worn on the body and absorbed through the respiratory tract or skin to play their role in disease prevention and treatment. The present invention aims to provide a traditional Chinese medicine composition, which can be made into traditional Chinese medicine sachets, etc., which can significantly improve the symptoms of insomnia.

Summary of the invention

In view of this, the present invention proposes a Chinese medicinal composition and Chinese medicinal sachet for calming the nerves and aiding sleep, and applications.

The technical scheme of the present invention is realized as follows: a traditional Chinese medicine composition for calming the nerves and aiding sleep, the active components of which include the following raw materials by weight: 8-12 parts by weight of roses, 8-15 parts by albizia, and 8 parts by rush. -13 parts, 8-13 parts of rosemary, 8-15 parts of agarwood, 5-12 parts of sandalwood, 8-13 parts of woody, 5-12 parts of ageratum.

Preferably, the active component of the traditional Chinese medicine composition includes the following raw materials in parts by weight: 10 parts of rose, 13 parts of Albizia julibrissin, 11 parts of rush, 12 parts of rosemary, 10 parts of agarwood, 8 parts of sandalwood, wood 11 parts of incense, 8 parts of Huoxiang.

A traditional Chinese medicine sachet for soothing the nerves and aiding sleep, comprising the traditional Chinese medicine composition for soothing the nerves and aiding sleep as described in any one of the present invention.

The application of the traditional Chinese medicine composition according to any one of the present invention in the preparation of a medicine for tranquilizing the nerves and assisting sleep.

Compared with the prior art, the beneficial effects of the present invention are:

In the prescription of the present invention, Albizia Julibrissin is an emperor medicine for relieving depression and soothing the nerves, rushes for clearing the heart and eliminating troubles, rosemary for invigorating the spleen and soothing the nerves, agarwood for invigorating the body and soothing the nerves, altogether serving as a medicine for ministers, rose flowers for promoting qi and relieving depression, sandalwood, wood incense, and husk Fragrant, aromatic stimulating the spleen to soothe the nerves, a total of adjuvants; the whole prescription has the effect of aromatic depression, soothing the nerves and aiding sleep. It is suitable for the general population, especially for those who have difficulty falling asleep, waking up early, and dreaming. It can significantly improve the symptoms of insomnia.

Detailed ways

In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

The experimental methods used in the embodiments of the present invention are conventional methods unless otherwise specified.

The materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources unless otherwise specified.

The following introduces the basic situation of the main raw materials based on the "Chinese Pharmacopoeia", "Chinese Medicine Dictionary" and "Chinese Herbal Medicine".

Rose: [Nature and Flavor] Sweet, slightly bitter, warm. 【Return Channel】Return to Liver and Spleen Channel. [Functions and Indications] Promoting Qi, relieving depression, relieving blood, and relieving pain. It is used for liver and stomach qi pain, poor appetite, nausea, irregular menstruation, and pain when falling.

Albizia Julibrissin: [nature and flavor] sweet, flat. 【Guijing】Guixin and Liver Channel. 【Functions and Indications】Relieve depression and soothe the nerves. Used for restlessness, depression and insomnia.

Rush: [nature and flavor] sweet, light, slightly cold. 【Guijing】Guixin, lung and small intestine meridian. 【Functions and Indications】Clears the heart and fire, and facilitates urination. Used for upset, insomnia, oliguria, astringent pain, sores on the tongue and mouth.

Rosemary: [nature and flavor] pungent in taste; warm in nature. 【Return meridian】enter the lung, stomach, and spleen meridians. [Functions and Indications] sweating; invigorating the spleen; soothing the nerves; relieving pain. Mainly all kinds of headaches; prevent early hair loss.

Agarwood: [nature and flavor] pungent, bitter, lukewarm. 【Return Channel】Return to Spleen, Stomach and Kidney Channels. [Functions and Indications] Promoting qi to relieve pain, warming to stop vomiting, receiving qi to relieve asthma. It is used for chest and abdomen distension and pain, stomach cold, vomiting, hiccups, kidney deficiency and qi.

Sandalwood: [nature and flavor] pungent, warm. 【Return meridian】Return to the spleen, stomach and lung meridians. 【Functions and Indications】Appetite and relieve pain in the middle of the temperature. It is used for cold coagulation qi stagnation, chest pain, abdominal pain; coronary heart disease, angina pectoris.

Woody: [nature and flavor] pungent, bitter, warm. 【Return meridian】Return to the spleen, stomach, large intestine, triple burnt and gall bladder meridian. 【Functions and Indications】Promoting qi to relieve pain, invigorating the spleen and eliminating food. It is used for chest pain, diarrhea, heavy after diarrhea, food accumulation, reluctance to eat. Simmering wood fragrant and solid intestines to relieve diarrhea. Used for diarrhea and abdominal pain.

Huoxiang: [nature and flavor] pungent, lukewarm. 【Return Channel】Enter the lung, spleen, and stomach channels. 【Functions and Indications】Quick qi, harmonize, eliminate filth, and remove dampness. Cure colds and dampness, cold and heat, headache, chest congestion, vomiting and diarrhea, malaria, dysentery, bad breath.

Example 1

Weigh the raw materials according to the following parts by weight: 10 parts of rose, 10 parts of Albizia julibrissin, 10 parts of rush, 10 parts of rosemary, 10 parts of agarwood, 10 parts of sandalwood, 10 parts of wood incense, and 10 parts of ageratum. The above-mentioned raw material medicine is crushed and packed into a sachet medicine bag to make a traditional Chinese medicine sachet.

Example 2

Weigh the raw materials according to the following parts by weight: 8 parts of rose, 8 parts of Albizia julibrissin, 13 parts of rush, 8 parts of rosemary, 15 parts of agarwood, 12 parts of sandalwood, 8 parts of wood incense, and 12 parts of ageratum. The above-mentioned raw material medicine is crushed and packed into a sachet medicine bag to make a traditional Chinese medicine sachet.

Example 3

Weigh the raw materials according to the following parts by weight: 12 parts of rose, 15 parts of Albizia julibrissin, 8 parts of rush, 13 parts of rosemary, 8 parts of agarwood, 5 parts of sandalwood, 13 parts of wood incense, and 5 parts of ageratum. The above-mentioned raw material medicine is crushed and packed into a sachet medicine bag to make a traditional Chinese medicine sachet.

Example 4

Weigh the raw materials according to the following parts by weight: 10 parts of rose, 13 parts of Albizia julibrissin, 11 parts of rush, 12 parts of rosemary, 10 parts of agarwood, 8 parts of sandalwood, 11 parts of wood incense, and 8 parts of ageratum. The above-mentioned raw material medicine is crushed and packed into a sachet medicine bag to make a traditional Chinese medicine sachet.

Comparative example 1

The difference between this comparative example and Example 4 is that the agarwood is replaced by an equivalent amount of wood incense, and the sandalwood is replaced by an equivalent amount of rosemary. Weigh the raw materials according to the following parts by weight: 10 parts of rose, 13 parts of Albizia julibrissin, 11 parts of rush, 20 parts of rosemary, 21 parts of woody, and 8 parts of ageratum. The above-mentioned raw material medicine is crushed and packed into a sachet medicine bag to make a traditional Chinese medicine sachet.

Comparative example 2

Weigh the raw materials according to the following parts by weight: 5 parts of rose, 3 parts of Albizia julibrissin, 1 part of rush, 3 parts of rosemary, 5 parts of agarwood, 15 parts of sandalwood, 5 parts of wood incense, and 15 parts of ageratum. The above-mentioned raw material medicine is crushed and packed into a sachet medicine bag to make a traditional Chinese medicine sachet.

The Chinese medicine sachet prepared above is applied to the clinic:

1. Basic data: A total of 420 patients with insomnia were collected; all patients met the diagnostic criteria of the "Diagnosis and Curative Effect Standards for Diseases and Syndromes of Traditional Chinese Medicine" and the "Chinese Mental Disorders Classification and Diagnosis Standards" 3rd Edition. The age ranged from 18 to 50 years; they were randomly divided into experimental group 1 to experimental group 6, with 70 cases in each group. The gender distribution and average age of each group are shown in the following table:

2. Use method and course of treatment: Test group 1 to test group 6 use the traditional Chinese medicine sachets of Examples 1 to 4 and Comparative Examples 1 to 2 respectively, and each sachet contains about 25 grams of Chinese medicine. How to use: Place the sachet beside the pillow when sleeping, change the sachet every 7 days, and use the sachet continuously for 3 months. Replace it in time if it gets wet.

3. Efficacy analysis

3.1 Observation indicators

After insomnia curative effect analysis and treatment, curative effect evaluation and SPIEGEL sleep scale test were performed. Observe the scores before and after treatment, and make statistics of the curative effect. The SPIEGEL scale is an internationally used sleep quality assessment scale. Its assessment items include time to fall asleep, total sleep time, number of night awakenings, depth of sleep, dreaming and feelings after waking, and a total of 6 items. Each assessment item adopts a 5-level scoring system. , Each score corresponds to 0, 1, 3, 5 and 7 points, and the final scores of all indicators are added together to get the total score of sleep evaluation. The higher the score, the more significant the insomnia symptoms of the subjects are. Test scores of 9-12 are classified as insomnia; ≥12 are classified as insomnia. Degree of insomnia: ①≥12 is divided into mild insomnia; ②18-24 is divided into moderate insomnia; ③≥24 is divided into severe insomnia.

3.2 Efficacy criteria

Evaluation of clinical total curative effect: According to the SPIEGEL scale score, the curative effect is evaluated by the reduction rate, which is divided into 4 levels: cured, markedly effective, effective, and ineffective.

Recovery: Refers to the complete or almost disappearance of symptoms, and the score reduction rate of SPIEGEL scale is ≥80%;

Markedly effective: Refers to the symptom basically disappeared, the SPIEGEL scale reduction rate is ≥50%;

Effective: Refers to symptom improvement or partial symptom improvement, SPIEGEL scale reduction rate ≥30%;

Invalid: Refers to the symptom no change or aggravation, the SPIEGEL scale deduction rate is less than 30%.

3.3 Treatment results

The above clinical situation shows that the traditional Chinese medicine sachet of the present invention has a significant therapeutic effect for tranquilizing the nerves and assisting sleep, with a marked efficiency of more than 71.4% and a total effective rate of more than 98.6%.

4. Typical cases

Case 1: Ding, female, 39 years old, usually insomnia, difficult to fall asleep, usually tossing and turning around for 2 hours before falling asleep, given the Chinese medicine sachet of Example 4 of the present invention, put the sachet on the pillow when sleeping, and replace 1 every 7 days After using the sachet for 2 weeks, the time to fall asleep is shortened. After using the sachet for 2 months, there is no obvious difficulty in falling asleep. You can fall asleep after about 10 minutes.

Case 2: Luo Mou, male, 54 years old, complained of poor sleep and easy awakening from dreams. He was given a traditional Chinese medicine sachet in Example 1 of the present invention. The sachet was placed by the pillow when sleeping, and the sachet was replaced every 7 days After 1 month, my sleep improved and dreams decreased. After 2 months of continuous use of the sachet, my sleep was basically normal, and I woke up once at night.

5. Safety observation: In all observed cases, no adverse reactions were found.

The foregoing descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the present invention. Within the scope of protection.

Claims

A traditional Chinese medicine composition for calming the nerves and assisting sleep, characterized in that its active components include the following raw materials by weight: 8-12 parts by weight of roses, 8-15 parts of albizia, 8-13 parts of rushes, rosemary 8-13 parts of incense, 8-15 parts of agarwood, 5-12 parts of sandalwood, 8-13 parts of woody, 5-12 parts of ageratum.
The traditional Chinese medicine composition for calming the nerves and assisting sleep according to claim 1, wherein the active ingredient comprises the following raw materials by weight: 10 parts of rose, 13 parts of albizia, 11 parts of rush, 12 parts of rosemary, 10 parts of agarwood, 8 parts of sandalwood, 11 parts of woody, and 8 parts of ageratum.
A traditional Chinese medicine sachet for calming nerves and aiding sleep, characterized in that it contains the traditional Chinese medicine composition for calming nerves and aiding sleep according to any one of claims 1 to 2.
The use of the traditional Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicine for tranquilizing the nerves and assisting sleep.