WO2021192638A1 - Ensemble tube externe, seringue et instrument d'administration de médicament liquide - Google Patents

Ensemble tube externe, seringue et instrument d'administration de médicament liquide Download PDF

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Publication number
WO2021192638A1
WO2021192638A1 PCT/JP2021/003899 JP2021003899W WO2021192638A1 WO 2021192638 A1 WO2021192638 A1 WO 2021192638A1 JP 2021003899 W JP2021003899 W JP 2021003899W WO 2021192638 A1 WO2021192638 A1 WO 2021192638A1
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WO
WIPO (PCT)
Prior art keywords
outer cylinder
needle
tip
syringe
cylinder assembly
Prior art date
Application number
PCT/JP2021/003899
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English (en)
Japanese (ja)
Inventor
二三也 松本
昌史 竹本
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Priority to JP2022509348A priority Critical patent/JPWO2021192638A1/ja
Publication of WO2021192638A1 publication Critical patent/WO2021192638A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced

Definitions

  • the present invention relates to an outer cylinder assembly, a syringe, and a drug solution administration tool.
  • a syringe has been used to quantitatively distribute a liquid drug (drug solution).
  • drug solution drug solution
  • examples of this type of syringe include an insulin injector for injecting insulin, which is a liquid drug for the treatment of diabetes.
  • insulin injector for injecting insulin
  • Some diabetics need to operate the syringe themselves to administer insulin several times a day, repeating daily, and the pain caused by needle puncture during this drug solution (self-injection) is a major problem. It has become.
  • Patent Document 1 Japanese Patent Laid-Open No. 2002-159576
  • Patent Document 2 Japanese Patent Laid-Open No. 2002-291884.
  • a needle whose outer diameter is narrower at the tip and thicker from the tip to the base end, and the inner diameter is changed accordingly.
  • Patent Document 3 Japanese Patent Laid-Open No. 2005-087519 discloses a drug solution injection device provided with a plurality of relatively thin needles in order to secure an injection amount of the drug solution while reducing pain.
  • JP-A-2002-159576 (US2002-052580A1, US2005-096603A1) JP-A-2002-291884 (US2004-07800A1) Japanese Unexamined Patent Publication No. 2005-087519
  • the injection needle in order to alleviate the pain caused by the puncture of the injection needle, the injection needle is shallowly punctured at a plurality of puncture sites (arm, abdomen, buttocks, etc.) in advance. It turned out that some patients were looking for areas with relatively little pain. However, such "trial puncture” may cause blood or tissue fluid to adhere to the tip of the needle, which may cause hygienic problems. Therefore, according to the present invention, it is possible to search for a puncture site with relatively little pain (so-called "trial puncture”) without directly puncturing the injection needle, and a more hygienic outer cylinder assembly, syringe and drug solution administration tool. Is to provide.
  • An outer cylinder including an outer cylinder main body and a needle fixing portion provided at the tip of the outer cylinder main body, and a puncture needle tip at the tip, and a base end portion at the needle fixing portion of the outer cylinder.
  • An outer cylinder assembly comprising a needle-attached syringe outer cylinder having a fixed injection needle and a tubular protective member attached to the tip of the needle-attached syringe outer cylinder.
  • the protective member wraps the tip side portion of the outer cylinder for a syringe with a needle including the puncture needle tip so as to be projectable, and the outer cylinder assembly is the puncture needle tip of the injection needle.
  • An outer cylinder assembly having a protrusion for skin contact that is located closer to the tip and projects toward the tip.
  • An outer cylinder including an outer cylinder main body and a needle fixing portion provided at the tip of the outer cylinder main body, and a puncture needle tip at the tip, and a base end portion at the needle fixing portion of the outer cylinder.
  • An outer cylinder assembly comprising a needle-attached syringe outer cylinder having a fixed injection needle and a seal cap attached to the outer cylinder so as to seal the puncture needle tip of the injection needle.
  • the outer cylinder assembly includes a contact member that is located on the tip side of the injection needle with respect to the tip of the puncture needle and has a skin contact protrusion that protrudes toward the tip, and the contact member. Is an outer cylinder assembly that can be detached from the outer cylinder or that the skin contact protrusion on the contact member can rotate in the direction of the base end or side of the outer cylinder.
  • a gasket that is housed in the outer cylinder assembly, the outer cylinder for the syringe with a needle of the outer cylinder assembly, and is slidable in the outer cylinder for the syringe with a needle in a liquid-tight state, and the gasket.
  • a syringe consisting of a plunger for pressing.
  • a gasket that is housed in the outer cylinder assembly, the outer cylinder for the syringe with a needle of the outer cylinder assembly, and is slidable in the outer cylinder for the syringe with a needle in a liquid-tight state, and the gasket.
  • a drug solution administration tool comprising a plunger for pressing a syringe and a medical liquid filled in the outer cylinder for a syringe with a needle.
  • FIG. 1 is a front view showing an embodiment of the drug solution administration tool of the present invention.
  • FIG. 2 is a front sectional view of the drug solution administration tool shown in FIG.
  • FIG. 3 is an explanatory view of an enlarged cross section of a portion B in FIG.
  • FIG. 4 is an enlarged explanatory view of part A in FIG.
  • FIG. 5 is an explanatory view in the C direction in FIG.
  • FIG. 6 is an explanatory diagram for explaining how to use the drug solution administration tool shown in FIG.
  • FIG. 7 is an explanatory diagram for explaining how to use the drug solution administration tool shown in FIG.
  • FIG. 8 is a front explanatory view showing another embodiment of the drug solution administration tool of the present invention.
  • FIG. 9 is a front sectional explanatory view of the chemical solution administration tool shown in FIG.
  • FIG. 10 is an explanatory view in the D direction in FIG.
  • FIG. 11 is an enlarged cross-sectional explanatory view of part E in FIG.
  • FIG. 12 is an explanatory view in the F direction in FIG. 10 for explaining the first guide path.
  • FIG. 13 is an explanatory view in the G direction in FIG. 10 for explaining the second guide path.
  • FIG. 14 is a front explanatory view showing another embodiment of the drug solution administration tool of the present invention.
  • FIG. 15 is a front explanatory view showing another embodiment of the drug solution administration tool of the present invention.
  • FIG. 16 is a front explanatory view showing another embodiment of the drug solution administration tool of the present invention.
  • FIG. 17 is a front explanatory view showing another embodiment of the drug solution administration tool of the present invention.
  • the outer cylinder assembly of the present invention the syringe provided with the outer cylinder assembly, and the drug solution administration tool will be described with reference to the examples shown in the drawings.
  • the upper side (upper direction) in FIG. 1 is the tip side (tip direction)
  • the lower side (lower direction) in FIG. 1 is the base end side (base end direction)
  • the vertical direction in FIG. Will be described as the axial direction.
  • the outer cylinder assembly 3 of the present invention has an outer cylinder 31 including an outer cylinder main body 33, a needle fixing portion 34 provided at the tip of the outer cylinder main body 33, and a puncture needle tip 35 at the tip.
  • An outer cylinder 30 for a syringe with a needle having an injection needle 32 whose base end is fixed to a needle fixing portion 34 of the outer cylinder 31 and a tubular shape attached to the tip of the outer cylinder 30 for a syringe with a needle.
  • a protective member 40 is provided.
  • the protective member 40 encloses the tip end side portion of the outer cylinder 30 for a syringe with a needle including the puncture needle tip 35 so as to protrude, and the outer cylinder assembly 3 includes the puncture needle tip 35 of the injection needle 32. It is provided with a skin contact protrusion 41 that is located closer to the tip and projects toward the tip.
  • the drug solution administration tool 1 of the present invention is housed in the above-mentioned outer cylinder assembly 3 and the outer cylinder 30 for a syringe with a needle of the outer cylinder assembly 3, and the inside of the outer cylinder 30 for a syringe with a needle is in a liquid-tight state.
  • a slidable gasket 21, a plunger 22 for pressing the gasket 21, and a medical liquid 11 filled in the outer cylinder 30 for a syringe with a needle are provided.
  • the syringe 2 of the present invention is housed in the above-mentioned outer cylinder assembly 3 and the outer cylinder 30 for a syringe with a needle of the outer cylinder assembly 3, and the inside of the outer cylinder 30 for a syringe with a needle is in a liquid-tight state. It is composed of a slidable gasket 21 and a plunger 22 for pressing the gasket 21.
  • the outer cylinder 31 of the outer cylinder 30 for a syringe with a needle has an outer cylinder main body 33, a needle fixing portion 34 provided at the tip of the outer cylinder main body 33, and an outer cylinder 31.
  • a flange 36 provided at the base end of the cylinder body 33 and projecting outward (direction orthogonal to the axial direction) is provided.
  • the outer cylinder body 33 is a transparent or semi-transparent substantially tubular portion. Further, the needle fixing portion 34 protrudes in the tip direction from the tip end portion of the outer cylinder body portion 33 (in this embodiment, a shoulder portion formed at the tip end of the outer cylinder body portion 33 and whose diameter is reduced toward the tip end direction). At the same time, it has a hollow cylindrical shape having a diameter smaller than that of the outer cylinder main body 33. Further, as shown in FIGS. 2 and 3 (shown except for some configurations), the needle fixing portion 34 is provided at the annular head 37 provided at the tip and at the base end of the annular head 37.
  • the annular head 37 is formed with a recess recessed from the tip surface toward the proximal end side and a hollow conical portion located in the recess and having an apex on the distal end side.
  • the annular head 37 may have a hollow cylindrical shape (cylindrical shape) in which the recess and the conical portion are omitted.
  • the annular recess (reduced diameter portion) may not be tapered, but may have a shape that is simply reduced in diameter so that a step is formed between the base end of the annular head 37 and the connecting portion 39.
  • a plurality of grooves extending in the axial direction of the outer cylinder 31 are formed on the outer surface of the connecting portion 39.
  • the connecting portion 39 also has a function of increasing the fixing strength of the injection needle 32, but if the fixing strength can be obtained even if the connecting portion 39 is omitted, the base end portion of the annular recess (tapered diameter-reduced portion 38) is obtained. And the tip end portion of the outer cylinder main body 33 may be directly connected.
  • plastic for example, polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly- (4). -Methylpentene-1), acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyester such as polyethylene terephthalate, cyclic olefin polymer, various resins such as cyclic olefin copolymer, among them, easy to mold and transparent. Resins such as polypropylene, cyclic olefin polymers, and cyclic olefin copolymers are preferable because they are excellent in quality, have no effect on chemicals, and have heat resistance.
  • the injection needle 32 As the injection needle 32, a hollow one having a puncture needle tip 35 at the tip is used. The base end portion of the injection needle 32 is inserted and fixed in the hollow portion of the needle fixing portion 34, and the inside of the injection needle 32 communicates with the internal space of the outer cylinder 31 (outer cylinder main body 33). ..
  • a material for forming the injection needle 32 a metal is generally used. As the metal, stainless steel is preferable.
  • the injection needle 32 is fixed to the outer cylinder 31 so as not to be detachable.
  • the injection needle 32 is inserted into the hollow portion of the needle fixing portion 34 of the outer cylinder 31 which is molded in advance, and the needle is formed by adhesive, heat welding, or the like. It may be fixed to the fixing portion 34. Further, the injection needle 32 may be fixed by directly insert molding the injection needle 32 into the outer cylinder 31.
  • the needle fixing portion 34 becomes a tubular shape (hollow shape) into which the injection needle 32 is inserted, and the base end portion of the injection needle 32 is the needle fixing portion 34. It is inserted and fixed in the hollow part.
  • the injection needle 32 is fixed to the outer cylinder 31 by fusing (for example, heat fusing, ultrasonic fusing, laser fusing, induction heating fusing) using a tubular member made of a thermoplastic resin. It may be the one that has been used.
  • fusing for example, heat fusing, ultrasonic fusing, laser fusing, induction heating fusing
  • the outer cylinder 31 a cylinder having a hollow tip portion having a lumen portion capable of accommodating a tubular member made of a thermoplastic resin is used.
  • the thermoplastic resin tubular member a member having a communication hole capable of accommodating the base end portion of the injection needle is used.
  • thermoplastic resin tubular member into which the base end of the injection needle is inserted is inserted into the hollow tip of the outer cylinder, and the thermoplastic resin tubular member is directly or indirectly heated and melted.
  • the injection needle is fixed to the outer cylinder via a thermoplastic resin tubular member.
  • the injection needle 32 of this embodiment is a thin straight injection needle extending from the tip end to the base end with substantially the same outer diameter and inner diameter.
  • the present invention is not limited to such a case, and for example, in order to reduce the puncture resistance (to reduce the pain caused to the patient at the time of puncture), the tip side portion including the puncture needle tip 35 (insertion at the time of puncture).
  • a tapered portion holding injection needle whose outer diameter is smaller than the outer diameter of the proximal end side portion) may be used.
  • a tapered injection needle whose outer shape on the proximal end side is larger than the outer diameter of the distal end side portion including the puncture needle tip 35 is used.
  • a part of the injection needle from the tip to the proximal end may be a tapered portion, and the tapered portion is formed over the entire length from the distal end to the proximal end. It may be a thing.
  • a tubular protective member 40 is attached to the tip of the outer cylinder 30 for a syringe with a needle.
  • the protective member 40 has a substantially cylindrical shape in which the inner shape (inner diameter) is larger than the tip end side portion of the outer cylinder 30 for a syringe with a needle (the outer cylinder main body 33 of the outer cylinder 31). It has a sufficient axial length to cover the tip end side portion including the puncture needle tip 35 of the outer cylinder 30 for a syringe with a needle.
  • a tip annular wall portion 43 projecting inward in the radial direction is formed at the tip of a substantially cylindrical side wall portion 42, and the inner peripheral surface of the side wall portion 42 and the proximal end side surface of the tip annular wall portion 43.
  • a step portion 44 is formed between the two.
  • the inner peripheral surface of the tip annular wall portion 43 forms a tip opening through which the injection needle 32 can protrude (exposed to the outside) at the time of puncture.
  • the outer cylinder assembly 3 includes an urging member 45 that urges the protective member 40 toward the tip end relative to the outer cylinder 30 for a syringe with a needle.
  • the urging member 45 is arranged between the protective member 40 and the collar member 46, which will be described later, attached to the tip of the outer cylinder 30 for a syringe with a needle.
  • a coil spring is used as the urging member 45.
  • the collar member 46 is rotatably and non-movably attached around the needle fixing portion 34 of the needle-attached syringe outer cylinder 30 (outer cylinder 31).
  • the collar member 46 has a small diameter portion 47 provided on the tip end side and a large diameter portion 48 provided on the proximal end side.
  • a step portion 49 is formed between the outer peripheral surface of the small diameter portion 47 and the front end side surface of the large diameter portion 48.
  • a mounting hole 50 for inserting and mounting the needle fixing portion 34 is provided inside the collar member 46 (small diameter portion 47 and large diameter portion 48).
  • the inner surface of the mounting hole 50 is formed in a tapered shape that gradually narrows toward the tip end.
  • an engaging convex portion 51 projecting inward in the radial direction is provided.
  • the engaging convex portion 51 engages with the annular concave portion (tapered diameter-reduced portion 38) of the needle fixing portion 34 in a state where the collar member 46 is attached to the needle-attached syringe outer cylinder 30.
  • the collar member 46 is made immovable in the axial direction with respect to the needle fixing portion 34 (outer cylinder 30 for syringe with needle).
  • the small diameter portion 47 is formed with a plurality of notches (slits) extending in the axial direction in order to facilitate attachment of the collar member 46 to the outer cylinder 30 for a syringe with a needle (needle fixing portion 34). May be good.
  • the urging member (coil spring) 45 has its base end abutting (preferably fixed) on the step portion 49 of the collar member 46, and the tip end portion on the step portion 44 of the protective member 40. It is in contact (preferably fixed).
  • the urging member 45 urges the collar member 46, which is attached to the outer cylinder 30 for a syringe with a needle so as not to move in the axial direction, and the protective member 40 in a direction in which they are separated from each other.
  • the urging member 45 urges the protective member 40 toward the tip of the outer cylinder 30 for a syringe with a needle.
  • the urging member 45 is fixed to the collar member 46 and the protective member 40, and the protective member 40 is separated from the needle-attached syringe outer cylinder 30 by the urging force of the urging member 45. It is designed not to be done.
  • An engaging mechanism or the like that regulates the relative movement amount of the above may be provided.
  • a skin contact protrusion 41 is formed at the tip of the protective member 40. More specifically, as shown in FIGS. 2, 4 and 5, in the outer cylinder assembly 3, the protective member 40 has a cylindrical shape, and the skin contact protrusion 41 is the tip of the protective member 40. A plurality (here, eight) are formed in the circumferential direction on the surface (the tip side surface of the tip annular wall portion 43). In this embodiment, the number of skin contact protrusions 41 is preferably 2 to 10, and particularly preferably 3 to 8. Further, the plurality of skin contact protrusions 41 are provided with respect to the central axis of the protective member 40. It is preferable that they are provided at equal angles.
  • the protrusion height of the skin contact protrusion 41 is preferably 0.1 to 0.6 mm, and particularly preferably 0.3 to 0.5 mm.
  • Each skin contact protrusion 41 has a conical shape that protrudes so as to be convex toward the tip.
  • the shape of the skin contact protrusion 41 is not limited to a cone, and may be, for example, a polygonal pyramid shape such as a triangular pyramid or a quadrangular pyramid, or a needle shape. It is desirable that the skin contact protrusion 41 abuts on the patient's skin to cause a predetermined irritation (pain). It is preferable that the skin contact protrusion 41 does not damage the skin even if it is brought into contact with the skin with a certain force.
  • the gasket 21 housed in the outer cylinder 30 for a syringe with a needle is made of elastic rubber or synthetic resin.
  • the gasket 21 includes a substantially cylindrical main body portion extending with substantially the same outer diameter and a plurality of annular ribs provided on the outer surface of the main body portion, and the outer surface of the annular ribs is formed. It comes into liquid-tight contact with the inner surface of the outer cylinder 30 for a syringe with a needle (outer cylinder main body 33), and can slide in a liquid-tight state.
  • Examples of the material for forming the gasket 21 include elastic rubber (for example, butyl rubber, latex rubber, silicone rubber, etc.), synthetic resin (for example, styrene elastomer such as SBS elastomer and SEBS elastomer, ethylene- ⁇ olefin copolymer elastomer, etc.). It is preferable to use an olefin-based elastomer or the like.
  • the plunger 22 for pressing the gasket 21 is made of a hard or semi-hard resin.
  • the plunger 22 has a small disk-shaped gasket pressing portion provided at the tip, a disk-shaped pressing operating portion provided at the base end, and a cross-section cross. It is provided with a shaft portion extending in the axial direction of the outer cylinder 30 for a syringe with a needle between the gasket pressing portion and the pressing operation portion.
  • the shaft portion may be a columnar shaft.
  • the columnar shaft may have a rod shape, a columnar shape, a polygonal columnar shape, a cylindrical shape, a polygonal tubular shape, or the like.
  • the plunger 22 is connected to the gasket 21 at the tip portion (gasket pressing portion).
  • a hard or semi-hard resin such as high-density polyethylene, polypropylene, polystyrene, or polyethylene terephthalate.
  • the tip of the injection needle 32 communicated with the internal space of the outer cylinder 31 (outer cylinder main body 33) is sealed by the seal cap 12 and has a needle.
  • the leakage of the medical liquid 11 stored in the outer cylinder 30 for the syringe is prevented, and the unintended exposure of the puncture needle tip 35 is prevented.
  • the material for forming the seal cap 12 synthetic rubber such as natural rubber, isoprene rubber, butyl rubber, butadiene rubber, fluororubber, and silicone rubber, and elastic material such as thermoplastic elastomer such as olefin elastomer and styrene elastomer are preferable.
  • the seal cap 12 is made of an elastic material as described above, and the distal end side portion is solid and the proximal end side portion is hollow to form a proximal end opening.
  • the tip portion of the seal cap 12 protrudes from the tip opening of the protective member 40 (tip annular wall portion 43), and the tip portion has an enlarged diameter and is in contact with the tip surface of the protective member 40.
  • the base end portion (base end opening) of the seal cap 12 is elastically deformed to the annular head 37 of the needle fixing portion 34 (a state in which the base end opening expands according to the outer shape of the annular head 37). Fit.
  • the inner surface of the base end opening of the seal cap 12 is in close contact with the outer surface of the annular head 37 of the needle fixing portion 34, and the seal cap 12 is prevented from being unintentionally detached from the outer cylinder 30 for the syringe with a needle. Will be done.
  • the seal cap may be any seal cap as long as it can be sealed and can be removed without damaging the needle tip of the injection needle.
  • the medical liquid 11 is stored (filled) in the outer cylinder 30 for a syringe with a needle (in the space formed between the seal cap 12 and the gasket 21). There is.
  • Various medical liquids 11 can be used as the medical liquid 11 (liquid drug) to be filled in the outer cylinder 30 for a syringe with a needle, and for example, a small amount of a protein preparation, an antibody preparation, hyaluronic acid, insulin, etc.
  • Medical liquids that require self-injection are preferably used.
  • examples of antidote with such medical fluids are insulin pens for diabetics, epinephrine for food and insect bite allergies, and exposure to chemical and / or biological toxins on the battlefield. Examples include antidotes for soldiers who may be vulnerable.
  • the seal cap 12 removes from the drug solution administration tool 1.
  • the user can remove the seal cap 12 by pinching the tip (diameter-expanded portion) of the seal cap 12 protruding from the tip opening of the protective member 40 (tip annular wall portion 43) and pulling it out toward the tip. ..
  • the tip side portion of the outer cylinder 30 for a syringe with a needle including the puncture needle tip 35 is punctured by a protective member 40 urged in the tip direction by the urging member 45.
  • the injection needle 32 including the tip 35 is wrapped so as not to be exposed to the outside.
  • the user searches for a puncture site using a plurality of skin contact protrusions 41 formed on the tip surface of the protective member 40.
  • a plurality of skin contact protrusions 41 formed on the tip surface of the protective member 40 form a puncture needle tip 35 of the injection needle 32. It is located closer to the tip and protrudes toward the tip. Therefore, the user searches for a relatively painless site (low pain site) by pressing the skin contact protrusion 41 against a plurality of puncture sites (arms, abdomen, buttocks, etc.) 100 (so-called).
  • “Trial stab" can be done.
  • the protective member 40 When performing a trial stab, it is desirable to hold the protective member 40.
  • the outer cylinder 30 for a syringe with a needle resists the urging force of the urging member 45 against the protective member 40. It is necessary to be careful not to project (expose) the puncture needle tip 35 from the tip (tip opening) of the protective member 40 by moving toward the tip.
  • a plurality of skin contact protrusions 41 are formed on the tip surface of the protective member 40 in the circumferential direction. More specifically, the plurality of skin contact protrusions 41 form an injection needle 32 (puncture needle tip 35) on the annular tip surface of the protective member 40 (tip annular wall portion 43) when viewed from the axial tip side. ) Are formed at equal intervals on the concentric circumference. Therefore, it is possible to accurately search for a desired low pain site, and it is possible to reduce an error from the actual puncture site (the site where the puncture needle tip 35 is actually punctured by an operation described later). In addition, by giving stimulation by contact of a plurality of skin contact protrusions 41 to a certain area around the puncture site in advance, pain during actual puncture is reduced (pain is less likely to be felt). There is also an effect.
  • the outer cylinder 30 for a syringe with a needle is moved toward the tip (toward the puncture site), and the injection needle 32 (puncture needle) is moved to the desired puncture site (the found low pain site).
  • the tip 35) is punctured.
  • the puncture needle tip 35 of the injection needle 32 is punctured (preferably) by holding the protective member 40 in a fixed position and moving the outer cylinder 30 for a syringe with a needle toward the tip in a state where the puncture site is determined.
  • the injection needle 32 is punctured at the puncture site by reaching the skin) and further pushing it.
  • the plunger 22 is operated to administer (inject) the medical liquid 11 into the body.
  • the drug solution administration tool 1 After administration of the medical liquid 11, the drug solution administration tool 1 is removed from the puncture site. At this time, the protective member 40 is moved toward the tip by the urging force of the urging member 45, and the injection needle 32 including the puncture needle tip 35 is not exposed to the outside again. Cover the tip side part. Therefore, the puncture needle tip 35 is prevented from being exposed to the outside after puncture, which is more hygienic.
  • the outer cylinder assembly 3 of this embodiment is attached to the outer cylinder 30 for a syringe with a needle and the tip (needle fixing portion 34) of the outer cylinder 30 for a syringe with a needle, and is used for puncturing the outer cylinder 30 for a syringe with a needle. It is provided with a protective member 40 that wraps the tip end side portion including the needle tip 35 so as to be projectable, and is further located on the tip end side of the puncture needle tip 35 of the injection needle 32 and projects toward the tip end direction. A protrusion 41 for contacting the skin is provided.
  • the skin contact protrusion 41 does not directly puncture the injection needle 32 for comparison. It is hygienic because it is possible to search for a low pain area with less target pain (so-called "trial puncture").
  • the drug solution administration tool 10 (syringe 20) has a configuration substantially similar to that of the drug solution administration tool 1 (syringe 2) described above, by using the same name and / or reference numeral. Explanation is omitted.
  • the outer cylinder assembly 6 of this embodiment has a skin contact protrusion 91 at the tip thereof, and includes a skin contact member 90 detachably attached to the outer cylinder assembly 6.
  • the skin contact member 90 is detachably attached to the protective member 70.
  • the skin contact member 90 is formed separately from the outer cylinder 30 for a syringe with a needle and the protective member 70.
  • the material for forming the skin contact member 90 include polyolefins such as polyethylene and polypropylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly- (4-methylpentene-1), acrylic resin, and acrylonitrile-butadiene-styrene copolymer.
  • Polyester such as polyethylene terephthalate, cyclic polyolefin polymer, resin wire made of hard or semi-hard resin such as cyclic olefin copolymer, and elastic metal wire such as stainless steel are preferably used.
  • the skin contact member 90 preferably has flexibility. The seal cap can be easily removed.
  • the skin contact member 90 is detachably attached to the protective member 70 at the attachment portion 92.
  • the mounting portion 92 has a substantially cylindrical shape, and has a shape in which a part in the circumferential direction (a portion facing the portion to which the tip-side extending portion 93 to be described later is connected) is cut out (see FIG. 10). In FIG. 10, the seal cap 12 is not shown.)
  • the mounting portion 92 is elastically deformable (temporarily expanded in diameter) in the circumferential direction, and is detachably attached to the tip portion of the protective member 70.
  • the skin contact protrusion 91 of the skin contact member 90 is located in front of the puncture needle tip 35 and substantially on an extension line of the central axis of the injection needle 32.
  • the skin contact member 90 includes a tip-side extending portion 93 extending from the tip-side portion of the mounting portion 92 toward the tip end.
  • the distal end side extending portion 93 extends substantially on the extension line of the central axis of the injection needle 32 via the bent portion 94, and has a skin contact protrusion 91 at the tip thereof.
  • the skin contact protrusion 91 has a substantially quadrangular pyramid shape that protrudes so as to be convex toward the tip, and is considered to generate a predetermined irritation (pain) by contacting the patient's skin.
  • the tip end side extending portion 93 extends in a predetermined length up to the bent portion 94, and the tip end is parallel to the axial direction from the connecting portion with the mounting portion 92. It extends in the direction, whereby a space for removing the seal cap 12 is secured in the direction of the tip of the protective member 70.
  • the outer cylinder assembly 6 of this embodiment is formed at the base end portion of the skin contact member 90, and includes a stopper portion 95 that regulates the relative movement of the outer cylinder 30 for a syringe with a needle with respect to the protective member 70. ..
  • the skin contact member 90 includes a proximal end side extending portion 96 extending from the proximal end side portion of the mounting portion 92 toward the proximal end direction.
  • the base end side extending portion 96 has its base end portion (extending direction tip portion) entered into the inside of the protective member 70 (the first guide path 72 of the inner cylinder portion 71, which will be described later) via the bent portion.
  • the collar member 74 functions as a stopper portion 95 when it comes into contact with the first protrusion 75, which will be described later.
  • the collar member 74 of this embodiment is rotatably and non-movably attached around the needle fixing portion 34 of the outer cylinder 30 for a syringe with a needle (outer cylinder 31), and as shown in FIG.
  • a pair of first protrusions 75 and second protrusions 76 that project outward in the radial direction facing each other are formed on the large diameter portion 48.
  • the first protrusion 75 and the second protrusion 76 are arranged in the first guide path 72 and the second guide path 73 formed in the protective member 70 (inner cylinder portion 71) described later, respectively.
  • the protective member 70 of this embodiment includes an inner cylinder portion 71 and an outer cylinder portion 77.
  • the inner cylinder portion 71 and the outer cylinder portion 77 are fixed to each other so as not to move (rotate) relative to each other in the axial direction and the circumferential direction (rotation direction).
  • a first guide path 72 and a second guide path 73 having a predetermined shape are formed on the side wall portion 78 of the inner cylinder portion 71.
  • the first guide path 72 and the second guide path 73 are formed so as to penetrate the inner tubular portion 71 in the radial direction (thickness direction).
  • the first protrusion 75 and the second protrusion 76 of the collar member 74 are arranged in the first guide path 72 and the second guide path 73, respectively.
  • the first guide path 72 and the second guide path 73 guide the first protrusion 75 and the second protrusion 76 provided on the collar member 74 as the outer cylinder 30 for a syringe with a needle moves relative to the protective member 70. (Defines the rotational movement of the collar member 74).
  • the first guideway 72 and the second guideway 73 are formed in different shapes from each other, and their respective actions are different.
  • the movements of the first protrusion 75 and the second protrusion 76 in the first guideway 72 and the second guideway 73, and their functions will be briefly described.
  • the first protrusion 75 and the second protrusion 76 are sideways and opposite to the moving direction (rotation direction) with respect to the protective member 70 (FIGS. 12 and 13). Inside, it is formed in a substantially triangular shape with vertices on the right side).
  • the first protrusion 75 is the first guide path.
  • the second protrusion 76 is located at the initial position portion 80 of 72, and the second protrusion 76 is located at the initial position portion 81 of the second guideway 73.
  • the first protrusion 75 and the second protrusion 76 are shown by arrows X1 and X2 in FIGS. 12 and 13, respectively, as the outer cylinder 30 for a syringe with a needle moves toward the tip of the protective member 70.
  • the first guideway 72 and the second guideway 73 are moved toward the puncture positions 82 and 83 so as to be used.
  • the first protrusion 75 and the second protrusion 76 are guided mainly by the movement of the second protrusion 76 along the second guide path 73.
  • the position of the collar member 74 in the rotational direction is defined by the position of the second protrusion 76 guided by the second guide path 73.
  • the first guide path 72 is provided with a first elastic piece 86 between the initial position portion 80 and the puncture position portion 82.
  • the first protrusion 75 comes into contact with the first elastic piece 86 in the process of moving from the initial position portion 80 to the puncture position portion 82 in the first guide path 72, and after the first elastic piece is temporarily elastically deformed. , The contact between the first protrusion 75 and the first elastic piece 86 is released. As a result, the user can know the state of the drug solution administration tool 10 by clicking sound and touch.
  • the protective member 70 moves toward the tip by the urging force of the urging member 45.
  • the first protrusion 75 and the second protrusion 76 are shown by arrows Y1 and Y2 in FIGS. 12 and 13, respectively.
  • the first guide path 72 and the second guide path 73 move from the puncture position portions 82 and 83 toward the lock position portions 84 and 85.
  • the first protrusion 75 and the second protrusion 76 are mainly locked by the first protrusion 75 moving along the inclined surface 88 of the second elastic piece 87 provided on the first guide path 72. You will be guided to parts 84 and 85.
  • the first protrusion 75 came into contact with the second elastic piece 87 in the process of moving from the puncture position portion 82 to the lock position portion 84 in the first guide path 72, and temporarily elastically deformed the second elastic piece 87. After that, the contact between the first protrusion 75 and the second elastic piece 87 is released. As a result, the user can know the state of the drug solution administration tool 10 by clicking sound and touch.
  • the first protrusion 75 and the second protrusion 76 reach the lock position portions 84 and 85 and then try to move the outer cylinder 30 for a syringe with a needle toward the tip of the protective member 70, the first protrusion The 75 and the second protrusion 76 abut on the lock surfaces 101 and 102 formed on the first guide path 72 and the second guide path 73, respectively, which are exposed in the proximal direction, so that the outer cylinder 30 for the syringe with a needle can move. Be regulated. As a result, the exposure of the injection needle 32 after the puncture is more reliably prevented.
  • the stopper portion 95 formed at the base end portion of the skin contact member 90 is the initial position portion of the first guide path 72. It is arranged directly above the first protrusion 75 arranged at 80 (cross hatch portion in FIG. 12). Therefore, the movement of the first protrusion 75 arranged at the initial position portion 80 of the first guide path 72 is restricted by the stopper portion 95, and the collar member 74 on which the first protrusion 75 is formed cannot move in the axial direction.
  • the outer cylinder portion 77 of the protective member 70 is fixed to the inner cylinder portion 71 so as not to move (rotate) relative to the inner cylinder portion 71 in the axial direction and the circumferential direction (rotation direction).
  • the outer cylinder portion 77 has a substantially cylindrical shape having a diameter larger than that of the inner cylinder portion 71, and the inner cylinder portion is prevented so that the first guide path 72 and the second guide path 73 formed in the inner cylinder portion 71 are not exposed to the outside. It covers 71 from the outside.
  • a hole 79 through which the stopper portion 95 of the skin contact member 90 can enter is formed in the side wall portion of the outer tubular portion 77.
  • the seal cap 12 is removed from the drug solution administration tool 10 to which the skin contact member 90 is attached to the protective member 70. At this time, since a predetermined space is formed in the direction of the tip of the protective member 70 by the bent portion 94 formed in the extending portion 93 on the tip side of the skin contact member 90, the user can easily attach the seal cap 12. Can be removed.
  • the user searches for a low pain point site using the skin contact protrusion 91 formed at the tip of the skin contact member 90 (trial puncture).
  • tissue puncture it is preferable to hold the protective member 70 for trial puncture, but even when the outer cylinder 31 portion exposed from the base end of the protective member 70 is held for trial puncture, the skin contact member 90 is subjected to trial puncture.
  • the formed stopper portion 95 regulates the relative movement of the outer cylinder 30 for a syringe with a needle with respect to the protective member 70, the syringe with a needle unintentionally resists the urging force of the urging member 45.
  • the outer cylinder 30 moves toward the tip of the protective member 70, and the puncture needle tip 35 projects (exposed) from the tip of the protective member 70 (the tip opening of the tip annular wall 43 of the inner cylinder 71). Is prevented.
  • the skin contact protrusion 91 is located in front of the puncture needle tip 35 and substantially on the extension line of the central axis of the injection needle 32. Therefore, the desired puncture site can be searched for more accurately.
  • the skin contact member 90 attached to the protective member 70 is removed (disengaged). At this time, it is desirable not to move the outer cylinder 30 for a syringe with a needle in a direction orthogonal to the axial direction as much as possible.
  • the outer cylinder 30 for a syringe with a needle is moved toward the tip, and the injection needle 32 (puncture needle tip 35) is punctured at a desired puncture site (low pain point site determined by trial puncture).
  • the moving state (movement start or puncture completion) of the needle-attached syringe outer cylinder 30 can be grasped by the contact or release of the contact between the first protrusion 75 and the first elastic piece 86 described above.
  • the plunger 22 is operated to administer (inject) the medical liquid 11 into the body.
  • the drug solution administration tool 10 After administration of the medical liquid 11, the drug solution administration tool 10 is removed from the puncture site. At this time, the protective member 70 is moved toward the tip by the urging force of the urging member 45, and the injection needle 32 including the puncture needle tip 35 is not exposed to the outside again. Cover the tip side part. Therefore, the puncture needle tip 35 is prevented from being exposed to the outside after puncture, which is more hygienic.
  • the contact between the first protrusion 75 and the second protrusion 76 described above and the lock surfaces 101 and 102 can more reliably prevent the exposure of the injection needle 32 after puncture. Further, the moving state (activation of the lock mechanism) of the outer cylinder 30 for the syringe with a needle can be grasped by the contact or release of the contact between the first protrusion 75 and the second elastic piece 87 described above.
  • the skin contact member 90a may be attached to the outer cylinder 30 for a syringe with a needle, as in the outer cylinder assembly 6a (drug administration tool 10a, syringe 20a) shown in FIG.
  • the outer cylinder 30 for a syringe with a needle is relative to the protective member 70 without providing the stopper portion (extending portion on the base end side) described above. Movement can be regulated.
  • the bent portion 94a may be provided in the vicinity of the tip of the protective member 70 in the distal end side extending portion 93a.
  • the skin contact member 90a may be attached to the outer cylinder 30 for a syringe with a needle after removing the seal cap (not shown in FIG. 14) from the drug solution administration tool.
  • the fragile portion 103 is located near the connecting portion between the mounting portion 92b and the distal end extending portion 93b having the skin contact protrusion 91b.
  • the attachment portion 92b and the distal end side extension portion 93b may be separated from each other in the fragile portion 103 after the trial puncture and before the puncture.
  • the tip-side extending portion 93b having the skin contact protrusion 91b constitutes the skin contact member detachably attached to the protective member 70 in the outer cylinder assembly 6b.
  • a fragile portion 104 is provided in the vicinity of the connecting portion between the mounting portion 92b and the base end side extending portion 96b having the stopper portion (not shown in FIG. 15), and the fragile portion is provided after the trial puncture and before the puncture.
  • the attachment portion 92b and the proximal end side extension portion 96b may be separated to release the stopper mechanism.
  • the outer cylinder assembly of the present invention may be as follows.
  • the outer cylinder assembly of this embodiment has an outer cylinder 31 having a needle fixing portion 34 provided at the tip of the outer cylinder main body 33, and a puncture needle tip 35 at the tip, and has a needle of the outer cylinder 31.
  • An outer cylinder 30 for a syringe having a needle 32 having a base end fixed to a fixing portion 34, and a seal cap 12a attached to the outer cylinder so as to seal the puncture needle tip 35 of the injection needle 32. To be equipped.
  • the outer cylinder assembly includes a contact member that is located on the tip side of the puncture needle tip 35 of the injection needle 32 and has a skin contact protrusion that protrudes toward the tip.
  • the contact member can be detached from the outer cylinder 31, or the skin contact protrusion forming portion of the contact member can rotate in the direction of the proximal end or sideways of the outer cylinder 31.
  • the skin contact protrusions 91c and 91d of the skin contact members 90c and 90d are located in front of the puncture needle tip 35 and substantially on the extension line of the central axis of the injection needle 32. positioned.
  • the contact member 90c can be detached from the outer cylinder 31.
  • the skin contact member 90c is detachably attached to the outer surface of the tip end portion of the outer cylinder main body 33 of the outer cylinder 30 for a syringe with a needle by the attachment portion 92c.
  • the mounting portion 92c has a side opening, and an elastically deformable member having a C-shaped cross section is used.
  • An outer cylinder assembly (not provided with a contact member) can be inserted into the mounting portion 92c from the tip direction. Therefore, the outer cylinder assembly (not provided with the contact member) can be removed from the mounting portion 92c.
  • the skin contact protrusion forming portion 93d of the contact member 90d is rotatable toward the side of the outer cylinder 31.
  • the skin contact protrusion forming portion of the contact member may be rotatable in the direction of the base end of the outer cylinder 31.
  • the skin contact protrusion 91d of the skin contact member 90d is located in front of the puncture needle tip 35 and substantially on the extension line of the central axis of the injection needle 32.
  • the skin contact member 90d is attached to the outer surface of the tip end portion of the outer cylinder main body 33 of the outer cylinder 30 for a syringe with a needle by the attachment portion 92d.
  • the mounting portion 92d has a side opening, and an elastically deformable member having a C-shaped cross section is used.
  • An outer cylinder assembly (not provided with a contact member) can be inserted into the mounting portion 92d from the tip direction.
  • the skin contact protrusion forming portion 93d of the contact member 90d is provided with a spherical portion at the lower end.
  • the mounting portion 92d is provided with an entry slit on the side surface of the skin contacting protrusion forming portion 93d. Therefore, as shown in FIG. 17, the skin contact protrusion forming portion 93d is rotatable in the side surface direction with the spherical portion as an axis.
  • the skin contact protrusion forming portion 93d is rotated to the side of the outer cylinder 31, the seal cap 12a is removed, and then the skin contact protrusion forming portion 93d is formed. It was rotated again to return to the state shown in FIG. 17, the skin contact protrusion 91d was used to search for a low pain site, and the skin contact protrusion forming portion 93d was rotated sideways to the outer cylinder 31 again. Later, the puncture needle tip 35 can be punctured at the searched low pain site.
  • the chemical solution administration tool and the prefilled syringe can be produced by using the outer cylinder assemblies 6c and 6d described above.
  • the chemical administration tool is housed in the outer cylinder assembly 6c or 6d and the outer cylinder 30 for a syringe with a needle of the outer cylinder assembly, and slides in the outer cylinder 30 for a syringe with a needle in a liquid-tight state. It will be provided with a possible gasket and a plunger for pressing the gasket.
  • the prefilled syringe further includes a medical liquid filled in the outer cylinder 30 for a syringe with a needle. Also in this embodiment, the above-mentioned ones can be used as the outer cylinder, the injection needle, the gasket, the plunger, the seal cap, and the medical liquid.
  • the outer cylinder assembly of the present invention is as follows. (1) An outer cylinder having an outer cylinder main body, a needle fixing portion provided at the tip of the outer cylinder main body, and a puncture needle tip at the tip, and the needle fixing portion of the outer cylinder An outer cylinder assembly including an outer cylinder for a syringe with a needle having an injection needle having a fixed base end portion and a tubular protective member attached to the tip end portion of the outer cylinder for a syringe with a needle. The protective member wraps the tip side portion of the outer cylinder for a syringe with a needle including the puncture needle tip so as to be projectable, and the outer cylinder assembly is the puncture needle tip of the injection needle. An outer cylinder assembly having a protrusion for skin contact that is located closer to the tip and projects toward the tip.
  • the outer cylinder assembly of the present invention is attached to the tip of the outer cylinder for a syringe with a needle and the outer cylinder for a syringe with a needle so that the tip side portion including the needle tip for piercing the outer cylinder for a needle can be projected.
  • It is provided with a protective member to be wrapped, and further includes a skin contacting protrusion located on the tip side of the needle tip for puncturing the injection needle and protruding toward the tip. Therefore, when the puncture needle tip is covered with the protective member (the puncture needle tip is not exposed to the outside), the injection needle is not directly punctured by the skin contact protrusion, and the puncture is relatively painless. It is hygienic because you can search for a place (so-called "trial puncture").
  • the above-mentioned embodiment may be as follows. (2) The outer cylinder assembly according to (1) above, wherein the skin contact protrusion is formed at the tip of the protective member. (3) The outer cylinder assembly according to (1) or (2) above, wherein the protective member has a cylindrical shape, and a plurality of protrusions for contacting the skin are formed on the tip surface of the protective member in the circumferential direction. Three-dimensional. (4) The outer cylinder assembly according to (1) above, wherein the outer cylinder assembly has the skin contact protrusion at the tip and includes a skin contact member detachably attached to the outer cylinder assembly. Three-dimensional.
  • the outer cylinder assembly according to (4) above, wherein the skin contact member is detachably attached to the outer cylinder for a syringe with a needle or the protective member.
  • the skin contact protrusion of the skin contact member is located in front of the puncture needle tip and substantially on an extension line of the central axis of the injection needle (4) or (5).
  • the outer cylinder assembly is formed at the base end portion of the skin contact member, and includes a stopper portion that regulates the relative movement of the outer cylinder for a syringe with a needle with respect to the protective member.
  • the outer cylinder assembly according to any one of (6) to (6).
  • the outer cylinder assembly includes an urging member that urges the protective member toward the tip relative to the outer cylinder for a syringe with a needle (1) to (7).
  • the outer cylinder assembly of the present invention is as follows. (9) An outer cylinder having an outer cylinder main body and a needle fixing portion provided at the tip of the outer cylinder main body, and a puncture needle tip at the tip, the needle fixing portion of the outer cylinder An outer cylinder assembly comprising a needle-attached syringe outer cylinder having an injection needle with a fixed base end and a seal cap attached to the outer cylinder so as to seal the puncture needle tip of the injection needle.
  • the outer cylinder assembly includes a contact member that is located on the tip side of the injection needle with respect to the tip of the puncture needle and has a skin contact protrusion that protrudes toward the tip, and the contact member. Is an outer cylinder assembly that can be detached from the outer cylinder or that the skin contact protrusion on the contact member can rotate in the direction of the base end or side of the outer cylinder.
  • the syringe of the present invention is as follows. (10) The outer cylinder assembly according to any one of (1) to (9) above, and the outer cylinder for a syringe with a needle, which is housed in the outer cylinder for a syringe with a needle of the outer cylinder assembly, and inside the outer cylinder for a syringe with a needle.
  • a syringe consisting of a gasket that can slide in a liquid-tight state and a plunger for pressing the gasket.
  • the syringe of the present invention is attached to the tip of the outer cylinder for a syringe with a needle and the outer cylinder for a syringe with a needle, and encloses the tip side portion including the needle tip for puncture of the outer cylinder for a syringe with a needle so as to be prominent. It is provided with a protective member, and further includes a skin contacting protrusion that is located on the tip side of the needle tip for puncturing the injection needle and that protrudes toward the tip. Therefore, when the puncture needle tip is covered with the protective member (the puncture needle tip is not exposed to the outside), the injection needle is not directly punctured by the skin contact protrusion, and the puncture is relatively painless. It is hygienic because you can search for a place (so-called "trial puncture").
  • the drug solution administration tool of the present invention is as follows. (11) The outer cylinder assembly according to any one of (1) to (9) above, and the outer cylinder for a syringe with a needle, which is housed in the outer cylinder for a syringe with a needle of the outer cylinder assembly, and inside the outer cylinder for a syringe with a needle.
  • a chemical administration tool comprising a gasket slidable in a liquid-tight state, a plunger for pressing the gasket, and a medical liquid filled in the outer cylinder for a syringe with a needle.
  • the drug solution administration tool of the present invention is attached to the tip of the outer cylinder for a syringe with a needle and the outer cylinder for a syringe with a needle so that the tip side portion including the needle tip for puncture of the outer cylinder for a syringe with a needle can be projected.
  • It is provided with a protective member for wrapping, and further includes a protrusion for skin contact that is located on the tip side of the needle tip for puncturing the injection needle and protrudes toward the tip. Therefore, when the puncture needle tip is covered with the protective member (the puncture needle tip is not exposed to the outside), the injection needle is not directly punctured by the skin contact protrusion, and the puncture is relatively painless. It is hygienic because you can search for a place (so-called "trial puncture").

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Ensemble tube externe 3 pourvu d'un tube externe 30 avec une aiguille pour une seringue et d'un élément de protection 40 qui est monté sur l'extrémité distale du tube externe 30 avec une aiguille pour une seringue, et entourant une partie latérale d'extrémité distale du tube externe 30 avec une aiguille pour une seringue comprenant une pointe d'aiguille de ponction 35 de telle sorte que la partie latérale d'extrémité distale peut faire saillie. L'ensemble tube externe 3 est en outre pourvu d'une saillie de contact avec la peau 41 qui est positionnée de manière distale par rapport à la pointe d'aiguille de perforation 35 de l'aiguille d'injection 32 et fait saillie vers l'extrémité distale.
PCT/JP2021/003899 2020-03-25 2021-02-03 Ensemble tube externe, seringue et instrument d'administration de médicament liquide WO2021192638A1 (fr)

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JP2020054805 2020-03-25

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023272341A1 (fr) * 2021-06-30 2023-01-05 Prudenfort Pty Ltd Dispositif de distraction pour insertion d'aiguille dans un tissu

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020013602A1 (en) * 2000-07-31 2002-01-31 Huttner James J. Method for controlling the pain from injections or minor surgical procedures and apparatus for use therewith
WO2004021886A1 (fr) * 2002-09-05 2004-03-18 Matsushita Electric Industrial Co., Ltd. Appareil pour technique invasive
DE102004025651A1 (de) * 2004-05-26 2005-12-22 Tecpharma Licensing Ag Vorrichtung zum schmerzfreien Eindringen eines Stechmittels in ein Gewebe
US20120203137A1 (en) * 2011-02-03 2012-08-09 Avishai Neuman, Md, Pllc Reduced-pain needle assembly
JP2016537089A (ja) * 2013-11-14 2016-12-01 アレス トレーディング ソシエテ アノニム 疼痛低減部材を備える薬剤注入装置
JP2018502670A (ja) * 2015-01-26 2018-02-01 バイオコープ・プロダクション 針を保護するためのデバイス、かかるデバイスを備えるシリンジ、および事前充填されたセメント固定針シリンジを作製するための方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020013602A1 (en) * 2000-07-31 2002-01-31 Huttner James J. Method for controlling the pain from injections or minor surgical procedures and apparatus for use therewith
WO2004021886A1 (fr) * 2002-09-05 2004-03-18 Matsushita Electric Industrial Co., Ltd. Appareil pour technique invasive
DE102004025651A1 (de) * 2004-05-26 2005-12-22 Tecpharma Licensing Ag Vorrichtung zum schmerzfreien Eindringen eines Stechmittels in ein Gewebe
US20120203137A1 (en) * 2011-02-03 2012-08-09 Avishai Neuman, Md, Pllc Reduced-pain needle assembly
JP2016537089A (ja) * 2013-11-14 2016-12-01 アレス トレーディング ソシエテ アノニム 疼痛低減部材を備える薬剤注入装置
JP2018502670A (ja) * 2015-01-26 2018-02-01 バイオコープ・プロダクション 針を保護するためのデバイス、かかるデバイスを備えるシリンジ、および事前充填されたセメント固定針シリンジを作製するための方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023272341A1 (fr) * 2021-06-30 2023-01-05 Prudenfort Pty Ltd Dispositif de distraction pour insertion d'aiguille dans un tissu

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