CN112057555B - A composition for treating keratotic skin diseases and its preparation method - Google Patents
A composition for treating keratotic skin diseases and its preparation method Download PDFInfo
- Publication number
- CN112057555B CN112057555B CN202011030517.7A CN202011030517A CN112057555B CN 112057555 B CN112057555 B CN 112057555B CN 202011030517 A CN202011030517 A CN 202011030517A CN 112057555 B CN112057555 B CN 112057555B
- Authority
- CN
- China
- Prior art keywords
- parts
- composition
- skin
- radix
- cortex dictamni
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 208000017520 skin disease Diseases 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 17
- 240000000759 Lepidium meyenii Species 0.000 claims abstract description 17
- 235000000421 Lepidium meyenii Nutrition 0.000 claims abstract description 17
- 235000012902 lepidium meyenii Nutrition 0.000 claims abstract description 17
- 239000000284 extract Substances 0.000 claims abstract description 16
- 241001313857 Bletilla striata Species 0.000 claims abstract description 15
- 239000002674 ointment Substances 0.000 claims abstract description 13
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940116229 borneol Drugs 0.000 claims abstract description 12
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 12
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 12
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 10
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 10
- 235000008282 Sanguisorba officinalis Nutrition 0.000 claims abstract description 10
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 9
- 241000123069 Ocyurus chrysurus Species 0.000 claims abstract description 9
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 235000008291 Poterium sanguisorba Nutrition 0.000 claims abstract description 5
- 240000001341 Reynoutria japonica Species 0.000 claims abstract description 5
- 235000018167 Reynoutria japonica Nutrition 0.000 claims abstract description 5
- 241000218158 Clematis Species 0.000 claims abstract description 4
- 244000061520 Angelica archangelica Species 0.000 claims abstract 3
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract 3
- 239000003871 white petrolatum Substances 0.000 claims description 17
- 235000008216 herbs Nutrition 0.000 claims description 12
- 241000903946 Clematidis Species 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 9
- 241000915604 Scutellaria barbata Species 0.000 claims description 8
- 238000007873 sieving Methods 0.000 claims description 8
- 238000002844 melting Methods 0.000 claims description 7
- 230000008018 melting Effects 0.000 claims description 7
- 238000011282 treatment Methods 0.000 claims description 6
- 244000173853 Sanguisorba officinalis Species 0.000 claims description 5
- 210000003298 dental enamel Anatomy 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 241001289529 Fallopia multiflora Species 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 24
- 239000003814 drug Substances 0.000 abstract description 20
- 239000008280 blood Substances 0.000 abstract description 16
- 210000004369 blood Anatomy 0.000 abstract description 16
- 206010040882 skin lesion Diseases 0.000 abstract description 13
- 231100000444 skin lesion Toxicity 0.000 abstract description 13
- 208000003251 Pruritus Diseases 0.000 abstract description 10
- 206010020649 Hyperkeratosis Diseases 0.000 abstract description 9
- 230000003213 activating effect Effects 0.000 abstract description 7
- 230000001737 promoting effect Effects 0.000 abstract description 7
- 208000001126 Keratosis Diseases 0.000 abstract description 6
- 230000035876 healing Effects 0.000 abstract description 6
- 230000007803 itching Effects 0.000 abstract description 6
- 206010048218 Xeroderma Diseases 0.000 abstract description 3
- 206010021198 ichthyosis Diseases 0.000 abstract description 3
- 230000008338 local blood flow Effects 0.000 abstract description 3
- 239000011159 matrix material Substances 0.000 abstract description 3
- 230000000474 nursing effect Effects 0.000 abstract description 3
- 229940126673 western medicines Drugs 0.000 abstract description 3
- 238000009776 industrial production Methods 0.000 abstract description 2
- 239000000419 plant extract Substances 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- 240000004064 Poterium sanguisorba Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 13
- 206010040844 Skin exfoliation Diseases 0.000 description 12
- 230000035618 desquamation Effects 0.000 description 12
- 238000003745 diagnosis Methods 0.000 description 7
- 235000019640 taste Nutrition 0.000 description 7
- 241000125175 Angelica Species 0.000 description 6
- 244000132619 red sage Species 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- 241001313855 Bletilla Species 0.000 description 4
- 241000581682 Sanguisorba Species 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 208000026935 allergic disease Diseases 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 230000006003 cornification Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000017423 tissue regeneration Effects 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 206010013700 Drug hypersensitivity Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 235000019606 astringent taste Nutrition 0.000 description 2
- 230000001143 conditioned effect Effects 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 201000005311 drug allergy Diseases 0.000 description 2
- 210000003811 finger Anatomy 0.000 description 2
- 210000004247 hand Anatomy 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000003780 keratinization Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000037380 skin damage Effects 0.000 description 2
- 235000021259 spicy food Nutrition 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000009897 systematic effect Effects 0.000 description 2
- 210000003813 thumb Anatomy 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000213006 Angelica dahurica Species 0.000 description 1
- 241000219193 Brassicaceae Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000004035 construction material Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 210000005224 forefinger Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000001329 hyperkeratotic effect Effects 0.000 description 1
- 230000001969 hypertrophic effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 235000005412 red sage Nutrition 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of skin diseases, in particular to a composition for treating keratotic skin diseases and a preparation method thereof, wherein the composition is prepared from the following raw materials in parts by weight: 4000-6000 parts of albolene, 100-120 parts of raw angelica, 100-120 parts of salvia miltiorrhiza, 60-80 parts of prepared fleece-flower root, 100-120 parts of cassia twig, 60-80 parts of raw garden burnet, 60-80 parts of clematis root, 60-80 parts of madder, 60-80 parts of sculellaria barbata, 40-60 parts of bletilla striata, 40-60 parts of cortex dictamni, 10-20 parts of borneol and 4-6 parts of maca extract, and the matrix is effectively combined with the medicaments, so that the ointment has the effects of moistening skin, detoxifying, nourishing blood, activating blood, dispelling wind, relieving itching, moistening skin, improving local blood circulation of skin lesions, promoting quick healing of dry, chapped and keratinized skin, and is safe and stable in components, free of side effects and dependence of western medicines, exact in curative effect and convenient to apply, store and carry; can treat keratoderma, also can improve xeroderma symptoms by daily nursing, is suitable for both children and adults, and has wide application; the traditional Chinese medicine and the plant extract are adopted, so that the preparation is simple, the industrial production is convenient, and the clinical and life popularization is easy.
Description
Technical Field
The invention relates to the technical field of skin diseases, in particular to a composition for treating keratotic skin diseases and a preparation method thereof.
Background
The society develops rapidly, and the daily diet is complicated, and skin care products are conventional, and life exposure chemical diversification, and operational environment specialization lead to the hyperkeratotic skin disease and frequently rise. For example, when the lipstick is not used properly, the lip is chapped and cornified; the hand keratosis and the hand chap are caused by special work, frequent hand disinfection stimulation in medical care, contact of construction workers with construction materials such as cement and the like; social aging, specific age of the elderly, physiological reduction of oil secretion in the skin of hands and feet, dryness, chapping and high hair of hands and feet and body, and the like. The therapeutic care of such diseases is becoming an increasingly important part of the clinical dermatology.
The ointment mainly comprises western medicine hormone ointment and cornification-inhibiting ointment, has the defects of dependence, easy relapse, intolerance to the old and children, incapability of being repeatedly used for a long time, incapability of being used by medical care and the like. The traditional Chinese medicine treatment is mainly implemented by using herbal medicines, the decoction is washed outside, the dosage forms are few, the influence of the environmental temperature is large, the use is inconvenient, the long-term medication compliance is poor, the effect is general, and the traditional Chinese medicine cannot be used as the optimal selection for long-term treatment and nursing of all ages. The traditional Chinese medicine ointment for treating keratosis hypertrophic dermatosis in the existing medical market is very few, hormone or keratinization-inhibiting western medicine components are added, the stability is poor, and the curative effect is not exact. Daily skin care products such as vitamin E milk and the like have good effects of daily skin care and skin moistening, but have uncertain effects of keratinization inhibition, chap healing and relapse prevention.
Disclosure of Invention
In order to solve the technical problems, the invention provides a preparation method of a composition for treating keratotic skin diseases, which has good effect, prevents relapse, has no side effect and dependence of western medicines, is a pure plant component preparation, is safe and stable, has definite curative effect, is convenient to apply, store and carry, can treat keratotic skin diseases, can also be used for daily nursing and improving xeroderma symptoms, is suitable for people of all ages, and has wide application.
In order to realize the purpose, the invention is realized by adopting the following technical scheme:
a composition for treating keratotic skin diseases is prepared from the following raw materials in parts by weight: 4000-6000 parts of white vaseline, 100-120 parts of raw angelica, 100-120 parts of salvia miltiorrhiza, 60-80 parts of prepared fleece-flower root, 60-80 parts of cassia twig, 60-80 parts of raw garden burnet root, 60-80 parts of clematis root, 60-80 parts of madder, 60-80 parts of barbed skullcap herb, 40-60 parts of bletilla striata, 40-60 parts of cortex dictamni, 10-20 parts of borneol and 4-6 parts of maca extract.
In one possible technical scheme, the composition is prepared from the following raw materials in parts by weight: 5000 parts of white vaseline, 110 parts of raw angelica, 110 parts of salvia miltiorrhiza, 70 parts of prepared polygonum multiflorum, 70 parts of cassia twig, 70 parts of raw sanguisorba, 70 parts of radix clematidis, 70 parts of madder, 70 parts of barbed skullcap herb, 50 parts of bletilla striata, 50 parts of cortex dictamni, 15 parts of borneol and 5 parts of maca extract.
In one possible embodiment, the composition is prepared as a paste.
A method for preparing a composition for treating keratotic skin disorders, comprising the steps of:
1) melting white vaseline in an enamel basin until the white vaseline is boiled;
2) adding radix Angelicae sinensis, Saviae Miltiorrhizae radix, radix Polygoni Multiflori Preparata, ramulus Cinnamomi, radix Sangusorbae, radix Clematidis, radix Rubiae, and herba Scutellariae Barbatae at a certain weight ratio, continuously frying for 20-30 min until the herbs are all brown, sieving to remove brown herbs, adding extracts of rhizoma Bletillae, cortex Dictamni Radicis and Lepidium Meyenii Walp, stirring, and standing;
3) standing to 40-50 deg.C, adding Borneolum Syntheticum, stirring, cooling to solidify, and making into unguent.
In one possible technical solution, the melting temperature in the step 1) is 100-.
In a possible technical scheme, the sieving in the step 2) is a 50-mesh sieving.
In one possible technical scheme, the bletilla striata and the cortex dictamni are wall-broken bletilla striata powder and cortex dictamni powder respectively.
Compared with the prior art, the invention has the beneficial effects that: after the white vaseline is fried in the herbs, the substrate is effectively combined with the medicines, so that the skin moistening and detoxifying, the blood nourishing and activating, the wind dispelling and itching relieving effects are achieved, the skin is moistened and nourished, the local blood circulation of skin lesions is improved, the physiological function of the skin is conditioned, and the pathological state of the skin lesions is changed; after the cortex dictamni, the bletilla striata, the maca extract and the borneol are added, the wind-evil dispelling, the pain relieving, the astringency and the tissue regeneration promoting effects are achieved, and the rapid healing of dry chapped and keratinized skin is promoted; the ointment of the pure traditional Chinese medicine composition preparation is safe and stable, has no side effect and dependence of western medicines, has definite curative effect, and is convenient to apply, store and carry; can be used for treating keratoderma, and improving xeroderma by daily care, and is suitable for people of all ages and has wide application. The preparation method adopts genuine Chinese medicines and plant extracts, is simple to prepare, is convenient for industrial production, and is easy for clinical and life popularization.
Detailed Description
The following examples are given to further illustrate the embodiments of the present invention. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1
A composition for treating keratotic skin diseases is prepared from the following raw materials in parts by weight: 4000 parts of white vaseline, 100 parts of raw angelica, 100 parts of salvia miltiorrhiza, 60 parts of prepared polygonum multiflorum, 60 parts of cassia twig, 60 parts of raw sanguisorba, 60 parts of radix clematidis, 60 parts of madder, 60 parts of barbed skullcap herb, 40 parts of bletilla striata, 40 parts of cortex dictamni, 10 parts of borneol and 4 parts of maca extract.
The preparation method of the composition comprises the following steps:
1) melting white vaseline in an enamel basin at 100 ℃ until boiling;
2) adding radix Angelicae sinensis, Saviae Miltiorrhizae radix, radix Polygoni Multiflori Preparata, ramulus Cinnamomi, radix Sangusorbae, radix Clematidis, radix Rubiae, and herba Scutellariae Barbatae at a certain weight ratio, continuously frying for 20 min until the herbs are all brown, sieving with 50 mesh sieve to remove brown herbs, adding wall-broken rhizoma bletilla powder, cortex Dictamni Radicis powder and Lepidium Meyenii Walp extract, stirring, and standing;
3) standing to 40 deg.C, adding Borneolum Syntheticum, stirring, cooling to solidify, and making into unguent.
The invention discloses a brief introduction of the efficacy of each traditional Chinese medicine:
the angelica is sweet and pungent in taste and warm in nature, and has the effects of enriching and activating blood, regulating menstruation and relieving pain, and relaxing bowel;
the salvia miltiorrhiza is bitter in taste and slightly cold, and has the effects of activating blood circulation to dissipate blood stasis, stimulating the menstrual flow to relieve pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle;
radix Polygoni Multiflori Preparata, bitter, sweet, astringent, warm; has effects in nourishing liver and kidney, nourishing blood and essence, blackening hair and beard, and strengthening muscle and bone;
cassia twig, pungent and sweet in flavor and warm in nature, has the effects of inducing sweat, relieving exterior syndrome, dispelling cold, relieving pain, activating yang and regulating qi;
the raw garden burnet is bitter, sour, astringent and slightly cold, and has the effects of cooling blood, stopping bleeding, detoxifying and healing sore;
the clematis root is pungent, salty and warm in nature, and has the effects of expelling wind-damp and dredging channels and collaterals;
radix Rubiae, bitter in taste and cold in nature, has effects of cooling blood, stopping bleeding, promoting blood circulation and removing blood stasis;
the sculellaria barbata is cold in nature and sour in taste, and has the functions of clearing heat and removing toxicity, activating blood and removing stasis, relieving swelling and pain, resisting cancer and the like;
bletilla striata, slightly cold in nature, bitter, sweet and astringent in taste, has the effects of astringing to stop bleeding, reducing swelling and promoting tissue regeneration;
the cortex dictamni is bitter in taste and cold in nature, and has the effects of clearing heat, drying dampness, dispelling wind and removing toxicity;
borneol is pungent and cool in taste, and has the effects of inducing resuscitation, refreshing mind, clearing heat, removing toxicity, improving eyesight and removing nebula;
maca, which is a plant belonging to genus S.C.of family Brassicaceae, has comprehensive and balanced nutritional ingredients and unique active substances, and can effectively strengthen immune system and improve sub-health state;
white vaseline in the formula is used as a matrix, is safe and stable, has a good skin moistening effect, can be organically combined with the traditional Chinese medicine, and fully exerts the curative effects of the traditional Chinese medicine and the matrix; cortex dictamni and radix clematidis: dispelling wind and eliminating dampness and dredging collaterals, clearing heat and removing toxicity, killing insects, improving local environment of skin damage and preventing infection, wherein the Chinese angelica, the cassia twig, the red sage root, the prepared fleece-flower root and the maca extracts: enriching blood, nourishing blood, moistening skin, promoting blood circulation for removing blood stasis, improving local circulation, and restoring skin function; madder, barbed skullcap herb: removing toxic substance, cooling blood and promoting blood circulation; raw garden burnet root and bletilla striata: astringe, promote granulation and detumescence, promote wound healing; borneol: clearing heat, relieving pain and treating sore; after the white vaseline is fried in the herbs, the substrate is effectively combined with the medicines, so that the skin moistening and detoxifying, the blood nourishing and activating, the wind dispelling and itching relieving effects are achieved, the skin is moistened and nourished, the local blood circulation of skin lesions is improved, the physiological function of the skin is conditioned, and the pathological state of the skin lesions is changed; after the cortex dictamni, the bletilla striata, the maca extract and the borneol are added, the wind-evil dispelling, the pain relieving, the astringency and the tissue regeneration promoting effects are achieved, and the rapid healing of dry chapped and keratinized skin is promoted; the finished ointment has safe and stable components and can be applied to medical and daily care.
Example 2
A composition for treating keratotic skin diseases is prepared from the following raw materials in parts by weight: 5000 parts of white vaseline, 110 parts of raw angelica, 110 parts of salvia miltiorrhiza, 70 parts of prepared polygonum multiflorum, 70 parts of cassia twig, 70 parts of raw sanguisorba, 70 parts of radix clematidis, 70 parts of madder, 70 parts of barbed skullcap herb, 50 parts of bletilla striata, 50 parts of cortex dictamni, 15 parts of borneol and 5 parts of maca extract.
The preparation method of the composition comprises the following steps:
1) melting white vaseline in an enamel basin at 110 ℃ until boiling;
2) adding radix Angelicae sinensis, Saviae Miltiorrhizae radix, radix Polygoni Multiflori Preparata, ramulus Cinnamomi, radix Sangusorbae, radix Clematidis, radix Rubiae, and herba Scutellariae Barbatae at a certain weight ratio, continuously frying for 25 min until the herbs are all brown, sieving with 50 mesh sieve to remove brown herbs, adding wall-broken rhizoma bletilla powder, cortex Dictamni Radicis powder and Lepidium Meyenii Walp extract, stirring, and standing;
3) standing to 45 deg.C, adding Borneolum Syntheticum, stirring, cooling to solidify, and making into unguent.
Example 3
A composition for treating keratotic skin diseases is prepared from the following raw materials in parts by weight: 6000 parts of white vaseline, 120 parts of raw angelica, 120 parts of salvia miltiorrhiza, 80 parts of prepared fleece-flower root, 80 parts of cassia twig, 80 parts of raw sanguisorba, 80 parts of radix clematidis, 80 parts of madder, 80 parts of barbed skullcap herb, 60 parts of bletilla, 60 parts of cortex dictamni, 20 parts of borneol and 6 parts of maca extract.
The preparation method of the composition comprises the following steps:
1) melting white vaseline in an enamel basin at 120 ℃ until boiling;
2) adding radix Angelicae sinensis, Saviae Miltiorrhizae radix, radix Polygoni Multiflori Preparata, ramulus Cinnamomi, radix Sangusorbae, radix Clematidis, radix Rubiae, and herba Scutellariae Barbatae at a certain weight ratio, continuously frying for 30 min until the herbs are all brown, sieving with 50 mesh sieve to remove brown herbs, adding wall-broken rhizoma bletilla powder, cortex Dictamni Radicis powder and Lepidium Meyenii Walp extract, stirring, and standing;
3) standing to 50 deg.C, adding Borneolum Syntheticum, stirring, cooling to solidify, and making into unguent.
Cases of disease
Patients 1, Wu-Chi, women, 25 years old and nurses use medical hand washing liquid for diagnosis with hyperkeratosis interphalangeal joints, desquamation with pruritus for 1 week during epidemic period, and the patients are in good health and deny medicine allergy history, trauma history and system disease history and are examined: keratosis, desquamation and severe pruritus of interphalangeal joints, aggravation of alkaline articles such as hand washing liquid, facial cleanser or soap, and rhagadia and pain in severe cases. The product of the invention in example 2 is applied to the skin lesion for 2 times per day, which is recommended to avoid contacting alkaline articles and avoid pungent and fishy foods. After being taken for 5 days, the chap heals, the desquamation is obviously reduced, and the pruritus is occasionally caused by heat. The treatment is continued for 7 days, and the skin recovers as before. After the patients were ordered to contact the alkaline substance, the patients were administered the product of the present invention in the protective external use for 2 months without repeating the disease.
Patient 2, Sunzhi, male, 13 years old, children, because of lip cornification, rhagadia and pain 1 month visit, both healthy and strong, deny the history of drug allergy, long-term taking and systematic disease history, check: lip skin is redder, with cornification, chapping and desquamation, the infant is ill because of licking habit of the lips at the beginning, the disease condition is aggravated after the external dermatitis is flat, the irritation of spicy food is difficult to heal repeatedly, the product of the invention example 2 is externally applied to the skin lesion, the spicy fishy food is prohibited for 2 times per day, and the lip skin lesion is prevented from being stimulated by diet. After 10 days, the chap heals, the desquamation is obviously reduced, and the accidental pain is not suitable for eating. After 14 days, the skin of the lips was recovered as usual. The disease condition is not repeated after 1 month of diagnosis.
Patient 3, forest a, woman, 28 years old, the teacher sees a doctor because of the hyperkeratosis of right hand thumb, forefinger and desquamation for 2 years, and both healthy and strong, deny medicine allergy history, long-term history of taking medicine and system disease history, inspection: the skin of the index finger and the thumb of the right hand is thick, with keratosis and desquamation, and chapping in severe cases, the career cause is aggravated due to the contact of the hand with chalk, the illness state in holidays is relieved, the people are difficult to heal repeatedly, the product of the invention in the example 2 is externally applied to the skin lesion for 2 times per day, and the people are advised not to eat spicy and fishy foods, so that the stimulation of contacting alkaline substances is avoided. After 2 weeks of administration, the chap heals, the skin lesions become thin, desquamation is reduced obviously, and the administration is continued for 1 month. Daily attention is paid to protection, and the recovery is as usual in 3 months. The disease condition is not repeated after 1 month of diagnosis.
Patient 4, Zhangzhi, male, age 39, baker, who visited the diagnosis for 5 years of itching due to hyperkeratosis and hypertrophy of the interphalangeal joints, denied chronic medical history, denied medical allergy history, long-term medical history and systemic disease history, and examined: the skin of the interphalangeal joints of the two fingers is thick and accompanied with desquamation, the itching is severe after the contact with hot water, the repeated healing is difficult to achieve due to the fact that the skin is contacted with alkaline surface in the following points, and when the itching is severe, the skin is scratched to bleed, the product of the invention in the embodiment 2 is externally applied to the skin lesion for 3 times/day, and spicy food is advised to be avoided, so that the stimulation of the contact with alkaline articles is avoided. After 2 weeks of administration, pruritus is obviously relieved, skin lesions become thin, desquamation is obviously reduced, and the administration is followed for 1 month. The water contact is reduced, and the recovery is as usual in half a year. The disease condition is not repeated after 2 months of diagnosis.
Patient 5, jinzhi, woman, age 52, farmer, who has a diagnosis for rhagadia and pain in both heels for more than 2 years, denied the history of drug allergy, long-term medication and systematic disease history, and examined: the skin of the heels is thick, and the heels are chapped, have little desquamation and have severe walking pain, so that the daily life is influenced. The product of the invention in example 2 is applied to the skin lesion for 3 times/day, and is matched with an external preservative film package to promote the absorption of the medicine, avoid pungent food and reduce the stimulation of contacting alkaline articles. After 10 days, most chaps heal, skin damage becomes thin, desquamation is obviously reduced, and the prescription is continued for 1 month. Avoid the stimulation of the drugs, and recover as usual in 3 months. The disease condition is not repeated after 1 month of diagnosis.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.
Claims (7)
1. The composition for treating the keratotic skin diseases is characterized by being prepared from the following raw materials in parts by weight: 4000-6000 parts of white vaseline, 100-120 parts of raw angelica, 100-120 parts of salvia miltiorrhiza, 60-80 parts of prepared fleece-flower root, 60-80 parts of cassia twig, 60-80 parts of raw garden burnet root, 60-80 parts of clematis root, 60-80 parts of madder, 60-80 parts of barbed skullcap herb, 40-60 parts of bletilla striata, 40-60 parts of cortex dictamni, 10-20 parts of borneol and 4-6 parts of maca extract.
2. The composition for treating an actinic skin disorder according to claim 1, wherein the composition is prepared from the following raw materials in parts by weight: 5000 parts of white vaseline, 110 parts of raw angelica, 110 parts of salvia miltiorrhiza, 70 parts of prepared polygonum multiflorum, 70 parts of cassia twig, 70 parts of raw sanguisorba, 70 parts of radix clematidis, 70 parts of madder, 70 parts of barbed skullcap herb, 50 parts of bletilla striata, 50 parts of cortex dictamni, 15 parts of borneol and 5 parts of maca extract.
3. The composition for treating an actinic skin disorder according to claim 2, wherein said composition is in the form of an ointment.
4. A process for the preparation of a composition for the treatment of an actinic skin disorder according to any one of claims 1 to 3, comprising the steps of:
1) melting white vaseline in an enamel basin until the white vaseline is boiled;
2) adding radix Angelicae sinensis, Saviae Miltiorrhizae radix, radix Polygoni Multiflori Preparata, ramulus Cinnamomi, radix Sangusorbae, radix Clematidis, radix Rubiae, and herba Scutellariae Barbatae at a certain weight ratio, continuously frying for 20-30 min until the herbs are all brown, sieving to remove brown herbs, adding extracts of rhizoma Bletillae, cortex Dictamni Radicis and Lepidium Meyenii Walp, stirring, and standing;
3) standing to 40-50 deg.C, adding Borneolum Syntheticum, stirring, cooling to solidify, and making into unguent.
5. The method for preparing a composition for the treatment of an actinic skin disorder according to claim 4, wherein the melting temperature in step 1) is 100-120 ℃.
6. The method for preparing a composition for the treatment of an actinic skin disorder according to claim 4, wherein the sieving in step 2) is a 50 mesh sieve.
7. The method of preparing a composition for the treatment of keratinized skin disease according to claim 4, wherein the bletilla striata and the cortex dictamni are respectively a wall-broken bletilla striata powder and a cortex dictamni powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011030517.7A CN112057555B (en) | 2020-09-27 | 2020-09-27 | A composition for treating keratotic skin diseases and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011030517.7A CN112057555B (en) | 2020-09-27 | 2020-09-27 | A composition for treating keratotic skin diseases and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112057555A CN112057555A (en) | 2020-12-11 |
| CN112057555B true CN112057555B (en) | 2022-04-12 |
Family
ID=73682842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011030517.7A Active CN112057555B (en) | 2020-09-27 | 2020-09-27 | A composition for treating keratotic skin diseases and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112057555B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614310A (en) * | 2012-03-02 | 2012-08-01 | 李金辉 | Dehumidifying lotion for treating keratosic dermatosis and preparation method thereof |
| CN111617189A (en) * | 2020-07-06 | 2020-09-04 | 河南省人民医院 | Traditional Chinese medicine composition for treating dry skin chap |
-
2020
- 2020-09-27 CN CN202011030517.7A patent/CN112057555B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614310A (en) * | 2012-03-02 | 2012-08-01 | 李金辉 | Dehumidifying lotion for treating keratosic dermatosis and preparation method thereof |
| CN111617189A (en) * | 2020-07-06 | 2020-09-04 | 河南省人民医院 | Traditional Chinese medicine composition for treating dry skin chap |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112057555A (en) | 2020-12-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108938759B (en) | Medicine or daily chemical product composition for treating hand-foot syndrome and preparation method and application thereof | |
| CN104491695A (en) | Pharmaceutical composition for treating chloasma | |
| CN107669935A (en) | A kind of Chinese medicine antiallergy beauty mask and preparation method thereof | |
| CN106937988A (en) | A kind of nti-freckle menstruation regulating Chinese medicine composition and preparation method thereof | |
| CN103599455B (en) | Traditional Chinese medicine capsule for removing freckle | |
| CN112057555B (en) | A composition for treating keratotic skin diseases and its preparation method | |
| CN113041296B (en) | Traditional Chinese medicine composition for treating atopic dermatitis | |
| CN108042729A (en) | A kind of anti-acne ointment containing radix tarxaci | |
| CN101336998B (en) | Traditional Chinese medicine for treating whelk | |
| CN107714798A (en) | A Chinese medicinal composition for treating chloasma, and its preparation method | |
| KR101828815B1 (en) | Herbal food for alleviates dysmenorrhea and method for preparing the same | |
| Teoh et al. | Comprehension and experience of acne treated with traditional chinese medicine facial mask of bai zhi (Radix Angelicae Formosanae) and bai fu zi (Rhizoma Typhonii Gigantei) as the basis formula by external application | |
| CN105343423B (en) | A kind of drug and preparation method thereof for treating eczema | |
| CN110575509B (en) | Traditional Chinese medicine composition for treating acne | |
| CN109865017A (en) | A kind of paste and preparation method thereof of easy-to-use treatment acne | |
| CN107661391A (en) | Treat Yao nationality medicine external preparation of the proliferation of mammary gland and preparation method thereof | |
| CN102114203A (en) | Traditional Chinese medicine composition for treating acnes | |
| CN106728367A (en) | Treat the Chinese medicine of white hair | |
| Chen | Herbology in Three Traditional Medicines for Acne | |
| CN1055002C (en) | External-use cream for treatment of breast cancer | |
| CN106177208A (en) | A kind of subhealth state that regulates causes the Chinese herbal and crude drugs preparations of insomnia agitation | |
| Smarta | Home remedies and traditional medicines for energy and nutrition | |
| CN1090493C (en) | Chinese medicine preparation for pulmonary tuberculosis and its preparation | |
| CN104383211A (en) | Traditional Chinese medicine clysis fluid for treating chronic renal insufficiency and yang deficiency-induced cold of diabetic nephropathy | |
| CN118370794A (en) | Medicated diet for assisting in treating acne, preparation method, composition and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Gong Anming Inventor after: Yang Xiaoli Inventor after: Xu Lijuan Inventor before: Xu Lijuan Inventor before: Gong Anming Inventor before: Yang Xiaoli |
|
| CB03 | Change of inventor or designer information | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20220318 Address after: 100000 - 644, No. 9, Government Street, Beiwu Town, Shunyi District, Beijing Applicant after: AoXiang Biotechnology (Beijing) Co.,Ltd. Address before: 066000 Haigang District, Qinhuangdao City, Hebei Province Applicant before: Xu Lijuan |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |