WO2021212537A1 - 试剂存储装置 - Google Patents

试剂存储装置 Download PDF

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Publication number
WO2021212537A1
WO2021212537A1 PCT/CN2020/087497 CN2020087497W WO2021212537A1 WO 2021212537 A1 WO2021212537 A1 WO 2021212537A1 CN 2020087497 W CN2020087497 W CN 2020087497W WO 2021212537 A1 WO2021212537 A1 WO 2021212537A1
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WO
WIPO (PCT)
Prior art keywords
reagent
storage device
reagent storage
hot
cold
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PCT/CN2020/087497
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English (en)
French (fr)
Inventor
张震
何太云
李双龙
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深圳迎凯生物科技有限公司
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Publication of WO2021212537A1 publication Critical patent/WO2021212537A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D19/00—Arrangement or mounting of refrigeration units with respect to devices or objects to be refrigerated, e.g. infrared detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00613—Quality control
    • G01N35/00663—Quality control of consumables
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00435—Refrigerated reagent storage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00613—Quality control
    • G01N35/00663—Quality control of consumables
    • G01N2035/00673—Quality control of consumables of reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00752—Type of codes bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0429—Sample carriers adapted for special purposes
    • G01N2035/0436—Sample carriers adapted for special purposes with pre-packaged reagents, i.e. test-packs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0443—Rotary sample carriers, i.e. carousels for reagents

Definitions

  • the present invention relates to the technical field of medical devices, in particular to a reagent storage device.
  • the immunoassay system uses the principle of chemiluminescence or excitation fluorescence and immune reaction to correlate the light signal with the concentration of the test substance to analyze the content of the test substance in the sample. Due to its high sensitivity, specificity, and wide linear range, it is gaining more and more attention. Applications. With the increase in the amount of test specimens, clinical laboratories have higher and higher requirements for the volume and test throughput of the immunoassay system.
  • the reagent storage device is an important part of the immune analysis system, and the reagent storage device has an important influence on the volume and test throughput of the entire immune analysis system.
  • the accommodating space for setting the reagent container on the reagent tray is usually increased, which causes the volume of the entire reagent storage device to become larger.
  • the movement control of the reagent storage device becomes more difficult, and it also poses a greater challenge to the processing accuracy of the reagent storage device.
  • a reagent storage device that can ensure a compact structure is provided.
  • a reagent storage device including:
  • a pot body, the pot body is provided with an accommodating cavity
  • a storage mechanism includes at least two storage units, each of the storage units includes a turntable and a reagent box located in the accommodating cavity, the turntable can rotate in the accommodating cavity, the The reagent box is set on the turntable and used to store reagents; and
  • the refrigeration mechanism is connected with the pot body to keep the accommodating cavity at a set temperature.
  • FIG. 1 is a schematic diagram of a three-dimensional structure of a reagent storage device provided by an embodiment
  • FIG. 2 is a schematic diagram of an exploded structure of the reagent storage device shown in FIG. 1;
  • FIG. 3 is a schematic diagram of a partial structure of the reagent storage device shown in FIG. 1 with a support plate removed;
  • FIG. 4 is a schematic diagram of a partial structure of the reagent storage device shown in FIG. 1 including a storage unit;
  • FIG. 5 is a schematic diagram of the three-dimensional structure of FIG. 4 from another perspective
  • Fig. 6 is a schematic diagram of an enlarged structure at A in Fig. 5;
  • FIG. 7 is a partial three-dimensional cross-sectional structure diagram of the reagent storage device shown in FIG. 1.
  • the reagent storage device 10 provided by an embodiment of the present invention includes a pot body 100, a storage mechanism 200 and a refrigeration mechanism 300, and the storage mechanism 200 includes at least two storage units 210.
  • the pot body 100 includes a side frame 110, a top cover 120, and a bottom cover 130.
  • the bottom cover 130 and the top cover 120 are both in a flat structure and arranged horizontally, and the side frame 110 is in a ring structure and arranged vertically.
  • the top cover 120 is connected to the upper end of the side frame 110
  • the bottom cover 130 is connected to the lower end of the side frame 110
  • the bottom cover 130, the top cover 120 and the side frame 110 enclose a closed accommodating cavity 101.
  • the cross-sectional shape of the side frame 110 is a rectangle or a racetrack shape, which makes the side frame 110 easy to process, so that the entire pot body 100 can well ensure the processing accuracy on the basis of lower processing costs.
  • At least two sets of sampling ports 121 are provided on the top cover 120, and each set of sampling ports 121 corresponds to a storage unit 210 for sampling needles to pass in and out of the storage unit 210 to suck reagents.
  • Each group of sampling ports 121 can allow sampling needles to reach multiple cavities on the reagent box 212 of the storage unit 210.
  • each storage unit 210 includes a turntable 211, a reagent box 212, a mixing gear 213, a rotating shaft 214, and a driver 215. Both the turntable 211, the reagent box 212 and the mixing gear 213 are located in the accommodating cavity 101, and the driver 215 is located outside the accommodating cavity 101.
  • the rotating shaft 214 passes through the bottom cover 130 of the pot body 100, the upper end of the rotating shaft 214 is connected with the turntable 211, and the lower end of the rotating shaft 214 is located outside the accommodating cavity 101 and connected with the driver 215.
  • the turntable 211 is a disc-shaped structure.
  • the turntable 211 is provided with a plurality of installation positions, which are arranged at intervals along the circumference of the turntable 211.
  • the reagent box 212 and the installation positions are in a one-to-one relationship, and the reagent box 212 is fixed in the installation position.
  • the number of installation positions on each turntable 211 may be 15-50, for example, the number of installation positions on each turntable 211 may be 25, so that two turntables 211 can simultaneously store 50 reagent kits 212 online.
  • Each storage unit 210 is loaded with all the reagent components required by the corresponding analysis item, so that the sampling needle can absorb all the reagent components of the analysis item on the same storage unit 210, preventing one analysis item from needing to be stored in two storage units 210. Reagents are sucked, thereby effectively avoiding the problems of low efficiency of sucking reagents in the same project and inconvenient loading and unloading of the reagent box 212.
  • the driver 215 is used to drive the rotating shaft 214 to rotate, and then the rotating shaft 214 drives the rotating disk 211 to rotate.
  • the rotating disk 211 rotates around the rotating shaft 214, the relative position of the reagent cartridge 212 and the rotating disk 211 remains constant, and the reagent cartridge 212 follows the rotating disk 211 around the rotating shaft 214. Do a revolution.
  • the reagent box 212 includes a box body 212a, a rotating reagent bottle 212b, a homogeneous reagent bottle 212c, and a transmission gear.
  • the box body 212a is arranged on the installation position of the turntable 211, and a plurality of cavities can be opened on the box body 212a, and the rotating reagent bottle 212b and the homogeneous reagent bottle 212c are accommodated in different cavities.
  • the number of homogeneous reagent bottles 212c may be multiple, and each homogeneous reagent bottle 212c contains reagents of specific composition.
  • the reagents contained in the homogeneous reagent bottle 212c are referred to as homogeneous reagents.
  • the homogeneous reagents contained in different homogeneous reagent bottles 212c have different components. Homogeneous reagents are usually in solution. When the entire reagent box 212 rotates following the turntable 211, the homogeneous reagent bottle 212c remains stationary in the cavity, and the homogeneous reagent bottle 212c will not rotate relative to the box body 212a.
  • the number of the rotating reagent bottle 212b may be one, and the rotating reagent bottle 212b is placed in the most edge cavity of the box body 212a, which is closer to the mixing gear 213 than other cavities.
  • the rotating reagent bottle 212b is used to contain the reagent in a suspension state, and the reagent is recorded as a solid phase reagent.
  • the solid phase reagent the solid magnetic particles are in a suspended state.
  • the rotating reagent bottle 212b can be cylindrical.
  • the cavity containing the rotating reagent bottle 212b can also be cylindrical.
  • the rotating reagent bottle 212b is inserted into the cylindrical cavity, and the transmission gear is connected or installed in the rotating reagent.
  • the bottom of the bottle 212b is located outside the cavity, the transmission gear is an external gear, and the mixing gear 213 may be an internal gear.
  • the mixing gear 213 is arranged around the turntable 211, and the transmission gear and the mixing gear 213 mesh with each other. Therefore, when the rotating shaft 214 drives the turntable 211 to rotate, the box body 212a follows the rotation of the turntable 211 and revolves around the rotating shaft 214, so that both the rotating reagent bottle 212b and the homogeneous reagent bottle 212c revolve around the rotating shaft 214.
  • the rotating reagent bottle 212b can revolve and rotate at the same time, and the action of the revolving and rotating motion at the same time causes the suspension in the rotating reagent bottle 212b to vibrate strongly, thereby making the suspension
  • the solid phase reagent in the state forms a turbulent flow, and finally the solid magnetic particles in the solid phase reagent are always in a suspended state, that is, the solid phase reagent is mixed uniformly to prevent the solid magnetic particles from depositing on the bottom of the rotating reagent bottle 212b, so as to subsequently pass through the sampling needle
  • the extracted solid phase reagent contains a certain proportion of solid magnetic particles to ensure the accuracy of subsequent test results. Since the homogeneous reagent bottle 212c contains the homogeneous reagent in a solution state, the homogeneous reagent bottle 212c does not need to be mixed.
  • the mixing gear 213 is a circular gear.
  • the mixing gear 213 can be formed by splicing a plurality of arc-shaped racks 213a instead of an integral processing method.
  • the rack 213a can reduce the manufacturing cost of related molds or fixtures, and at the same time reduce the processing difficulty, so that it is easy to ensure the processing accuracy and processing efficiency of a single arc-shaped rack 213a.
  • the various arc-shaped racks 213a are spliced to form a blend After the gear 213, the size and shape accuracy of the blending gear 213 after splicing can also be well ensured.
  • the drive 215 is located under the bottom cover 130, and the turntable 211 is located above the bottom cover 130, so that the drive 215 and the turntable 211 are located on opposite sides of the bottom cover 130.
  • the driver 215 includes a support plate 140, a motor 215a, a driving wheel 215b, a driven wheel 215c, and a timing belt 215d.
  • the motor 215a, the driving wheel 215b and the driven wheel 215c are all arranged on the supporting plate 140.
  • the supporting plate 140 faces the motor 215a,
  • the driving wheel 215b and the driven wheel 215c play a bearing and installation role.
  • the motor 215a can be a servo motor 215a or a stepping motor 215a.
  • the motor 215a rotates intermittently.
  • the rotating wheel is connected to the output shaft of the motor 215a.
  • the driven wheel 215c is connected to the lower end of the rotating shaft 214.
  • the timing belt 215d is sleeved on the driving wheel.
  • the diameter of the driven wheel 215c is larger than the diameter of the driving wheel 215b, so that the driven wheel 215c decelerates the movement output by the driving wheel 215b and increases the torque of the driven wheel 215c.
  • the rotating shaft 214 can drive the turntable 211 to move intermittently.
  • the sample needle can be used to suck solid phase reagents and homogeneous reagents in the rotating reagent bottle 212b and homogeneous reagent bottle 212c. Phase reagents for subsequent measurement and analysis.
  • the two turntables 211 alternately and independently transfer the target reagent cartridges 212 on them to the bottom of the corresponding sampling port at regular intervals for the respective sampling needles to suck reagents. This can further reduce the requirement on the rotation speed of the turntable 211, which is beneficial to further reduce the load requirement on the drive and reduce the difficulty of drive control.
  • a turntable 211 is installed to increase the load capacity of the reagent box 212, so that the turntable The total weight of 211 and the reagent cartridge 212 carried by the turntable 211 increases, which in turn causes the load of the drive 215 to be too large, which leads to an increase in the technical difficulty of drive control of the drive 215.
  • the size of the turntable 211 is too large, it is difficult to ensure its own processing accuracy.
  • the reagent storage device 10 in the above embodiment by arranging two storage units 210 on the same pot 100, that is, there are two turntables 211 in the accommodating cavity 101. Due to the increase in the number of turntables 211, the single turntable 211 When the number of installation positions remains the same or even decreases, the total number of installation positions of the two turntables 211 is increased, so that the carrying number of the reagent cartridges 212 in the entire reagent storage device 10 can also be increased, thereby meeting the requirements of test throughput.
  • the other storage unit 210 can continue to work, avoiding the phenomenon that the traditional reagent storage device 10 cannot work completely due to the failure of one storage unit 210, thereby The reliability and tolerance to failure of the entire reagent storage device 10 are also improved.
  • the failed storage unit 210 can be repaired, so as to subsequently restore the state in which the two storage units 210 can be used at the same time.
  • the refrigeration mechanism 300 includes a cold end unit 310, a hot end unit 320, cooling fins 330, a heat insulation plate 340 and a heat dissipation air duct 323, and the cold end unit 310 is located In the accommodating cavity 101, the hot end unit 320 and the heat dissipation air duct 323 are located outside the accommodating cavity 101.
  • the number of cold end units 310 is at least two, for example, the number of cold end units 310 is an even number and is divided into one or more pairs.
  • the at least two cold end units 310 are symmetrically distributed in the accommodating cavity 101 along the line connecting the centers of the at least two turntables 211 or the vertical center line of the center connecting the at least two turntables 211. This not only helps to improve the refrigeration efficiency, but also helps to maintain the temperature uniformity of the points in the accommodating cavity 101.
  • the cold end unit 310 is located in the gap between the two turntables 211 and is symmetrically distributed along the line connecting the centers of the two turntables 211. This not only makes full use of the space between the two turntables 211 in the accommodating cavity 101, but also facilitates the layout of the whole machine, so that the limited accommodating cavity 101 can accommodate more parts, thereby reducing the volume of the entire pot 100 .
  • the cold end unit 310 includes a cold end heat sink 311, a cold end fan 312, and a mounting seat 313.
  • the cold end heat sink 311 is connected to the cold end of the cooling fin 330, and the mounting seat 313 is close to the bottom cover 130 of the pot body 100.
  • the end heat sink 311 is connected, and the cold end fan 312 is fixed on the mounting seat 313.
  • the hot-end unit 320 includes a hot-end heat sink 321 and a hot-end fan 322.
  • the hot-end heat sink 321 is connected to the bottom cover 130 of the pot body 100 and is used to absorb heat from the hot end of the cooling fin 330.
  • the number of the hot-end fans 322 is at least two. .
  • the two hot-end fans 322 are respectively fixed on both ends of the hot-end heat sink 321.
  • the heat dissipation air duct 323 is connected to the end of the hot end heat sink 321, the hot end heat sink 321 is arranged around the hot end fan 322, and the hot end fan 322 discharges the heat of the hot end heat sink 321 from the heat dissipation air duct 323.
  • the number of heat dissipation air ducts 323 can be two, that is, both ends of the hot end heat sink 321 are connected with a heat dissipation air duct 323.
  • the number of heat dissipation air ducts 323 can be one, that is, Only one end of the hot end heat sink 321 is connected with a heat dissipation air duct 323.
  • the heat dissipation air duct 323 is located below the pot body 100, which can save space on the periphery of the pot body 100 and leave space for the arrangement of other devices of the whole machine. Furthermore, the heat dissipation air duct 323 is located below the center of the pot body 100 and passes through the gap between the two drivers 215, which further saves the space of the entire device.
  • the bottom cover 130 may be provided with a through hole, and the heat insulation plate 340 and the cooling fin 330 may be installed in the through hole, so that the heat insulation plate 340 and the cooling fin 330 are sandwiched between the hot end heat sink 321 and the cold end heat sink 321 Between 311.
  • the refrigeration sheet 330 may be a Peltier refrigeration sheet 330 made of semiconductor materials. When the refrigeration mechanism 300 is working, the cold end of the refrigerating fin 330 produces refrigeration and is transferred to the accommodating cavity 101 through the cold end heat sink 311. The heat is discharged from the heat dissipation air duct 323 to the outside. For the cold end fans 322 on the same pair of cold end units 310, the blowing direction is opposite.
  • the cold-end fan 312 on one of the cold-end units 310 is used to draw air from the cold-end heat sink 311, and the cold-end fan 312 on the other cold-end unit 310 is used to blow air to the cold-end heat sink 311, which can accelerate the capacity.
  • the air flow in the cavity 101 is circulated, thereby improving the cooling effect in the accommodating cavity 101, ensuring that all spaces in the accommodating cavity 101 are kept at the same temperature, so that all reagents in the reagent box 212 maintain the same temperature.
  • the two turntables 211 drive the reagent cartridges 212 on them to rotate independently, which can agitate the air in the accommodating cavity 101, further accelerate the flow of cold air, and maintain temperature uniformity.
  • the two storage units 210 share a pot body 100
  • the two turntables 211 are both located in the accommodating cavity 101 in the same pot body 100, and the refrigerating mechanism 300 is connected to the pot body 100.
  • the refrigerating mechanism 300 produces a cooling effect
  • the accommodating cavity 101 is maintained at a set temperature (2-8 degrees Celsius)
  • the reagent kits 212 on the two turntables 211 are all located in the refrigerated environment (accommodating cavity 101) at the same temperature, so that all reagents in all the reagent kits 212 are The components are kept at the same temperature, thereby ensuring the temperature consistency of the reagents stored in the entire reagent storage device 10, reducing the impact on the performance of the reagents due to temperature inconsistencies, and ensuring the accuracy of subsequent test results.
  • the two cold end units 310 share the same heat dissipation air duct 323, which can reduce the number of heat dissipation air ducts 323, thereby making the reagent storage structure more compact. Furthermore, the cold end unit 310 is located in the gap between the two turntables 211, and the hot end heat sink 321 is located below the cold end heat sink 311, which is more conducive to the spatial distribution of the hot end heat sink 321 and the heat dissipation air duct 323. overall arrangement.
  • the reagent storage device 10 further includes a scanner 400, which is disposed on the inner wall surface of the side frame 110, so that the scanner 400 is located in the accommodating cavity 101 of the pot 100, that is, scanning
  • the device 400 can make full use of the existing installation space of the accommodating cavity 101 and does not need to occupy the installation space outside the accommodating cavity 101, thereby improving the structural compactness of the reagent storage device 10.
  • the number of scanners 400 and the number of turntables 211 may be equal, that is, each turntable 211 corresponds to one scanner 400.
  • the scanner 400 is used to scan the barcode on the reagent kit 212, so as to identify the barcode information on the reagent kit 212, so as to identify and distinguish the reagents of different analysis items.
  • the scanner 400 adopts a fixed design, that is, the scanner 400 is directly fixedly connected to the side frame 110, which also makes the reagent storage device 10 more compact and reduces the manufacturing cost.

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  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Quality & Reliability (AREA)
  • Combustion & Propulsion (AREA)
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  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

一种试剂存储装置(10)，包括：锅体(100)，所述锅体(100)开设有容置腔(101)；存储机构(200)，所述存储机构(200)包括至少两个存储单元(210)，每个所述存储单元(210)包括位于所述容置腔(101)内的转盘(211)和试剂盒(212)，所述转盘(211)可以在所述容置腔(101)内转动，所述试剂盒(212)设置在所述转盘(211)上并用于存储试剂；及制冷机构(300)，所述制冷机构(300)与所述锅体(100)连接以使所述容置腔(101)保持设定温度。通过在同一锅体上设置至少两个存储单元，能够增加整个试剂存储装置中的试剂盒的承载数量，从而满足测试通量的要求。

Description

试剂存储装置 技术领域
本发明涉及医疗器械技术领域，特别是涉及一种试剂存储装置。
背景技术
免疫分析系统利用化学发光或激发荧光和免疫反应原理，将光信号与待测物质浓度关联以分析样本中的待测物质含量，由于其高灵敏度和特异性、宽线性范围等特性正获得日益广泛的应用。随着检测标本量的增加，临床实验室对免疫分析系统的体积和测试通量的要求越来越高。
试剂存储装置是免疫分析系统的重要组成部分，试剂存储装置对整个免疫分析系统的体积和测试通量有重要的影响。对于传统的试剂存储装置，为增加试剂盘对试剂容器的存储量以提高测试通量，通常会增加试剂盘上用于设置试剂容器的容纳位，从而导致整个试剂存储装置的体积变大。由于试剂存储装置的体积变大，会使得试剂存储装置的运动控制难度增大，同时也对试剂存储装置的加工精度构成较大的挑战。
发明内容
根据本申请的各种实施例，提供一种能在确保结构紧凑的试剂存储装置。
一种试剂存储装置，包括：
锅体，所述锅体开设有容置腔；
存储机构，所述存储机构包括至少两个存储单元，所述每个存储单元包括位于所述容置腔内的转盘和试剂盒，所述转盘可以在与所述容置腔内转动，所述试剂盒设置在所述转盘上并用于存储试剂；及
制冷机构，所述制冷机构与所述锅体连接以使所述容置腔保持设定温度。
本发明的一个或多个实施例的细节在下面的附图和描述中提出。本发明 的其它特征、目的和优点将从说明书、附图以及权利要求书变得明显。
附图说明
为了更好地描述和说明这里公开的那些发明的实施例和/或示例，可以参考一幅或多幅附图。用于描述附图的附加细节或示例不应当被认为是对所公开的发明、目前描述的实施例和/或示例以及目前理解的这些发明的最佳模式中的任何一者的范围的限制。
图1为一实施例提供的试剂存储装置的立体结构示意图；
图2为图1所示试剂存储装置的分解结构示意图；
图3为图1所示试剂存储装置去掉支撑板后的局部结构示意图；
图4为图1所示试剂存储装置包括存储单元在内的局部结构示意图；
图5为图4在另一视角下的立体结构示意图；
图6为图5中A处放大结构示意图；
图7为图1所示试剂存储装置的局部立体剖视结构示意图。
具体实施方式
为了便于理解本发明，下面将参照相关附图对本发明进行更全面的描述。附图中给出了本发明的较佳实施方式。但是，本发明可以以许多不同的形式来实现，并不限于本文所描述的实施方式。相反地，提供这些实施方式的目的是使对本发明的公开内容理解的更加透彻全面。
需要说明的是，当元件被称为“固定于”另一个元件，它可以直接在另一个元件上或者也可以存在居中的元件。当一个元件被认为是“连接”另一个元件，它可以是直接连接到另一个元件或者可能同时存在居中元件。本文所使用的术语“内”、“外”、“左”、“右”以及类似的表述只是为了说明的目的，并不表示是唯一的实施方式。
同时参阅图1和图2，本发明一实施例提供的试剂存储装置10包括锅体100、存储机构200和制冷机构300，存储机构200包括至少两个存储单元210。
在一些实施例中，锅体100包括侧框110、顶盖120和底盖130，底盖130和顶盖120两者呈平板状结构并水平设置，侧框110呈环状结构并竖直设置，顶盖120与侧框110的上端连接，底盖130与侧框110的下端连接，底盖130、顶盖120和侧框110围成一个封闭的容置腔101。侧框110的横截面形状为长方形或跑道形，这样使得侧框110容易加工，使得整个锅体100在加工成本较低的基础上能很好地保证加工精度。顶盖120上设置至少两组采样口121，每组采样口121对应一个存储单元210，供采样针进出该存储单元210吸取试剂。每组采样口121可供采样针到达存储单元210的试剂盒212上的多个腔体。
同时参阅图2、图3和图4，在一些实施例中，存储单元210可以为两个或两个以上，本实施例以两个存储单元210为例进行说明。每个存储单元210包括转盘211、试剂盒212、混匀齿轮213、转轴214和驱动器215。转盘211、试剂盒212和混匀齿轮213三者两者位于容置腔101之内，驱动器215位于容置腔101之外。转轴214穿设在锅体100的底盖130中，转轴214的上端与转盘211连接，转轴214的下端位于容置腔101之外而与驱动器215连接。转盘211为圆盘状结构，转盘211上设置有多个安装位，多个安装位沿转盘211的周向间隔设置，试剂盒212与安装位呈一一对应关系，试剂盒212固定在安装位上，每个转盘211上的安装位的数量可以为15至50个，例如每个转盘211上的安装位的数量可以为25个，使得两个转盘211同时可以在线存储50个试剂盒212。每个存储单元210装载有相应分析项目所需的全部试剂组分，使得采样针在同一个存储单元210上即可吸取分析项目的全部试剂组分，防止一个分析项目需要在两个存储单元210吸取试剂，从而有效避免同一项目吸取试剂效率低、试剂盒212装卸不便等问题。
驱动器215用于驱动转轴214转动，继而使得转轴214带动转盘211转动，当转盘211绕转轴214做自转运动时，试剂盒212与转盘211的相对位置保持恒定，试剂盒212跟随转盘211绕转轴214做公转运动。
同时参阅图5和图6，试剂盒212包括盒体212a、转动试剂瓶212b、均 相试剂瓶212c和传动齿轮。盒体212a设置在转盘211的安装位上，盒体212a上可以开设多个腔体，转动试剂瓶212b和均相试剂瓶212c则收容在不同的腔体中。均相试剂瓶212c的数量可以为多个，每一个均相试剂瓶212c中盛放有特定组成成分的试剂。均相试剂瓶212c中盛放的试剂记为均相试剂，对于同一个盒体212a上的均相试剂瓶212c，不同均相试剂瓶212c中所盛放的均相试剂的组成成分不同。均相试剂通常为溶液状态。在整个试剂盒212跟随转盘211转动的过程中，均相试剂瓶212c在腔体中保持不动，均相试剂瓶212c不会相对盒体212a产生自转。
转动试剂瓶212b的数量可以为一个，转动试剂瓶212b放置在盒体212a最边缘的腔体中，该最边缘的腔体相对其它腔体更加靠近混匀齿轮213。转动试剂瓶212b中用于盛放呈悬浮液状态的试剂，该试剂记为固相试剂，对于该固相试剂，固体磁微粒处于悬浮状态。转动试剂瓶212b可以呈圆柱形，当然，容置该转动试剂瓶212b的腔体同样可以为圆柱形，转动试剂瓶212b插置在该圆柱形的腔体中，传动齿轮连接或安装在转动试剂瓶212b的底部而位于腔体之外，传动齿轮为外齿轮，混匀齿轮213可以为内齿轮，混匀齿轮213环绕转盘211设置，传动齿轮与混匀齿轮213相互啮合。因此，当转轴214驱动转盘211转动时，盒体212a跟随转盘211转动而绕转轴214做公转运动，使得转动试剂瓶212b和均相试剂瓶212c两者均绕转轴214做公转运动，同时，由于转动试剂瓶212b底部的传动齿轮与混匀齿轮213相互啮合，使得混匀齿轮213通过传动齿轮以驱动转动试剂瓶212b绕自身中心轴线相对盒体212a产生转动，即转动试剂瓶212b在盒体212a中产生自转。
因此，当转轴214驱动转盘211转动时，可以使得转动试剂瓶212b同时产生公转和自转，同时公转和自转运动的作用，使得转动试剂瓶212b中的悬浮液产生比较强烈的振荡，从而使得悬浮液状态的固相试剂形成紊流，最终使得固相试剂中的固体磁微粒始终处于悬浮状态，即使得固相试剂混匀，避免固体磁微粒沉淀在转动试剂瓶212b的底部，以便后续通过采样针抽取的固相试剂中含有一定比例的固体磁微粒，以保证后续测试结果的准确性。由于 均相试剂瓶212c中盛放溶液状态的均相试剂，均相试剂瓶212c不需要混匀。
参阅图6，混匀齿轮213为圆形齿轮，混匀齿轮213可以不采用一体成型的加工方式，而是采用多个圆弧形齿条213a相互拼接而成，由于尺寸较小的圆弧形齿条213a可以减少相关模具或夹具的制造成本，同时也降低了加工难度，这样容易保证单个圆弧形齿条213a的加工精度和加工效率，当将各个圆弧形齿条213a拼接形成混匀齿轮213后，同样能够很好地保证拼接后混匀齿轮213的尺寸和形位精度。因此，通过将多个容易提高加工精度和效率的圆弧形齿条213a拼接形成混匀齿轮213后，既可以有效降低整个混匀齿轮213的总制造成本，还可以提高混匀齿轮213的加工效率和加工精度。
同时参阅图3和图4，驱动器215位于底盖130的下方，而转盘211位于底盖130的上方，使得驱动器215和转盘211分居底盖130的相对两侧。驱动器215包括支撑板140、电机215a、主动轮215b、从动轮215c和同步带215d，电机215a、主动轮215b和从动轮215c三者均设置在该支撑板140上，支撑板140对电机215a、主动轮215b和从动轮215c起到承载和安装作用。电机215a可以为伺服电机215a或步进电机215a等，该电机215a做间歇性转动，转动轮与电机215a的输出轴连接，从动轮215c与转轴214的下端连接，同步带215d套设在主动轮215b和从动轮215c上，从动轮215c的直径大于主动轮215b的直径，使得从动轮215c对主动轮215b输出的运动进行减速，提高从动轮215c的扭矩。当电机215a转动时，可以通过转轴214带动转盘211座间歇性运动，当电机215a带动转盘211停止运动时，可以通过采样针在转动试剂瓶212b和均相试剂瓶212c中吸取固相试剂和均相试剂，以便后续测量和分析。在一些实施例中，两个转盘211每隔固定时间独立交替将其上的目标试剂盒212转送至对应的采样口下方供各自对应的采样针吸取试剂。这样可以进一步降低对转盘211转速的要求，有利于进一步减少对驱动的负载要求，降低驱动控制难度。
对于传统的试剂存储装置10，为了适应高测试通量(单位时间内测试结果的数量)而提高试剂存储容量，通过在一个转盘211上增加安装位以增加 试剂盒212的承载数量，使得该转盘211以及转盘211所承载的试剂盒212的总重量增大，继而使得驱动器215的负载过大，从而导致驱动器215的驱动控制技术难度增大。另外因转盘211的尺寸过大而难以保证自身的加工精度。
而对于上述实施例中的试剂存储装置10，通过在同一锅体100上设置两个存储单元210，即容置腔101中设置有两个转盘211，由于转盘211的数量增加，在单个转盘211的安装位数量保持不变甚至减少的情况下，两个转盘211总的安装位数量增加，使得同样能够增加整个试剂存储装置10中的试剂盒212的承载数量，从而满足测试通量的要求。这样可以保证单个转盘211具有合理的尺寸，从而保证转盘211的加工精度，并且，单个转盘211以及转盘211所承载的试剂盒212的总重量处于合理值范围内，有效防止驱动器215负载过大而导致控制技术难度加大的现象。因此，通过将两个转盘211共用一个锅体100，在增加试剂盒212总数量以适应测量通量的基础上，不仅使得每个转盘211具有相对合理的尺寸，也有利于减少整个试剂存储装置10的体积，使得试剂存储装置10在结构上更加紧凑，同时降低转盘211的运动控制难度。
由于设置两个独立的存储单元210，当其中一个存储单元210出现故障时，另外一个存储单元210可以继续工作，避免传统试剂存储装置10因一个存储单元210出现故障而完全无法工作的现象，从而也提高了整个试剂存储装置10的可靠性和对故障的容忍度。当然，在其中一个存储单元210继续工作的情况下，可以对出现故障的存储单元210进行维修，以便后续恢复两个存储单元210能够同时使用的状态。
同时参阅图1、图2和图7，在一些实施例中，制冷机构300包括冷端单元310、热端单元320、制冷片330、隔热板340和散热风道323，冷端单元310位于容置腔101内，热端单元320和散热风道323位于容置腔101之外。冷端单元310的数量至少为两个，例如冷端单元310的数量为偶数个而划分为一对或多对。至少两个冷端单元310在容置腔101内沿至少两个转盘211 中心的连线或者至少两个转盘211中心连线的垂直中分线呈对称分布。这样不仅有利于提高制冷效率，还有利于保持容置腔101内各点的温度均匀性。在一个实施例中，参阅图5，冷端单元310位于两个转盘211之间的空隙中，沿两个转盘211中心的连线对称分布。这样不仅充分利用了容置腔101内两个转盘211之间的空间，还有利于整机的布局，使得有限的容置腔101能够收容较多的零部件，从而减少整个锅体100的体积。
冷端单元310包括冷端散热片311、冷端风扇312和安装座313，冷端散热片311与制冷片330的冷端连接，紧靠在锅体100的底盖130上安装座313与冷端散热片311连接，冷端风扇312固定在安装座313上。热端单元320包括热端散热片321和热端风扇322，热端散热片321与锅体100的底盖130连接并用于吸收制冷片330热端的热量，热端风扇322的数量为至少两个。当热端风扇322的数量为两个时，两个热端风扇322分别固定在热端散热片321的两端。散热风道323与热端散热片321的端部连接，热端散热片321环绕热端风扇322设置，热端风扇322将热端散热片321的热量从散热风道323排出。对于同一个热端单元320，散热风道323的数量可以为两个，即热端散热片321的两端均连接有一个散热风道323，当然，散热风道323的数量可以为一个，即仅热端散热片321的其中一端连接有散热风道323。散热风道323位于锅体100的下方，这样可以节约锅体100周侧的空间，为整机其他装置的布置留下空间。进一步地，散热风道323位于锅体100中央的下方，从两个驱动器215中间的空隙穿过，这样进一步节约了整个装置的空间。
底盖130上可以开设贯穿孔，隔热板340和制冷片330可以安装在该贯穿孔中，使得隔热板340、制冷片330两者被夹置在热端散热片321和冷端散热片311之间。制冷片330可以为采用半导体材料制成的帕尔贴制冷片330。制冷机构300工作时，制冷片330冷端产生制冷作用，通过冷端散热片311传递至容置腔101内，制冷片330热端的热量传递至热端散热片321上，热端风扇322可以将热量从散热风道323中排出至外界。对于同一对冷端单元310上的冷端风扇322，其吹风风向相反。比如，其中一个冷端单元310上的 冷端风扇312用于从冷端散热片311抽风，另外一个冷端单元310上的冷端风扇312用于向冷端散热片311送风，可以加速容置腔101内气流循环，从而改善容置腔101内的制冷效果，确保容置腔101内的各处空间保证相同的温度，使得试剂盒212中的全部试剂均保持相同的温度。此外，两个转盘211带动其上的试剂盒212独立转动，可以搅动容置腔101内的空气，进一步加速冷空气流动，保持温度均匀性。
由于两个存储单元210共用一个锅体100，使得两个转盘211均位于同一锅体100内的容置腔101中，并且制冷机构300与该锅体100连接，当制冷机构300产生制冷作用而使容置腔101保持设定温度(2-8摄氏度)时，两个转盘211上的试剂盒212都位于相同温度的冷藏环境(容置腔101)内，使得所有试剂盒212中的全部试剂组分均保持相同的温度，从而保证整个试剂存储装置10所存储的试剂的温度一致性，减少因温度不一致而对试剂性能所构成的影响，从而确保后续测试结果的准确性。并且，两个冷端单元310共用相同的散热风道323，可以减少散热风道323的数量，从而使得这个试剂存储结构更加紧凑。再者，冷端单元310位于两个转盘211之间的空隙中，热端散热片321位于冷端散热片311的下方，这样更加有利于热端散热片321和散热风道323的在空间上整体布局。
参阅图7，在一些实施例中，试剂存储装置10还包括扫描器400，扫描器400设置在侧框110的内壁面上，使得扫描器400位于锅体100的容置腔101中，即扫描器400能充分利用容置腔101的现有安装空间，无需占用容置腔101之外的安装空间，从而提高试剂存储装置10在结构上的紧凑性。扫描器400的数量与转盘211的数量可以相等，即每个转盘211对应一个扫描器400。扫描器400用于对试剂盒212上的条码进行扫描，从而识别试剂盒212上的条码信息，以识别和区分不同分析项目的试剂。扫描器400采用固定式设计，即扫描器400直接与侧框110固定连接，这同样会使得试剂存储装置10结构更加紧凑且降低制造成本。
以上所述实施例的各技术特征可以进行任意的组合，为使描述简洁，未 对上述实施例中的各个技术特征所有可能的组合都进行描述，然而，只要这些技术特征的组合不存在矛盾，都应当认为是本说明书记载的范围。
以上所述实施例仅表达了本发明的几种实施方式，其描述较为具体和详细，但并不能因此而理解为对发明专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。因此，本发明专利的保护范围应以所附权利要求为准。

Claims (20)

  1. 一种试剂存储装置，其特征在于，包括：
    锅体，所述锅体开设有容置腔；
    存储机构，所述存储机构包括至少两个存储单元，每个所述存储单元包括位于所述容置腔内的转盘和试剂盒，所述转盘可以在所述容置腔内转动，所述试剂盒设置在所述转盘上并用于存储试剂；及
    制冷机构，所述制冷机构与所述锅体连接以使所述容置腔保持设定温度。
  2. 根据权利要求1所述的试剂存储装置，其特征在于，所述制冷机构包括冷端单元、热端单元和制冷片，所述冷端单元位于所述容置腔内，所述热端单元位于所述容置腔外，所述冷端单元和热端单元的一端分别和制冷片的冷端和热端连接。
  3. 根据权利要求2所述的试剂存储装置，其特征在于，所述冷端单元在所述容置腔内沿至少两个所述转盘中心的连线或者至少两个转盘中心连线的垂直中分线呈对称分布。
  4. 根据权利要求2所述的试剂存储装置，其特征在于，所述冷端单元位于相邻两个所述转盘之间的空隙中，所述冷端单元包括安装座、冷端散热片和冷端风扇，所述安装座设置在所述冷端散热片上，所述冷端风扇设置在所述安装座上。
  5. 根据权利要求4所述的试剂存储装置，其特征在于，所述冷端单元的数量为偶数个而划分为至少一对。
  6. 根据权利要求5所述的试剂存储装置，其特征在于，对于每一对所述冷端单元上的所述冷端风扇，其吹风风向相反。
  7. 根据权利要求2所述的试剂存储装置，其特征在于，所述热端单元包括热端散热片和热端风扇，所述热端散热片与制冷片热端连接并用于吸收所述制冷片热端单元的热量，所述热端散热片的两端均设置有所述热端风扇。
  8. 根据权利要求7所述的试剂存储装置，其特征在于，所述热端单元还包括散热风道，所述散热风道与所述热端散热片的端部连接并环绕所述热端 风扇设置，所述热端风扇将所述热端散热片的热量从所述散热风道排出。
  9. 根据权利要求8所述的试剂存储装置，其特征在于，所述散热风道位于所述锅体的下方。
  10. 根据权利要求1所述的试剂存储装置，其特征在于，所述锅体包括底盖、顶盖和侧框，所述底盖和顶盖分别与所述侧框的两端连接，所述底盖、顶盖和侧框共同围成所述容置腔，所述转盘与所述底盖转动连接，所述制冷机构设置在所述底盖上。
  11. 根据权利要求10所述的试剂存储装置，其特征在于，所述顶盖上设置至少两组采样口，每组所述采样口对应一个所述存储单元。
  12. 根据权利要求10所述的试剂存储装置，其特征在于，所述侧框的横截面形状为长方形或跑道形。
  13. 根据权利要求1所述的试剂存储装置，其特征在于，还包括设置在所述锅体上的扫描器，所述扫描器位于所述容置腔内并用于识别所述试剂盒上的条码信息。
  14. 根据权利要求13所述的试剂存储装置，其特征在于，所述扫描器与所述锅体固定连接。
  15. 根据权利要求1所述的试剂存储装置，其特征在于，所述存储单元还包括环绕所述转盘设置的混匀齿轮，所述试剂盒包括盒体、转动试剂瓶和传动齿轮，所述盒体安装在所述转盘上，所述转动试剂瓶与所述盒体转动连接，所述传动齿轮设置在所述转动试剂瓶上并与所述混匀齿轮啮合。
  16. 根据权利要求1所述的试剂存储装置，其特征在于，每个所述存储单元装载相应分析项目所需的全部试剂。
  17. 根据权利要求1所述的试剂存储装置，其特征在于，所述存储单元还包括转轴和驱动器，所述转轴穿设在所述锅体中并与所述转盘连接，所述驱动器位于容置腔外并驱动所述转轴转动。
  18. 根据权利要求17所述的试剂存储装置，其特征在于，所述驱动器包括电机、主动轮、从动轮和同步带，所述主动轮与所述电机连接，所述从动 轮设置在所述转轴上，所述同步带套设在所述主动轮和所述从动轮上。
  19. 根据权利要求17所述的试剂存储装置，其特征在于，所述制冷机构包括用于排热的散热风道，所述散热风道从两个所述驱动器之间的空隙穿过。
  20. 根据权利要求17所述的试剂存储装置，其特征在于，所述从动轮的直径大于所述主动轮的直径。
PCT/CN2020/087497 2020-04-22 2020-04-28 试剂存储装置 WO2021212537A1 (zh)

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CN108195118A (zh) * 2018-01-31 2018-06-22 深圳迎凯生物科技有限公司 试剂存储装置
CN110967515A (zh) * 2018-09-29 2020-04-07 深圳迎凯生物科技有限公司 试剂盒、试剂盘以及试剂存储装置
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US4906433A (en) * 1986-06-24 1990-03-06 Kabushiki Kaisha Toshiba Automatic chemical analyzer
US20050227360A1 (en) * 2004-04-02 2005-10-13 Devlin William J Sr Method for increasing throughput in an automatic clinical analyzer by duplicating reagent resources
JP2009288094A (ja) * 2008-05-29 2009-12-10 Toshiba Corp 自動分析装置
CN105659070A (zh) * 2013-10-17 2016-06-08 西门子医疗保健诊断公司 紧凑式高容量分析仪器架构
CN108195118A (zh) * 2018-01-31 2018-06-22 深圳迎凯生物科技有限公司 试剂存储装置
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