WO2021235974A1 - Procédé d'étude radiographique à énergies multiples - Google Patents

Procédé d'étude radiographique à énergies multiples Download PDF

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Publication number
WO2021235974A1
WO2021235974A1 PCT/RU2021/000169 RU2021000169W WO2021235974A1 WO 2021235974 A1 WO2021235974 A1 WO 2021235974A1 RU 2021000169 W RU2021000169 W RU 2021000169W WO 2021235974 A1 WO2021235974 A1 WO 2021235974A1
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WIPO (PCT)
Prior art keywords
images
image
sequence
ray
original
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PCT/RU2021/000169
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English (en)
Russian (ru)
Inventor
Заурбек Викторович БУЛАТОВ
Анатолий Рудольфович ДАБАГОВ
Игорь Сергеевич КОБЫЛКИН
Александр Валерьевич ПРОХОРОВ
Владимир Игоревич СПОРЫШ
Юрий Евгеньевич ШУНКОВ
Дмитрий Викторович ПОЗДНЯКОВ
Дмитрий Михайлович КАСЮК
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Акционерное Общество "Медицинские Технологии Лтд"
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Publication of WO2021235974A1 publication Critical patent/WO2021235974A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/02—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
    • G01N23/04—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material

Definitions

  • the present invention relates to the field of medical X-ray technology and can be used in the examination of patients with various diseases, including cancer.
  • the disadvantage of the known method consists in the manifestation of artifacts on the obtained separate images, caused both by the natural rhythmic movement of the patient during the diagnostic study (as a result of breathing and heartbeat), and by possible random changes in the position of his body, which reduces the accuracy of image interpretation.
  • the technical problem solved by the claimed group of inventions consists in creating a method for X-ray examination, which provides the possibility of accurate interpretation of X-ray images and, therefore, obtaining a highly informative dynamic picture of the patient's condition, which ultimately increases the diagnostic value of the study.
  • the technical result is achieved, which consists in the reduction of motion artifacts on the obtained separate images by compensating for the influence of the residual effect of such movement on the information content of these images.
  • the technical problem is solved, and the specified technical result is achieved as a result of the implementation of the X-ray examination method, which includes irradiation of the patient with X-rays as a result of supplying a sequence of voltage pulses of various magnitudes to the X-ray source, obtaining the corresponding sequence of initial X-ray images and building on their basis a sequence of separate images of tissues with different coefficients of linear attenuation.
  • next (n + 1) -th original image is combined with the previous n-th original image by correcting one of them.
  • M p , a N p xM p is the size of each of the compressed images, the formation of a displacement map from them in the scale of the original images D g with its sequential refinement until the final displacement map is obtained and the final corrected image is obtained by shifting the original images according to the final displacement map, which is optional . allows you to avoid the accumulation of defects in the corrected image.
  • a map of displacement increments u n is formed , after obtaining each (n + 1) th image, a corresponding displacement map DG P + I, and then, using the Kalman filter, a refined displacement map Dg ' n +1 is formed from the mathematical expression:
  • the mentioned combined images are mixed, obtaining an additional image with a higher contrast / noise ratio than any of the original images , which further expands the diagnostic capabilities of the study.
  • the claimed method of X-ray examination is implemented as follows.
  • the patient is irradiated with X-ray radiation, for example, in a private embodiment, by supplying to the X-ray source a sequence of three voltage pulses, respectively, Ui, U2, U3. Moreover, U2> Ui, and U3 ⁇ U2 (in another version, U2 ⁇ U), a U3> U2).
  • the pulses are fed using a voltage generator included in the X-ray power supply.
  • the radiation emitted by the source is optionally additionally filtered by passing through a layer of selectively absorbing material.
  • the radiation transmitted through the patient is recorded using an X-ray receiver, optionally equipped with a raster filtering out scattered radiation.
  • next initial X-ray image g is combined with the previous initial image f by correcting one of them, for example, f.
  • the subsequent corrected image f is obtained by shifting the image f according to Ar;
  • a map of displacement increments u n is formed , at each step n + 1, a corresponding displacement map Ar n + i is formed , and then, using the Kalman filter, a refined displacement map Ar ' n + i is formed from the mathematical expression: DG n + l ⁇ + ⁇ + 1 + (1 - Kh + ⁇ ) ⁇ (DG h + Un), where K + i is the Kalman coefficient.
  • Kalman Filtering A Practical Approach. American Institute of Aeronautics and Astronautics, Incorporated, 2000.
  • separate tissue images are constructed, having different linear attenuation coefficients, by applying any suitable algorithm, for example, disclosed in the above-mentioned article by Tong Xu et al.
  • An additional merged image can also be obtained by any suitable method of blending the two images, for example, weighted summation or other method widely known in the art (for example, from E. Davies Machine Vision: Theory, Algorithms and Practicalities, Academic Press, 1990), not specifically disclosed herein.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Image Analysis (AREA)

Abstract

L'invention se rapporte au domaine des techniques radiographiques médicales et peut être utilisée lors de l'examen de patients souffrant de différentes maladies, y compris des maladies oncologiques. L'invention concerne un procédé d'étude radiographique à énergies multiples qui consiste à éclairer un patient avec un rayonnement radiographique suite l'envoi vers une source de rayonnement radiographique d'une séquence d'impulsions ayant une tension de valeur différente, obtenir une séquence correspondante d'images radiographiques initiales et construire sur la base de celles-ci une séquence d'images radiographiques distinctes de tissus ayant différents coefficients d'atténuation linéaire. On envoie sur la source de rayonnement radiographique une séquence de N>3 impulsions de tension dont les valeurs de tension U pour l'un quelconque de n=1...N satisfont la condition: si Un+1>Un, , alors Un+2<Un+1, si Un+1<Un, , alors Un+2>Un+1; après avoir obtenu chaque image initiale séquentielle en commençant depuis la seconde et avant de construire des images distinctes des tissus ayant différents coefficients d'atténuation linéaire, on effectue une combinaison de la (n+1)-ème image initiale séquentielle avec la n-ème image initiale précédente par correction de l'une d'elles. Cette invention permet d'éliminer les artefacts de mouvement sur les images distinctes à produire grâce à une compensation de l'influence de l'effet résiduel d'un tel mouvement sur la capacité informative de ces images.
PCT/RU2021/000169 2020-05-19 2021-04-23 Procédé d'étude radiographique à énergies multiples WO2021235974A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2020116809A RU2740870C1 (ru) 2020-05-19 2020-05-19 Способ мультиэнергетического рентгенологического исследования
RU2020116809 2020-05-19

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WO2021235974A1 true WO2021235974A1 (fr) 2021-11-25

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WO (1) WO2021235974A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2366990C1 (ru) * 2008-04-02 2009-09-10 Государственное образовательное учреждение высшего профессионального образования "Оренбургский государственный университет" Способ мультиэнергетической рентгенографии
US20090283682A1 (en) * 2008-05-19 2009-11-19 Josh Star-Lack Multi-energy x-ray imaging
RU2559167C1 (ru) * 2014-06-17 2015-08-10 Государственное казенное образовательное учреждение высшего профессионального образования Академия Федеральной службы охраны Российской Федерации (Академия ФСО России) Способ мультиэнергетической рентгенографии
US20170172528A1 (en) * 2015-12-21 2017-06-22 General Electric Company Multi-energy x-ray imaging

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2366990C1 (ru) * 2008-04-02 2009-09-10 Государственное образовательное учреждение высшего профессионального образования "Оренбургский государственный университет" Способ мультиэнергетической рентгенографии
US20090283682A1 (en) * 2008-05-19 2009-11-19 Josh Star-Lack Multi-energy x-ray imaging
RU2559167C1 (ru) * 2014-06-17 2015-08-10 Государственное казенное образовательное учреждение высшего профессионального образования Академия Федеральной службы охраны Российской Федерации (Академия ФСО России) Способ мультиэнергетической рентгенографии
US20170172528A1 (en) * 2015-12-21 2017-06-22 General Electric Company Multi-energy x-ray imaging

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATEL RAKESH; PANFIL JOSHUA; CAMPANA MARIA; BLOCK ALEC M.; HARKENRIDER MATTHEW M.; SURUCU MURAT; ROESKE JOHN C.: "Markerless motion tracking of lung tumors using dual-energy fluoroscopy", MEDICAL PHYSICS., AIP, MELVILLE, NY., US, vol. 42, no. 1, 1 January 1901 (1901-01-01), US , pages 254 - 262, XP012193000, ISSN: 0094-2405, DOI: 10.1118/1.4903892 *

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