Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/67—Vitamins
  • A61K8/673—Vitamin B group
  • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/60—Sugars; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/73—Polysaccharides
  • A61K8/731—Cellulose; Quaternized cellulose derivatives
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/73—Polysaccharides
  • A61K8/733—Alginic acid; Salts thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
  • A61K8/86—Polyethers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
  • A61K8/87—Polyurethanes
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin

Definitions

• the present invention relates to an aqueous composition.
• the skin causes pigmentation such as wrinkles, sagging, stains and freckles due to internal factors such as aging and stress, and external factors such as ultraviolet rays and dry air.
• pigmentation such as wrinkles, sagging, stains and freckles due to internal factors such as aging and stress, and external factors such as ultraviolet rays and dry air.
• morphological changes such as wrinkles and sagging and visual changes such as pigmentation greatly affect the impression of appearance, so many people want to improve them, and various products are offered.
• Many active ingredients have been proposed to prevent and improve these wrinkles, sagging and pigmentation.
• niacinamide which is an active ingredient of wrinkles and sagging, is known to have high safety and an anti-aging effect on the skin.
• tranexamic acid as a whitening agent for improving or suppressing pigmentation.
• niacinamide and tranexamic acid have very high crystallinity, and crystal precipitation becomes a problem when they are blended in a formulation or composition such as a cosmetic or an external preparation for skin.
• crystals of niacinamide are formed by blending one or more water-soluble polysaccharides, polyhydric alcohols and monohydric lower alcohols selected from the group consisting of white fungus polysaccharide, sodium chondroitin sulfate and proteoglycan.
• a technique for suppressing precipitation is disclosed (see, for example, Patent Document 1).
• Patent Document 1 does not mention the generation of aggregates due to the combination of niacinamide and the water-soluble polysaccharide. Further, also in the technique of Patent Document 2, there is no mention of the generation of agglomerates due to the combination of tranexamic acid and a water-soluble polysaccharide. As mentioned above, the combination of niacinamide and / or tranexamic acid with water-soluble polysaccharides did not take into account the formation of aggregates and the increase in aggregates over time.
• the present invention uses niacin by using hydrophobic polyether urethane together in an aqueous composition containing one or more active ingredients selected from niacin amide and tranexamic acid or a derivative thereof and a water-soluble polysaccharide. It is an object of the present invention to provide a composition in which aggregation by amide and / or tranexamic acid and a water-soluble polysaccharide is alleviated and an excellent aggregation inhibitory effect is provided.
• aqueous composition using one or more active ingredients selected from niacin amide and tranexamic acid or derivatives thereof, water-soluble polysaccharides and hydrophobic polyether urethane.
• active ingredients selected from niacin amide and tranexamic acid or derivatives thereof, water-soluble polysaccharides and hydrophobic polyether urethane.
• the present invention suppresses the generation of aggregates and the increase of aggregates over time due to the combination of one or more active ingredients selected from niacinamide and tranexamic acid or derivatives thereof and water-soluble polysaccharides. Therefore, it is an aqueous composition characterized by containing the following components (A) to (C). [1] The following components (A) to (C); An aqueous composition containing (A) (a1) niacinamide and (a2) one or more active ingredients selected from tranexamic acid or a derivative thereof (B) water-soluble polysaccharide (C) hydrophobically modified polyether urethane. Is.
• the aqueous composition of the present invention can suppress the generation of aggregates due to the active ingredient selected from niacinamide and tranexamic acid or a derivative thereof and the water-soluble polysaccharide. Further, the aqueous composition of the present invention is excellent in mellowness and non-stickiness at the time of application, and can give a good feeling of use.
• X to Y indicating a range includes X and Y and means "X or more and Y or less”.
• operations and physical properties are measured under the conditions of room temperature (25 ° C.) / relative humidity of 40% RH.
• niacinamide used in the present invention is an amide compound of nicotinic acid (vitamin B3 / niacin).
• Niacinamide is a water-soluble vitamin, a known substance that is one of the B vitamins, and can be extracted from natural products (rice bran, etc.) or synthesized by a known method. Specifically, those listed in the 17th revised Japanese Pharmacopoeia can be used.
• the component (a2) tranexamic acid used in the present invention is a kind of amino acid represented by trans-4- (aminomethyl) cyclohexane-1-carboxylic acid, and has a whitening effect and an anti-inflammatory effect on the skin as described above. In addition to being known as a component having, it may also be used as a hemostatic agent. In the present invention, it is possible to use a derivative of tranexamic acid in place of or in combination with tranexamic acid.
• tranexamic acid Derivatives of tranexamic acid include dimer of tranexamic acid (eg, trans-4- (transaminomethylcyclohexanecarbonyl) aminomethylcyclohexanecarboxylic acid), ester of tranexamic acid and hydroquinone (eg, trans-4).
• dimer of tranexamic acid eg, trans-4- (transaminomethylcyclohexanecarbonyl) aminomethylcyclohexanecarboxylic acid
• ester of tranexamic acid eg, trans-4
• hydroquinone eg, trans-4
• -Aminomethylcyclohexanecarboxylic acid 4'-hydroxyphenyl ester ester of tranexamic acid and gentisic acid (eg 2- (trans-4-aminomethylcyclohexanecarbonyloxy) -5-hydroxybenzoic acid and its Salt), an amide form of tranexamic acid (eg, trans-4-aminomethylcyclohexanecarboxylic acid methylamide and its salt, trans-4- (P-methoxybinzoyl) aminomethylcyclohexanecarboxylic acid and its salt, trans -4-guanidinoaminomethylcyclohexanecarboxylic acid and salts thereof), alkyl esters of tranexamic acid and salts thereof.
• ester of tranexamic acid and gentisic acid eg 2- (trans-4-aminomethylcyclohexanecarbonyloxy) -5-hydroxybenzoic acid and its Salt
• tranexamic acid lauryl ester tranexamic acid myristyl ester, tranexamic acid cetyl ester and tranexamic acid stearyl ester.
• the derivative can be in the form of a salt, and the types are mineral salts such as hydrochloride, phosphate, sulfate, bromine, nitrate; oxalate, lactate, citrate.
• Organic acid salts such as; carbonates and the like.
• tranexamic acid is preferable as a whitening agent that improves or suppresses pigmentation. One or more of these can be used.
• the content of the component (A) in the present invention is not particularly limited, but is 1% by mass (hereinafter, simply “mass%") in the aqueous composition from the viewpoint of the action of the active ingredient and non-stickiness. Is abbreviated as “%") or more, more preferably 2% or more, and even more preferably 5% or more. Further, the content of the component (A) is preferably 10% or less, more preferably 8% or less, and further preferably 7% or less in relation to the feeling of use such as stickiness at the time of application. More preferred.
• (a1) niacinamide and (a2) tranexamic acid or a derivative thereof can be selected from one type or two or more types, but two types are used in combination from the viewpoint of excellent action as an active ingredient. Is more preferable.
• the content of the component (a1) niacinamide is preferably 1% or more, more preferably 2% or more, and even more preferably 3% or more in the aqueous composition. Further, it is preferably less than 10%, more preferably 7% or less, and even more preferably 5% or less from the viewpoint of usability such as non-stickiness.
• the content of the component (a2) tranexamic acid is preferably 1% or more, more preferably 1.5% or more, and even more preferably 2% or more in the aqueous composition. Further, it is preferably less than 10%, more preferably 4% or less, and even more preferably 3% or less from the viewpoint of usability such as non-stickiness.
• the water-soluble polysaccharide is not particularly limited as long as it is usually used for cosmetics, quasi-drugs, pharmaceuticals, etc., but a polysaccharide that forms an elastic gel by swelling with water is preferable.
• examples include agar, carrageenan, pectin, gellan gum, locust bean gum, tamarind gum, xanthan gum, cellulose, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hyaluronic acid, alginic acid and their salts. can do.
• water-soluble polysaccharides can be used alone or in combination of two or more.
• plant-derived polysaccharides such as pectin, locust bean gum, tamarind gum, cellulose, agar, carrageenan, alginic acid, etc. are used rather than using microorganism-derived polysaccharides such as gellan gum and xanthan gum. It may be easier to obtain the aggregation inhibitory effect by using a polysaccharide derived from seaweed or a synthetic polysaccharide.
• mucopolysaccharides such as hyaluronic acid and chondroitin sulfate
• thickening polysaccharides derived from microorganisms such as gellan gum and xanthan gum
• two glucoses in structural units such as gellan gum and xanthan gum.
• the mucopolysaccharide refers to a linear polysaccharide having a repeating structure of disaccharide units of uronic acid and amino sugar.
• the component (B) is a cellulosic water-soluble substance such as methyl cellulose, ethyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose, and hydroxypropyl methyl cellulose from the viewpoint of mellowness and non-stickiness at the time of application.
• Polysaccharides and alginic acid or salts thereof are preferable, among which carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose and hydroxyethyl cellulose are more preferable, and carboxymethyl cellulose, sodium carboxymethyl cellulose and hydroxypropyl methyl cellulose are even more preferable.
• cellulosic water-soluble polysaccharide for example, CMC Daicel (manufactured by Daicel Chemical Co., Ltd.), Metrose 90SH-15000 (manufactured by Shin-Etsu Chemical Co., Ltd.) and the like are commercially available.
• alginic acid or a salt thereof for example, Snow Argin M (manufactured by Fuji Chemical Industry Co., Ltd.) and the like are commercially available.
• the content of the component (B) used in the present invention is preferably 0.1% or more, preferably 0.2% or more in the aqueous composition from the viewpoint of usability such as mellowness at the time of coating. It is more preferable, and it is even more preferable that it is 0.25% or more. Further, from the viewpoint of usability such as non-stickiness, it is preferably 1% or less, more preferably 0.7% or less, and even more preferably 0.5% or less.
• Hydrophobic-modified polyether urethane is an amphipathic copolymer having a hydrophilic base as a skeleton and a hydrophobic portion at the end. Is.
• the component (a) is represented by the following general formula (1).
• R 1 , R 2 and R 4 represent hydrocarbon groups that may be the same or different from each other
• R 3 represents a hydrocarbon group that may have a urethane bond
• R 5 Represents a linear, branched or secondary hydrocarbon group
• m is a number greater than or equal to 2
• h is a number greater than or equal to 1
• k and n are independently numbers in the range 0-1000. It is preferable that R 1 , R 2 and R 4 have 2 to 4 carbon atoms
• R 3 has 1 to 30 carbon atoms
• R 5 has 8 to 36 carbon atoms.
• m is preferably 2
• h is preferably 1
• k is preferably 1 to 500, and more preferably 100 to 300.
• n is preferably 1 to 200, more preferably 10 to 100.
• Hydrophobically modified polyether urethane represented by the general formula (1) may, for example, R 1 - [(O-R 2) k -OH] 1 , two or more polyether polyols and represented by m, R 3 - and one or two or more polyisocyanates represented by (NCO) h + 1, HO- and (R 4 -O) one or more polyether monoalcohols represented by n -R 5 It can be obtained by reacting.
• R 1 to R 5 in the general formula (1) are used R 1 -[( OR 2 ) k- OH] m , R 3- (NCO) h + 1 , HO- (R 4- O). It is determined by the n -R 5.
• both ends of polyethylene glycol have a structure modified with decyltetradecyl alcohol, and the average weight molecular weight is about 5.
• the average weight molecular weight is about 5.
• Examples of commercially available products of such hydrophobically modified polyether urethane include "ADEKANOLT GT-700" (manufactured by ADEKA Corporation), which is a PEG-240 / decyltetradeceth-20 / hexamethylene diisocyanate copolymer.
• the content of the component (C) used in the present invention is preferably 0.1% or more in the aqueous composition from the viewpoint of ensuring the effect of suppressing aggregation while maintaining mellowness at the time of application. It is more preferably 0.2% or more, and even more preferably 0.5% or more.
• the content of the component (C) is preferably 2% or less, preferably 1.5% or less, from the viewpoint of excellent usability such as mellowness and non-stickiness at the time of application and the effect of suppressing aggregation. It is more preferably present, and even more preferably 1% or more.
• the content mass ratio [(A) + (B)] / (C) of the components (A) to (C) is not particularly limited, but is preferably more than 1, preferably 3 or more, and 5 or more. Is more preferable, and 10 or more is even more preferable, and 12 or more and 15 or more are particularly preferable from the viewpoint of the aggregation suppressing effect and the like. Further, the content mass ratio [(A) + (B)] / (C) is 110 or less because it is easy to exhibit non-stickiness and mellowness at the time of application while ensuring the effect of suppressing aggregation. It is preferably 80 or less, more preferably 50 or less, and particularly preferably 35 or less and 24 or less.
• the viscosity of the aqueous composition of the present invention at 25 ° C. is not particularly limited, but is preferably 50 mPa ⁇ s or more, preferably 100 mPa ⁇ s or more, from the viewpoint of mellowness at the time of application and the effect of suppressing aggregation. More preferably. Further, from the viewpoint of usability such as mellowness and non-stickiness at the time of application and the effect of suppressing aggregation, it is preferably 20,000 mPa ⁇ s or less, more preferably 10,000 mPa ⁇ s or less, 5, Even more preferably, it is 000 mPa ⁇ s or less.
• the viscosity in the present invention is such that the one left in a constant temperature bath at 25 ° C. for 24 hours is used, and the rotor is rotated at a speed of 60 rotations per minute using a single cylindrical rotary viscometer (manufactured by Shibaura System Co., Ltd.). It means the value obtained by reading the measured value when rotating for 1 minute and multiplying each multiplier.
• the aqueous composition of the present invention contains any components other than the above components, that is, water, oil, powder, and component (B) contained in ordinary cosmetics and the like as long as the effects of the present invention are not impaired.
• the aqueous composition in which the ratio of the aqueous component in the composition is 90% or more is preferable.
• the aqueous component may be any component that is soluble in water, for example, glycols such as propylene glycol, 1,3-butylene glycol, dipropylene glycol, polyethylene glycol, glycerin, diglycerin, and poly.
• glycols such as propylene glycol, 1,3-butylene glycol, dipropylene glycol, polyethylene glycol, glycerin, diglycerin, and poly.
• examples include glycerols such as glycerin, sugar alcohols such as sorbitol, maltitol and glucose, lower alcohols such as ethanol, moisturizing components such as polyoxyalkylene glycerin ether, polyoxyalkylene diglycerin ether and polyoxyalkylene alkyl glucoside. Be done.
• the water is not particularly limited as long as it is generally used for cosmetics and the like, and examples thereof include purified water, hot spring water, ion-exchanged water, deep water, tap water, steam distilled water of plants and the like. If necessary, one type or two or more types can be appropriately selected and used.
• the oil agent is not particularly limited as long as it is generally used for cosmetics and the like, and examples thereof include higher alcohols, hydrocarbon oils, ester oils, waxes and silicone oils.
• the content of the oil agent in the present invention is not particularly limited, but is preferably 3% or less, more preferably 1% or less in the aqueous component. Within this range, an aqueous composition having excellent mellowness and non-stickiness at the time of application can be obtained.
• the aqueous composition of the first embodiment of the present invention may be used as it is as the final form of the cosmetic or skin external preparation, or the aqueous composition may be mixed as another component to make a cosmetic or skin external preparation. May be. That is, the second embodiment is a cosmetic or an external preparation for skin containing the aqueous composition of the first embodiment.
• the cosmetic or external preparation for skin of the second embodiment tends to exert the effects of the aqueous composition, such as mellowness and non-stickiness at the time of application, and an effect of suppressing aggregation.
• the dosage form of the cosmetic or external preparation for skin containing the aqueous composition of the present invention is not particularly limited, but water-based, solubilized type, oil-in-water type, water-in-water type, multi-layer type and the like can be used. It is preferable that it is an aqueous type, a solubilized type and an oil-in-water type.
• the properties of the cosmetic or skin external preparation containing the aqueous composition of the present invention can be implemented in various forms such as liquid, gel, cream and mousse, and among them, liquid. It is preferable to obtain the effect of the present invention.
• the liquid means a state having fluidity at 25 ° C.
• the viscosity measured using a Brookfield type rotational viscometer is 20,000 mPa ⁇ s or less, preferably 10,000 mPa ⁇ s or less, more preferably 5,000 mPa ⁇ s or less. Refers to something.
• the aqueous composition of the present invention can be used for cosmetics.
• cosmetics for example, lotion, milky lotion, cream, beauty liquid, massage cosmetics, pack cosmetics, hand cream, body lotion, body cream, makeup cosmetics, makeup base cosmetics, eye cream, sunscreen, hair cream, hair Skin care cosmetics are preferable in that they are suitable as waxes and the like and the effects can be felt, and the methods of use are as follows: hands, fingers, cotton, impregnation with non-woven fabrics, etc., and direct spraying. The method to be used and the like can be mentioned.
• the aqueous composition of the present invention can also be used as an external preparation for skin.
• an external liquid agent, an external gel agent, a cream agent, an ointment agent, a liniment agent, a lotion agent, a hap agent, a plaster agent, a spray agent, an aerosol agent and the like can be mentioned.
• the usage method can be mentioned in the same manner as the above-mentioned cosmetics.
• the method for producing the aqueous composition of the present invention is not particularly limited, and is prepared by a conventional method.
• it can be produced by dissolving or dispersing the above components (A) to (C) and, if necessary, the above optional components in water to form an aqueous composition or an oil-in-water emulsion, for example, a homomixer or the like. It can be manufactured using a high-pressure emulsifier.
• the present invention can also be configured as a method of suppressing the generation of agglomerates in a mixture of the component (A) and the component (B) by using the component (C).
• the procedure of mixing the components (A) to (C) in a coexisting state, the procedure of adding the component (C) to the mixture of the component (A) and the component (B), and the component The procedure for adding a mixture of the component (A) and the component (B) to (C), and mixing the component (C) with one of the component (A) and the component (B), and then the component (A) and Any method can be carried out, such as the procedure of adding the remaining other of the component (B).
• the procedure for adding the component (C) to the mixture of the component (A) and the component (B) and the component (A) and the component (B) to the component (C). ) The procedure of mixing the component (C) and the component (B), and then the procedure of adding the component (A) are preferably used. Further, in the method of the present invention, specifically, all of the component (B), all of the component (C), and all or a part of any component are uniformly dissolved and mixed at 70 to 80 ° C. and 30 to 40 ° C.
• the second mixture may be prepared and then mixed by adding the first mixture to the second mixture at room temperature (25 ° C.).
• a usage test was conducted by 20 cosmetics evaluation specialist panels, and 1.5 g of each sample was applied to the entire face, and each panel member applied it.
• the following absolute evaluation was used to evaluate and score on a 5-point scale, and the average value was calculated from the total score of all the panels of each sample, and the results were judged according to the following 3-step criteria. ⁇ If it is above, it is practically acceptable.
• (Evaluation method 2) B Non-stickiness
• a usage test was conducted by 20 cosmetics evaluation panel, and after 1.5 g of each sample was applied to the entire face, each panel immediately after that, regarding the stickiness.
• the following absolute evaluation was used to evaluate and give a score, and the average value was calculated from the total score of all the panels of each sample, and the judgment was made according to the following four-stage judgment criteria. If it is ⁇ or more, it is practically acceptable.
• the aqueous compositions of Examples 1 to 19 of the present invention have a mellowness at the time of application, no stickiness, and an effect of suppressing aggregation as compared with the aqueous compositions of Comparative Examples 1 to 5. It was also excellent.
• Example 20 Toner (ingredient) (% by mass) (1) Niacinamide (component (a1)) 4 (2) Tranexamic acid (ingredient (a2)) 3 (3) Sodium monohydrogen phosphate 0.02 (4) Sodium dihydrogen phosphate 0.02 (5) Sodium metabisulfite 0.003 (6) Purified water 20 (7) Methyl paraoxybenzoate 0.1 (8) Disodium edetate 0.05 (9) Fragrance 0.2 (10) Ethanol 10 (11) Phenoxyethanol 0.2 (12) Polyoxyethylene hydrogenated castor oil isostearate Note 5 0.1 (13) Polyoxyethylene polyoxypropylene decyltetradecyl ether Note 6 0.1 (14) 1,3-butylene glycol 10 (15) Glycerin 5 (16) Dipropylene glycol 5 (17) Diglycerin 0.5 (18) Remaining amount of purified water (19) (PEG-240 / decyltetradeceth-20 / HDI) Copolymer (Component (C))
• Example 20 (Production method) A: Ingredients (1) to (8) are uniformly dissolved and mixed at room temperature. B: Ingredients (9) to (13) are uniformly dissolved and mixed at room temperature. C: Ingredients (14) to (20) are uniformly dissolved and mixed at 70 ° C. D: Add A to C cooled to 40 ° C. and mix. Toner obtained by adding and mixing B with E: D The lotion of Example 20 obtained as described above is excellent in all of the mellowness at the time of application, the non-stickiness, and the effect of suppressing aggregation. there were. The mass ratio of the components (A) to (C) [(A) + (B)] / (C) was 15.
• Example 21 Oil-in-water emulsion (ingredient) (% by mass) (1) 1,3-butylene glycol 5 (2) Glycerin 5 (3) Remaining amount of purified water (4) Polyethylene glycol monostearate (40EO) 0.5 (5) Sorbitan sesquioleate 0.1 (6) Hydrogenated soybean phospholipid Note 7 0.2 (7) Cholesterol Note 8 0.1 (8) Tri (caprylic acid / caprylic acid) glyceryl 1 (9) ⁇ -olefin oligomer 1 (10) Macademia nut oil fatty acid phytosteryl Note 9 0.5 (11) Vaseline 0.5 (12) Dimethylpolysiloxane (10CS) 0.5 (13) Setostearyl alcohol 1 (14) Behenyl alcohol 0.5 (15) Methyl paraoxybenzoate 0.1 (16) Carboxyvinyl polymer 0.2 (17) (PEG-240 / decyltetradeceth-20 / HDI) Copolymer (Component (C)) Note
• Example 22 Beauty essence (underwater oil type) (Ingredient) (%) (1) 1,3-butylene glycol 5 (2) Dipropylene glycol 5 (3) Remaining amount of purified water (4) Polyoxyethylene sorbitan monooleate (20EO) 0.1 (5) Polyethylene glycol monostearate (55EO) 0.25 (6) Hydrogen lecithin Note 11 0.1 (7)
• Meadowfoam oil 1 (8) Liquid paraffin 2 (9) Setostearyl alcohol 0.5 (10) Methyl paraoxybenzoate 0.1 (11) (Acrylate / Alkyl Acrylate (C10-30)) Cross polymer Note 12 0.02 (12) (PEG-240 / decyltetradeceth-20 / HDI) Copolymer (Component (C)) Note 1 0.5 (13) Na alginate (component (B)) Note 4 0.5 (14) Sodium hydroxide 0.01 (15) Niacinamide (component (a1)) 4 (16) Tranexamic acid (ingredient (a2)
• Example 23 Sunscreen (underwater oil type) (Ingredient) (%) (1) 1,3-butylene glycol 5 (2) Glycerin 5 (3) Remaining amount of purified water (4) Behentrimonium chloride 0.1 (5) Hydrogenated lecithin Note 11 0.5 (6) Cholesterol Note 8 0.6 (7) Phytosterol 0.1 (8) Dimethicodiethylbenzalmalonate 1.2 (9) 4-tert-Butyl-4'-methoxy-dibenzoylmethane 2 (10) 2-ethylhexyl paramethoxycinnamate 7 (11) Diethylaminohydroxybenzoyl hexyl benzoate 2.5 (12) Stearic acid hardened castor oil Note 14 1 (13) Propylene Glycol Dicaprate 5 (14) Ethyl oleate 0.3 (15) (Acrylic acid / Alkyl acrylate (C10-30)) Copolymer Note 13 0.4 (16) (PEG-240 / decylte
• A The components (1) to (3) are uniformly dissolved and mixed at 75 ° C.
• B Ingredients (4) to (14) are uniformly dissolved and mixed at 75 ° C.
• C The B is added to the A and emulsified at 70 ° C.
• D Ingredients (15) to (29) were added to and mixed with C, and then cooled to 40 ° C. to obtain a sunscreen (oil-in-water type).
• the sunscreen agent (oil-in-water type) of Example 23 obtained as described above was excellent in all of the mellowness at the time of application, the non-stickiness, and the effect of suppressing aggregation.
• the mass ratio of the components (A) to (C) [(A) + (B)] / (C) was 95.

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• 2021
  • 2021-03-31 KR KR1020227033940A patent/KR20220161335A/ko active Pending
  • 2021-03-31 CN CN202180025191.5A patent/CN115335032A/zh active Pending
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• 2024
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