CN1304042C - Production of externally-applied for treating acne - Google Patents

Abstract

The present invention relates to a production method of an externally-applied medicine for treating acne. The externally-applied medicine comprises the components of fresh green bristlegrass herbs, fresh shave grasses, fresh peristrophe japonica, fresh faber bauhinia branchlets or roots, fresh camphor tree leaves, fresh peppermint, fresh wild chrysanthemum flowers, borneol and ethanol with the concentration of 75%. The medicine of the present invention can be applied outside an affected part. The externally-applied medicine of the present invention has the advantages of good therapeutic effect on treating acne (whelk), quick medicinal effect (the medicine can take effect in one day), short course of treatment (the treatment time is seven days on average), low recurrence rate after curing, convenient use, no toxic or side effect, extensive and easy available medicinal herb resource, simple production technology, low price, low production cost and capability of long-stem storage. The externally-applied medicine has two innovation points that (1) the raw materials are all fresh medicines, and thus, the effect of the medicines are strong; (2) the medicines are compounded in view of the causes and the disease mechanism of acne, the effect of the medicines is rapid and obvious, the acne can be cured thoroughly, and no scar is left. As proved by 300 cases of clinical application, the cure rate of the externally-applied medicine is 88.7%, the effective rate is 96.3%, an obvious effect can be obtained by applying the medicine for one day, and the acne can be cured in seven days. The externally-applied medicine of the present invention is suitable for patients with common acne of various types to use.

Description

A kind of manufacture method for the treatment of the medicine for external use of acne

Technical field

The present invention relates to a kind of manufacture method of external used medicine, particularly a kind of various acne at face, the energy heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, inducing resuscitationization is turbid, the manufacture method of the medicine for external use of the treatment acne of expelling pus and promoting granulation.

Background technology

Acne claims acne, skin sore, whelk again, is the chronic pilosebaceous unit inflammation of a kind of obstructive multifactor, the pleomorphism erythra, is the common a kind of dermatosis of adolescence.Clinically remedy of acne mainly is to use retinoid compounds such as Accutane, antiandrogen class medicine such as spironolactone, or adopting antibiotic, erythromycin, tetracycline etc., local treatment mainly is to adopt the sulfur frost of external, sulfur lotion, skin sore water etc.The weak point of above-mentioned various Therapeutic Method is that treatment time is long, and side effect is arranged, the curative effect instability, and inconvenience is used in easily recurrence, and high-leveled and difficult the getting of medicine source valency, complex manufacturing technology, production cost height.

Summary of the invention

The purpose of this invention is to provide a kind of various acne at face, the energy heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, inducing resuscitationization is turbid, the manufacture method of the medicine for external use of the treatment acne of expelling pus and promoting granulation.

The present invention is based on motherland's medical science the pathogenetic research and the Therapeutic Principle of acne is put forward.Medicine of the present invention is a Chinese herbal compound preparation, and the anti-inflammation function that tool is very strong suppresses smegma, anti-sebaceous gland glandular tube keratinization, dissolution angular embolization is removed old keratinization matter, dispels the skin dirt, a mediation hair key is repaired the skin that has damaged, eliminates because of the pitchy cicatrix due to the acne.Herba Setariae Viridis in its prescription, Herba Equiseti Hiemalis, Herba Peristrophes, Herba Dendranthematis indici, heat-clearing and toxic substances removing, parasite killing antiphlogistic antibacterial; Folium cinnamomi camphorae contains Camphora (" Chinese medicine sea ": Camphora is that root, stem, branch, the leaf of canella Camphor tree made through refinement) Cinnamormuin oamphoral Presl, property is hot, the sensible dissipating blood stasis of energy, detumescence, it is turbid to join having one's ideas straightened out, the Borneolum Syntheticum of tonneau heat clearing away, an one cold heat, bring out the best in each other, the antiinflammatory sterilization, the power of promoting tissue regeneration and ulcer healing is stronger.The Herba Menthae fresh leaf contains volatile oil 08%-1%, and main component is menthol (Menthol) in the oil, and stronger antibacterial action is arranged, and the Cold receptor of the tip that can excite nerve and produce cool sense.Ramulus et Folium Bauhiniae Faberi, hard masses softening and resolving, clear and rich yin fluid astringing is joined the Herba Equiseti Hiemalis of removing heat from blood and promoting blood circulation, and the Borneolum Syntheticum of sensible granulation promoting is joined the logical hair of an a surname key again, and through sick the content of priming is 75% ethanol, can remove acne nodule, cyst, dark brown spot.All medicines share, the heat-clearing and toxic substances removing of building together, and removing heat from blood and promoting blood circulation, inducing resuscitationization is turbid, the effect of expelling pus and promoting granulation.

Technical scheme of the present invention is: a kind of manufacture method for the treatment of the medicine for external use of acne, its medicine is made by the following weight proportion raw material: bright Herba Setariae Viridis 10-12 part, bright Herba Equiseti Hiemalis 8-10 part, bright Herba Peristrophes 8-10 part, bright Ramulus et Folium Bauhiniae Faberi 8-10 part, bright Folium cinnamomi camphorae 8-11 part, bright Herba Menthae 4-8 part, bright Herba Dendranthematis indici 6-12 part, Borneolum Syntheticum 0.5-5 part, 75% ethanol 30-120 part.

Optimum weight proportioning of the present invention is: 8 parts of bright Herba Setariae Viridis, 8 parts of bright Herba Equiseties Hiemalis, 8 parts of bright Herba Peristrophess, 8 parts of bright Ramulus et Folium Bauhiniae Faberi, 8 parts of bright Folium cinnamomi camphorae, 6 parts of bright Herba Menthaes, 8 parts in bright Herba Dendranthematis indici, 0.8 part of Borneolum Syntheticum, 110 parts of 75% ethanol.

Manufacture method: the fresh Chinese herbal medicine material that will gather is cleaned, and dries water, packs in the clean disinfectant container by proportioning, and adding content by proportioning is 75% ethanol, sealing was soaked 15-30 days, leached medicinal residues, in solution by proportioning adding Borneolum Syntheticum.

During use, put the affected part outward on the skin with medicine of the present invention and get final product.

Medicine among the present invention: Herba Setariae Viridis, the beginning is stated from Compendium of Material Medica, and lightly seasoned cool in nature for the herb of the plant Herba Setariae Viridis Setaria viridis of standing grain section (L) Beauv, its effect is a removing toxic substances and promoting subsidence of swelling, controls the carbuncle pyogenic infections from tumour or sore, impetigo, pustules (Chinese medicine sea); The Herba Equiseti Hiemalis, the beginning is stated from the 《 Jiayou Bencao ", be the herb of Equisetaceae plant Herba Equiseti Hiemalis Equisetum hiemale L., sweet in the mouth, hardship, property is put down, and its effect is the diaphoresis expelling pathogenic factors from muscles, rises the fire stagnation Compendium of Material Medica of loosing, control carbuncle, treat poison, furuncle and phyma, tinea versicolor, granulated slag " beautiful Chinese catalpa medicine is separated ", removing heat from blood and promoting blood circulation hemostasis " Chinese medicine sea "; Herba Peristrophes, beginning is stated from " Zhiwu Mingshi Tukao ", herb for acanthaceous plant Herba Peristrophes Peristrophe.japonica (Thunb.) Brem, acrid in the mouth is cool in nature, its effect is a removing toxicity for eliminating carbuncles, stem and leaf is mashed coating and is controlled black bleb furuncle " Chinese medicine sea ", controls pneumonia, swelling throat carbuncle " Fujian Chinese herbal medicine "; Ramulus et Folium Bauhiniae Faberi, the beginning is stated from " Guangxi Chinese medicinal herbal ", is the branch and leaf of leguminous plant saddle leaf Bauhinia purpurea Bauhinia faberi oliv, bitter in the mouth, puckery, property is flat, and its effect is the dehumidifying parasite killing, hard masses softening and resolving, clearing heat and moistening lung, yin fluid astringing is calmed the nerves, control eczema, scabies, scrofula, cough due to lung-heat, palpitation and insomnia, the night sweat seminal emission; Folium cinnamomi camphorae, the beginning is stated from supplementary Amplifications of the Compendium of Materia Medica, is the leaf of canella Camphor tree Cinnamomum camphora (L.), bitter in the mouth, suffering, warm in nature, its effect is an expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, killing parasites for relieving itching, dispelling the wind and dampness pathogens osteodynia, traumatic injury, swelling and pain due to blood stasis, scabies, beriberi infection, fungal infection of hand and foot, ancylostomes etc. " Chinese medicine sea " are controlled carbuncle of yin nature " Quanzhou book on Chinese herbal medicine "; Herba Menthae, the beginning is stated from Tang Materia Medica, is the stem and leaf of labiate Herba Menthae Mntha haplocalyx Briq., acrid in the mouth, cool in nature, its effect is a clearing away heat and expelling pathogen in the exterior, the clear sharp head, dispersing the stagnated live-QI to relieve the stagnation of QI is controlled affection due to external wind and heat, headache, throat pain is for controlling scrofula, the key medicine Compendium of Material Medica of skin ulcer scabies, interior flesh bone reaches the flesh table outward, run through meridians, kind disinfection bacterium " Records of Tradition Chinese and Western Medicine in Combination "; Herba Dendranthematis indici, beginning is stated from " Japan hanako materia medica ", be the herb of feverfew Chrysanthemum indicum L., acrid in the mouth, hardship, cold in nature, heat-clearing and toxic substances removing, the carbuncle furuncle is controlled in the damp eliminating evacuation of pus, all innominate toxic swellings " Chinese medicine sea ", the not broken person of carbuncle swelling smashes juice clothes, slag external application " Ruizhutang Jingyan Fang, Empirical Recipes from Auspicious Bamboo Hall "; Borneolum Syntheticum, the beginning is stated from " Newly Revised Canon of Materia Medica ", is the process of resin product of Dipterocarpaceae plant Borneolum Syntheticum Borneolam Syntheticum, also can be chemical method synthetic (BORNEOLUM SYNTHETICUM), acrid in the mouth, hardship, cool in nature, effect is that causing resuscitation with aromatic drugsization is turbid, and tonneau is jammed, and bar reaches meridians, heat-clearing and toxic substances removing, parasite killing detumescence, promoting tissue regeneration and ulcer healing, control apoplexy, syncope due to accumulation of phlegm, the card of coma due to the hyperpyrexia, control the skin infection carbuncle, the key medicine of laryngopharynx swelling and pain " Chinese medicine sea "; Ethanol, the infiltration sterilization, content is 75% ethanol sterilization, penetration is the strongest.Behind prescription, make them produce good synergism, reach the effect of treatment acne.

Medicine of the present invention is good to acne (comedo) therapeutic effect, and drug effect is (1 day takes effect) rapidly, short treating period (7 days mean treatment time), and relapse rate is low, easy to use after curing, and has no side effect.Extensively easily get in the medicine source, and processing technology is simple, cheap, and production cost is low, can long preservation.Its innovation part has two: one, the bright medicine side of going into, and the efficacy of a drug is grander; Two, at the cause of disease and the pathogenesis prescription of acne, drug effect is distinguished rapidly, thorough treatment, preventing from scar.Through clinical practice 300 examples, cure rate is 88.7%, and effective percentage is 96.3%, and the obvious effect of medication 1 daybreak was cured in 7 days, is applicable to that the acne vulgaris patient of various disease types uses.

Subordinate list: clinical application effect statistical table

	The 3rd day	The 7th day
			Total case load is cured effectively efficient invalid inefficiency of cure rate produce effects obvious effective rate	300 105 35％ 225 75％ 289 96.3％ 11 3.7％	300 266 88.7％ 286 95.7％ 289 96.3％ 11 3.7％

Model case

Example one Lee * *, man, 21 years old, Qidong County, Hunan buyun bridge town store clerk.Because of facial, chest and back erythra 2 years, the aggravation first quarter moon came to go to a doctor on June 17th, 1997.The patient began to occur erythra from face over 2 years, increased gradually, and developed into chest and back, bought anti-inflammatory ointment and the external of acne equality medicine by oneself, imitated not good.Look into: more intensive pimple is seen at forehead, two cheekbones, breast, back, and part is the pus point, examines to be pustule acne.Put on the skin outward with medicine of the present invention, days 6 times, put on the skin repeatedly 6 times at every turn, advise avoid drink, delicious food savoury, pungent barbecue dryness-fire food, advise medication further consultation after 3 days.Further consultation on June 20 in the same year, effect was fine after the patient told medication.Look into: the pimple at former position reduces, and pustular eruption is formed a scab.Continue to put on the skin outward with medicine of the present invention.24 days three June of the same year examines, and facial, chest and back pimple disappears fully, and crust comes off, and skin is as before bright and clean.After the healing, follow up a case by regular visits to and do not have recurrence in 2 years.

Example is two old *, woman, 16 years old, six middle school student of Hengyang City, Hunan.Facial rash was aggravated February in 2 years, came to go to a doctor on May 21st, 1999.The patient began forehead and erythra occurs before 2 years, develop into buccal portion, nose both sides gradually, and menstrual phase increases the weight of, and failed to respond to any medical treatment in many places.Look into: volume, face are seen grain of rice size pimple, and the part pimple is identical with the colour of skin, and part is a pale red, does not have conscious discomfort, and other position of whole body does not have similar erythra.Examine and be the papular type acne.Put the affected part outward on the skin with medicine of the present invention, day 6 times, put on the skin repeatedly 6 times at every turn.Advise avoid drink, delicious food savoury, pungent barbecue dryness-fire food.Further consultation on May 26 in the same year, erythra disappears basically, cures.The patient tells, and medication promptly obviously took effect in one day.Advise and continue to put on the skin outward 3 days, as a means of consolidation with medicine of the present invention.Follow up a case by regular visits to and do not have recurrence in 3 years.

Example three wears * *, man, 28 years old, the worker of University Of Nanhua.Nearly 10 years of facial rash is aggravated February.Go to a doctor on October 29th, 2004.About 10 years of private prosecution facial rash, outbreak aggravation repeatedly.Examine through how tame large hospital department of dermatologry and to be acne (capsule), several times for oral administration, external medication is deceived and is imitated.Look into: volume, buccal, chest and back are all seen pimple, take on a red color, and kermesinus, part pimple have the pus point.Big pimple is the cyst shape, pressure fluctuation arranged.Examine and be acne cystica.Put on the skin outward with medicine of the present invention and to put on the skin 6-7 time every day, put on the skin 6-7 time at every turn.Advise avoid drink, delicious food savoury, pungent barbecue dryness-fire food.Further consultation on November 5 in the same year.Big effect is told in patient's happiness.Require to continue to put on the skin outward with medicine of the present invention.Look into: volume, buccal, chest and back erythra major part disappear, and buccal portion cyst is before dwindled, the calm innervation of pressure, produce effects.Advise and continue to put on the skin outward with medicine of the present invention, usage is the same.12 days three November of the same year examines, and sees that erythra disappears fully, and only former cyst position skin color is brown.Advise its continuation to put on the skin outward,, follow up a case by regular visits to scheme the brown macules that disappears with medicine of the present invention.

Claims (2)

1, a kind of manufacture method for the treatment of the medicine for external use of acne is characterized in that what it was made by the following weight proportion raw material: bright Herba Setariae Viridis 10-12 part, bright Herba Equiseti Hiemalis 8-10 part, bright Herba Peristrophes 8-10 part, bright Ramulus et Folium Bauhiniae Faberi 8-10 part, bright Folium cinnamomi camphorae 8-11 part, bright Herba Menthae 4-8 part, bright Herba Dendranthematis indici 6-12 part, Borneolum Syntheticum 0.5-5 part, 75% ethanol 30-120 part; Its manufacture method is: the fresh Chinese herbal medicine material that will gather is cleaned, and dries water, packs in the clean disinfectant container by proportioning, and adding content by proportioning is 75% ethanol, sealing was soaked 15-30 days, leached medicinal residues, in solution by proportioning adding Borneolum Syntheticum.

2, a kind of manufacture method for the treatment of the medicine for external use of acne according to claim 1 is characterized in that what it was made by the following weight proportion raw material: 8 parts of bright Herba Setariae Viridis, 8 parts of bright Herba Equiseties Hiemalis, 8 parts of bright Herba Peristrophess, 8 parts of bright Ramulus et Folium Bauhiniae Faberi, 8 parts of bright Folium cinnamomi camphorae, 6 parts of bright Herba Menthaes, 8 parts in bright Herba Dendranthematis indici, 0.8 part of Borneolum Syntheticum, 110 parts of 75% ethanol.