WO2021100676A1 - Préparation externe pour la peau - Google Patents

Préparation externe pour la peau Download PDF

Info

Publication number
WO2021100676A1
WO2021100676A1 PCT/JP2020/042695 JP2020042695W WO2021100676A1 WO 2021100676 A1 WO2021100676 A1 WO 2021100676A1 JP 2020042695 W JP2020042695 W JP 2020042695W WO 2021100676 A1 WO2021100676 A1 WO 2021100676A1
Authority
WO
WIPO (PCT)
Prior art keywords
mass
less
skin
component
external preparation
Prior art date
Application number
PCT/JP2020/042695
Other languages
English (en)
Japanese (ja)
Inventor
典子 手島
真由美 武谷
Original Assignee
花王株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 花王株式会社 filed Critical 花王株式会社
Priority to CN202080079384.4A priority Critical patent/CN114727920A/zh
Priority to KR1020227015676A priority patent/KR20220080162A/ko
Publication of WO2021100676A1 publication Critical patent/WO2021100676A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0254—Platelets; Flakes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G23/00—Compounds of titanium
    • C01G23/04—Oxides; Hydroxides
    • C01G23/047—Titanium dioxide

Definitions

  • the present invention relates to an external preparation for skin.
  • Patent Document 1 International Publication No. 2009/017104 states that infrared rays prevent infrared rays from reaching deeper into the dermis and subcutaneous tissues than the tissues of the skin, and those by infrared rays.
  • Patent Document 2 Japanese Unexamined Patent Publication No. 2017-95361 discloses a near-infrared protective cosmetic composition composed of titanium oxide powder and zinc oxide powder, which has both excellent near-infrared protection effect and high transparency. Has been done.
  • the present invention relates to the following [1] and [2].
  • the compounding amount of the component (a) is 5% by mass or more and 70% by mass or less, and the compounding amount of the component (b) is 100% by mass with respect to the total compounding amount of the components (a) to (c) of 100% by mass.
  • An external preparation for skin having an amount of 15% by mass or more and 75% by mass or less and a blending amount of the component (c) of 5% by mass or more and 70% by mass or less.
  • component (a), component (b) and component (c) in 100 mass% of the total compounding amount of component (a)-(c) in the external preparation for skin.
  • the external preparation for skin of the present invention contains the following components (a) to (c): (A) Plate-like metal oxide with a thickness of 100 nm or more and 120 nm or less, (B) Plate-shaped metal oxides with a thickness of 125 nm or more and 145 nm or less, and (c) Plate-shaped metal oxides with a thickness of 180 nm or more and 200 nm or less.
  • the compounding amount of the component (a) is 5% by mass or more and 70% by mass or less, and the compounding amount of the component (b) is 100% by mass with respect to the total compounding amount of the components (a) to (c) of 100% by mass.
  • the external preparation for skin of the present invention has the above structure, it has an excellent infrared ray protection effect and can obtain a natural color that blends with the skin color when applied to the skin.
  • an external preparation for skin with further improved infrared protection function is desired rather than the disclosed techniques of Patent Documents 1 and 2.
  • the external preparations for skin as a skin cosmetic, if it exhibits redness or bluish color, it becomes an unnatural color when applied to the skin, so that it is also required to have a color that matches the color of the skin.
  • the present invention relates to an external preparation for skin that has an excellent infrared protection effect, is less likely to have redness or bluish color when applied to the skin, and can obtain a natural color that blends in with the skin color.
  • the present inventors have found that a skin external preparation containing a combination of plate-like metal oxides having a predetermined thickness range and different thicknesses in a predetermined ratio can solve the above-mentioned problems.
  • the external preparation for skin of the present invention has an excellent infrared protective effect, and when applied to the skin, redness and blueness are less likely to be recognized, and a natural color that blends in with the skin color can be obtained.
  • skin makeup It is useful as a fee.
  • the thickness of the plate-shaped metal oxide means the length of the shortest shaft of the plate-shaped metal oxide particles.
  • infrared rays mean electromagnetic waves having a wavelength of 780 nm to 1 mm.
  • the external preparation for skin of the present invention is particularly excellent in the near-infrared ray protection effect having a wavelength of 780 nm to 2500 nm.
  • the infrared protection rate with a wavelength of 1500 nm is used as an index as the infrared protection effect.
  • the dosage form of the external preparation for skin of the present invention is not particularly limited, but it is preferably liquid, gel-like, or cream-like from the viewpoint of ease of application to the skin.
  • the external preparation for skin may be in the form of an emulsified composition, and the emulsified composition may be either an oil-in-water emulsified composition or a water-in-oil emulsified composition.
  • the external skin preparation of the present invention is preferably a skin cosmetic such as a sunscreen cosmetic (skin water, cream, milky lotion, beauty essence, etc.), suntan, makeup base cosmetic, and the like.
  • the external preparation for skin of the present invention contains the following components (a) to (c): (A) Plate-like metal oxide with a thickness of 100 nm or more and 120 nm or less, (B) A plate-shaped metal oxide having a thickness of 125 nm or more and 145 nm or less, and (c) a plate-shaped metal oxide having a thickness of 180 nm or more and 200 nm or less are blended.
  • the external preparation for skin of the present invention has an excellent infrared protection effect, a high heat-shielding feeling can be obtained, and the skin becomes white. It is difficult to use, and when applied to the skin, it also has the effect of obtaining a natural color that blends in with the skin color. The reason for this is not clear, but it can be considered as follows.
  • the present inventors selectively increase the reflectance of light in the infrared region by the interference effect of light by using a plate-shaped metal oxide having a predetermined thickness as an infrared protective agent in an external preparation for skin.
  • a plate-shaped metal oxide having a predetermined thickness as an infrared protective agent in an external preparation for skin.
  • an external preparation for skin containing a plate-like metal oxide as an infrared protective agent may have an unnatural color that does not blend with the skin, such as redness and blueness being observed when applied to the skin. It was found that there is.
  • the present inventors have achieved a high infrared protection effect by blending the components (a) to (c), which are plate-shaped metal oxides having different thicknesses, in the predetermined ratios.
  • the components (a) to (c) exhibit red, blue, and green interference colors, respectively, due to the wavelength of the reflected light.
  • the skin It is probable that a natural shade that blends in with the skin color could be obtained when applied to.
  • the thickness of the components (a) to (c) from the viewpoint of obtaining an excellent infrared protection effect by the above-mentioned action mechanism, and from the viewpoint of obtaining a natural color without becoming white when the external preparation for skin is applied to the skin. Is preferably in the following range, respectively.
  • the thickness of the component (a) is 100 nm or more, preferably 105 nm or more, 120 nm or less, preferably 115 nm or less.
  • the component (a) having a thickness in the above range exhibits a reddish interference color due to the wavelength of the reflected light.
  • the thickness of the component (b) is 125 nm or more, preferably 130 nm or more, and 145 nm or less, preferably 140 nm or less.
  • the component (b) having a thickness in the above range exhibits a bluish interference color due to the wavelength of the reflected light.
  • the thickness of the component (c) is 180 nm or more, preferably 185 nm or more, and 200 nm or less, preferably 195 nm or less.
  • the component (c) having a thickness in the above range exhibits a greenish interference color due to the wavelength of the reflected light.
  • the thicknesses of the components (a) to (c) can all be determined from the observation image by the scanning electron microscope (SEM).
  • the plate-shaped metal oxides of the components (a) to (c) are observed by SEM under the condition of an observation magnification of 10,000 times, and the thickness of 50 particles in the observation image is measured. Therefore, it is obtained by calculating the average value of the thickness per number.
  • the thicknesses of the components (a) to (c) can be measured by the method described in Examples.
  • the average particle size of the components (a) to (c) is preferably 20 ⁇ m or less, more preferably 15 ⁇ m or less, still more preferably 12 ⁇ m or less, and further. It is preferably 10 ⁇ m or less.
  • the average particle size of the components (a) to (c) is determined from the viewpoint of obtaining an excellent infrared protection effect and from the viewpoint of obtaining a natural color tone without becoming white when an external preparation for skin is applied to the skin. It is preferably 1 ⁇ m or more, more preferably 2 ⁇ m or more, still more preferably 3 ⁇ m or more, still more preferably 5 ⁇ m or more.
  • the specific range of the average particle size of the components (a) to (c) is preferably 1 ⁇ m or more and 20 ⁇ m or less, more preferably 2 ⁇ m or more and 15 ⁇ m or less, still more preferably 2 ⁇ m or more and 12 ⁇ m or less, still more preferably 3 ⁇ m or more and 10 ⁇ m or less. Even more preferably, it is 5 ⁇ m or more and 10 ⁇ m or less.
  • the average particle size of the components (a) to (c) is a median diameter (D50) measured at a particle size reference volume using a laser diffraction / scattering type particle size distribution measuring device. It can be measured by the method described.
  • the aspect ratios of the components (a) to (c) are preferably 10 or more. It is preferably 20 or more, more preferably 30 or more, and even more preferably 35 or more. Further, from the viewpoint of obtaining an excellent infrared protection effect and from the viewpoint of preventing whitening and reducing glare when the external preparation for skin is applied to the skin, it is preferably 200 or less, more preferably 150 or less, still more preferably. It is 100 or less, more preferably 90 or less.
  • the specific range of the aspect ratios of the components (a) to (c) is preferably 10 or more and 200 or less, more preferably 10 or more and 150 or less, still more preferably 10 or more and 100 or less, still more preferably 20 or more and 100 or less, and more. It is more preferably 30 or more and 100 or less, and even more preferably 35 or more and 90 or less.
  • the aspect ratios of the components (a) to (c) can be calculated from (average particle size / thickness).
  • the degree of glare when the external preparation for skin is applied to the skin is evaluated by measuring the gloss value at an angle of 60 ° using a gloss value measuring device for the coating film obtained by applying the external preparation for skin. Can be done.
  • metal oxides constituting the components (a) to (c) a material having a high refractive index can obtain a higher optical interference effect.
  • preferable metal oxides constituting the components (a) to (c) include titanium oxide, zinc oxide, zirconium oxide, iron oxide, aluminum oxide, cerium oxide and the like. Among these, one or more selected from the group consisting of titanium oxide and zinc oxide is preferable, and titanium oxide is more preferable. That is, the components (a) to (c) are preferably one or more selected from the group consisting of plate-shaped titanium oxide and plate-shaped zinc oxide, and more preferably plate-shaped titanium oxide.
  • the crystal structure of titanium oxide may be rutile type, anatase type, or amorphous, but the rutile type is preferable from the viewpoint of obtaining an excellent infrared protection effect and a feeling of heat shielding.
  • the plate-shaped metal oxides of the components (a) to (c) may not be surface-treated, and may be treated with a hydrophobic treatment by a known method, if necessary, in order to enhance the dispersibility in the external preparation for skin. It may be the one which has been subjected to the surface treatment of.
  • the plate-shaped metal oxides of the components (a) to (c) are distinguished from those in which the surface of particles other than the metal oxide is surface-treated with the metal oxide.
  • Examples of the surface treatment agent used for the surface treatment of the plate-shaped metal oxides according to the components (a) to (c) include silicone; alkylalkoxysilane; fluorine-containing compounds such as perfluoroalkyl phosphate and perfluoroalcohol; N. -Amino acids such as acylglutamic acid; other examples include lecithin; metal soap; fatty acids such as stearic acid; alkyl phosphates and the like.
  • one or more selected from the group consisting of silicone and alkylalkoxysilane is preferable from the viewpoint of enhancing the dispersibility of the components (a) to (c) in the external preparation.
  • Silicone as a surface treatment agent is not particularly limited, and for example, methylpolysiloxane, dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, etc.
  • Siloxane oil can be mentioned.
  • the alkylalkoxysilane as the surface treatment agent those having a branched or linear alkyl group having 6 to 20 carbon atoms are preferable, and examples thereof include octyltriethoxysilane and octyltrimethoxysilane.
  • the surface treatment agent is selected from the group consisting of methylpolysiloxane, dimethylpolysiloxane, methylhydrogenpolysiloxane, (alkyl acrylate / dimethicone) copolymer, and octylriethoxysilane1. More than a seed is preferred.
  • the blending amount of the component (a) is 5% by mass or more and 70% by mass or less with respect to 100% by mass of the total blending amount of the components (a) to (c), and the blending amount of the component (b). Is 15% by mass or more and 75% by mass or less, and the blending amount of the component (c) is 5% by mass or more and 70% by mass or less.
  • the blending amount of each component with respect to the total blending amount of the components (a) to (c) is within the above range, an excellent infrared ray protection effect and a natural color when the external preparation for skin is applied to the skin can be obtained. It is compatible.
  • the skin external preparation of the present invention has a total blending amount of 100% by mass of the components (a) to (c) from the viewpoint of achieving both an excellent infrared protection effect and a natural color when the skin external preparation is applied to the skin. It is preferable that the blending ratio of the component (a), the component (b) and the component (c) with respect to the above condition 1 satisfies the following condition 1, and more preferably the following condition 2 is satisfied.
  • Condition 1 In a three-phase diagram showing the mass% of the component (a), the component (b) and the component (c) with respect to 100% by mass of the total blending amount of the components (a) to (c), the blending ratio of each component is , It is within the range of the composition region surrounded by the 6 composition points shown below.
  • (A, b, c) (70,15,15), (28,26,46), (5,40,55), (5,67,28), (20,68,12), (57 , 33, 10)
  • Condition 2 In a three-phase diagram showing the mass% of the component (a), the component (b) and the component (c) with respect to 100% by mass of the total blending amount of the components (a) to (c), the blending ratio of each component is , It is within the range of the composition region surrounded by the 6 composition points shown below.
  • (A, b, c) (50,28,22), (25,45,30), (25,32,43), (15,43,42), (23,55,22), (42) , 43, 15)
  • FIG. 1 is a three-phase diagram showing the mass% of the component (a), the component (b) and the component (c) in the total blending amount of the components (a) to (c) in the external preparation for skin of 100% by mass. ..
  • the blending amount of the component (a) in the region 1 surrounded by the thick solid line, is 5% by mass or more and 70% by mass or less with respect to the total blending amount of 100% by mass of the components (a) to (c).
  • the composition region in which the blending amount of the component (b) is 15% by mass or more and 75% by mass or less and the blending amount of the component (c) is 5% by mass or more and 70% by mass or less is shown.
  • the region 2 surrounded by the broken line in the three-phase diagram of FIG. 1 is a composition region satisfying the above condition 1.
  • (a, b, c) (70,15,15), (28,26,46), (5,40,55), (5,67,28), (20,68,12). ) And (57, 33, 10) are indicated by " ⁇ ".
  • the region 3 surrounded by the alternate long and short dash line in the three-phase diagram of FIG. 1 is a composition region that satisfies the above condition 2.
  • (a, b, c) (50,28,22), (25,45,30), (25,32,43), (15,43,42), (23,55,22). ) And (42, 43, 15) are indicated by “ ⁇ ”.
  • the total amount of the components (a) to (c) in the external preparation for skin of the present invention is preferably 1% by mass or more, more preferably 1.5% by mass or more, still more preferably, from the viewpoint of obtaining an excellent infrared protection effect. Is 2% by mass or more. Further, from the viewpoint of obtaining a natural color that does not easily turn white when the external preparation for skin is applied to the skin and from the viewpoint of economy, it is preferably 35% by mass or less, more preferably 25% by mass or less, still more preferably 20. It is mass% or less, more preferably 15 mass% or less, still more preferably 10 mass% or less.
  • the specific range of the total blending amount of the components (a) to (c) in the external preparation for skin of the present invention is preferably 1% by mass or more and 35% by mass or less, more preferably 1% by mass or more and 25% by mass or less, still more preferably. Is 1% by mass or more and 20% by mass or less, more preferably 1% by mass or more and 15% by mass or less, further preferably 1.5% by mass or more and 10% by mass or less, still more preferably 2% by mass or more and 10% by mass or less. Is.
  • the external preparation for skin of the present invention does not exclude the addition of plate-shaped metal oxides other than the components (a) to (c), but the amount thereof is small from the viewpoint of obtaining the effects of the present invention. Is preferable.
  • the ratio of the components (a) to (c) in the total amount of the plate-shaped metal oxide blended in the external preparation for skin is preferably 70% by mass or more, more preferably 80% by mass or more, still more preferably. Is 90% by mass or more, more preferably 95% by mass or more, and 100% by mass or less.
  • plate-shaped metal oxides can also be used as the components (a) to (c).
  • CQV's "Featheleve PT-9001K", “Featheleve PT-7001K”, “Featheleve PT-7401K”, “Featheleve PT-7801K”, “Featheleve PT-7901K” and the like can be mentioned. .. It is more preferable to use these plate-shaped titanium oxides that have undergone the surface treatment as the components (a) to (c).
  • the pulverization treatment method is not particularly limited, and a known method can be used.
  • the pulverization treatment may be performed at any stage before the surface treatment and after the surface treatment.
  • the external preparation for skin of the present invention further contains a feel-improving agent as a component (d) from the viewpoint of suppressing stickiness when applied to the skin and obtaining a smooth and good feel when an oil agent or the like described later is blended. It is preferable to do so.
  • the feel improving agent may be any of organic particles, inorganic particles other than the above-mentioned components (a) to (c), and a mixture thereof, and those usually blended in cosmetics can be used. From the viewpoint of obtaining a good feel when applied to the skin, the shape of the particles is preferably spherical. Further, those having irregularities on the particle surface or those having a porous surface may be used.
  • organic particles used as the component (d) include acrylic resin, silicone resin, polystyrene resin, polyamide resin, polyester resin, polyolefin resin, polystyrene resin, polyurethane resin, vinyl resin, urea resin, phenol resin, and fluororesin.
  • resin particles composed of resins such as melamine resin, epoxy resin, polycarbonate resin, acrylic-silicone copolymer resin, acrylic-styrene copolymer resin, and cellulose. These resin particles may be crosslinked resin particles or non-crosslinked resin particles.
  • Metal oxide particles are preferable as the inorganic particles other than the components (a) to (c), and examples of the metal oxide include titanium oxide, zinc oxide, zirconium oxide, iron oxide, aluminum oxide, and cerium oxide. Be done. Among these, one or more selected from the group consisting of titanium oxide and zinc oxide is preferable, and titanium oxide is more preferable.
  • the component (d) is preferably a spherical inorganic particle, more preferably a spherical metal oxide particle, and further preferably one selected from the group consisting of spherical titanium oxide particles and spherical zinc oxide particles. These are the above, and even more preferably, spherical titanium oxide particles.
  • the average particle size of the particles used as the component (d) is preferably 0.1 ⁇ m or more, more preferably 0.2 ⁇ m or more, still more preferably 0.2 ⁇ m or more, from the viewpoint of suppressing stickiness when applied to the skin and obtaining a good feel. Is 0.5 ⁇ m or more. Further, from the viewpoint of suppressing stickiness when applied to the skin to obtain a good feel, and from the viewpoint of preventing whitening when the external preparation for skin is applied to the skin, it is preferably 10 ⁇ m or less, more preferably 5 ⁇ m or less, and further. It is preferably 2 ⁇ m or less.
  • the specific range of the average particle size of the particles used as the component (d) is preferably 0.1 ⁇ m or more and 10 ⁇ m or less, more preferably 0.2 ⁇ m or more and 5 ⁇ m or less, and further preferably 0.5 ⁇ m or more and 2 ⁇ m or less.
  • the average particle size can be measured by the same method as described above.
  • the component (d) When the component (d) is used in the external preparation for skin of the present invention, its content is preferably 1% by mass or more in the external preparation for skin from the viewpoint of suppressing stickiness when applied to the skin and obtaining a good feel. , More preferably 1.5% by mass or more, still more preferably 2% by mass or more. Further, from the viewpoint of suppressing stickiness when applied to the skin to obtain a good feel, and from the viewpoint of preventing whitening when the external preparation for skin is applied to the skin, it is preferably 20% by mass or less, more preferably 15% by mass. % Or less, more preferably 10% by mass or less.
  • the specific range of the content of the component (d) in the external preparation for skin of the present invention is preferably 1% by mass or more and 20% by mass or less, more preferably 1% by mass or more and 15% by mass or less, and further preferably 1% by mass or more. It is 10% by mass or less, more preferably 1.5% by mass or more and 10% by mass or less, and even more preferably 2% by mass or more and 10% by mass or less.
  • the mass ratio [ ⁇ (a) + (b) + (c) ⁇ / (d)] of the total amount of the components (a) to (c) and the component (d) is determined.
  • it is preferably 0.1 or more, more preferably 0.2 or more, and further. It is preferably 0.5 or more.
  • it is preferably 5 or less, more preferably 3 or less, still more preferably 2 or less, still more preferably 1.5 or less.
  • the specific range of the mass ratio [ ⁇ (a) + (b) + (c) ⁇ / (d)] is preferably 0.1 or more and 5 or less, more preferably 0.2 or more and 3 or less, and further preferably 0. It is .5 or more and 2 or less, more preferably 0.5 or more and 1.5 or less.
  • the external preparation for skin of the present invention preferably further contains an ultraviolet absorber as a component (e) from the viewpoint of imparting an ultraviolet protection effect in addition to the infrared protection effect.
  • an organic ultraviolet absorber is preferable, and an oil-soluble organic ultraviolet absorber or a water-soluble organic ultraviolet absorber can be used.
  • the component (e) is preferably an oil-soluble organic UV absorber from the viewpoints of UV protection effect, natural appearance when applied to the skin, good cosmetic adhesion after application, and suppression of stickiness. ..
  • oil-soluble means that it is water-insoluble, and specifically means that the solubility in water is 1 w / w% or less.
  • the component (e) is distinguished from an inorganic ultraviolet absorber such as an ultraviolet absorber in which the surface of an inorganic filler is coated with an ultraviolet absorbing material.
  • an oil-soluble one among salicylic acid-based UV absorbers, cinnamic acid-based UV absorbers, benzoylmethane-based UV absorbers, and other organic UV absorbers can be used.
  • salicylic acid-based UV absorbers such as homomentyl salicylate and octyl salicylate; 2-Ethylhexyl paramethoxycinnamate (for example, "Ubinal MC80" manufactured by BASF), glyceryl diparamethoxycinnamate mono-2-ethylhexanate, methyl 2,5-diisopropylsilicate, methylbis trimethoxycinnamate (Trimethylsiloxy) Cinnamic acid-based ultraviolet absorbers such as silylisopentyl and isopropyl-diisopropylsilicate ester mixture of paramethoxycinnamate; Benzoylmethane-based UV absorbers such as 4-is
  • salicylic acid-based UV absorber As a water-soluble organic UV absorber, salicylic acid-based UV absorber, silicic acid-based UV absorber, benzoylmethane-based UV absorber, and other organic UV absorbers have a solubility in water of 1 w / w%. Those exceeding the above can be used, and examples thereof include salicylic acid triethanolamine salt, p-methoxyhydrosilicate diethanolamine salt and the like.
  • the component (e) includes 2-ethylhexyl paramethoxysilicate, 4-tert-butyl-4'-methoxydibenzoylmethane, octocrylene, and dimethoxybenzylidene dioxoimidazolidine propionic acid.
  • 2-Ethylhexyl, diethylaminohydroxybenzoyl hexyl benzoate, bisethylhexyloxyphenol methoxyphenyltriazine, methylenebisbenzotriazolyltetramethylbutylphenol, and 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino ] -1,3,5-Triazine is preferably one or more selected from the group consisting of 2-ethylhexyl paramethoxysilicate, hexyl diethylaminohydroxybenzoylbenzoate, bisethylhexyloxyphenol methoxyphenyltriazine, and 2,4.
  • one or more selected from the group consisting of 6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine More preferably, it is one or more selected from the group consisting of 2-ethylhexyl paramethoxycinnamate, hexyl diethylaminohydroxybenzoylbenzoate, and bisethylhexyloxyphenol methoxyphenyl triazine.
  • the content thereof is preferably 0.2% by mass or more, more preferably 1% by mass in the external preparation for skin from the viewpoint of imparting an excellent ultraviolet protection effect. % Or more, more preferably 3% by mass or more, still more preferably 5% by mass or more. Further, from the viewpoint of obtaining an excellent infrared protection effect and from the viewpoint of obtaining a natural color tone that is less likely to turn white when an external preparation for skin is applied to the skin, it is preferably 30% by mass or less, more preferably 25% by mass or less. , More preferably 20% by mass or less, and even more preferably 15% by mass or less.
  • the specific range of the content of the component (e) in the external preparation for skin is preferably 0.2% by mass or more and 30% by mass or less, more preferably 1% by mass or more and 25% by mass or less, and further preferably 3% by mass or more. It is 20% by mass or less, more preferably 5% by mass or more and 15% by mass or less.
  • the mass ratio [ ⁇ (a) + (b) + (c) ⁇ / (e)] of the total amount of the components (a) to (c) and the component (e) is determined.
  • it is preferably 0.1 or more, more preferably 0.2 or more, and further. It is preferably 0.3 or more.
  • it is preferably 5 or less, more preferably 3 or less, still more preferably 1 or less, still more preferably 0.5 or less.
  • the specific range of the mass ratio [ ⁇ (a) + (b) + (c) ⁇ / (e)] is preferably 0.1 or more and 5 or less, more preferably 0.1 or more and 3 or less, and further preferably 0. .2 or more and 1 or less, more preferably 0.3 or more and 1 or less, still more preferably 0.3 or more and 0.5 or less.
  • the external preparation for skin of the present invention has a viewpoint of improving the applicability to the skin by dispersing the components (a) to (c) and dispersing or dissolving other compounding components, as well as the oil-in-water type or water in oil. From the viewpoint of preparing a type of external preparation for skin, it is preferable to further contain an oil agent as the component (f).
  • an oil agent either a non-volatile oil (f1) or a volatile oil (f2) other than the component (e) can be used, and these can also be used in combination.
  • the oil agent (f) preferably contains at least a non-volatile oil (f1) from the viewpoint of dissolving the oil-soluble ultraviolet absorber.
  • Non-volatile oil (f1) The external preparation for skin of the present invention preferably contains a non-volatile oil (f1) as the oil (f).
  • the non-volatile oil means an oil having an evaporation amount of less than 20% at 25 ° C. for 6 hours, which is measured by the following method (1).
  • Method (1) A filter paper having a diameter of 90 mm is placed in a glass petri dish having a diameter of 120 mm, 1 g of a sample is placed on the filter paper, and the sample is stored in a room (25 ° C.) at 65% RH. Then, the residue of the sample after 6 hours is measured, and the amount of evaporation is calculated.
  • the component (f1) is preferably liquid at 25 ° C. under 1 atm. More specifically, the component (f1) has a viscosity at 25 ° C. of preferably 500 mPa ⁇ s or less, more preferably 300 mPa ⁇ s or less, still more preferably 100 mPa ⁇ s or less, and even more preferably. It is 50 mPa ⁇ s or less, preferably 5 mPa ⁇ s or more.
  • the viscosity was determined by using a B-type viscometer "TVB-10" (manufactured by Toki Sangyo Co., Ltd.). It can be measured under the conditions of 1, 25 ° C., 60 rpm and 1 minute.
  • component (f1) examples include non-volatile oils other than the component (e) that are liquid at 25 ° C., ester oils, silicone oils, hydrocarbon oils, higher fatty acids, and higher alcohols.
  • non-volatile liquid ester oil examples include isononyl isononanoate, isotridecyl isononanoate, isopropyl myristate, isocetyl myristate, octyldodecyl myristate, isopropyl palmitate, ethylhexyl palmitate, 2-hexyldecyl palmitate, and tri2.
  • pentylglycol and alkyl benzoate such as alkyl benzoate (C12 to C15) can be mentioned.
  • a monoester of a fatty acid having 12 or more and 18 or less carbon atoms and a branched alcohol having 2 or more and 22 or less carbon atoms, and 6 carbon atoms from the viewpoint of obtaining a natural color when applied to the skin and suppressing stickiness, a monoester of a fatty acid having 12 or more and 18 or less carbon atoms and a branched alcohol having 2 or more and 22 or less carbon atoms, and 6 carbon atoms.
  • Diesters with the following branched dialcohols, alkyl benzoates (C12 to C15) (for example, Finsolve TN; manufactured by Innospec Active Chemicals LLC) and the like are preferable, and specifically, isopropyl myristate, isosetyl myristate, octyldodecyl myristate, etc.
  • One or more selected from the group consisting of neopentyl glycol dicaprate and alkyl benzoate (C12 to C15) is more preferable, and one or more selected from the group consisting of isopropyl palmitate and alkyl benzoate (C12 to C15) is more preferable. More preferred.
  • methylpolysiloxane is preferable from the viewpoint of suppressing stickiness when applied to the skin, and methylpolysiloxane having a viscosity at 25 ° C. of 20 mPa ⁇ s or less is more preferable.
  • non-volatile liquid hydrocarbon oils examples include liquid paraffin, light liquid isoparaffin such as hydrogenated polyisobutene, heavy liquid isoparaffin, liquid zokerite, squalane, pristane, squalene, and isohexadecane.
  • light liquid isoparaffin such as hydrogenated polyisobutene
  • heavy liquid isoparaffin such as hydrogenated polyisobutene
  • liquid zokerite such as hydrogenated polyisobutene
  • squalane such as a heavy liquid isoparaffin
  • pristane such as pristane
  • squalene such as pristane
  • isohexadecane examples include liquid paraffin, light liquid isoparaffin such as hydrogenated polyisobutene, heavy liquid isoparaffin, liquid zokerite, squalane, pristane, squalene, and isohexadecane.
  • non-volatile liquid higher fatty acid examples include fatty acids having 12 or more and 22 or less carbon atoms, and specific examples thereof include oleic acid, isostearic acid, linoleic acid, and linoleic acid.
  • non-volatile liquid higher alcohol examples include alcohols having 12 to 28 carbon atoms, and specific examples thereof include oleyl alcohol, 2-decyltetradecinol, dodecanol, isostearyl alcohol, and octyldodecanol. Can be mentioned.
  • the component (f1) is one or more selected from the group consisting of ester oils, silicone oils and hydrocarbon oils, preferably from the viewpoint of suppressing stickiness when applied to the skin, among non-volatile oils that are liquid at 25 ° C. It is more preferably one or more selected from the group consisting of ester oils and hydrocarbon oils, and even more preferably selected from the group consisting of alkyl benzoate (C12-15), isopropyl palmitate, and light liquid isoparaffin. It is one or more kinds.
  • the external preparation for skin of the present invention contains the component (f1), the content thereof disperses the components (a) to (c) and disperses or dissolves other compounding components to improve the applicability to the skin.
  • the content thereof disperses the components (a) to (c) and disperses or dissolves other compounding components to improve the applicability to the skin.
  • it is preferably 1% by mass or more, more preferably 4% by mass or more, and further preferably 8% by mass or more.
  • it is preferably 99% by mass or less, more preferably 90% by mass or less, still more preferably 80% by mass or less, still more preferably.
  • the specific range of the content of the component (f1) in the external preparation for skin is preferably 1% by mass or more and 99% by mass or less, more preferably 4% by mass or more and 90% by mass or less, and further preferably 8% by mass or more and 80% by mass. % Or less, more preferably 8% by mass or more and 50% by mass or less, still more preferably 8% by mass or more and 30% by mass or less.
  • the mass ratio of the total amount of the components (a) to (c) to the component (f1) [ ⁇ (a) + (b) + (c) ⁇ / (F1)] is preferably 0.01 or more, from the viewpoint of obtaining an excellent ultraviolet protection effect, and from the viewpoint of obtaining a natural color tone without becoming white when an external preparation for skin is applied to the skin. It is preferably 0.05 or more, more preferably 0.1 or more, and prepares an oil-in-water type or a water-in-oil type skin external preparation from the viewpoint of dissolving an oil-soluble ultraviolet absorber, improving coatability, and preparing.
  • the specific range of the mass ratio [ ⁇ (a) + (b) + (c) ⁇ / (f1)] is preferably 0.01 or more and 10 or less, more preferably 0.01 or more and 5 or less, and further preferably 0. It is 0.05 or more and 3 or less, more preferably 0.1 or more and 1 or less, and even more preferably 0.3 or more and 0.5 or less.
  • the mass ratio [(e) / (f1)] is preferably 0.01 from the viewpoint of obtaining an excellent ultraviolet protection effect.
  • the above is more preferably 0.02 or more, further preferably 0.05 or more, still more preferably 0.1 or more, and when an oil-soluble ultraviolet absorber is used as the component (e), its dissolution. From the viewpoint of sex, it is preferably 10 or less, more preferably 5 or less, still more preferably 3 or less.
  • the specific range of the mass ratio [(e) / (f1)] is preferably 0.01 or more and 10 or less, more preferably 0.02 or more and 5 or less, still more preferably 0.05 or more and 3 or less, still more preferably. It is 0.1 or more and 3 or less.
  • the volatile oil is an oil agent other than the above-mentioned ultraviolet absorber (e), and the amount of evaporation at 25 ° C. for 6 hours measured by the following method (1) is 20% or more.
  • Method (1) A filter paper having a diameter of 90 mm is placed in a glass petri dish having a diameter of 120 mm, 1 g of a sample is placed on the filter paper, and the sample is stored in a room (25 ° C.) at 65% RH. Then, the residue of the sample after 6 hours is measured, and the amount of evaporation is calculated.
  • the component (f2) is preferably a volatile silicone oil, and more preferably a linear organopolysiloxane or a cyclic organopolysiloxane that is liquid and volatile at 25 ° C.
  • linear organopolysiloxane include octamethyltrisiloxane, decamethyltetrasiloxane, dodecamethylpentasiloxane, 1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl) oxy. ] -Trisiloxane can be mentioned.
  • cyclic organopolysiloxane examples include 4- to 6-membered cyclic siloxanes having an alkyl group having 1 or more and 5 or less carbon atoms as a substituent, and specific examples thereof include octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane. Can be mentioned.
  • cyclic organopolysiloxane is preferable, and decamethylcyclopentasiloxane is more preferable, from the viewpoint of suppressing stickiness when applied to the skin.
  • volatile silicone oils that can be used as component (f2) include “KF-96A-1cs” (octamethyltrisiloxane) and “KF-96L-1.5cs” manufactured by Shin-Etsu Chemical Industry Co., Ltd.
  • the content thereof can be appropriately selected depending on the dosage form of the external preparation for skin, but is preferably 1% by mass or more, more preferably 5% by mass or more. , More preferably, it can be 10% by mass or more. Further, from the viewpoint of suppressing stickiness when applied to the skin, it can be preferably 85% by mass or less, more preferably 80% by mass or less, and further preferably 75% by mass or less.
  • the specific range of the content of the component (f2) in the external preparation for skin is preferably 1% by mass or more and 85% by mass or less, more preferably 5% by mass or more and 80% by mass or less, and further preferably 10% by mass or more and 75% by mass. % Or less.
  • the external preparation for skin of the present invention is necessary from the viewpoint of dispersing or dissolving the components (a) to (c) and other compounding components, and from the viewpoint of preparing an oil-in-water type or a water-in-oil type skin external preparation.
  • an aqueous medium can be further contained.
  • the aqueous medium is not particularly limited as long as it can disperse or dissolve the components (a) to (c) and other compounding components, and is, for example, water; ethanol, isopropyl alcohol, butyl alcohol and the like having 4 carbon atoms.
  • the following monohydric alcohols low molecular weight diols having 6 or less carbon atoms such as 1,3-butylene glycol, glycerin, ethylene glycol, propylene glycol, diethylene glycol, and dipropylene glycol, and triol can be mentioned.
  • monohydric alcohols low molecular weight diols having 6 or less carbon atoms
  • one or more selected from the group consisting of water and a monohydric alcohol having 4 or less carbon atoms is preferable, and one or more selected from the group consisting of water and ethanol is more preferable.
  • the content thereof can be appropriately selected depending on the dosage form of the external preparation for skin, but is preferably 5% by mass or more, more preferably 8% by mass or more, still more preferably. It can be 10% by mass or more. Further, it can be preferably 99% by mass or less, more preferably 90% by mass or less, still more preferably 70% by mass or less, still more preferably 50% by mass or less.
  • the external preparation for skin of the present invention contains other components as required, such as surfactants, ultraviolet scattering agents, antiperspirants, fragrances, moisturizers, thickeners, bactericides, and pH adjusters. , Antioxidants, preservatives and the like can also be contained.
  • the method for producing the external preparation for skin of the present invention is not particularly limited, and a known method can be appropriately used depending on the dosage form of the external preparation for skin.
  • a method of blending the components (a) to (c) and all other components and uniformly mixing them with a homogenizer, a disper, or the like can be mentioned.
  • blending an aqueous medium it is also possible to use a method in which all the components other than the aqueous medium are blended, uniformly mixed with a disper or the like, then the aqueous medium is blended and further stirred and mixed with a homogenizer or the like.
  • the present invention also provides a method for protecting against infrared rays of the skin by applying the external preparation for skin of the present invention to the skin.
  • the protective method of the present invention is not particularly limited as long as it has a step of applying the external preparation for skin of the present invention to the skin.
  • the infrared protection rate at a wavelength of 1500 nm is preferably 10% or more, more preferably 12% or more, still more preferably 15% or more.
  • the infrared protection rate (%) is a value represented by 100-X (%) when the infrared transmittance measured by a spectrophotometer is X (%), and specifically, the method described in Examples. Can be measured by.
  • the present invention further discloses the following embodiments.
  • the blending amount of the component (a) is 5% by mass or more and 70% by mass or less, and the blending amount of the component (b) is 15% by mass or more and 75% by mass with respect to the total blending amount of the components (a) to (c) of 100% by mass. % Or less, and the blending amount of the component (c) is 5% by mass or more and 70% by mass or less, which is an external preparation for skin.
  • the plate-like metal oxide is preferably one or more selected from the group consisting of silicone and alkylalkoxysilane, more preferably methylpolysiloxane, dimethylpolysiloxane, methylhydrogenpolysiloxane, (alkyl acrylate / dimethicone) copolymer.
  • the thickness of the component (a) is preferably 105 nm or more and 115 nm or less, the thickness of the component (b) is preferably 130 nm or more and 140 nm or less, and the thickness of the component (c) is preferably 185 nm.
  • the external preparation for skin according to any one of ⁇ 1> to ⁇ 3>, which is 195 nm or less.
  • the average particle size of the components (a) to (c) is preferably 1 ⁇ m or more and 20 ⁇ m or less, more preferably 2 ⁇ m or more and 15 ⁇ m or less, still more preferably 2 ⁇ m or more and 12 ⁇ m or less, still more preferably 3 ⁇ m or more and 10 ⁇ m or less, still more preferably.
  • the aspect ratios of the components (a) to (c) are preferably 10 or more and 200 or less, more preferably 10 or more and 150 or less, still more preferably 10 or more and 100 or less, still more preferably 20 or more and 100 or less, still more preferably 30.
  • the external preparation for skin according to any one of ⁇ 1> to ⁇ 5>, which is 100 or more, more preferably 35 or more and 90 or less.
  • the compounding ratio of the component (a), the component (b) and the component (c) with respect to 100% by mass of the total compounding amount of the components (a) to (c) satisfies the following condition 1, and preferably the following condition 2 is further satisfied.
  • Condition 1 In a three-phase diagram showing the mass% of the component (a), the component (b) and the component (c) with respect to 100% by mass of the total blending amount of the components (a) to (c), the blending ratio of each component is , It is within the range of the composition region surrounded by the 6 composition points shown below.
  • the total amount of the components (a) to (c) in the external preparation for skin is preferably 1% by mass or more and 35% by mass or less, more preferably 1% by mass or more and 25% by mass or less, and further preferably 1% by mass or more and 20% by mass.
  • % Or less more preferably 1% by mass or more and 15% by mass or less, still more preferably 1.5% by mass or more and 10% by mass or less, still more preferably 2% by mass or more and 10% by mass or less, ⁇ 1> to An external preparation for skin according to any one of ⁇ 7>.
  • the external preparation for skin according to any one of ⁇ 1> to ⁇ 8>, which further contains a feel-improving agent as the component (d).
  • the component (d) is preferably spherical inorganic particles, more preferably spherical metal oxide particles, and further preferably one or more selected from the group consisting of spherical titanium oxide particles and spherical zinc oxide particles. More preferably, the external preparation for skin of ⁇ 9>, which is spherical titanium oxide particles.
  • the average particle size of the particles used as the component (d) is preferably 0.1 ⁇ m or more and 10 ⁇ m or less, more preferably 0.2 ⁇ m or more and 5 ⁇ m or less, and further preferably 0.5 ⁇ m or more and 2 ⁇ m or less, ⁇ 9> or ⁇ . 10> External skin preparation.
  • the content of the component (d) is preferably 1% by mass or more and 20% by mass or less, more preferably 1% by mass or more and 15% by mass or less, still more preferably 1% by mass or more and 10% by mass or less, still more preferably 1.
  • the external preparation for skin according to any one of ⁇ 9> to ⁇ 11>, which is 5% by mass or more and 10% by mass or less, more preferably 2% by mass or more and 10% by mass or less.
  • the mass ratio of the total amount of the components (a) to (c) to the component (d) [ ⁇ (a) + (b) + (c) ⁇ / (d)] is preferably 0.1 or more and 5 or less. , More preferably 0.2 or more and 3 or less, still more preferably 0.5 or more and 2 or less, still more preferably 0.5 or more and 1.5 or less, for external use of any one of ⁇ 9> to ⁇ 12>. Agent.
  • ⁇ 14> The external preparation for skin according to any one of ⁇ 1> to ⁇ 13>, which further contains an ultraviolet absorber as a component (e).
  • Ingredient (e) is preferably an oil-soluble organic ultraviolet absorber, more preferably 2-ethylhexyl paramethoxysilicate, 4-tert-butyl-4'-methoxydibenzoylmethane, octocrylene, dimethoxybenzylene dioxoimidazo.
  • the skin external preparation of ⁇ 14> which is one or more selected from the group consisting of hexyl diethylaminohydroxybenzoylbenzoate, and bisethylhexyloxyphenol methoxyphenyltriazine.
  • the content of the component (e) is preferably 0.2% by mass or more and 30% by mass or less, more preferably 1% by mass or more and 25% by mass or less, still more preferably 3% by mass or more and 20% by mass or less, still more preferably.
  • ⁇ 14> or ⁇ 15> external preparation for skin which is 5% by mass or more and 15% by mass or less.
  • the mass ratio of the total amount of the components (a) to (c) to the component (e) [ ⁇ (a) + (b) + (c) ⁇ / (e)] is preferably 0.1 or more and 5 or less. , More preferably 0.1 or more and 3 or less, still more preferably 0.2 or more and 1 or less, still more preferably 0.3 or more and 1 or less, still more preferably 0.3 or more and 0.5 or less, ⁇ 14>.
  • ⁇ 18> The external preparation for skin according to any one of ⁇ 1> to ⁇ 17>, which further contains an oil agent as a component (f) and preferably contains a non-volatile oil (f1).
  • the component (f1) is selected from one or more selected from the group consisting of ester oils, silicone oils, hydrocarbon oils, higher fatty acids, and higher alcohols, and more preferably selected from the group consisting of ester oils, silicone oils, and hydrocarbon oils.
  • external skin preparation which is one or more.
  • the content of the component (f1) is preferably 1% by mass or more and 99% by mass or less, more preferably 4% by mass or more and 90% by mass or less, still more preferably 8% by mass or more and 80% by mass or less, still more preferably 8% by mass. % Or more and 50% by mass or less, more preferably 8% by mass or more and 30% by mass or less, ⁇ 18> or ⁇ 19> for external use on the skin.
  • the mass ratio of the total amount of the components (a) to (c) to the component (f1) [ ⁇ (a) + (b) + (c) ⁇ / (f1)] is preferably 0.01 or more and 10 or less.
  • the mass ratio [(e) / (f1)] is preferably 0.01 or more and 10 or less, more preferably 0.02 or more and 5 or less, still more preferably 0.05 or more and 3 or less, still more preferably 0.1 or more.
  • the content of the component (f2) is preferably 1% by mass or more and 85% by mass or less, more preferably 5% by mass or more and 80% by mass or less, and further preferably 10% by mass or more and 75% by mass or less, ⁇ 23>.
  • External preparation for skin is preferably 1% by mass or more and 85% by mass or less, more preferably 5% by mass or more and 80% by mass or less, and further preferably 10% by mass or more and 75% by mass or less.
  • An external preparation for skin the following components (a) to (c): (A) Plate-shaped titanium oxide with a thickness of 100 nm or more and 120 nm or less, (B) Plate-shaped titanium oxide with a thickness of 125 nm or more and 145 nm or less, and (c) Plate-shaped titanium oxide with a thickness of 180 nm or more and 200 nm or less. It is made by blending The average particle size of the components (a) to (c) is 3 ⁇ m or more and 10 ⁇ m or less.
  • the blending amount of the component (a) is 5% by mass or more and 70% by mass or less, and the blending amount of the component (b) is 15% by mass or more and 75% by mass with respect to the total blending amount of the components (a) to (c) of 100% by mass. % Or less, and the blending amount of the component (c) is 5% by mass or more and 70% by mass or less.
  • An external preparation for skin wherein the total amount of the components (a) to (c) in the external preparation for skin is 2% by mass or more and 10% by mass or less.
  • An external preparation for skin the following components (a) to (c): (A) Plate-shaped titanium oxide with a thickness of 100 nm or more and 120 nm or less, (B) Plate-shaped titanium oxide with a thickness of 125 nm or more and 145 nm or less, and (c) Plate-shaped titanium oxide with a thickness of 180 nm or more and 200 nm or less. It is made by blending The average particle size of the components (a) to (c) is 3 ⁇ m or more and 10 ⁇ m or less.
  • the compounding ratio of the component (a), the component (b) and the component (c) with respect to 100% by mass of the total compounding amount of the components (a) to (c) satisfies the following condition 1.
  • An external preparation for skin wherein the total amount of the components (a) to (c) in the external preparation for skin is 2% by mass or more and 10% by mass or less.
  • Condition 1 In a three-phase diagram showing the mass% of the component (a), the component (b) and the component (c) with respect to 100% by mass of the total blending amount of the components (a) to (c), the blending ratio of each component is , It is within the range of the composition region surrounded by the 6 composition points shown below.
  • (A, b, c) (70,15,15), (28,26,46), (5,40,55), (5,67,28), (20,68,12), (57 , 33, 10) ⁇ 27>
  • An external preparation for skin the following components (a) to (c): (A) Plate-shaped titanium oxide with a thickness of 100 nm or more and 120 nm or less, (B) Plate-shaped titanium oxide with a thickness of 125 nm or more and 145 nm or less, and (c) Plate-shaped titanium oxide with a thickness of 180 nm or more and 200 nm or less. It is made by blending The average particle size of the components (a) to (c) is 3 ⁇ m or more and 10 ⁇ m or less.
  • the compounding ratio of the component (a), the component (b) and the component (c) with respect to 100% by mass of the total compounding amount of the components (a) to (c) satisfies the following condition 2.
  • An external preparation for skin wherein the total amount of the components (a) to (c) in the external preparation for skin is 2% by mass or more and 10% by mass or less.
  • Condition 2 In a three-phase diagram showing the mass% of the component (a), the component (b) and the component (c) with respect to 100% by mass of the total blending amount of the components (a) to (c), the blending ratio of each component is , It is within the range of the composition region surrounded by the 6 composition points shown below.
  • (A, b, c) (50,28,22), (25,45,30), (25,32,43), (15,43,42), (23,55,22), (42) , 43, 15) ⁇ 28>
  • one or more kinds of feel improvers selected from the group consisting of spherical titanium oxide particles and spherical zinc oxide particles are contained in an amount of 2% by mass or more and 10% by mass or less. It contains 5% by mass or more and 15% by mass or less of an oil-soluble organic ultraviolet absorber as the component (e).
  • ⁇ 29> The external preparation for skin according to any one of ⁇ 1> to ⁇ 28>, wherein the dosage form is liquid, gel-like, or cream-like.
  • ⁇ 31> A method for protecting the skin from infrared rays by applying the external preparation for skin according to any one of ⁇ 1> to ⁇ 30> to the skin.
  • ⁇ 32> The method of ⁇ 31>, wherein the infrared protection rate at a wavelength of 1500 nm is preferably 10% or more, more preferably 12% or more, still more preferably 15% or more.
  • the thickness of the plate-shaped titanium oxide used as the components (a) to (c) is accelerated by accelerating the components (a) to (c) using a scanning electron microscope (“VE-9800” manufactured by KEYENCE CORPORATION). It was obtained by observing under the conditions of voltage: 10 keV and observation magnification: 10,000 times, measuring the thickness of 50 particles in the observed image, and calculating the average value per number.
  • VE-9800 scanning electron microscope
  • the average particle size of the plate-shaped titanium oxide used as the components (a) to (c) and the spherical titanium oxide used as the component (d) is determined by a laser diffraction / scattering type particle size distribution measuring device (Horiba Seisakusho Co., Ltd.). Using LA920 ”), the average particle size was defined as the value of the median diameter (D50) measured with an aqueous dispersion having a relative refractive index of 2.0 and a particle size reference volume.
  • the aspect ratio of the plate-shaped titanium oxide used as the components (a) to (c) was calculated by (average particle size / thickness).
  • the value obtained by dividing the transmittance of the measurement sample by the transmittance of the control sample was defined as the transmittance X (%), and 100-X (%) was defined as the infrared protection rate. The larger this value is, the higher the infrared protection effect is.
  • Production Example 2 (Production of plate-shaped titanium oxide 2) As the untreated plate-shaped titanium oxide, "Featheleve PT-7801K” (thickness 134 nm, aspect ratio 95, average particle size 12.8 ⁇ m) manufactured by CQV was used instead of "Feathereve PT-7401K” manufactured by CQV. Except for this, the same treatment as in Production Example 1 was carried out to obtain plate-shaped titanium oxide 2 having a thickness of 134 nm, an aspect ratio of 64, and an average particle size of 8.6 ⁇ m.
  • Production Example 3 (Production of plate-shaped titanium oxide 3)
  • "Featheleve PT-7901K” thickness 191 nm, aspect ratio 58, average particle size 11.1 ⁇ m) manufactured by CQV was used instead of "Featheleve PT-7401K” manufactured by CQV. Except for this, the same treatment as in Production Example 1 was carried out to obtain plate-shaped titanium oxide 3 having a thickness of 191 nm, an aspect ratio of 44, and an average particle size of 8.5 ⁇ m.
  • Examples 1 to 12 and Comparative Examples 1 to 8 manufactured and evaluation of external preparations for skin
  • the ingredients shown in Table 1 were blended and mixed uniformly using a homogenizer to prepare a skin external preparation having the composition shown in Table 1.
  • the obtained external preparation for skin was evaluated by the above method.
  • the results are shown in Table 1.
  • the blending amount shown in Table 1 is the amount of the active ingredient (mass%) of each component.
  • the external preparations for skin of Examples 1 to 12 can have both an infrared ray protective effect and a natural color when applied to the skin.
  • Examples 1, 3, 4, 6, 8 and 9 in which the blending ratios of the components (a) to (c) satisfy the above condition 1 are more preferable because the overall evaluation is A or more, and the implementation satisfying the above condition 2.
  • Examples 4 and 6 have a comprehensive evaluation of A +, which is more preferable.
  • the external preparations for skin of Comparative Examples 1 to 8 did not have a sufficient effect in at least one of the infrared protective effect and the natural color when applied to the skin.
  • a +, A, B, C, D and D- shown in the three-phase diagram of FIG. 1 indicates the components (a) to (c) corresponding to the external preparations for skin of Examples 1 to 12 and Comparative Examples 1 to 8. ), The comprehensive evaluation is shown.
  • the external preparation for skin of the present invention has an excellent infrared protective effect, and when applied to the skin, redness and blueness are less likely to be recognized, and a natural color that blends in with the skin color can be obtained.
  • skin makeup It is useful as a fee.
  • the blending amount of the component (a) is 5% by mass or more and 70% by mass or less, and the blending amount of the component (b) is 15% by mass or more and 75% by mass or less with respect to the total blending amount of 100% by mass of the components (a) to (c).
  • Composition region 2 in which the blending amount of the component (c) is 5% by mass or more and 70% by mass or less Composition region satisfying condition 1

Abstract

La présente invention concerne une préparation externe pour la peau obtenue en combinant les composants suivants (a) à (c) : (a) un oxyde métallique de type plaque ayant une épaisseur de 100 à 120 nm, (b) un oxyde métallique de type plaque ayant une épaisseur de 125 à 145 nm, et (c) un oxyde métallique de type plaque ayant une épaisseur de 180 à 200 nm. Sur un total de 100 % en masse des quantités ajoutées de composants (a) par (c), la teneur en composant (a) est de 5 à 70 % en masse, la teneur en composant (b) est de 15 à 75 % en masse, et la teneur en composant (c) est de 5 à 70 % en masse.
PCT/JP2020/042695 2019-11-20 2020-11-17 Préparation externe pour la peau WO2021100676A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202080079384.4A CN114727920A (zh) 2019-11-20 2020-11-17 皮肤外用剂
KR1020227015676A KR20220080162A (ko) 2019-11-20 2020-11-17 피부 외용제

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019-209728 2019-11-20
JP2019209728 2019-11-20

Publications (1)

Publication Number Publication Date
WO2021100676A1 true WO2021100676A1 (fr) 2021-05-27

Family

ID=75964161

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2020/042695 WO2021100676A1 (fr) 2019-11-20 2020-11-17 Préparation externe pour la peau

Country Status (5)

Country Link
JP (1) JP2021080251A (fr)
KR (1) KR20220080162A (fr)
CN (1) CN114727920A (fr)
TW (1) TW202128123A (fr)
WO (1) WO2021100676A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016204267A (ja) * 2015-04-15 2016-12-08 花王株式会社 粉末化粧料
JP2017095361A (ja) * 2015-11-18 2017-06-01 花王株式会社 近赤外線防御化粧料組成物
JP2017122075A (ja) * 2016-01-08 2017-07-13 花王株式会社 水中油型皮膚化粧料
JP2017155006A (ja) * 2016-03-02 2017-09-07 株式会社コスモビューティー 複合粒子、化粧料組成物、及び、複合粒子の製造方法
JP2017171655A (ja) * 2016-03-17 2017-09-28 大塚製薬株式会社 近赤外線遮蔽用皮膚外用組成物
JP2019006712A (ja) * 2017-06-26 2019-01-17 御木本製薬株式会社 油中水型乳化組成物
JP2019131499A (ja) * 2018-01-30 2019-08-08 株式会社コーセー 皮膚外用剤又は化粧料

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3874412B2 (ja) * 2002-09-30 2007-01-31 株式会社資生堂 皮膚外用剤
JP4874577B2 (ja) * 2005-06-10 2012-02-15 株式会社クラレ 皮膚外用剤
CA2695307A1 (fr) * 2007-07-30 2009-02-05 Yohei Tanaka Agent de protection contre une lesion de tissu biologique provoquee par un rayonnement dans le proche infrarouge, et produit comprenant l'agent
JP5839984B2 (ja) * 2011-12-23 2016-01-06 日揮触媒化成株式会社 金属酸化物粒子の製造方法
JP6003287B2 (ja) * 2012-06-26 2016-10-05 日油株式会社 Ｏ／ｗ型の紫外線防止用皮膚化粧料
JP5878447B2 (ja) * 2012-09-12 2016-03-08 富士フイルム株式会社 ベースメイク化粧料
JP2015086157A (ja) * 2013-10-30 2015-05-07 ポーラ化成工業株式会社 皮膚外用剤
JP6580907B2 (ja) * 2014-11-20 2019-09-25 花王株式会社 皮膚化粧料
JP2016204368A (ja) * 2015-04-14 2016-12-08 株式会社Ａｐｐｌａｕｓｅ 酸化セリウム微粒子を含有する組成物
JP2017036221A (ja) * 2015-08-06 2017-02-16 三菱瓦斯化学株式会社 化粧料用粒子及びその製造法、並びに該粒子を用いた化粧料組成物
JP2017141179A (ja) * 2016-02-09 2017-08-17 株式会社クレハ 皮膚外用剤

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016204267A (ja) * 2015-04-15 2016-12-08 花王株式会社 粉末化粧料
JP2017095361A (ja) * 2015-11-18 2017-06-01 花王株式会社 近赤外線防御化粧料組成物
JP2017122075A (ja) * 2016-01-08 2017-07-13 花王株式会社 水中油型皮膚化粧料
JP2017155006A (ja) * 2016-03-02 2017-09-07 株式会社コスモビューティー 複合粒子、化粧料組成物、及び、複合粒子の製造方法
JP2017171655A (ja) * 2016-03-17 2017-09-28 大塚製薬株式会社 近赤外線遮蔽用皮膚外用組成物
JP2019006712A (ja) * 2017-06-26 2019-01-17 御木本製薬株式会社 油中水型乳化組成物
JP2019131499A (ja) * 2018-01-30 2019-08-08 株式会社コーセー 皮膚外用剤又は化粧料

Also Published As

Publication number Publication date
KR20220080162A (ko) 2022-06-14
JP2021080251A (ja) 2021-05-27
TW202128123A (zh) 2021-08-01
CN114727920A (zh) 2022-07-08

Similar Documents

Publication Publication Date Title
KR101563853B1 (ko) 자외선 차단제 화장료
KR101860977B1 (ko) 수중유형 유화 화장료
JP4560122B2 (ja) 酸化チタン分散体およびそれを配合した化粧料
JP2017122075A (ja) 水中油型皮膚化粧料
JP7295797B2 (ja) 油中水型乳化化粧料
JP2017095361A (ja) 近赤外線防御化粧料組成物
JP2017137300A (ja) 水中油型乳化化粧料
WO2021100676A1 (fr) Préparation externe pour la peau
JP6865522B2 (ja) 水中油型紫外線防御化粧料
JP2019043920A (ja) 油中水型乳化化粧料
WO2022239842A1 (fr) Agent à usage externe pour la peau
CN113195060B (zh) 外用剂
TWI828835B (zh) 皮膚外用劑
JP2020105175A (ja) 皮膚外用剤
JP2020105177A (ja) 皮膚外用剤
JP2020105176A (ja) 皮膚外用剤
JP2020128344A (ja) 水中油型乳化化粧料
WO2021193854A1 (fr) Produit cosmétique émulsifié de type huile dans l'eau
JP2022051592A (ja) 油中水型乳化化粧料

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20889053

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 20227015676

Country of ref document: KR

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20889053

Country of ref document: EP

Kind code of ref document: A1