WO2021232334A1

WO2021232334A1 - Traditional chinese medicine composition having anti-acne effect, preparation method therefor, and use thereof

Info

Publication number: WO2021232334A1
Application number: PCT/CN2020/091506
Authority: WO
Inventors: 贺莲; 陈明宗; 明魏
Original assignee: 极臣生物科技(深圳)有限公司
Priority date: 2020-05-21
Filing date: 2020-05-21
Publication date: 2021-11-25

Abstract

Disclosed are a traditional Chinese medicine composition having an anti-acne effect, a preparation method therefor, and the use thereof, falling within the technical field of traditional Chinese medicine. The traditional Chinese medicine composition comprises the following components in parts by weight: 20-30 parts of Herba dendrobii nobilis, 20-30 parts of Atractylodis macrocephalae rhizoma, 20-30 parts of Paeoniae radix alba, 15-20 parts of pearl powder, 10-20 parts of dried alum, and 5-10 parts of Menthae haplocalycis herba. With regard to treating acne, the external use of the traditional Chinese medicine composition has a healing rate of 58.75%, and the total effective rate thereof is up to 100%; and compared with the external application of tretinoin cream, the healing rate is increased by 46.25% and the total effective rate is increased by 17.5%.

Description

A traditional Chinese medicine composition with acne-removing function and its preparation method and application

Technical field

The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition with acne-removing function, and a preparation method and application thereof.

Background technique

Acne, also known as acne, is a very common chronic inflammatory skin disease of the hair follicles and sebaceous glands. Most patients are in adolescence and will recover naturally by the age of 25. Acne occurs mainly due to excessive secretion of cortex, clogged hair follicle sebaceous duct, bacterial infection and inflammatory reaction, resulting in poor sebum outflow of patients, so acne is formed. For different groups of people, acne will recur repeatedly or cannot be eliminated for a long time. Lose. Generally speaking, acne is manifested by the appearance of papules, blackheads, pustules, nodules, cysts, etc. on the skin surface, which hinder the appearance and bring great mental pressure to the patient.

Traditional Chinese medicine has long discussed acne, and the treatment methods are also based on individual symptoms and skin lesions. According to the four diagnoses of traditional Chinese medicine, acne is mainly divided into the following three types: the lung meridian accumulates heat, the spleen and stomach damp-heat syndrome, and the blood stasis and phlegm coagulation syndrome. Usually, the clinical treatment of acne is to apply drugs on the affected area or squeeze, but it can only treat the symptoms but is difficult to eradicate, failing to achieve the desired effect for the patient.

Summary of the invention

In view of this, the purpose of the present invention is to provide a traditional Chinese medicine composition with anti-acne function and its preparation method and application. The effect of beautifying and beautifying, in the treatment of acne, the recovery rate is 58.75%, and the total effective rate is as high as 100%.

In order to achieve the above-mentioned purpose of the invention, the present invention provides the following technical solutions:

The present invention provides a traditional Chinese medicine composition with anti-acne function, which is characterized in that it comprises the following components by weight: 20-30 parts of Dendrobium nobile, 20-30 parts of Atractylodes, 20-30 parts of white peony, pearl powder 15-20 parts, 10-20 parts of alum and 5-10 parts of mint.

The present invention provides a preparation method of the traditional Chinese medicine composition according to the above technical solution, which comprises: mixing, pulverizing and irradiating the raw materials to sterilize the traditional Chinese medicine composition.

Preferably, after the raw material is pulverized, a pulverized product is obtained, and the pulverized product is sterilized by irradiation, and the particle size of the pulverized product is less than or equal to 830 μm.

Preferably, the particle size of the pulverized product is 48 μm-830 μm.

Preferably, the particle size of the pulverized product is less than 48 μm.

Preferably, the irradiation dose of the irradiation sterilization is 10-15 KGY, and the time of the irradiation sterilization is 13-18h.

Preferably, the irradiation dose of the irradiation sterilization is 13KGY, and the time of the irradiation sterilization is 16h.

The present invention provides the application of the traditional Chinese medicine composition described in the above technical scheme in the preparation of acne-removing drugs for the face.

Compared with the prior art, the present invention has the following beneficial effects:

The present invention provides a traditional Chinese medicine composition with anti-acne function, comprising the following components in parts by weight: 20-30 parts of Dendrobium nobile, 20-30 parts of Atractylodes macrocephala, 20-30 parts of white peony root, 15-20 parts of pearl powder, 10-20 parts of alum and 5-10 parts of mint.

In the present invention, Dendrobium nobile is cold in nature and bitter in taste, and has the functions of clearing away heat and nourishing yin, promoting blood circulation and removing blood stasis, and expanding blood vessels. Atractylodes macrocephala tastes bitter, sweet, warm in nature, dry dampness, diuresis, vasodilatation, and has inhibitory effects on epidermophyton flocculent and K. stellaria. The white peony is cool in nature, bitter in taste, has the effects of relieving pain, restraining yin and sweating, and has antibacterial effects. Pearl has the effects of astringent, skin-producing, ulcers not closing for a long time, and beautifying the skin. It can be absorbed by human epidermal cells, enhance cell viability, and promote metabolism. It also contains high-grade fatty alcohols, so it has a skin care effect. Therefore, pearl skin care products have the unique effect of preventing skin aging, and reasonable use can keep the skin soft and white, moisturized and smooth, and forever young and beautiful. Dry alum has the effect of genitalizing muscle, reducing water, and astringent. Peppermint can treat skin rubella, itching, measles impermeability and other symptoms. It is also effective for carbuncle, gangrene, scabies, ringworm, and varnish sores. The traditional Chinese medicine composition of the present invention uses Dendrobium nobile as the monarch medicine, Atractylodes rhizome and white peony as the minister medicine, pearl and dry alum as adjuvants, and peppermint as the remedy. All medicines are used in combination. , Antibacterial, antibacterial, astringent, muscle growth, and beautifying effects, so as to achieve the effect of removing acne.

The traditional Chinese medicine composition of the present invention is a pure traditional Chinese medicine formula, has significant curative effect on various pimples on the face, and has a wider treatment range than the prior art.

The experimental results show that the external use of the traditional Chinese medicine composition of the present invention has a cure rate of 58.75% in the treatment of acne, and the total effective rate is as high as 100%. Compared with topical tretinoin cream, the cure rate is increased by 46.25%, and the total effective rate is increased by 46.25%. Increase by 17.5%.

Attached drawings

Figure 1 is the effect picture of the patient's facial acne before use;

Figure 2 shows the effect of acne on the patient's face after 10 days of use.

Detailed ways

The present invention provides a traditional Chinese medicine composition with anti-acne function, comprising the following components by weight: 20-30 parts of Dendrobium nobile, 20-30 parts of Atractylodes macrocephala, 20-30 parts of white peony, 15-20 parts of pearl powder , 10-20 parts of alum and 5-10 parts of mint. In the present invention, the source of the raw materials of the traditional Chinese medicine is not particularly limited, and conventional commercial products can be used.

In the present invention, Dendrobium nobile is used as the monarch medicine, Atractylodes Rhizome and Radix Paeoniae Alba are the minister medicines, pearl and dried alum are used as adjuvants, and peppermint is used as the medicine. The combination of all medicines has the effects of clearing away heat and detoxification, promoting blood circulation, removing blood stasis, antibacterial and antibacterial, astringent muscle growth, and beautifying and beautifying, so as to achieve the effect of removing various pimples.

The present invention also provides a preparation method of the traditional Chinese medicine composition according to the above technical solution, which includes: mixing, pulverizing and irradiating the raw materials to sterilize the traditional Chinese medicine composition.

In the present invention, it is preferable to obtain a pulverized product after pulverizing the raw material, which is irradiated to sterilize the pulverized product, and the particle size of the pulverized product is less than or equal to 830 μm, more preferably 48 μm to 830 μm, and most preferably less than 48 μm. In the present invention, the raw material is pulverized and the particle size of the pulverized product is limited, and the obtained pulverized raw material is easier to prepare into a delicate paste, easy to be applied and applied to the face, and is more conducive to the utilization of effective ingredients.

In the present invention, the pulverized material is subjected to irradiation sterilization treatment to obtain an irradiated material. The irradiation dose of the irradiation sterilization is preferably 10-15 KGY, more preferably 13 KGY, and the irradiation sterilization time is preferably 13 -18 hours, more preferably 16 hours. In the present invention, the irradiation dose and time in the irradiation sterilization step have no obvious influence on the content and effect of the effective ingredients contained in the pulverized material, and can ensure that the pulverized material achieves the sterilization effect.

In the present invention, it is preferable that the traditional Chinese medicine composition is directly divided into 3g/package, or the traditional Chinese medicine composition is prepared into granules by a conventional preparation method and divided into 3g/package.

The present invention also provides the application of the traditional Chinese medicine composition described in the above technical scheme in the preparation of a medicament for removing acne on the face.

In the present invention, the method of using the traditional Chinese medicine composition is preferably: take 2-5g of the traditional Chinese medicine composition and add 20 mL of water, stir evenly, and apply directly on the face. After 20 minutes, it can be cleaned with clean water, once a day, Use 15-20 times continuously to cure various pimples.

The technical solutions provided by the present invention will be described in detail below in conjunction with the embodiments, but they should not be understood as limiting the protection scope of the present invention.

Example 1

Weigh 20 parts of Dendrobium nobile, 20 parts of Baizhu, 20 parts of white peony, 15 parts of pearl powder, 10 parts of alum, and 5 parts of mint. The dosage is 10KGY and the time is 13 hours, and the traditional Chinese medicine composition is obtained.

Example 2

Weigh 30 parts of Dendrobium nobile, 30 parts of Atractylodes rhizome, 30 parts of white peony, 20 parts of pearl powder, 20 parts of alum, and 10 parts of mint. The dosage is 15KGY and the time is 18 hours to obtain the traditional Chinese medicine composition.

Example 3

Weigh 25 parts of Dendrobium nobile, 25 parts of Atractylodes rhizome, 25 parts of white peony root, 18 parts of pearl powder, 15 parts of alum, and 8 parts of mint. The dosage is 13 KGY and the time is 16 hours to obtain the traditional Chinese medicine composition.

Example 4

160 cases of acne patients were selected as the research objects. All patients met the relevant clinical diagnostic criteria, and patients with intellectual disability and mental illness were excluded. All patients and their families had informed consent and signed an informed consent form. The patients were divided into observation group and control group by random number table method, each with 80 cases. The ratio of male to female in the observation group was 11:9, and the age was 16-23 years old, with an average of (18.5±2.2) years old; the ratio of male to female in the control group was 12:8, and the age was 17-25 years old, with an average of (18.6±2.3) years old. There was no statistically significant difference in the data of the two groups of patients (P>0.05), which met the requirements for comparison.

Control group: Apply tretinoin cream, 3 times/1 day, in the morning, midnight and evening, for 30 days, and observe the disappearance of facial acne.

Observation group: Take 3g of the traditional Chinese medicine composition prepared in Example 3, add 20mL of water, stir evenly, apply directly on the face, apply it for 20 minutes and then rinse with water, once a day, use 15-20 times continuously, observe the patient's face The disappearance of acne.

Efficacy evaluation criteria:

①Healed: Acne disappeared completely;

②Significant effect: the disappearance of acne>50%;

③Effective: 20%-50% of acne disappears;

④ Invalid: acne disappeared <20% or even worsened;

Total effective rate = recovery rate + apparent rate + effective rate.

Observation indicators:

Observe and record the disappearance of facial acne in all patients. The treatment results of the control group and the observation group are shown in Table 1.

Table 1 The treatment results of the control group and the observation group

It can be seen from Table 1 that the external use of the traditional Chinese medicine composition of the present invention has a cure rate of 58.75% in the treatment of acne, and the total effective rate is as high as 100%. Compared with topical tretinoin cream, the cure rate is increased by 46.25%. The efficiency is increased by 17.5%.

Case 1 Wang Mou, male, 24 years old, from Dongguan City, with pustular acne on his face. The course of the disease is 3 years. In May 2019, he used Example 3 of the Chinese medicine composition of the present invention. Add 3 g of the Chinese medicine composition and add 20 mL of water, and stir evenly. Apply directly to the face, wash it off with water after 20 minutes of application, once a day for 18 times, the patient's facial acne basically disappeared.

Case 2 Chen, male, 18 years old, from Dongguan City, with pustule-like acne on his face. The course of the disease was 2 years. In July 2019, he used the traditional Chinese medicine composition Example 1 of the present invention, and added 3 g of the traditional Chinese medicine composition to 20 mL of water, and stirred evenly. Apply directly to the face, wash it off with water after 20 minutes of application, once a day for 15 times, the patient's facial acne basically disappeared (Figure 1).

Case 3 Li, female, 24 years old, from Changsha City, with pustular acne on her face, with a course of 3.5 years, using the traditional Chinese medicine composition Example 3 of the present invention in March 2019, adding 3 g of the traditional Chinese medicine composition to 20 mL of water, and stirring evenly. Apply it directly on the face, wash it off with water after applying it for 20 minutes, once a day, and use it continuously for 20 times. The pimples on the patient's face have basically disappeared (Figure 2).

The above are only the preferred embodiments of the present invention. It should be pointed out that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and modifications can be made, and these improvements and modifications are also It should be regarded as the protection scope of the present invention.

Claims

A traditional Chinese medicine composition with anti-acne function, characterized in that it comprises the following components in parts by weight: 20-30 parts of Dendrobium nobile, 20-30 parts of Atractylodes macrocephala, 20-30 parts of white peony, 15-20 parts of pearl powder , 10-20 parts of alum and 5-10 parts of mint.
The preparation method of the traditional Chinese medicine composition according to claim 1, characterized in that it comprises: mixing the raw materials, pulverizing and irradiating sterilization to obtain the traditional Chinese medicine composition.
The preparation method according to claim 2, wherein the pulverized product is obtained after the raw material is pulverized, and the pulverized product is sterilized by irradiation, and the particle size of the pulverized product is less than or equal to 830 μm.
The preparation method according to claim 3, wherein the particle size of the pulverized product is 48 μm-830 μm.
The preparation method according to claim 3, wherein the particle size of the pulverized product is less than 48 μm.
The preparation method according to claim 2, wherein the irradiation dose of the irradiation sterilization is 10-15 KGY, and the time of the irradiation sterilization is 13-18h.
The preparation method according to claim 6, wherein the irradiation dose of the irradiation sterilization is 13KGY, and the time of the irradiation sterilization is 16h.
The use of the traditional Chinese medicine composition according to claim 1 in the preparation of a medicament for removing acne on the face.